SMG6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a component of the telomerase ribonucleoprotein complex responsible for the replication and maintenance of chromosome ends. The encoded protein also plays a role in the nonsense-mediated mRNA decay (NMD) pathway, providing the endonuclease activity near the premature translation termination codon that is needed to initiate NMD. Alternatively spliced transcript variants encoding distinct protein isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic sister chromatid cohesion (GO:0007064)4.81781697
2nuclear pore complex assembly (GO:0051292)4.69339409
3nuclear pore organization (GO:0006999)4.25415072
4pre-miRNA processing (GO:0031054)4.12026657
5negative regulation of histone methylation (GO:0031061)4.02852333
6positive regulation of histone deacetylation (GO:0031065)3.89704144
7regulation of RNA export from nucleus (GO:0046831)3.82080722
8regulation of histone H3-K9 methylation (GO:0051570)3.74988375
9regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.74783677
10adherens junction assembly (GO:0034333)3.62493674
11cytoskeletal anchoring at plasma membrane (GO:0007016)3.62429636
12planar cell polarity pathway involved in neural tube closure (GO:0090179)3.58028914
13pore complex assembly (GO:0046931)3.57010743
14histone H3-K36 demethylation (GO:0070544)3.50604998
15NLS-bearing protein import into nucleus (GO:0006607)3.49160253
16peptidyl-lysine dimethylation (GO:0018027)3.48160230
17cell-substrate junction assembly (GO:0007044)3.46994205
18cell-substrate adherens junction assembly (GO:0007045)3.45378985
19focal adhesion assembly (GO:0048041)3.45378985
20histone H3-K9 demethylation (GO:0033169)3.42730927
21regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.32266047
22regulation of NFAT protein import into nucleus (GO:0051532)3.31258101
23definitive hemopoiesis (GO:0060216)3.25148609
24histone lysine demethylation (GO:0070076)3.24818225
25protein localization to endosome (GO:0036010)3.22230758
26antigen processing and presentation via MHC class Ib (GO:0002475)3.20943980
27monoubiquitinated protein deubiquitination (GO:0035520)3.17057369
28histone demethylation (GO:0016577)3.14385961
29mitotic chromosome condensation (GO:0007076)3.13414794
30gene silencing by RNA (GO:0031047)3.13283063
31regulation of nucleobase-containing compound transport (GO:0032239)3.12875580
32cytoplasmic mRNA processing body assembly (GO:0033962)3.11452253
33protein-DNA complex disassembly (GO:0032986)3.09632826
34nucleosome disassembly (GO:0006337)3.09632826
35glucocorticoid receptor signaling pathway (GO:0042921)3.08430477
36mRNA stabilization (GO:0048255)3.06662996
37RNA stabilization (GO:0043489)3.06662996
38semaphorin-plexin signaling pathway (GO:0071526)3.06144471
39skin morphogenesis (GO:0043589)3.04105032
40histone H3-K4 methylation (GO:0051568)3.02759111
41gene silencing (GO:0016458)3.00332739
42positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.98299910
43positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.98299910
44positive regulation of mitotic sister chromatid separation (GO:1901970)2.98299910
45histone H3-K9 methylation (GO:0051567)2.96262753
46negative regulation of DNA repair (GO:0045738)2.95058461
47genitalia morphogenesis (GO:0035112)2.94640760
48regulation of gamma-delta T cell differentiation (GO:0045586)2.93841196
49hemidesmosome assembly (GO:0031581)2.92005179
50positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.91926878
51regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.91926878
52regulation of DNA endoreduplication (GO:0032875)2.90075668
53insulin-like growth factor receptor signaling pathway (GO:0048009)2.89930728
54positive regulation of gamma-delta T cell activation (GO:0046645)2.88336862
55chromatin assembly (GO:0031497)2.87531723
56positive regulation of RNA splicing (GO:0033120)2.86800179
57sister chromatid segregation (GO:0000819)2.86793698
58dosage compensation (GO:0007549)2.85900016
59histone H4-K16 acetylation (GO:0043984)2.85570891
60positive regulation of blood vessel endothelial cell migration (GO:0043536)2.85329785
61negative regulation of translation, ncRNA-mediated (GO:0040033)2.84789594
62regulation of translation, ncRNA-mediated (GO:0045974)2.84789594
63negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.84789594
64histone H3-K9 modification (GO:0061647)2.84332299
65regulation of ARF protein signal transduction (GO:0032012)2.83564858
66interkinetic nuclear migration (GO:0022027)2.82865339
67protein demethylation (GO:0006482)2.82670856
68protein dealkylation (GO:0008214)2.82670856
69stress granule assembly (GO:0034063)2.82569387
70positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.82277405
71histone lysine methylation (GO:0034968)2.80626864
72negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.79695264
73heterochromatin organization (GO:0070828)2.78938001
74regulation of mRNA catabolic process (GO:0061013)2.78350235
75positive regulation of mRNA catabolic process (GO:0061014)2.75566551
76regulation of protein polyubiquitination (GO:1902914)2.75449611
77regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.73306014
78regulation of sister chromatid cohesion (GO:0007063)2.72534292
79stress fiber assembly (GO:0043149)2.71889090
80synaptonemal complex assembly (GO:0007130)2.71614752
81histone H3-K4 trimethylation (GO:0080182)2.70718991
82alternative mRNA splicing, via spliceosome (GO:0000380)2.68834217
83negative regulation of histone modification (GO:0031057)2.66382349
84positive regulation of protein deacetylation (GO:0090312)2.66166936
85negative regulation of cell size (GO:0045792)2.65088907
86regulation of translational fidelity (GO:0006450)2.62884385
87regulation of gamma-delta T cell activation (GO:0046643)2.62236662
88sister chromatid cohesion (GO:0007062)2.62195489
89peptidyl-lysine trimethylation (GO:0018023)2.61859734
90chromatin silencing (GO:0006342)2.61509454
91DNA topological change (GO:0006265)2.61471652
92regulation of extracellular matrix disassembly (GO:0010715)2.61001623
