SMG1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)5.36173164
2cellular response to ethanol (GO:0071361)5.18760746
3histone H3-K4 trimethylation (GO:0080182)4.97626591
4monoubiquitinated protein deubiquitination (GO:0035520)4.88553401
5positive regulation of developmental pigmentation (GO:0048087)4.76084018
6regulation of pigment cell differentiation (GO:0050932)4.52289394
7regulation of B cell receptor signaling pathway (GO:0050855)4.49970108
8positive regulation of granulocyte differentiation (GO:0030854)4.43992520
9positive regulation of gamma-delta T cell activation (GO:0046645)4.38841503
10interkinetic nuclear migration (GO:0022027)4.38645192
11histone H3-K36 demethylation (GO:0070544)4.38032591
12establishment of protein localization to Golgi (GO:0072600)4.22272836
13cytoplasmic mRNA processing body assembly (GO:0033962)4.13177621
14peptidyl-lysine trimethylation (GO:0018023)4.07596319
15B cell receptor signaling pathway (GO:0050853)3.93186303
16lipid translocation (GO:0034204)3.86299178
17phospholipid translocation (GO:0045332)3.86299178
18negative T cell selection (GO:0043383)3.83838148
19protein K48-linked deubiquitination (GO:0071108)3.78423067
20negative thymic T cell selection (GO:0045060)3.70130768
21negative regulation of translation, ncRNA-mediated (GO:0040033)3.64648878
22regulation of translation, ncRNA-mediated (GO:0045974)3.64648878
23negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.64648878
24regulation of establishment of cell polarity (GO:2000114)3.62459976
25positive T cell selection (GO:0043368)3.61732493
26regulation of gamma-delta T cell activation (GO:0046643)3.59358006
27regulation of gamma-delta T cell differentiation (GO:0045586)3.54880233
28protein targeting to Golgi (GO:0000042)3.51544766
29histone mRNA catabolic process (GO:0071044)3.51167805
30retrograde transport, vesicle recycling within Golgi (GO:0000301)3.48179551
31peptidyl-lysine methylation (GO:0018022)3.47775949
32protein K11-linked deubiquitination (GO:0035871)3.47416066
33nuclear pore complex assembly (GO:0051292)3.38727832
34hepatocyte apoptotic process (GO:0097284)3.36738365
35negative regulation of DNA repair (GO:0045738)3.33054985
36regulation of interleukin-12 biosynthetic process (GO:0045075)3.32820756
37histone H3-K4 methylation (GO:0051568)3.31653489
38detection of molecule of bacterial origin (GO:0032490)3.27326135
39regulation of MHC class I biosynthetic process (GO:0045343)3.22649957
40negative regulation of B cell proliferation (GO:0030889)3.16977407
41striated muscle atrophy (GO:0014891)3.13037024
42regulation of establishment or maintenance of cell polarity (GO:0032878)3.10014759
43regulation of histone H3-K27 methylation (GO:0061085)3.03420289
44replicative senescence (GO:0090399)3.03246757
45skeletal muscle adaptation (GO:0043501)2.98890522
46oocyte development (GO:0048599)2.97176822
47regulation of protein polyubiquitination (GO:1902914)2.96906098
48positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.94786141
49protein K63-linked deubiquitination (GO:0070536)2.92524919
50nuclear pore organization (GO:0006999)2.88823709
51positive thymic T cell selection (GO:0045059)2.87242705
52histone lysine methylation (GO:0034968)2.84924982
53histone H3-K9 demethylation (GO:0033169)2.84823396
54histone-serine phosphorylation (GO:0035404)2.83471279
55mature B cell differentiation (GO:0002335)2.80007587
56regulation of granulocyte differentiation (GO:0030852)2.77611740
57protein targeting to lysosome (GO:0006622)2.77577232
58establishment of protein localization to vacuole (GO:0072666)2.77577232
