SMCP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Sperm mitochondria differ in morphology and subcellular localization from those of somatic cells. They are elongated, flattened, and arranged circumferentially to form a helical coiled sheath in the midpiece of the sperm flagellum. The protein encoded by this gene localizes to the capsule associated with the mitochondrial outer membranes and is thought to function in the organization and stabilization of the helical structure of the sperm's mitochondrial sheath. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1reproduction (GO:0000003)9.54805640
2spermatid development (GO:0007286)9.51193226
3regulation of cilium movement (GO:0003352)9.43903586
4cilium movement (GO:0003341)9.10058767
5motile cilium assembly (GO:0044458)8.79069722
6sperm capacitation (GO:0048240)8.40803396
7epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.93735874
8single fertilization (GO:0007338)7.77700093
9response to pheromone (GO:0019236)7.55990828
10rRNA methylation (GO:0031167)7.34378307
11protein targeting to Golgi (GO:0000042)7.29302645
12phosphatidylethanolamine biosynthetic process (GO:0006646)7.25811191
13male meiosis (GO:0007140)7.14252009
14piRNA metabolic process (GO:0034587)7.02120420
15establishment of protein localization to Golgi (GO:0072600)6.99055595
16retrograde transport, vesicle recycling within Golgi (GO:0000301)6.81982404
17phosphatidylethanolamine metabolic process (GO:0046337)6.70148637
18synaptonemal complex organization (GO:0070193)6.67986830
19organic cation transport (GO:0015695)6.48625024
20fertilization (GO:0009566)6.43841904
21synaptonemal complex assembly (GO:0007130)6.42605116
22negative regulation of inclusion body assembly (GO:0090084)6.42126547
23rRNA modification (GO:0000154)6.18889016
24spermatogenesis (GO:0007283)6.07911808
25ventricular system development (GO:0021591)6.06447404
26male gamete generation (GO:0048232)6.05679973
27microtubule depolymerization (GO:0007019)6.04677605
28centriole replication (GO:0007099)5.84702486
29regulation of microtubule-based movement (GO:0060632)5.84281040
30gamete generation (GO:0007276)5.56323629
31regulation of inclusion body assembly (GO:0090083)5.42145992
32cellular process involved in reproduction in multicellular organism (GO:0022412)5.34806021
33RNA destabilization (GO:0050779)5.27797864
34germ cell development (GO:0007281)5.26798897
35centriole assembly (GO:0098534)5.20706214
36protein localization to Golgi apparatus (GO:0034067)5.20167690
37calcium ion-dependent exocytosis (GO:0017156)5.16193078
38cellular ketone body metabolic process (GO:0046950)5.08710505
39cell recognition (GO:0008037)4.97474659
40regulation of Rab GTPase activity (GO:0032313)4.95356513
41positive regulation of Rab GTPase activity (GO:0032851)4.95356513
42male meiosis I (GO:0007141)4.93191286
43regulation of transcription involved in cell fate commitment (GO:0060850)4.71539410
44left/right pattern formation (GO:0060972)4.69225110
45microtubule severing (GO:0051013)4.52198841
46ketone body metabolic process (GO:1902224)4.48536449
47glycerol ether metabolic process (GO:0006662)4.38087247
48* multicellular organismal reproductive process (GO:0048609)4.36232110
49chromosome organization involved in meiosis (GO:0070192)4.32770747
50antigen processing and presentation via MHC class Ib (GO:0002475)4.30873123
51chromatin silencing (GO:0006342)4.28551730
52DNA methylation involved in gamete generation (GO:0043046)4.21013513
53genitalia morphogenesis (GO:0035112)4.16389062
54multicellular organismal movement (GO:0050879)4.10392358
55musculoskeletal movement (GO:0050881)4.10392358
56meiotic nuclear division (GO:0007126)4.09921571
57seminiferous tubule development (GO:0072520)4.08026188
58ether metabolic process (GO:0018904)4.04073024
59spermatid nucleus differentiation (GO:0007289)3.96503522
60meiosis I (GO:0007127)3.91225678
61monoubiquitinated protein deubiquitination (GO:0035520)3.89574479
62protein polyglutamylation (GO:0018095)3.78122709
63regulation of somitogenesis (GO:0014807)3.66303826
64response to acidic pH (GO:0010447)3.63058557
65chaperone-mediated protein complex assembly (GO:0051131)3.60348363
66membrane protein intracellular domain proteolysis (GO:0031293)3.57461880
67microtubule nucleation (GO:0007020)3.57192773
68multicellular organismal development (GO:0007275)3.53052821
69protein-DNA complex disassembly (GO:0032986)3.49398039
70nucleosome disassembly (GO:0006337)3.49398039
71protein localization to cilium (GO:0061512)3.49136898
72negative regulation of Rho protein signal transduction (GO:0035024)3.41588663
73cellular response to pH (GO:0071467)3.40682140
74glycolytic process (GO:0006096)3.40637450
75homeostasis of number of cells within a tissue (GO:0048873)3.39305750
76cerebral cortex neuron differentiation (GO:0021895)3.38392429
77regulation of acrosome reaction (GO:0060046)3.36476125
78regulation of interleukin-13 production (GO:0032656)3.35490303
79peptidyl-threonine dephosphorylation (GO:0035970)3.34974169
80protein refolding (GO:0042026)3.34951054
81chromosome condensation (GO:0030261)3.31055280
82DNA packaging (GO:0006323)3.25258787
83antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.23860471
84antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.23606884
85antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.23606884
86regulation of T-helper 2 cell differentiation (GO:0045628)3.20702362
87coenzyme catabolic process (GO:0009109)3.18126491
88microtubule-based movement (GO:0007018)3.16596882
89carnitine transport (GO:0015879)3.15317633
90amino-acid betaine transport (GO:0015838)3.15317633
91meiotic cell cycle (GO:0051321)3.14859951