93negative regulation of fatty acid transport (GO:2000192)2.60652908
94embryonic retina morphogenesis in camera-type eye (GO:0060059)2.60039652
95protein heterotrimerization (GO:0070208)2.59692433
96atrioventricular valve morphogenesis (GO:0003181)2.58541425
97cortical actin cytoskeleton organization (GO:0030866)2.58532569
98basement membrane organization (GO:0071711)2.58326564
99synaptic vesicle docking involved in exocytosis (GO:0016081)2.58270499
100positive thymic T cell selection (GO:0045059)2.57472217
101protein localization to chromosome, centromeric region (GO:0071459)2.57319809
102histone H2A monoubiquitination (GO:0035518)2.57220294
103germ cell migration (GO:0008354)2.56269013
104negative regulation of mRNA metabolic process (GO:1903312)2.55936486
105regulation of mRNA stability (GO:0043488)2.54592773
106camera-type eye morphogenesis (GO:0048593)2.54195831
107positive regulation of hormone biosynthetic process (GO:0046886)2.54133368
108hypotonic response (GO:0006971)2.53860911
109nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.53588413
110paraxial mesoderm development (GO:0048339)2.51782203
111histone mRNA catabolic process (GO:0071044)2.51718083
112protein localization to kinetochore (GO:0034501)2.51182316
113regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.50954014
114positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.50954014
115vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.50767715
116peptidyl-lysine methylation (GO:0018022)2.50713826
117barbed-end actin filament capping (GO:0051016)2.49811385
118endothelial cell chemotaxis (GO:0035767)2.49402191
119protein targeting to plasma membrane (GO:0072661)2.49149589
120negative regulation of chromatin modification (GO:1903309)2.49139771
121endodermal cell differentiation (GO:0035987)2.48721465
122cell migration involved in heart development (GO:0060973)2.48529188
123collagen fibril organization (GO:0030199)2.48104234
124synaptonemal complex organization (GO:0070193)2.47985798
125DNA packaging (GO:0006323)2.47855120
126regulation of early endosome to late endosome transport (GO:2000641)2.45708024
127dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.45597861
128vascular endothelial growth factor signaling pathway (GO:0038084)2.44997491
129regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.44983923
130negative regulation of RNA splicing (GO:0033119)2.44199036
131translesion synthesis (GO:0019985)2.43947081
132mitotic nuclear envelope disassembly (GO:0007077)2.42586156
133DNA geometric change (GO:0032392)2.42261362
134DNA duplex unwinding (GO:0032508)2.42210377
135histone H4-K8 acetylation (GO:0043982)2.40454253
136histone H4-K5 acetylation (GO:0043981)2.40454253
137piRNA metabolic process (GO:0034587)2.40242061
138positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.39682531
139COPI coating of Golgi vesicle (GO:0048205)2.39364325
140Golgi transport vesicle coating (GO:0048200)2.39364325
141Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.38490782
142myoblast fusion (GO:0007520)2.36769133
143retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.36346931
144apoptotic process involved in morphogenesis (GO:0060561)2.36083750
145venous blood vessel morphogenesis (GO:0048845)2.35807125
146cortical cytoskeleton organization (GO:0030865)2.35317235
147syncytium formation by plasma membrane fusion (GO:0000768)2.35125276
148negative regulation of chondrocyte differentiation (GO:0032331)2.34833639
149regulation of glucose import in response to insulin stimulus (GO:2001273)2.34123694
150extracellular matrix assembly (GO:0085029)2.33376783
151eye morphogenesis (GO:0048592)2.32283900
152signal complex assembly (GO:0007172)2.29410696
153positive regulation of receptor recycling (GO:0001921)2.28911564
154negative regulation of anoikis (GO:2000811)2.28622508
155regulation of establishment of planar polarity (GO:0090175)2.28006347
156response to laminar fluid shear stress (GO:0034616)2.27360490
157embryonic process involved in female pregnancy (GO:0060136)2.27099426
158cell-cell junction maintenance (GO:0045217)2.25822608
159cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.25796619
160negative regulation of myotube differentiation (GO:0010832)2.25649044
161cell adhesion mediated by integrin (GO:0033627)2.24047121
162establishment of nucleus localization (GO:0040023)2.23611287
163protein retention in ER lumen (GO:0006621)2.22694353
164corticosteroid receptor signaling pathway (GO:0031958)2.22572302
165maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.21417117
166peripheral nervous system axon ensheathment (GO:0032292)2.21126019
167myelination in peripheral nervous system (GO:0022011)2.21126019
168epithelial cell-cell adhesion (GO:0090136)2.20989065
169cerebellar granule cell differentiation (GO:0021707)2.18979782
170positive regulation of myotube differentiation (GO:0010831)2.18404763
171regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.18146938
172regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.17195351
173blood vessel endothelial cell migration (GO:0043534)2.17068474
174cellular response to epidermal growth factor stimulus (GO:0071364)2.14821251
175neural tube development (GO:0021915)2.14670796
176substrate-dependent cell migration (GO:0006929)2.14198981
177positive regulation of epithelial to mesenchymal transition (GO:0010718)2.14086024
178actin cytoskeleton reorganization (GO:0031532)2.14070496
179regulation of p38MAPK cascade (GO:1900744)2.13918619
180G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.13460597
181convergent extension (GO:0060026)2.12503472
182hippo signaling (GO:0035329)2.11794541
183regulation of histone H3-K27 methylation (GO:0061085)2.11147255
184response to epidermal growth factor (GO:0070849)2.08175688
185pericardium development (GO:0060039)2.08105607
186regulation of ARF GTPase activity (GO:0032312)2.08094414
187endocytic recycling (GO:0032456)2.07940271
188cell migration involved in sprouting angiogenesis (GO:0002042)2.07404636
