Rank | Gene Set | Z-score |
---|---|---|
1 | Golgi transport vesicle coating (GO:0048200) | 5.13811964 |
2 | COPI coating of Golgi vesicle (GO:0048205) | 5.13811964 |
3 | protein localization to kinetochore (GO:0034501) | 4.89243771 |
4 | nuclear pore organization (GO:0006999) | 4.85801121 |
5 | nuclear pore complex assembly (GO:0051292) | 4.81539212 |
6 | DNA unwinding involved in DNA replication (GO:0006268) | 4.80719618 |
7 | mitotic nuclear envelope disassembly (GO:0007077) | 4.64688508 |
8 | spliceosomal tri-snRNP complex assembly (GO:0000244) | 4.53349221 |
9 | folic acid-containing compound biosynthetic process (GO:0009396) | 4.46215386 |
10 | membrane disassembly (GO:0030397) | 4.35629946 |
11 | nuclear envelope disassembly (GO:0051081) | 4.35629946 |
12 | protein localization to chromosome, centromeric region (GO:0071459) | 4.16696129 |
13 | mitotic metaphase plate congression (GO:0007080) | 4.12340713 |
14 | DNA replication checkpoint (GO:0000076) | 4.08018307 |
15 | formation of translation preinitiation complex (GO:0001731) | 3.98162785 |
16 | pre-miRNA processing (GO:0031054) | 3.95535810 |
17 | DNA replication initiation (GO:0006270) | 3.94086874 |
18 | nucleobase biosynthetic process (GO:0046112) | 3.84485399 |
19 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.84015478 |
20 | mitotic chromosome condensation (GO:0007076) | 3.75817877 |
21 | regulation of attachment of spindle microtubules to kinetochore (GO:0051988) | 3.71019254 |
22 | regulation of spindle organization (GO:0090224) | 3.70220972 |
23 | DNA replication-dependent nucleosome organization (GO:0034723) | 3.69954450 |
24 | DNA replication-dependent nucleosome assembly (GO:0006335) | 3.69954450 |
25 | ribosome assembly (GO:0042255) | 3.66251607 |
26 | DNA strand elongation (GO:0022616) | 3.65351799 |
27 | positive regulation of chromosome segregation (GO:0051984) | 3.63339092 |
28 | pore complex assembly (GO:0046931) | 3.62754533 |
29 | negative regulation of histone methylation (GO:0031061) | 3.61754191 |
30 | proline biosynthetic process (GO:0006561) | 3.60613333 |
31 | establishment of integrated proviral latency (GO:0075713) | 3.56509670 |
32 | heterochromatin organization (GO:0070828) | 3.55807091 |
33 | IMP biosynthetic process (GO:0006188) | 3.53206243 |
34 | purine nucleobase biosynthetic process (GO:0009113) | 3.51927366 |
35 | metaphase plate congression (GO:0051310) | 3.49468324 |
36 | nuclear envelope organization (GO:0006998) | 3.49417522 |
37 | regulation of mitotic spindle organization (GO:0060236) | 3.45017282 |
38 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 3.44459058 |
39 | regulation of mammary gland epithelial cell proliferation (GO:0033599) | 3.37558590 |
40 | protein complex localization (GO:0031503) | 3.36974607 |
41 | mitotic sister chromatid segregation (GO:0000070) | 3.31982845 |
42 | histone H2A monoubiquitination (GO:0035518) | 3.31391837 |
43 | COPII vesicle coating (GO:0048208) | 3.30813147 |
44 | regulation of RNA export from nucleus (GO:0046831) | 3.30346843 |
45 | protein localization to chromosome (GO:0034502) | 3.26305075 |
46 | peptidyl-arginine omega-N-methylation (GO:0035247) | 3.24004907 |
47 | DNA duplex unwinding (GO:0032508) | 3.23514711 |
48 | IMP metabolic process (GO:0046040) | 3.22871358 |
49 | cellular protein complex localization (GO:0034629) | 3.22366067 |
50 | regulation of histone H3-K9 methylation (GO:0051570) | 3.21769914 |
51 | DNA geometric change (GO:0032392) | 3.21006204 |
52 | retrograde vesicle-mediated transport, Golgi to ER (GO:0006890) | 3.20881552 |
53 | regulation of sister chromatid cohesion (GO:0007063) | 3.18240172 |
54 | sister chromatid segregation (GO:0000819) | 3.17465535 |
55 | attachment of spindle microtubules to kinetochore (GO:0008608) | 3.13254439 |
56 | mitochondrial DNA metabolic process (GO:0032042) | 3.11885605 |
57 | regulation of translational termination (GO:0006449) | 3.10133605 |
58 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 3.09271430 |
59 | establishment of chromosome localization (GO:0051303) | 3.07405235 |
60 | regulation of chromosome segregation (GO:0051983) | 3.05050253 |
61 | regulation of metaphase/anaphase transition of cell cycle (GO:1902099) | 3.04194359 |
62 | maturation of SSU-rRNA (GO:0030490) | 3.03019608 |
63 | negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100) | 3.01903709 |
64 | negative regulation of chromosome segregation (GO:0051985) | 2.99731244 |
65 | folic acid metabolic process (GO:0046655) | 2.99233005 |
66 | protein K6-linked ubiquitination (GO:0085020) | 2.97463986 |
67 | ribosome biogenesis (GO:0042254) | 2.96846166 |
68 | spindle checkpoint (GO:0031577) | 2.96823926 |
69 | telomere maintenance via semi-conservative replication (GO:0032201) | 2.96641563 |