59protein targeting to vacuole (GO:0006623)2.77577232
60nucleus localization (GO:0051647)2.77278112
61microglial cell activation (GO:0001774)2.76244386
62histone lysine demethylation (GO:0070076)2.75395190
63protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.75285825
64T cell selection (GO:0045058)2.74944747
65negative regulation of T cell mediated immunity (GO:0002710)2.74452874
66histone H3-K9 modification (GO:0061647)2.73113257
67regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.73056147
68histone demethylation (GO:0016577)2.70025607
69regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.69515403
70Golgi to endosome transport (GO:0006895)2.67569668
71antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.67028629
72corticosteroid receptor signaling pathway (GO:0031958)2.65527095
73pericardium development (GO:0060039)2.65325954
74definitive hemopoiesis (GO:0060216)2.64535664
75regulation of necroptotic process (GO:0060544)2.63931634
76cellular extravasation (GO:0045123)2.62857629
77cerebellar Purkinje cell differentiation (GO:0021702)2.62084831
78B cell homeostasis (GO:0001782)2.60814739
79B cell proliferation (GO:0042100)2.60607585
80regulation of alpha-beta T cell proliferation (GO:0046640)2.60250806
81histone H3-K9 methylation (GO:0051567)2.59095242
82pre-miRNA processing (GO:0031054)2.58790215
83muscle atrophy (GO:0014889)2.58208719
84negative regulation of myotube differentiation (GO:0010832)2.56428886
85T-helper cell differentiation (GO:0042093)2.54412093
86CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.54412093
87N-terminal protein amino acid acetylation (GO:0006474)2.54090238
88regulation of B cell proliferation (GO:0030888)2.53640241
89positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.53629473
90negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.50940366
91negative regulation of cell killing (GO:0031342)2.50940366
92T cell migration (GO:0072678)2.50653786
93snRNA transcription (GO:0009301)2.47239216
94embryonic hemopoiesis (GO:0035162)2.45818573
95dosage compensation (GO:0007549)2.45549639
96pore complex assembly (GO:0046931)2.44807587
97positive regulation of protein import into nucleus, translocation (GO:0033160)2.44226726
98phosphatidylinositol phosphorylation (GO:0046854)2.43822507
99CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.42027444
100iron ion import (GO:0097286)2.41263508

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.16107767
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.58558590
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.57956392
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.42518610
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.27041454
6SMAD_19615063_ChIP-ChIP_OVARY_Human3.11448802
7CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.82050084
8GATA1_22025678_ChIP-Seq_K562_Human2.63226634
9RUNX_20019798_ChIP-Seq_JUKART_Human2.29066061
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.11013729
11SCL_19346495_ChIP-Seq_HPC-7_Human2.09485310
12SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.08857939
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.01119933
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.00239456
15TP53_16413492_ChIP-PET_HCT116_Human1.96662484
16AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.93480129
17CDX2_19796622_ChIP-Seq_MESCs_Mouse1.89161818
18FLI1_27457419_Chip-Seq_LIVER_Mouse1.87914127
19ZNF217_24962896_ChIP-Seq_MCF-7_Human1.85034907
20VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.81909607
21POU3F2_20337985_ChIP-ChIP_501MEL_Human1.80860937
22AR_21572438_ChIP-Seq_LNCaP_Human1.75066102
23Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.65652734
24GBX2_23144817_ChIP-Seq_PC3_Human1.65072258
25RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.62568931
26PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.61802949
27AHR_22903824_ChIP-Seq_MCF-7_Human1.61314262
28FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.61187997
29STAT3_23295773_ChIP-Seq_U87_Human1.60697710
30TAF15_26573619_Chip-Seq_HEK293_Human1.54020666
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.53517734
32MYB_26560356_Chip-Seq_TH2_Human1.50359199
33TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.49257854
34PCGF2_27294783_Chip-Seq_NPCs_Mouse1.46985485
35VDR_24787735_ChIP-Seq_THP-1_Human1.45889309
36IRF8_27001747_Chip-Seq_BMDM_Mouse1.45589188
37IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.42553330
38ESR1_20079471_ChIP-ChIP_T-47D_Human1.40761484
39ER_23166858_ChIP-Seq_MCF-7_Human1.40352987
40GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.38993283
41ARNT_22903824_ChIP-Seq_MCF-7_Human1.38396676
42CTNNB1_20460455_ChIP-Seq_HCT116_Human1.37037396
43SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.36819779
44TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36773879
45POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.36773879
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.34416014
47FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.34243668
48SMAD4_21799915_ChIP-Seq_A2780_Human1.33313273
49TCF4_23295773_ChIP-Seq_U87_Human1.32985138
50GATA3_27048872_Chip-Seq_THYMUS_Human1.32628845
51ZFP57_27257070_Chip-Seq_ESCs_Mouse1.32586305
52NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.31013685
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.28950136
54SUZ12_27294783_Chip-Seq_NPCs_Mouse1.28709254
55CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.27344488
56MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.27312596
57ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.26222246
58MYB_21317192_ChIP-Seq_ERMYB_Mouse1.25743646
59MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.24820890
60PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23590957
61MYB_26560356_Chip-Seq_TH1_Human1.23522479
62EZH2_27294783_Chip-Seq_NPCs_Mouse1.22910415
63CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.19874846
64STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.19499143
65FOXM1_26456572_ChIP-Seq_MCF-7_Human1.19212945
66IRF8_21731497_ChIP-ChIP_J774_Mouse1.17836872
67RXR_22108803_ChIP-Seq_LS180_Human1.17678159
68BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.17373749
69GATA2_21666600_ChIP-Seq_HMVEC_Human1.17064530
70PRDM14_20953172_ChIP-Seq_ESCs_Human1.16846978
71NOTCH1_21737748_ChIP-Seq_TLL_Human1.16290872
72CBP_20019798_ChIP-Seq_JUKART_Human1.15500272
73IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.15500272
74TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14646687
75RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.14440738
76GATA3_26560356_Chip-Seq_TH2_Human1.13702157
77FUS_26573619_Chip-Seq_HEK293_Human1.13498689
78BCAT_22108803_ChIP-Seq_LS180_Human1.13195926
79NFE2_27457419_Chip-Seq_LIVER_Mouse1.11967154
80FLI1_21867929_ChIP-Seq_TH2_Mouse1.11070073
81GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10164072
82IGF1R_20145208_ChIP-Seq_DFB_Human1.09474748
83ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08116591
84P300_19829295_ChIP-Seq_ESCs_Human1.07160261
85FOXO3_23340844_ChIP-Seq_DLD1_Human1.07155522
86NANOG_18555785_Chip-Seq_ESCs_Mouse1.06353347
87NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06120946