189coronary vasculature morphogenesis (GO:0060977)2.06905044

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.72919318
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.97282172
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.89538771
4MYC_22102868_ChIP-Seq_BL_Human3.75889354
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.63993486
6TP63_17297297_ChIP-ChIP_HaCaT_Human3.47455165
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.09138707
8TCF7_22412390_ChIP-Seq_EML_Mouse2.81500400
9MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.67388929
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.65729842
11SCL_19346495_ChIP-Seq_HPC-7_Human2.40707726
12THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.39918262
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.37539814
14TP63_19390658_ChIP-ChIP_HaCaT_Human2.33845719
15KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.22489597
16FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.21924176
17* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.19902217
18TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.14875037
19SALL1_21062744_ChIP-ChIP_HESCs_Human2.13541668
20ESR2_21235772_ChIP-Seq_MCF-7_Human2.08322127
21LXR_22292898_ChIP-Seq_THP-1_Human2.07392959
22BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.03870756
23KDM2B_26808549_Chip-Seq_DND41_Human1.99236353
24PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.96864546
25DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.95991872
26KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.94574466
27* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.92130515
28STAT6_21828071_ChIP-Seq_BEAS2B_Human1.92104791
29FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.88560095
30VDR_21846776_ChIP-Seq_THP-1_Human1.84561263
31TRIM28_21343339_ChIP-Seq_HEK293_Human1.81716395
32UTX_26944678_Chip-Seq_JUKART_Human1.79444804
33VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.78825516
34MYB_26560356_Chip-Seq_TH1_Human1.77216711
35RACK7_27058665_Chip-Seq_MCF-7_Human1.73764139
36EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.68608675
37TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.67768927
38TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.67258462
39MAF_26560356_Chip-Seq_TH1_Human1.64215478
40GATA1_22025678_ChIP-Seq_K562_Human1.61746421
41KDM2B_26808549_Chip-Seq_SUP-B15_Human1.60323932
42CIITA_25753668_ChIP-Seq_RAJI_Human1.60296957
43FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.58646337
44E2F1_21310950_ChIP-Seq_MCF-7_Human1.54315502
45FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.54145414
46PKCTHETA_26484144_Chip-Seq_BREAST_Human1.52708203
47ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.48073658
48NCOR1_26117541_ChIP-Seq_K562_Human1.47790621
49UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.46146145
50ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.44567748
51TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.43967001
52TP53_22127205_ChIP-Seq_IMR90_Human1.43161240
53KDM2B_26808549_Chip-Seq_JURKAT_Human1.42607578
54ZFP281_27345836_Chip-Seq_ESCs_Mouse1.42262040
55STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.41835386
56RUNX_20019798_ChIP-Seq_JUKART_Human1.40814503
57MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.40019005
58MYB_26560356_Chip-Seq_TH2_Human1.37921275
59DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.36194965
60PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.36025717
61HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.35535249
62DROSHA_22980978_ChIP-Seq_HELA_Human1.35230837
63SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.34811608
64* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.34249324
65EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33334935
66FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.31749201
67KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.30417878
68NFIB_24661679_ChIP-Seq_LUNG_Mouse1.28147075
69UBF1/2_26484160_Chip-Seq_HMECs_Human1.27156950
70E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.27096547
71SMC4_20622854_ChIP-Seq_HELA_Human1.26002365
72NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.25534663
73BRD4_27068464_Chip-Seq_AML-cells_Mouse1.25487274
74SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.25131713
75CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.23118752
76* TP53_23651856_ChIP-Seq_MEFs_Mouse1.22349688
77STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.22261962
78CTNNB1_20460455_ChIP-Seq_HCT116_Human1.22239927
79* SPI1_23127762_ChIP-Seq_K562_Human1.20731835
80CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.20166003
81CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.19847041
82ERG_21242973_ChIP-ChIP_JURKAT_Human1.18419321
83WT1_19549856_ChIP-ChIP_CCG9911_Human1.18147097
84CREB1_26743006_Chip-Seq_LNCaP_Human1.17838872
85RUNX1_22412390_ChIP-Seq_EML_Mouse1.17582610
86ELK3_25401928_ChIP-Seq_HUVEC_Human1.15277680
87HIF1A_21447827_ChIP-Seq_MCF-7_Human1.13875309
88* FOXA2_19822575_ChIP-Seq_HepG2_Human1.13527626
89NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.13221643
90* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11796988
91GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.11790041
92DNAJC2_21179169_ChIP-ChIP_NT2_Human1.11758008
93* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.11528822
94ZNF263_19887448_ChIP-Seq_K562_Human1.10485145
95GATA1_19941826_ChIP-Seq_K562_Human1.07599224
96TET1_21490601_ChIP-Seq_MESCs_Mouse1.07383614
97MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.06831275
98FOXO3_23340844_ChIP-Seq_DLD1_Human1.06659874
99GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04984681
100GATA1_19941827_ChIP-Seq_MEL_Mouse1.04889621
101VDR_24763502_ChIP-Seq_THP-1_Human1.04423617
102EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.04000268
103SMC1_22415368_ChIP-Seq_MEFs_Mouse1.03963117
104RARB_27405468_Chip-Seq_BRAIN_Mouse1.02854662
105AR_21909140_ChIP-Seq_LNCAP_Human1.02729070
106CLOCK_20551151_ChIP-Seq_293T_Human1.02667892
107IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.02538362
108RNF2_18974828_ChIP-Seq_MESCs_Mouse1.01924519
109EZH2_18974828_ChIP-Seq_MESCs_Mouse1.01924519
110PPARA_22158963_ChIP-Seq_LIVER_Mouse1.01425375
111SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.00484991
112SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.00484991
113P300_27058665_Chip-Seq_ZR-75-30cells_Human1.00286520
114ESR1_21235772_ChIP-Seq_MCF-7_Human0.99920484
115ESR1_20079471_ChIP-ChIP_T-47D_Human0.98747127
116WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98718058
117SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.98287190
118* BRD4_25478319_ChIP-Seq_HGPS_Human0.97997573
119RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.96778839
120CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.96605280
121ISL1_27105846_Chip-Seq_CPCs_Mouse0.96153839
122GATA2_21666600_ChIP-Seq_HMVEC_Human0.95995936
123KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.95832106
124* LXR_22158963_ChIP-Seq_LIVER_Mouse0.95373835
125RUNX1_27514584_Chip-Seq_MCF-7_Human0.95131675
126ZNF217_24962896_ChIP-Seq_MCF-7_Human0.94724007
127TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.94413279
128TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.94264456
129ATF3_27146783_Chip-Seq_COLON_Human0.94139007
130IRF8_22096565_ChIP-ChIP_GC-B_Human0.93917968
131SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.93770627
132ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.93770507
133RNF2_27304074_Chip-Seq_ESCs_Mouse0.93503351
134GATA6_25053715_ChIP-Seq_YYC3_Human0.93371219
135EZH2_22144423_ChIP-Seq_EOC_Human0.92933825
136ZFP281_18757296_ChIP-ChIP_E14_Mouse0.92329702
137CTCF_27219007_Chip-Seq_ERYTHROID_Human0.92219777
138SOX9_24532713_ChIP-Seq_HFSC_Mouse0.91748219
139CHD1_26751641_Chip-Seq_LNCaP_Human0.91571787
140ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91033470
141OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.90380731
142TBX20_22080862_ChIP-Seq_HEART_Mouse0.89923152
143TBX20_22328084_ChIP-Seq_HEART_Mouse0.89923152
144RING1B_27294783_Chip-Seq_NPCs_Mouse0.89046932
145SA1_27219007_Chip-Seq_ERYTHROID_Human0.89023024
146TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.88543036
147NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.87626156
148RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.87094508
149P68_20966046_ChIP-Seq_HELA_Human0.86059220
150WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.85733677
151NANOG_21062744_ChIP-ChIP_HESCs_Human0.84791996
152GATA2_22383799_ChIP-Seq_G1ME_Mouse0.84079916
153KDM2B_26808549_Chip-Seq_K562_Human0.83502158
154KDM5A_27292631_Chip-Seq_BREAST_Human0.83107411
155ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.81797635
156NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.81115499

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.95368269
2MP0008438_abnormal_cutaneous_collagen4.68788287
3MP0004272_abnormal_basement_membrane2.89045920
4MP0009278_abnormal_bone_marrow2.81489649
5MP0003279_aneurysm2.75393370
6MP0005257_abnormal_intraocular_pressure2.71788537
7MP0008877_abnormal_DNA_methylation2.64988029
8MP0001958_emphysema2.62466062
9MP0003091_abnormal_cell_migration2.60010080
10MP0004808_abnormal_hematopoietic_stem2.52262905
11MP0005275_abnormal_skin_tensile2.45499341
12MP0005503_abnormal_tendon_morphology2.40440879
13MP0005076_abnormal_cell_differentiation2.39531791
14MP0004858_abnormal_nervous_system2.38868130
15MP0010368_abnormal_lymphatic_system2.37381182
16MP0005409_darkened_coat_color2.27938229
17MP0003300_gastrointestinal_ulcer2.27694167
18MP0003705_abnormal_hypodermis_morpholog2.24519142
19MP0002396_abnormal_hematopoietic_system2.21710156
20MP0000751_myopathy2.19218569
21MP0010352_gastrointestinal_tract_polyps2.19149766
22MP0008961_abnormal_basal_metabolism2.03618043
23MP0010094_abnormal_chromosome_stability2.02895704
24MP0003787_abnormal_imprinting1.97730247
25MP0010030_abnormal_orbit_morphology1.89382510
26MP0008260_abnormal_autophagy1.87343140
27MP0004233_abnormal_muscle_weight1.81785231
28MP0003111_abnormal_nucleus_morphology1.79186468
29MP0002166_altered_tumor_susceptibility1.75667602
30MP0001545_abnormal_hematopoietic_system1.73551365
31MP0005397_hematopoietic_system_phenotyp1.73551365
32MP0010307_abnormal_tumor_latency1.67042533
33MP0000767_abnormal_smooth_muscle1.65057446
34MP0005670_abnormal_white_adipose1.64564536
35MP0008057_abnormal_DNA_replication1.63794740
36MP0001849_ear_inflammation1.59271789
37MP0004197_abnormal_fetal_growth/weight/1.57440417
38MP0003121_genomic_imprinting1.55004181
39MP0003045_fibrosis1.53591123
40MP0001348_abnormal_lacrimal_gland1.49973456
41MP0004264_abnormal_extraembryonic_tissu1.49307981
42MP0008007_abnormal_cellular_replicative1.48550413
43MP0002249_abnormal_larynx_morphology1.48337253
44MP0003763_abnormal_thymus_physiology1.48114409
45MP0009384_cardiac_valve_regurgitation1.46813898
46MP0002060_abnormal_skin_morphology1.46343086
47MP0003566_abnormal_cell_adhesion1.46019069
48MP0003077_abnormal_cell_cycle1.43880997
49MP0000703_abnormal_thymus_morphology1.42199740
50MP0009780_abnormal_chondrocyte_physiolo1.42069272
51MP0005365_abnormal_bile_salt1.40920396
52MP0003329_amyloid_beta_deposits1.40909883
53MP0002086_abnormal_extraembryonic_tissu1.39386261
54MP0000534_abnormal_ureter_morphology1.39360668
55MP0002653_abnormal_ependyma_morphology1.38437728
56MP0005174_abnormal_tail_pigmentation1.37852585
57MP0004859_abnormal_synaptic_plasticity1.37443543
58MP0002088_abnormal_embryonic_growth/wei1.33627409
59MP0003984_embryonic_growth_retardation1.32932490
60MP0002108_abnormal_muscle_morphology1.32392578
61MP0000371_diluted_coat_color1.32361780
62MP0009703_decreased_birth_body1.31871838
63MP0002928_abnormal_bile_duct1.31459231
64MP0003385_abnormal_body_wall1.30819202
65MP0005508_abnormal_skeleton_morphology1.30034491
66MP0003123_paternal_imprinting1.29278499
67MP0009672_abnormal_birth_weight1.28743426
68MP0005380_embryogenesis_phenotype1.28133349
69MP0001672_abnormal_embryogenesis/_devel1.28133349