70 | mitotic sister chromatid cohesion (GO:0007064) | 2.96319648 |
71 | regulation of mitotic metaphase/anaphase transition (GO:0030071) | 2.96312542 |
72 | mitotic spindle checkpoint (GO:0071174) | 2.95481738 |
73 | double-strand break repair via nonhomologous end joining (GO:0006303) | 2.95328984 |
74 | non-recombinational repair (GO:0000726) | 2.95328984 |
75 | establishment of viral latency (GO:0019043) | 2.94398008 |
76 | mitotic spindle assembly checkpoint (GO:0007094) | 2.93270304 |
77 | chromatin assembly (GO:0031497) | 2.93268625 |
78 | peptidyl-arginine methylation (GO:0018216) | 2.91733446 |
79 | peptidyl-arginine N-methylation (GO:0035246) | 2.91733446 |
80 | negative regulation of mitotic sister chromatid separation (GO:2000816) | 2.91564048 |
81 | negative regulation of mitotic sister chromatid segregation (GO:0033048) | 2.91564048 |
82 | negative regulation of mitotic metaphase/anaphase transition (GO:0045841) | 2.91564048 |
83 | negative regulation of sister chromatid segregation (GO:0033046) | 2.91564048 |
84 | spindle assembly checkpoint (GO:0071173) | 2.90133611 |
85 | chromatin assembly or disassembly (GO:0006333) | 2.88263291 |
86 | protein export from nucleus (GO:0006611) | 2.88093343 |
87 | positive regulation of mitotic metaphase/anaphase transition (GO:0045842) | 2.86066927 |
88 | positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101) | 2.86066927 |
89 | positive regulation of mitotic sister chromatid separation (GO:1901970) | 2.86066927 |
90 | mitochondrial fusion (GO:0008053) | 2.82867520 |
91 | regulation of translational fidelity (GO:0006450) | 2.81111869 |
92 | snRNA metabolic process (GO:0016073) | 2.80681442 |
93 | maturation of 5.8S rRNA (GO:0000460) | 2.80214274 |
94 | translesion synthesis (GO:0019985) | 2.79992130 |
95 | regulation of NFAT protein import into nucleus (GO:0051532) | 2.78950174 |
96 | mitotic recombination (GO:0006312) | 2.77933983 |
97 | telomere maintenance via recombination (GO:0000722) | 2.77826494 |
98 | histone arginine methylation (GO:0034969) | 2.76873265 |
99 | regulation of centriole replication (GO:0046599) | 2.74660254 |
100 | tRNA aminoacylation for protein translation (GO:0006418) | 2.72560309 |
101 | gene silencing by RNA (GO:0031047) | 2.71260187 |
102 | negative regulation of mRNA splicing, via spliceosome (GO:0048025) | 2.70454234 |
103 | vesicle coating (GO:0006901) | 2.69497683 |
104 | kinetochore organization (GO:0051383) | 2.69479228 |
105 | DNA synthesis involved in DNA repair (GO:0000731) | 2.67523989 |
106 | inner cell mass cell proliferation (GO:0001833) | 2.66557479 |
107 | regulation of posttranscriptional gene silencing (GO:0060147) | 2.66017101 |
108 | regulation of gene silencing by miRNA (GO:0060964) | 2.66017101 |
109 | regulation of gene silencing by RNA (GO:0060966) | 2.66017101 |
110 | DNA replication-independent nucleosome assembly (GO:0006336) | 2.65573985 |
111 | DNA replication-independent nucleosome organization (GO:0034724) | 2.65573985 |
112 | regulation of DNA damage checkpoint (GO:2000001) | 2.65214617 |
113 | regulation of sister chromatid segregation (GO:0033045) | 2.64989898 |
114 | regulation of mitotic sister chromatid separation (GO:0010965) | 2.64989898 |
115 | regulation of mitotic sister chromatid segregation (GO:0033047) | 2.64989898 |
116 | 3-UTR-mediated mRNA stabilization (GO:0070935) | 2.63588488 |
117 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 2.63018931 |
118 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 2.63018931 |
119 | chromosome segregation (GO:0007059) | 2.62807322 |
120 | amino acid activation (GO:0043038) | 2.62133056 |
121 | tRNA aminoacylation (GO:0043039) | 2.62133056 |
122 | nucleobase-containing small molecule interconversion (GO:0015949) | 2.61399880 |
123 | positive regulation of SMAD protein import into nucleus (GO:0060391) | 2.61283134 |
124 | mRNA transport (GO:0051028) | 2.60802445 |
125 | DNA conformation change (GO:0071103) | 2.59866745 |
126 | regulation of nucleobase-containing compound transport (GO:0032239) | 2.59456701 |
127 | negative regulation of mRNA metabolic process (GO:1903312) | 2.57159188 |
128 | de novo protein folding (GO:0006458) | 2.54824830 |
129 | viral mRNA export from host cell nucleus (GO:0046784) | 2.54587648 |
130 | dosage compensation (GO:0007549) | 2.53986596 |
131 | positive regulation of keratinocyte differentiation (GO:0045618) | 2.53506836 |
132 | embryonic process involved in female pregnancy (GO:0060136) | 2.52841245 |
133 | de novo posttranslational protein folding (GO:0051084) | 2.52394169 |
134 | protein-DNA complex disassembly (GO:0032986) | 2.49420582 |
135 | nucleosome disassembly (GO:0006337) | 2.49420582 |
136 | RNA stabilization (GO:0043489) | 2.48711080 |