88FOXA2_19822575_ChIP-Seq_HepG2_Human1.05170154
89E2F1_18555785_Chip-Seq_ESCs_Mouse1.04486807
90NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.03697220
91UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02958520
92NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.01914645
93IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.01851426
94OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01777764
95EWS_26573619_Chip-Seq_HEK293_Human1.01420501
96OCT4_21477851_ChIP-Seq_ESCs_Mouse1.01230787
97VDR_22108803_ChIP-Seq_LS180_Human1.00915001
98NRF2_20460467_ChIP-Seq_MEFs_Mouse1.00816853
99NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.00816853
100CDX2_22108803_ChIP-Seq_LS180_Human1.00047563

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation6.42778193
2MP0008057_abnormal_DNA_replication5.90043483
3MP0003763_abnormal_thymus_physiology3.58231909
4MP0004381_abnormal_hair_follicle3.16069484
5MP0003045_fibrosis2.95990404
6MP0002009_preneoplasia2.94481046
7MP0001835_abnormal_antigen_presentation2.62400623
8MP0002166_altered_tumor_susceptibility2.34620818
9MP0001800_abnormal_humoral_immune2.11537976
10MP0002396_abnormal_hematopoietic_system2.08497457
11MP0000383_abnormal_hair_follicle2.08377662
12MP0005075_abnormal_melanosome_morpholog1.98623518
13MP0000015_abnormal_ear_pigmentation1.96304386
14MP0000685_abnormal_immune_system1.93519290
15MP0005310_abnormal_salivary_gland1.90679902
16MP0005174_abnormal_tail_pigmentation1.88762035
17MP0003950_abnormal_plasma_membrane1.67689932
18MP0000371_diluted_coat_color1.63481822
19MP0010352_gastrointestinal_tract_polyps1.58894486
20MP0010678_abnormal_skin_adnexa1.58406035
21MP0002168_other_aberrant_phenotype1.57947706
22MP0003646_muscle_fatigue1.57478560
23MP0010307_abnormal_tumor_latency1.55655859
24MP0005076_abnormal_cell_differentiation1.52287655
25MP0003300_gastrointestinal_ulcer1.50983399
26MP0004808_abnormal_hematopoietic_stem1.50980271
27MP0003656_abnormal_erythrocyte_physiolo1.50527123
28MP0003828_pulmonary_edema1.50109125
29MP0002006_tumorigenesis1.49635569
30MP0002398_abnormal_bone_marrow1.49606207
31MP0003091_abnormal_cell_migration1.48994279
32MP0003866_abnormal_defecation1.45504213
33MP0002452_abnormal_antigen_presenting1.44073827
34MP0002420_abnormal_adaptive_immunity1.43445908
35MP0000703_abnormal_thymus_morphology1.43302399
36MP0000372_irregular_coat_pigmentation1.41440973
37MP0001819_abnormal_immune_cell1.39673603
38MP0002723_abnormal_immune_serum1.36862064
39MP0000427_abnormal_hair_cycle1.33833103
40MP0002405_respiratory_system_inflammati1.33490554
41MP0003724_increased_susceptibility_to1.33106200
42MP0002332_abnormal_exercise_endurance1.32662519
43MP0005671_abnormal_response_to1.31879263
44MP0001790_abnormal_immune_system1.30396090
45MP0005387_immune_system_phenotype1.30396090
46MP0003787_abnormal_imprinting1.29692077
47MP0000716_abnormal_immune_system1.26887444
48MP0008961_abnormal_basal_metabolism1.26373521
49MP0000689_abnormal_spleen_morphology1.25928618
50MP0005408_hypopigmentation1.25500299
51MP0004883_abnormal_blood_vessel1.21477402
52MP0002722_abnormal_immune_system1.19898360
53MP0005397_hematopoietic_system_phenotyp1.19721416
54MP0001545_abnormal_hematopoietic_system1.19721416
55MP0002419_abnormal_innate_immunity1.19236811
56MP0004130_abnormal_muscle_cell1.16954190
57MP0005000_abnormal_immune_tolerance1.13652685
58MP0003890_abnormal_embryonic-extraembry1.12234138
59MP0004484_altered_response_of1.09153553
60MP0008260_abnormal_autophagy1.08681416
61MP0001851_eye_inflammation1.02772838
62MP0008877_abnormal_DNA_methylation1.00979480
63MP0009115_abnormal_fat_cell0.99439043
