SMG1P5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of natural killer cell differentiation (GO:0032825)9.19050038
2positive regulation of interleukin-17 production (GO:0032740)7.59241268
3positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)6.54000918
4regulation of natural killer cell differentiation (GO:0032823)6.14115780
5regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)5.42227385
6positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)5.38623091
7positive regulation of natural killer cell mediated immunity (GO:0002717)5.34061206
8positive regulation of interferon-gamma biosynthetic process (GO:0045078)4.98862266
9positive regulation of natural killer cell activation (GO:0032816)4.92863721
10cellular response to interleukin-15 (GO:0071350)4.77394120
11positive regulation of interleukin-10 production (GO:0032733)4.73267723
12negative regulation of T-helper cell differentiation (GO:0045623)4.71923335
13negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)4.71923335
14response to interleukin-15 (GO:0070672)4.70348419
15regulation of interleukin-17 production (GO:0032660)4.51092170
16CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)4.35907471
17regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.30985183
18regulation of natural killer cell mediated immunity (GO:0002715)4.30985183
19regulation of isotype switching to IgG isotypes (GO:0048302)4.30168158
20negative regulation of adaptive immune response (GO:0002820)4.26077048
21regulation of MHC class II biosynthetic process (GO:0045346)4.15881331
22negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)4.14258122
23regulation of chronic inflammatory response (GO:0002676)4.11935671
24negative regulation of adaptive immune response based on somatic recombination of immune receptors b4.11084335
25negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.94087720
26negative regulation of cell killing (GO:0031342)3.94087720
27positive regulation of gamma-delta T cell activation (GO:0046645)3.91198438
28regulation of natural killer cell activation (GO:0032814)3.75386118
29positive regulation of B cell proliferation (GO:0030890)3.73570803
30regulation of interferon-gamma biosynthetic process (GO:0045072)3.68558743
31negative regulation of T cell mediated immunity (GO:0002710)3.66626746
32CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.58069812
33T-helper cell differentiation (GO:0042093)3.58069812
34production of molecular mediator of immune response (GO:0002440)3.58040088
35DNA double-strand break processing (GO:0000729)3.54641061
36negative regulation of alpha-beta T cell differentiation (GO:0046639)3.51629002
37defense response to protozoan (GO:0042832)3.43588637
38regulation of leukocyte mediated cytotoxicity (GO:0001910)3.43357800
39positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.39168186
40positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.37120493
41regulation of interleukin-10 production (GO:0032653)3.37116146
42phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.34592764
43regulation of B cell proliferation (GO:0030888)3.30805670
44alpha-beta T cell differentiation involved in immune response (GO:0002293)3.29267958
45alpha-beta T cell activation involved in immune response (GO:0002287)3.29267958
46T cell differentiation involved in immune response (GO:0002292)3.29267958
47regulation of cell killing (GO:0031341)3.20844172
48protein K11-linked deubiquitination (GO:0035871)3.19647085
49cytokine production involved in immune response (GO:0002367)3.19411047
50monoubiquitinated protein deubiquitination (GO:0035520)3.18083080
51replication fork processing (GO:0031297)3.16977487
52regulation of gamma-delta T cell differentiation (GO:0045586)3.15501767
