SMG1P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of developmental pigmentation (GO:0048087)5.58343253
2histone H3-K4 trimethylation (GO:0080182)5.36559247
3cellular response to ethanol (GO:0071361)5.32757098
4phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)5.29130975
5regulation of pigment cell differentiation (GO:0050932)5.08081963
6interkinetic nuclear migration (GO:0022027)4.62841585
7monoubiquitinated protein deubiquitination (GO:0035520)4.51754252
8regulation of B cell receptor signaling pathway (GO:0050855)4.38283015
9B cell receptor signaling pathway (GO:0050853)4.30682505
10positive regulation of granulocyte differentiation (GO:0030854)4.28378954
11positive regulation of gamma-delta T cell activation (GO:0046645)4.22350407
12histone H3-K36 demethylation (GO:0070544)4.19256247
13phospholipid translocation (GO:0045332)4.18163995
14lipid translocation (GO:0034204)4.18163995
15nuclear pore complex assembly (GO:0051292)4.17906900
16peptidyl-lysine trimethylation (GO:0018023)4.16800369
17cytoplasmic mRNA processing body assembly (GO:0033962)3.90437883
18regulation of histone H3-K27 methylation (GO:0061085)3.76112838
19establishment of protein localization to Golgi (GO:0072600)3.74413137
20negative T cell selection (GO:0043383)3.74383673
21negative thymic T cell selection (GO:0045060)3.71772542
22peptidyl-lysine methylation (GO:0018022)3.64580218
23regulation of establishment of cell polarity (GO:2000114)3.58240663
24histone H3-K4 methylation (GO:0051568)3.55918143
25protein K48-linked deubiquitination (GO:0071108)3.54532993
26negative regulation of DNA repair (GO:0045738)3.52899424
27nuclear pore organization (GO:0006999)3.48624544
28regulation of gamma-delta T cell activation (GO:0046643)3.43286514
29CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.41596444
30oocyte development (GO:0048599)3.40948188
31T cell lineage commitment (GO:0002360)3.38889982
32positive T cell selection (GO:0043368)3.28034989
33regulation of interleukin-12 biosynthetic process (GO:0045075)3.27164834
34mature B cell differentiation (GO:0002335)3.23062678
35negative regulation of translation, ncRNA-mediated (GO:0040033)3.21304004
36regulation of translation, ncRNA-mediated (GO:0045974)3.21304004
37negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.21304004
38regulation of MHC class I biosynthetic process (GO:0045343)3.20984522
39germinal center formation (GO:0002467)3.18999943
40regulation of gamma-delta T cell differentiation (GO:0045586)3.17911999
41B cell homeostasis (GO:0001782)3.10681028
42histone lysine demethylation (GO:0070076)3.10244649
43regulation of protein polyubiquitination (GO:1902914)3.09095376
44histone lysine methylation (GO:0034968)3.06996967
45pore complex assembly (GO:0046931)3.06220973
46histone demethylation (GO:0016577)3.05582047
47snRNA transcription (GO:0009301)3.04087125
48retrograde transport, vesicle recycling within Golgi (GO:0000301)3.02633056
49histone H3-K9 demethylation (GO:0033169)3.00383097
50negative regulation of osteoblast proliferation (GO:0033689)2.98930556
51regulation of establishment or maintenance of cell polarity (GO:0032878)2.98289843
52protein targeting to Golgi (GO:0000042)2.97082566
53histone mRNA catabolic process (GO:0071044)2.96779596
54protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.91730546
55negative regulation of myotube differentiation (GO:0010832)2.90006201
56regulation of developmental pigmentation (GO:0048070)2.88071959
57negative regulation of B cell proliferation (GO:0030889)2.87966547
58striated muscle atrophy (GO:0014891)2.87713108
