ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	monoubiquitinated protein deubiquitination (GO:0035520)	6.50359951
2	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	5.49627431
3	negative regulation of translation, ncRNA-mediated (GO:0040033)	5.49627431
4	regulation of translation, ncRNA-mediated (GO:0045974)	5.49627431
5	histone H3-K4 trimethylation (GO:0080182)	4.89269893
6	histone H3-K9 methylation (GO:0051567)	4.34926264
7	interkinetic nuclear migration (GO:0022027)	4.33691261
8	snRNA transcription (GO:0009301)	4.27141585
9	histone H3-K9 modification (GO:0061647)	4.17140544
10	pre-miRNA processing (GO:0031054)	4.14515463
11	peptidyl-lysine trimethylation (GO:0018023)	4.10267400
12	positive regulation of developmental pigmentation (GO:0048087)	4.08779968
13	peptidyl-lysine methylation (GO:0018022)	4.05140467
14	protein K48-linked deubiquitination (GO:0071108)	4.04240916
15	phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)	3.80967660
16	activated T cell proliferation (GO:0050798)	3.75423323
17	histone H3-K36 demethylation (GO:0070544)	3.66855349
18	regulation of pigment cell differentiation (GO:0050932)	3.65531451
19	regulation of hippo signaling (GO:0035330)	3.55144333
20	cellular response to ethanol (GO:0071361)	3.41943613
21	regulation of establishment of cell polarity (GO:2000114)	3.39114668
22	histone lysine methylation (GO:0034968)	3.33616854
23	histone H3-K4 methylation (GO:0051568)	3.32756690
24	positive regulation of granulocyte differentiation (GO:0030854)	3.29330295
25	protein K63-linked deubiquitination (GO:0070536)	3.15489316
26	positive regulation of CREB transcription factor activity (GO:0032793)	3.08780336
27	cornea development in camera-type eye (GO:0061303)	3.03892498
28	establishment of protein localization to Golgi (GO:0072600)	3.00603648
29	glucocorticoid receptor signaling pathway (GO:0042921)	2.97570684
30	protein K11-linked deubiquitination (GO:0035871)	2.95537120
31	regulation of DNA endoreduplication (GO:0032875)	2.95134475
32	phospholipid translocation (GO:0045332)	2.94834507
33	lipid translocation (GO:0034204)	2.94834507
34	regulation of gamma-delta T cell differentiation (GO:0045586)	2.92364847
35	regulation of interleukin-12 biosynthetic process (GO:0045075)	2.91016344
36	mannose metabolic process (GO:0006013)	2.90223177
37	regulation of B cell receptor signaling pathway (GO:0050855)	2.86696844
38	peptidyl-threonine dephosphorylation (GO:0035970)	2.84092946
39	regulation of posttranscriptional gene silencing (GO:0060147)	2.83745563
40	regulation of gene silencing by miRNA (GO:0060964)	2.83745563
41	regulation of gene silencing by RNA (GO:0060966)	2.83745563
42	regulation of establishment or maintenance of cell polarity (GO:0032878)	2.81041890
43	replicative senescence (GO:0090399)	2.79724800
44	TOR signaling (GO:0031929)	2.77149606
45	regulation of MHC class I biosynthetic process (GO:0045343)	2.72593293
46	cytoplasmic mRNA processing body assembly (GO:0033962)	2.71752218
47	corticosteroid receptor signaling pathway (GO:0031958)	2.70984744
48	neural tube formation (GO:0001841)	2.66252107
49	regulation of gamma-delta T cell activation (GO:0046643)	2.65741915
50	hepatocyte apoptotic process (GO:0097284)	2.60764921
51	mitotic sister chromatid cohesion (GO:0007064)	2.59510972
52	negative regulation of dendrite morphogenesis (GO:0050774)	2.57447991
53	histone methylation (GO:0016571)	2.55289341
54	NAD biosynthetic process (GO:0009435)	2.54711236
55	regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)	2.51941533
56	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)	2.51941533
57	positive regulation of protein deacetylation (GO:0090312)	2.50732640
58	T cell mediated immunity (GO:0002456)	2.48295309
59	tachykinin receptor signaling pathway (GO:0007217)	2.46730020
60	microtubule depolymerization (GO:0007019)	2.45161954
