SMG5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: SMG5 is involved in nonsense-mediated mRNA decay (Ohnishi et al., 2003 [PubMed 14636577]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1polyketide metabolic process (GO:0030638)8.05804721
2doxorubicin metabolic process (GO:0044598)8.05804721
3daunorubicin metabolic process (GO:0044597)8.05804721
4protein localization to kinetochore (GO:0034501)6.26444437
5maintenance of protein location in nucleus (GO:0051457)5.87349082
6negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)5.63185516
7regulation of mammary gland epithelial cell proliferation (GO:0033599)5.55329101
8heterochromatin organization (GO:0070828)5.55133048
9histone H4-K8 acetylation (GO:0043982)5.54204204
10histone H4-K5 acetylation (GO:0043981)5.54204204
11regulation of response to osmotic stress (GO:0047484)5.50701773
12histone H4-K12 acetylation (GO:0043983)5.44826926
13nuclear pore complex assembly (GO:0051292)5.44722569
14regulation of telomere maintenance via telomerase (GO:0032210)5.40813206
15mitotic sister chromatid segregation (GO:0000070)5.29205297
16negative regulation of epidermis development (GO:0045683)5.22541179
17regulation of nuclear cell cycle DNA replication (GO:0033262)5.19196080
18aminoglycoside antibiotic metabolic process (GO:0030647)5.18313395
19somite rostral/caudal axis specification (GO:0032525)5.17245979
20negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)5.06344611
21negative regulation of cell cycle G2/M phase transition (GO:1902750)5.04119019
22Golgi transport vesicle coating (GO:0048200)4.98849357
23COPI coating of Golgi vesicle (GO:0048205)4.98849357
24negative regulation of telomerase activity (GO:0051974)4.98048518
25protein localization to chromosome, centromeric region (GO:0071459)4.90848069
26nuclear pore organization (GO:0006999)4.88568472
27pre-miRNA processing (GO:0031054)4.79478213
28DNA replication-dependent nucleosome organization (GO:0034723)4.77566427
29DNA replication-dependent nucleosome assembly (GO:0006335)4.77566427
30muscle organ morphogenesis (GO:0048644)4.73457725
31chromatin assembly (GO:0031497)4.72200649
32sister chromatid segregation (GO:0000819)4.65576262
33rRNA transcription (GO:0009303)4.62609865
34histone H4-K16 acetylation (GO:0043984)4.35070446
35regulation of MHC class I biosynthetic process (GO:0045343)4.30792697
36notochord development (GO:0030903)4.28001220
37regulation of cilium movement (GO:0003352)4.25459778
38protein localization to endosome (GO:0036010)4.08742012
39pore complex assembly (GO:0046931)4.05741312
40mRNA stabilization (GO:0048255)3.99342316
41RNA stabilization (GO:0043489)3.99342316
42positive regulation of DNA-dependent DNA replication (GO:2000105)3.98434126
43negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.95688813
44adherens junction assembly (GO:0034333)3.94816881
45focal adhesion assembly (GO:0048041)3.89833043
46cell-substrate adherens junction assembly (GO:0007045)3.89833043
47regulation of gene silencing by RNA (GO:0060966)3.86720051
48regulation of posttranscriptional gene silencing (GO:0060147)3.86720051
49regulation of gene silencing by miRNA (GO:0060964)3.86720051
50negative regulation of epidermal cell differentiation (GO:0045605)3.85684195
51hormone catabolic process (GO:0042447)3.84002702
52retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.81433595
53branching involved in mammary gland duct morphogenesis (GO:0060444)3.75304598
54regulation of translation in response to stress (GO:0043555)3.73432544
55activation of Rac GTPase activity (GO:0032863)3.72202441
56positive regulation of histone deacetylation (GO:0031065)3.70992733
57proline biosynthetic process (GO:0006561)3.70719755
58regulation of hippo signaling (GO:0035330)3.69933172
59cytidine metabolic process (GO:0046087)3.69062838
60cytidine catabolic process (GO:0006216)3.69062838
61cytidine deamination (GO:0009972)3.69062838
62apoptotic process involved in morphogenesis (GO:0060561)3.67242763
63DNA duplex unwinding (GO:0032508)3.65894768
64trophectodermal cell differentiation (GO:0001829)3.64495493
65DNA replication checkpoint (GO:0000076)3.64125690
66positive regulation of protein deacetylation (GO:0090312)3.61226440
67DNA geometric change (GO:0032392)3.61045709
68regulation of intracellular estrogen receptor signaling pathway (GO:0033146)3.57966180
69mitotic chromosome condensation (GO:0007076)3.57617016
70negative regulation of erythrocyte differentiation (GO:0045647)3.53631765
71rRNA methylation (GO:0031167)3.53334247
72NLS-bearing protein import into nucleus (GO:0006607)3.50281370
73primitive streak formation (GO:0090009)3.49265816
74cell fate commitment involved in formation of primary germ layer (GO:0060795)3.48039255
75spliceosomal tri-snRNP complex assembly (GO:0000244)3.47854906
76cytoskeletal anchoring at plasma membrane (GO:0007016)3.47786683
77maternal placenta development (GO:0001893)3.47508594
78interferon-gamma production (GO:0032609)3.46113478
79negative regulation of telomere maintenance (GO:0032205)3.45174889
80intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)3.44184084
81protein retention in ER lumen (GO:0006621)3.43626096
82intracellular estrogen receptor signaling pathway (GO:0030520)3.36681155
83maintenance of protein localization in organelle (GO:0072595)3.35817785
84regulation of glucose import in response to insulin stimulus (GO:2001273)3.35762650
85intestinal epithelial cell development (GO:0060576)3.34134175
86maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.33741667
87cell-substrate junction assembly (GO:0007044)3.32875089
88nucleoside transmembrane transport (GO:1901642)3.30791158
89regulation of apoptotic process involved in morphogenesis (GO:1902337)3.30485128
90mannose metabolic process (GO:0006013)3.29574844
91intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)3.29279485
92regulation of NFAT protein import into nucleus (GO:0051532)3.27577168
93retinoic acid receptor signaling pathway (GO:0048384)3.27130146
94microtubule severing (GO:0051013)3.24696203
95DNA unwinding involved in DNA replication (GO:0006268)3.24011101