53regulation of interleukin-12 biosynthetic process (GO:0045075)3.13024261
54activated T cell proliferation (GO:0050798)3.11450401
55positive regulation of cell killing (GO:0031343)3.09742214
56regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.09055891
57L-fucose catabolic process (GO:0042355)3.05441716
58fucose catabolic process (GO:0019317)3.05441716
59L-fucose metabolic process (GO:0042354)3.05441716
60positive regulation of granulocyte differentiation (GO:0030854)3.03294894
61positive regulation of cytokine production involved in immune response (GO:0002720)3.03127725
62negative regulation of immunoglobulin mediated immune response (GO:0002890)2.99891298
63negative regulation of B cell mediated immunity (GO:0002713)2.99891298
64T cell lineage commitment (GO:0002360)2.98742601
65Peyers patch development (GO:0048541)2.98304036
66mucosal-associated lymphoid tissue development (GO:0048537)2.98304036
67CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.96798485
68response to protozoan (GO:0001562)2.96189239
69negative regulation of lymphocyte mediated immunity (GO:0002707)2.95617588
70positive regulation of developmental pigmentation (GO:0048087)2.88564866
71positive regulation of cytokine biosynthetic process (GO:0042108)2.88002484
72regulation of gamma-delta T cell activation (GO:0046643)2.87552288
73natural killer cell differentiation (GO:0001779)2.87415669
74cytokine biosynthetic process (GO:0042089)2.86122086
75positive regulation of tyrosine phosphorylation of Stat3 protein (GO:0042517)2.85933714
76T cell mediated immunity (GO:0002456)2.85081952
77positive regulation of B cell activation (GO:0050871)2.84997120
78positive regulation of isotype switching (GO:0045830)2.83434588
79regulation of B cell activation (GO:0050864)2.83037130
80regulation of DNA damage checkpoint (GO:2000001)2.81430544
81negative regulation of B cell activation (GO:0050869)2.78721503
82necroptotic process (GO:0070266)2.78467965
83regulation of B cell differentiation (GO:0045577)2.76342386
84regulation of isotype switching (GO:0045191)2.75470719
85double-strand break repair via homologous recombination (GO:0000724)2.73275721
86recombinational repair (GO:0000725)2.72891278
87viral mRNA export from host cell nucleus (GO:0046784)2.72764875
88peptidyl-lysine trimethylation (GO:0018023)2.72641373
89lactate metabolic process (GO:0006089)2.69881101
90positive regulation of lymphocyte differentiation (GO:0045621)2.67789053
91regulation of lymphocyte mediated immunity (GO:0002706)2.66644138
92positive regulation of lymphocyte mediated immunity (GO:0002708)2.66035491
93negative regulation of alpha-beta T cell activation (GO:0046636)2.65828323
94alpha-beta T cell differentiation (GO:0046632)2.64940675
95positive regulation of tyrosine phosphorylation of STAT protein (GO:0042531)2.63769991
96CD4-positive, alpha-beta T cell activation (GO:0035710)2.62992607
97regulation of B cell receptor signaling pathway (GO:0050855)2.62759241
98positive regulation of tissue remodeling (GO:0034105)2.62692695
99establishment of protein localization to Golgi (GO:0072600)2.62143615
100positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.62123500

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.61841765
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.47508972
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.12275313
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.88001439
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.36211021
6NOTCH1_21737748_ChIP-Seq_TLL_Human2.91775748
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.71695872
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.69412031
9CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.47663090
10VDR_22108803_ChIP-Seq_LS180_Human2.39846533
11IGF1R_20145208_ChIP-Seq_DFB_Human2.33545287
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.31627843
13TAF15_26573619_Chip-Seq_HEK293_Human2.20513696
14RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.19960731
15ZNF274_21170338_ChIP-Seq_K562_Hela2.15975721
16RUNX_20019798_ChIP-Seq_JUKART_Human2.10583848
17SMAD_19615063_ChIP-ChIP_OVARY_Human2.09819968
18GBX2_23144817_ChIP-Seq_PC3_Human2.04725952
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.96595298
20IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.94437291
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.85807592
22IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.82631276
23FLI1_27457419_Chip-Seq_LIVER_Mouse1.82386933
24ZFP57_27257070_Chip-Seq_ESCs_Mouse1.81813669
25MYB_26560356_Chip-Seq_TH2_Human1.80907341
26IRF8_21731497_ChIP-ChIP_J774_Mouse1.78472423
27EWS_26573619_Chip-Seq_HEK293_Human1.77585289
28BP1_19119308_ChIP-ChIP_Hs578T_Human1.72676466
29TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72195207
30UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.64424822
31GATA3_26560356_Chip-Seq_TH2_Human1.62991402
32ER_23166858_ChIP-Seq_MCF-7_Human1.61083199
33FUS_26573619_Chip-Seq_HEK293_Human1.56773213
34AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.54512243
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.54177457
36GATA1_22025678_ChIP-Seq_K562_Human1.52132441
37P300_19829295_ChIP-Seq_ESCs_Human1.49350819
38GATA3_27048872_Chip-Seq_THYMUS_Human1.48847296
39SCL_19346495_ChIP-Seq_HPC-7_Human1.42256716
40ELK1_19687146_ChIP-ChIP_HELA_Human1.40872650
41VDR_23849224_ChIP-Seq_CD4+_Human1.38257407
42GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.37941756
43RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.37447524
44STAT3_23295773_ChIP-Seq_U87_Human1.36978713
45PCGF2_27294783_Chip-Seq_NPCs_Mouse1.36701123
46PCGF2_27294783_Chip-Seq_ESCs_Mouse1.36510179
47TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33097424
48POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.33097424
49PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.31858657
50IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.30441579
51CBP_20019798_ChIP-Seq_JUKART_Human1.30441579
52MYB_26560356_Chip-Seq_TH1_Human1.30409770
53TCF4_23295773_ChIP-Seq_U87_Human1.29190614
54BCAT_22108803_ChIP-Seq_LS180_Human1.23304045
55PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.23249687
56PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21320463
57SMAD4_21799915_ChIP-Seq_A2780_Human1.19592853
58PADI4_21655091_ChIP-ChIP_MCF-7_Human1.19320652
59TP53_22573176_ChIP-Seq_HFKS_Human1.19239966
60MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.17006816
61Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.16411815
62EZH2_27294783_Chip-Seq_NPCs_Mouse1.16096543
63SUZ12_27294783_Chip-Seq_NPCs_Mouse1.15615785
64TCF4_22108803_ChIP-Seq_LS180_Human1.13785033
65IRF8_27001747_Chip-Seq_BMDM_Mouse1.13607974
66CTBP2_25329375_ChIP-Seq_LNCAP_Human1.13474459
67MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.12844491
68STAT4_19710469_ChIP-ChIP_TH1__Mouse1.11500299
69PRDM14_20953172_ChIP-Seq_ESCs_Human1.11088433
70PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09656498
71FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.07910314
72CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06085532
73VDR_24787735_ChIP-Seq_THP-1_Human1.05418223
74TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04400080
75FLI1_21867929_ChIP-Seq_TH2_Mouse1.03012206
76OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02339726
77EST1_17652178_ChIP-ChIP_JURKAT_Human1.02149308