137 | mRNA stabilization (GO:0048255) | 2.48711080 |
138 | regulation of chromatin binding (GO:0035561) | 2.48468378 |
139 | mRNA export from nucleus (GO:0006406) | 2.48157091 |
140 | maintenance of protein localization in endoplasmic reticulum (GO:0035437) | 2.47169794 |
141 | negative regulation of mRNA processing (GO:0050686) | 2.47162459 |
142 | histone H2B ubiquitination (GO:0033523) | 2.44633016 |
143 | positive regulation of cell cycle checkpoint (GO:1901978) | 2.44333242 |
144 | RNA export from nucleus (GO:0006405) | 2.43616271 |
145 | snRNA processing (GO:0016180) | 2.41924659 |
146 | peptidyl-lysine dimethylation (GO:0018027) | 2.41515704 |
147 | regulation of translational initiation (GO:0006446) | 2.40483787 |
148 | rRNA transcription (GO:0009303) | 2.40162739 |
149 | adherens junction assembly (GO:0034333) | 2.40065036 |
150 | histone H3-K9 demethylation (GO:0033169) | 2.39137177 |
151 | chromosome condensation (GO:0030261) | 2.38806976 |
Rank | Gene Set | Z-score |
---|---|---|
1 | E2F7_22180533_ChIP-Seq_HELA_Human | 8.97999093 |
2 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 4.45702592 |
3 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.60910269 |
4 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 3.39457365 |
5 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.24157780 |
6 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.22012459 |
7 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.82719900 |
8 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.67093836 |
9 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.43697179 |
10 | MYC_22102868_ChIP-Seq_BL_Human | 2.39282983 |
11 | AR_21909140_ChIP-Seq_LNCAP_Human | 2.28550145 |
12 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.19977292 |
13 | ZNF263_19887448_ChIP-Seq_K562_Human | 2.10670976 |
14 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.09005678 |
15 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.05513554 |
16 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 1.99730345 |
17 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.97565349 |
18 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 1.93997508 |
19 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.93240512 |
20 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.92972454 |
21 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 1.86757720 |
22 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 1.86181984 |
23 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.83327843 |
24 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.82724356 |
25 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 1.81478456 |
26 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.78532799 |
27 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 1.77001237 |
28 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 1.72156551 |
29 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.67278227 |
30 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 1.66825151 |
31 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 1.66464815 |
32 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.66089828 |
33 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.65288367 |
34 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.61358386 |
35 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.60058298 |
36 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.57426546 |
37 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 1.56817911 |
38 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.54550766 |
39 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.54525680 |
40 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.50500976 |
41 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.50263468 |
42 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.48413544 |
43 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.48231545 |
44 | CLOCK_20551151_ChIP-Seq_293T_Human | 1.47708081 |
45 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.47478678 |
46 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.47325449 |
47 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.45866302 |
48 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.45042679 |
49 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.44021591 |
50 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.43931690 |
51 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.38645097 |
52 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.38359368 |
53 | HIF1A_21447827_ChIP-Seq_MCF-7_Human | 1.37189891 |
54 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 1.37109687 |
55 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.35884053 |
56 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.34198134 |