96regulation of translational fidelity (GO:0006450)3.23845784
97embryonic process involved in female pregnancy (GO:0060136)3.23203209
98response to dietary excess (GO:0002021)3.18036018
99regulation of telomere maintenance (GO:0032204)3.16521368
100rRNA modification (GO:0000154)3.15971275
101negative regulation of potassium ion transmembrane transport (GO:1901380)3.15596733
102regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.15564808
103epithelial cell differentiation involved in prostate gland development (GO:0060742)3.14338897
104regulation of early endosome to late endosome transport (GO:2000641)3.11491029
105pentose-phosphate shunt (GO:0006098)3.11217682
106planar cell polarity pathway involved in neural tube closure (GO:0090179)3.10416089
107spindle assembly (GO:0051225)3.09754537
108epithelial cell-cell adhesion (GO:0090136)3.08942754
109regulation of nucleobase-containing compound transport (GO:0032239)3.06650920
110chromosome condensation (GO:0030261)3.05685582
1113-UTR-mediated mRNA stabilization (GO:0070935)3.02290376
112semaphorin-plexin signaling pathway (GO:0071526)2.99146583
113phenol-containing compound catabolic process (GO:0019336)2.98009809
114cellular protein complex localization (GO:0034629)2.97649545
115protein polyglutamylation (GO:0018095)2.95110930
116activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.94228047
117ribosome biogenesis (GO:0042254)2.93477654
118regulation of RNA export from nucleus (GO:0046831)2.93199607
119transcription from mitochondrial promoter (GO:0006390)2.92805536
120mitochondrion distribution (GO:0048311)2.92161616
121DNA conformation change (GO:0071103)2.90638753
122pinocytosis (GO:0006907)2.89554485
123cellular modified amino acid catabolic process (GO:0042219)2.89519152
124negative regulation of peptidyl-serine phosphorylation (GO:0033137)2.89459204
125negative regulation of cell size (GO:0045792)2.87420852
126cardiovascular system development (GO:0072358)2.87297343
127protein complex localization (GO:0031503)2.86757368
128pyrimidine ribonucleoside catabolic process (GO:0046133)2.86067491
129regulation of histone H3-K27 methylation (GO:0061085)2.85753159
130apoptotic DNA fragmentation (GO:0006309)2.85347254
131positive regulation of nuclease activity (GO:0032075)2.84755240
132regulation of telomerase activity (GO:0051972)2.83725635
133regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.83319382
134hypotonic response (GO:0006971)2.82776755
135bone trabecula formation (GO:0060346)2.82421952
136basement membrane organization (GO:0071711)2.81564574
137cell migration involved in gastrulation (GO:0042074)2.81507597
138positive regulation of Cdc42 GTPase activity (GO:0043089)2.81477737
139regulation of chromatin binding (GO:0035561)2.80693289
140regulation of double-strand break repair (GO:2000779)2.80597043
141stress fiber assembly (GO:0043149)2.80469784
142barbed-end actin filament capping (GO:0051016)2.77929515
143glucose 6-phosphate metabolic process (GO:0051156)2.76431948
144regulation of cholesterol homeostasis (GO:2000188)2.74960681
145cellular response to epidermal growth factor stimulus (GO:0071364)2.73012082
146negative regulation of fatty acid transport (GO:2000192)2.71873689
147glucose catabolic process (GO:0006007)2.70922000
148NADPH regeneration (GO:0006740)2.68157890
149protein export from nucleus (GO:0006611)2.67503423
150negative regulation of viral release from host cell (GO:1902187)2.65194433
151proline metabolic process (GO:0006560)2.60757658
152peptidyl-arginine omega-N-methylation (GO:0035247)2.59627938
153response to laminar fluid shear stress (GO:0034616)2.58509706
154endoplasmic reticulum unfolded protein response (GO:0030968)2.56731229
155regulation of nuclease activity (GO:0032069)2.56531884
156negative regulation of myotube differentiation (GO:0010832)2.54987994
157urea cycle (GO:0000050)2.54657784
158desmosome organization (GO:0002934)2.54066319
159ER-nucleus signaling pathway (GO:0006984)2.52033920
160histone H3-K36 demethylation (GO:0070544)2.51236196
161cellular hyperosmotic response (GO:0071474)2.49670600
162peptidyl-lysine dimethylation (GO:0018027)2.49581380
163positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.46491487
164positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.45960037
165hemidesmosome assembly (GO:0031581)2.44952547
166positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.43679033
167modulation by symbiont of host cellular process (GO:0044068)2.43096702
168protein-DNA complex disassembly (GO:0032986)2.42753270
169nucleosome disassembly (GO:0006337)2.42753270
170positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.42504456
171vesicle coating (GO:0006901)2.42159652
172negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.41815373
173amyloid precursor protein catabolic process (GO:0042987)2.38339345
174regulation of cholesterol biosynthetic process (GO:0045540)2.36300028
175glucocorticoid receptor signaling pathway (GO:0042921)2.35742789
176response to epidermal growth factor (GO:0070849)2.35263939
177negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.33619298
178urea metabolic process (GO:0019627)2.33201990
179cellular response to unfolded protein (GO:0034620)2.33023076
180skin morphogenesis (GO:0043589)2.28967986
181positive regulation of blood vessel endothelial cell migration (GO:0043536)2.27949340
182negative regulation of necroptotic process (GO:0060546)2.27428590
183activation of MAPKKK activity (GO:0000185)2.26005057
184insulin-like growth factor receptor signaling pathway (GO:0048009)2.25730606
185NADH metabolic process (GO:0006734)2.23670991
186positive regulation of receptor recycling (GO:0001921)2.23645067

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.60737254
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse5.42183503
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse5.42183503
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse5.42183503
5BP1_19119308_ChIP-ChIP_Hs578T_Human4.19642824
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.20377188
7SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.04712059
