SMG7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is essential for nonsense-mediated mRNA decay (NMD); a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. The mRNA decay complex consists, in part, of this protein along with proteins SMG5 and UPF1. The N-terminal domain of this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex. This protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts. Alternative splicing results in multiple transcript variants encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.97226396
2nuclear pore organization (GO:0006999)5.48051272
3regulation of histone H3-K27 methylation (GO:0061085)5.10034416
4regulation of RNA export from nucleus (GO:0046831)4.83631229
5pore complex assembly (GO:0046931)4.69654850
6regulation of nucleobase-containing compound transport (GO:0032239)4.62845518
7dosage compensation (GO:0007549)4.01276826
8pre-miRNA processing (GO:0031054)3.96901821
9mitotic sister chromatid cohesion (GO:0007064)3.93184678
10negative regulation of erythrocyte differentiation (GO:0045647)3.72343494
11histone H4-K12 acetylation (GO:0043983)3.68674724
12positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.55243143
13positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.55243143
14positive regulation of mitotic sister chromatid separation (GO:1901970)3.55243143
153-UTR-mediated mRNA stabilization (GO:0070935)3.54410066
16regulation of nuclear cell cycle DNA replication (GO:0033262)3.54040694
17COPI coating of Golgi vesicle (GO:0048205)3.52889287
18Golgi transport vesicle coating (GO:0048200)3.52889287
19regulation of DNA endoreduplication (GO:0032875)3.44248978
20negative regulation of translation, ncRNA-mediated (GO:0040033)3.38848698
21regulation of translation, ncRNA-mediated (GO:0045974)3.38848698
22negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.38848698
23spliceosomal tri-snRNP complex assembly (GO:0000244)3.31599904
24negative regulation of DNA-dependent DNA replication (GO:2000104)3.28686770
25negative regulation of histone methylation (GO:0031061)3.27880017
26epithelial cell differentiation involved in prostate gland development (GO:0060742)3.24286369
27intracellular estrogen receptor signaling pathway (GO:0030520)3.23222873
28histone H3-K4 methylation (GO:0051568)3.22707112
29regulation of NFAT protein import into nucleus (GO:0051532)3.14092571
30regulation of protein polyubiquitination (GO:1902914)3.11164806
31histone H3-K36 demethylation (GO:0070544)3.07791164
32cytoskeletal anchoring at plasma membrane (GO:0007016)3.05937364
33protein export from nucleus (GO:0006611)3.04544567
34mitotic nuclear envelope disassembly (GO:0007077)3.04277784
35regulation of histone H3-K9 methylation (GO:0051570)3.03192541
36sister chromatid cohesion (GO:0007062)3.00892388
37trophectodermal cell differentiation (GO:0001829)2.98197024
38regulation of helicase activity (GO:0051095)2.98177578
39histone H3-K9 methylation (GO:0051567)2.97933465
40DNA double-strand break processing (GO:0000729)2.97250777
41histone demethylation (GO:0016577)2.94994124
42histone lysine demethylation (GO:0070076)2.93462242
43regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.91929787
44glucocorticoid receptor signaling pathway (GO:0042921)2.91112216
45positive regulation of keratinocyte differentiation (GO:0045618)2.88377328
46DNA unwinding involved in DNA replication (GO:0006268)2.88279445
47regulation of posttranscriptional gene silencing (GO:0060147)2.87433297
48regulation of gene silencing by miRNA (GO:0060964)2.87433297
49regulation of gene silencing by RNA (GO:0060966)2.87433297
50histone mRNA catabolic process (GO:0071044)2.87265054
51positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.86125088
52regulation of centriole replication (GO:0046599)2.84708469
53chromosome condensation (GO:0030261)2.84692603
54somatic diversification of immune receptors via somatic mutation (GO:0002566)2.83772580
55somatic hypermutation of immunoglobulin genes (GO:0016446)2.83772580
56membrane disassembly (GO:0030397)2.82793866
57nuclear envelope disassembly (GO:0051081)2.82793866
58rRNA catabolic process (GO:0016075)2.82565019
59cytoplasmic mRNA processing body assembly (GO:0033962)2.80250369
60histone H3-K9 demethylation (GO:0033169)2.76901722
61response to muramyl dipeptide (GO:0032495)2.76499625
62histone H3-K4 trimethylation (GO:0080182)2.75891663
63histone H4 deacetylation (GO:0070933)2.71934068
64protein dealkylation (GO:0008214)2.71622709
65protein demethylation (GO:0006482)2.71622709
66sister chromatid segregation (GO:0000819)2.70671605
67regulation of early endosome to late endosome transport (GO:2000641)2.70487055
68histone lysine methylation (GO:0034968)2.70122209
69regulation of histone methylation (GO:0031060)2.69583978
70regulation of ARF protein signal transduction (GO:0032012)2.68788313
71response to epidermal growth factor (GO:0070849)2.68715708
72stress granule assembly (GO:0034063)2.68365337
73replicative senescence (GO:0090399)2.68149364
74embryonic process involved in female pregnancy (GO:0060136)2.66388495
75negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.65774571
76activation of Rac GTPase activity (GO:0032863)2.64370548
77cellular response to epidermal growth factor stimulus (GO:0071364)2.61725167
78histone H4-K8 acetylation (GO:0043982)2.61077522
79histone H4-K5 acetylation (GO:0043981)2.61077522
80meiotic chromosome segregation (GO:0045132)2.60288320
81protein K6-linked ubiquitination (GO:0085020)2.59758924
82histone H3-K9 modification (GO:0061647)2.58939291
83protein localization to kinetochore (GO:0034501)2.58908145
84retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.58888705
85G1 DNA damage checkpoint (GO:0044783)2.58698516
86focal adhesion assembly (GO:0048041)2.58445084
87cell-substrate adherens junction assembly (GO:0007045)2.58445084
88adherens junction assembly (GO:0034333)2.58249751
89NLS-bearing protein import into nucleus (GO:0006607)2.57705691
90* mRNA transport (GO:0051028)2.57474338
91negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.56824341
92paraxial mesoderm development (GO:0048339)2.56604966
93microtubule depolymerization (GO:0007019)2.56162942
94positive regulation of chromosome segregation (GO:0051984)2.56162746
95heterochromatin organization (GO:0070828)2.55817043
96corticosteroid receptor signaling pathway (GO:0031958)2.55668869
97embryonic camera-type eye morphogenesis (GO:0048596)2.54983062
98negative regulation of chromatin modification (GO:1903309)2.54722881
99positive regulation of protein import into nucleus, translocation (GO:0033160)2.54567775
100regulation of glucose import in response to insulin stimulus (GO:2001273)2.54326040
101poly(A)+ mRNA export from nucleus (GO:0016973)2.54295298
102DNA packaging (GO:0006323)2.54243953
103positive regulation of Cdc42 GTPase activity (GO:0043089)2.53590112
104peptidyl-threonine modification (GO:0018210)2.52556042
105peptidyl-threonine phosphorylation (GO:0018107)2.52145389
106ventricular trabecula myocardium morphogenesis (GO:0003222)2.51844729
107maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.49891075
108protein localization to endosome (GO:0036010)2.49247972
109regulation of histone H3-K4 methylation (GO:0051569)2.48698950
110modulation by symbiont of host cellular process (GO:0044068)2.48585891
111regulation of telomere maintenance via telomerase (GO:0032210)2.48441731
112negative regulation of histone modification (GO:0031057)2.47852950
113RNA stabilization (GO:0043489)2.47394750
114mRNA stabilization (GO:0048255)2.47394750
115chromatin assembly (GO:0031497)2.46034965
116histone methylation (GO:0016571)2.46018390
117mitotic sister chromatid segregation (GO:0000070)2.45429535
118positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.45103809
119kinetochore organization (GO:0051383)2.44503225
120desmosome organization (GO:0002934)2.44208820
121DNA topological change (GO:0006265)2.44131606
122positive regulation of DNA-templated transcription, initiation (GO:2000144)2.43522566
123positive regulation of gamma-delta T cell activation (GO:0046645)2.43188376
124pentose-phosphate shunt (GO:0006098)2.40800986
125regulation of DNA-dependent DNA replication (GO:0090329)2.40780700
126regulation of mRNA stability (GO:0043488)2.40563394
127regulation of mitotic spindle checkpoint (GO:1903504)2.40295739
128regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.40295739
129positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.39653679
130regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.39653679
131modulation by virus of host process (GO:0019054)2.39433445
132regulation of mitotic spindle organization (GO:0060236)2.38799377
133germinal center formation (GO:0002467)2.37939381
134gene silencing by RNA (GO:0031047)2.37901631
135embryonic eye morphogenesis (GO:0048048)2.37889756
136regulation of gene silencing (GO:0060968)2.37599669
137glucose 6-phosphate metabolic process (GO:0051156)2.37176943
138regulation of chromatin silencing (GO:0031935)2.37161130
139RNA localization (GO:0006403)2.36644629
140positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.36349964
141mitotic G1 DNA damage checkpoint (GO:0031571)2.36319217
142ncRNA catabolic process (GO:0034661)2.36012213
143* mRNA export from nucleus (GO:0006406)2.35936166
144inner cell mass cell proliferation (GO:0001833)2.35724181
145histone deubiquitination (GO:0016578)2.35579749
146regulation of mammary gland epithelial cell proliferation (GO:0033599)2.35493663
147regulation of DNA-templated transcription, initiation (GO:2000142)2.34900868
148positive regulation of gene expression, epigenetic (GO:0045815)2.34805773
149mitotic chromosome condensation (GO:0007076)2.34490749
150DNA demethylation (GO:0080111)2.34161075
151vesicle coating (GO:0006901)2.33341013
152regulation of double-strand break repair (GO:2000779)2.33285183
153cellular protein complex localization (GO:0034629)2.33170347
154histone H4-K16 acetylation (GO:0043984)2.33073268
155nucleus organization (GO:0006997)2.32683830
156IMP biosynthetic process (GO:0006188)2.32515461
157negative regulation of DNA repair (GO:0045738)2.32469531
158regulation of centrosome duplication (GO:0010824)2.32388617
159regulation of chromatin binding (GO:0035561)2.32369948
160nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.32056249
161peptidyl-lysine dimethylation (GO:0018027)2.31751247
162regulation of gene expression by genetic imprinting (GO:0006349)2.31587721
163regulation of RNA stability (GO:0043487)2.31510309
164stress fiber assembly (GO:0043149)2.31071233
165activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.30910563
166nucleosome disassembly (GO:0006337)2.30601439
167protein-DNA complex disassembly (GO:0032986)2.30601439
168regulation of type I interferon-mediated signaling pathway (GO:0060338)2.29364038
169negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.28534010
170N-terminal protein amino acid acetylation (GO:0006474)2.28233534
171response to laminar fluid shear stress (GO:0034616)2.26055443

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.48310220
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.49390334
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.84480025
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.83604564
5* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.64581457
6TP63_19390658_ChIP-ChIP_HaCaT_Human3.18388083
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.95561593
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.57785737
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.43228843
10* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.39805106
11KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.37764521
12KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.37764521
13KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.37764521
14RBPJ_22232070_ChIP-Seq_NCS_Mouse2.34178002
15* VDR_21846776_ChIP-Seq_THP-1_Human2.25087927
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.20806848
17KDM2B_26808549_Chip-Seq_SUP-B15_Human2.18278679
