SMG1P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.14703959
2regulation of B cell receptor signaling pathway (GO:0050855)4.36032850
3regulation of gamma-delta T cell differentiation (GO:0045586)4.32387554
4negative regulation of cell killing (GO:0031342)4.28896570
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.28896570
6nuclear pore complex assembly (GO:0051292)4.28864754
7regulation of gamma-delta T cell activation (GO:0046643)4.14439882
8positive regulation of interleukin-17 production (GO:0032740)4.11503342
9positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.90634754
10response to interleukin-15 (GO:0070672)3.83011601
11positive regulation of granulocyte differentiation (GO:0030854)3.81469735
12negative T cell selection (GO:0043383)3.72149087
13negative thymic T cell selection (GO:0045060)3.68839814
14cellular response to interleukin-15 (GO:0071350)3.67635851
15positive regulation of B cell differentiation (GO:0045579)3.59564979
16histone H3-K36 demethylation (GO:0070544)3.58978100
17regulation of B cell differentiation (GO:0045577)3.54759435
18nuclear pore organization (GO:0006999)3.54594901
19negative regulation of T cell mediated immunity (GO:0002710)3.53633438
20monoubiquitinated protein deubiquitination (GO:0035520)3.51165985
21hepatocyte apoptotic process (GO:0097284)3.50904124
22positive regulation of natural killer cell differentiation (GO:0032825)3.39260168
23B cell receptor signaling pathway (GO:0050853)3.38258834
24positive T cell selection (GO:0043368)3.37095375
25pore complex assembly (GO:0046931)3.34734621
26positive regulation of alpha-beta T cell proliferation (GO:0046641)3.28587544
27regulation of interleukin-12 biosynthetic process (GO:0045075)3.26340112
28negative regulation of T-helper cell differentiation (GO:0045623)3.23974554
29negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.23974554
30antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.15717590
31dosage compensation (GO:0007549)3.15107357
32regulation of isotype switching to IgG isotypes (GO:0048302)3.14406510
33T cell migration (GO:0072678)3.13667059
34positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.12735967
35regulation of alpha-beta T cell proliferation (GO:0046640)3.11931545
36positive regulation of natural killer cell mediated immunity (GO:0002717)3.10728195
37negative regulation of adaptive immune response (GO:0002820)3.09865113
38phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.09780091
39cellular extravasation (GO:0045123)3.09280538
40negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.08911670
41negative regulation of lymphocyte mediated immunity (GO:0002707)3.07625664
42histone mRNA catabolic process (GO:0071044)3.07441016
43definitive hemopoiesis (GO:0060216)3.03508839
44positive thymic T cell selection (GO:0045059)3.01501084
45peptidyl-lysine trimethylation (GO:0018023)2.98749789
46regulation of regulatory T cell differentiation (GO:0045589)2.96942657
47positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.96333068
48regulation of interleukin-17 production (GO:0032660)2.96254474
49tolerance induction (GO:0002507)2.93951647
50regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.93511790
51regulation of natural killer cell mediated immunity (GO:0002715)2.93511790
52negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.91135238
53neutrophil activation involved in immune response (GO:0002283)2.86099404
54regulation of B cell proliferation (GO:0030888)2.85343225
55necroptotic process (GO:0070266)2.83726426
56histone H3-K4 trimethylation (GO:0080182)2.83645924
57T cell selection (GO:0045058)2.83412756
58positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.81613920
59regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.81377177
60antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.79107993
61interferon-gamma production (GO:0032609)2.75188226
62embryonic process involved in female pregnancy (GO:0060136)2.74036794
63positive regulation of B cell proliferation (GO:0030890)2.71453143
64regulation of isotype switching (GO:0045191)2.71302368
65necrotic cell death (GO:0070265)2.71280986
66negative regulation of B cell proliferation (GO:0030889)2.70387124
67positive regulation of isotype switching (GO:0045830)2.68485635
68histone demethylation (GO:0016577)2.68429064
69activated T cell proliferation (GO:0050798)2.68201637
70leukocyte aggregation (GO:0070486)2.68180605
71T-helper cell differentiation (GO:0042093)2.67494937
72CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.67494937
73regulation of B cell activation (GO:0050864)2.66205885
74neutrophil mediated immunity (GO:0002446)2.63219538
75regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.61771992
76cellular response to ethanol (GO:0071361)2.61690584
77antigen receptor-mediated signaling pathway (GO:0050851)2.60264781
78B cell homeostasis (GO:0001782)2.60103645
79thymic T cell selection (GO:0045061)2.59987373
80regulation of MHC class II biosynthetic process (GO:0045346)2.59379155
81positive regulation of interleukin-2 production (GO:0032743)2.58769772
82response to muramyl dipeptide (GO:0032495)2.58490600
83negative regulation of B cell activation (GO:0050869)2.58398442
84histone lysine demethylation (GO:0070076)2.57630658
85positive regulation of B cell activation (GO:0050871)2.57499835
86protein K11-linked deubiquitination (GO:0035871)2.56803685
87production of molecular mediator of immune response (GO:0002440)2.56397697
88negative regulation of interleukin-12 production (GO:0032695)2.56024631
89mast cell activation (GO:0045576)2.55611411
90programmed necrotic cell death (GO:0097300)2.54652370
91neutrophil activation (GO:0042119)2.53825925
92regulation of histone H3-K9 methylation (GO:0051570)2.53411419
93regulation of RNA export from nucleus (GO:0046831)2.52690290
94regulation of granulocyte differentiation (GO:0030852)2.51828414
95antigen processing and presentation of endogenous antigen (GO:0019883)2.51502780
96B cell proliferation (GO:0042100)2.51040605
97mucosal-associated lymphoid tissue development (GO:0048537)2.49994693
98Peyers patch development (GO:0048541)2.49994693
99T cell homeostasis (GO:0043029)2.48768276
100antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.48403842

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.45991056
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.43205421
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.07119012
4E2F7_22180533_ChIP-Seq_HELA_Human3.31151121
5STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.19835085
6EGR1_19374776_ChIP-ChIP_THP-1_Human2.92117479
7NOTCH1_21737748_ChIP-Seq_TLL_Human2.85418458
8MYB_26560356_Chip-Seq_TH2_Human2.83057322
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.80904538
10RUNX_20019798_ChIP-Seq_JUKART_Human2.76632035
11BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.76521604
12GATA1_22025678_ChIP-Seq_K562_Human2.75790671
13SCL_19346495_ChIP-Seq_HPC-7_Human2.63869139
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.47898086
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.42544067
16MYB_26560356_Chip-Seq_TH1_Human2.41959814
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.41553179
18BP1_19119308_ChIP-ChIP_Hs578T_Human2.34816950
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.34537825
20FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.32754798
21SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.32651883
22SMAD_19615063_ChIP-ChIP_OVARY_Human2.31545097
23IRF8_21731497_ChIP-ChIP_J774_Mouse2.28265078
24NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.26565573
25IRF8_27001747_Chip-Seq_BMDM_Mouse2.14633170
26NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.02444931
27STAT4_19710469_ChIP-ChIP_TH1__Mouse2.00930602
28SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.97043660
29GATA3_27048872_Chip-Seq_THYMUS_Human1.95775304
30E2F4_17652178_ChIP-ChIP_JURKAT_Human1.92776909
31SPI1_23547873_ChIP-Seq_NB4_Human1.92370888
32Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.88678863
33SALL1_21062744_ChIP-ChIP_HESCs_Human1.74954198
34IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.73346506
35MYC_22102868_ChIP-Seq_BL_Human1.72996555
36MAF_26560356_Chip-Seq_TH1_Human1.66724070
37RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.65643800
38STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.64623190
39GATA3_26560356_Chip-Seq_TH2_Human1.62020010
40ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.57023136
41KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.48956756
42VDR_23849224_ChIP-Seq_CD4+_Human1.46030431
43SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.42497044
44BRD4_27068464_Chip-Seq_AML-cells_Mouse1.41915231
45FOXM1_23109430_ChIP-Seq_U2OS_Human1.40460675
46CIITA_25753668_ChIP-Seq_RAJI_Human1.36627028
47VDR_24787735_ChIP-Seq_THP-1_Human1.34455083
48HOXB4_20404135_ChIP-ChIP_EML_Mouse1.27529791
49PU_27001747_Chip-Seq_BMDM_Mouse1.25856135
50PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.25462476
51UTX_26944678_Chip-Seq_JUKART_Human1.24790586
52TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.24222954
53RUNX1_22412390_ChIP-Seq_EML_Mouse1.22356244
54PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19974347
55CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.16922778
56NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.16415043
57SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.16192919
58VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.14871156
59SPI1_23127762_ChIP-Seq_K562_Human1.14484748
60PADI4_21655091_ChIP-ChIP_MCF-7_Human1.14470541
61VDR_24763502_ChIP-Seq_THP-1_Human1.14324453
62E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.14235673
63POU3F2_20337985_ChIP-ChIP_501MEL_Human1.13798546
64TCF7_22412390_ChIP-Seq_EML_Mouse1.09184141
65ELK1_19687146_ChIP-ChIP_HELA_Human1.08992205
66TFEB_21752829_ChIP-Seq_HELA_Human1.08437847
67KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.06845407
68GATA2_22383799_ChIP-Seq_G1ME_Mouse1.06546185
69PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05869914
70GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05365709
71TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.03381348
72FOXP3_21729870_ChIP-Seq_TREG_Human1.03306021
73MAF_26560356_Chip-Seq_TH2_Human1.02088937
74ELF1_17652178_ChIP-ChIP_JURKAT_Human0.99867918
75FLI1_27457419_Chip-Seq_LIVER_Mouse0.99647812
76TAF15_26573619_Chip-Seq_HEK293_Human0.98417950
77PKCTHETA_26484144_Chip-Seq_BREAST_Human0.97788085
78RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.97591027
79GATA2_19941826_ChIP-Seq_K562_Human0.97582654
80GATA2_21666600_ChIP-Seq_HMVEC_Human0.96501688
81GATA1_19941826_ChIP-Seq_K562_Human0.92485915
82RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.89080156
83GATA3_26560356_Chip-Seq_TH1_Human0.88132445
84FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.86912146
85GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.84403166
86FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.83614314
87E2F1_21310950_ChIP-Seq_MCF-7_Human0.83363947
88MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.83252978
89TP53_16413492_ChIP-PET_HCT116_Human0.81551319
90SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.81545126
91SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.81545126
92SALL4_22934838_ChIP-ChIP_CD34+_Human0.81247603
93ER_23166858_ChIP-Seq_MCF-7_Human0.81110699
94SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80806642
95GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79975841
96FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.78931833
97ETS1_22383799_ChIP-Seq_G1ME_Mouse0.78773457
98CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.78288097
99FOXO3_23340844_ChIP-Seq_DLD1_Human0.76971167
100GATA1_19941827_ChIP-Seq_MEL_Mouse0.76783288

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.28330996
2MP0003763_abnormal_thymus_physiology3.63472762
3MP0001835_abnormal_antigen_presentation3.63270132
4MP0001800_abnormal_humoral_immune2.65610638
5MP0003724_increased_susceptibility_to2.56904404
6MP0000569_abnormal_digit_pigmentation2.56327312
7MP0005671_abnormal_response_to2.51221906
8MP0002396_abnormal_hematopoietic_system2.45907113
9MP0002009_preneoplasia2.34168578
10MP0005000_abnormal_immune_tolerance2.29256749
11MP0002398_abnormal_bone_marrow2.26555443
12MP0003436_decreased_susceptibility_to2.23349279
13MP0002420_abnormal_adaptive_immunity2.16434110
14MP0002723_abnormal_immune_serum2.13968552
15MP0001819_abnormal_immune_cell2.09505632
16MP0002452_abnormal_antigen_presenting2.09131783
17MP0002166_altered_tumor_susceptibility2.06383084
18MP0000465_gastrointestinal_hemorrhage2.05075471
19MP0000689_abnormal_spleen_morphology1.97160106
20MP0003656_abnormal_erythrocyte_physiolo1.96581804
21MP0000703_abnormal_thymus_morphology1.94376119
22MP0002405_respiratory_system_inflammati1.93577317
23MP0000685_abnormal_immune_system1.90636127
24MP0002419_abnormal_innate_immunity1.89263812
25MP0002722_abnormal_immune_system1.88301364
26MP0005464_abnormal_platelet_physiology1.84416338
27MP0000716_abnormal_immune_system1.84398440
28MP0004808_abnormal_hematopoietic_stem1.82378056
29MP0003303_peritoneal_inflammation1.79558388
30MP0009785_altered_susceptibility_to1.79431973
31MP0001790_abnormal_immune_system1.79368792
32MP0005387_immune_system_phenotype1.79368792
33MP0003300_gastrointestinal_ulcer1.78594757
34MP0003828_pulmonary_edema1.76678663
35MP0005025_abnormal_response_to1.75270868
36MP0004381_abnormal_hair_follicle1.73617926
37MP0008260_abnormal_autophagy1.73207498
38MP0010094_abnormal_chromosome_stability1.58722975
39MP0002429_abnormal_blood_cell1.57778994
40MP0003221_abnormal_cardiomyocyte_apopto1.54533343
41MP0005451_abnormal_body_composition1.52512730
42MP0001873_stomach_inflammation1.51355979
43MP0002006_tumorigenesis1.49537536
44MP0010155_abnormal_intestine_physiology1.48267015
45MP0002148_abnormal_hypersensitivity_rea1.47940963
46MP0001853_heart_inflammation1.47706847
47MP0009333_abnormal_splenocyte_physiolog1.46921641
48MP0005310_abnormal_salivary_gland1.39088460
49MP0008058_abnormal_DNA_repair1.38067228
50MP0001851_eye_inflammation1.37442828
51MP0003111_abnormal_nucleus_morphology1.36701736
52MP0003077_abnormal_cell_cycle1.35836483
53MP0004947_skin_inflammation1.35226438
54MP0001545_abnormal_hematopoietic_system1.29815736
55MP0005397_hematopoietic_system_phenotyp1.29815736
56MP0008007_abnormal_cellular_replicative1.29661361
57MP0001845_abnormal_inflammatory_respons1.26019879
58MP0003866_abnormal_defecation1.24731104
59MP0000015_abnormal_ear_pigmentation1.23387845
60MP0005075_abnormal_melanosome_morpholog1.22385691
61MP0010352_gastrointestinal_tract_polyps1.21098009
62MP0010307_abnormal_tumor_latency1.20156204
63MP0005076_abnormal_cell_differentiation1.19584426
64MP0002019_abnormal_tumor_incidence1.17079569
65MP0008877_abnormal_DNA_methylation1.14612554
66MP0003786_premature_aging1.11181260
67MP0003787_abnormal_imprinting1.04833544
68MP0009764_decreased_sensitivity_to1.02317846
69MP0004957_abnormal_blastocyst_morpholog1.01349829
70MP0004264_abnormal_extraembryonic_tissu1.00868048
71MP0006082_CNS_inflammation0.98131223
72MP0003172_abnormal_lysosome_physiology0.94042050
73MP0008995_early_reproductive_senescence0.87380742
74MP0000858_altered_metastatic_potential0.87378232
75MP0005621_abnormal_cell_physiology0.86589277
76MP0004484_altered_response_of0.84478278
77MP0008004_abnormal_stomach_pH0.84416829
78MP0000350_abnormal_cell_proliferation0.83042336
79MP0001191_abnormal_skin_condition0.82546290
80MP0000313_abnormal_cell_death0.82288627
81MP0002138_abnormal_hepatobiliary_system0.78131885
82MP0002086_abnormal_extraembryonic_tissu0.77655823
83MP0003943_abnormal_hepatobiliary_system0.74880823
84MP0003984_embryonic_growth_retardation0.74721686
85MP0008469_abnormal_protein_level0.73648578
86MP0002088_abnormal_embryonic_growth/wei0.73038097
87MP0009278_abnormal_bone_marrow0.71230815
88MP0008961_abnormal_basal_metabolism0.70765913
89MP0003091_abnormal_cell_migration0.70160736
90MP0009763_increased_sensitivity_to0.69666299
91MP0003693_abnormal_embryo_hatching0.69250754
92MP0004883_abnormal_blood_vessel0.67338149
93MP0001672_abnormal_embryogenesis/_devel0.67148902
94MP0005380_embryogenesis_phenotype0.67148902
95MP0002132_abnormal_respiratory_system0.66710110
96MP0000371_diluted_coat_color0.65293541
97MP0009765_abnormal_xenobiotic_induced0.65153012
98MP0005384_cellular_phenotype0.63886553
99MP0002332_abnormal_exercise_endurance0.63187537
100MP0003045_fibrosis0.62725269

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)5.69012294
2Abnormality of T cell number (HP:0011839)5.25040901
3Stomatitis (HP:0010280)3.85056019
4Abnormality of T cells (HP:0002843)3.77198200
5Autoimmune hemolytic anemia (HP:0001890)3.65534895
6Chronic diarrhea (HP:0002028)3.52141068
7Abnormal delayed hypersensitivity skin test (HP:0002963)3.48881804
8Recurrent viral infections (HP:0004429)3.46941937
9Inflammation of the large intestine (HP:0002037)3.35852774
10Severe combined immunodeficiency (HP:0004430)3.35263657
11Recurrent fungal infections (HP:0002841)3.23830981
12Recurrent cutaneous fungal infections (HP:0011370)3.17155242
13Chronic mucocutaneous candidiasis (HP:0002728)3.17155242
14Recurrent bacterial skin infections (HP:0005406)3.16362270
15Acute myeloid leukemia (HP:0004808)3.13259660
16Gastrointestinal inflammation (HP:0004386)3.06888182
17Thyroiditis (HP:0100646)3.05690813
18IgG deficiency (HP:0004315)2.96192703
19Combined immunodeficiency (HP:0005387)2.94972945
20IgM deficiency (HP:0002850)2.94121286
21Leukocytosis (HP:0001974)2.92125501
22Prolonged bleeding time (HP:0003010)2.91616639
23Abnormality of eosinophils (HP:0001879)2.91410599
24Panhypogammaglobulinemia (HP:0003139)2.86860119
25Abnormality of T cell physiology (HP:0011840)2.75417339
26Abnormality of B cell number (HP:0010975)2.74247697
27Abnormality of the fingertips (HP:0001211)2.71994852
28IgA deficiency (HP:0002720)2.71412211
29Recurrent abscess formation (HP:0002722)2.69524228
30Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.67183355
31Eczematoid dermatitis (HP:0000976)2.64058264
32Optic neuritis (HP:0100653)2.63394028
33Retrobulbar optic neuritis (HP:0100654)2.63394028
34Gingival bleeding (HP:0000225)2.62748827
35Eosinophilia (HP:0001880)2.61474003
36Gastrointestinal infarctions (HP:0005244)2.61093817
37Colitis (HP:0002583)2.59462800
38Encephalitis (HP:0002383)2.59275775
39Granulocytopenia (HP:0001913)2.59101781
40B lymphocytopenia (HP:0010976)2.58489094
41Mediastinal lymphadenopathy (HP:0100721)2.53982949
42Viral hepatitis (HP:0006562)2.53954131
43Chromosomal breakage induced by crosslinking agents (HP:0003221)2.51731359
44Spontaneous hematomas (HP:0007420)2.51231129
45Elevated erythrocyte sedimentation rate (HP:0003565)2.49679158
46Epistaxis (HP:0000421)2.48931372
47Abnormality of the prostate (HP:0008775)2.48752375
48Curly hair (HP:0002212)2.45530365
49Subacute progressive viral hepatitis (HP:0006572)2.45446576
50Recurrent skin infections (HP:0001581)2.44784388
51Chest pain (HP:0100749)2.43378625
52Myositis (HP:0100614)2.40675627
53Meningitis (HP:0001287)2.40584560
54Prominent nose (HP:0000448)2.40341655
55Stomach cancer (HP:0012126)2.35331964
56Vasculitis (HP:0002633)2.32799731
57Autoimmune thrombocytopenia (HP:0001973)2.31619729
58Lymphoma (HP:0002665)2.31029984
59Keratoconjunctivitis sicca (HP:0001097)2.30387273
60Chromsome breakage (HP:0040012)2.30038015
61Hypoplasia of the thymus (HP:0000778)2.29584354
62Arterial thrombosis (HP:0004420)2.25320865
63Increased IgM level (HP:0003496)2.25143462
64Myelodysplasia (HP:0002863)2.24660033
65Recurrent bronchitis (HP:0002837)2.23593708
66Basal cell carcinoma (HP:0002671)2.23009722
67Acute hepatic failure (HP:0006554)2.22652172
68Fatigue (HP:0012378)2.19220324
69Orchitis (HP:0100796)2.18446507
70Pulmonary infiltrates (HP:0002113)2.18434663
71Papillary thyroid carcinoma (HP:0002895)2.17533896
72Abnormality of chromosome stability (HP:0003220)2.13907053
73Keratoconjunctivitis (HP:0001096)2.13141856
74Agammaglobulinemia (HP:0004432)2.11801720
75Pustule (HP:0200039)2.11119675
76Amaurosis fugax (HP:0100576)2.06578424
77Abnormal platelet volume (HP:0011876)2.06315785
78Neoplasm of the tracheobronchial system (HP:0100552)2.05748911
79Abnormality of macrophages (HP:0004311)2.02417740
80Prostate neoplasm (HP:0100787)2.01181801
81Acute lymphatic leukemia (HP:0006721)1.95072720
82Clubbing of toes (HP:0100760)1.94161886
83Slow saccadic eye movements (HP:0000514)1.93687185
84Submucous cleft hard palate (HP:0000176)1.92108430
85Alveolar cell carcinoma (HP:0006519)1.90825477
86Increased mean platelet volume (HP:0011877)1.89928041
87Poikilocytosis (HP:0004447)1.87560143
88Lymphopenia (HP:0001888)1.81272705
89Fair hair (HP:0002286)1.80701070
90Sandal gap (HP:0001852)1.78373985
91Somatic mutation (HP:0001428)1.78100543
92Hemoptysis (HP:0002105)1.76116331
93Gingivitis (HP:0000230)1.74901152
94Osteomyelitis (HP:0002754)1.74678038
95Abnormality of cells of the lymphoid lineage (HP:0012140)1.73439228
96Periodontitis (HP:0000704)1.71783739
97Abnormality of DNA repair (HP:0003254)1.71430627
98Cellulitis (HP:0100658)1.71320526
99Cystic hygroma (HP:0000476)1.71203371
100Deep philtrum (HP:0002002)1.70388753

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.27566773
2BRD43.05719414
3TXK2.86810217
4TAOK32.52871302
5MAP4K12.46082209
6BMPR22.44085446
7TEC2.36355782
8MAP3K142.30740099
9RIPK42.25316127
10ACVR1B2.21938955
11BTK1.96655843
12MARK31.80876660
13IKBKE1.73364499
14SIK31.72993680
15TSSK61.72366502
16MST41.67104789
17GRK61.65385629
18BLK1.62707458
19JAK11.60575677
20FES1.59402633
21JAK31.59181812
22PIM11.57325553
23SCYL21.56047924
24FRK1.52928743
25ITK1.52461190
26IRAK41.52196196
27NLK1.50126805
28EIF2AK31.46574950
29ZAP701.37619414
30TYK21.34406979
31SYK1.34022542
32CSK1.33827026
33HCK1.33158836
34IKBKB1.29020222
35IRAK11.26560939
36AKT31.20503705
37TRPM71.17469651
38MAP2K31.17167165
39PIK3CG1.13731765
40LCK1.13068153
41MAP3K21.12579431
42PRPF4B1.11435884
43JAK21.06722928
44CDK61.04545865
45SGK20.98037483
46FGR0.97117927
47LATS10.96943356
48KSR10.94416107
49MKNK20.90410454
50LYN0.89951963
51CDK40.89482890
52WNK10.87172492
53STK100.87027470
54PLK40.86445773
55KSR20.84715978
56CHUK0.84490632
57RAF10.84332850
58BRSK20.83447852
59MAP3K50.82508275
60FGFR30.82090488
61MELK0.79945932
62IRAK20.77857932
63NEK60.76735586
64NUAK10.74917202
65BMPR1B0.73294925
66CLK10.68808645
67MAPK110.67163588
68MAP3K100.64396639
69ERBB30.63213061
70PRKCQ0.62513297
71SGK30.60415244
72EGFR0.60358424
73STK40.59955276
74CAMK1D0.59813313
75TBK10.57711600
76PIK3CA0.55195441
77CSF1R0.54401568
78YES10.54383359
79MAP3K60.53823405
80SRPK10.50676220
81ATR0.50540132
82KIT0.49844207
83PDGFRB0.48948299
84ZAK0.44776787
85CDK80.44654845
86DYRK1A0.44564468
87MAP3K130.43249358
88PRKAA20.43015014
89CHEK10.40649316
90ATM0.40631699
91TNK20.40448369
92FLT30.39113966
93MARK20.37381754
94MAP3K30.37148022
95MKNK10.36775102
96STK30.35390273
97DYRK30.35015101
98PDK10.33485043
99SGK10.33474343
100RPS6KB20.32881078

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.67234545
2T cell receptor signaling pathway_Homo sapiens_hsa046602.49595832
3B cell receptor signaling pathway_Homo sapiens_hsa046622.29155229
4NF-kappa B signaling pathway_Homo sapiens_hsa040642.23279120
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.19776406
6Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.19137660
7Measles_Homo sapiens_hsa051622.16932341
8Hematopoietic cell lineage_Homo sapiens_hsa046401.94179713
9NOD-like receptor signaling pathway_Homo sapiens_hsa046211.93404994
10Jak-STAT signaling pathway_Homo sapiens_hsa046301.92993820
11Allograft rejection_Homo sapiens_hsa053301.90604317
12Leishmaniasis_Homo sapiens_hsa051401.89961618
13Graft-versus-host disease_Homo sapiens_hsa053321.87960942
14Autoimmune thyroid disease_Homo sapiens_hsa053201.85536065
15RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.77543830
16Acute myeloid leukemia_Homo sapiens_hsa052211.75384046
17Osteoclast differentiation_Homo sapiens_hsa043801.69045277
18Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.68347288
19Non-small cell lung cancer_Homo sapiens_hsa052231.62937971
20Asthma_Homo sapiens_hsa053101.62793730
21Legionellosis_Homo sapiens_hsa051341.60572391
22Hepatitis B_Homo sapiens_hsa051611.58581810
23TNF signaling pathway_Homo sapiens_hsa046681.51342123
24Toll-like receptor signaling pathway_Homo sapiens_hsa046201.50582371
25Herpes simplex infection_Homo sapiens_hsa051681.50406408
26Influenza A_Homo sapiens_hsa051641.47335397
27Intestinal immune network for IgA production_Homo sapiens_hsa046721.39951007
28Antigen processing and presentation_Homo sapiens_hsa046121.39235479
29Apoptosis_Homo sapiens_hsa042101.37988148
30Toxoplasmosis_Homo sapiens_hsa051451.30197522
31Chronic myeloid leukemia_Homo sapiens_hsa052201.29122423
32Pancreatic cancer_Homo sapiens_hsa052121.27427346
33Viral carcinogenesis_Homo sapiens_hsa052031.26761131
34Dorso-ventral axis formation_Homo sapiens_hsa043201.23067650
35FoxO signaling pathway_Homo sapiens_hsa040681.22234454
36Tuberculosis_Homo sapiens_hsa051521.21790769
37Transcriptional misregulation in cancer_Homo sapiens_hsa052021.20000580
38Type I diabetes mellitus_Homo sapiens_hsa049401.17121773
39Platelet activation_Homo sapiens_hsa046111.14362107
40Prolactin signaling pathway_Homo sapiens_hsa049171.12081978
41Systemic lupus erythematosus_Homo sapiens_hsa053221.08954459
42Colorectal cancer_Homo sapiens_hsa052101.07109959
43Viral myocarditis_Homo sapiens_hsa054161.07074902
44p53 signaling pathway_Homo sapiens_hsa041151.04358709
45Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.02974969
46Chemokine signaling pathway_Homo sapiens_hsa040621.01577491
47Prostate cancer_Homo sapiens_hsa052151.01396814
48Phosphatidylinositol signaling system_Homo sapiens_hsa040701.00850501
49Endometrial cancer_Homo sapiens_hsa052131.00362700
50Malaria_Homo sapiens_hsa051441.00027242
51Renal cell carcinoma_Homo sapiens_hsa052110.97551298
52Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.96525270
53Epstein-Barr virus infection_Homo sapiens_hsa051690.95951001
54Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.95742068
55mRNA surveillance pathway_Homo sapiens_hsa030150.95285849
56Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.94535692
57Cell cycle_Homo sapiens_hsa041100.92520367
58Hepatitis C_Homo sapiens_hsa051600.90552652
59HTLV-I infection_Homo sapiens_hsa051660.89413802
60Staphylococcus aureus infection_Homo sapiens_hsa051500.87415729
61Non-homologous end-joining_Homo sapiens_hsa034500.84736813
62Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.84178773
63Inositol phosphate metabolism_Homo sapiens_hsa005620.84162005
64MicroRNAs in cancer_Homo sapiens_hsa052060.83730088
65Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.82759757
66Fanconi anemia pathway_Homo sapiens_hsa034600.81423572
67Shigellosis_Homo sapiens_hsa051310.79486762
68Choline metabolism in cancer_Homo sapiens_hsa052310.77496271
69AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.74745732
70RNA transport_Homo sapiens_hsa030130.72422962
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.71811265
72mTOR signaling pathway_Homo sapiens_hsa041500.71543946
73Sphingolipid signaling pathway_Homo sapiens_hsa040710.68716735
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.68704475
75ErbB signaling pathway_Homo sapiens_hsa040120.68270703
76Small cell lung cancer_Homo sapiens_hsa052220.68114081
77Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.68049460
78RNA degradation_Homo sapiens_hsa030180.67983709
79Glioma_Homo sapiens_hsa052140.64970786
80African trypanosomiasis_Homo sapiens_hsa051430.62124889
81VEGF signaling pathway_Homo sapiens_hsa043700.61713444
82Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59691421
83Thyroid cancer_Homo sapiens_hsa052160.58814703
84Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57457129
85Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55021208
86Basal transcription factors_Homo sapiens_hsa030220.54833297
87HIF-1 signaling pathway_Homo sapiens_hsa040660.54590140
88Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.52714141
89Regulation of autophagy_Homo sapiens_hsa041400.52563446
90Rheumatoid arthritis_Homo sapiens_hsa053230.51472574
91Insulin resistance_Homo sapiens_hsa049310.51412870
92MAPK signaling pathway_Homo sapiens_hsa040100.51015001
93Leukocyte transendothelial migration_Homo sapiens_hsa046700.50665386
94Alcoholism_Homo sapiens_hsa050340.49869824
95Lysine degradation_Homo sapiens_hsa003100.43810328
96Salmonella infection_Homo sapiens_hsa051320.43133570
97Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.42464141
98Adipocytokine signaling pathway_Homo sapiens_hsa049200.40348336
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37530959
100Pertussis_Homo sapiens_hsa051330.37106249

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