8TP63_17297297_ChIP-ChIP_HaCaT_Human3.00084045
9NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.96106706
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.84821534
11TP63_19390658_ChIP-ChIP_HaCaT_Human2.74765227
12SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.67371654
13POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.66284978
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.54643930
15SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.52969358
16TCF3_18692474_ChIP-Seq_MESCs_Mouse2.29258378
17ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.20907510
18MYC_22102868_ChIP-Seq_BL_Human2.20473645
19ZNF263_19887448_ChIP-Seq_K562_Human2.16795281
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.16517230
21TCF3_18692474_ChIP-Seq_MEFs_Mouse2.11353946
22RARG_19884340_ChIP-ChIP_MEFs_Mouse2.11197508
23NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.09216437
24* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.07681248
25MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.05760739
26FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.91088950
27* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.88377270
28KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.84996528
29PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.82180164
30CLOCK_20551151_ChIP-Seq_293T_Human1.79457335
31NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.78699180
32ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.77326173
33TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.76433141
34* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.73933955
35KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.71675163
36MYC_19079543_ChIP-ChIP_MESCs_Mouse1.70677763
37NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.69274362
38POU5F1_16518401_ChIP-PET_MESCs_Mouse1.69127390
39HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.67690824
40RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.66750639
41ZFP281_18757296_ChIP-ChIP_E14_Mouse1.66509950
42ZFP281_27345836_Chip-Seq_ESCs_Mouse1.64053669
43SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.63842269
44HIF1A_21447827_ChIP-Seq_MCF-7_Human1.63566141
45KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.60269914
46MYC_18555785_ChIP-Seq_MESCs_Mouse1.59839010
47ESR2_21235772_ChIP-Seq_MCF-7_Human1.58926728
48P300_27058665_Chip-Seq_ZR-75-30cells_Human1.58924355
49NANOG_18555785_ChIP-Seq_MESCs_Mouse1.57877151
50TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.50407469
51TCF7_22412390_ChIP-Seq_EML_Mouse1.48890827
52CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.45271166
53* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.44815313
54POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.44814148
55EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43038289
56CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.42909939
57UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.41396314
58SOX2_18555785_ChIP-Seq_MESCs_Mouse1.41229258
59EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.39752971
60TET1_21451524_ChIP-Seq_MESCs_Mouse1.37372975
61EGR1_19374776_ChIP-ChIP_THP-1_Human1.37307184
62NANOG_18692474_ChIP-Seq_MESCs_Mouse1.36737857
63TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.36373966
64KDM2B_26808549_Chip-Seq_SUP-B15_Human1.35161004
65* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.34938717
66EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.34566404
67ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.34530281
68* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.34493918
69* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.34158952
70POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.32977839
71KDM2B_26808549_Chip-Seq_JURKAT_Human1.32732142
72PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.32358800
73* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.31530678
74MAF_26560356_Chip-Seq_TH1_Human1.31029193
75SOX2_18692474_ChIP-Seq_MESCs_Mouse1.29935899
76* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.29630988
77STAT6_21828071_ChIP-Seq_BEAS2B_Human1.29590016
78ATF3_27146783_Chip-Seq_COLON_Human1.29336062
79* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.28159205
80CREB1_26743006_Chip-Seq_LNCaP_Human1.28119380
81NCOR1_26117541_ChIP-Seq_K562_Human1.26682921
82VDR_24763502_ChIP-Seq_THP-1_Human1.26355165
83KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.25788272
84TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25098421
85SA1_27219007_Chip-Seq_ERYTHROID_Human1.24522694
86ERG_21242973_ChIP-ChIP_JURKAT_Human1.23584694
87NANOG_21062744_ChIP-ChIP_HESCs_Human1.22690121
88NANOG_18692474_ChIP-Seq_MEFs_Mouse1.21958123
89TP53_22127205_ChIP-Seq_IMR90_Human1.20998726
90SRY_22984422_ChIP-ChIP_TESTIS_Rat1.20859729
91BRD4_27068464_Chip-Seq_AML-cells_Mouse1.20672757
92* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.19490371
93OCT4_18692474_ChIP-Seq_MEFs_Mouse1.14980595
94TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.14554314
95SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.14509354
96* MAF_26560356_Chip-Seq_TH2_Human1.12958911
97ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.12516824
98E2F1_17053090_ChIP-ChIP_MCF-7_Human1.12401227
99SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.12287947
100RUNX1_27514584_Chip-Seq_MCF-7_Human1.10348538
101HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.09706023
102UTX_26944678_Chip-Seq_JUKART_Human1.09170638
103KLF4_18555785_ChIP-Seq_MESCs_Mouse1.08725156
104RUNX1_22412390_ChIP-Seq_EML_Mouse1.08440519
105GATA1_22383799_ChIP-Seq_G1ME_Mouse1.08129252
106YY1_21170310_ChIP-Seq_MESCs_Mouse1.07995091
107* ELK3_25401928_ChIP-Seq_HUVEC_Human1.06849918
108NANOG_16518401_ChIP-PET_MESCs_Mouse1.06625408
109* XRN2_22483619_ChIP-Seq_HELA_Human1.05809232
110SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05060136
111KDM2B_26808549_Chip-Seq_DND41_Human1.05026861
112KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.04433557
113DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.04229772
114UBF1/2_26484160_Chip-Seq_HMECs_Human1.04021865
115NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.03610494
116TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.03128946
117* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.02006312
118TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01651212
119KDM2B_26808549_Chip-Seq_K562_Human1.01251256
120RACK7_27058665_Chip-Seq_MCF-7_Human1.00770617
121SOX2_18692474_ChIP-Seq_MEFs_Mouse1.00306816
122LXR_22292898_ChIP-Seq_THP-1_Human0.99964165
123PPARA_22158963_ChIP-Seq_LIVER_Mouse0.99624237
124CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.98916986
125TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98225659
126IRF1_19129219_ChIP-ChIP_H3396_Human0.97682333
127SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.95905222
128PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95866114
129P68_20966046_ChIP-Seq_HELA_Human0.95821283
130POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.95542531
131TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.95356194
132SMC4_20622854_ChIP-Seq_HELA_Human0.95276443
133CHD1_26751641_Chip-Seq_LNCaP_Human0.95123700
134E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.95014010
135NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.94393815
136ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.93982882
137NANOG_16153702_ChIP-ChIP_HESCs_Human0.90820556
138ELF1_20517297_ChIP-Seq_JURKAT_Human0.90512826
139VDR_21846776_ChIP-Seq_THP-1_Human0.86441345
140KAP1_27257070_Chip-Seq_ESCs_Mouse0.85495177
141CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.84812304
142DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.83854894
143RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.83488103
144AR_21909140_ChIP-Seq_LNCAP_Human0.83316005
145ESR1_15608294_ChIP-ChIP_MCF-7_Human0.82907706
146PHF8_20622854_ChIP-Seq_HELA_Human0.82747878
147CIITA_25753668_ChIP-Seq_RAJI_Human0.82261847
148YY1_22570637_ChIP-Seq_MALME-3M_Human0.81826316
149* KDM5A_27292631_Chip-Seq_BREAST_Human0.81067494
150WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.81062407
151TBX3_20139965_ChIP-Seq_ESCs_Mouse0.80648910
152CDX2_20551321_ChIP-Seq_CACO-2_Human0.80534553
153BCOR_27268052_Chip-Seq_Bcells_Human0.79246335
154TBX3_20139965_ChIP-Seq_MESCs_Mouse0.78999000
155NOTCH1_21737748_ChIP-Seq_TLL_Human0.78570874
156CTCF_21964334_Chip-Seq_Bcells_Human0.78462495

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004264_abnormal_extraembryonic_tissu3.92826480
2MP0005451_abnormal_body_composition3.73540246
3MP0002254_reproductive_system_inflammat3.39932601
4MP0003705_abnormal_hypodermis_morpholog3.39269082
5MP0003890_abnormal_embryonic-extraembry3.38055346
6MP0003011_delayed_dark_adaptation3.30633715
7MP0008057_abnormal_DNA_replication3.16617730
8MP0006292_abnormal_olfactory_placode2.96480145
9MP0004858_abnormal_nervous_system2.89992852
10MP0005499_abnormal_olfactory_system2.88190698
11MP0005394_taste/olfaction_phenotype2.88190698
12MP0004957_abnormal_blastocyst_morpholog2.87822016
13MP0010352_gastrointestinal_tract_polyps2.85600377
14MP0010234_abnormal_vibrissa_follicle2.73919173
15MP0004185_abnormal_adipocyte_glucose2.58624321
16MP0002653_abnormal_ependyma_morphology2.54461045
17MP0005058_abnormal_lysosome_morphology2.49760845
18MP0008260_abnormal_autophagy2.44285008
19MP0003122_maternal_imprinting2.29477432
20MP0004233_abnormal_muscle_weight2.26936009
21MP0005075_abnormal_melanosome_morpholog2.22893411
22MP0002332_abnormal_exercise_endurance2.21941608
23MP0009840_abnormal_foam_cell2.21276662
24MP0001672_abnormal_embryogenesis/_devel2.20631819
25MP0005380_embryogenesis_phenotype2.20631819
26MP0003121_genomic_imprinting2.20221670
27MP0005257_abnormal_intraocular_pressure2.13192928
28MP0002088_abnormal_embryonic_growth/wei2.04166532
29MP0003984_embryonic_growth_retardation2.03788977
30MP0008961_abnormal_basal_metabolism2.02938923
31MP0003111_abnormal_nucleus_morphology2.00652471
32MP0003453_abnormal_keratinocyte_physiol1.96154845
33MP0003077_abnormal_cell_cycle1.87097442
34MP0001849_ear_inflammation1.81739252
35MP0000350_abnormal_cell_proliferation1.80958218
36MP0010030_abnormal_orbit_morphology1.80633452
37MP0005409_darkened_coat_color1.79748346
38MP0003191_abnormal_cellular_cholesterol1.79661875
39MP0003091_abnormal_cell_migration1.77570892
40MP0006035_abnormal_mitochondrial_morpho1.75608410
41MP0002796_impaired_skin_barrier1.74713231
42MP0000537_abnormal_urethra_morphology1.71756997
43MP0002086_abnormal_extraembryonic_tissu1.68046863
44MP0003123_paternal_imprinting1.66285773
45MP0000678_abnormal_parathyroid_gland1.63438938
46MP0002085_abnormal_embryonic_tissue1.62420532
47MP0001293_anophthalmia1.62218294
48MP0010094_abnormal_chromosome_stability1.60700487
49MP0002084_abnormal_developmental_patter1.58385908
50MP0003300_gastrointestinal_ulcer1.56978174
51MP0000751_myopathy1.55273936
52MP0008438_abnormal_cutaneous_collagen1.54239119
53MP0005666_abnormal_adipose_tissue1.54182100
54MP0009672_abnormal_birth_weight1.52185283
55MP0004197_abnormal_fetal_growth/weight/1.51683081
56MP0001730_embryonic_growth_arrest1.51133742
57MP0002127_abnormal_cardiovascular_syste1.47026276
58MP0002092_abnormal_eye_morphology1.45915484
59MP0000858_altered_metastatic_potential1.45109933
60MP0009278_abnormal_bone_marrow1.44603226
61MP0000003_abnormal_adipose_tissue1.41587984
62MP0003172_abnormal_lysosome_physiology1.40165965
63MP0002089_abnormal_postnatal_growth/wei1.37923493
64MP0003938_abnormal_ear_development1.37388065
65MP0005501_abnormal_skin_physiology1.35485730
66MP0003283_abnormal_digestive_organ1.34950590
67MP0002932_abnormal_joint_morphology1.33918458
68MP0005375_adipose_tissue_phenotype1.32165889
69MP0004272_abnormal_basement_membrane1.30554579
70MP0003119_abnormal_digestive_system1.28903761
71MP0000747_muscle_weakness1.26864856
72MP0001697_abnormal_embryo_size1.26562273
73MP0000428_abnormal_craniofacial_morphol1.26082127
74MP0004947_skin_inflammation1.24390816
75MP0002396_abnormal_hematopoietic_system1.23494336
76MP0003329_amyloid_beta_deposits1.21540369
77MP0005621_abnormal_cell_physiology1.20797355
78MP0002080_prenatal_lethality1.18845761
79MP0002249_abnormal_larynx_morphology1.18592128
80MP0001348_abnormal_lacrimal_gland1.18360122
81MP0008770_decreased_survivor_rate1.17657925
82MP0003303_peritoneal_inflammation1.17280840
83MP0002060_abnormal_skin_morphology1.15116275
84MP0001915_intracranial_hemorrhage1.14944632
85MP0002269_muscular_atrophy1.14902636
86MP0003935_abnormal_craniofacial_develop1.13380555
87MP0004087_abnormal_muscle_fiber1.12993978
88MP0004808_abnormal_hematopoietic_stem1.12851973
89MP0003436_decreased_susceptibility_to1.11176354
90MP0005623_abnormal_meninges_morphology1.11035079
91MP0005410_abnormal_fertilization1.09616797
92MP0000432_abnormal_head_morphology1.07746390
93MP0004133_heterotaxia1.07528975
94MP0002114_abnormal_axial_skeleton1.07180905
95MP0000762_abnormal_tongue_morphology1.06853487
96MP0000313_abnormal_cell_death1.05846639
97MP0003693_abnormal_embryo_hatching1.05480495
98MP0002925_abnormal_cardiovascular_devel1.04064574
99MP0000750_abnormal_muscle_regeneration1.03591013
100MP0002970_abnormal_white_adipose1.02690378
101MP0005266_abnormal_metabolism1.02175946
102MP0003787_abnormal_imprinting1.02169222
103MP0003183_abnormal_peptide_metabolism1.02003939
104MP0001661_extended_life_span1.01730463
105MP0008789_abnormal_olfactory_epithelium1.00853952
106MP0004510_myositis0.99991397
107MP0002233_abnormal_nose_morphology0.99721173
108MP0009703_decreased_birth_body0.98560226
109MP0005076_abnormal_cell_differentiation0.95651063
110MP0000049_abnormal_middle_ear0.94758054
111MP0000490_abnormal_crypts_of0.94726599
112MP0002877_abnormal_melanocyte_morpholog0.94603922
113MP0003137_abnormal_impulse_conducting0.94275464
114MP0008007_abnormal_cellular_replicative0.93956106
115MP0002009_preneoplasia0.93632994
116MP0008932_abnormal_embryonic_tissue0.93232203
117MP0002277_abnormal_respiratory_mucosa0.92270758
118MP0005023_abnormal_wound_healing0.92024116
119MP0001216_abnormal_epidermal_layer0.90800297
120MP0003755_abnormal_palate_morphology0.90558942
121MP0003115_abnormal_respiratory_system0.90003314
122MP0009333_abnormal_splenocyte_physiolog0.87523246
123MP0000467_abnormal_esophagus_morphology0.85147444
124MP0003221_abnormal_cardiomyocyte_apopto0.83822732
125MP0005248_abnormal_Harderian_gland0.82888598
126MP0002098_abnormal_vibrissa_morphology0.82742451
127MP0003566_abnormal_cell_adhesion0.81695865
128MP0009931_abnormal_skin_appearance0.81379824
129MP0001346_abnormal_lacrimal_gland0.81379434
130MP0006082_CNS_inflammation0.81124261
131MP0005330_cardiomyopathy0.79546357
132MP0005391_vision/eye_phenotype0.78720540
133MP0006138_congestive_heart_failure0.78173349
134MP0000749_muscle_degeneration0.76509922
135MP0009053_abnormal_anal_canal0.76146894
136MP0000358_abnormal_cell_content/0.75355503
137MP0003861_abnormal_nervous_system0.74718025
138MP0000579_abnormal_nail_morphology0.74298941
139MP0002896_abnormal_bone_mineralization0.74131366
140MP0002998_abnormal_bone_remodeling0.73876536
141MP0003634_abnormal_glial_cell0.73429665
142MP0002116_abnormal_craniofacial_bone0.73187668
143MP0010630_abnormal_cardiac_muscle0.72840392
144MP0010307_abnormal_tumor_latency0.71293056
145MP0000377_abnormal_hair_follicle0.71107474
146MP0001873_stomach_inflammation0.71077565
147MP0000477_abnormal_intestine_morphology0.70813131
148MP0005384_cellular_phenotype0.69963322
149MP0003763_abnormal_thymus_physiology0.69263543
150MP0002111_abnormal_tail_morphology0.67886800
151MP0002697_abnormal_eye_size0.67415825
152MP0000266_abnormal_heart_morphology0.66715793
153MP0002081_perinatal_lethality0.66595838
154MP0000759_abnormal_skeletal_muscle0.65566337
155MP0000733_abnormal_muscle_development0.65212217
156MP0005508_abnormal_skeleton_morphology0.64305900
157MP0004043_abnormal_pH_regulation0.64160632
158MP0002019_abnormal_tumor_incidence0.63748708
159MP0003937_abnormal_limbs/digits/tail_de0.63648835

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)6.33799032
2Hypochromic microcytic anemia (HP:0004840)5.46039650
3Abnormality of the lower motor neuron (HP:0002366)5.37486821
4Ependymoma (HP:0002888)4.88493556
5Hepatoblastoma (HP:0002884)4.60832925
6Multiple enchondromatosis (HP:0005701)4.60324944
7Rib fusion (HP:0000902)4.48529764
8Neoplasm of striated muscle (HP:0009728)3.83526225
9Abnormality of the astrocytes (HP:0100707)3.74566439
10Astrocytoma (HP:0009592)3.74566439
11Hyperacusis (HP:0010780)3.73390275
12Chromosomal breakage induced by crosslinking agents (HP:0003221)3.50913974
13Rhabdomyosarcoma (HP:0002859)3.49750555
14Distal lower limb amyotrophy (HP:0008944)3.28734949
15Nephroblastoma (Wilms tumor) (HP:0002667)3.11958502
16Amyotrophic lateral sclerosis (HP:0007354)3.07565611
17Testicular atrophy (HP:0000029)3.04900370
18Short humerus (HP:0005792)2.99396949
19Chromsome breakage (HP:0040012)2.97952246
20Aplasia/hypoplasia of the humerus (HP:0006507)2.91295821
21Flat acetabular roof (HP:0003180)2.88970369
22Embryonal renal neoplasm (HP:0011794)2.86903052
23Rectal fistula (HP:0100590)2.86158191
24Rectovaginal fistula (HP:0000143)2.86158191
25Abnormality of the salivary glands (HP:0010286)2.85776923
26Broad face (HP:0000283)2.83869745
27Fused cervical vertebrae (HP:0002949)2.81962957
28Intestinal fistula (HP:0100819)2.81258574
29Centrally nucleated skeletal muscle fibers (HP:0003687)2.80536922
30Difficulty running (HP:0009046)2.77244765
31Glioma (HP:0009733)2.74253731
32Increased connective tissue (HP:0009025)2.74127080
33Renal duplication (HP:0000075)2.71086413
34Hand muscle atrophy (HP:0009130)2.69509608
35Distal lower limb muscle weakness (HP:0009053)2.62947275
36Cerebral aneurysm (HP:0004944)2.62038299
37Preauricular skin tag (HP:0000384)2.61621070
38Vertebral compression fractures (HP:0002953)2.61569058
39Neoplasm of the heart (HP:0100544)2.56099696
40Protrusio acetabuli (HP:0003179)2.54943415
41Hypopigmentation of the fundus (HP:0007894)2.54572910
42Hyperinsulinemic hypoglycemia (HP:0000825)2.53370236
43Premature rupture of membranes (HP:0001788)2.52844656
44Impulsivity (HP:0100710)2.51639426
45Pseudobulbar signs (HP:0002200)2.51485008
46Trismus (HP:0000211)2.50688134
47Skin tags (HP:0010609)2.49789627