64MP0004947_skin_inflammation0.98730611
65MP0005409_darkened_coat_color0.95256821
66MP0004264_abnormal_extraembryonic_tissu0.93941169
67MP0002429_abnormal_blood_cell0.93389345
68MP0003195_calcinosis0.91444421
69MP0004084_abnormal_cardiac_muscle0.89807796
70MP0002928_abnormal_bile_duct0.88971406
71MP0005266_abnormal_metabolism0.87733312
72MP0010155_abnormal_intestine_physiology0.87431740
73MP0000465_gastrointestinal_hemorrhage0.87176501
74MP0005621_abnormal_cell_physiology0.86816305
75MP0003868_abnormal_feces_composition0.86409555
76MP0001879_abnormal_lymphatic_vessel0.85652595
77MP0001873_stomach_inflammation0.85181413
78MP0005025_abnormal_response_to0.84576712
79MP0003632_abnormal_nervous_system0.84369393
80MP0003172_abnormal_lysosome_physiology0.84363861
81MP0005167_abnormal_blood-brain_barrier0.82428597
82MP0004036_abnormal_muscle_relaxation0.80137481
83MP0003221_abnormal_cardiomyocyte_apopto0.79481439
84MP0002095_abnormal_skin_pigmentation0.78965728
85MP0000249_abnormal_blood_vessel0.77527669
86MP0004145_abnormal_muscle_electrophysio0.77301135
87MP0005164_abnormal_response_to0.76919868
88MP0002998_abnormal_bone_remodeling0.74528013
89MP0008995_early_reproductive_senescence0.74424799
90MP0006054_spinal_hemorrhage0.74209075
91MP0003690_abnormal_glial_cell0.72531069
92MP0002075_abnormal_coat/hair_pigmentati0.71293064
93MP0002933_joint_inflammation0.70875070
94MP0003436_decreased_susceptibility_to0.69332514
95MP0002019_abnormal_tumor_incidence0.66654290
96MP0005464_abnormal_platelet_physiology0.64476778
97MP0009278_abnormal_bone_marrow0.64325210
98MP0001845_abnormal_inflammatory_respons0.63681472
99MP0009785_altered_susceptibility_to0.63213273
100MP0002138_abnormal_hepatobiliary_system0.62775506

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)4.28134905
2T lymphocytopenia (HP:0005403)4.26201718
3Abnormality of T cell number (HP:0011839)4.03330022
4Colitis (HP:0002583)3.80187308
5Submucous cleft hard palate (HP:0000176)3.75867523
6Genetic anticipation (HP:0003743)3.41132975
7IgA deficiency (HP:0002720)3.36945315
8Autoimmune hemolytic anemia (HP:0001890)3.32322529
9Gaze-evoked nystagmus (HP:0000640)3.13975842
10Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.12126098
11Abnormal delayed hypersensitivity skin test (HP:0002963)3.10704460
12Fair hair (HP:0002286)3.00067326
13Prominent nose (HP:0000448)2.88207137
14Acute myeloid leukemia (HP:0004808)2.87749506
15IgM deficiency (HP:0002850)2.83160853
16Short chin (HP:0000331)2.82145461
17Chronic mucocutaneous candidiasis (HP:0002728)2.80830602
18Recurrent cutaneous fungal infections (HP:0011370)2.80830602
19Thoracolumbar scoliosis (HP:0002944)2.75842729
20Thyroiditis (HP:0100646)2.65200889
21Widely spaced teeth (HP:0000687)2.60142892
22Inflammation of the large intestine (HP:0002037)2.58993587
23Generalized hypopigmentation of hair (HP:0011358)2.58009400
24Protruding tongue (HP:0010808)2.56622086
25Recurrent fungal infections (HP:0002841)2.56179122
26Narrow palate (HP:0000189)2.55909086
27Abnormality of T cells (HP:0002843)2.53036115
28Sandal gap (HP:0001852)2.52892118
29Recurrent viral infections (HP:0004429)2.52788683
30Dysmetric saccades (HP:0000641)2.49481859
31Hypoplasia of the thymus (HP:0000778)2.43725330
32Stomach cancer (HP:0012126)2.41849438
33Truncal obesity (HP:0001956)2.41605053
34Viral hepatitis (HP:0006562)2.41380816
35Subacute progressive viral hepatitis (HP:0006572)2.38500875
36Volvulus (HP:0002580)2.34564452
37Papillary thyroid carcinoma (HP:0002895)2.34358540
38Chin dimple (HP:0010751)2.32503944
39Chronic diarrhea (HP:0002028)2.30677735
40Recurrent bacterial skin infections (HP:0005406)2.23488163
41Optic neuritis (HP:0100653)2.21860901
42Retrobulbar optic neuritis (HP:0100654)2.21860901
43Gastrointestinal inflammation (HP:0004386)2.20406831
44Clumsiness (HP:0002312)2.20114473
45Clubbing of toes (HP:0100760)2.19758704
46Panhypogammaglobulinemia (HP:0003139)2.19690845
47Hyperventilation (HP:0002883)2.17944134
48Recurrent bronchitis (HP:0002837)2.16498070
49Progressive cerebellar ataxia (HP:0002073)2.14303000
50Hyperkalemia (HP:0002153)2.13628108
51Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.11999276
52Conjunctival telangiectasia (HP:0000524)2.10683098
53Tented upper lip vermilion (HP:0010804)2.09919366
54Heterotopia (HP:0002282)2.07093170
55Neonatal hypoglycemia (HP:0001998)2.07090920
56Febrile seizures (HP:0002373)2.06117605
57Abnormality of chromosome stability (HP:0003220)2.03711032
58Abnormality of the nasal septum (HP:0000419)2.02905072
59Mediastinal lymphadenopathy (HP:0100721)2.02881638
60Long eyelashes (HP:0000527)2.02656456
61Chronic hepatic failure (HP:0100626)2.00983030
62Thyroid-stimulating hormone excess (HP:0002925)1.93491288
63Neoplasm of the tracheobronchial system (HP:0100552)1.92933707
64Blue irides (HP:0000635)1.92431380
65Abnormality of the vasculature of the conjunctiva (HP:0008054)1.90979516
66Tapered finger (HP:0001182)1.89818498
67Recurrent skin infections (HP:0001581)1.89200115
68Autoimmune thrombocytopenia (HP:0001973)1.87215708
69Overlapping toe (HP:0001845)1.86523672
70Overgrowth (HP:0001548)1.86052933
71Abnormal glucose tolerance (HP:0001952)1.83599791
72Abnormality of the columella (HP:0009929)1.83482247
73Low anterior hairline (HP:0000294)1.82812071
74Acute lymphatic leukemia (HP:0006721)1.82349719
75Hematochezia (HP:0002573)1.82329115
76Orchitis (HP:0100796)1.81714463
77Spontaneous hematomas (HP:0007420)1.79888672
78Abnormality of the axillary hair (HP:0100134)1.79394245
79Abnormality of secondary sexual hair (HP:0009888)1.79394245
80Chromsome breakage (HP:0040012)1.79301413
81Abnormality of incisor morphology (HP:0011063)1.78983653
82Gingivitis (HP:0000230)1.78634360
83Myositis (HP:0100614)1.77435816
84Slow saccadic eye movements (HP:0000514)1.76922733
85Chromosomal breakage induced by crosslinking agents (HP:0003221)1.76713145
86Thick eyebrow (HP:0000574)1.76144383
87Eosinophilia (HP:0001880)1.75551444
88Keratoconjunctivitis sicca (HP:0001097)1.74404588
89Facial diplegia (HP:0001349)1.72900090
90Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.72668774
91Dislocated radial head (HP:0003083)1.71493986
92Eczematoid dermatitis (HP:0000976)1.70695295
93Abnormality of T cell physiology (HP:0011840)1.69859535
94Macroorchidism (HP:0000053)1.68770102
95Abnormality of eosinophils (HP:0001879)1.68665498
96Arterial thrombosis (HP:0004420)1.68195675
97Portal hypertension (HP:0001409)1.67206766
98IgG deficiency (HP:0004315)1.66916167
99Abnormality of the epiphyses of the hand (HP:0005924)1.65526684
100Hypoplastic iliac wings (HP:0002866)1.65263878

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.23829565
2TAOK32.83918430
3CDK122.83683117
4AKT32.54291000
5BLK2.42642484
6ACVR1B2.27946738
7TRPM72.22723282
8SGK22.13191959
9NLK2.07620244
10BMPR1B1.91336538
11BRD41.85853012
12CAMK1D1.83332885
13TEC1.80646975
14MELK1.76487054
15WNK11.71326787
16CAMK1G1.65720203
17JAK11.57234206
18FGFR31.55503684
19TXK1.54832692
20PIK3CG1.51970189
21BTK1.42720324
22SGK31.40056929
23OBSCN1.37520459
24IKBKE1.37193111
25MAP3K71.31023466
26BMPR21.28368332
27SGK2231.22162904
28SGK4941.22162904
29SYK1.18454940
30ITK1.14818300
31MAP4K11.14124236
32MAP3K141.10863486
33MAPK111.08478606
34MAP3K21.06214422
35MAP3K131.05431102
36MKNK21.04099884
37MARK21.02009216
38MAPK130.99400624
39PRKAA20.98500252
40PIM10.98195746
41MARK30.98079768
42PIK3CA0.92881489
43RIPK40.92816567
44IRAK10.92379066
45STK38L0.91292069
46HCK0.90785393
47CHUK0.89982336
48SGK10.88831515
49PTK2B0.87390438
50PDGFRB0.83990786
51CDC42BPA0.83870660
52JAK30.81667561
53ZAK0.81264940
54LATS10.80043843
55GRK60.79641262
56EEF2K0.78883211
57MAP2K30.78420877
58EPHA30.78183196
59CAMKK20.77742257
60MAP3K40.75526942
61ZAP700.73665268
62ERBB20.73487420
63CAMK40.72573735
64LCK0.72416319
65FGFR20.71896027
66STK40.71036188
67FES0.69878753
68JAK20.66991939
69IKBKB0.66104750
70MAP3K60.64611327
71TYK20.63918136
72FGR0.62248544
73NEK90.60997902
74MTOR0.60828311
75NEK60.60782617
76CSK0.60694801
77KIT0.59909324
78RET0.58800175
79TGFBR10.57986386
80BRSK20.57845037
81EGFR0.55894801
82PKN20.53946643
83MAP3K100.53434945
84EIF2AK30.52888306
85LYN0.50261273
86NUAK10.49699793
87ADRBK20.49274149
88STK390.48673712
89CDK60.47042288
90PDK10.46652382
91MAPK70.45371939
92FGFR40.44781753
93PRKCQ0.41854058
94STK380.41534362
95ATM0.40901271
96STK30.40352254
97RPS6KB20.39288297
98IRAK40.37113970
99DYRK1A0.37019516
100PRKAA10.36050176

Predicted pathways (KEGG)

RankGene SetZ-score
1B cell receptor signaling pathway_Homo sapiens_hsa046621.93172262
2Dorso-ventral axis formation_Homo sapiens_hsa043201.90078436
3NF-kappa B signaling pathway_Homo sapiens_hsa040641.88596706
4T cell receptor signaling pathway_Homo sapiens_hsa046601.82963667
5Phosphatidylinositol signaling system_Homo sapiens_hsa040701.73537958
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.56052123
7Jak-STAT signaling pathway_Homo sapiens_hsa046301.51268848
8Systemic lupus erythematosus_Homo sapiens_hsa053221.49188921
9Lysine degradation_Homo sapiens_hsa003101.47126818
10ABC transporters_Homo sapiens_hsa020101.46971254
11Non-small cell lung cancer_Homo sapiens_hsa052231.44333018
12NOD-like receptor signaling pathway_Homo sapiens_hsa046211.41351180
13Graft-versus-host disease_Homo sapiens_hsa053321.39519543
14Osteoclast differentiation_Homo sapiens_hsa043801.39141060
15Primary immunodeficiency_Homo sapiens_hsa053401.38514658
16FoxO signaling pathway_Homo sapiens_hsa040681.37867033
17Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.36076523
18TNF signaling pathway_Homo sapiens_hsa046681.35349625
19Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.35037127
20Platelet activation_Homo sapiens_hsa046111.33778392
21Intestinal immune network for IgA production_Homo sapiens_hsa046721.33145513
22Measles_Homo sapiens_hsa051621.32022664
23Inositol phosphate metabolism_Homo sapiens_hsa005621.31782846
24Leishmaniasis_Homo sapiens_hsa051401.24702987
25RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.21818768
26Toxoplasmosis_Homo sapiens_hsa051451.21482500
27Autoimmune thyroid disease_Homo sapiens_hsa053201.19769561
28Acute myeloid leukemia_Homo sapiens_hsa052211.19515581
29MicroRNAs in cancer_Homo sapiens_hsa052061.18972830
30Prostate cancer_Homo sapiens_hsa052151.16854671
31Allograft rejection_Homo sapiens_hsa053301.16527207
32Circadian rhythm_Homo sapiens_hsa047101.14006478
33AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.11851522
34Hepatitis B_Homo sapiens_hsa051611.08713661
35Prolactin signaling pathway_Homo sapiens_hsa049171.08712245
36Influenza A_Homo sapiens_hsa051641.07905566
37Transcriptional misregulation in cancer_Homo sapiens_hsa052021.06385968
38Pancreatic cancer_Homo sapiens_hsa052121.05366749
39Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.03744825
40Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.03630311
41mTOR signaling pathway_Homo sapiens_hsa041501.03536825
42Toll-like receptor signaling pathway_Homo sapiens_hsa046201.02472317
43Type II diabetes mellitus_Homo sapiens_hsa049301.01583869
44Hematopoietic cell lineage_Homo sapiens_hsa046401.00824746
45Colorectal cancer_Homo sapiens_hsa052100.99505919
46Tuberculosis_Homo sapiens_hsa051520.97819928
47Choline metabolism in cancer_Homo sapiens_hsa052310.96393670
48Endometrial cancer_Homo sapiens_hsa052130.96380394
49Insulin resistance_Homo sapiens_hsa049310.96188391
50Apoptosis_Homo sapiens_hsa042100.95884861
51Staphylococcus aureus infection_Homo sapiens_hsa051500.94636788
52Chronic myeloid leukemia_Homo sapiens_hsa052200.94171852
53Longevity regulating pathway - mammal_Homo sapiens_hsa042110.91466248
54Small cell lung cancer_Homo sapiens_hsa052220.90666785
55Viral carcinogenesis_Homo sapiens_hsa052030.87393119
56Thyroid hormone signaling pathway_Homo sapiens_hsa049190.86951616
57Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.86835353
58ErbB signaling pathway_Homo sapiens_hsa040120.86663877
59Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.86237351
60Vascular smooth muscle contraction_Homo sapiens_hsa042700.85783344
61GnRH signaling pathway_Homo sapiens_hsa049120.84448894
62Renal cell carcinoma_Homo sapiens_hsa052110.83826719
63Glioma_Homo sapiens_hsa052140.82658382
64Neurotrophin signaling pathway_Homo sapiens_hsa047220.82556037
65Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.77973162
66Fanconi anemia pathway_Homo sapiens_hsa034600.77915827
67Type I diabetes mellitus_Homo sapiens_hsa049400.77008298
68Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.76331470
69Herpes simplex infection_Homo sapiens_hsa051680.76285629
70Phospholipase D signaling pathway_Homo sapiens_hsa040720.74736450
71Hepatitis C_Homo sapiens_hsa051600.74446321
72MAPK signaling pathway_Homo sapiens_hsa040100.73245146
73Asthma_Homo sapiens_hsa053100.72535189
74Adherens junction_Homo sapiens_hsa045200.72163147
75Taste transduction_Homo sapiens_hsa047420.72051547
76HIF-1 signaling pathway_Homo sapiens_hsa040660.71559694
77Chemokine signaling pathway_Homo sapiens_hsa040620.70906582
78Malaria_Homo sapiens_hsa051440.68802966
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.68668744
80Estrogen signaling pathway_Homo sapiens_hsa049150.68511670
81Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.67084191
82Alcoholism_Homo sapiens_hsa050340.66038484
83Aldosterone synthesis and secretion_Homo sapiens_hsa049250.65410946
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65263469
85Leukocyte transendothelial migration_Homo sapiens_hsa046700.64594304
86Long-term potentiation_Homo sapiens_hsa047200.63989201
87Renin secretion_Homo sapiens_hsa049240.63835190
88Cholinergic synapse_Homo sapiens_hsa047250.62257569
89Calcium signaling pathway_Homo sapiens_hsa040200.61639299
90Oxytocin signaling pathway_Homo sapiens_hsa049210.61120409
91VEGF signaling pathway_Homo sapiens_hsa043700.60536537
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.59826575
93cGMP-PKG signaling pathway_Homo sapiens_hsa040220.57522141
94Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54497274
95Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.53045558
96Ovarian steroidogenesis_Homo sapiens_hsa049130.51797727
97HTLV-I infection_Homo sapiens_hsa051660.51705085
98Antigen processing and presentation_Homo sapiens_hsa046120.50493030
99Long-term depression_Homo sapiens_hsa047300.49696828
100Focal adhesion_Homo sapiens_hsa045100.49410209

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