70MP0002084_abnormal_developmental_patter1.28011442
71MP0001299_abnormal_eye_distance/1.27630001
72MP0002896_abnormal_bone_mineralization1.25167082
73MP0000759_abnormal_skeletal_muscle1.23956007
74MP0003567_abnormal_fetal_cardiomyocyte1.22571089
75MP0003252_abnormal_bile_duct1.22453266
76MP0001929_abnormal_gametogenesis1.19730875
77MP0008995_early_reproductive_senescence1.19114641
78MP0000350_abnormal_cell_proliferation1.18807492
79MP0003115_abnormal_respiratory_system1.18511588
80MP0001730_embryonic_growth_arrest1.17176204
81MP0001293_anophthalmia1.16335038
82MP0000733_abnormal_muscle_development1.15852497
83MP0004185_abnormal_adipocyte_glucose1.14985295
84MP0002398_abnormal_bone_marrow1.13948397
85MP0010630_abnormal_cardiac_muscle1.12462175
86MP0003942_abnormal_urinary_system1.12261819
87MP0001879_abnormal_lymphatic_vessel1.12210814
88MP0002877_abnormal_melanocyte_morpholog1.11432017
89MP0003453_abnormal_keratinocyte_physiol1.10951303
90MP0004087_abnormal_muscle_fiber1.10805091
91MP0002006_tumorigenesis1.09406168
92MP0003693_abnormal_embryo_hatching1.08797192
93MP0002089_abnormal_postnatal_growth/wei1.08232813
94MP0006138_congestive_heart_failure1.06613066
95MP0002210_abnormal_sex_determination1.06276950
96MP0005410_abnormal_fertilization1.06184403
97MP0005621_abnormal_cell_physiology1.05777329
98MP0000383_abnormal_hair_follicle1.05460411
99MP0002925_abnormal_cardiovascular_devel1.04672790
100MP0000566_synostosis1.04587772
101MP0003828_pulmonary_edema1.02649244
102MP0005451_abnormal_body_composition1.01473910
103MP0001697_abnormal_embryo_size1.01268679
104MP0002085_abnormal_embryonic_tissue1.00671274
105MP0009053_abnormal_anal_canal1.00420588
106MP0001915_intracranial_hemorrhage0.99870340
107MP0004510_myositis0.99625848
108MP0005058_abnormal_lysosome_morphology0.97515256
109MP0000762_abnormal_tongue_morphology0.97245475
110MP0005023_abnormal_wound_healing0.97194386
111MP0002092_abnormal_eye_morphology0.96798183
112MP0003698_abnormal_male_reproductive0.95136540
113MP0008058_abnormal_DNA_repair0.93812241
114MP0002009_preneoplasia0.93344206
115MP0001145_abnormal_male_reproductive0.93285308
116MP0004947_skin_inflammation0.92209580
117MP0000266_abnormal_heart_morphology0.92072551
118MP0003943_abnormal_hepatobiliary_system0.91828728
119MP0002116_abnormal_craniofacial_bone0.91550873
120MP0002722_abnormal_immune_system0.90949648
121MP0000747_muscle_weakness0.90504986
122MP0001614_abnormal_blood_vessel0.90400807
123MP0003634_abnormal_glial_cell0.90210451
124MP0003935_abnormal_craniofacial_develop0.89982052
125MP0002080_prenatal_lethality0.89135539
126MP0005666_abnormal_adipose_tissue0.88115565
127MP0000003_abnormal_adipose_tissue0.88098536
128MP0006054_spinal_hemorrhage0.87752300
129MP0002697_abnormal_eye_size0.87710106
130MP0000579_abnormal_nail_morphology0.86168942
131MP0000013_abnormal_adipose_tissue0.85399477
132MP0002139_abnormal_hepatobiliary_system0.83285687
133MP0002998_abnormal_bone_remodeling0.83274201
134MP0005464_abnormal_platelet_physiology0.82553232
135MP0009840_abnormal_foam_cell0.82540533
136MP0009250_abnormal_appendicular_skeleto0.82490169
137MP0000689_abnormal_spleen_morphology0.82103989
138MP0005623_abnormal_meninges_morphology0.80225328
139MP0002019_abnormal_tumor_incidence0.80130212
140MP0005375_adipose_tissue_phenotype0.79766766
141MP0004957_abnormal_blastocyst_morpholog0.78587815
142MP0001784_abnormal_fluid_regulation0.78580133
143MP0003868_abnormal_feces_composition0.78046618
144MP0002075_abnormal_coat/hair_pigmentati0.78032677
145MP0000653_abnormal_sex_gland0.77674184
146MP0000537_abnormal_urethra_morphology0.77324580
147MP0000432_abnormal_head_morphology0.77124953
148MP0001243_abnormal_dermal_layer0.76618192
149MP0005647_abnormal_sex_gland0.76324286
150MP0000750_abnormal_muscle_regeneration0.76168409
151MP0003890_abnormal_embryonic-extraembry0.75292940
152MP0002128_abnormal_blood_circulation0.74963980
153MP0002114_abnormal_axial_skeleton0.74887914
154MP0000428_abnormal_craniofacial_morphol0.74637295
155MP0010678_abnormal_skin_adnexa0.73689166
156MP0002933_joint_inflammation0.73163531
157MP0004084_abnormal_cardiac_muscle0.71017643
158MP0003950_abnormal_plasma_membrane0.70920031
159MP0000313_abnormal_cell_death0.70246403
160MP0003172_abnormal_lysosome_physiology0.69843846
161MP0002932_abnormal_joint_morphology0.66723661
162MP0000778_abnormal_nervous_system0.66281698
163MP0000749_muscle_degeneration0.65731832
164MP0002113_abnormal_skeleton_development0.65703287
165MP0000462_abnormal_digestive_system0.65657813
166MP0001175_abnormal_lung_morphology0.65100413
167MP0005388_respiratory_system_phenotype0.64776994
168MP0002133_abnormal_respiratory_system0.64776994
169MP0004036_abnormal_muscle_relaxation0.64242512
170MP0004130_abnormal_muscle_cell0.63853303

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)4.42863239
2Premature rupture of membranes (HP:0001788)4.16095484
3Volvulus (HP:0002580)3.78158137
4Long eyelashes (HP:0000527)3.18930028
5Obstructive sleep apnea (HP:0002870)3.13791680
6Hyperacusis (HP:0010780)3.11283706
7Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.03485341
8Short 4th metacarpal (HP:0010044)3.03485341
9Cerebral aneurysm (HP:0004944)3.02538342
10Vascular tortuosity (HP:0004948)2.99492733
11Aortic dissection (HP:0002647)2.98570541
12Arterial tortuosity (HP:0005116)2.92335684
13Renovascular hypertension (HP:0100817)2.82601746
14Atrophic scars (HP:0001075)2.79227059
15Heterotopia (HP:0002282)2.78915069
16Broad face (HP:0000283)2.73541768
17Neonatal short-limb short stature (HP:0008921)2.72774280
18Macroorchidism (HP:0000053)2.71333335
19Abnormality of the lower motor neuron (HP:0002366)2.69707450
20Increased nuchal translucency (HP:0010880)2.66888480
21Cervical subluxation (HP:0003308)2.64726191
22Truncal obesity (HP:0001956)2.62387255
23Aortic aneurysm (HP:0004942)2.60735254
24Absent frontal sinuses (HP:0002688)2.56086678
25Obsessive-compulsive behavior (HP:0000722)2.52795318
26Elfin facies (HP:0004428)2.48851831
27Spinal rigidity (HP:0003306)2.47455653
28Narrow palate (HP:0000189)2.46527387