48Lower limb amyotrophy (HP:0007210)2.47409611
49Bifid tongue (HP:0010297)2.46516598
50Aplasia/Hypoplasia of the fovea (HP:0008060)2.45486277
51Hypoplasia of the fovea (HP:0007750)2.45486277
52Ragged-red muscle fibers (HP:0003200)2.45229465
53Resting tremor (HP:0002322)2.44879062
54Vaginal fistula (HP:0004320)2.43337920
55Distal upper limb amyotrophy (HP:0007149)2.42990703
56Upper limb amyotrophy (HP:0009129)2.42990703
57Large earlobe (HP:0009748)2.42710394
58Partial duplication of thumb phalanx (HP:0009944)2.40552565
59Abnormality of chromosome segregation (HP:0002916)2.36524433
60Hypochromic anemia (HP:0001931)2.35898507
61Horizontal nystagmus (HP:0000666)2.35391671
62Asymmetry of the thorax (HP:0001555)2.34487721
63Aplasia/Hypoplasia of the uvula (HP:0010293)2.33111979
64Abnormal lung lobation (HP:0002101)2.32382068
65Meckel diverticulum (HP:0002245)2.31977570
66Dysmetric saccades (HP:0000641)2.31198823
67Generalized hypotonia (HP:0001290)2.31121690
68Abnormal cartilage morphology (HP:0002763)2.30863929
69Deep venous thrombosis (HP:0002625)2.29717345
70Shawl scrotum (HP:0000049)2.28245677
71Insomnia (HP:0100785)2.25027750
72Abnormality of the musculature of the hand (HP:0001421)2.23678427
73Disproportionate tall stature (HP:0001519)2.20889408
74Long palpebral fissure (HP:0000637)2.19843147
75Short 5th finger (HP:0009237)2.19619941
76Abnormality of the ileum (HP:0001549)2.18434785
77Preauricular pit (HP:0004467)2.18373216
78Periauricular skin pits (HP:0100277)2.18373216
79Thin bony cortex (HP:0002753)2.17847689
80Upper motor neuron abnormality (HP:0002127)2.16412680
81Progressive muscle weakness (HP:0003323)2.16200651
82Achilles tendon contracture (HP:0001771)2.16122983
83Abnormality of the distal phalanx of the thumb (HP:0009617)2.14442519
84Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.12491522
85Medulloblastoma (HP:0002885)2.12179431
86Partial duplication of the phalanx of hand (HP:0009999)2.10913552
87Ankyloglossia (HP:0010296)2.10055488
88Abnormality of the pubic bones (HP:0003172)2.09976070
89Missing ribs (HP:0000921)2.09431711
90Obstructive sleep apnea (HP:0002870)2.09182552
91Nasal polyposis (HP:0100582)2.07795070
92Malignant neoplasm of the central nervous system (HP:0100836)2.06866395
93Difficulty climbing stairs (HP:0003551)2.06364192
94EMG: neuropathic changes (HP:0003445)2.06125589
95Vertebral fusion (HP:0002948)2.02192462
96Tetraplegia (HP:0002445)2.01839179
97Anomalous pulmonary venous return (HP:0010772)2.01816072
98Adenoma sebaceum (HP:0009720)2.01279394
99Angiofibromas (HP:0010615)2.01279394
100Aplasia/Hypoplasia of the sternum (HP:0006714)2.00797992
101Hemorrhage of the eye (HP:0011885)1.99328579
102Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.99013615
103Advanced eruption of teeth (HP:0006288)1.97706270
104Short nail (HP:0001799)1.97556371
105Cervical subluxation (HP:0003308)1.93605676
106Cerebral inclusion bodies (HP:0100314)1.93119355
107Abnormality of the fingertips (HP:0001211)1.93056947
108Shallow orbits (HP:0000586)1.92658783
109Abnormality of the distal phalanges of the toes (HP:0010182)1.92205956
110Increased variability in muscle fiber diameter (HP:0003557)1.91858615
111Myopathic facies (HP:0002058)1.91478750
112Atrophy/Degeneration involving motor neurons (HP:0007373)1.91015143
113Abnormality of the Achilles tendon (HP:0005109)1.91006509
114Abnormality of oral frenula (HP:0000190)1.90441083
115Ulnar bowing (HP:0003031)1.89474689
116Spinal muscular atrophy (HP:0007269)1.89404162
117Back pain (HP:0003418)1.89027644
118Mildly elevated creatine phosphokinase (HP:0008180)1.88992992
119Neoplasm of the oral cavity (HP:0100649)1.88109027
120Supernumerary ribs (HP:0005815)1.87905432
121Selective tooth agenesis (HP:0001592)1.87826673
122Aplasia/Hypoplasia of the macula (HP:0008059)1.87489616
123Skin pits (HP:0100276)1.87103939
124Abnormality of skeletal muscle fiber size (HP:0012084)1.86171713
125Prominent occiput (HP:0000269)1.86102513
126Small intestinal stenosis (HP:0012848)1.85999783
127Duodenal stenosis (HP:0100867)1.85999783
128Supernumerary spleens (HP:0009799)1.84674002
129Metaphyseal cupping (HP:0003021)1.84528935
130Abnormality of the thoracic spine (HP:0100711)1.83319574
131Upper limb muscle weakness (HP:0003484)1.82961585
132Abnormality of the phalanges of the hallux (HP:0010057)1.82236963
133Stridor (HP:0010307)1.80583784
134Increased nuchal translucency (HP:0010880)1.80220188
135Cholecystitis (HP:0001082)1.79467057
136Abnormal gallbladder physiology (HP:0012438)1.79467057
137Progressive external ophthalmoplegia (HP:0000590)1.78581537
138Tongue fasciculations (HP:0001308)1.78460720
139Aneurysm (HP:0002617)1.77169652
140Fragile skin (HP:0001030)1.76381959
141Muscle fibrillation (HP:0010546)1.76180567
142Heterotopia (HP:0002282)1.75968127
143Syringomyelia (HP:0003396)1.75605197
144Spinal cord lesions (HP:0100561)1.75605197
145Abnormality of the calcaneus (HP:0008364)1.74719105
146Mitral regurgitation (HP:0001653)1.74675367
147Pointed chin (HP:0000307)1.73898872
148Biconcave vertebral bodies (HP:0004586)1.73716062
149Sparse lateral eyebrow (HP:0005338)1.72864484
150Patellar dislocation (HP:0002999)1.72753292
151Spinal rigidity (HP:0003306)1.72634697
152Osteolytic defects of the hand bones (HP:0009699)1.70873785
153Osteolytic defects of the phalanges of the hand (HP:0009771)1.70873785
154Termporal pattern (HP:0011008)1.70416221
155Insidious onset (HP:0003587)1.70416221
156Reticulocytosis (HP:0001923)1.69146931
157Exercise-induced myalgia (HP:0003738)1.69063817
158Abnormal ossification of hand bones (HP:0005921)1.68709935
159Natal tooth (HP:0000695)1.67366147
160Segmental peripheral demyelination/remyelination (HP:0003481)1.64788833
161Abnormality of carpal bone ossification (HP:0006257)1.63973303
162Cellulitis (HP:0100658)1.63348446
163Blue sclerae (HP:0000592)1.62520197
164Colitis (HP:0002583)1.61800727
165Turricephaly (HP:0000262)1.61300217
166Broad distal phalanx of finger (HP:0009836)1.60962248
167Interstitial pulmonary disease (HP:0006530)1.60008460
168Arnold-Chiari malformation (HP:0002308)1.57979665