92negative regulation of organelle assembly (GO:1902116)3.12932667
93glomerular visceral epithelial cell development (GO:0072015)3.12143491
94cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.12031654
95mitochondrial fission (GO:0000266)3.11675974
96microtubule polymerization or depolymerization (GO:0031109)3.10194154
97histone H3-K9 demethylation (GO:0033169)3.08203360
98polyol catabolic process (GO:0046174)3.03450208
99glomerular epithelial cell development (GO:0072310)3.03405054
100nuclear pore complex assembly (GO:0051292)3.02688835
101protein depolymerization (GO:0051261)3.02574672
102cilium organization (GO:0044782)3.00529610
103sexual reproduction (GO:0019953)2.99387676
104intraciliary transport (GO:0042073)2.99050591
105mitotic G1 DNA damage checkpoint (GO:0031571)2.98520759
106regulation of phosphoprotein phosphatase activity (GO:0043666)2.97769907
107DNA conformation change (GO:0071103)2.97700610
108alditol metabolic process (GO:0019400)2.96672366
109Golgi to endosome transport (GO:0006895)2.96567883
110protein K11-linked deubiquitination (GO:0035871)2.96429370
111carnitine transmembrane transport (GO:1902603)2.90547157
112cilium assembly (GO:0042384)2.89855396
113lactate metabolic process (GO:0006089)2.89241130
114negative regulation of gene expression, epigenetic (GO:0045814)2.88655078
115cranial nerve morphogenesis (GO:0021602)2.87629260
116nucleus organization (GO:0006997)2.84499208
117positive regulation of guanylate cyclase activity (GO:0031284)2.83570863
118peptidyl-glutamic acid modification (GO:0018200)2.81726433
119positive regulation of glycolytic process (GO:0045821)2.80689498
120centrosome duplication (GO:0051298)2.79971849
121nucleoside diphosphate phosphorylation (GO:0006165)2.79209524
122regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.78450335
123regulation of spindle checkpoint (GO:0090231)2.75673182
124single strand break repair (GO:0000012)2.73951862
125cellular component assembly involved in morphogenesis (GO:0010927)2.72859098
126gene silencing by RNA (GO:0031047)2.72369380
127regulation of protein kinase A signaling (GO:0010738)2.72346743
128polyamine biosynthetic process (GO:0006596)2.65865253
129cilium morphogenesis (GO:0060271)2.64405098
130antigen processing and presentation of endogenous antigen (GO:0019883)2.64129653
131regulation of protein kinase C signaling (GO:0090036)2.63100831
132regulation of centriole replication (GO:0046599)2.63025300
133axoneme assembly (GO:0035082)2.62250736
134negative regulation of skeletal muscle tissue development (GO:0048642)2.62083698
135RNA localization (GO:0006403)2.59282687
136fusion of sperm to egg plasma membrane (GO:0007342)15.6732406
137* sperm motility (GO:0030317)13.5538715
138cilium or flagellum-dependent cell motility (GO:0001539)12.3097348
139plasma membrane fusion (GO:0045026)11.9564725
140sperm-egg recognition (GO:0035036)11.4944572
141multicellular organism reproduction (GO:0032504)11.4206791
142acrosome reaction (GO:0007340)11.1946217
143cell wall macromolecule metabolic process (GO:0044036)10.9155716
144cell wall macromolecule catabolic process (GO:0016998)10.9155716
145epithelial cilium movement (GO:0003351)10.8183000
146acrosome assembly (GO:0001675)10.4101637
147binding of sperm to zona pellucida (GO:0007339)10.3855841
148cell-cell recognition (GO:0009988)10.2931075
149axonemal dynein complex assembly (GO:0070286)10.2594738

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.76019002
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.72999397
3EZH2_22144423_ChIP-Seq_EOC_Human4.51879243
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.49903603
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.09840665
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.62495466
7MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.48881843
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.86122783
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.52729454
10VDR_22108803_ChIP-Seq_LS180_Human2.51134767
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.44850576
12STAT6_21828071_ChIP-Seq_BEAS2B_Human2.43137323
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.30359600
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.23023004
15VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.22653398
16CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.10159964
17ELF1_20517297_ChIP-Seq_JURKAT_Human2.09209213
18CTBP1_25329375_ChIP-Seq_LNCAP_Human2.05216503
19EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.02124963
20DROSHA_22980978_ChIP-Seq_HELA_Human2.00236206
21ZNF274_21170338_ChIP-Seq_K562_Hela1.99260044
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.92535879
23RAC3_21632823_ChIP-Seq_H3396_Human1.85614546
24EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.83975497
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.83426533
26CTCF_27219007_Chip-Seq_Bcells_Human1.83150141
27ERA_21632823_ChIP-Seq_H3396_Human1.83087779
28RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.83017381
29TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.75662960
30STAT1_17558387_ChIP-Seq_HELA_Human1.74315251
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.71704835
32WDR5_24793694_ChIP-Seq_LNCAP_Human1.70919340
33CBP_20019798_ChIP-Seq_JUKART_Human1.68167491
34IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.68167491
35ELK4_26923725_Chip-Seq_MESODERM_Mouse1.67978974
36* NANOG_20526341_ChIP-Seq_ESCs_Human1.67796874
37KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.65296547
38SMC4_20622854_ChIP-Seq_HELA_Human1.64688528
39FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63144416
40YY1_22570637_ChIP-Seq_MALME-3M_Human1.61954360
41MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.61416099
42GATA1_26923725_Chip-Seq_HPCs_Mouse1.61114851
43BCOR_27268052_Chip-Seq_Bcells_Human1.58310744
44TDRD3_21172665_ChIP-Seq_MCF-7_Human1.58038640
45* BCL6_27268052_Chip-Seq_Bcells_Human1.57702852
46* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.56651476
47GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.56115558
48TAF15_26573619_Chip-Seq_HEK293_Human1.54654318
49UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.53066706
50PHF8_20622854_ChIP-Seq_HELA_Human1.52452360
51* TAF2_19829295_ChIP-Seq_ESCs_Human1.51875522
52KDM2B_26808549_Chip-Seq_REH_Human1.51764182
53MYC_19829295_ChIP-Seq_ESCs_Human1.49936964
54PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.49392241
55ARNT_22903824_ChIP-Seq_MCF-7_Human1.49111420
56LXR_22292898_ChIP-Seq_THP-1_Human1.45383896
57ER_23166858_ChIP-Seq_MCF-7_Human1.45023973
58TAL1_26923725_Chip-Seq_HPCs_Mouse1.44003263
59AUTS2_25519132_ChIP-Seq_293T-REX_Human1.43407143
60CBX2_27304074_Chip-Seq_ESCs_Mouse1.43256310
61* P68_20966046_ChIP-Seq_HELA_Human1.43186670
62CTBP2_25329375_ChIP-Seq_LNCAP_Human1.41172152
63* TP63_22573176_ChIP-Seq_HFKS_Human1.40973108
64AR_25329375_ChIP-Seq_VCAP_Human1.40817842
65KAP1_22055183_ChIP-Seq_ESCs_Mouse1.40692539
66* E2F1_20622854_ChIP-Seq_HELA_Human1.39984097
67CBX2_22325352_ChIP-Seq_293T-Rex_Human1.37650944
68P300_27268052_Chip-Seq_Bcells_Human1.36654591
69SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.36303148
70* CTCF_20526341_ChIP-Seq_ESCs_Human1.35737395
71* SOX2_22085726_ChIP-Seq_NPCs_Mouse1.35037271
72* OCT4_20526341_ChIP-Seq_ESCs_Human1.34472101
73PCGF2_27294783_Chip-Seq_NPCs_Mouse1.34464913
74NFE2_27457419_Chip-Seq_LIVER_Mouse1.32846610
75ETV1_20927104_ChIP-Seq_GIST48_Human1.31585238
76ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.31166113
77P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.30291767
78PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.30060455
79* RBPJ_21746931_ChIP-Seq_IB4_Human1.29601111
80GATA3_21867929_ChIP-Seq_CD8_Mouse1.29425636
81TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.28195048
82TP53_18474530_ChIP-ChIP_U2OS_Human1.27741842
83KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.27717890
84FLI1_21867929_ChIP-Seq_TH2_Mouse1.27208978
85* HNFA_21074721_ChIP-Seq_CACO-2_Human1.27147203
86P53_21459846_ChIP-Seq_SAOS-2_Human1.27010269
87SUZ12_27294783_Chip-Seq_ESCs_Mouse1.26594203
88EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.25923843
89* CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.25694797
90SUZ12_27294783_Chip-Seq_NPCs_Mouse1.25044913
91REST_21632747_ChIP-Seq_MESCs_Mouse1.24941966
92GATA3_21867929_ChIP-Seq_TH1_Mouse1.24658100
93TP63_19390658_ChIP-ChIP_HaCaT_Human1.24649624
94ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.24547677
95LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.24522706
96SMAD3_21741376_ChIP-Seq_EPCs_Human1.23224285
97TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20900239
98DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.19998117
99FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.18061745
100SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.17823752
101* CEBPB_22108803_ChIP-Seq_LS180_Human1.16968560
102CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.15550604
103* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.14497368
104SMRT_27268052_Chip-Seq_Bcells_Human1.14042668
105EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.13946937
106P300_19829295_ChIP-Seq_ESCs_Human1.13507142
107SA1_27219007_Chip-Seq_Bcells_Human1.13484782
108POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.13451609
109TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13451609
110GATA3_21878914_ChIP-Seq_MCF-7_Human1.12093816
111ZFP57_27257070_Chip-Seq_ESCs_Mouse1.11417694
112RAD21_21589869_ChIP-Seq_MESCs_Mouse1.11316010
113PHF8_20622853_ChIP-Seq_HELA_Human1.11285044
114GF1_26923725_Chip-Seq_HPCs_Mouse1.11215496
115CRX_20693478_ChIP-Seq_RETINA_Mouse1.10986323
116* ETV2_25802403_ChIP-Seq_MESCs_Mouse1.10251860
117NANOG_18555785_Chip-Seq_ESCs_Mouse1.10010282
118PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.09170451
119CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08742814
120NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.08179591
121TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07763317
122EZH2_27294783_Chip-Seq_ESCs_Mouse1.07175719
123RUNX_20019798_ChIP-Seq_JUKART_Human1.06480824
124* PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.06271473
125SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.05360767
126SMAD4_21741376_ChIP-Seq_HESCs_Human1.05150401
127OCT4_18555785_Chip-Seq_ESCs_Mouse1.03546633
128SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.03537482
129NFYA_21822215_ChIP-Seq_K562_Human1.03368569
130FUS_26573619_Chip-Seq_HEK293_Human1.03241703
131RNF2_27304074_Chip-Seq_NSC_Mouse1.02642966
132KLF5_25053715_ChIP-Seq_YYC3_Human1.02615590
133RUNX1_26923725_Chip-Seq_HPCs_Mouse1.02574799
134TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01927963
135PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.00971815
136CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.00947637
137PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00626458
138* GATA6_21074721_ChIP-Seq_CACO-2_Human1.00441928
139CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.00408269
140SMAD4_21741376_ChIP-Seq_EPCs_Human1.00041625
141SMAD4_21799915_ChIP-Seq_A2780_Human0.99557464
142SPI1_26923725_Chip-Seq_HPCs_Mouse0.98350108
143RUNX2_22187159_ChIP-Seq_PCA_Human0.98349237
144P53_22387025_ChIP-Seq_ESCs_Mouse0.97646574
145KLF4_19829295_ChIP-Seq_ESCs_Human0.97575838
146SA1_27219007_Chip-Seq_ERYTHROID_Human0.97505084