29Trigonocephaly (HP:0000243)2.45019168
30Urethral obstruction (HP:0000796)2.42820234
31Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.40141405
32Disproportionate tall stature (HP:0001519)2.39781937
33Abnormality of the 4th metacarpal (HP:0010012)2.38992532
34Prominent nose (HP:0000448)2.37495936
35Wormian bones (HP:0002645)2.36593258
36Increased connective tissue (HP:0009025)2.34973266
37Broad metatarsal (HP:0001783)2.34698245
38Ependymoma (HP:0002888)2.34281662
39Long palpebral fissure (HP:0000637)2.34171265
40Mitral regurgitation (HP:0001653)2.33387873
41Increased variability in muscle fiber diameter (HP:0003557)2.30623347
42Renal duplication (HP:0000075)2.29469809
43Fragile skin (HP:0001030)2.28528828
44Broad palm (HP:0001169)2.27256043
45High pitched voice (HP:0001620)2.24539646
46Genu recurvatum (HP:0002816)2.24419158
47Upper limb amyotrophy (HP:0009129)2.23854163
48Distal upper limb amyotrophy (HP:0007149)2.23854163
49Joint laxity (HP:0001388)2.22695750
50Thin ribs (HP:0000883)2.20841248
51Syringomyelia (HP:0003396)2.20134596
52Spinal cord lesions (HP:0100561)2.20134596
53Type 1 muscle fiber predominance (HP:0003803)2.19129808
54Subacute progressive viral hepatitis (HP:0006572)2.18142452
55Aneurysm (HP:0002617)2.17192998
56Blue sclerae (HP:0000592)2.14627426
57Neoplasm of the oral cavity (HP:0100649)2.13880755
58Nasal polyposis (HP:0100582)2.12124556
59Bronchomalacia (HP:0002780)2.11511037
60Dilatation of the ascending aorta (HP:0005111)2.11100053
61Overgrowth (HP:0001548)2.09979603
62Supernumerary ribs (HP:0005815)2.09686790
63Dysmetric saccades (HP:0000641)2.09560792
64Turricephaly (HP:0000262)2.09331981
65Soft skin (HP:0000977)2.07920351
66Hypoplastic labia majora (HP:0000059)2.03402056
67Natal tooth (HP:0000695)2.02829178
68Low anterior hairline (HP:0000294)2.02197400
69Distal lower limb amyotrophy (HP:0008944)2.02109203
70Rectal prolapse (HP:0002035)2.02058544
71Deep philtrum (HP:0002002)2.01037137
72Dislocated radial head (HP:0003083)2.00368916
73Wide anterior fontanel (HP:0000260)2.00313713
74Abnormality of the astrocytes (HP:0100707)2.00313566
75Astrocytoma (HP:0009592)2.00313566
76Abnormality of dentin (HP:0010299)2.00282279
77Flat acetabular roof (HP:0003180)2.00272214
78Insomnia (HP:0100785)1.98629680
79Pseudobulbar signs (HP:0002200)1.98512257
80Mild short stature (HP:0003502)1.96768766
81Abnormality of the radial head (HP:0003995)1.96481379
82Abnormality of the distal phalanx of the thumb (HP:0009617)1.95122795
83Abnormality of skeletal muscle fiber size (HP:0012084)1.93220848
84Hyperextensible skin (HP:0000974)1.92942235
85Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.91688354
86Persistence of primary teeth (HP:0006335)1.91571763
87Bowel diverticulosis (HP:0005222)1.91222398
88Hypoplasia of the thymus (HP:0000778)1.90949299
89Biconcave vertebral bodies (HP:0004586)1.90395223
90Smooth philtrum (HP:0000319)1.90245180
91Lower limb amyotrophy (HP:0007210)1.89770018
92Mildly elevated creatine phosphokinase (HP:0008180)1.88781761
93Hand muscle atrophy (HP:0009130)1.86993045
94Mitral valve prolapse (HP:0001634)1.86957149
95Cutis marmorata (HP:0000965)1.85681094
96Neoplasm of the heart (HP:0100544)1.85389329
97Abnormality of the nasal mucosa (HP:0000433)1.85150591
98Arnold-Chiari malformation (HP:0002308)1.84862010
99Abnormality of the epiphyses of the hand (HP:0005924)1.84673735
100Advanced eruption of teeth (HP:0006288)1.83702346
101Recurrent bronchitis (HP:0002837)1.83639198
102Vertebral compression fractures (HP:0002953)1.83462539
103Abnormality of the labia majora (HP:0012881)1.83278232
104Sandal gap (HP:0001852)1.83189325
105Flat cornea (HP:0007720)1.82590462
106Ectopic kidney (HP:0000086)1.81743339
107Sparse lateral eyebrow (HP:0005338)1.81364783
108Achilles tendon contracture (HP:0001771)1.81357511
109Acute myeloid leukemia (HP:0004808)1.80401728
110Spondylolisthesis (HP:0003302)1.80127103
111Thick eyebrow (HP:0000574)1.79980980
112Enlarged penis (HP:0000040)1.79374242
113Anal stenosis (HP:0002025)1.78547523
114Centrally nucleated skeletal muscle fibers (HP:0003687)1.76532838
115Abnormality of the intervertebral disk (HP:0005108)1.75617986
116Short nail (HP:0001799)1.75374262
117Camptodactyly of toe (HP:0001836)1.72414755
118Deviation of the thumb (HP:0009603)1.71392155
119Supernumerary bones of the axial skeleton (HP:0009144)1.71121138
120Medulloblastoma (HP:0002885)1.70712719
121Hypoplasia of the iris (HP:0007676)1.69895700
122Proximal placement of thumb (HP:0009623)1.69512349
123Slender build (HP:0001533)1.69338573
124Lip pit (HP:0100267)1.69314564
125Skin tags (HP:0010609)1.69131517
126Lymphangioma (HP:0100764)1.68637156
127Biliary tract neoplasm (HP:0100574)1.65914595
128Malignant gastrointestinal tract tumors (HP:0006749)1.65131795
129Gastrointestinal carcinoma (HP:0002672)1.65131795
130Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.64969703
131Hematochezia (HP:0002573)1.64703518
132Shallow orbits (HP:0000586)1.64425783
133Ankle contracture (HP:0006466)1.63874720
134Aortic regurgitation (HP:0001659)1.63378995
135Thin bony cortex (HP:0002753)1.63216882
136Bicuspid aortic valve (HP:0001647)1.63011409
137Broad thumb (HP:0011304)1.62960210
138Papillary thyroid carcinoma (HP:0002895)1.62391792
139Vertebral arch anomaly (HP:0008438)1.61693848
140Glioma (HP:0009733)1.61457291
141Protrusio acetabuli (HP:0003179)1.61376623
142Hypoventilation (HP:0002791)1.60091477
143Abnormality of the humeroradial joint (HP:0100744)1.59880312
144Neurofibrillary tangles (HP:0002185)1.58606352
145Difficulty climbing stairs (HP:0003551)1.58292268
146Basal cell carcinoma (HP:0002671)1.57851079
147Abnormality of the phalanges of the hallux (HP:0010057)1.57656098
148T lymphocytopenia (HP:0005403)1.57652279
149Synophrys (HP:0000664)1.57360802
150Bladder diverticulum (HP:0000015)1.57096749
151Back pain (HP:0003418)1.56466240
152Long toe (HP:0010511)1.56358900
153Precocious puberty (HP:0000826)1.56344464
154Osteolytic defects of the phalanges of the hand (HP:0009771)1.56191203