61	phosphatidylinositol phosphorylation (GO:0046854)	2.43853285
62	mRNA cleavage (GO:0006379)	2.43404510
63	regulation of histone H3-K27 methylation (GO:0061085)	2.42654910
64	microtubule anchoring (GO:0034453)	2.42591149
65	regulation of sarcomere organization (GO:0060297)	2.42497951
66	positive regulation of histone deacetylation (GO:0031065)	2.42362779
67	positive T cell selection (GO:0043368)	2.42252694
68	cAMP catabolic process (GO:0006198)	2.41558628
69	membrane depolarization during action potential (GO:0086010)	2.41015426
70	B cell receptor signaling pathway (GO:0050853)	2.40980870
71	positive regulation of mRNA catabolic process (GO:0061014)	2.40561269
72	rRNA catabolic process (GO:0016075)	2.39594188
73	histone lysine demethylation (GO:0070076)	2.37305237
74	negative regulation of Rho protein signal transduction (GO:0035024)	2.37048715
75	gene silencing by RNA (GO:0031047)	2.36319963
76	positive regulation of transcription from RNA polymerase III promoter (GO:0045945)	2.35828653
77	histone demethylation (GO:0016577)	2.35278594
78	chromatin silencing (GO:0006342)	2.33183324
79	regulation of necroptotic process (GO:0060544)	2.32534955
80	striated muscle atrophy (GO:0014891)	2.30014951
81	gene silencing (GO:0016458)	2.29029718
82	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.28757639
83	embryonic camera-type eye morphogenesis (GO:0048596)	2.27696519
84	sister chromatid cohesion (GO:0007062)	2.27220818
85	nucleus localization (GO:0051647)	2.27003930
86	fucose catabolic process (GO:0019317)	2.26521205
87	L-fucose metabolic process (GO:0042354)	2.26521205
88	L-fucose catabolic process (GO:0042355)	2.26521205
89	DNA methylation (GO:0006306)	2.25750756
90	DNA alkylation (GO:0006305)	2.25750756
91	lipid phosphorylation (GO:0046834)	2.25169472
92	interferon-gamma production (GO:0032609)	2.25126375
93	indolalkylamine metabolic process (GO:0006586)	2.25114717
94	regulation of female gonad development (GO:2000194)	2.24299732
95	regulation of granulocyte differentiation (GO:0030852)	2.22660639
96	positive regulation of gene expression, epigenetic (GO:0045815)	2.22367990
97	regulation of mRNA catabolic process (GO:0061013)	2.21147163
98	mature B cell differentiation (GO:0002335)	2.20845474
99	negative regulation of gene expression, epigenetic (GO:0045814)	2.20751673
100	regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)	2.20666440

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.48112228
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.23440580
3	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.80177919
4	AR_21572438_ChIP-Seq_LNCaP_Human	2.78315992
5	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.52529491
6	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.47961209
7	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.41221679
8	VDR_22108803_ChIP-Seq_LS180_Human	2.37260184
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.32650344
10	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.26559858
11	DROSHA_22980978_ChIP-Seq_HELA_Human	2.23449432
12	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.15112216
13	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	2.13800441
14	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.00366105
15	AHR_22903824_ChIP-Seq_MCF-7_Human	1.99919270
16	GBX2_23144817_ChIP-Seq_PC3_Human	1.93441560
17	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.88483245
18	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.88483245
19	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.87808458
20	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	1.86705876
21	ER_23166858_ChIP-Seq_MCF-7_Human	1.81131365
22	SCL_19346495_ChIP-Seq_HPC-7_Human	1.77786201
23	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.77777314