59negative regulation of calcium ion transport into cytosol (GO:0010523)2.85558749
60regulation of alpha-beta T cell proliferation (GO:0046640)2.82663336
61phosphatidylinositol phosphorylation (GO:0046854)2.81949580
62pre-miRNA processing (GO:0031054)2.78459450
63Golgi to endosome transport (GO:0006895)2.78114794
64hepatocyte apoptotic process (GO:0097284)2.78107300
65positive thymic T cell selection (GO:0045059)2.78066907
66corticosteroid receptor signaling pathway (GO:0031958)2.76900748
67B cell proliferation (GO:0042100)2.76184232
68nucleus localization (GO:0051647)2.75845944
69dosage compensation (GO:0007549)2.74091753
70detection of molecule of bacterial origin (GO:0032490)2.73043228
71skeletal muscle adaptation (GO:0043501)2.72079547
72definitive hemopoiesis (GO:0060216)2.70274466
73regulation of granulocyte differentiation (GO:0030852)2.70177955
74T cell selection (GO:0045058)2.69123372
75histone H3-K9 methylation (GO:0051567)2.67947252
76protein K11-linked deubiquitination (GO:0035871)2.66895720
77histone H3-K9 modification (GO:0061647)2.66743117
78regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.65513196
79glucocorticoid receptor signaling pathway (GO:0042921)2.65366712
80positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.63228021
81protein demethylation (GO:0006482)2.62234991
82protein dealkylation (GO:0008214)2.62234991
83mature B cell differentiation involved in immune response (GO:0002313)2.60758053
84protein K63-linked deubiquitination (GO:0070536)2.56061619
85regulation of membrane lipid distribution (GO:0097035)2.55799431
86regulation of B cell proliferation (GO:0030888)2.55533413
87replicative senescence (GO:0090399)2.55241481
88melanocyte differentiation (GO:0030318)2.54499651
89regulation of necroptotic process (GO:0060544)2.52351919
90positive regulation of protein import into nucleus, translocation (GO:0033160)2.51119886
91pericardium development (GO:0060039)2.51097118
92T cell migration (GO:0072678)2.51038491
93positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.50525011
94thymic T cell selection (GO:0045061)2.49763543
95necrotic cell death (GO:0070265)2.47643801
96response to muramyl dipeptide (GO:0032495)2.47148244
97regulation of RNA export from nucleus (GO:0046831)2.45590437
98positive regulation of alpha-beta T cell proliferation (GO:0046641)2.43073497
99cerebellar Purkinje cell differentiation (GO:0021702)2.42316979
100negative regulation of T cell mediated immunity (GO:0002710)2.41806164

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.24521105
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.82533628
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.44706937
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.41496388
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.25209177
6SMAD_19615063_ChIP-ChIP_OVARY_Human3.18107453
7GATA1_22025678_ChIP-Seq_K562_Human2.97658012
8CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.84543209
9RUNX_20019798_ChIP-Seq_JUKART_Human2.37766978
10SCL_19346495_ChIP-Seq_HPC-7_Human2.36288815
11VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.31079909
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.25111931
13SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.08456247
14STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.02038927
15TP53_16413492_ChIP-PET_HCT116_Human1.98830655
16ZNF217_24962896_ChIP-Seq_MCF-7_Human1.94785867
17CDX2_19796622_ChIP-Seq_MESCs_Mouse1.94469857
18Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.86722255
19AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.85283245
20PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.83396758