169Distal sensory impairment (HP:0002936)1.57922312
170Deviation of the thumb (HP:0009603)1.57578408
171Bowel incontinence (HP:0002607)1.57030240
172Hammertoe (HP:0001765)1.56890807
173Dislocated radial head (HP:0003083)1.56752013
174Bone pain (HP:0002653)1.55544653
175Hyperparathyroidism (HP:0000843)1.54961988
176Myocardial infarction (HP:0001658)1.53137975
177Subacute progressive viral hepatitis (HP:0006572)1.53084276
178Deep palmar crease (HP:0006191)1.52903545
179Overriding aorta (HP:0002623)1.52501474
180Germ cell neoplasia (HP:0100728)1.51159000
181Abnormal large intestine physiology (HP:0012700)1.51122426
182Onion bulb formation (HP:0003383)1.49967683
183Atrophic scars (HP:0001075)1.49188337
184Premature skin wrinkling (HP:0100678)1.49067673
185Thin ribs (HP:0000883)1.48766419
186Right ventricular cardiomyopathy (HP:0011663)1.48742928

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK128.50705273
2GRK54.04583066
3ERN13.99689764
4GRK63.88383717
5SMG13.88110015
6PRPF4B3.10732716
7IRAK32.99121604
8TYRO32.76259428
9TTK2.59676406
10CSF1R2.37794837
11GRK12.29624279
12FGFR42.20833856
13STK102.13142612
14MAP3K102.08297128
15TGFBR22.01378126
16ADRBK21.94619915
17WNK11.87414034
18MAPK71.84817322
19MST1R1.79153237
20EPHA21.74759579
21NME21.74143282
22MATK1.73293913
23CDK71.51736694
24ICK1.47765456
25NEK21.42256328
26MOS1.39087170
27ALK1.36482199
28TRIB31.36264492
29GRK71.36241546
30MAP2K31.31345449
31PAK41.31141921
32CAMK41.26830041
33CDC71.26256996
34CHEK21.22979023
35MARK21.22887545
36NTRK11.19698384
37KSR21.18665887
38EPHB11.13223470
39TAOK21.12874191
40PRKG21.12584320
41SCYL21.11667576
42PLK11.09951856
43MTOR1.04050881
44PTK61.03925798
45EEF2K1.03659315
46FGFR31.03573727
47CHEK11.01847810
48LATS20.98136168
49LMTK20.92541910
50MAP3K130.92462830
51IRAK20.90977683
52HIPK20.90449957
53CDC42BPA0.90313824
54RIPK10.89265463
55PDGFRA0.89049454
56PKN20.87132830
57MAP3K30.85473319
58AKT20.85062970
59MET0.84223209
60BMX0.84136492
61MAP3K10.82422589
62TTN0.82330413
63MAP3K70.82316637
64MAPK110.82007219
65TESK10.81760179
66PDK40.81093412
67PDK30.81093412
68NEK10.80344881
69RPS6KB20.78938012
70PRKD30.77962097
71MAP3K60.76945880
72MAP3K110.76319618
73TESK20.76168623
74PDPK10.76109607
75MAP2K40.75588355
76CDK40.74216874
77CDK60.72046021
78STK380.71705379
79AKT30.68737565
80CAMK1G0.68034496
81CSK0.67547740
82SIK30.67492384
83RPS6KA20.66612509
84ADRBK10.65507141
85CDK20.65080922
86SIK20.64228266
87RET0.62360389
88IRAK40.62119365
89ARAF0.59994670
90RPS6KL10.55989547
91RPS6KC10.55989547
92MAP3K140.55805719
93TBK10.55554135
94MAP3K90.55525180
95DDR20.55179077
96BRD40.55150633
97LATS10.54775830
98TAOK10.54627767
99PTK20.51692712
100BRAF0.50570181
101LRRK20.50315476
102MAP4K10.49854796
103ATM0.48971019
104MAP2K60.48215383
105ZAP700.47574121
106TYK20.45360350
107SIK10.44487191
108MAPK120.43771473
109RIPK40.43156428
110PRKCI0.42876143
111AURKB0.42107498
112CSNK1E0.40886557
113SGK30.39858855
114CDK90.39003958
115MAP2K20.38972721
116CDK10.38234461
117MAPK100.37963841
118WEE10.37804796
119AURKA0.37190309
120PDK10.36975883
121PDGFRB0.36973083
122CAMKK10.36724980
123PRKD20.35720796
124DMPK0.35137263
125PAK60.34589588
126MAP3K80.34541463
127PAK10.34534174
128DYRK1B0.34394658
129ERBB20.33577116
130PRKAA10.33388842
131ILK0.32610436
132PIM20.32526491
133PDK20.31744697
134GSK3B0.31430027
135MAPKAPK30.31412497
136RPS6KA60.30449375
137PAK20.30439576
138ATR0.30216542
139MAPK140.29926172
140RAF10.29690005
141MAP3K20.29611745
142RPS6KA10.29123657
143MELK0.29108983
144MAPKAPK20.28797000
145CAMK1D0.28120407
146MAPK10.27428959
147STK40.26649877
148STK30.25774154
149INSR0.22409806
150ITK0.21836145
151IGF1R0.20356117
152CSNK1D0.19094284
153PAK30.18909937
154BUB10.18873748
155RPS6KA30.17708920
156CDK150.17130826
157MAPK80.16905148

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.31123598
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006034.29693757
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.51855828
4Fructose and mannose metabolism_Homo sapiens_hsa000513.10699630
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.42137272
6Other glycan degradation_Homo sapiens_hsa005112.39288552
7mTOR signaling pathway_Homo sapiens_hsa041502.16795218
8RNA transport_Homo sapiens_hsa030132.14687483
9Galactose metabolism_Homo sapiens_hsa000521.97077558
10One carbon pool by folate_Homo sapiens_hsa006701.66610045
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.65270024
12Thyroid cancer_Homo sapiens_hsa052161.48303881
13DNA replication_Homo sapiens_hsa030301.47343508
14Cell cycle_Homo sapiens_hsa041101.47229083
15* mRNA surveillance pathway_Homo sapiens_hsa030151.46404852
16Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.45724913
17Fanconi anemia pathway_Homo sapiens_hsa034601.45711818
18Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.44602519
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.41935036
20Central carbon metabolism in cancer_Homo sapiens_hsa052301.35175290
21Cyanoamino acid metabolism_Homo sapiens_hsa004601.33104242
22Arachidonic acid metabolism_Homo sapiens_hsa005901.32696677
23Insulin signaling pathway_Homo sapiens_hsa049101.32280505
24Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.31884662
25Prion diseases_Homo sapiens_hsa050201.29358617
26Renal cell carcinoma_Homo sapiens_hsa052111.28643885
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.27130854
28Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.25017691
29Thyroid hormone signaling pathway_Homo sapiens_hsa049191.24076827
30Mismatch repair_Homo sapiens_hsa034301.23842141
31Linoleic acid metabolism_Homo sapiens_hsa005911.21759593
32ErbB signaling pathway_Homo sapiens_hsa040121.21300566
33Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.21035986
34MicroRNAs in cancer_Homo sapiens_hsa052061.18976765
35Basal cell carcinoma_Homo sapiens_hsa052171.17312091
36Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.16633165
37AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.11546860
38Non-small cell lung cancer_Homo sapiens_hsa052231.11022867
39Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.06674125
40Prostate cancer_Homo sapiens_hsa052151.06616969
41Transcriptional misregulation in cancer_Homo sapiens_hsa052021.06425101
42Inositol phosphate metabolism_Homo sapiens_hsa005621.05655603
43Phospholipase D signaling pathway_Homo sapiens_hsa040721.04113304
44Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.02735146
45Spliceosome_Homo sapiens_hsa030401.01816851
46Lysine degradation_Homo sapiens_hsa003101.01263220
47Acute myeloid leukemia_Homo sapiens_hsa052210.99262358
48Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.99126709
49Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.99116044
50Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.98152490
51Bladder cancer_Homo sapiens_hsa052190.97916376
52Hepatitis C_Homo sapiens_hsa051600.97364487
53Regulation of actin cytoskeleton_Homo sapiens_hsa048100.97246968
54p53 signaling pathway_Homo sapiens_hsa041150.95651488
55Notch signaling pathway_Homo sapiens_hsa043300.95607175
56Hepatitis B_Homo sapiens_hsa051610.95184061
57Hippo signaling pathway_Homo sapiens_hsa043900.95130818
58Hedgehog signaling pathway_Homo sapiens_hsa043400.94446036
59Base excision repair_Homo sapiens_hsa034100.89366925
60Estrogen signaling pathway_Homo sapiens_hsa049150.85926471
61Prolactin signaling pathway_Homo sapiens_hsa049170.85388296
62Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.85177999
63VEGF signaling pathway_Homo sapiens_hsa043700.83537234
64Pathways in cancer_Homo sapiens_hsa052000.83319384
65Proteoglycans in cancer_Homo sapiens_hsa052050.82581829
66RNA degradation_Homo sapiens_hsa030180.81114573
67AMPK signaling pathway_Homo sapiens_hsa041520.80407534
68Biosynthesis of amino acids_Homo sapiens_hsa012300.80374860
69Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.79944598
70Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.79862255
71Amoebiasis_Homo sapiens_hsa051460.79796553
72Choline metabolism in cancer_Homo sapiens_hsa052310.79499396
73Phosphatidylinositol signaling system_Homo sapiens_hsa040700.79031027
74Rap1 signaling pathway_Homo sapiens_hsa040150.77566103
75Pentose and glucuronate interconversions_Homo sapiens_hsa000400.76457542
76Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.76119207
77Shigellosis_Homo sapiens_hsa051310.75592617
78Arginine biosynthesis_Homo sapiens_hsa002200.74920955
79Longevity regulating pathway - mammal_Homo sapiens_hsa042110.74459475
80Small cell lung cancer_Homo sapiens_hsa052220.73795537
81Viral carcinogenesis_Homo sapiens_hsa052030.73791462
82Pentose phosphate pathway_Homo sapiens_hsa000300.73603280
83Adherens junction_Homo sapiens_hsa045200.72962399
84Toll-like receptor signaling pathway_Homo sapiens_hsa046200.71603283
85Sphingolipid signaling pathway_Homo sapiens_hsa040710.70377373
86HTLV-I infection_Homo sapiens_hsa051660.68153871
87Osteoclast differentiation_Homo sapiens_hsa043800.67806381
88Endocytosis_Homo sapiens_hsa041440.67617368
89Vibrio cholerae infection_Homo sapiens_hsa051100.66610736
90Glycosaminoglycan degradation_Homo sapiens_hsa005310.66486169
91TNF signaling pathway_Homo sapiens_hsa046680.65666926
92Influenza A_Homo sapiens_hsa051640.64932167
93Tight junction_Homo sapiens_hsa045300.64629562
94Dorso-ventral axis formation_Homo sapiens_hsa043200.64111330
952-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.62398388
96Carbon metabolism_Homo sapiens_hsa012000.62208125
97Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.61894657
98Homologous recombination_Homo sapiens_hsa034400.61872979
99Toxoplasmosis_Homo sapiens_hsa051450.61675792
100Chronic myeloid leukemia_Homo sapiens_hsa052200.60870625
101Glucagon signaling pathway_Homo sapiens_hsa049220.59948028
102Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.59533173
103Lysosome_Homo sapiens_hsa041420.59157618
104Pancreatic cancer_Homo sapiens_hsa052120.58749465
105Salmonella infection_Homo sapiens_hsa051320.58569586
106Colorectal cancer_Homo sapiens_hsa052100.58192662
107N-Glycan biosynthesis_Homo sapiens_hsa005100.58135924
108Wnt signaling pathway_Homo sapiens_hsa043100.57168579
109Apoptosis_Homo sapiens_hsa042100.57103033
110Selenocompound metabolism_Homo sapiens_hsa004500.56997449
111Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56968726
112Herpes simplex infection_Homo sapiens_hsa051680.56521575
113Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.56259310
114Glycerophospholipid metabolism_Homo sapiens_hsa005640.55319436
115Neurotrophin signaling pathway_Homo sapiens_hsa047220.55054086
116Endometrial cancer_Homo sapiens_hsa052130.54997120
117Oocyte meiosis_Homo sapiens_hsa041140.53753916
118Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.52912264
119ECM-receptor interaction_Homo sapiens_hsa045120.52715911
120Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52434587
121RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.51025840
122Insulin resistance_Homo sapiens_hsa049310.49618200
123Long-term potentiation_Homo sapiens_hsa047200.49445711
124Fatty acid biosynthesis_Homo sapiens_hsa000610.49393484
125Dilated cardiomyopathy_Homo sapiens_hsa054140.48106966
126Ovarian steroidogenesis_Homo sapiens_hsa049130.45939254
127B cell receptor signaling pathway_Homo sapiens_hsa046620.45841273
128FoxO signaling pathway_Homo sapiens_hsa040680.45498801
129Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.44553074
130Leukocyte transendothelial migration_Homo sapiens_hsa046700.44234829
131Adipocytokine signaling pathway_Homo sapiens_hsa049200.44035083
132Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43219201
133Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.42526850
134Focal adhesion_Homo sapiens_hsa045100.42079079
135Sulfur relay system_Homo sapiens_hsa041220.40646513
136Glioma_Homo sapiens_hsa052140.38869254
137T cell receptor signaling pathway_Homo sapiens_hsa046600.38354226
138Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.37371079
139HIF-1 signaling pathway_Homo sapiens_hsa040660.35725706
140GnRH signaling pathway_Homo sapiens_hsa049120.33988623
141MAPK signaling pathway_Homo sapiens_hsa040100.33617600

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