24	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.75714469
25	STAT3_23295773_ChIP-Seq_U87_Human	1.74290940
26	RUNX_20019798_ChIP-Seq_JUKART_Human	1.70024030
27	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.69622403
28	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.67664993
29	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.67637837
30	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.65002774
31	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.64859324
32	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.62793966
33	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.58169504
34	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.51747640
35	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.50489059
36	TP53_16413492_ChIP-PET_HCT116_Human	1.49920914
37	TCF4_23295773_ChIP-Seq_U87_Human	1.48616842
38	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.37962308
39	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.33175196
40	GATA1_22025678_ChIP-Seq_K562_Human	1.33019860
41	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.28511220
42	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.24401797
43	SMAD4_21799915_ChIP-Seq_A2780_Human	1.24188195
44	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.23684971
45	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.23551259
46	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.23056433
47	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.22713545
48	RXR_22108803_ChIP-Seq_LS180_Human	1.22168350
49	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.21344891
50	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.21269561
51	CBP_20019798_ChIP-Seq_JUKART_Human	1.21269561
52	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.19716740
53	BCAT_22108803_ChIP-Seq_LS180_Human	1.18059645
54	IGF1R_20145208_ChIP-Seq_DFB_Human	1.17474799
55	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.17095059
56	NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human	1.16695514
57	MYB_26560356_Chip-Seq_TH1_Human	1.15664164
58	GATA3_27048872_Chip-Seq_THYMUS_Human	1.14901766
59	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.14809427
60	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.14203497
61	VDR_24787735_ChIP-Seq_THP-1_Human	1.13619030
62	MYC_22102868_ChIP-Seq_BL_Human	1.11901817
63	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.10625698
64	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.10535867
65	STAT3_20064451_ChIP-Seq_CD4+T_Mouse	1.10369224
66	PKCTHETA_26484144_Chip-Seq_BREAST_Human	1.10138213
67	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.09390204
68	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.08954323
69	FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse	1.07074782
70	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.06835638
71	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.05789049
72	P300_19829295_ChIP-Seq_ESCs_Human	1.05723460
73	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.05537205
74	MYB_26560356_Chip-Seq_TH2_Human	1.05310741
75	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.04978551
76	GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.04404542
77	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.04218416
78	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.03921966
79	KDM2B_26808549_Chip-Seq_HPB-ALL_Human	1.02434622
80	TAF15_26573619_Chip-Seq_HEK293_Human	1.01490532
81	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.00812026
82	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.99667469
83	GATA3_26560356_Chip-Seq_TH2_Human	0.99628458
84	AR_19668381_ChIP-Seq_PC3_Human	0.99555217
85	FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human	0.97719627
86	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.96189700
87	FUS_26573619_Chip-Seq_HEK293_Human	0.95892150