147OCT4_21477851_ChIP-Seq_ESCs_Mouse0.96883106
148EZH2_27294783_Chip-Seq_NPCs_Mouse0.96746609
149MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96420757
150CMYC_18555785_Chip-Seq_ESCs_Mouse0.96291917
151MYC_27129775_Chip-Seq_CORNEA_Mouse0.95485582
152EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.94894209
153GATA1_19941827_ChIP-Seq_MEL86_Mouse0.94372640
154NFYB_21822215_ChIP-Seq_K562_Human0.94322451
155RXRA_24833708_ChIP-Seq_LIVER_Mouse0.94299994
156TCF4_23295773_ChIP-Seq_U87_Human0.93039186
157KLF4_18555785_Chip-Seq_ESCs_Mouse0.92775302
158TBL1_22424771_ChIP-Seq_293T_Human0.92508153
159P300_18555785_Chip-Seq_ESCs_Mouse0.92163425
160ESET_19884257_ChIP-Seq_ESCs_Mouse0.91769783
161RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.90405655
162SMAD3_21741376_ChIP-Seq_ESCs_Human0.90392815
163* OCT1_27270436_Chip-Seq_PROSTATE_Human0.90355980
164ESRRB_18555785_Chip-Seq_ESCs_Mouse0.90214329
165MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.89897738
166* ERG_20517297_ChIP-Seq_VCAP_Human0.89213287
167NFIB_24661679_ChIP-Seq_LUNG_Mouse0.88740354
168STAT3_18555785_ChIP-Seq_MESCs_Mouse0.88273581
169EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.87026603
170SOX11_22085726_ChIP-Seq_ESNs_Mouse0.86982588
171RARA_24833708_ChIP-Seq_LIVER_Mouse0.86254607

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0003698_abnormal_male_reproductive6.18082158
2MP0001929_abnormal_gametogenesis5.45428179
3MP0008877_abnormal_DNA_methylation4.05991758
4MP0002210_abnormal_sex_determination3.37454247
5* MP0002161_abnormal_fertility/fecundity3.35363257
6MP0002653_abnormal_ependyma_morphology3.34609025
7MP0001348_abnormal_lacrimal_gland3.25451527
8MP0001145_abnormal_male_reproductive2.89442238
9MP0005670_abnormal_white_adipose2.85299963
10MP0005623_abnormal_meninges_morphology2.58615978
11MP0000653_abnormal_sex_gland2.50075093
12MP0000678_abnormal_parathyroid_gland2.39988887
13MP0003718_maternal_effect2.25572207
14* MP0005410_abnormal_fertilization15.7187545
15MP0002282_abnormal_trachea_morphology1.97581038
16MP0002132_abnormal_respiratory_system1.74490841
17MP0001485_abnormal_pinna_reflex1.72941650
18MP0005423_abnormal_somatic_nervous1.72747769
19MP0005451_abnormal_body_composition1.68246257
20MP0002822_catalepsy1.65826004
21MP0005310_abnormal_salivary_gland1.61429944
22MP0005379_endocrine/exocrine_gland_phen1.54339383
23MP0002249_abnormal_larynx_morphology1.49587266
24MP0003878_abnormal_ear_physiology1.49398425
25MP0005377_hearing/vestibular/ear_phenot1.49398425
26MP0001765_abnormal_ion_homeostasis1.47623477
27MP0001486_abnormal_startle_reflex1.41360056
28MP0009053_abnormal_anal_canal1.33735516
29MP0008995_early_reproductive_senescence1.33724891
30MP0004859_abnormal_synaptic_plasticity1.32725843
31MP0002160_abnormal_reproductive_system1.31253468
32MP0009046_muscle_twitch1.23376127
33MP0003646_muscle_fatigue1.20581043
34MP0002138_abnormal_hepatobiliary_system1.12755278
35MP0004233_abnormal_muscle_weight1.12335982
36MP0001963_abnormal_hearing_physiology1.11275499
37MP0002735_abnormal_chemical_nociception1.08576037
38MP0005647_abnormal_sex_gland1.07058032
39MP0002127_abnormal_cardiovascular_syste1.04859544
40MP0005395_other_phenotype1.02843511
41MP0000026_abnormal_inner_ear0.94921142
42MP0000955_abnormal_spinal_cord0.93987180
43MP0005248_abnormal_Harderian_gland0.93459113
44MP0004510_myositis0.91977980
45MP0005636_abnormal_mineral_homeostasis0.91166612
46MP0000569_abnormal_digit_pigmentation0.91119605
47MP0008569_lethality_at_weaning0.89537183
48MP0003115_abnormal_respiratory_system0.80266525
49MP0002067_abnormal_sensory_capabilities0.77113302
50MP0000681_abnormal_thyroid_gland0.76248272
51MP0001905_abnormal_dopamine_level0.75134038
52MP0002557_abnormal_social/conspecific_i0.73577706
53MP0005666_abnormal_adipose_tissue0.72626592
54MP0005083_abnormal_biliary_tract0.69819587
55MP0001984_abnormal_olfaction0.69806915
56MP0008058_abnormal_DNA_repair0.69180239
57MP0000049_abnormal_middle_ear0.66106063
58MP0001324_abnormal_eye_pigmentation0.65522366
59MP0001879_abnormal_lymphatic_vessel0.64395693
60MP0005389_reproductive_system_phenotype0.63725975
61MP0001666_abnormal_nutrient_absorption0.63470899
62MP0003950_abnormal_plasma_membrane0.63023893
63MP0004085_abnormal_heartbeat0.62840384
64MP0003077_abnormal_cell_cycle0.62525133
65MP0001293_anophthalmia0.61496997
66MP0002928_abnormal_bile_duct0.60670015
67MP0004036_abnormal_muscle_relaxation0.60299343
68MP0009697_abnormal_copulation0.58953565
69MP0000003_abnormal_adipose_tissue0.57787128
70MP0002139_abnormal_hepatobiliary_system0.56613537
71MP0000516_abnormal_urinary_system0.55913932
72MP0005367_renal/urinary_system_phenotyp0.55913932
73MP0004484_altered_response_of0.55628162
74MP0000358_abnormal_cell_content/0.54188282
75MP0005167_abnormal_blood-brain_barrier0.53043396
76MP0000613_abnormal_salivary_gland0.52730073
77MP0002572_abnormal_emotion/affect_behav0.51560018
78MP0001764_abnormal_homeostasis0.51268954
79MP0003699_abnormal_female_reproductive0.51104562
80MP0004019_abnormal_vitamin_homeostasis0.50816832
81MP0002733_abnormal_thermal_nociception0.50662894
82MP0002272_abnormal_nervous_system0.50654732
83MP0003329_amyloid_beta_deposits0.49948825
84MP0003137_abnormal_impulse_conducting0.47065497
85MP0009745_abnormal_behavioral_response0.46909768
86MP0003879_abnormal_hair_cell0.46021341
87MP0004270_analgesia0.45998733
88MP0000249_abnormal_blood_vessel0.45971945
89MP0001270_distended_abdomen0.44595508
90MP0002971_abnormal_brown_adipose0.44344408
91MP0002734_abnormal_mechanical_nocicepti0.44313273
92MP0005535_abnormal_body_temperature0.43982997
93MP0009115_abnormal_fat_cell0.43023868
94MP0003011_delayed_dark_adaptation0.42344177