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.78922648
22AHR_22903824_ChIP-Seq_MCF-7_Human1.74236060
23SALL1_21062744_ChIP-ChIP_HESCs_Human1.72855627
24FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.72666130
25MYB_26560356_Chip-Seq_TH2_Human1.69030993
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.68591824
27NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.67036684
28AR_21572438_ChIP-Seq_LNCaP_Human1.66356920
29SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.65713089
30CTNNB1_20460455_ChIP-Seq_HCT116_Human1.59026978
31EGR1_19374776_ChIP-ChIP_THP-1_Human1.58106317
32STAT3_23295773_ChIP-Seq_U87_Human1.57953579
33TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.56725870
34IRF8_27001747_Chip-Seq_BMDM_Mouse1.56162587
35MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.55884716
36FLI1_27457419_Chip-Seq_LIVER_Mouse1.55774802
37POU3F2_20337985_ChIP-ChIP_501MEL_Human1.55015719
38MYB_21317192_ChIP-Seq_ERMYB_Mouse1.52652818
39VDR_24787735_ChIP-Seq_THP-1_Human1.50122477
40GBX2_23144817_ChIP-Seq_PC3_Human1.45226647
41GATA3_27048872_Chip-Seq_THYMUS_Human1.43075970
42ARNT_22903824_ChIP-Seq_MCF-7_Human1.42396277
43MYB_26560356_Chip-Seq_TH1_Human1.42192941
44ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.35656606
45PCGF2_27294783_Chip-Seq_NPCs_Mouse1.30868748
46FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.30195879
47ESR1_20079471_ChIP-ChIP_T-47D_Human1.29220105
48TAF15_26573619_Chip-Seq_HEK293_Human1.28940337
49RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.28680095
50GATA2_21666600_ChIP-Seq_HMVEC_Human1.28568039
51PCGF2_27294783_Chip-Seq_ESCs_Mouse1.27183424
52PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.23836247
53TCF4_23295773_ChIP-Seq_U87_Human1.23114666
54NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.22115035
55NOTCH1_21737748_ChIP-Seq_TLL_Human1.20959947
56CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.20818762
57RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20681288
58KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.19440980
59SMAD4_21799915_ChIP-Seq_A2780_Human1.18734562
60GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18662826
61PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18597047
62FOXA2_19822575_ChIP-Seq_HepG2_Human1.18558916
63IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.16020272
64CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.14790417
65FOXO3_23340844_ChIP-Seq_DLD1_Human1.14272784
66NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.11960005
67ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10647744
68ER_23166858_ChIP-Seq_MCF-7_Human1.09621647
69SUZ12_27294783_Chip-Seq_NPCs_Mouse1.09104950
70MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08904157
71TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08504424
72POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08504424
73GATA3_26560356_Chip-Seq_TH2_Human1.07725184
74GATA2_19941826_ChIP-Seq_K562_Human1.06907359
75BRD4_25478319_ChIP-Seq_HGPS_Human1.06495759
76BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.06271784
77IGF1R_20145208_ChIP-Seq_DFB_Human1.05508083
78EZH2_27294783_Chip-Seq_NPCs_Mouse1.04769063
79NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.04226848
80NRF2_20460467_ChIP-Seq_MEFs_Mouse1.04226848
81FOXM1_26456572_ChIP-Seq_MCF-7_Human1.04115454
82SPI1_23127762_ChIP-Seq_K562_Human1.03462952
83RXR_22108803_ChIP-Seq_LS180_Human1.02455221
84PIAS1_25552417_ChIP-Seq_VCAP_Human1.01161507
85PRDM14_20953172_ChIP-Seq_ESCs_Human1.01006427
86TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00864607
87ZFP57_27257070_Chip-Seq_ESCs_Mouse1.00562702
88SOX9_24532713_ChIP-Seq_HFSC_Mouse1.00034943
89PU_27001747_Chip-Seq_BMDM_Mouse0.99869095
90IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.98582848
91IRF8_21731497_ChIP-ChIP_J774_Mouse0.98314563
92FLI1_21867929_ChIP-Seq_TH2_Mouse0.97395470
93GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.96026391
94NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94702950
95MYC_22102868_ChIP-Seq_BL_Human0.94512592
96IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.94263191
97CBP_20019798_ChIP-Seq_JUKART_Human0.94263191
98E2F7_22180533_ChIP-Seq_HELA_Human0.93098695
99GATA1_19941827_ChIP-Seq_MEL_Mouse0.92955705
100FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.92774282

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.74287481
2MP0000569_abnormal_digit_pigmentation5.31634163
3MP0003763_abnormal_thymus_physiology3.70243534
4MP0002009_preneoplasia3.39223950
5MP0004381_abnormal_hair_follicle3.33659474
6MP0003045_fibrosis3.24298292
7MP0001835_abnormal_antigen_presentation2.37112567
8MP0002396_abnormal_hematopoietic_system2.32464140
9MP0000383_abnormal_hair_follicle2.28856006
10MP0005075_abnormal_melanosome_morpholog2.28187326
11MP0002166_altered_tumor_susceptibility2.24719488
12MP0000372_irregular_coat_pigmentation2.18808683
13MP0005076_abnormal_cell_differentiation2.10504996
14MP0010352_gastrointestinal_tract_polyps2.08232636
15MP0000685_abnormal_immune_system2.01545492
16MP0001800_abnormal_humoral_immune1.96213289
17MP0000371_diluted_coat_color1.94934791
18MP0002168_other_aberrant_phenotype1.86771112
19MP0000015_abnormal_ear_pigmentation1.82409874
20MP0005310_abnormal_salivary_gland1.81924553
21MP0010307_abnormal_tumor_latency1.74413891
22MP0005408_hypopigmentation1.68628027
23MP0010678_abnormal_skin_adnexa1.65488718
24MP0004808_abnormal_hematopoietic_stem1.60770607
25MP0002398_abnormal_bone_marrow1.54675679
26MP0003091_abnormal_cell_migration1.50806112
27MP0003300_gastrointestinal_ulcer1.49654921
28MP0005174_abnormal_tail_pigmentation1.47922345
29MP0000703_abnormal_thymus_morphology1.43194284
30MP0002420_abnormal_adaptive_immunity1.39782347
31MP0002006_tumorigenesis1.39025516
32MP0002452_abnormal_antigen_presenting1.37167167
33MP0003656_abnormal_erythrocyte_physiolo1.37034808
34MP0003950_abnormal_plasma_membrane1.35687089
35MP0001819_abnormal_immune_cell1.35432795
36MP0008961_abnormal_basal_metabolism1.34995719
37MP0003890_abnormal_embryonic-extraembry1.31516221
38MP0002723_abnormal_immune_serum1.29318067
39MP0000689_abnormal_spleen_morphology1.28676549
40MP0005387_immune_system_phenotype1.27819985
41MP0001790_abnormal_immune_system1.27819985
42MP0003828_pulmonary_edema1.27479382
43MP0005671_abnormal_response_to1.27041753
44MP0004145_abnormal_muscle_electrophysio1.26889147
45MP0003646_muscle_fatigue1.26880791
46MP0000716_abnormal_immune_system1.26181145
47MP0002722_abnormal_immune_system1.23995068
48MP0005000_abnormal_immune_tolerance1.22508820
49MP0003866_abnormal_defecation1.20155341
50MP0000427_abnormal_hair_cycle1.18848180
51MP0002419_abnormal_innate_immunity1.15201379
52MP0002405_respiratory_system_inflammati1.13841237
53MP0004947_skin_inflammation1.12371878
54MP0005397_hematopoietic_system_phenotyp1.10706902
55MP0001545_abnormal_hematopoietic_system1.10706902
56MP0000465_gastrointestinal_hemorrhage1.07739520
57MP0002332_abnormal_exercise_endurance1.07210114
58MP0005621_abnormal_cell_physiology1.04396518
59MP0001873_stomach_inflammation1.01723655
60MP0008260_abnormal_autophagy1.01686038
61MP0003436_decreased_susceptibility_to1.00296094
62MP0009115_abnormal_fat_cell1.00011184