155Osteolytic defects of the hand bones (HP:0009699)1.56191203
156Aplasia involving bones of the extremities (HP:0009825)1.56084285
157Aplasia involving bones of the upper limbs (HP:0009823)1.56084285
158Aplasia of the phalanges of the hand (HP:0009802)1.56084285
159Overriding aorta (HP:0002623)1.55937310
160Ulnar bowing (HP:0003031)1.55380178
161Cerebral inclusion bodies (HP:0100314)1.55003428
162Broad long bones (HP:0005622)1.54946395
163Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.53273089
164Pointed chin (HP:0000307)1.52881993
165Neoplasm of striated muscle (HP:0009728)1.51265072
166Colon cancer (HP:0003003)1.51134770
167Abnormality of the Achilles tendon (HP:0005109)1.50975105
168Abnormality of the diencephalon (HP:0010662)1.50437713
169Skull defect (HP:0001362)1.49771494
170Acute lymphatic leukemia (HP:0006721)1.49660621
171IgM deficiency (HP:0002850)1.49609748
172Abnormality of the sella turcica (HP:0002679)1.47994337
173Selective tooth agenesis (HP:0001592)1.47464661
174Limited elbow extension (HP:0001377)1.47255813

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.56832988
2EEF2K3.53821391
3BRD43.15512782
4MAP3K102.97384777
5PRPF4B2.89806664
6CAMK1G2.39218742
7SMG12.34270882
8LATS12.30305734
9NEK22.22419857
10CDC72.19929529
11CAMK1D2.19818108
12SIK11.96810826
13AKT31.87696842
14TRIB31.82410057
15FGFR41.77603865
16PDGFRA1.70676015
17PKN21.67061070
18MAP4K11.64513251
19PTK21.56355867
20ERN11.56212018
21FGFR31.53982449
22LATS21.53240217
23ICK1.52600200
24RIPK11.52381055
25EPHB11.51030018
26MTOR1.47049076
27CDK61.46705336
28PTK61.43727939
29NTRK11.43383005
30SIK21.33456937
31TTN1.27366260
32STK31.26703389
33CDK91.25612515
34FGFR21.23955175
35TGFBR21.22310484
36MAP3K131.21270003
37PDK31.17374777
38PDK41.17374777
39TAOK31.16387733
40CDK41.14330586
41STK101.13848943
42ATR1.12449978
43PDGFRB1.10701379
44NEK91.09949904
45RPS6KA21.06586428
46MAP3K71.04181149
47EPHB21.02118882
48PASK1.01627910
49TYRO31.01184661
50KSR21.00641308
51SGK30.99533973
52ALK0.96147192
53STK40.96029126
54PRKD30.95795237
55RPS6KB20.92907502
56TNK20.89398626
57CHUK0.89149542
58JAK10.87601191
59PAK60.86493170
60PAK20.86004797
61MAP2K30.84751865
62MET0.82352319
63BMX0.81896778
64MAP3K30.81710289
65TXK0.81617443
66BTK0.80850455
67CAMKK10.80341899
68CHEK10.79741093
69CDK70.79489785
70EPHA20.78862024
71SGK4940.78561057
72SGK2230.78561057
73JAK30.78471337
74ITK0.78326591
75MAP3K60.77013160
76ATM0.73820608
77CSF1R0.72334785
78ARAF0.72099780
79PNCK0.70589532
80FGFR10.70561020
81HCK0.68962119
82NUAK10.68526686
83RPS6KL10.65722565
84RPS6KC10.65722565
85MELK0.65513182
86MOS0.65039352
87LMTK20.64363756
88TGFBR10.63281536
89TTK0.62673817
90CDK20.62297307
91PIM10.61457963
92ROCK20.61238232
93PDPK10.60612975
94BRAF0.59588508
95NEK10.59302526
96CDC42BPA0.58755100
97HIPK20.58561861
98MARK10.57195355
99DMPK0.56666012
100CAMK40.54865703
101MAPK100.54523223
102PRKD20.53750743
103AURKB0.52965271
104DDR20.52921156
105MAPK140.51927052
106SRPK10.51143387
107NTRK20.50904928
108MARK20.50736618
109RPS6KA40.50668686
110LRRK20.50627022
111DYRK1B0.50238847
112SGK20.49865365
113ZAP700.49784895
114STK380.49354774
115ERBB20.49326949
116JAK20.49298285
117MAPK10.48771660
118MAP3K90.48571644
119CHEK20.47925131
120TRPM70.47448436
121PRKAA10.47278601
122PRKCH0.46795063
123RPS6KA60.46607175
124MAPK110.46154048
125CDK10.45715239
126EPHA30.44683967
127MAPK70.44498182
128PAK40.44314859
129RPS6KB10.43826344
130WNK10.43447164
131RET0.43094018
132MAPK150.42206809
133GRK60.42106439
134PRKDC0.41583319
135MKNK20.41515877
136TAOK10.41362681
137PIM20.41346664
138TAOK20.41015063
139MYLK0.40335845
140MAP3K10.39101371
141MAPK120.36488403
142ROCK10.36440771
143KSR10.35533215
144TESK10.33750674
145PRKD10.33201898
146UHMK10.31955817
147MAPK80.31122050
148MAP3K20.30121335
149IRAK30.28656392

Predicted pathways (KEGG)

RankGene SetZ-score
1Lysine degradation_Homo sapiens_hsa003102.80838977
2Nitrogen metabolism_Homo sapiens_hsa009101.72683766
3Chronic myeloid leukemia_Homo sapiens_hsa052201.71438968
4Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.66242358
5mTOR signaling pathway_Homo sapiens_hsa041501.53487168
6Primary immunodeficiency_Homo sapiens_hsa053401.50015218
7Thyroid hormone signaling pathway_Homo sapiens_hsa049191.49151008
8* mRNA surveillance pathway_Homo sapiens_hsa030151.45356531
9Notch signaling pathway_Homo sapiens_hsa043301.44246830
10Renal cell carcinoma_Homo sapiens_hsa052111.39298813
11MicroRNAs in cancer_Homo sapiens_hsa052061.37761357
12B cell receptor signaling pathway_Homo sapiens_hsa046621.37039876
13Transcriptional misregulation in cancer_Homo sapiens_hsa052021.35238718
14Adherens junction_Homo sapiens_hsa045201.31533608
15Non-small cell lung cancer_Homo sapiens_hsa052231.30162635
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.29840319
17Small cell lung cancer_Homo sapiens_hsa052221.29170955
18Insulin resistance_Homo sapiens_hsa049311.28716535
19Selenocompound metabolism_Homo sapiens_hsa004501.28577809
20Phospholipase D signaling pathway_Homo sapiens_hsa040721.25571098
21HTLV-I infection_Homo sapiens_hsa051661.24765767
22Amoebiasis_Homo sapiens_hsa051461.18844218
23Dorso-ventral axis formation_Homo sapiens_hsa043201.18387252
24Thyroid cancer_Homo sapiens_hsa052161.18364327
25Cell cycle_Homo sapiens_hsa041101.18287938
26T cell receptor signaling pathway_Homo sapiens_hsa046601.16500813
27Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.15946012
28Non-homologous end-joining_Homo sapiens_hsa034501.15879108
29GnRH signaling pathway_Homo sapiens_hsa049121.15019796
30Glucagon signaling pathway_Homo sapiens_hsa049221.14728100
31Long-term potentiation_Homo sapiens_hsa047201.14059221
32Acute myeloid leukemia_Homo sapiens_hsa052211.10559893
33Dilated cardiomyopathy_Homo sapiens_hsa054141.10552102
34Basal cell carcinoma_Homo sapiens_hsa052171.10462854
35Viral carcinogenesis_Homo sapiens_hsa052031.10020430
36Longevity regulating pathway - mammal_Homo sapiens_hsa042111.09736323
37Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.08907780