95MP0002295_abnormal_pulmonary_circulatio0.41276545
96MP0010094_abnormal_chromosome_stability0.38792363
97MP0002269_muscular_atrophy0.38736955
98MP0003045_fibrosis0.38145940
99MP0002736_abnormal_nociception_after0.38104683
100MP0003091_abnormal_cell_migration0.37720073
101MP0003786_premature_aging0.37339471
102MP0005551_abnormal_eye_electrophysiolog0.36739195
103MP0005408_hypopigmentation0.35577361
104MP0000534_abnormal_ureter_morphology0.34692806
105MP0002234_abnormal_pharynx_morphology0.34630729
106MP0005365_abnormal_bile_salt0.34406642
107MP0001970_abnormal_pain_threshold0.34365328
108MP0005375_adipose_tissue_phenotype0.34253950
109MP0000470_abnormal_stomach_morphology0.34139293
110MP0005391_vision/eye_phenotype0.34068708
111MP0003633_abnormal_nervous_system0.33838113
112MP0005397_hematopoietic_system_phenotyp0.33170204
113MP0001545_abnormal_hematopoietic_system0.33170204
114MP0005253_abnormal_eye_physiology0.33107957
115MP0005084_abnormal_gallbladder_morpholo0.32892086
116MP0000230_abnormal_systemic_arterial0.32756968
117MP0000604_amyloidosis0.31960063
118MP0001501_abnormal_sleep_pattern0.31844017
119MP0003936_abnormal_reproductive_system0.31666371
120MP0003635_abnormal_synaptic_transmissio0.31437093
121MP0004043_abnormal_pH_regulation0.31393087
122MP0009278_abnormal_bone_marrow0.31166073
123MP0008875_abnormal_xenobiotic_pharmacok0.30470156
124MP0000751_myopathy0.30302941
125MP0001119_abnormal_female_reproductive0.29678471
126MP0010329_abnormal_lipoprotein_level0.29646412
127MP0003252_abnormal_bile_duct0.28968914
128MP0003631_nervous_system_phenotype0.28955957
129MP0002092_abnormal_eye_morphology0.28509108
130MP0008961_abnormal_basal_metabolism0.26772018
131MP0009672_abnormal_birth_weight0.25741883
132MP0003942_abnormal_urinary_system0.25546109
133MP0005388_respiratory_system_phenotype0.25329337
134MP0002133_abnormal_respiratory_system0.25329337
135MP0002118_abnormal_lipid_homeostasis0.25210213
136MP0004742_abnormal_vestibular_system0.23642920
137MP0002796_impaired_skin_barrier0.23518852
138MP0005360_urolithiasis0.22410050
139MP0002693_abnormal_pancreas_physiology0.21254950
140MP0003948_abnormal_gas_homeostasis0.21237243
141MP0001968_abnormal_touch/_nociception0.20814878
142MP0001440_abnormal_grooming_behavior0.20264409
143MP0001727_abnormal_embryo_implantation0.20189210
144MP0005275_abnormal_skin_tensile0.19854153
145MP0005319_abnormal_enzyme/_coenzyme0.19779739
146MP0002152_abnormal_brain_morphology0.19637112
147MP0004811_abnormal_neuron_physiology0.19484400
148MP0002229_neurodegeneration0.19417218
149MP0002108_abnormal_muscle_morphology0.18922991
150MP0003861_abnormal_nervous_system0.18402460
151MP0004130_abnormal_muscle_cell0.18063430
152MP0003300_gastrointestinal_ulcer0.17905010
153MP0008007_abnormal_cellular_replicative0.17228315
154MP0001661_extended_life_span0.17098084
155MP0008057_abnormal_DNA_replication0.16492198
156MP0003632_abnormal_nervous_system0.14717540
157MP0004885_abnormal_endolymph0.13747402
158MP0003111_abnormal_nucleus_morphology0.13674009
159MP0000920_abnormal_myelination0.13344154

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)8.98241711
2Abnormal respiratory epithelium morphology (HP:0012253)8.80594539
3Abnormal respiratory motile cilium morphology (HP:0005938)8.80594539
4Severe visual impairment (HP:0001141)7.82139213
5Rhinitis (HP:0012384)7.34585655
6Abnormal ciliary motility (HP:0012262)7.29570355
7Infertility (HP:0000789)6.70754338
8Chronic bronchitis (HP:0004469)6.69864496
9Nasal polyposis (HP:0100582)6.34872887
10Chronic hepatic failure (HP:0100626)5.52432680
11Abnormality of the nasal mucosa (HP:0000433)5.23026279
12Male infertility (HP:0003251)4.93732032
13Bronchitis (HP:0012387)4.83437136
14Resting tremor (HP:0002322)4.74922908
15Bony spicule pigmentary retinopathy (HP:0007737)4.71090855
16Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.65953522
17Attenuation of retinal blood vessels (HP:0007843)4.63495177
18Bronchiectasis (HP:0002110)4.46512184
19Nephronophthisis (HP:0000090)4.35724125
20Abnormality of macular pigmentation (HP:0008002)4.25602327
21Hypoalphalipoproteinemia (HP:0003233)3.74866363
22Hypoplasia of the thymus (HP:0000778)3.69559625
23Aplasia/Hypoplasia of the earlobes (HP:0009906)3.66468923
24Abnormal spermatogenesis (HP:0008669)3.64006269
25Recurrent bronchitis (HP:0002837)3.59152229
26Progressive sensorineural hearing impairment (HP:0000408)3.55794184
27Abnormal rod and cone electroretinograms (HP:0008323)3.48574767
28Recurrent otitis media (HP:0000403)3.46561988
29Recurrent sinusitis (HP:0011108)3.45962049
30Abnormality of the renal medulla (HP:0100957)3.39869354
31Menstrual irregularities (HP:0000858)3.39019717
32Postural instability (HP:0002172)3.20762718
33Tubulointerstitial nephritis (HP:0001970)3.20066659
34Hypoplastic ischia (HP:0003175)3.13780323
35Renovascular hypertension (HP:0100817)3.13607781
36Amelogenesis imperfecta (HP:0000705)3.09786733
37Impulsivity (HP:0100710)3.02972869
38Enlarged epiphyses (HP:0010580)2.99979651
39Insulin-resistant diabetes mellitus (HP:0000831)2.92229937
40Abnormality of the ischium (HP:0003174)2.83252746
41Progressive cerebellar ataxia (HP:0002073)2.82753527
42Portal hypertension (HP:0001409)2.81248083
43Unilateral renal agenesis (HP:0000122)2.80464836
44Tubulointerstitial abnormality (HP:0001969)2.75416240
45Abnormality of potassium homeostasis (HP:0011042)2.75085764
46Congenital malformation of the right heart (HP:0011723)2.74023922
47Double outlet right ventricle (HP:0001719)2.74023922
48Abnormality of the aortic arch (HP:0012303)2.73497255
49Gonadotropin excess (HP:0000837)2.70091045
50Abnormality of dental color (HP:0011073)2.67646655
51Generalized aminoaciduria (HP:0002909)2.66402761
52Tubular atrophy (HP:0000092)2.66325516
53Abnormality of the costochondral junction (HP:0000919)2.58092601
54Dyschromatopsia (HP:0007641)2.57499752
55Abnormality of the hepatic vasculature (HP:0006707)2.57447742
56Abnormal gallbladder physiology (HP:0012438)2.51161177
57Cholecystitis (HP:0001082)2.51161177
58Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.43523183
59Increased purine levels (HP:0004368)2.36941550
60Hyperuricemia (HP:0002149)2.36941550
61Ventricular tachycardia (HP:0004756)2.30955433
62Molar tooth sign on MRI (HP:0002419)2.29590096
63Abnormality of midbrain morphology (HP:0002418)2.29590096
64Progressive hearing impairment (HP:0001730)2.28309476
65Abnormality of the parathyroid morphology (HP:0011766)2.26516934
66Decreased central vision (HP:0007663)2.25125128
67Tubulointerstitial fibrosis (HP:0005576)2.22895814
68Myokymia (HP:0002411)2.22648899
69Azoospermia (HP:0000027)2.22315631
70Spastic tetraparesis (HP:0001285)2.21164925
71Subcapsular cataract (HP:0000523)2.15552554
72Polyuria (HP:0000103)2.13467101
73Heterotopia (HP:0002282)2.11276776
74Abnormal biliary tract physiology (HP:0012439)2.09652225
75Bile duct proliferation (HP:0001408)2.09652225
76Osteomalacia (HP:0002749)2.08846264
77Choroideremia (HP:0001139)2.07064387
78Recurrent pneumonia (HP:0006532)2.05398139
79Widely patent fontanelles and sutures (HP:0004492)2.02383846
80Flattened epiphyses (HP:0003071)2.01973394
81Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.2530340
82Absent/shortened dynein arms (HP:0200106)13.0921846
83Dynein arm defect of respiratory motile cilia (HP:0012255)13.0921846
84Hyponatremia (HP:0002902)1.98890684
85Medial flaring of the eyebrow (HP:0010747)1.98511398
86Hypophosphatemic rickets (HP:0004912)1.98437656
87Bell-shaped thorax (HP:0001591)1.98044439
88Abnormality of the lower motor neuron (HP:0002366)1.92778655
89Epiphyseal dysplasia (HP:0002656)1.92761629
90Absent frontal sinuses (HP:0002688)1.92329447
91Short ribs (HP:0000773)1.92181850
92Postaxial foot polydactyly (HP:0001830)1.90893158
93Intellectual disability, moderate (HP:0002342)1.89788321
94Renal Fanconi syndrome (HP:0001994)1.87905095
95Tetany (HP:0001281)1.87569396
96Hypolipoproteinemia (HP:0010981)1.83577247
97Bradycardia (HP:0001662)1.81516623
98Abnormal ventriculo-arterial connection (HP:0011563)1.81027401
99Transposition of the great arteries (HP:0001669)1.81027401
100Abnormal connection of the cardiac segments (HP:0011545)1.81027401
101Stage 5 chronic kidney disease (HP:0003774)1.80103559
102Insulin resistance (HP:0000855)1.79944456
103Abnormality of the epiphysis of the femoral head (HP:0010574)1.78970328
104Abnormality of chloride homeostasis (HP:0011422)1.77962706
105Focal segmental glomerulosclerosis (HP:0000097)1.77689803
106Optic nerve hypoplasia (HP:0000609)1.77463265
107Fibular hypoplasia (HP:0003038)1.76499774
108Abnormality of dentin (HP:0010299)1.76200689
109Abnormality of permanent molar morphology (HP:0011071)1.75003284
110Abnormality of the dental root (HP:0006486)1.75003284
111Taurodontia (HP:0000679)1.75003284
112Recurrent corneal erosions (HP:0000495)1.74324647
113Aplasia/Hypoplasia of the sacrum (HP:0008517)1.74041246
114Congenital hepatic fibrosis (HP:0002612)1.73638890
115Hemorrhage of the eye (HP:0011885)1.72172359
116Abnormality of the renal cortex (HP:0011035)1.71836101
117J-shaped sella turcica (HP:0002680)1.68131609
118Neoplasm of the heart (HP:0100544)1.67652319
119Upper limb muscle weakness (HP:0003484)1.66477879
120Microglossia (HP:0000171)1.66334901
121Asymmetric septal hypertrophy (HP:0001670)1.64156161
122Abnormality of molar (HP:0011077)1.62771017
123Abnormality of molar morphology (HP:0011070)1.62771017
124Abnormal drinking behavior (HP:0030082)1.61732289
125Polydipsia (HP:0001959)1.61732289
126Abnormality of renal excretion (HP:0011036)1.60290628
127Cystic liver disease (HP:0006706)1.60023733
128Hemiparesis (HP:0001269)1.59607667
129Abnormality of the dental pulp (HP:0006479)1.57907208
130Hypoplasia of the capital femoral epiphysis (HP:0003090)1.54114603
131Deformed sella turcica (HP:0002681)1.52795142
132Renal dysplasia (HP:0000110)1.51263816
133Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.50879956
134Amyotrophic lateral sclerosis (HP:0007354)1.46124383
135Hypercholesterolemia (HP:0003124)1.45875927
136Neurofibrillary tangles (HP:0002185)1.44837258
137Oculomotor apraxia (HP:0000657)1.44687044
138Truncal obesity (HP:0001956)1.43986840
139Glucose intolerance (HP:0000833)1.40523345
140Broad distal phalanx of finger (HP:0009836)1.39885621
141Bundle branch block (HP:0011710)1.39181423
142Postaxial hand polydactyly (HP:0001162)1.38978032
143Cone-rod dystrophy (HP:0000548)1.38170618
144Vascular calcification (HP:0004934)1.36761119
145Short thorax (HP:0010306)1.35349129
146Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.33282229
147Facial cleft (HP:0002006)1.33119555
148Potter facies (HP:0002009)1.29873459
149Facial shape deformation (HP:0011334)1.29873459
150Cerebral inclusion bodies (HP:0100314)1.29307444
151Pancreatic fibrosis (HP:0100732)1.27780138
152Abnormal urine output (HP:0012590)1.27668816
153Aplasia/Hypoplasia of the tongue (HP:0010295)1.27044026
154Hyporeflexia of lower limbs (HP:0002600)1.26467785
155Pachygyria (HP:0001302)1.25474252
156Cardiovascular calcification (HP:0011915)1.25308054
157Decreased electroretinogram (ERG) amplitude (HP:0000654)1.25227802
158Nephropathy (HP:0000112)1.21859588
159Chronic sinusitis (HP:0011109)1.20486417
160Macular degeneration (HP:0000608)1.19848766
161Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.18903169
162Absent epiphyses (HP:0010577)1.18903169
163Hyperkalemia (HP:0002153)1.18136677
164Median cleft lip (HP:0000161)1.17664244

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK48.08393573
2PDK38.08393573
3TESK15.72154216
4PRKD35.43067976
5PDK25.23845648
6ICK4.17048699
7DDR24.12566791
8BRD43.36475855
9PLK23.17131114
10PNCK3.01166121
11MAP4K22.54182971
12WNK42.52685034
13PTK2B2.41028427
14STK392.21959147
15DYRK1B1.94748999
16MST1R1.81450647
17PIK3CG1.70683794
18STK381.42445121
19CDK71.19136171
20NEK21.18950112
21CAMK1G1.18478961
22WNK11.11526866
23TYRO31.07984103
24PDK11.03825063
25KSR20.97846880
26CAMK1D0.97629262
27SIK20.93726333
28MAP3K90.82334051
29MAPK150.82226487
30MAP3K110.80083453
31BRAF0.78167632
32MAP2K60.73777300
33LMTK20.73755023
34PRKG20.67953872
35LATS20.67917708
36RPS6KA20.65387224
37MAP2K20.64605834
38MAP3K20.63990166
39UHMK10.62922266
40DYRK30.62449019
41STK30.61479136
42PASK0.58411210
43PDPK10.55496196
44PAK20.55438375
45SGK2230.54478359
46SGK4940.54478359
47TESK20.54073051
48RIPK40.53645898
49TTK0.53281774
50ROCK10.52922483
51CCNB10.52624533
52EEF2K0.51761639
53MAP3K80.50054270
54PAK10.49068313
55NEK60.48190249
56PRKAA20.47090947
57LATS10.45363404
58CDK30.44403625
59CHEK20.42820430
60IRAK10.42612545
61CHEK10.42557511
62WEE10.42115204
63MTOR0.40934823
64MARK10.37513906
65BMPR1B0.36592022
66SGK10.34563417
67RPS6KC10.32640562
68RPS6KL10.32640562
69TIE10.31205942
70CAMK40.30971113
71CDK120.30494466
72ATM0.29749362
73RPS6KA60.29047237
74AKT30.28409763
75NTRK20.28358463
76NTRK30.27885076
77PRKCG0.27336182
78ATR0.27216779
79MET0.26566539
80MARK20.26379181
81BRSK10.26350026
82PINK10.26194173
83MAPK140.25748479
84ARAF0.25651024
85PAK40.25395676
86MAPK100.22517260
87JAK30.21725065
88STK38L0.21132378
89PRKAA10.20560960
90MAPKAPK50.20505241
91CSNK1D0.19926376
92MUSK0.19255174
93IRAK20.19178097
94CDC70.17942591
95CAMKK10.17686087
96RPS6KB10.17566889
97RIPK10.17250102
98MAPK110.17065517
99OXSR10.16809805
100MAP3K40.16616667
101PRKCQ0.15386367
102AKT10.15102265
103SGK20.14590593
104FRK0.14419839
105FER0.13902896
106EPHB10.13455054
107TNIK0.13365900
108MINK10.12757542
109PRKCZ0.12400494
110CDK60.12302229
111GSK3B0.11298973
112MAP3K100.11157997
113STK100.09409806
114PLK40.09241094
115BRSK20.09037800
116TTN0.07279843
117EGFR0.07221769
118PRKACA0.07037328
119ACVR1B0.06995224
120PDGFRB0.06982458
121SGK30.06964241
122MYLK0.06956538
123CDK150.06434520
124MAPK90.06056655
125PLK10.05899745
126CDK10.05603026
127MAP3K10.04518353
128CDK20.04239276
129PKN10.03950151
130CAMK10.03925844
131PRKCB0.03888003
132MAPK80.03698825
133CDK180.03569012
134BLK0.03431896
135INSRR0.03424951
136PRKDC0.03382055
137CDK11A0.03159733
138PRKACB0.03026321
139CSNK2A20.02767730
140PRKACG0.02596476
141MAPK10.02509074
142SRC0.02462919
143MAP2K70.02377186
144RPS6KA10.02323806
145WNK30.02197586
146PAK60.02155747
147PRKG10.01922467
148CAMK2A0.01701913
149CSNK2A10.01446834
150ZAP700.01407335
151CDK40.01322258
152RPS6KA30.00891976
153FGFR20.00114686
154PRKCA0.00057857

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000727.11051912
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.61155353
3Fatty acid biosynthesis_Homo sapiens_hsa000614.34671370
4Olfactory transduction_Homo sapiens_hsa047403.30166952
5Pyruvate metabolism_Homo sapiens_hsa006203.25457439
6Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.21074060
7Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.93634011
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.69243149
9Propanoate metabolism_Homo sapiens_hsa006402.55140978
10Vitamin B6 metabolism_Homo sapiens_hsa007502.50032335
11Carbohydrate digestion and absorption_Homo sapiens_hsa049732.37039053
12Linoleic acid metabolism_Homo sapiens_hsa005912.33314454
13Glucagon signaling pathway_Homo sapiens_hsa049222.33055543
14Butanoate metabolism_Homo sapiens_hsa006502.31210981
15Dorso-ventral axis formation_Homo sapiens_hsa043202.16684462
16Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.15880732
17PPAR signaling pathway_Homo sapiens_hsa033202.14893914
18Glycerolipid metabolism_Homo sapiens_hsa005612.07677695
19Fatty acid degradation_Homo sapiens_hsa000711.77234050
20Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.75924530
21Fatty acid metabolism_Homo sapiens_hsa012121.70299466
22Fructose and mannose metabolism_Homo sapiens_hsa000511.70205245
23Selenocompound metabolism_Homo sapiens_hsa004501.68536574
24Mineral absorption_Homo sapiens_hsa049781.67269295
25Pentose phosphate pathway_Homo sapiens_hsa000301.61553954
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.59290269
27Oocyte meiosis_Homo sapiens_hsa041141.56349675
28Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.55345129
29Carbon metabolism_Homo sapiens_hsa012001.52291101
30ABC transporters_Homo sapiens_hsa020101.48807899
31Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.47588024
32Glycerophospholipid metabolism_Homo sapiens_hsa005641.47553231
33Phenylalanine metabolism_Homo sapiens_hsa003601.43352655
34Glycosaminoglycan degradation_Homo sapiens_hsa005311.41193466
35Basal transcription factors_Homo sapiens_hsa030221.40395877
36Antigen processing and presentation_Homo sapiens_hsa046121.25372043
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.23621577
38Biosynthesis of amino acids_Homo sapiens_hsa012301.21908788
39Type I diabetes mellitus_Homo sapiens_hsa049401.16527465
40Amphetamine addiction_Homo sapiens_hsa050311.15283905
41Fat digestion and absorption_Homo sapiens_hsa049751.14119427
42Cardiac muscle contraction_Homo sapiens_hsa042601.08796108
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.08431656
44Renin secretion_Homo sapiens_hsa049241.08374166
45Phototransduction_Homo sapiens_hsa047441.05775158
46Huntingtons disease_Homo sapiens_hsa050161.02754402
47mRNA surveillance pathway_Homo sapiens_hsa030151.02742116
48Fanconi anemia pathway_Homo sapiens_hsa034601.02562773
49Arginine and proline metabolism_Homo sapiens_hsa003301.00709760
50Bile secretion_Homo sapiens_hsa049761.00519837
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.97672599
52Allograft rejection_Homo sapiens_hsa053300.97422798
53Thyroid hormone synthesis_Homo sapiens_hsa049180.96859838
54Autoimmune thyroid disease_Homo sapiens_hsa053200.96504193
55Ether lipid metabolism_Homo sapiens_hsa005650.94982959
56Morphine addiction_Homo sapiens_hsa050320.94243906
57Arginine biosynthesis_Homo sapiens_hsa002200.88324782
58Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.85935778
59Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.85775331
60Graft-versus-host disease_Homo sapiens_hsa053320.85058862
61Renin-angiotensin system_Homo sapiens_hsa046140.84661017
62Insulin secretion_Homo sapiens_hsa049110.83311050
63Adipocytokine signaling pathway_Homo sapiens_hsa049200.83075366
64RNA transport_Homo sapiens_hsa030130.82905556
65Estrogen signaling pathway_Homo sapiens_hsa049150.81004221
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.79455076
67Viral myocarditis_Homo sapiens_hsa054160.78032745
68Hedgehog signaling pathway_Homo sapiens_hsa043400.77076829
69Chemical carcinogenesis_Homo sapiens_hsa052040.75819344
70Protein digestion and absorption_Homo sapiens_hsa049740.74457918
71Purine metabolism_Homo sapiens_hsa002300.73917254
72Salivary secretion_Homo sapiens_hsa049700.71438718
73Primary bile acid biosynthesis_Homo sapiens_hsa001200.68870860
74Arachidonic acid metabolism_Homo sapiens_hsa005900.66896165
75Glutathione metabolism_Homo sapiens_hsa004800.66885023
76Influenza A_Homo sapiens_hsa051640.66067029
77Nicotine addiction_Homo sapiens_hsa050330.65095777
78Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.63900501
79Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.63679336
80Tyrosine metabolism_Homo sapiens_hsa003500.62111076
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.61009274
82Glutamatergic synapse_Homo sapiens_hsa047240.60243913
83Sulfur metabolism_Homo sapiens_hsa009200.59700847
84cGMP-PKG signaling pathway_Homo sapiens_hsa040220.59617006
85Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.58637354
86Central carbon metabolism in cancer_Homo sapiens_hsa052300.58552552
87Calcium signaling pathway_Homo sapiens_hsa040200.57225887
88Tight junction_Homo sapiens_hsa045300.56760208
89Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.56228278
90Gastric acid secretion_Homo sapiens_hsa049710.55956217
91Taste transduction_Homo sapiens_hsa047420.55722015
92Aldosterone synthesis and secretion_Homo sapiens_hsa049250.54481131
93Collecting duct acid secretion_Homo sapiens_hsa049660.53572066
94Long-term potentiation_Homo sapiens_hsa047200.53459919
95Legionellosis_Homo sapiens_hsa051340.53362303
96Nitrogen metabolism_Homo sapiens_hsa009100.52651683
97Complement and coagulation cascades_Homo sapiens_hsa046100.51589654
98Pancreatic secretion_Homo sapiens_hsa049720.50935643
99Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.49645841
100Maturity onset diabetes of the young_Homo sapiens_hsa049500.49547747
101Endocytosis_Homo sapiens_hsa041440.48321570
102MAPK signaling pathway_Homo sapiens_hsa040100.46676324
103Acute myeloid leukemia_Homo sapiens_hsa052210.46194255
104Phosphatidylinositol signaling system_Homo sapiens_hsa040700.43849499
105Serotonergic synapse_Homo sapiens_hsa047260.43382076
106Inositol phosphate metabolism_Homo sapiens_hsa005620.42419129
107AMPK signaling pathway_Homo sapiens_hsa041520.42001075
108Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41512328
109Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.40937030
110Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.39836702
111Cholinergic synapse_Homo sapiens_hsa047250.38997280
112Synaptic vesicle cycle_Homo sapiens_hsa047210.37523160
113Retinol metabolism_Homo sapiens_hsa008300.37000350
114cAMP signaling pathway_Homo sapiens_hsa040240.35946490
115Vascular smooth muscle contraction_Homo sapiens_hsa042700.35656996
116Circadian entrainment_Homo sapiens_hsa047130.35031113
117Vitamin digestion and absorption_Homo sapiens_hsa049770.34079780
118GABAergic synapse_Homo sapiens_hsa047270.33443825
119Metabolic pathways_Homo sapiens_hsa011000.30765117
120Type II diabetes mellitus_Homo sapiens_hsa049300.27453397
121Transcriptional misregulation in cancer_Homo sapiens_hsa052020.24962404
122Viral carcinogenesis_Homo sapiens_hsa052030.24022552
123Oxytocin signaling pathway_Homo sapiens_hsa049210.23803172
124Prolactin signaling pathway_Homo sapiens_hsa049170.22883753
125Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.22857551
126Lysine degradation_Homo sapiens_hsa003100.22455682
127Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.22034796
128Steroid hormone biosynthesis_Homo sapiens_hsa001400.21456227
129Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.20963177
130Jak-STAT signaling pathway_Homo sapiens_hsa046300.19994356
131ECM-receptor interaction_Homo sapiens_hsa045120.19913392
132Adherens junction_Homo sapiens_hsa045200.19686680
133AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.18858836
134Alcoholism_Homo sapiens_hsa050340.17203115
135Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.16286736
136Cocaine addiction_Homo sapiens_hsa050300.16200881
137Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.15026202
138Insulin resistance_Homo sapiens_hsa049310.13749721
139VEGF signaling pathway_Homo sapiens_hsa043700.11821182
140N-Glycan biosynthesis_Homo sapiens_hsa005100.10875426

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