63MP0002075_abnormal_coat/hair_pigmentati0.98287245
64MP0004130_abnormal_muscle_cell0.97864658
65MP0002429_abnormal_blood_cell0.97337024
66MP0001851_eye_inflammation0.96664820
67MP0006054_spinal_hemorrhage0.96228544
68MP0010155_abnormal_intestine_physiology0.95045640
69MP0010094_abnormal_chromosome_stability0.94506452
70MP0004264_abnormal_extraembryonic_tissu0.88671287
71MP0005464_abnormal_platelet_physiology0.87097884
72MP0002095_abnormal_skin_pigmentation0.86260552
73MP0004484_altered_response_of0.85237651
74MP0000733_abnormal_muscle_development0.83751112
75MP0003868_abnormal_feces_composition0.82506114
76MP0005409_darkened_coat_color0.82403255
77MP0003172_abnormal_lysosome_physiology0.82391355
78MP0005167_abnormal_blood-brain_barrier0.82031039
79MP0001915_intracranial_hemorrhage0.80548879
80MP0005395_other_phenotype0.80014862
81MP0000249_abnormal_blood_vessel0.76614268
82MP0002019_abnormal_tumor_incidence0.76481993
83MP0003221_abnormal_cardiomyocyte_apopto0.75982332
84MP0003303_peritoneal_inflammation0.75738671
85MP0005025_abnormal_response_to0.75380524
86MP0001191_abnormal_skin_condition0.74390767
87MP0003077_abnormal_cell_cycle0.72889576
88MP0005266_abnormal_metabolism0.72500384
89MP0003984_embryonic_growth_retardation0.71733041
90MP0002088_abnormal_embryonic_growth/wei0.71631152
91MP0002998_abnormal_bone_remodeling0.71578651
92MP0002933_joint_inflammation0.70092222
93MP0008007_abnormal_cellular_replicative0.69191749
94MP0005451_abnormal_body_composition0.68717576
95MP0002086_abnormal_extraembryonic_tissu0.67879051
96MP0008995_early_reproductive_senescence0.67230136
97MP0001853_heart_inflammation0.67081857
98MP0004036_abnormal_muscle_relaxation0.65535691
99MP0003632_abnormal_nervous_system0.65433890
100MP0003724_increased_susceptibility_to0.64695729

Predicted human phenotypes

RankGene SetZ-score
1Submucous cleft hard palate (HP:0000176)4.84442230
2Abnormality of the fingertips (HP:0001211)4.70220467
3Colitis (HP:0002583)4.30539801
4Chin dimple (HP:0010751)3.79689566
5T lymphocytopenia (HP:0005403)3.62027085
6IgA deficiency (HP:0002720)3.45428787
7Abnormality of T cell number (HP:0011839)3.41553750
8Thoracolumbar scoliosis (HP:0002944)3.40150092
9Autoimmune hemolytic anemia (HP:0001890)3.33655544
10Abnormal delayed hypersensitivity skin test (HP:0002963)3.31082597
11Overlapping toe (HP:0001845)3.16803831
12Genetic anticipation (HP:0003743)3.15627021
13Short chin (HP:0000331)2.95137319
14Dysmetric saccades (HP:0000641)2.94419437
15IgM deficiency (HP:0002850)2.92117712
16Sandal gap (HP:0001852)2.91560131
17Acute myeloid leukemia (HP:0004808)2.89864333
18Prominent nose (HP:0000448)2.84541282
19Inflammation of the large intestine (HP:0002037)2.72631283
20Recurrent cutaneous fungal infections (HP:0011370)2.69646273
21Chronic mucocutaneous candidiasis (HP:0002728)2.69646273
22Viral hepatitis (HP:0006562)2.64642836
23Distal arthrogryposis (HP:0005684)2.63527033
24Narrow palate (HP:0000189)2.56281974
25Papillary thyroid carcinoma (HP:0002895)2.54705495
26Recurrent viral infections (HP:0004429)2.54410910
27Panhypogammaglobulinemia (HP:0003139)2.51104545
28Chronic diarrhea (HP:0002028)2.49832597
29Fair hair (HP:0002286)2.48205053
30Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.44016415
31Widely spaced teeth (HP:0000687)2.42114094
32Clubbing of toes (HP:0100760)2.41147971
33Gaze-evoked nystagmus (HP:0000640)2.40602544
34Heterotopia (HP:0002282)2.38594460
35Hypoplasia of the thymus (HP:0000778)2.38260614
36Gastrointestinal inflammation (HP:0004386)2.36926158
37Subacute progressive viral hepatitis (HP:0006572)2.36007235
38Abnormality of T cells (HP:0002843)2.31983896
39Protruding tongue (HP:0010808)2.28018699
40Truncal obesity (HP:0001956)2.27911457
41Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.26594936
42Recurrent fungal infections (HP:0002841)2.23836816
43Mediastinal lymphadenopathy (HP:0100721)2.22104451
44Thyroiditis (HP:0100646)2.19107982
45Generalized hypopigmentation of hair (HP:0011358)2.18730312
46Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.16478559
47Neonatal hypoglycemia (HP:0001998)2.15175640
48Scanning speech (HP:0002168)2.09286821
49Tented upper lip vermilion (HP:0010804)2.03174058
50Agammaglobulinemia (HP:0004432)2.02838546
51Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.99141375
52Chromosomal breakage induced by crosslinking agents (HP:0003221)1.96787247
53Persistence of primary teeth (HP:0006335)1.96140251
54Chromsome breakage (HP:0040012)1.94977140
55Blue irides (HP:0000635)1.94381211
56Febrile seizures (HP:0002373)1.94238397
57Abnormality of chromosome stability (HP:0003220)1.93788263
58Abnormality of the nasal septum (HP:0000419)1.93521882
59Abnormality of incisor morphology (HP:0011063)1.90629948
60Abnormality of T cell physiology (HP:0011840)1.90372392
61Abnormality of the epiphyses of the hand (HP:0005924)1.90311508
62Clumsiness (HP:0002312)1.89347050
63Stomach cancer (HP:0012126)1.84482746
64Overgrowth (HP:0001548)1.82966941
65Abnormal finger flexion creases (HP:0006143)1.82414708
66Hyperkalemia (HP:0002153)1.82341617
67Slow saccadic eye movements (HP:0000514)1.81486479
68Macroorchidism (HP:0000053)1.80962903
69Hepatitis (HP:0012115)1.79904931
70Hematochezia (HP:0002573)1.79805728
71Recurrent bronchitis (HP:0002837)1.79681422
72Mask-like facies (HP:0000298)1.78703221
73Basal cell carcinoma (HP:0002671)1.78452070
74Progressive cerebellar ataxia (HP:0002073)1.78286790
75Dislocated radial head (HP:0003083)1.78210930
76Neoplasm of the tracheobronchial system (HP:0100552)1.78163161
77Hypopigmentation of the fundus (HP:0007894)1.77369695
78Thick eyebrow (HP:0000574)1.76717584
79Low anterior hairline (HP:0000294)1.75167326
80Autoimmune thrombocytopenia (HP:0001973)1.75158772
81Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.73596407
82Acute lymphatic leukemia (HP:0006721)1.73441972
83Cubitus valgus (HP:0002967)1.72717703
84Spondylolisthesis (HP:0003302)1.71682220
85Chronic hepatic failure (HP:0100626)1.71656790
86Conjunctival telangiectasia (HP:0000524)1.71261372
87Long eyelashes (HP:0000527)1.70292130
88Absent frontal sinuses (HP:0002688)1.69938714
89Tapered finger (HP:0001182)1.69364204
90Hyperventilation (HP:0002883)1.69313303
91Down-sloping shoulders (HP:0200021)1.68154388
92Limited hip movement (HP:0008800)1.66620230
93Aortic aneurysm (HP:0004942)1.65600075
94Acanthocytosis (HP:0001927)1.64561658
95Meningitis (HP:0001287)1.59308566
96Abnormal glucose tolerance (HP:0001952)1.57998031
97Duplicated collecting system (HP:0000081)1.57754492
98Abnormality of the radial head (HP:0003995)1.57322461
99Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.56650647
100Lymphopenia (HP:0001888)1.55220204

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.35844528
2CDK123.58626439
3BRD42.65128380
4AKT32.57674486
5TAOK32.32855812
6TRPM72.28034294
7ACVR1B2.18454174
8MELK2.08697306
9BLK2.08229191
10SGK22.01067420
11CAMK1D1.96865879
12TEC1.83115450
13NLK1.73717077
14JAK11.70069827
15CAMK1G1.66774626
16OBSCN1.65052631
17MAP3K71.63745405
18BMPR1B1.55201977
19BTK1.48379154
20EEF2K1.47551465
21WNK11.45558805
22PIK3CG1.43486721
23SGK31.42025285
24MAPK131.38646448
25MAPK111.36905017
26MAP3K141.34679130
27FGFR31.33929602
28MAP3K131.32032476
29PKN21.30581685
30MAP4K11.28411550
31MKNK21.22076641
32IKBKE1.21934997
33MARK21.20463793
34BMPR21.17460853
35TXK1.16331841
36ITK1.16300073
37PRKAA21.14947214
38SGK4941.12158389
39SGK2231.12158389
40PIK3CA1.10505199
41SYK1.10052787
42CHUK1.07216120
43HCK1.06953471
44PIM11.06648983
45MAP2K31.06012373
46CDC42BPA1.04651715
47MAP3K61.02006853
48MAP3K100.89402216
49PDGFRB0.86964685
50MAP3K40.86355147
51RIPK40.85290415
52LATS10.84248116
53TTN0.83784611
54EPHA30.82186558
55MTOR0.80526515
56ZAK0.80296224
57SGK10.79073296
58MARK30.77317375
59JAK20.75252690
60CDK60.73610267
61LCK0.72348829
62RET0.72205779
63IRAK10.71529258
64ZAP700.71304842
65IKBKB0.70411543
66MAP3K20.69435195
67FLT30.67678238
68RPS6KB20.66340804
69NEK90.65818495
70KIT0.64238051
71PDK10.64095551
72FES0.62994258
73NEK60.62859273
74JAK30.62713197
75MAPK70.62644245
76MAP3K50.62205868
77CAMK40.59854259
78STK38L0.59808620
79CAMKK20.58856580
80TYK20.58409268
81PTK2B0.58268374
82PRKAA10.55979643
83ICK0.51350233
84FGFR40.49108041
85LYN0.46877397
86ATM0.45860249
87ERBB20.45385594
88TLK10.44088773
89CDK40.43518653
90EGFR0.43364022
91GRK60.43120345
92ATR0.42201987
93STK240.41753850
94MAPK120.41422328
95CSK0.41350413
96CHEK10.40083248
97BRSK20.39725418
98EIF2AK30.39090570
99MAPK10.38615977
100MAPK100.38438372

Predicted pathways (KEGG)

RankGene SetZ-score
1B cell receptor signaling pathway_Homo sapiens_hsa046621.87093300
2Systemic lupus erythematosus_Homo sapiens_hsa053221.85630826
3NF-kappa B signaling pathway_Homo sapiens_hsa040641.84157019
4Phosphatidylinositol signaling system_Homo sapiens_hsa040701.84015041
5T cell receptor signaling pathway_Homo sapiens_hsa046601.69106638
6Lysine degradation_Homo sapiens_hsa003101.66530410
7Jak-STAT signaling pathway_Homo sapiens_hsa046301.49147681
8Non-small cell lung cancer_Homo sapiens_hsa052231.48735130
9Primary immunodeficiency_Homo sapiens_hsa053401.42889732
10TNF signaling pathway_Homo sapiens_hsa046681.41758009
11Inositol phosphate metabolism_Homo sapiens_hsa005621.41278075
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.39093424
13Intestinal immune network for IgA production_Homo sapiens_hsa046721.38825342
14Dorso-ventral axis formation_Homo sapiens_hsa043201.35992690
15Acute myeloid leukemia_Homo sapiens_hsa052211.35375353
16Pancreatic cancer_Homo sapiens_hsa052121.35147546
17Graft-versus-host disease_Homo sapiens_hsa053321.35108623
18ABC transporters_Homo sapiens_hsa020101.34524364
19Prostate cancer_Homo sapiens_hsa052151.33347606
20Osteoclast differentiation_Homo sapiens_hsa043801.33343451
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.33113458
22Colorectal cancer_Homo sapiens_hsa052101.31711449
23MicroRNAs in cancer_Homo sapiens_hsa052061.30808530
24Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.29085812
25Toxoplasmosis_Homo sapiens_hsa051451.28723481
26FoxO signaling pathway_Homo sapiens_hsa040681.27805765
27Measles_Homo sapiens_hsa051621.27702264
28Chronic myeloid leukemia_Homo sapiens_hsa052201.26091698
29NOD-like receptor signaling pathway_Homo sapiens_hsa046211.25702147
30Platelet activation_Homo sapiens_hsa046111.25229717
31AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.23957672
32Hepatitis B_Homo sapiens_hsa051611.23488676
33Small cell lung cancer_Homo sapiens_hsa052221.22637003
34Autoimmune thyroid disease_Homo sapiens_hsa053201.21914696
35Type II diabetes mellitus_Homo sapiens_hsa049301.19801367
36Allograft rejection_Homo sapiens_hsa053301.18619788
37Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.17370484
38mTOR signaling pathway_Homo sapiens_hsa041501.17033126
39Transcriptional misregulation in cancer_Homo sapiens_hsa052021.16547962
40Viral carcinogenesis_Homo sapiens_hsa052031.15101416
41Choline metabolism in cancer_Homo sapiens_hsa052311.12904585
42Circadian rhythm_Homo sapiens_hsa047101.11497691
43Prolactin signaling pathway_Homo sapiens_hsa049171.08325219
44Insulin resistance_Homo sapiens_hsa049311.08233017
45Influenza A_Homo sapiens_hsa051641.07560017
46Leishmaniasis_Homo sapiens_hsa051401.07029120
47Apoptosis_Homo sapiens_hsa042101.06497864
48Neurotrophin signaling pathway_Homo sapiens_hsa047221.01258016
49Toll-like receptor signaling pathway_Homo sapiens_hsa046201.00878363
50Longevity regulating pathway - mammal_Homo sapiens_hsa042110.97273999
51Endometrial cancer_Homo sapiens_hsa052130.96606803
52Alcoholism_Homo sapiens_hsa050340.96473907
53Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.95724596
54Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.95162903
55ErbB signaling pathway_Homo sapiens_hsa040120.93643179
56Hematopoietic cell lineage_Homo sapiens_hsa046400.93357028
57Thyroid hormone signaling pathway_Homo sapiens_hsa049190.92802920
58Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.92081425
59Adherens junction_Homo sapiens_hsa045200.91468440
60Tuberculosis_Homo sapiens_hsa051520.90348922
61Glioma_Homo sapiens_hsa052140.89658623
62GnRH signaling pathway_Homo sapiens_hsa049120.89123457
63Phospholipase D signaling pathway_Homo sapiens_hsa040720.88202023
64Hepatitis C_Homo sapiens_hsa051600.86559869
65Herpes simplex infection_Homo sapiens_hsa051680.86495105
66Renal cell carcinoma_Homo sapiens_hsa052110.85721050
67Fanconi anemia pathway_Homo sapiens_hsa034600.84721213
68Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.81891127
69Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.81283617
70Sphingolipid signaling pathway_Homo sapiens_hsa040710.80819162
71HIF-1 signaling pathway_Homo sapiens_hsa040660.80599742
72Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.79293193
73Leukocyte transendothelial migration_Homo sapiens_hsa046700.72387295
74MAPK signaling pathway_Homo sapiens_hsa040100.70718632
75Type I diabetes mellitus_Homo sapiens_hsa049400.69411503
76Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.68215776
77Non-homologous end-joining_Homo sapiens_hsa034500.66918698
78p53 signaling pathway_Homo sapiens_hsa041150.65081518
79VEGF signaling pathway_Homo sapiens_hsa043700.64623457
80Staphylococcus aureus infection_Homo sapiens_hsa051500.63926039
81Vascular smooth muscle contraction_Homo sapiens_hsa042700.63740309
82Asthma_Homo sapiens_hsa053100.63287220
83Viral myocarditis_Homo sapiens_hsa054160.62693320
84Proteoglycans in cancer_Homo sapiens_hsa052050.61147918
85Epstein-Barr virus infection_Homo sapiens_hsa051690.60466871
86Chemokine signaling pathway_Homo sapiens_hsa040620.60309661
87HTLV-I infection_Homo sapiens_hsa051660.59422656
88Focal adhesion_Homo sapiens_hsa045100.59388180
89Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.59363875
90Cholinergic synapse_Homo sapiens_hsa047250.58495483
91Aldosterone synthesis and secretion_Homo sapiens_hsa049250.58270713
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.58168999
93Long-term potentiation_Homo sapiens_hsa047200.57688954
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57429282
95Estrogen signaling pathway_Homo sapiens_hsa049150.54611741
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.52996770
97Taste transduction_Homo sapiens_hsa047420.50163753
98mRNA surveillance pathway_Homo sapiens_hsa030150.49869872
99Calcium signaling pathway_Homo sapiens_hsa040200.48737891
100Pathways in cancer_Homo sapiens_hsa052000.48463504

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