78NFE2_27457419_Chip-Seq_LIVER_Mouse1.01766256
79IRF1_19129219_ChIP-ChIP_H3396_Human1.00148707
80EGR1_23403033_ChIP-Seq_LIVER_Mouse0.99807740
81NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98864886
82GABP_17652178_ChIP-ChIP_JURKAT_Human0.98137726
83CTBP1_25329375_ChIP-Seq_LNCAP_Human0.97986582
84TP53_16413492_ChIP-PET_HCT116_Human0.97435296
85E2F4_17652178_ChIP-ChIP_JURKAT_Human0.97201421
86FOXA1_21572438_ChIP-Seq_LNCaP_Human0.96960251
87SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96626099
88TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95379925
89EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.94479846
90KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.94198779
91CRX_20693478_ChIP-Seq_RETINA_Mouse0.94135590
92MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.91571837
93MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.90790589
94RUNX2_22187159_ChIP-Seq_PCA_Human0.90751076
95KLF5_20875108_ChIP-Seq_MESCs_Mouse0.90278799
96OCT4_21477851_ChIP-Seq_ESCs_Mouse0.90009730
97E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.89708735
98NANOG_18555785_Chip-Seq_ESCs_Mouse0.89064863
99SUZ12_18555785_Chip-Seq_ESCs_Mouse0.87540090
100E2F1_18555785_Chip-Seq_ESCs_Mouse0.87319286

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation5.84752433
2MP0008057_abnormal_DNA_replication3.88148504
3MP0001835_abnormal_antigen_presentation3.65229857
4MP0003646_muscle_fatigue3.24006239
5MP0003763_abnormal_thymus_physiology3.22974377
6MP0001873_stomach_inflammation3.03971272
7MP0005671_abnormal_response_to2.42907200
8MP0004381_abnormal_hair_follicle2.31842110
9MP0004742_abnormal_vestibular_system2.28131003
10MP0001800_abnormal_humoral_immune2.27070629
11MP0001348_abnormal_lacrimal_gland2.25789672
12MP0005075_abnormal_melanosome_morpholog2.20856660
13MP0002102_abnormal_ear_morphology2.15278477
14MP0005310_abnormal_salivary_gland2.12584607
15MP0000015_abnormal_ear_pigmentation2.05516363
16MP0005387_immune_system_phenotype2.00068548
17MP0001790_abnormal_immune_system2.00068548
18MP0003045_fibrosis1.90281848
19MP0005000_abnormal_immune_tolerance1.88371110
20MP0008877_abnormal_DNA_methylation1.87013989
21MP0000372_irregular_coat_pigmentation1.84891923
22MP0002166_altered_tumor_susceptibility1.82377263
23MP0005174_abnormal_tail_pigmentation1.79847699
24MP0002420_abnormal_adaptive_immunity1.72146467
25MP0002009_preneoplasia1.71381660
26MP0002723_abnormal_immune_serum1.70495840
27MP0002452_abnormal_antigen_presenting1.69725684
28MP0006082_CNS_inflammation1.66292324
29MP0003724_increased_susceptibility_to1.62036347
30MP0008872_abnormal_physiological_respon1.61584623
31MP0000689_abnormal_spleen_morphology1.60517402
32MP0001819_abnormal_immune_cell1.57652230
33MP0002398_abnormal_bone_marrow1.56096412
34MP0000465_gastrointestinal_hemorrhage1.55888993
35MP0004145_abnormal_muscle_electrophysio1.43670323
36MP0002138_abnormal_hepatobiliary_system1.42176137
37MP0000716_abnormal_immune_system1.31492431
38MP0002006_tumorigenesis1.31106049
39MP0008995_early_reproductive_senescence1.30923992
40MP0003787_abnormal_imprinting1.30702559
41MP0000685_abnormal_immune_system1.28976835
42MP0000703_abnormal_thymus_morphology1.26604084
43MP0002722_abnormal_immune_system1.25691816
44MP0001986_abnormal_taste_sensitivity1.24693542
45MP0003786_premature_aging1.17731185
46MP0000371_diluted_coat_color1.17399464
47MP0010155_abnormal_intestine_physiology1.15643562
48MP0002419_abnormal_innate_immunity1.15033434
49MP0008058_abnormal_DNA_repair1.13941594
50MP0003866_abnormal_defecation1.11597428
51MP0001984_abnormal_olfaction1.11008450
52MP0002405_respiratory_system_inflammati1.10029809
53MP0000383_abnormal_hair_follicle1.05516322
54MP0001501_abnormal_sleep_pattern1.04542122