88	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.95792702
89	EWS_26573619_Chip-Seq_HEK293_Human	0.93177169
90	TCF4_22108803_ChIP-Seq_LS180_Human	0.91810672
91	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.90420293
92	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.89918400
93	RUNX1_27514584_Chip-Seq_MCF-7_Human	0.89249996
94	REST_21632747_ChIP-Seq_MESCs_Mouse	0.87179046
95	GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.87133739
96	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.86958896
97	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.86922588
98	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	0.86861077
99	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.86302362
100	RUNX2_22187159_ChIP-Seq_PCA_Human	0.84749838

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	6.09690690
2	MP0008057_abnormal_DNA_replication	4.43719446
3	MP0005670_abnormal_white_adipose	4.35143828
4	MP0008961_abnormal_basal_metabolism	3.17035913
5	MP0003183_abnormal_peptide_metabolism	3.03349594
6	MP0001986_abnormal_taste_sensitivity	2.68535257
7	MP0003045_fibrosis	2.57122761
8	MP0003646_muscle_fatigue	2.46449662
9	MP0002638_abnormal_pupillary_reflex	2.40987640
10	MP0005076_abnormal_cell_differentiation	2.36052993
11	MP0003787_abnormal_imprinting	2.24805492
12	MP0004381_abnormal_hair_follicle	2.09191477
13	MP0008877_abnormal_DNA_methylation	2.03164739
14	MP0003763_abnormal_thymus_physiology	1.99526394
15	MP0005174_abnormal_tail_pigmentation	1.94807376
16	MP0000015_abnormal_ear_pigmentation	1.87279909
17	MP0001501_abnormal_sleep_pattern	1.76512052
18	MP0005310_abnormal_salivary_gland	1.67916121
19	MP0002396_abnormal_hematopoietic_system	1.65654081
20	MP0000383_abnormal_hair_follicle	1.61848528
21	MP0000685_abnormal_immune_system	1.53567719
22	MP0001873_stomach_inflammation	1.53316875
23	MP0001800_abnormal_humoral_immune	1.51482674
24	MP0004130_abnormal_muscle_cell	1.48860804
25	MP0003136_yellow_coat_color	1.40606717
26	MP0002735_abnormal_chemical_nociception	1.40277568
27	MP0001835_abnormal_antigen_presentation	1.36052838
28	MP0008872_abnormal_physiological_respon	1.34139324
29	MP0006292_abnormal_olfactory_placode	1.34102416
30	MP0001968_abnormal_touch/_nociception	1.31890427
31	MP0000427_abnormal_hair_cycle	1.29585055
32	MP0010307_abnormal_tumor_latency	1.28159292
33	MP0004808_abnormal_hematopoietic_stem	1.27877112
34	MP0009115_abnormal_fat_cell	1.27526286
35	MP0005451_abnormal_body_composition	1.23659414
36	MP0005423_abnormal_somatic_nervous	1.22405771
37	MP0010094_abnormal_chromosome_stability	1.21367191
38	MP0001502_abnormal_circadian_rhythm	1.16005784
39	MP0000703_abnormal_thymus_morphology	1.11489627
40	MP0002398_abnormal_bone_marrow	1.11303553
41	MP0009046_muscle_twitch	1.10991424
42	MP0005410_abnormal_fertilization	1.09417331
43	MP0002168_other_aberrant_phenotype	1.09196632
44	MP0004043_abnormal_pH_regulation	1.08621601
45	MP0009745_abnormal_behavioral_response	1.04704057
46	MP0000470_abnormal_stomach_morphology	1.04576532
47	MP0002928_abnormal_bile_duct	1.00987055
48	MP0005551_abnormal_eye_electrophysiolog	1.00896064
49	MP0000371_diluted_coat_color	0.98596386
50	MP0004084_abnormal_cardiac_muscle	0.96955633
51	MP0002009_preneoplasia	0.95897622
52	MP0005645_abnormal_hypothalamus_physiol	0.95593653
53	MP0002332_abnormal_exercise_endurance	0.94779316
54	MP0004142_abnormal_muscle_tone	0.94750979
55	MP0005666_abnormal_adipose_tissue	0.93891016
56	MP0005448_abnormal_energy_balance	0.92213855
57	MP0005671_abnormal_response_to	0.91467341
58	MP0008995_early_reproductive_senescence	0.89242674
59	MP0003172_abnormal_lysosome_physiology	0.89156425
60	MP0002420_abnormal_adaptive_immunity	0.88914272
61	MP0002452_abnormal_antigen_presenting	0.88818706
62	MP0001819_abnormal_immune_cell	0.88226856
63	MP0000716_abnormal_immune_system	0.87840735
64	MP0005083_abnormal_biliary_tract	0.87243606
65	MP0005266_abnormal_metabolism	0.85977520
66	MP0004233_abnormal_muscle_weight	0.85599859
67	MP0001486_abnormal_startle_reflex	0.83895042
68	MP0002723_abnormal_immune_serum	0.82982804
69	MP0000689_abnormal_spleen_morphology	0.82621494
70	MP0003698_abnormal_male_reproductive	0.82015479
71	MP0001929_abnormal_gametogenesis	0.81281119
72	MP0001440_abnormal_grooming_behavior	0.80950961
73	MP0002067_abnormal_sensory_capabilities	0.79922980
74	MP0008770_decreased_survivor_rate	0.79405896
75	MP0002722_abnormal_immune_system	0.79380418
76	MP0003077_abnormal_cell_cycle	0.78586064
77	MP0005387_immune_system_phenotype	0.76401256
78	MP0001790_abnormal_immune_system	0.76401256
79	MP0002064_seizures	0.72373085
80	MP0008058_abnormal_DNA_repair	0.71771505
81	MP0004036_abnormal_muscle_relaxation	0.71393179
82	MP0003195_calcinosis	0.71175919
83	MP0003890_abnormal_embryonic-extraembry	0.70628595
84	MP0002970_abnormal_white_adipose	0.69819514
85	MP0001485_abnormal_pinna_reflex	0.68736836
86	MP0002938_white_spotting	0.67175488
87	MP0001348_abnormal_lacrimal_gland	0.66437703
88	MP0003943_abnormal_hepatobiliary_system	0.64039018
89	MP0005334_abnormal_fat_pad	0.63814383
90	MP0002693_abnormal_pancreas_physiology	0.63362821
91	MP0003878_abnormal_ear_physiology	0.62993326
92	MP0005377_hearing/vestibular/ear_phenot	0.62993326
93	MP0001970_abnormal_pain_threshold	0.62592709
94	MP0005647_abnormal_sex_gland	0.62511529
95	MP0002733_abnormal_thermal_nociception	0.62395148
96	MP0003950_abnormal_plasma_membrane	0.61500517
97	MP0003635_abnormal_synaptic_transmissio	0.60040161
98	MP0001545_abnormal_hematopoietic_system	0.59338331
99	MP0005397_hematopoietic_system_phenotyp	0.59338331
100	MP0005220_abnormal_exocrine_pancreas	0.59188706

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Genetic anticipation (HP:0003743)	6.49093680
2	Progressive cerebellar ataxia (HP:0002073)	4.46399697
3	Protruding tongue (HP:0010808)	4.06314903
4	Gaze-evoked nystagmus (HP:0000640)	3.89564061
5	Clumsiness (HP:0002312)	3.76784356
6	Hyperventilation (HP:0002883)	3.62485183
7	Dysmetric saccades (HP:0000641)	3.55261219
8	Febrile seizures (HP:0002373)	3.37951598
9	Abnormality of the fingertips (HP:0001211)	3.31247604
10	Oligodactyly (hands) (HP:0001180)	2.92613622
11	Duplicated collecting system (HP:0000081)	2.87267267
12	Acute lymphatic leukemia (HP:0006721)	2.85113825
13	Fair hair (HP:0002286)	2.84190806
14	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	2.80473737
15	Ectopic kidney (HP:0000086)	2.75069433
16	Impaired smooth pursuit (HP:0007772)	2.73569589
17	Stomach cancer (HP:0012126)	2.70486124
18	Truncal obesity (HP:0001956)	2.69551984
19	Congenital stationary night blindness (HP:0007642)	2.67522576
20	Volvulus (HP:0002580)	2.64520447
21	Urinary bladder sphincter dysfunction (HP:0002839)	2.63844242
22	Abnormality of the renal collecting system (HP:0004742)	2.61060093
23	Prominent nose (HP:0000448)	2.60677722
24	Abnormality of the pons (HP:0007361)	2.53239171
25	Hypoplasia of the pons (HP:0012110)	2.46305145
26	Widely spaced teeth (HP:0000687)	2.44694517
27	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.44209019
28	Chronic hepatic failure (HP:0100626)	2.43761371
29	Chromsome breakage (HP:0040012)	2.40589799
30	Postural instability (HP:0002172)	2.36442301
31	Attenuation of retinal blood vessels (HP:0007843)	2.35363496
32	Hypoplastic nipples (HP:0002557)	2.34958739
33	Supernumerary bones of the axial skeleton (HP:0009144)	2.34905019
34	Patellar aplasia (HP:0006443)	2.34822325
35	Tented upper lip vermilion (HP:0010804)	2.33107540
36	Generalized hypopigmentation of hair (HP:0011358)	2.30803252
37	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.20266668
38	Chronic mucocutaneous candidiasis (HP:0002728)	2.19685154