18* KDM2B_26808549_Chip-Seq_DND41_Human2.13164877
19E2F1_21310950_ChIP-Seq_MCF-7_Human2.02939479
20TP63_17297297_ChIP-ChIP_HaCaT_Human1.96554179
21* RACK7_27058665_Chip-Seq_MCF-7_Human1.96445925
22* ELK3_25401928_ChIP-Seq_HUVEC_Human1.93178958
23SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.92934018
24KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.88116577
25MYC_22102868_ChIP-Seq_BL_Human1.85057390
26SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.83596572
27* IRF8_22096565_ChIP-ChIP_GC-B_Human1.80991946
28NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.80710464
29NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.79055854
30SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.78398814
31LXR_22292898_ChIP-Seq_THP-1_Human1.77861018
32ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.77697863
33SMAD_19615063_ChIP-ChIP_OVARY_Human1.75063920
34TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.73442849
35YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.71299899
36CLOCK_20551151_ChIP-Seq_293T_Human1.70841039
37* MAF_26560356_Chip-Seq_TH1_Human1.70258397
38* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.68855261
39CIITA_25753668_ChIP-Seq_RAJI_Human1.68554530
40KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.67602378
41KDM2B_26808549_Chip-Seq_K562_Human1.66782170
42RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.66058411
43NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.65587921
44SOX2_18555785_ChIP-Seq_MESCs_Mouse1.63840378
45STAT6_21828071_ChIP-Seq_BEAS2B_Human1.62171743
46ZFP281_18757296_ChIP-ChIP_E14_Mouse1.60681795
47ESR2_21235772_ChIP-Seq_MCF-7_Human1.60534150
48TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58761936
49KDM2B_26808549_Chip-Seq_JURKAT_Human1.56814831
50ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.55364787
51TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.55342667
52NCOR1_26117541_ChIP-Seq_K562_Human1.55303247
53BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.55178552
54* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.55131793
55MYB_21317192_ChIP-Seq_ERMYB_Mouse1.54800251
56* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.54386892
57THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.53758619
58EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52215643
59NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.49239287
60ZNF263_19887448_ChIP-Seq_K562_Human1.48726109
61* IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.48569881
62MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.47646728
63VDR_24763502_ChIP-Seq_THP-1_Human1.46886682
64EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.46818442
65WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.46656353
66ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.46149087
67MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.45023035
68IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.44020418
69UTX_26944678_Chip-Seq_JUKART_Human1.41940538
70* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.40852624
71RUNX1_27514584_Chip-Seq_MCF-7_Human1.40044509
72MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.38718018
73HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.38443634
74NANOG_18555785_ChIP-Seq_MESCs_Mouse1.38133644
75PKCTHETA_26484144_Chip-Seq_BREAST_Human1.38009596
76* CHD1_26751641_Chip-Seq_LNCaP_Human1.36842662
77GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.36511229
78E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.35561227
79* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.34985023
80ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.34944442
81DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.34247736
82* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.33728390
83* MAF_26560356_Chip-Seq_TH2_Human1.33475072
84* RUNX1_22412390_ChIP-Seq_EML_Mouse1.32025022
85PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31753027
86FLI1_27457419_Chip-Seq_LIVER_Mouse1.30305086
87DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.30054944
88* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.29994790
89* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.29888766
90* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.29884968
91ESR1_20079471_ChIP-ChIP_T-47D_Human1.29424510
92* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.28566211
93SPI1_23127762_ChIP-Seq_K562_Human1.28297334
94MYCN_18555785_ChIP-Seq_MESCs_Mouse1.26470353
95* CREB1_26743006_Chip-Seq_LNCaP_Human1.23599613
96SOX2_27498859_Chip-Seq_STOMACH_Mouse1.22289586
97ATF3_27146783_Chip-Seq_COLON_Human1.21480189
98* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.20762860
99* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.19458570
100ELK1_19687146_ChIP-ChIP_HELA_Human1.18945084
101SMC4_20622854_ChIP-Seq_HELA_Human1.18449083
102* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.18096124
103* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.17297625
104EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.17193157
105DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.16641463
106ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.16007984
107NOTCH1_21737748_ChIP-Seq_TLL_Human1.15626096
108AR_21909140_ChIP-Seq_LNCAP_Human1.13481146
109TCF3_18692474_ChIP-Seq_MESCs_Mouse1.13245116
110ZFX_18555785_ChIP-Seq_MESCs_Mouse1.10806676
111* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.09176688
112* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.09028859
113* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.08550145
114GATA1_19941827_ChIP-Seq_MEL_Mouse1.08069807
115* MYB_26560356_Chip-Seq_TH1_Human1.07902358
116IRF8_21731497_ChIP-ChIP_J774_Mouse1.06805649
117* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.06739328
118NANOG_21062744_ChIP-ChIP_HESCs_Human1.06545444
119PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.06200568
120HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.05641994
121HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.05023732
122SCL_19346495_ChIP-Seq_HPC-7_Human1.04715527
123* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.04675536
124TFEB_21752829_ChIP-Seq_HELA_Human1.04604192
125MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.03944108
126* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.03238042
127* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.00966698
128TBX3_20139965_ChIP-Seq_ESCs_Mouse1.00535837
129GATA1_19941826_ChIP-Seq_K562_Human0.99142376
130ESR1_15608294_ChIP-ChIP_MCF-7_Human0.98423058
131TBX3_20139965_ChIP-Seq_MESCs_Mouse0.98371344
132TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97857867
133NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.97467891
134* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.96305935
135GATA1_22025678_ChIP-Seq_K562_Human0.96023892
136STAT4_19710469_ChIP-ChIP_TH1__Mouse0.95552172
137PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.95290817
138POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.95274363
139GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.95113777
140TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.94957196
141* TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.94559960
142RUNX_20019798_ChIP-Seq_JUKART_Human0.93268959
143TCF7_22412390_ChIP-Seq_EML_Mouse0.92429510
144* MYB_26560356_Chip-Seq_TH2_Human0.92383721
145NELFA_20434984_ChIP-Seq_ESCs_Mouse0.91541313
146* PADI4_21655091_ChIP-ChIP_MCF-7_Human0.90185034
147* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.89119862
148CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.89117782
149* MYC_19030024_ChIP-ChIP_MESCs_Mouse0.88336647
150* BRD4_25478319_ChIP-Seq_HGPS_Human0.87139914
151POU5F1_16518401_ChIP-PET_MESCs_Mouse0.85214701
152* SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.84335033
153TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.83944985
154VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.83220939
155POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.82262068
156SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.82236395
157PCGF2_27294783_Chip-Seq_ESCs_Mouse0.80937411
158* STAT3_18555785_ChIP-Seq_MESCs_Mouse0.80301261
159KDM5A_27292631_Chip-Seq_BREAST_Human0.77657497
160RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.76364451
161CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.75613190
162POU5F1_16153702_ChIP-ChIP_HESCs_Human0.74572120
163NANOG_16518401_ChIP-PET_MESCs_Mouse0.73542885
164MYC_19079543_ChIP-ChIP_MESCs_Mouse0.72315906
165AHR_22903824_ChIP-Seq_MCF-7_Human0.71775629
166PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.70578974
167TCF4_18268006_ChIP-ChIP_LS174T_Human0.69603682
168ISL1_27105846_Chip-Seq_CPCs_Mouse0.69049634
169* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.68758352

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.95896963
2MP0008877_abnormal_DNA_methylation3.70155975
3MP0005451_abnormal_body_composition3.40712601
4MP0003787_abnormal_imprinting3.17786820
5MP0010234_abnormal_vibrissa_follicle3.16325544
6MP0003705_abnormal_hypodermis_morpholog2.97966062
7MP0000569_abnormal_digit_pigmentation2.96509838
8MP0010094_abnormal_chromosome_stability2.94442927
9MP0003111_abnormal_nucleus_morphology2.66739840
10MP0008058_abnormal_DNA_repair2.65186745
11MP0003121_genomic_imprinting2.54269911
12MP0010352_gastrointestinal_tract_polyps2.35966751
13MP0004233_abnormal_muscle_weight2.31539288
14MP0003077_abnormal_cell_cycle2.25330091
15MP0010307_abnormal_tumor_latency2.22947439
16MP0003890_abnormal_embryonic-extraembry2.19949550
17MP0005367_renal/urinary_system_phenotyp2.19308624
18MP0000516_abnormal_urinary_system2.19308624
19MP0005409_darkened_coat_color2.19056844
20MP0002796_impaired_skin_barrier2.18538527
21MP0002877_abnormal_melanocyte_morpholog2.13612997
22MP0003303_peritoneal_inflammation2.10077930
23MP0003693_abnormal_embryo_hatching2.06409578
24MP0004185_abnormal_adipocyte_glucose1.99270599
25MP0005076_abnormal_cell_differentiation1.98901743
26MP0008007_abnormal_cellular_replicative1.88956114
27MP0003453_abnormal_keratinocyte_physiol1.84150609
28MP0003300_gastrointestinal_ulcer1.83608990
29MP0003123_paternal_imprinting1.77062903
30MP0002009_preneoplasia1.75896131
31MP0003566_abnormal_cell_adhesion1.75216270
32MP0001348_abnormal_lacrimal_gland1.71653668
33MP0004808_abnormal_hematopoietic_stem1.66770878
34MP0004947_skin_inflammation1.64872530
35MP0003091_abnormal_cell_migration1.63505011
36MP0006292_abnormal_olfactory_placode1.63467535
37MP0005666_abnormal_adipose_tissue1.62646301
38MP0005380_embryogenesis_phenotype1.61888648
39MP0001672_abnormal_embryogenesis/_devel1.61888648
40MP0003436_decreased_susceptibility_to1.61808923
41MP0008260_abnormal_autophagy1.60903010
42MP0000350_abnormal_cell_proliferation1.58192560
43MP0003172_abnormal_lysosome_physiology1.58183609
44MP0000678_abnormal_parathyroid_gland1.57599792
45MP0003984_embryonic_growth_retardation1.53718559
46MP0005499_abnormal_olfactory_system1.52562680
47MP0005394_taste/olfaction_phenotype1.52562680
48MP0004197_abnormal_fetal_growth/weight/1.51646261
49MP0002088_abnormal_embryonic_growth/wei1.51473263
50MP0001835_abnormal_antigen_presentation1.49488337
51MP0008789_abnormal_olfactory_epithelium1.43224029
52MP0009703_decreased_birth_body1.41927519
53MP0004957_abnormal_blastocyst_morpholog1.41576311
54MP0003763_abnormal_thymus_physiology1.41254988
55MP0000566_synostosis1.35613506
56MP0002086_abnormal_extraembryonic_tissu1.34550949
57MP0005501_abnormal_skin_physiology1.32312335
58MP0003656_abnormal_erythrocyte_physiolo1.28908568
59MP0001346_abnormal_lacrimal_gland1.26017592
60MP0003941_abnormal_skin_development1.26005486
61MP0005058_abnormal_lysosome_morphology1.23425614
62MP0002084_abnormal_developmental_patter1.23309614
63MP0001730_embryonic_growth_arrest1.22678793
64MP0001216_abnormal_epidermal_layer1.19593749
65MP0002085_abnormal_embryonic_tissue1.18965880
66MP0005375_adipose_tissue_phenotype1.18772749
67MP0003122_maternal_imprinting1.18565437