55MP0003221_abnormal_cardiomyocyte_apopto1.04069881
56MP0009785_altered_susceptibility_to1.03159528
57MP0004484_altered_response_of1.00385818
58MP0002332_abnormal_exercise_endurance1.00023161
59MP0005408_hypopigmentation1.00011833
60MP0002429_abnormal_blood_cell0.98618264
61MP0003943_abnormal_hepatobiliary_system0.98256345
62MP0000427_abnormal_hair_cycle0.98088747
63MP0005645_abnormal_hypothalamus_physiol0.97951464
64MP0005025_abnormal_response_to0.97525955
65MP0003950_abnormal_plasma_membrane0.96597575
66MP0001845_abnormal_inflammatory_respons0.92258275
67MP0002148_abnormal_hypersensitivity_rea0.90151279
68MP0009333_abnormal_splenocyte_physiolog0.88868051
69MP0002095_abnormal_skin_pigmentation0.88585381
70MP0002396_abnormal_hematopoietic_system0.88485892
71MP0005167_abnormal_blood-brain_barrier0.86597192
72MP0005647_abnormal_sex_gland0.86025338
73MP0003252_abnormal_bile_duct0.84241526
74MP0002928_abnormal_bile_duct0.80926391
75MP0005464_abnormal_platelet_physiology0.79871871
76MP0004142_abnormal_muscle_tone0.79702734
77MP0001968_abnormal_touch/_nociception0.78399846
78MP0004036_abnormal_muscle_relaxation0.77093505
79MP0004808_abnormal_hematopoietic_stem0.76238636
80MP0001919_abnormal_reproductive_system0.76024438
81MP0008004_abnormal_stomach_pH0.75809512
82MP0002168_other_aberrant_phenotype0.74258570
83MP0009764_decreased_sensitivity_to0.73661616
84MP0010094_abnormal_chromosome_stability0.72231329
85MP0001243_abnormal_dermal_layer0.70215056
86MP0005389_reproductive_system_phenotype0.69416406
87MP0002019_abnormal_tumor_incidence0.69143765
88MP0010307_abnormal_tumor_latency0.67976157
89MP0003436_decreased_susceptibility_to0.67849035
90MP0002736_abnormal_nociception_after0.67228729
91MP0003567_abnormal_fetal_cardiomyocyte0.63998252
92MP0003195_calcinosis0.63607936
93MP0005551_abnormal_eye_electrophysiolog0.62553034
94MP0005266_abnormal_metabolism0.62222660
95MP0002254_reproductive_system_inflammat0.58218605
96MP0008469_abnormal_protein_level0.58036973
97MP0003890_abnormal_embryonic-extraembry0.57697756
98MP0001929_abnormal_gametogenesis0.57368460
99MP0005253_abnormal_eye_physiology0.56792978
100MP0001502_abnormal_circadian_rhythm0.56486965

Predicted human phenotypes

RankGene SetZ-score
1Chronic diarrhea (HP:0002028)7.09859222
2T lymphocytopenia (HP:0005403)5.06654510
3Inflammation of the large intestine (HP:0002037)5.03281902
4Abnormality of T cell number (HP:0011839)4.76241809
5Thyroiditis (HP:0100646)4.52144975
6Gastrointestinal inflammation (HP:0004386)4.48307596
7Severe combined immunodeficiency (HP:0004430)3.96190041
8Abnormality of incisor morphology (HP:0011063)3.31425481
9Abnormality of T cells (HP:0002843)3.19681635
10Abnormality of eosinophils (HP:0001879)3.10255430
11Combined immunodeficiency (HP:0005387)3.08563655
12Volvulus (HP:0002580)2.93208968
13Abnormality of B cell number (HP:0010975)2.83483655
14Bilateral sensorineural hearing impairment (HP:0008619)2.80560278
15Abnormal delayed hypersensitivity skin test (HP:0002963)2.78462597
16B lymphocytopenia (HP:0010976)2.74191759
17Stomatitis (HP:0010280)2.67722987
18Tubulointerstitial nephritis (HP:0001970)2.66770650
19Chromosomal breakage induced by crosslinking agents (HP:0003221)2.65953190
20Chromsome breakage (HP:0040012)2.59547746
21Gaze-evoked nystagmus (HP:0000640)2.58364033
22Pancreatic cysts (HP:0001737)2.50843165
23Progressive inability to walk (HP:0002505)2.50382412
24Acute myeloid leukemia (HP:0004808)2.49756690
25Megalencephaly (HP:0001355)2.49251108
26IgG deficiency (HP:0004315)2.48593748
27Leukocytosis (HP:0001974)2.46690328
28Fair hair (HP:0002286)2.45204069
29Chronic mucocutaneous candidiasis (HP:0002728)2.44976107
30Recurrent cutaneous fungal infections (HP:0011370)2.44976107
31Abnormality of the prostate (HP:0008775)2.43331499
32IgA deficiency (HP:0002720)2.34612784
33Fatigue (HP:0012378)2.29675637
34Autoimmune hemolytic anemia (HP:0001890)2.28101220
35Recurrent fungal infections (HP:0002841)2.25922054
36Abnormality of the renal cortex (HP:0011035)2.25229026
37Genetic anticipation (HP:0003743)2.24504006
38Curly hair (HP:0002212)2.20930888
39Prostate neoplasm (HP:0100787)2.20569561
40Long clavicles (HP:0000890)2.18798991
41Abnormality of DNA repair (HP:0003254)2.16315905
42Clumsiness (HP:0002312)2.14853856
43Myelodysplasia (HP:0002863)2.13215105
44Stomach cancer (HP:0012126)2.11102382
45Abnormality of the renal medulla (HP:0100957)2.09756954
46Duplicated collecting system (HP:0000081)2.09481287
47Eosinophilia (HP:0001880)2.09418639
48Generalized hypopigmentation of hair (HP:0011358)2.06935382
49Mediastinal lymphadenopathy (HP:0100721)2.06035949
50Panhypogammaglobulinemia (HP:0003139)2.05716031
51Abnormality of the renal collecting system (HP:0004742)2.02115224
52Tented upper lip vermilion (HP:0010804)2.02009250
53Abnormality of T cell physiology (HP:0011840)2.00373688
54Abnormality of chromosome stability (HP:0003220)2.00201786
55Clubbing of toes (HP:0100760)1.99366170
56Neoplasm of the tracheobronchial system (HP:0100552)1.96858527
57Aplasia/Hypoplasia of the tibia (HP:0005772)1.96445515
58IgM deficiency (HP:0002850)1.96063006
59Recurrent viral infections (HP:0004429)1.94888860
60Progressive cerebellar ataxia (HP:0002073)1.90807233
61Renal cortical cysts (HP:0000803)1.88376061
62Prominent nose (HP:0000448)1.86729248
63Febrile seizures (HP:0002373)1.86669315
64Recurrent bacterial skin infections (HP:0005406)1.86157969
65Colitis (HP:0002583)1.85860727
66Enlarged kidneys (HP:0000105)1.85752118
67Cystic hygroma (HP:0000476)1.85547615
68Pulmonary infiltrates (HP:0002113)1.84802783
69Papillary thyroid carcinoma (HP:0002895)1.84115480
70Inability to walk (HP:0002540)1.83111099
71Spinal muscular atrophy (HP:0007269)1.81633835
72Rhabdomyosarcoma (HP:0002859)1.80409804
73Abnormality of the incisor (HP:0000676)1.79897938
74Nephronophthisis (HP:0000090)1.79152584
75Aplasia/Hypoplasia of the uvula (HP:0010293)1.78369607
76Protruding tongue (HP:0010808)1.77277158
77Chronic hepatic failure (HP:0100626)1.75660894
78Alveolar cell carcinoma (HP:0006519)1.73856295
79Gingival bleeding (HP:0000225)1.73741652
80Widely spaced teeth (HP:0000687)1.70910366
81Pancreatic fibrosis (HP:0100732)1.69560305
82Neoplasm of striated muscle (HP:0009728)1.69301473
83Abolished electroretinogram (ERG) (HP:0000550)1.69031427
84Hypoplastic iliac wings (HP:0002866)1.68399816
85Carpal bone hypoplasia (HP:0001498)1.66738590
86Astrocytoma (HP:0009592)1.66245528
87Abnormality of the astrocytes (HP:0100707)1.66245528
88Anhidrosis (HP:0000970)1.66202831
89Abnormality of the ileum (HP:0001549)1.65561301
90Submucous cleft hard palate (HP:0000176)1.64866143
91Cupped ear (HP:0000378)1.64667550
92Granulocytopenia (HP:0001913)1.64285030
93Chest pain (HP:0100749)1.63028889
94Adactyly (HP:0009776)1.62694556
95Intestinal atresia (HP:0011100)1.62630193
96Hypoplasia of the thymus (HP:0000778)1.59598903
97Short 1st metacarpal (HP:0010034)1.57896990
98Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.57896990
99Abnormality of male internal genitalia (HP:0000022)1.57776870
100Hypoproteinemia (HP:0003075)1.56981880

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B4.47776817
2FRK3.73118449
3EIF2AK32.74751949
4TXK2.68330867
5BRD42.40128878
6TAOK32.39904341
7BMPR1B2.24608818
8MAP4K22.15710668
9KSR11.95474800
10SCYL21.81667006
11TEC1.79805062
12NLK1.77621373
13PAK31.70878353
14PAK61.68875421
15BMPR21.68640456
16STK391.60126204
17JAK11.54739399
18MARK31.50875827
19TRIM281.49822294
20AKT31.47131479
21PRKAA21.47089843
22RAF11.45891031
23KSR21.38657971
24TNK21.36667502
25NUAK11.36234706
26MAPK131.31355601
27MST41.31092999
28SGK21.30468473
29ZAK1.29633768
30ITK1.25941260
31OXSR11.19532061
32MKNK21.19457691
33MAP3K41.18944871
34BTK1.14791936
35PIK3CG1.13697784
36TYK21.13031195
37CLK11.12509479
38WNK41.11841091
39IKBKE1.10830130
40JAK31.08133364
41OBSCN1.06171348
42IKBKB0.99988313
43JAK20.97270375
44BLK0.95427890
45BCR0.93606005
46SRPK10.92465362
47HCK0.92287856
48TRPM70.92255515
49WNK30.91652984
50TLK10.91002158
51SYK0.89315895
52MAP3K140.88522381
53CSNK1A1L0.87156296
54CSNK1G10.86428981
55EIF2AK10.85703334
56ADRBK20.82403541
57LCK0.80217154
58ZAP700.78754815
59FES0.74727989
60ERBB30.72062737
61IRAK10.69613390
62SGK10.68916465
63LYN0.68119150
64SGK4940.67695295
65SGK2230.67695295
66CHUK0.67548120
67MAP4K10.65768393
68FLT30.64167029
69PIM10.62540425
70MAPK110.62454922
71PRKCQ0.59938607
72WNK10.59090147
73DYRK1A0.58141406
74EIF2AK20.57026087
75KIT0.55459270
76SGK30.55169770
77EPHA30.53155858
78ATR0.50196434
79EGFR0.49073698
80PINK10.48837234
81GRK70.48013652
82PLK40.47814500
83TNIK0.47561311
84SIK30.44670500
85ATM0.44153564
86CSNK1D0.43928050
87MAP2K10.43737315
88GRK60.43315783
89MAP2K70.41713313
90PIK3CA0.41601958
91MKNK10.41201349
92FER0.41099941
93RPS6KA50.40596700
94CAMK40.40165398
95ABL10.40066649
96ERBB20.37658513
97STK38L0.37341127
98PLK20.32347246
99IGF1R0.32084012
100INSRR0.31403882

Predicted pathways (KEGG)

RankGene SetZ-score
1Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.68860750
2Primary immunodeficiency_Homo sapiens_hsa053403.25469576
3Asthma_Homo sapiens_hsa053102.86689032
4Allograft rejection_Homo sapiens_hsa053302.83043383
5Jak-STAT signaling pathway_Homo sapiens_hsa046302.80051461
6Autoimmune thyroid disease_Homo sapiens_hsa053202.71186889
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.35404364
8T cell receptor signaling pathway_Homo sapiens_hsa046602.28185892
9Hematopoietic cell lineage_Homo sapiens_hsa046402.16656110
10Graft-versus-host disease_Homo sapiens_hsa053322.09462403
11Fanconi anemia pathway_Homo sapiens_hsa034602.02032607
12Measles_Homo sapiens_hsa051621.94082733
13NF-kappa B signaling pathway_Homo sapiens_hsa040641.91159331
14Homologous recombination_Homo sapiens_hsa034401.75659334
15Systemic lupus erythematosus_Homo sapiens_hsa053221.65931821
16Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.55381923
17Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.49705329
18NOD-like receptor signaling pathway_Homo sapiens_hsa046211.49155857
19Transcriptional misregulation in cancer_Homo sapiens_hsa052021.47752982
20Type I diabetes mellitus_Homo sapiens_hsa049401.45297480
21Leishmaniasis_Homo sapiens_hsa051401.44448224
22Non-homologous end-joining_Homo sapiens_hsa034501.42565426
23Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.40303045
24Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.34684565
25p53 signaling pathway_Homo sapiens_hsa041151.32566114
26Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.31059801
27Nitrogen metabolism_Homo sapiens_hsa009101.30427229
28RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.29114746
29Regulation of autophagy_Homo sapiens_hsa041401.28428933
30B cell receptor signaling pathway_Homo sapiens_hsa046621.20681767
31Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.20213240
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.17852875
33Dorso-ventral axis formation_Homo sapiens_hsa043201.16218125
34Legionellosis_Homo sapiens_hsa051341.13936420
35Herpes simplex infection_Homo sapiens_hsa051681.13788618
36Antigen processing and presentation_Homo sapiens_hsa046121.09294839
37Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.07569263
38Basal transcription factors_Homo sapiens_hsa030221.05303941
39Prolactin signaling pathway_Homo sapiens_hsa049171.04705696
40RNA transport_Homo sapiens_hsa030131.04264326
41Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.02491971
42FoxO signaling pathway_Homo sapiens_hsa040681.01252597
43TNF signaling pathway_Homo sapiens_hsa046680.98507808
44Phototransduction_Homo sapiens_hsa047440.98454462
45Influenza A_Homo sapiens_hsa051640.90929386
46Viral myocarditis_Homo sapiens_hsa054160.89390846
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.87851937
48Taste transduction_Homo sapiens_hsa047420.85339286
49Tuberculosis_Homo sapiens_hsa051520.84706373
50Osteoclast differentiation_Homo sapiens_hsa043800.84049837
51Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.83895871
52ABC transporters_Homo sapiens_hsa020100.81086038
53alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.80038387
54Toxoplasmosis_Homo sapiens_hsa051450.79528998
55Hepatitis B_Homo sapiens_hsa051610.77564789
56Olfactory transduction_Homo sapiens_hsa047400.77398143
57Platelet activation_Homo sapiens_hsa046110.73606125
58Alcoholism_Homo sapiens_hsa050340.72348567
59Lysine degradation_Homo sapiens_hsa003100.72329991
60Apoptosis_Homo sapiens_hsa042100.72118789
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.69363105
62Circadian rhythm_Homo sapiens_hsa047100.69006311
63Viral carcinogenesis_Homo sapiens_hsa052030.68317209
64Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67097001
65mRNA surveillance pathway_Homo sapiens_hsa030150.65486426
66RNA degradation_Homo sapiens_hsa030180.64004755
67Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.61405275
68Rheumatoid arthritis_Homo sapiens_hsa053230.59744543
69Acute myeloid leukemia_Homo sapiens_hsa052210.58430543
70Toll-like receptor signaling pathway_Homo sapiens_hsa046200.56194491
71Staphylococcus aureus infection_Homo sapiens_hsa051500.55824534
72Colorectal cancer_Homo sapiens_hsa052100.53495256
73Fatty acid biosynthesis_Homo sapiens_hsa000610.53439406
74Inositol phosphate metabolism_Homo sapiens_hsa005620.53237718
75RNA polymerase_Homo sapiens_hsa030200.53084059
76Linoleic acid metabolism_Homo sapiens_hsa005910.50069156
77Chemokine signaling pathway_Homo sapiens_hsa040620.49655627
78Non-small cell lung cancer_Homo sapiens_hsa052230.49319114
79Insulin resistance_Homo sapiens_hsa049310.48709738
80MicroRNAs in cancer_Homo sapiens_hsa052060.44055695
81HTLV-I infection_Homo sapiens_hsa051660.38468260
82Epstein-Barr virus infection_Homo sapiens_hsa051690.35607437
83Propanoate metabolism_Homo sapiens_hsa006400.35596833
84Prostate cancer_Homo sapiens_hsa052150.35386462
85Sphingolipid signaling pathway_Homo sapiens_hsa040710.34872929
86Calcium signaling pathway_Homo sapiens_hsa040200.33955782
87SNARE interactions in vesicular transport_Homo sapiens_hsa041300.33625608
88Ether lipid metabolism_Homo sapiens_hsa005650.32959463
89ErbB signaling pathway_Homo sapiens_hsa040120.32850903
90Choline metabolism in cancer_Homo sapiens_hsa052310.30616922
91Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.30432046
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.30093186
93Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.29493072
94Hepatitis C_Homo sapiens_hsa051600.28447146
95Cell cycle_Homo sapiens_hsa041100.28090595
96Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.27879912
97Serotonergic synapse_Homo sapiens_hsa047260.27411573
98African trypanosomiasis_Homo sapiens_hsa051430.27266320
99Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.27090826
100Oocyte meiosis_Homo sapiens_hsa041140.26399869

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