39	Recurrent cutaneous fungal infections (HP:0011370)	2.19685154
40	Increased neuronal autofluorescent lipopigment (HP:0002074)	2.18929469
41	Long eyelashes (HP:0000527)	2.09248673
42	Hypoplastic ischia (HP:0003175)	2.08366317
43	Cerebellar dysplasia (HP:0007033)	2.08051584
44	Supernumerary ribs (HP:0005815)	2.07916640
45	Hypoplastic iliac wings (HP:0002866)	2.07570320
46	Aplasia/Hypoplasia of the patella (HP:0006498)	2.07008803
47	Abnormality of the labia majora (HP:0012881)	2.05597256
48	Abnormality of DNA repair (HP:0003254)	2.04205041
49	Pancreatic cysts (HP:0001737)	2.04200766
50	Broad-based gait (HP:0002136)	2.03565610
51	Abnormality of binocular vision (HP:0011514)	2.03507028
52	Diplopia (HP:0000651)	2.03507028
53	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.03124532
54	Autoimmune thrombocytopenia (HP:0001973)	2.02516835
55	Abnormality of T cell number (HP:0011839)	2.00852469
56	Sandal gap (HP:0001852)	2.00793216
57	Oligodontia (HP:0000677)	2.00538096
58	Ureteral duplication (HP:0000073)	2.00260983
59	Hypoplastic labia majora (HP:0000059)	1.99651265
60	Amelogenesis imperfecta (HP:0000705)	1.99296324
61	Lip pit (HP:0100267)	1.99292127
62	Absent radius (HP:0003974)	1.99249865
63	Intellectual disability, progressive (HP:0006887)	1.98816926
64	Abnormality of the columella (HP:0009929)	1.98265552
65	Inability to walk (HP:0002540)	1.98086509
66	Abnormality of the ischium (HP:0003174)	1.97306031
67	T lymphocytopenia (HP:0005403)	1.97147879
68	Progressive inability to walk (HP:0002505)	1.94418655
69	Aplasia involving forearm bones (HP:0009822)	1.89240045
70	Absent forearm bone (HP:0003953)	1.89240045
71	Truncal ataxia (HP:0002078)	1.88369321
72	Abnormality of ocular smooth pursuit (HP:0000617)	1.87035730
73	Colitis (HP:0002583)	1.85793445
74	Tapered finger (HP:0001182)	1.84951272
75	Panhypogammaglobulinemia (HP:0003139)	1.84770748
76	Decreased circulating renin level (HP:0003351)	1.84255810
77	Areflexia of lower limbs (HP:0002522)	1.84099807
78	Hypoplasia of the fovea (HP:0007750)	1.82782281
79	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.82782281
80	Polydipsia (HP:0001959)	1.82147630
81	Abnormal drinking behavior (HP:0030082)	1.82147630
82	Low anterior hairline (HP:0000294)	1.81578236
83	Clubbing of toes (HP:0100760)	1.80550453
84	Birth length less than 3rd percentile (HP:0003561)	1.79266079
85	Optic nerve coloboma (HP:0000588)	1.78328215
86	Macroglossia (HP:0000158)	1.77465341
87	Tracheomalacia (HP:0002779)	1.77115265
88	Tubular atrophy (HP:0000092)	1.75984356
89	Stereotypic behavior (HP:0000733)	1.74549529
90	Atonic seizures (HP:0010819)	1.72095868
91	Homocystinuria (HP:0002156)	1.70993483
92	Abnormality of homocysteine metabolism (HP:0010919)	1.70993483
93	Acute myeloid leukemia (HP:0004808)	1.70677483
94	Narrow palate (HP:0000189)	1.69690601
95	Epileptic encephalopathy (HP:0200134)	1.66429781
96	Macular degeneration (HP:0000608)	1.65254719
97	Papilledema (HP:0001085)	1.64935158
98	Abnormality of the renal cortex (HP:0011035)	1.64532206
99	Depressed nasal tip (HP:0000437)	1.64089390
100	Abnormality of T cells (HP:0002843)	1.62964531

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	6.53296163
2	ZAK	3.97098512
3	ACVR1B	3.09456413
4	CDK12	2.68821156
5	TLK1	2.39943529
6	BMPR1B	2.25787145
7	TAOK3	2.18621677
8	SIK2	2.10644803
9	AKT3	2.09890591
10	LATS1	2.08487613
11	BRD4	2.02593653
12	TRIB3	1.63672464
13	CAMK1D	1.63243370
14	MAP2K6	1.57557191
15	PIK3CG	1.56378907
16	TEC	1.55301413
17	MAPK13	1.45922223
18	BMPR2	1.44522841
19	TNK2	1.43795295
20	CAMK1G	1.42138726
21	MARK2	1.41154075
22	INSRR	1.37811486
23	BLK	1.34945664
24	MELK	1.30319732
25	NUAK1	1.20484722
26	OXSR1	1.20003611
27	HIPK2	1.19645367
28	MAP3K4	1.16475986
29	NEK2	1.13246233
30	EEF2K	1.13057390
31	STK39	1.12800745
32	SGK2	1.09301320
33	NTRK3	1.07807744
34	MAP4K1	1.05234830
35	MARK3	1.05138054
36	BTK	1.02577460
37	MKNK2	0.97915319
38	MAP3K7	0.96984278
39	PKN2	0.92814794
40	NLK	0.91404815
41	PTK2B	0.91186768
42	PRKAA2	0.90335817
43	ITK	0.88754166
44	MAP3K10	0.86272522
45	WNK1	0.85908867
46	GRK1	0.84570675
47	WNK4	0.84522890
48	TRPM7	0.83697905
49	ADRBK2	0.81059534
50	MAP2K3	0.79986613
51	STK38	0.79880186
52	CHUK	0.76429407
53	CDC42BPA	0.73866442
54	MTOR	0.72806005
55	MAPK11	0.71335840
56	STK11	0.68877078
57	CAMK4	0.68620165
58	ADRBK1	0.65414630
59	SGK494	0.61913120
60	SGK223	0.61913120
61	TGFBR1	0.60463087
62	PRKAA1	0.59754984
63	FGFR2	0.57875789
64	NEK6	0.57809400
65	PRKCH	0.56478540
66	MAP3K13	0.56408590
67	PKN1	0.56011696
68	HCK	0.55736088
69	SGK1	0.55408652
70	MAPK12	0.55133199
71	BRSK2	0.54632941
72	CHEK2	0.54316838
73	FES	0.53117931
74	PIM1	0.51920317
75	CDK4	0.51125969
76	IKBKB	0.51088993
77	ERBB2	0.50673748
78	RPS6KA6	0.50441287
79	SYK	0.46947459
80	MAP3K11	0.46518955
81	ATR	0.46434719
82	CAMK1	0.46212890
83	CAMKK1	0.46122502
84	RIPK4	0.44921268
85	TAF1	0.43947132
86	OBSCN	0.43162097
87	PDK1	0.41713814
88	SGK3	0.41450768
89	MAPKAPK3	0.40387362
90	TYRO3	0.40209465
91	GSK3B	0.39638524
92	PIK3CA	0.37812028
93	RPS6KB2	0.37675322
94	IRAK1	0.36851852
95	STK3	0.36448285
96	MAPK7	0.36410883
97	CDK3	0.35990487
98	LCK	0.35300077
99	MAPK8	0.34034265
100	CHEK1	0.33912334

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Lysine degradation_Homo sapiens_hsa00310	1.83128931
2	Graft-versus-host disease_Homo sapiens_hsa05332	1.77736892
3	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.71754950
4	Taste transduction_Homo sapiens_hsa04742	1.69023538
5	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.55897757
6	ABC transporters_Homo sapiens_hsa02010	1.55142729
7	Nicotine addiction_Homo sapiens_hsa05033	1.53069728
8	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	1.51409469
9	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	1.45535910
10	Type II diabetes mellitus_Homo sapiens_hsa04930	1.45302844
11	Primary immunodeficiency_Homo sapiens_hsa05340	1.44066014
12	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	1.44016687
13	Morphine addiction_Homo sapiens_hsa05032	1.40019659
14	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.34379807
15	B cell receptor signaling pathway_Homo sapiens_hsa04662	1.28075373
16	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.27165680
17	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.24388017
18	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.24265516
19	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.24131159
20	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.23467599
21	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.17764015
22	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.17056459
23	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.14638173
24	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	1.13682306
25	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	1.12047996
26	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	1.11570478
27	Cholinergic synapse_Homo sapiens_hsa04725	1.11452729
28	Platelet activation_Homo sapiens_hsa04611	1.10300850
29	Inositol phosphate metabolism_Homo sapiens_hsa00562	1.10077876
30	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	1.09635805
31	Calcium signaling pathway_Homo sapiens_hsa04020	1.09400153
32	Glutamatergic synapse_Homo sapiens_hsa04724	1.08134459
33	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.07685190
34	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.07579225
35	Circadian rhythm_Homo sapiens_hsa04710	1.05747938
36	FoxO signaling pathway_Homo sapiens_hsa04068	1.05692607
37	mTOR signaling pathway_Homo sapiens_hsa04150	1.05435540
38	Prolactin signaling pathway_Homo sapiens_hsa04917	1.04394072
39	TNF signaling pathway_Homo sapiens_hsa04668	1.02006679
40	Circadian entrainment_Homo sapiens_hsa04713	1.01940129
41	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.99999898
42	Phototransduction_Homo sapiens_hsa04744	0.99141659
43	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.98669073
44	Olfactory transduction_Homo sapiens_hsa04740	0.98373092
45	Fanconi anemia pathway_Homo sapiens_hsa03460	0.98068296
46	VEGF signaling pathway_Homo sapiens_hsa04370	0.96021110
47	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.94957291
48	Nitrogen metabolism_Homo sapiens_hsa00910	0.94571421
49	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.92378011
50	Selenocompound metabolism_Homo sapiens_hsa00450	0.92360228
51	Choline metabolism in cancer_Homo sapiens_hsa05231	0.92103730
52	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.90962275
53	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.90840962
54	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.88941636
55	Acute myeloid leukemia_Homo sapiens_hsa05221	0.88769602
56	Basal transcription factors_Homo sapiens_hsa03022	0.88152944
57	Insulin resistance_Homo sapiens_hsa04931	0.86321677
58	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.85816350
59	Alcoholism_Homo sapiens_hsa05034	0.84852878
60	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.84332375
61	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.84257194
62	Non-small cell lung cancer_Homo sapiens_hsa05223	0.83300436
63	MAPK signaling pathway_Homo sapiens_hsa04010	0.82819042
64	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.82752131
65	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.82666336
66	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.82105453
67	Linoleic acid metabolism_Homo sapiens_hsa00591	0.81783607
68	Homologous recombination_Homo sapiens_hsa03440	0.81691008
69	Serotonergic synapse_Homo sapiens_hsa04726	0.78259348
70	GnRH signaling pathway_Homo sapiens_hsa04912	0.78171747
71	ErbB signaling pathway_Homo sapiens_hsa04012	0.78078249
72	cAMP signaling pathway_Homo sapiens_hsa04024	0.75601933
73	GABAergic synapse_Homo sapiens_hsa04727	0.73800226
74	Toxoplasmosis_Homo sapiens_hsa05145	0.72574290
75	MicroRNAs in cancer_Homo sapiens_hsa05206	0.72379830
76	Influenza A_Homo sapiens_hsa05164	0.72155210
77	p53 signaling pathway_Homo sapiens_hsa04115	0.71332394
78	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.70934203
79	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.70544420
80	mRNA surveillance pathway_Homo sapiens_hsa03015	0.70149035
81	Tuberculosis_Homo sapiens_hsa05152	0.70057916
82	Osteoclast differentiation_Homo sapiens_hsa04380	0.70027826
83	Colorectal cancer_Homo sapiens_hsa05210	0.68591710
84	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.68291205
85	Viral carcinogenesis_Homo sapiens_hsa05203	0.66756846
86	Measles_Homo sapiens_hsa05162	0.66002270
87	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.64725916
88	Gastric acid secretion_Homo sapiens_hsa04971	0.63678715
89	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.62520255
90	Insulin secretion_Homo sapiens_hsa04911	0.61919221
91	Glioma_Homo sapiens_hsa05214	0.61034904
92	Estrogen signaling pathway_Homo sapiens_hsa04915	0.60425988
93	Leishmaniasis_Homo sapiens_hsa05140	0.60072156
94	Herpes simplex infection_Homo sapiens_hsa05168	0.59975803
95	Allograft rejection_Homo sapiens_hsa05330	0.59721710
96	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.57609430
97	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.55720009
98	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.55470151
99	Regulation of autophagy_Homo sapiens_hsa04140	0.55108385
100	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.55076003

SMG1P7

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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