68MP0002098_abnormal_vibrissa_morphology1.17360342
69MP0002396_abnormal_hematopoietic_system1.16104084
70MP0001697_abnormal_embryo_size1.16058675
71MP0004264_abnormal_extraembryonic_tissu1.15985761
72MP0002006_tumorigenesis1.13963043
73MP0003567_abnormal_fetal_cardiomyocyte1.13225677
74MP0003221_abnormal_cardiomyocyte_apopto1.12524360
75MP0000015_abnormal_ear_pigmentation1.11722917
76MP0001293_anophthalmia1.10719297
77MP0003786_premature_aging1.10514796
78MP0003045_fibrosis1.09790000
79MP0001873_stomach_inflammation1.09289719
80MP0010630_abnormal_cardiac_muscle1.07605197
81MP0000703_abnormal_thymus_morphology1.06330837
82MP0002653_abnormal_ependyma_morphology1.05929364
83MP0004381_abnormal_hair_follicle1.05771646
84MP0002398_abnormal_bone_marrow1.02068889
85MP0000490_abnormal_crypts_of1.01198361
86MP0008961_abnormal_basal_metabolism1.00710265
87MP0005310_abnormal_salivary_gland0.99691692
88MP0003943_abnormal_hepatobiliary_system0.99094183
89MP0000858_altered_metastatic_potential0.97567411
90MP0002166_altered_tumor_susceptibility0.97076124
91MP0008932_abnormal_embryonic_tissue0.96958254
92MP0002925_abnormal_cardiovascular_devel0.96688740
93MP0009672_abnormal_birth_weight0.96265016
94MP0003935_abnormal_craniofacial_develop0.96015844
95MP0005623_abnormal_meninges_morphology0.95330657
96MP0010678_abnormal_skin_adnexa0.95152704
97MP0000627_abnormal_mammary_gland0.94552408
98MP0009931_abnormal_skin_appearance0.93740003
99MP0005171_absent_coat_pigmentation0.93537259
100MP0000432_abnormal_head_morphology0.92425788
101MP0000371_diluted_coat_color0.92378313
102MP0009333_abnormal_splenocyte_physiolog0.91840689
103MP0000377_abnormal_hair_follicle0.91822084
104MP0010155_abnormal_intestine_physiology0.91797918
105MP0005384_cellular_phenotype0.91473308
106MP0002210_abnormal_sex_determination0.91437775
107MP0001849_ear_inflammation0.91312124
108MP0002722_abnormal_immune_system0.91098939
109MP0001915_intracranial_hemorrhage0.89935416
110MP0001853_heart_inflammation0.89898146
111MP0002160_abnormal_reproductive_system0.89031669
112MP0005671_abnormal_response_to0.88474680
113MP0003191_abnormal_cellular_cholesterol0.88274980
114MP0009278_abnormal_bone_marrow0.88105421
115MP0000579_abnormal_nail_morphology0.87784294
116MP0004782_abnormal_surfactant_physiolog0.86973460
117MP0003119_abnormal_digestive_system0.85900321
118MP0000313_abnormal_cell_death0.85858736
119MP0001119_abnormal_female_reproductive0.85244350
120MP0002249_abnormal_larynx_morphology0.84550311
121MP0002080_prenatal_lethality0.84151784
122MP0009115_abnormal_fat_cell0.84124059
123MP0005000_abnormal_immune_tolerance0.83931597
124MP0002060_abnormal_skin_morphology0.83143316
125MP0004858_abnormal_nervous_system0.83009262
126MP0000537_abnormal_urethra_morphology0.82349089
127MP0003315_abnormal_perineum_morphology0.81569148
128MP0003115_abnormal_respiratory_system0.81472578
129MP0002429_abnormal_blood_cell0.80347325
130MP0000716_abnormal_immune_system0.80176406
131MP0000733_abnormal_muscle_development0.79554223
132MP0001851_eye_inflammation0.79463256
133MP0001286_abnormal_eye_development0.78919238
134MP0000428_abnormal_craniofacial_morphol0.77550021
135MP0003755_abnormal_palate_morphology0.77015063
136MP0005645_abnormal_hypothalamus_physiol0.76033500
137MP0003448_altered_tumor_morphology0.74673208
138MP0001800_abnormal_humoral_immune0.74311855
139MP0002938_white_spotting0.73329180
140MP0004510_myositis0.72809710
141MP0002127_abnormal_cardiovascular_syste0.72347044
142MP0003861_abnormal_nervous_system0.71701058
143MP0003936_abnormal_reproductive_system0.71081684
144MP0001186_pigmentation_phenotype0.70364691
145MP0001790_abnormal_immune_system0.70054009
146MP0005387_immune_system_phenotype0.70054009
147MP0005397_hematopoietic_system_phenotyp0.69515106
148MP0001545_abnormal_hematopoietic_system0.69515106
149MP0002277_abnormal_respiratory_mucosa0.68096939
150MP0002116_abnormal_craniofacial_bone0.67274524
151MP0001145_abnormal_male_reproductive0.67256871
152MP0002019_abnormal_tumor_incidence0.67127659
153MP0001929_abnormal_gametogenesis0.66198385
154MP0005389_reproductive_system_phenotype0.66010790
155MP0005248_abnormal_Harderian_gland0.65775119
156MP0003937_abnormal_limbs/digits/tail_de0.64961653
157MP0005621_abnormal_cell_physiology0.64455975

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)3.71562887
2Chromosomal breakage induced by crosslinking agents (HP:0003221)3.34135182
3Ectopic kidney (HP:0000086)3.32279580
4Chromsome breakage (HP:0040012)3.28419020
5Papillary thyroid carcinoma (HP:0002895)3.20895067
6Hyperacusis (HP:0010780)3.18670508
7Volvulus (HP:0002580)2.96095454
8Abnormality of the nasal septum (HP:0000419)2.93366159
9Obstructive sleep apnea (HP:0002870)2.92622258
10Spinal cord lesions (HP:0100561)2.87506063
11Syringomyelia (HP:0003396)2.87506063
12Deep philtrum (HP:0002002)2.83944980
13Ankyloglossia (HP:0010296)2.82388124
14Neoplasm of the adrenal cortex (HP:0100641)2.79998201
15Medulloblastoma (HP:0002885)2.68034931
16Glioma (HP:0009733)2.67951693
17Broad face (HP:0000283)2.62335932
18Abnormality of the astrocytes (HP:0100707)2.62287223
19Astrocytoma (HP:0009592)2.62287223
20Absent frontal sinuses (HP:0002688)2.61742168
21Ependymoma (HP:0002888)2.57653425
22Intestinal fistula (HP:0100819)2.53394771
23Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.50531958
24Lip pit (HP:0100267)2.46840679
25Bowel incontinence (HP:0002607)2.44893689
26Agnosia (HP:0010524)2.43930604
27Anal stenosis (HP:0002025)2.41244630
28Dysmetric saccades (HP:0000641)2.39808437
29Rhabdomyosarcoma (HP:0002859)2.37363192
30Asymmetry of the thorax (HP:0001555)2.37204543
31Heterotopia (HP:0002282)2.33405121
32Urethral obstruction (HP:0000796)2.32566127
33Abnormality of the salivary glands (HP:0010286)2.30673825
34Abnormality of chromosome stability (HP:0003220)2.28808159
35Trigonocephaly (HP:0000243)2.28779961
36Insidious onset (HP:0003587)2.26978606
37Termporal pattern (HP:0011008)2.26978606
38Impulsivity (HP:0100710)2.26096605