38Proteoglycans in cancer_Homo sapiens_hsa052051.08539475
39Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.07971324
40Melanogenesis_Homo sapiens_hsa049161.06639064
41Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.05950900
42Endometrial cancer_Homo sapiens_hsa052131.05309468
43Prion diseases_Homo sapiens_hsa050201.04954714
44Fanconi anemia pathway_Homo sapiens_hsa034601.04330403
45Antigen processing and presentation_Homo sapiens_hsa046121.03704631
46Colorectal cancer_Homo sapiens_hsa052101.02872022
47Pancreatic cancer_Homo sapiens_hsa052121.01344627
48Regulation of actin cytoskeleton_Homo sapiens_hsa048101.01290904
49Axon guidance_Homo sapiens_hsa043600.99425812
50Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.99100238
51Type II diabetes mellitus_Homo sapiens_hsa049300.98991707
52Systemic lupus erythematosus_Homo sapiens_hsa053220.98091669
53Base excision repair_Homo sapiens_hsa034100.95651950
54Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.94469891
55AMPK signaling pathway_Homo sapiens_hsa041520.94416545
56Focal adhesion_Homo sapiens_hsa045100.94355573
57RNA transport_Homo sapiens_hsa030130.93212238
58Gap junction_Homo sapiens_hsa045400.92080314
59NF-kappa B signaling pathway_Homo sapiens_hsa040640.91884548
60Carbohydrate digestion and absorption_Homo sapiens_hsa049730.91868675
61ABC transporters_Homo sapiens_hsa020100.91414551
62Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.90639800
63Tight junction_Homo sapiens_hsa045300.89929687
64Phosphatidylinositol signaling system_Homo sapiens_hsa040700.89672276
65Hepatitis B_Homo sapiens_hsa051610.87543752
66Glycosaminoglycan degradation_Homo sapiens_hsa005310.87350702
67Platelet activation_Homo sapiens_hsa046110.87241582
68Glioma_Homo sapiens_hsa052140.87212467
69FoxO signaling pathway_Homo sapiens_hsa040680.86851212
70Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.86838234
71One carbon pool by folate_Homo sapiens_hsa006700.86579780
72Central carbon metabolism in cancer_Homo sapiens_hsa052300.86501919
73AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.86262450
74Insulin signaling pathway_Homo sapiens_hsa049100.86220467
75Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.85379172
76Neurotrophin signaling pathway_Homo sapiens_hsa047220.84210570
77Prostate cancer_Homo sapiens_hsa052150.83721870
78Osteoclast differentiation_Homo sapiens_hsa043800.83620321
79Spliceosome_Homo sapiens_hsa030400.83609449
80Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.83219345
81Inositol phosphate metabolism_Homo sapiens_hsa005620.82711794
82Viral myocarditis_Homo sapiens_hsa054160.82107462
83Sphingolipid signaling pathway_Homo sapiens_hsa040710.81666433
84Herpes simplex infection_Homo sapiens_hsa051680.81339974
85Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.79461886
86Endocytosis_Homo sapiens_hsa041440.79444122
87Other glycan degradation_Homo sapiens_hsa005110.79430261
88Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.78993628
89PI3K-Akt signaling pathway_Homo sapiens_hsa041510.78914022
90MAPK signaling pathway_Homo sapiens_hsa040100.77182701
91Hepatitis C_Homo sapiens_hsa051600.76783711
92HIF-1 signaling pathway_Homo sapiens_hsa040660.74997966
93Melanoma_Homo sapiens_hsa052180.74878165
94Prolactin signaling pathway_Homo sapiens_hsa049170.73423358
95Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.73217279
96Jak-STAT signaling pathway_Homo sapiens_hsa046300.73164054
97Wnt signaling pathway_Homo sapiens_hsa043100.72871554
98Toxoplasmosis_Homo sapiens_hsa051450.72562419
99Measles_Homo sapiens_hsa051620.72253419
100ECM-receptor interaction_Homo sapiens_hsa045120.71981873
101Hippo signaling pathway_Homo sapiens_hsa043900.71387471
102Pathways in cancer_Homo sapiens_hsa052000.70747370
103Estrogen signaling pathway_Homo sapiens_hsa049150.68180237
104Caffeine metabolism_Homo sapiens_hsa002320.67755121
105Cholinergic synapse_Homo sapiens_hsa047250.67119679
106Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.67025357
107Oxytocin signaling pathway_Homo sapiens_hsa049210.66082630
108Leukocyte transendothelial migration_Homo sapiens_hsa046700.63669835
109TNF signaling pathway_Homo sapiens_hsa046680.63244428
110Protein digestion and absorption_Homo sapiens_hsa049740.63134211
111Hedgehog signaling pathway_Homo sapiens_hsa043400.63019268
112Gastric acid secretion_Homo sapiens_hsa049710.63012106
113VEGF signaling pathway_Homo sapiens_hsa043700.62935602
114Ras signaling pathway_Homo sapiens_hsa040140.62513970
115Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.62275538
116p53 signaling pathway_Homo sapiens_hsa041150.62012174
117TGF-beta signaling pathway_Homo sapiens_hsa043500.61425709
118Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.61334542
119cAMP signaling pathway_Homo sapiens_hsa040240.60246460
120Influenza A_Homo sapiens_hsa051640.60243305
121cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60186336
122Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.59389794
123ErbB signaling pathway_Homo sapiens_hsa040120.59356226
124Thyroid hormone synthesis_Homo sapiens_hsa049180.58936514
125Arginine biosynthesis_Homo sapiens_hsa002200.56790275
126Bile secretion_Homo sapiens_hsa049760.56412796
127Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56082594
128Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.55611476
129Adipocytokine signaling pathway_Homo sapiens_hsa049200.55248418
130Aldosterone synthesis and secretion_Homo sapiens_hsa049250.53943024
131Fatty acid degradation_Homo sapiens_hsa000710.53810896
132Bladder cancer_Homo sapiens_hsa052190.52739912
133Tryptophan metabolism_Homo sapiens_hsa003800.52310964
134Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.51642579
135Apoptosis_Homo sapiens_hsa042100.50096285
136Fatty acid biosynthesis_Homo sapiens_hsa000610.49552200
137Rap1 signaling pathway_Homo sapiens_hsa040150.48868040
138Complement and coagulation cascades_Homo sapiens_hsa046100.48503104
139Choline metabolism in cancer_Homo sapiens_hsa052310.47441013

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »