SMDT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a core regulatory component of a calcium channel in the mitochondrial inner membrane. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1UV protection (GO:0009650)9.27686791
2myelin assembly (GO:0032288)8.72916579
3hematopoietic stem cell differentiation (GO:0060218)8.54674256
4spinal cord development (GO:0021510)7.91930116
5hair cell differentiation (GO:0035315)7.55967121
6organelle membrane fusion (GO:0090174)7.21018007
7nucleotide-excision repair, DNA damage removal (GO:0000718)6.90638779
8DNA excision (GO:0044349)6.90638779
9neuronal ion channel clustering (GO:0045161)6.76610991
10negative regulation of catenin import into nucleus (GO:0035414)6.51756413
11positive regulation of TOR signaling (GO:0032008)6.47912559
12lysosome localization (GO:0032418)6.22572790
13regulation of early endosome to late endosome transport (GO:2000641)6.16284603
14regulation of receptor recycling (GO:0001919)6.16059749
15negative regulation of organelle assembly (GO:1902116)5.99941763
16ATP synthesis coupled proton transport (GO:0015986)5.90241750
17energy coupled proton transport, down electrochemical gradient (GO:0015985)5.90241750
18mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.68513147
19regulation of cholesterol efflux (GO:0010874)5.64134036
20protein complex biogenesis (GO:0070271)5.30680947
217-methylguanosine mRNA capping (GO:0006370)5.18661512
22negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)5.07527075
237-methylguanosine RNA capping (GO:0009452)4.92860327
24RNA capping (GO:0036260)4.92860327
25termination of RNA polymerase I transcription (GO:0006363)4.86400223
26chaperone-mediated protein transport (GO:0072321)4.84163200
27aldehyde catabolic process (GO:0046185)4.80594994
28mitochondrial respiratory chain complex I assembly (GO:0032981)4.74274516
29NADH dehydrogenase complex assembly (GO:0010257)4.74274516
30mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.74274516
31mitochondrial respiratory chain complex assembly (GO:0033108)4.73840245
32negative regulation of epithelial to mesenchymal transition (GO:0010719)4.53685108
33establishment of protein localization to mitochondrial membrane (GO:0090151)4.52091802
34anatomical structure maturation (GO:0071695)4.49517954
35mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.23020579
36respiratory electron transport chain (GO:0022904)4.06204145
37response to dietary excess (GO:0002021)4.03992115
38pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.01252911
39electron transport chain (GO:0022900)3.95920104
40cellular ketone body metabolic process (GO:0046950)3.88780516
41cytochrome complex assembly (GO:0017004)3.85490643
42transcription-coupled nucleotide-excision repair (GO:0006283)3.82186530
43execution phase of apoptosis (GO:0097194)3.75307677
44respiratory chain complex IV assembly (GO:0008535)3.73739007
45positive regulation of DNA binding (GO:0043388)3.69916671
46protein neddylation (GO:0045116)3.69286008
47regulation of sterol transport (GO:0032371)3.67788351
48regulation of cholesterol transport (GO:0032374)3.67788351
49negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.64453388
50sialylation (GO:0097503)3.61287691
51proton transport (GO:0015992)3.59674574
52transcription elongation from RNA polymerase I promoter (GO:0006362)3.59238481
53hydrogen transport (GO:0006818)3.54794421
54pyrimidine nucleotide catabolic process (GO:0006244)3.50425595
55positive regulation of B cell differentiation (GO:0045579)3.43046541
56positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.36797832
57ketone body metabolic process (GO:1902224)3.34789043
58Leydig cell differentiation (GO:0033327)3.28001630
59viral life cycle (GO:0019058)3.27656609
60positive regulation of viral transcription (GO:0050434)3.25710102
61regulation of mitochondrial translation (GO:0070129)3.23183571
62ATP biosynthetic process (GO:0006754)3.22856207
63mitochondrion morphogenesis (GO:0070584)3.21399323
64ribosomal small subunit biogenesis (GO:0042274)3.21071704
65forebrain neuron development (GO:0021884)3.19285831
66establishment of mitochondrion localization (GO:0051654)3.18216953
67deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.17265885
68CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.15647846
69T-helper cell differentiation (GO:0042093)3.15647846
70transcription initiation from RNA polymerase I promoter (GO:0006361)3.14559630
71base-excision repair, AP site formation (GO:0006285)3.13987203
72DNA damage response, detection of DNA damage (GO:0042769)3.13908570
73peroxisome fission (GO:0016559)3.13315520
74intracellular protein transmembrane import (GO:0044743)3.10939967
75establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.10569924
76mitochondrion transport along microtubule (GO:0047497)3.10569924
77cellular protein complex disassembly (GO:0043624)3.09286887
78endosome organization (GO:0007032)3.05957982
79cerebral cortex neuron differentiation (GO:0021895)3.01663879
80viral transcription (GO:0019083)3.01555169
81platelet dense granule organization (GO:0060155)2.98033780
82grooming behavior (GO:0007625)2.96951945
83positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.95954864
84regulation of cilium movement (GO:0003352)2.95759089
85ribosomal small subunit assembly (GO:0000028)2.95017668
86protein targeting to mitochondrion (GO:0006626)2.94527784
87GTP biosynthetic process (GO:0006183)2.91555137
88DNA deamination (GO:0045006)2.90499624
89termination of RNA polymerase III transcription (GO:0006386)2.90266063
90transcription elongation from RNA polymerase III promoter (GO:0006385)2.90266063
91deoxyribonucleotide catabolic process (GO:0009264)2.89871989
92purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.88432185
93pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.88176713
94regulation of mitochondrial depolarization (GO:0051900)2.87834513
95regulation of tumor necrosis factor-mediated signaling pathway (GO:0010803)2.87504671
96purine nucleoside triphosphate biosynthetic process (GO:0009145)2.87362748
97transcription from RNA polymerase I promoter (GO:0006360)2.86663150
98energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.86660466
99ATP hydrolysis coupled proton transport (GO:0015991)2.86660466
100establishment of protein localization to mitochondrion (GO:0072655)2.85867600
101axoneme assembly (GO:0035082)2.85764626
102semaphorin-plexin signaling pathway (GO:0071526)2.85652749
103membrane budding (GO:0006900)2.81966213
104behavioral response to nicotine (GO:0035095)2.79037964
105translational termination (GO:0006415)2.77931761
106water-soluble vitamin biosynthetic process (GO:0042364)2.76138897
107oxidative phosphorylation (GO:0006119)2.75747594
108ubiquinone biosynthetic process (GO:0006744)2.74327194
109protein localization to mitochondrion (GO:0070585)2.74141703
110mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.73685236
111alpha-beta T cell activation involved in immune response (GO:0002287)2.71910966
112T cell differentiation involved in immune response (GO:0002292)2.71910966
113alpha-beta T cell differentiation involved in immune response (GO:0002293)2.71910966
114hydrogen ion transmembrane transport (GO:1902600)2.71680730
115tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.69314821
116RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.69314821
117protein-cofactor linkage (GO:0018065)2.69290341
118negative regulation of fibroblast apoptotic process (GO:2000270)2.68438730
119sequestering of actin monomers (GO:0042989)2.67222725
120nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.66447279
121response to food (GO:0032094)2.66246496
122SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.66049700
123bone mineralization (GO:0030282)2.65925305
124glutathione metabolic process (GO:0006749)2.65419973
125I-kappaB phosphorylation (GO:0007252)2.65082252
126cullin deneddylation (GO:0010388)2.64113636
127lysosome organization (GO:0007040)2.63800480
128lytic vacuole organization (GO:0080171)2.63800480
129protein targeting to ER (GO:0045047)2.63294230
130metallo-sulfur cluster assembly (GO:0031163)2.62121229
131iron-sulfur cluster assembly (GO:0016226)2.62121229
132viral protein processing (GO:0019082)2.61400545
133lung secretory cell differentiation (GO:0061140)2.60728709
134cotranslational protein targeting to membrane (GO:0006613)2.60263245
135* mitochondrial transport (GO:0006839)2.60170403
136deoxyribose phosphate catabolic process (GO:0046386)2.59725292
137negative regulation of response to food (GO:0032096)2.59589417
138negative regulation of appetite (GO:0032099)2.59589417
139translation (GO:0006412)2.57646776
140nucleoside triphosphate biosynthetic process (GO:0009142)2.57636987
141positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.57060308
142positive regulation of sodium ion transmembrane transport (GO:1902307)2.56977552
143anterograde synaptic vesicle transport (GO:0048490)2.56098729
144cholesterol homeostasis (GO:0042632)2.55551987
145purine nucleotide salvage (GO:0032261)2.55031128
146positive regulation of mitochondrial fission (GO:0090141)2.54848409
147translational initiation (GO:0006413)2.53650440
148establishment of protein localization to endoplasmic reticulum (GO:0072599)2.53459569
149epithelial cilium movement (GO:0003351)2.52317964
150negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.51853737
151intracellular protein transmembrane transport (GO:0065002)2.51320597
152ubiquinone metabolic process (GO:0006743)2.50660422
153protein localization to endoplasmic reticulum (GO:0070972)2.50351341
154protein deneddylation (GO:0000338)2.48490110
155regulation of catecholamine metabolic process (GO:0042069)2.47708708
156regulation of dopamine metabolic process (GO:0042053)2.47708708
157ribonucleoside triphosphate biosynthetic process (GO:0009201)2.47567597
158protein targeting to membrane (GO:0006612)2.47564989
159sterol homeostasis (GO:0055092)2.47175185
160protein complex disassembly (GO:0043241)2.46291005
161negative regulation of heart rate (GO:0010459)2.46238429
162protein localization to cilium (GO:0061512)2.45402403
163translational elongation (GO:0006414)2.45280628
164GPI anchor metabolic process (GO:0006505)2.42896847
165GPI anchor biosynthetic process (GO:0006506)2.42169411
166negative regulation of stem cell differentiation (GO:2000737)2.41890281
167seminiferous tubule development (GO:0072520)2.40829280
168preassembly of GPI anchor in ER membrane (GO:0016254)2.37554710
169positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.37470162
1702-deoxyribonucleotide metabolic process (GO:0009394)2.36386148
171macromolecular complex disassembly (GO:0032984)2.34863803
172axonemal dynein complex assembly (GO:0070286)2.33349788
173aerobic respiration (GO:0009060)2.33162309
174regulation of cholesterol esterification (GO:0010872)14.2836472
175erythrocyte maturation (GO:0043249)11.8070677

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IKZF1_21737484_ChIP-ChIP_HCT116_Human4.91805681
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.15128870
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.97269767
4PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.17281934
5GABP_17652178_ChIP-ChIP_JURKAT_Human2.95738011
6ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.89817359
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.78077350
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.77957491
9STAT1_20625510_ChIP-Seq_HELA_Human2.75456405
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.71980937
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.61566420
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.60420871
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.59869418
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.57703629
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.48588385
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.47011098
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.33188146
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.30969868
19NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.30476268
20LXR_22292898_ChIP-Seq_THP-1_Human2.27896721
21ETS1_20019798_ChIP-Seq_JURKAT_Human2.26985303
22PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.22104944
23RARG_19884340_ChIP-ChIP_MEFs_Mouse2.13787751
24PPARA_22158963_ChIP-Seq_LIVER_Mouse2.11917854
25RXR_22158963_ChIP-Seq_LIVER_Mouse1.97720348
26VDR_22108803_ChIP-Seq_LS180_Human1.96352516
27VDR_23849224_ChIP-Seq_CD4+_Human1.89959191
28CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.81802262
29BP1_19119308_ChIP-ChIP_Hs578T_Human1.80333448
30SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.78804706
31CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.76746719
32SRF_21415370_ChIP-Seq_HL-1_Mouse1.75830990
33EGR1_19032775_ChIP-ChIP_M12_Human1.72747091
34HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.71330500
35TET1_21451524_ChIP-Seq_MESCs_Mouse1.69765787
36ZNF274_21170338_ChIP-Seq_K562_Hela1.66795395
37IGF1R_20145208_ChIP-Seq_DFB_Human1.66086470
38BCL6_27268052_Chip-Seq_Bcells_Human1.65765998
39PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.63605170
40SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.58058309
41TRIM28_21343339_ChIP-Seq_HEK293_Human1.57291286
42CTCF_18555785_ChIP-Seq_MESCs_Mouse1.56271170
43CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.55190060
44EZH2_27294783_Chip-Seq_ESCs_Mouse1.54095531
45REST_18959480_ChIP-ChIP_MESCs_Mouse1.53050998
46BCOR_27268052_Chip-Seq_Bcells_Human1.52857065
47CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.52694638
48SRY_22984422_ChIP-ChIP_TESTIS_Rat1.50139629
49CTCF_27219007_Chip-Seq_Bcells_Human1.49438803
50TP63_17297297_ChIP-ChIP_HaCaT_Human1.48784166
51FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.48715077
52RAD21_21589869_ChIP-Seq_MESCs_Mouse1.47955348
53EZH2_27304074_Chip-Seq_ESCs_Mouse1.46362875
54REST_21632747_ChIP-Seq_MESCs_Mouse1.45789767
55CREB1_15753290_ChIP-ChIP_HEK293T_Human1.45327225
56P68_20966046_ChIP-Seq_HELA_Human1.41526127
57JARID2_20064375_ChIP-Seq_MESCs_Mouse1.40903866
58SUZ12_27294783_Chip-Seq_ESCs_Mouse1.40778664
59JARID2_20075857_ChIP-Seq_MESCs_Mouse1.40681978
60EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.40053223
61RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.39542879
62SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.39352477
63FOXP3_21729870_ChIP-Seq_TREG_Human1.39237621
64TP53_22573176_ChIP-Seq_HFKS_Human1.37897275
65HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.36049689
66CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.34901960
67BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.31408013
68CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.31215571
69HTT_18923047_ChIP-ChIP_STHdh_Human1.30445688
70THAP11_20581084_ChIP-Seq_MESCs_Mouse1.30235572
71NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.28578236
72OCT4_18692474_ChIP-Seq_MEFs_Mouse1.28390526
73FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.28371087
74TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27161086
75E2F1_20622854_ChIP-Seq_HELA_Human1.27091312
76ERG_21242973_ChIP-ChIP_JURKAT_Human1.25976790
77CSB_26484114_Chip-Seq_FIBROBLAST_Human1.25762297
78NANOG_20526341_ChIP-Seq_ESCs_Human1.25505478
79YY1_22570637_ChIP-Seq_MALME-3M_Human1.25432899
80TP53_22127205_ChIP-Seq_IMR90_Human1.24953849
81SA1_27219007_Chip-Seq_ERYTHROID_Human1.24496785
82IRF8_22096565_ChIP-ChIP_GC-B_Human1.24385624
83P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.24292909
84BMI1_23680149_ChIP-Seq_NPCS_Mouse1.24137599
85EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.23923428
86FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.23854394
87CTCF_20526341_ChIP-Seq_ESCs_Human1.23836581
88YY1_21170310_ChIP-Seq_MESCs_Mouse1.23823524
89DNAJC2_21179169_ChIP-ChIP_NT2_Human1.22962562
90PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.20703108
91SA1_27219007_Chip-Seq_Bcells_Human1.20669656
92PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.20316918
93RACK7_27058665_Chip-Seq_MCF-7_Human1.20029885
94CLOCK_20551151_ChIP-Seq_293T_Human1.19159612
95EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.18708349
96SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.18254525
97THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.17910005
98ELF1_20517297_ChIP-Seq_JURKAT_Human1.17476735
99CBX2_27304074_Chip-Seq_ESCs_Mouse1.16576230
100HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.15908785
101GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15123597
102MYC_19829295_ChIP-Seq_ESCs_Human1.14561953
103ETV2_25802403_ChIP-Seq_MESCs_Mouse1.13723945
104GABP_19822575_ChIP-Seq_HepG2_Human1.12471246
105SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.12239948
106CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.12130944
107JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.11395663
108PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11090979
109CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.10291842
110ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.09996311
111SOX2_22085726_ChIP-Seq_NPCs_Mouse1.09888859
112TAF2_19829295_ChIP-Seq_ESCs_Human1.09223090
113VDR_21846776_ChIP-Seq_THP-1_Human1.09214298
114ZFP281_18757296_ChIP-ChIP_E14_Mouse1.08676618
115CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07889959
116FOXP1_21924763_ChIP-Seq_HESCs_Human1.07260260
117ERG_20517297_ChIP-Seq_VCAP_Human1.06930203
118SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.05692115
119BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.05249123
120SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.04795282
121LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.04245428
122GATA3_21878914_ChIP-Seq_MCF-7_Human1.04206469
123GATA3_21867929_ChIP-Seq_CD8_Mouse1.03286576
124MYC_18940864_ChIP-ChIP_HL60_Human1.03272592
125SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.03209229
126ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.02734429
127STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.02631218
128EZH2_22144423_ChIP-Seq_EOC_Human1.02099853
129NCOR_22424771_ChIP-Seq_293T_Human1.01709020
130EED_16625203_ChIP-ChIP_MESCs_Mouse1.01458667
131GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01353908
132AR_20517297_ChIP-Seq_VCAP_Human1.00850002
133EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.00181633
134MYC_18555785_ChIP-Seq_MESCs_Mouse0.99657037
135RAC3_21632823_ChIP-Seq_H3396_Human0.96868389
136SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.96527083
137MYC_19915707_ChIP-ChIP_AK7_Human0.96488676
138LXR_22158963_ChIP-Seq_LIVER_Mouse0.96413252
139SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.96341751
140* CIITA_25753668_ChIP-Seq_RAJI_Human0.95950618
141CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.95832391
142ERA_21632823_ChIP-Seq_H3396_Human0.95011007
143CTCF_26484167_Chip-Seq_Bcells_Mouse0.94746002
144FOXA1_25329375_ChIP-Seq_VCAP_Human0.93224584
145FOXA1_27270436_Chip-Seq_PROSTATE_Human0.93224584
146SOX2_18692474_ChIP-Seq_MEFs_Mouse0.92720811
147FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.92264479
148SOX2_21211035_ChIP-Seq_LN229_Human0.91801502
149PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.91264239
150P300_27268052_Chip-Seq_Bcells_Human0.90643343
151ELK1_22589737_ChIP-Seq_MCF10A_Human0.90384823
152MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.90267178
153OCT4_20526341_ChIP-Seq_ESCs_Human0.90119765
154MYC_18358816_ChIP-ChIP_MESCs_Mouse0.89996411
155XRN2_22483619_ChIP-Seq_HELA_Human0.89606058
156ZFP57_27257070_Chip-Seq_ESCs_Mouse0.87004519
157FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86855592
158LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.86643314
159CTBP1_25329375_ChIP-Seq_LNCAP_Human0.85544689
160SOX2_19829295_ChIP-Seq_ESCs_Human0.85314093
161NANOG_19829295_ChIP-Seq_ESCs_Human0.85314093

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000013_abnormal_adipose_tissue9.91034959
2MP0005377_hearing/vestibular/ear_phenot5.83309679
3MP0003878_abnormal_ear_physiology5.83309679
4MP0002938_white_spotting5.46648077
5MP0002102_abnormal_ear_morphology5.20908694
6MP0000003_abnormal_adipose_tissue3.79433611
7MP0010307_abnormal_tumor_latency3.33088837
8MP0003879_abnormal_hair_cell2.94515807
9MP0003786_premature_aging2.93827768
10MP0000749_muscle_degeneration2.84418921
11MP0001485_abnormal_pinna_reflex2.48449614
12MP0005332_abnormal_amino_acid2.41956770
13MP0003787_abnormal_imprinting2.29119817
14MP0003011_delayed_dark_adaptation2.20410020
15MP0005360_urolithiasis1.99159567
16MP0004742_abnormal_vestibular_system1.98968351
17MP0002653_abnormal_ependyma_morphology1.98805348
18MP0004145_abnormal_muscle_electrophysio1.93583226
19MP0003880_abnormal_central_pattern1.91858224
20MP0005646_abnormal_pituitary_gland1.91343099
21MP0009046_muscle_twitch1.85578721
22MP0002736_abnormal_nociception_after1.76352717
23MP0001984_abnormal_olfaction1.73781011
24MP0000372_irregular_coat_pigmentation1.73111083
25MP0002909_abnormal_adrenal_gland1.69435028
26MP0009745_abnormal_behavioral_response1.68192652
27MP0002163_abnormal_gland_morphology1.66024907
28MP0005375_adipose_tissue_phenotype1.65134389
29MP0003806_abnormal_nucleotide_metabolis1.63470799
30MP0003866_abnormal_defecation1.61152506
31MP0005379_endocrine/exocrine_gland_phen1.61134219
32MP0006072_abnormal_retinal_apoptosis1.57200292
33MP0002876_abnormal_thyroid_physiology1.55752178
34MP0005501_abnormal_skin_physiology1.55007861
35MP0004859_abnormal_synaptic_plasticity1.52927227
36MP0002139_abnormal_hepatobiliary_system1.52465267
37MP0003122_maternal_imprinting1.52212232
38MP0005365_abnormal_bile_salt1.50712328
39MP0002277_abnormal_respiratory_mucosa1.49761935
40MP0006036_abnormal_mitochondrial_physio1.48947258
41MP0006276_abnormal_autonomic_nervous1.47531015
42MP0002064_seizures1.45070426
43MP0005423_abnormal_somatic_nervous1.44477311
44MP0008789_abnormal_olfactory_epithelium1.44101617
45MP0002837_dystrophic_cardiac_calcinosis1.43279630
46MP0003635_abnormal_synaptic_transmissio1.40807827
47MP0003123_paternal_imprinting1.39294139
48MP0005085_abnormal_gallbladder_physiolo1.32654246
49MP0001986_abnormal_taste_sensitivity1.31466591
50MP0008872_abnormal_physiological_respon1.29672521
51MP0002557_abnormal_social/conspecific_i1.26640137
52MP0004147_increased_porphyrin_level1.26128903
53MP0002734_abnormal_mechanical_nocicepti1.25416070
54MP0000751_myopathy1.24951060
55MP0000631_abnormal_neuroendocrine_gland1.24037130
56MP0005671_abnormal_response_to1.23713079
57MP0001501_abnormal_sleep_pattern1.23159425
58MP0008877_abnormal_DNA_methylation1.22695550
59MP0005394_taste/olfaction_phenotype1.21600072
60MP0005499_abnormal_olfactory_system1.21600072
61MP0001835_abnormal_antigen_presentation1.21587584
62MP0009840_abnormal_foam_cell1.21395584
63MP0003646_muscle_fatigue1.20447515
64MP0002148_abnormal_hypersensitivity_rea1.19410802
65MP0008875_abnormal_xenobiotic_pharmacok1.15875000
66MP0005075_abnormal_melanosome_morpholog1.15076861
67MP0003121_genomic_imprinting1.09283253
68MP0002693_abnormal_pancreas_physiology1.05886638
69MP0003195_calcinosis1.05693180
70MP0001440_abnormal_grooming_behavior1.05580199
71MP0001486_abnormal_startle_reflex1.05054362
72MP0006035_abnormal_mitochondrial_morpho1.03916785
73MP0001764_abnormal_homeostasis1.03889351
74MP0001879_abnormal_lymphatic_vessel1.03365174
75MP0006292_abnormal_olfactory_placode0.99776482
76MP0004885_abnormal_endolymph0.99223691
77MP0002138_abnormal_hepatobiliary_system0.94344858
78MP0005386_behavior/neurological_phenoty0.94012548
79MP0004924_abnormal_behavior0.94012548
80MP0005551_abnormal_eye_electrophysiolog0.94007428
81MP0004043_abnormal_pH_regulation0.92738181
82MP0010386_abnormal_urinary_bladder0.91386390
83MP0001944_abnormal_pancreas_morphology0.90539869
84MP0003303_peritoneal_inflammation0.89934679
85MP0003724_increased_susceptibility_to0.89831561
86MP0004215_abnormal_myocardial_fiber0.89592566
87MP0001968_abnormal_touch/_nociception0.89570369
88MP0008873_increased_physiological_sensi0.88761240
89MP0003186_abnormal_redox_activity0.86646009
90MP0002572_abnormal_emotion/affect_behav0.86293060
91MP0005508_abnormal_skeleton_morphology0.86038571
92MP0000230_abnormal_systemic_arterial0.83712418
93MP0004133_heterotaxia0.79087507
94MP0002078_abnormal_glucose_homeostasis0.78546961
95MP0003137_abnormal_impulse_conducting0.78372055
96MP0001502_abnormal_circadian_rhythm0.76634957
97MP0005174_abnormal_tail_pigmentation0.76342487
98MP0001919_abnormal_reproductive_system0.75567993
99MP0009643_abnormal_urine_homeostasis0.74761683
100MP0000026_abnormal_inner_ear0.74245328
101MP0002095_abnormal_skin_pigmentation0.74226243
102MP0005448_abnormal_energy_balance0.73637732
103MP0002067_abnormal_sensory_capabilities0.71779503
104MP0003329_amyloid_beta_deposits0.69772340
105MP0002735_abnormal_chemical_nociception0.68110327
106MP0005636_abnormal_mineral_homeostasis0.68056166
107MP0002638_abnormal_pupillary_reflex0.67460062
108MP0004036_abnormal_muscle_relaxation0.66668931
109MP0001905_abnormal_dopamine_level0.66232532
110MP0002229_neurodegeneration0.64676779
111MP0002733_abnormal_thermal_nociception0.63849338
112MP0004134_abnormal_chest_morphology0.63800338
113MP0002822_catalepsy0.63388626
114MP0005535_abnormal_body_temperature0.62905805
115MP0005083_abnormal_biliary_tract0.62829473
116MP0003959_abnormal_lean_body0.61198850
117MP0002063_abnormal_learning/memory/cond0.59861767
118MP0005253_abnormal_eye_physiology0.57922451
119MP0005645_abnormal_hypothalamus_physiol0.56008556
120MP0000747_muscle_weakness0.54700427
121MP0005084_abnormal_gallbladder_morpholo0.54262521
122MP0005390_skeleton_phenotype0.52817100
123MP0001756_abnormal_urination0.51770415
124MP0002282_abnormal_trachea_morphology0.51663297
125MP0002972_abnormal_cardiac_muscle0.51596757
126MP0000377_abnormal_hair_follicle0.50243478
127MP0004142_abnormal_muscle_tone0.50237580
128MP0001529_abnormal_vocalization0.50163921
129MP0008058_abnormal_DNA_repair0.49701461
130MP0009785_altered_susceptibility_to0.49401444
131MP0009379_abnormal_foot_pigmentation0.49373298
132MP0003950_abnormal_plasma_membrane0.48739269
133MP0008995_early_reproductive_senescence0.46673522
134MP0001324_abnormal_eye_pigmentation0.46410225
135MP0003436_decreased_susceptibility_to0.46113311
136MP0010771_integument_phenotype0.45732044
137MP0005193_abnormal_anterior_eye0.44724006
138MP0001666_abnormal_nutrient_absorption0.44431402
139MP0002272_abnormal_nervous_system0.44235368
140MP0000681_abnormal_thyroid_gland0.44182822
141MP0004019_abnormal_vitamin_homeostasis0.43107838
142MP0000538_abnormal_urinary_bladder0.40980965
143MP0001663_abnormal_digestive_system0.40446472
144MP0005584_abnormal_enzyme/coenzyme_acti0.39731041
145MP0005257_abnormal_intraocular_pressure0.39507854
146MP0000604_amyloidosis0.39486457
147MP0001963_abnormal_hearing_physiology0.39075299
148MP0005058_abnormal_lysosome_morphology0.38968758
149MP0003191_abnormal_cellular_cholesterol0.37049657
150MP0002332_abnormal_exercise_endurance0.36710727
151MP0004270_analgesia0.35913479
152MP0003633_abnormal_nervous_system0.35502975
153MP0001970_abnormal_pain_threshold0.35455427
154MP0001765_abnormal_ion_homeostasis0.35127358
155MP0002405_respiratory_system_inflammati0.35004501
156MP0000762_abnormal_tongue_morphology0.34856151

Predicted human phenotypes

RankGene SetZ-score
1Entropion (HP:0000621)9.80372107
2Congenital nonbullous ichthyosiform erythroderma (HP:0007479)9.14822158
3Poikiloderma (HP:0001029)9.14163489
4Fragile nails (HP:0001808)7.40258259
5Decreased subcutaneous fat (HP:0001002)7.31347601
6Abnormality of DNA repair (HP:0003254)6.19751580
7Congenital ichthyosiform erythroderma (HP:0007431)5.93728052
8Prominent metopic ridge (HP:0005487)5.92674626
9Erythroderma (HP:0001019)5.76434552
10Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)5.73867501
11Generalized aminoaciduria (HP:0002909)5.44776966
12Abnormality of subcutaneous fat tissue (HP:0001001)5.25593443
13Abnormality of the metopic suture (HP:0005556)5.11446157
14Death in childhood (HP:0003819)4.85637238
15Conjunctival hamartoma (HP:0100780)4.57882278
16Renal Fanconi syndrome (HP:0001994)4.45105459
17Brittle hair (HP:0002299)4.29145131
18Cone-rod dystrophy (HP:0000548)3.89606401
19Lipid accumulation in hepatocytes (HP:0006561)3.80563778
20Increased hepatocellular lipid droplets (HP:0006565)3.71385464
21Male infertility (HP:0003251)3.69096852
22Ectropion (HP:0000656)3.64211798
23Increased intramyocellular lipid droplets (HP:0012240)3.52240675
24Increased muscle lipid content (HP:0009058)3.38554966
25Progressive macrocephaly (HP:0004481)3.37993616
26Hypophosphatemic rickets (HP:0004912)3.24886822
27Abnormality of fatty-acid metabolism (HP:0004359)3.15048855
28Failure to thrive in infancy (HP:0001531)3.04463291
29Myokymia (HP:0002411)2.98804221
30Keratitis (HP:0000491)2.94417835
31Lactic acidosis (HP:0003128)2.94366619
32Recurrent corneal erosions (HP:0000495)2.92644940
33Abnormality of the costochondral junction (HP:0000919)2.92221100
34Respiratory failure (HP:0002878)2.91330236
35Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.89326106
36Polyphagia (HP:0002591)2.86520454
37IgG deficiency (HP:0004315)2.81928060
38Decreased activity of mitochondrial respiratory chain (HP:0008972)2.81529239
39Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.81529239
40Exertional dyspnea (HP:0002875)2.79112454
41Abnormality of renal resorption (HP:0011038)2.78740662
42Stomach cancer (HP:0012126)2.78298309
43Choreoathetosis (HP:0001266)2.73639043
44Exercise intolerance (HP:0003546)2.72558370
45Abnormality of urine glucose concentration (HP:0011016)2.70829019
46Glycosuria (HP:0003076)2.70829019
47Abnormal respiratory epithelium morphology (HP:0012253)2.67167572
48Abnormal respiratory motile cilium morphology (HP:0005938)2.67167572
49Abnormal ciliary motility (HP:0012262)2.63676384
50Hamartoma of the eye (HP:0010568)2.62565913
51Neonatal respiratory distress (HP:0002643)2.60286094
52Optic disc pallor (HP:0000543)2.58597586
53Abnormal respiratory motile cilium physiology (HP:0012261)2.58160850
54Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.58037794
55Acute necrotizing encephalopathy (HP:0006965)2.57584716
56Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.50646574
57Dicarboxylic aciduria (HP:0003215)2.46999394
58Abnormality of dicarboxylic acid metabolism (HP:0010995)2.46999394
59Medial flaring of the eyebrow (HP:0010747)2.45140163
60Methylmalonic aciduria (HP:0012120)2.44466380
61Megalencephaly (HP:0001355)2.43445881
62Abnormality of cells of the erythroid lineage (HP:0012130)2.41934895
63Polydipsia (HP:0001959)2.41165651
64Abnormal drinking behavior (HP:0030082)2.41165651
65Poor eye contact (HP:0000817)2.40719426
66Increased serum lactate (HP:0002151)2.38412644
67Molar tooth sign on MRI (HP:0002419)2.35728091
68Abnormality of midbrain morphology (HP:0002418)2.35728091
69Abnormal mitochondria in muscle tissue (HP:0008316)2.33903010
70Methylmalonic acidemia (HP:0002912)2.33363494
71Congenital stationary night blindness (HP:0007642)2.29930603
72Abnormal number of erythroid precursors (HP:0012131)2.29703732
73Acute encephalopathy (HP:0006846)2.28501506
74Subacute progressive viral hepatitis (HP:0006572)2.28347433
75Lethargy (HP:0001254)2.27679351
76Mitochondrial inheritance (HP:0001427)2.27001705
77Gait imbalance (HP:0002141)2.24269145
78Bone cyst (HP:0012062)2.24265996
79Leukodystrophy (HP:0002415)2.21563975
80Hyponatremia (HP:0002902)2.20776682
81Pancreatic cysts (HP:0001737)2.19964393
82Dynein arm defect of respiratory motile cilia (HP:0012255)2.18775622
83Absent/shortened dynein arms (HP:0200106)2.18775622
84Poor suck (HP:0002033)2.15887420
85Macrocytic anemia (HP:0001972)2.14294951
86Limb dystonia (HP:0002451)2.13113380
87Multiple lipomas (HP:0001012)2.12823295
88Abnormal rod and cone electroretinograms (HP:0008323)2.10007307
89Hyperphosphaturia (HP:0003109)2.07413912
90Angiofibromas (HP:0010615)2.06560052
91Adenoma sebaceum (HP:0009720)2.06560052
92Pancreatic fibrosis (HP:0100732)2.05547811
93Goiter (HP:0000853)2.04981266
94Agitation (HP:0000713)2.03789101
95Absent rod-and cone-mediated responses on ERG (HP:0007688)2.03697239
96Congenital primary aphakia (HP:0007707)2.02142216
97Respiratory difficulties (HP:0002880)2.01752184
98Hepatic necrosis (HP:0002605)2.00071245
99Thickened helices (HP:0000391)1.99019252
100True hermaphroditism (HP:0010459)1.98859323
101Ketosis (HP:0001946)1.98335621
102Abnormality of aromatic amino acid family metabolism (HP:0004338)1.97012540
103Hyperglycinemia (HP:0002154)1.95958331
104Emotional lability (HP:0000712)1.95139341
105Hypoglycemic coma (HP:0001325)1.94454734
106Nephrogenic diabetes insipidus (HP:0009806)1.93099393
107Cavernous hemangioma (HP:0001048)1.90216590
108Type 2 muscle fiber atrophy (HP:0003554)1.89565017
109Cutaneous photosensitivity (HP:0000992)1.89528616
110X-linked dominant inheritance (HP:0001423)1.89363666
111Rhinitis (HP:0012384)1.89298894
112Increased CSF lactate (HP:0002490)1.88244661
113Overgrowth (HP:0001548)1.88118681
114Scrotal hypoplasia (HP:0000046)1.87293492
115Large earlobe (HP:0009748)1.86741354
116Cerebral edema (HP:0002181)1.86280245
117Hepatocellular necrosis (HP:0001404)1.85892364
118Nephronophthisis (HP:0000090)1.85541540
119Progressive neurologic deterioration (HP:0002344)1.84962188
120Ketoacidosis (HP:0001993)1.82796730
121Impaired social interactions (HP:0000735)1.82441764
122Abnormal social behavior (HP:0012433)1.82441764
123Polyuria (HP:0000103)1.82037883
124Abnormal eating behavior (HP:0100738)1.81937420
125CNS demyelination (HP:0007305)1.80644998
126Exocrine pancreatic insufficiency (HP:0001738)1.79915714
127Muscle fiber atrophy (HP:0100295)1.79483864
128Abnormality of sodium homeostasis (HP:0010931)1.78772153
129Type I diabetes mellitus (HP:0100651)1.78343265
130Abnormality of sulfur amino acid metabolism (HP:0004339)1.78175296
131Hypokalemia (HP:0002900)1.78129676
132Visceral angiomatosis (HP:0100761)1.78021384
133Vacuolated lymphocytes (HP:0001922)1.77099276
134Abnormality of vitamin B metabolism (HP:0004340)1.74839604
135Macular degeneration (HP:0000608)1.73904835
136Irritability (HP:0000737)1.72044067
137Abnormal urine output (HP:0012590)1.71033012
138Rickets (HP:0002748)1.69546347
139Stomatitis (HP:0010280)1.69395528
140Fetal akinesia sequence (HP:0001989)1.68498823
141Deep palmar crease (HP:0006191)1.68096475
142Cerebral palsy (HP:0100021)1.66979629
143Type II lissencephaly (HP:0007260)1.66015507
144Conjugated hyperbilirubinemia (HP:0002908)1.65961478
145Hyperthyroidism (HP:0000836)1.65576002
146Progressive visual loss (HP:0000529)1.64937198
147Vomiting (HP:0002013)1.64820116
148Decreased circulating renin level (HP:0003351)1.64231340
149Thyroid-stimulating hormone excess (HP:0002925)1.63923237
150Delayed CNS myelination (HP:0002188)1.62196720
151Hypomagnesemia (HP:0002917)1.61596247
152Aplasia/Hypoplasia of the sacrum (HP:0008517)1.61305209
153Hepatocellular carcinoma (HP:0001402)1.60937809
154Maternal diabetes (HP:0009800)1.60898388
155Muscle hypertrophy of the lower extremities (HP:0008968)1.60140447
156Progressive microcephaly (HP:0000253)1.59409656
157Abolished electroretinogram (ERG) (HP:0000550)1.57254256
158Petechiae (HP:0000967)1.55472365
159Oligomenorrhea (HP:0000876)1.55150426
160Decreased electroretinogram (ERG) amplitude (HP:0000654)1.54055429
161Prolonged QT interval (HP:0001657)1.54040777
162Bile duct proliferation (HP:0001408)1.52596284
163Abnormal biliary tract physiology (HP:0012439)1.52596284
164Abnormality of magnesium homeostasis (HP:0004921)1.52249039
165Alveolar cell carcinoma (HP:0006519)1.51745067
166Hemangiomatosis (HP:0007461)1.51549283
167Meningioma (HP:0002858)1.51181180
168Asthma (HP:0002099)1.50858836
169Abnormality of the septum pellucidum (HP:0007375)1.49904141
1703-Methylglutaconic aciduria (HP:0003535)1.48660490
171Mucosal telangiectasiae (HP:0100579)1.47322152
172Nephroblastoma (Wilms tumor) (HP:0002667)1.46285252
173Arthrogryposis multiplex congenita (HP:0002804)1.45989609
174Abnormality of renal excretion (HP:0011036)1.45208742

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK27.24183059
2PINK15.18253918
3BRAF5.03880487
4TAOK14.52471582
5MAP2K23.41376528
6NME23.13927666
7BUB12.91603417
8LIMK12.80927396
9MAP4K22.59817146
10STK162.23934006
11INSRR2.11399481
12ADRBK21.98281208
13FRK1.81142465
14MAPK131.78553516
15BCKDK1.76186155
16TESK11.73327753
17MAP3K81.66183809
18VRK21.60850350
19GRK11.57361985
20CSNK1G31.49360790
21MAP2K71.48386330
22MST41.42124987
23TRIM281.36329438
24CSNK1G21.36251845
25MAP3K41.35686512
26TXK1.34277041
27TLK11.33453338
28CDK191.33185911
29DAPK21.31970827
30NME11.31891142
31MUSK1.31159573
32TNK21.29480775
33TAOK31.27865724
34ABL21.18423971
35CAMKK21.18280875
36MYLK1.17713301
37EPHB11.12154969
38MINK11.11054157
39ILK1.10445007
40PHKG21.09280574
41PHKG11.09280574
42OXSR11.08474233
43TESK21.07161890
44LMTK21.06091838
45CSNK1G11.05507397
46DMPK1.04460921
47PRKCG1.02179248
48PBK0.99802301
49PIM20.98933468
50KDR0.97478299
51VRK10.96677398
52WNK40.95223765
53RPS6KA50.94298733
54CSNK1A1L0.91810970
55PKN10.91651835
56CAMK2D0.89821244
57ERN10.89736504
58ARAF0.87742888
59ZAK0.87417078
60DYRK20.87227243
61MST1R0.85910738
62CASK0.85163809
63CAMKK10.83029019
64MAP2K60.82504795
65MARK10.80386546
66PRKCQ0.78727981
67CDK140.77720969
68PDPK10.77500751
69DAPK30.76784825
70PIK3CA0.76690071
71RIPK40.75798125
72CCNB10.75475172
73MKNK20.75437968
74CAMK10.75342215
75DAPK10.73807458
76NUAK10.73295192
77BMPR1B0.72921259
78MAPKAPK30.72135368
79IKBKB0.72069478
80NTRK20.70277311
81STK390.70101531
82IKBKE0.68849656
83DYRK1B0.68001258
84TEC0.67830826
85OBSCN0.67592201
86PRKG20.67527595
87PRKACA0.66740592
88CAMK2B0.66235329
89CAMK2G0.63709546
90ADRBK10.62805112
91CLK10.61321518
92PIK3CG0.61312813
93KIT0.59417341
94ERBB20.58952975
95TTN0.58058367
96UHMK10.58032704
97BLK0.57763596
98MAPK120.57526001
99EPHA40.57140899
100BTK0.55585360
101CSNK1A10.55045019
102MAP2K40.54806100
103SIK20.54455610
104GRK50.54274890
105DYRK30.51529889
106AURKA0.51257818
107PRKD20.51075181
108CDK150.51022740
109PDK10.49673656
110ITK0.49575807
111CDK180.49451574
112PRKCA0.48652115
113PAK30.48111387
114MAP3K110.47516278
115MAPKAPK50.46979201
116STK40.44976200
117CDK11A0.44491981
118PRKG10.43104550
119ROCK20.42484390
120CDK80.42018693
121CDK50.40472534
122TBK10.40432995
123GRK70.39278722
124CAMK2A0.36233021
125RAF10.36106350
126LRRK20.35630841
127WNK30.35381664
128MAPK40.35183428
129SYK0.34316848
130PRKCE0.33426011
131FES0.32597882
132PRKCI0.31187676
133MAP4K10.31149697
134MAP3K120.31126562
135NTRK10.31108573
136TGFBR10.30940914
137GRK60.30389852
138STK110.29269532
139MARK30.29030369
140TNIK0.27370116
141LYN0.26756726
142PKN20.26359639
143PRKD10.25999016
144CSK0.25324079
145PAK10.25066943
146NTRK30.24215626
147TGFBR20.24047484
148MATK0.23625732
149PAK20.22414778
150MAPK150.22231966

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.72279008
2Parkinsons disease_Homo sapiens_hsa050124.05629311
3Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.79243434
4Nucleotide excision repair_Homo sapiens_hsa034203.43141241
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.33004806
6Alzheimers disease_Homo sapiens_hsa050102.94706033
7Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.90773311
8SNARE interactions in vesicular transport_Homo sapiens_hsa041302.86379455
9Ribosome_Homo sapiens_hsa030102.79594363
10Huntingtons disease_Homo sapiens_hsa050162.67887518
11RNA polymerase_Homo sapiens_hsa030202.26900138
12Cardiac muscle contraction_Homo sapiens_hsa042602.20755658
13Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.19371047
14Sulfur metabolism_Homo sapiens_hsa009202.16920508
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.01303748
16Basal transcription factors_Homo sapiens_hsa030221.91976104
17Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.76262609
18Butanoate metabolism_Homo sapiens_hsa006501.74780521
19Asthma_Homo sapiens_hsa053101.73471683
20Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.55184645
21Type I diabetes mellitus_Homo sapiens_hsa049401.53596057
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.41053094
23Fructose and mannose metabolism_Homo sapiens_hsa000511.40793969
24Synaptic vesicle cycle_Homo sapiens_hsa047211.37956226
25Mismatch repair_Homo sapiens_hsa034301.32450049
26DNA replication_Homo sapiens_hsa030301.32342883
27Nicotine addiction_Homo sapiens_hsa050331.32141238
28Prion diseases_Homo sapiens_hsa050201.31189978
29Phototransduction_Homo sapiens_hsa047441.27492814
30Allograft rejection_Homo sapiens_hsa053301.26158956
31Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.24938526
32Histidine metabolism_Homo sapiens_hsa003401.22792281
33Regulation of autophagy_Homo sapiens_hsa041401.20226433
34Pentose and glucuronate interconversions_Homo sapiens_hsa000401.19153984
35Autoimmune thyroid disease_Homo sapiens_hsa053201.18742360
36Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.17818066
37Tryptophan metabolism_Homo sapiens_hsa003801.11106252
38Carbon metabolism_Homo sapiens_hsa012001.07928660
39Protein export_Homo sapiens_hsa030601.06963665
40Primary bile acid biosynthesis_Homo sapiens_hsa001201.05135617
41Fatty acid elongation_Homo sapiens_hsa000621.04331741
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.03301043
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.03263782
44Linoleic acid metabolism_Homo sapiens_hsa005911.03137030
45Primary immunodeficiency_Homo sapiens_hsa053401.02394302
46Glutathione metabolism_Homo sapiens_hsa004801.00231939
47Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.99937722
48Graft-versus-host disease_Homo sapiens_hsa053320.99577020
49Maturity onset diabetes of the young_Homo sapiens_hsa049500.99327181
50Phenylalanine metabolism_Homo sapiens_hsa003600.98864834
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.98682695
52Rheumatoid arthritis_Homo sapiens_hsa053230.97974482
53GABAergic synapse_Homo sapiens_hsa047270.96806984
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.95887173
55Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.93157835
56Folate biosynthesis_Homo sapiens_hsa007900.92885343
57Arginine and proline metabolism_Homo sapiens_hsa003300.92617813
58Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.92579525
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.90058116
60Fat digestion and absorption_Homo sapiens_hsa049750.88223888
61Proteasome_Homo sapiens_hsa030500.87285051
62Insulin secretion_Homo sapiens_hsa049110.86269642
63Pyrimidine metabolism_Homo sapiens_hsa002400.85235667
64Morphine addiction_Homo sapiens_hsa050320.84217907
65Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.83778188
66Arginine biosynthesis_Homo sapiens_hsa002200.80511218
672-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.80455566
68Peroxisome_Homo sapiens_hsa041460.79614886
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.78947807
70Chemical carcinogenesis_Homo sapiens_hsa052040.78502267
71Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.78131331
72Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.78084533
73Fatty acid degradation_Homo sapiens_hsa000710.77019300
74Pyruvate metabolism_Homo sapiens_hsa006200.76655977
75Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.74444115
76Circadian entrainment_Homo sapiens_hsa047130.74066907
77Drug metabolism - other enzymes_Homo sapiens_hsa009830.71589488
78Cyanoamino acid metabolism_Homo sapiens_hsa004600.71542297
79Propanoate metabolism_Homo sapiens_hsa006400.69479606
80Purine metabolism_Homo sapiens_hsa002300.68553844
81Vibrio cholerae infection_Homo sapiens_hsa051100.65426143
82Metabolic pathways_Homo sapiens_hsa011000.64443971
83Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.63999209
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.63887281
85Dopaminergic synapse_Homo sapiens_hsa047280.63629496
86VEGF signaling pathway_Homo sapiens_hsa043700.62471771
87Nitrogen metabolism_Homo sapiens_hsa009100.61989043
88Serotonergic synapse_Homo sapiens_hsa047260.60313939
89beta-Alanine metabolism_Homo sapiens_hsa004100.59787454
90Amphetamine addiction_Homo sapiens_hsa050310.59701490
91Renal cell carcinoma_Homo sapiens_hsa052110.59145705
92Collecting duct acid secretion_Homo sapiens_hsa049660.58983658
93Olfactory transduction_Homo sapiens_hsa047400.57023783
94Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.56489323
95Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.55444826
96Ether lipid metabolism_Homo sapiens_hsa005650.54846085
97Tyrosine metabolism_Homo sapiens_hsa003500.53900506
98Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51790959
99Thyroid cancer_Homo sapiens_hsa052160.51361815
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49752734
101Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.49140250
102Central carbon metabolism in cancer_Homo sapiens_hsa052300.48233447
103Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44518173
104Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.44488830
105Retinol metabolism_Homo sapiens_hsa008300.41341784
106PPAR signaling pathway_Homo sapiens_hsa033200.41299611
107Melanoma_Homo sapiens_hsa052180.40522340
108Steroid hormone biosynthesis_Homo sapiens_hsa001400.39483523
109Sphingolipid signaling pathway_Homo sapiens_hsa040710.39076275
110Glutamatergic synapse_Homo sapiens_hsa047240.37791680
111Starch and sucrose metabolism_Homo sapiens_hsa005000.37491941
112Staphylococcus aureus infection_Homo sapiens_hsa051500.37053653
113Complement and coagulation cascades_Homo sapiens_hsa046100.36782071
114Phagosome_Homo sapiens_hsa041450.36536253
115Renin secretion_Homo sapiens_hsa049240.36531240
116Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.36338384
117Systemic lupus erythematosus_Homo sapiens_hsa053220.35576316
118Taste transduction_Homo sapiens_hsa047420.35408225
119Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.34789934
120Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.34506102
121Bladder cancer_Homo sapiens_hsa052190.34317820
122Calcium signaling pathway_Homo sapiens_hsa040200.33836821
123Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.33529535
124Salivary secretion_Homo sapiens_hsa049700.32613378
125Arachidonic acid metabolism_Homo sapiens_hsa005900.31981273
126RNA degradation_Homo sapiens_hsa030180.28123278
127Lysosome_Homo sapiens_hsa041420.28023760
128Antigen processing and presentation_Homo sapiens_hsa046120.28019184
129Alcoholism_Homo sapiens_hsa050340.27553401
130Cocaine addiction_Homo sapiens_hsa050300.26965719
131Biosynthesis of amino acids_Homo sapiens_hsa012300.26892865
132HIF-1 signaling pathway_Homo sapiens_hsa040660.26508851
133Acute myeloid leukemia_Homo sapiens_hsa052210.25999015
134Inositol phosphate metabolism_Homo sapiens_hsa005620.22854451
135Fatty acid metabolism_Homo sapiens_hsa012120.21832343
136Gap junction_Homo sapiens_hsa045400.19294317
137Cysteine and methionine metabolism_Homo sapiens_hsa002700.18502695
138Type II diabetes mellitus_Homo sapiens_hsa049300.18320231
139Sulfur relay system_Homo sapiens_hsa041220.18313895
140Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.18283601
141Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.16984939
142Caffeine metabolism_Homo sapiens_hsa002320.16896690
143Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.16572687
144Mineral absorption_Homo sapiens_hsa049780.16032431

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