39Abnormal large intestine physiology (HP:0012700)2.25570564
40Abnormality of the distal phalanx of the thumb (HP:0009617)2.25096197
41Slow saccadic eye movements (HP:0000514)2.24102139
42Abnormality of oral frenula (HP:0000190)2.21462923
43Long eyelashes (HP:0000527)2.18957636
44Sparse lateral eyebrow (HP:0005338)2.18401239
45Supernumerary ribs (HP:0005815)2.16343769
46Abnormality of chromosome segregation (HP:0002916)2.15460297
47Septate vagina (HP:0001153)2.15234817
48Metaphyseal cupping (HP:0003021)2.14785184
49Thyroid carcinoma (HP:0002890)2.13550995
50Decreased motor nerve conduction velocity (HP:0003431)2.07591513
51Distal upper limb amyotrophy (HP:0007149)2.06471067
52Upper limb amyotrophy (HP:0009129)2.06471067
53Insomnia (HP:0100785)2.06421950
54Overlapping toe (HP:0001845)2.03997283
55Meckel diverticulum (HP:0002245)2.03916894
56Flat acetabular roof (HP:0003180)2.03746136
57Cholecystitis (HP:0001082)2.02048970
58Abnormal gallbladder physiology (HP:0012438)2.02048970
59Supernumerary bones of the axial skeleton (HP:0009144)2.01155625
60Intestinal atresia (HP:0011100)1.99655472
61Aplasia/Hypoplasia of the uvula (HP:0010293)1.98578238
62Segmental peripheral demyelination/remyelination (HP:0003481)1.98448573
63Distal lower limb amyotrophy (HP:0008944)1.97144563
64Increased IgE level (HP:0003212)1.96192216
65Germ cell neoplasia (HP:0100728)1.96105157
66Short 4th metacarpal (HP:0010044)1.95641380
67Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.95641380
68Degeneration of anterior horn cells (HP:0002398)1.95614685
69Abnormality of the anterior horn cell (HP:0006802)1.95614685
70Nephroblastoma (Wilms tumor) (HP:0002667)1.94776378
71Neoplasm of the oral cavity (HP:0100649)1.93993130
72Abnormality of the ileum (HP:0001549)1.93261061
73Truncal obesity (HP:0001956)1.92239968
74Deviation of the thumb (HP:0009603)1.91815723
75Centrally nucleated skeletal muscle fibers (HP:0003687)1.91360911
76Deep palmar crease (HP:0006191)1.91360852
77Abnormality of the labia minora (HP:0012880)1.91172281
78Amaurosis fugax (HP:0100576)1.90878484
79Abnormality of the intervertebral disk (HP:0005108)1.87772113
80Long clavicles (HP:0000890)1.87371274
81Hand muscle atrophy (HP:0009130)1.86015426
82Tongue fasciculations (HP:0001308)1.85469905
83Optic nerve coloboma (HP:0000588)1.85447210
84Neoplasm of striated muscle (HP:0009728)1.85178038
85Patellar aplasia (HP:0006443)1.84952668
86Subacute progressive viral hepatitis (HP:0006572)1.84408308
87Patellar dislocation (HP:0002999)1.84302658
88Rectal fistula (HP:0100590)1.84275073
89Rectovaginal fistula (HP:0000143)1.84275073
90Aplasia/Hypoplasia of the sternum (HP:0006714)1.83059970
91Abnormality of the metopic suture (HP:0005556)1.83008980
92Advanced eruption of teeth (HP:0006288)1.81882260
93Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.81727887
94Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.80464792
95Hyperparathyroidism (HP:0000843)1.80176466
96Clubbing of toes (HP:0100760)1.78922920
97Increased nuchal translucency (HP:0010880)1.78512596
98Cystic hygroma (HP:0000476)1.78340702
99Hepatoblastoma (HP:0002884)1.78321938
100Gastrointestinal atresia (HP:0002589)1.77751145
101Progressive hearing impairment (HP:0001730)1.77185233
102Uterine leiomyosarcoma (HP:0002891)1.77073670
103Leiomyosarcoma (HP:0100243)1.77073670
104Abnormal number of incisors (HP:0011064)1.76849723
105Embryonal renal neoplasm (HP:0011794)1.76798207
106Prominent metopic ridge (HP:0005487)1.76228113
107Macroorchidism (HP:0000053)1.76208781
108Increased number of teeth (HP:0011069)1.72918842
109Spinal muscular atrophy (HP:0007269)1.71230010
110Right ventricular cardiomyopathy (HP:0011663)1.70833196
111Abnormality of the incisor (HP:0000676)1.70736928
112Sandal gap (HP:0001852)1.70661170
113Fatigue (HP:0012378)1.70524569
114Overriding aorta (HP:0002623)1.70012390
115Shawl scrotum (HP:0000049)1.69921652
116Low anterior hairline (HP:0000294)1.69053733
117Cutis marmorata (HP:0000965)1.68954462
118Curly hair (HP:0002212)1.68745258
119Birth length less than 3rd percentile (HP:0003561)1.68584712
120Pseudobulbar signs (HP:0002200)1.68326909
121Pancreatic fibrosis (HP:0100732)1.67718922
122Long palpebral fissure (HP:0000637)1.66688260
123Hyperkalemia (HP:0002153)1.66625674
124Micronodular cirrhosis (HP:0001413)1.65763305
125Prominent nose (HP:0000448)1.64889655
126Short middle phalanx of the 5th finger (HP:0004220)1.64870398
127Muscle fibrillation (HP:0010546)1.64514185
128Cutaneous melanoma (HP:0012056)1.64488093
129Unilateral renal agenesis (HP:0000122)1.63894110
130Abnormality of the columella (HP:0009929)1.63310333
131Proximal placement of thumb (HP:0009623)1.62974985
132Aplasia/Hypoplasia of the patella (HP:0006498)1.62094296
133Viral hepatitis (HP:0006562)1.61953032
134Abnormality of the carotid arteries (HP:0005344)1.61900565
135Seborrheic dermatitis (HP:0001051)1.61772836
136Eczematoid dermatitis (HP:0000976)1.61592445
137Benign neoplasm of the central nervous system (HP:0100835)1.61585013
138Hammertoe (HP:0001765)1.61574023
139Myelodysplasia (HP:0002863)1.60897471
140Duodenal stenosis (HP:0100867)1.60404672
141Small intestinal stenosis (HP:0012848)1.60404672
142Facial cleft (HP:0002006)1.59749895
143Disproportionate tall stature (HP:0001519)1.59395898
144Hypoplasia of the maxilla (HP:0000327)1.58119506
145Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.58021296
146Acute myeloid leukemia (HP:0004808)1.57953773
147Preaxial hand polydactyly (HP:0001177)1.57588966
148Renovascular hypertension (HP:0100817)1.57538280
149Prostate neoplasm (HP:0100787)1.57255617
150Abnormal lung lobation (HP:0002101)1.57225139
151Truncus arteriosus (HP:0001660)1.57155913
152Renal cell carcinoma (HP:0005584)1.56948962
153Abnormality of the gastric mucosa (HP:0004295)1.56417269
154Median cleft lip (HP:0000161)1.56275085
155Relative macrocephaly (HP:0004482)1.56250786
156Skull defect (HP:0001362)1.56118480
157Abnormality of the frontal sinuses (HP:0002687)1.56107706
158Recurrent viral infections (HP:0004429)1.55807758
159Arnold-Chiari malformation (HP:0002308)1.55498545
160Pointed chin (HP:0000307)1.55316721
161Narrow palate (HP:0000189)1.55224862
162Transitional cell carcinoma of the bladder (HP:0006740)1.54678476
163Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.53233897
164Cellulitis (HP:0100658)1.52859638
165Resting tremor (HP:0002322)1.52684021
166Abnormality of the preputium (HP:0100587)1.52626619
167Lower limb amyotrophy (HP:0007210)1.52510774
168Neoplasm of the tracheobronchial system (HP:0100552)1.52494259
169Obsessive-compulsive behavior (HP:0000722)1.52286268
170Cafe-au-lait spot (HP:0000957)1.52192425
171Gastrointestinal carcinoma (HP:0002672)1.52086590
172Malignant gastrointestinal tract tumors (HP:0006749)1.52086590
173Precocious puberty (HP:0000826)1.51109709
174Limited elbow extension (HP:0001377)1.50984358
175Reticulocytosis (HP:0001923)1.49903452
176Neuronal loss in central nervous system (HP:0002529)1.48900323
177Progressive sensorineural hearing impairment (HP:0000408)1.48713275
178Aplasia/Hypoplasia of the thymus (HP:0010515)1.47366993

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.35186985
2TRIB33.54160402
3ZAK3.33601095
4SMG13.32642657
5AKT32.96601123
6ICK2.73657483
7MAP3K142.62573146
8BRD42.59103582
9SIK32.50588217
10LATS12.41448738
11SRPK12.26435576
12RIPK42.16563901
13ERN12.14740337
14PRPF4B2.07308337
15MKNK22.05255978
16SIK12.03671756
17SGK22.00381696
18CDC71.97848574
19FGFR41.90687139
20KSR21.90096987
21ERBB31.87283046
22EEF2K1.85744223
23PLK31.73211801
24IRAK31.69270311
25FGFR31.66721897
26PLK41.65281376
27SGK31.63930372
28JAK31.61924911
29TXK1.54818001
30STK38L1.53371735
31TSSK61.53288952
32MKNK11.48472918
33CHUK1.48345063
34MAP3K91.43306584
35NUAK11.40968319
36TRPM71.40231013
37ATR1.39926471
38PLK21.36406568
39PIM11.34039667
40EPHA21.31315996
41PKN21.29839815
42STK31.28448042
43NEK11.24351320
44MAP3K131.24022410
45EIF2AK11.23287855
46TTK1.17054525
47ALK1.16809947
48SIK21.15125687
49CHEK11.13771484
50NEK61.12718432
51ATM1.11634480
52LATS21.11486956
53STK241.10926907
54RPS6KB11.10395468
55PDGFRA1.08437334
56MARK21.07188895
57BMPR21.06257894
58EPHB11.06159442
59YES11.04391668
60NEK21.03076463
61CHEK21.02726365
62SCYL21.02603283
63RIPK11.00723568
64PASK0.99605435
65FRK0.95942471
66PRKD30.92603337
67MAP3K20.90898219
68CLK10.90300059
69MELK0.90230371
70TAOK10.89468882
71STK40.89066164
72MST1R0.88352753
73RPS6KB20.86392035
74PLK10.85878849
75CDK20.85265741
76KSR10.84263039
77CDK40.83558567
78HIPK20.83398577
79TYRO30.82223293
80MAP3K10.80806631
81STK380.80339177
82MAPK130.79198253
83PRKCH0.78477458
84SGK2230.77377705
85SGK4940.77377705
86CDK60.76370463
87RPS6KA20.73576984
88CDK70.73452846
89MAP3K100.72968196
90RET0.71854343
91MTOR0.71512289
92PAK40.71263416
93BRSK20.70598158
94MAPK140.70230063
95CAMK40.69849713
96MAP3K80.69553060
97ZAP700.69530967
98SGK10.68539737
99CDK90.68102140
100IRAK20.66916728
101TAOK20.66406316
102LRRK20.65278319
103MAPK100.65004065
104JAK10.64831507
105MARK30.63890773
106PTK60.63081046
107CDK10.62865044
108MAP2K30.62365315
109RPS6KA60.60714028
110RPS6KL10.59550455
111RPS6KC10.59550455
112PDPK10.59217802
113GSK3B0.57820107
114MAPK110.56610909
115AKT10.56421284
116NEK90.55998044
117EIF2AK20.55609679
118TYK20.55407999
119PDK10.54323355
120DYRK1A0.53949200
121IKBKB0.53437654
122BMX0.53422336
123PRKD20.53266655
124CDC42BPA0.52791807
125TESK10.52768119
126AURKB0.52104089
127PTK20.51365092
128IKBKE0.50152913
129STK100.48913615
130PRKDC0.47323567
131CSNK1D0.47256533
132DMPK0.47251322
133MAP4K10.46833017
134JAK20.46745088
135CAMK1G0.46360467
136CAMK1D0.46199297
137RAF10.45800802
138CDK30.45768213
139PDGFRB0.43680439
140MET0.43237449
141MAPK80.42967172
142PNCK0.42854622
143FGR0.41117394
144IRAK40.40936043
145WNK10.39052426
146PRKAA10.38875385
147BCR0.37028040
148MAPKAPK20.36319989
149MAP3K30.36283965
150CSK0.36278103
151MAPK10.36044629
152BRSK10.35068016
153TBK10.34818500
154EIF2AK30.33696975
155MAP3K70.30695378
156MAP2K20.30691983

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.13120714
2Mismatch repair_Homo sapiens_hsa034301.93125078
3RNA transport_Homo sapiens_hsa030131.84674028
4Cell cycle_Homo sapiens_hsa041101.83586637
5* mRNA surveillance pathway_Homo sapiens_hsa030151.83304175
6Renal cell carcinoma_Homo sapiens_hsa052111.78211359
7Fanconi anemia pathway_Homo sapiens_hsa034601.71108347
8NF-kappa B signaling pathway_Homo sapiens_hsa040641.54857646
9VEGF signaling pathway_Homo sapiens_hsa043701.54299214
10Central carbon metabolism in cancer_Homo sapiens_hsa052301.52823153
11RNA degradation_Homo sapiens_hsa030181.51808047
12Herpes simplex infection_Homo sapiens_hsa051681.49713923
13Adherens junction_Homo sapiens_hsa045201.46353964
14Graft-versus-host disease_Homo sapiens_hsa053321.43832283
15Allograft rejection_Homo sapiens_hsa053301.41847779
16Non-homologous end-joining_Homo sapiens_hsa034501.41607968
17Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.39283316
18Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.38499821
19Spliceosome_Homo sapiens_hsa030401.38018213
20Bladder cancer_Homo sapiens_hsa052191.36384510
21Base excision repair_Homo sapiens_hsa034101.36151391
22Measles_Homo sapiens_hsa051621.35461579
23Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.35291590
24Basal transcription factors_Homo sapiens_hsa030221.33353497
25Influenza A_Homo sapiens_hsa051641.32357353
26Hepatitis C_Homo sapiens_hsa051601.30188715
27DNA replication_Homo sapiens_hsa030301.29422246
28Notch signaling pathway_Homo sapiens_hsa043301.28592013
29Type I diabetes mellitus_Homo sapiens_hsa049401.28107684
30MicroRNAs in cancer_Homo sapiens_hsa052061.27558522
31One carbon pool by folate_Homo sapiens_hsa006701.25983234
32p53 signaling pathway_Homo sapiens_hsa041151.22157656
33Primary immunodeficiency_Homo sapiens_hsa053401.19499022
34Thyroid hormone signaling pathway_Homo sapiens_hsa049191.18720685
35Homologous recombination_Homo sapiens_hsa034401.18645775
36Transcriptional misregulation in cancer_Homo sapiens_hsa052021.17509182
37AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.17435798
38Antigen processing and presentation_Homo sapiens_hsa046121.16769542
39Insulin signaling pathway_Homo sapiens_hsa049101.16748750
40Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.16463535
41Endometrial cancer_Homo sapiens_hsa052131.15827071
42Viral myocarditis_Homo sapiens_hsa054161.15655815
43HTLV-I infection_Homo sapiens_hsa051661.15544786
44Choline metabolism in cancer_Homo sapiens_hsa052311.14219757
45Intestinal immune network for IgA production_Homo sapiens_hsa046721.12691744
46Estrogen signaling pathway_Homo sapiens_hsa049151.08308324
47Viral carcinogenesis_Homo sapiens_hsa052031.06810444
48Epstein-Barr virus infection_Homo sapiens_hsa051691.04076514
49Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.03186324
50Lysine degradation_Homo sapiens_hsa003101.01237994
51Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.01075971
52Long-term potentiation_Homo sapiens_hsa047200.98692276
53Prostate cancer_Homo sapiens_hsa052150.98180659
54mTOR signaling pathway_Homo sapiens_hsa041500.97560438
55TNF signaling pathway_Homo sapiens_hsa046680.97222348
56Nucleotide excision repair_Homo sapiens_hsa034200.96287000
57Leishmaniasis_Homo sapiens_hsa051400.96084590
58Legionellosis_Homo sapiens_hsa051340.95557588
59Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.95240922
60Colorectal cancer_Homo sapiens_hsa052100.93932543
61T cell receptor signaling pathway_Homo sapiens_hsa046600.93258793
62Autoimmune thyroid disease_Homo sapiens_hsa053200.93090766
63Hippo signaling pathway_Homo sapiens_hsa043900.92962795
64Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.92823941
65Hepatitis B_Homo sapiens_hsa051610.92561283
66Chronic myeloid leukemia_Homo sapiens_hsa052200.92272789
67FoxO signaling pathway_Homo sapiens_hsa040680.89638407
68RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.88512758
69Sphingolipid signaling pathway_Homo sapiens_hsa040710.88215872
70Small cell lung cancer_Homo sapiens_hsa052220.88086431
71Shigellosis_Homo sapiens_hsa051310.87918112
72Toll-like receptor signaling pathway_Homo sapiens_hsa046200.87447470
73Oocyte meiosis_Homo sapiens_hsa041140.86609434
74NOD-like receptor signaling pathway_Homo sapiens_hsa046210.85494649
75Prion diseases_Homo sapiens_hsa050200.85324348
76Neurotrophin signaling pathway_Homo sapiens_hsa047220.84971339
77Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.84925907
78Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.82772926
79Pentose phosphate pathway_Homo sapiens_hsa000300.82065308
80Apoptosis_Homo sapiens_hsa042100.81411741
81Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.81324940
82Toxoplasmosis_Homo sapiens_hsa051450.80805567
83Basal cell carcinoma_Homo sapiens_hsa052170.80467564
84Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.80407281
85AMPK signaling pathway_Homo sapiens_hsa041520.79643496
86GnRH signaling pathway_Homo sapiens_hsa049120.79486144
87Insulin resistance_Homo sapiens_hsa049310.79416909
88Chemokine signaling pathway_Homo sapiens_hsa040620.78823073
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.78582669
90Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.77378461
91Phospholipase D signaling pathway_Homo sapiens_hsa040720.77336094
92Endocytosis_Homo sapiens_hsa041440.75855869
93Other glycan degradation_Homo sapiens_hsa005110.75764621
94Dorso-ventral axis formation_Homo sapiens_hsa043200.75535162
95Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.74735391
96Prolactin signaling pathway_Homo sapiens_hsa049170.74266109
97TGF-beta signaling pathway_Homo sapiens_hsa043500.73542427
98Wnt signaling pathway_Homo sapiens_hsa043100.73013006
99Asthma_Homo sapiens_hsa053100.72364493
100Jak-STAT signaling pathway_Homo sapiens_hsa046300.72325528
101MAPK signaling pathway_Homo sapiens_hsa040100.69715944
102Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.69238337
103B cell receptor signaling pathway_Homo sapiens_hsa046620.68682283
104Pathways in cancer_Homo sapiens_hsa052000.68178539
105Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.68091064
106HIF-1 signaling pathway_Homo sapiens_hsa040660.68062472
107Proteoglycans in cancer_Homo sapiens_hsa052050.65876740
108Amoebiasis_Homo sapiens_hsa051460.65594139
109ErbB signaling pathway_Homo sapiens_hsa040120.65248852
110Type II diabetes mellitus_Homo sapiens_hsa049300.64601000
111RNA polymerase_Homo sapiens_hsa030200.64432998
112Pancreatic cancer_Homo sapiens_hsa052120.64010027
113Olfactory transduction_Homo sapiens_hsa047400.63921615
114Thyroid cancer_Homo sapiens_hsa052160.63531740
115Osteoclast differentiation_Homo sapiens_hsa043800.63344719
116Hematopoietic cell lineage_Homo sapiens_hsa046400.62880270
117Melanoma_Homo sapiens_hsa052180.62441479
118Non-small cell lung cancer_Homo sapiens_hsa052230.62256919
119Phototransduction_Homo sapiens_hsa047440.61722781
120Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61563198
121Acute myeloid leukemia_Homo sapiens_hsa052210.61238594
122Glioma_Homo sapiens_hsa052140.60350406
123Inositol phosphate metabolism_Homo sapiens_hsa005620.60167579
124Leukocyte transendothelial migration_Homo sapiens_hsa046700.59156872
125Adipocytokine signaling pathway_Homo sapiens_hsa049200.58842675
126Regulation of actin cytoskeleton_Homo sapiens_hsa048100.58424276
127Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.58036827
128Hedgehog signaling pathway_Homo sapiens_hsa043400.55440913
129Salmonella infection_Homo sapiens_hsa051320.55003203
130Tuberculosis_Homo sapiens_hsa051520.54822946
131Focal adhesion_Homo sapiens_hsa045100.54305184
132Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53778557
133Biosynthesis of amino acids_Homo sapiens_hsa012300.53453199
134Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52143018
135Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49695570
136Fatty acid biosynthesis_Homo sapiens_hsa000610.48276749
137Fructose and mannose metabolism_Homo sapiens_hsa000510.46644234

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