57 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.29230633 |
58 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.28184559 |
59 | SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse | 1.27896468 |
60 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.27066406 |
61 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.27029713 |
62 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.23371818 |
63 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 1.19474406 |
64 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.18542458 |
65 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.17786192 |
66 | PKCTHETA_26484144_Chip-Seq_BREAST_Human | 1.17685321 |
67 | KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.14020264 |
68 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 1.13913443 |
69 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 1.13689065 |
70 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.12414921 |
71 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.11682213 |
72 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.10543110 |
73 | CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.10140637 |
74 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.09207942 |
75 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.08768813 |
76 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.07450121 |
77 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 1.06847739 |
78 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 1.05954070 |
79 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 1.05032921 |
80 | NANOG_21062744_ChIP-ChIP_HESCs_Human | 1.04582602 |
81 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.04390440 |
82 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.03727424 |
83 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 1.03110149 |
84 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.01602124 |
85 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.01470434 |
86 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 1.01153787 |
87 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.01106083 |
88 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.00824804 |
89 | TRIM28_19339689_ChIP-ChIP_MESCs_Mouse | 1.00607003 |
90 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.00485482 |
91 | ZIC3_20872845_ChIP-ChIP_MESCs_Mouse | 0.99680370 |
92 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 0.98647407 |
93 | SPI1_23547873_ChIP-Seq_NB4_Human | 0.98481581 |
94 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 0.98212656 |
95 | UTX_26944678_Chip-Seq_JUKART_Human | 0.96905538 |
96 | RACK7_27058665_Chip-Seq_MCF-7_Human | 0.95337929 |
97 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 0.95182249 |
98 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 0.94866239 |
99 | NKX2-5_21415370_ChIP-Seq_HL-1_Mouse | 0.94806713 |
100 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.93990769 |
101 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.92378744 |
102 | EOMES_20176728_ChIP-ChIP_TSCs_Mouse | 0.91690720 |
103 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 0.91671492 |
104 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 0.91648637 |
105 | TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 0.91297471 |
106 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 0.91180572 |
107 | TCF7_22412390_ChIP-Seq_EML_Mouse | 0.90973146 |
108 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.90888817 |
109 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.90707868 |
110 | MAF_26560356_Chip-Seq_TH1_Human | 0.90616424 |
111 | CHD1_26751641_Chip-Seq_LNCaP_Human | 0.89386146 |
112 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.89350022 |
113 | MYB_26560356_Chip-Seq_TH1_Human | 0.89317474 |
114 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 0.89009219 |
115 | ATF3_27146783_Chip-Seq_COLON_Human | 0.88461084 |
116 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 0.87439622 |
117 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 0.86762604 |
118 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 0.86732327 |
119 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 0.86517432 |
120 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.86272906 |
121 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 0.86147887 |
122 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 0.85160397 |
123 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 0.84608455 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0003693_abnormal_embryo_hatching | 4.16469639 |
2 | MP0010094_abnormal_chromosome_stability | 3.95879432 |
3 | MP0003111_abnormal_nucleus_morphology | 3.85916103 |
4 | MP0004957_abnormal_blastocyst_morpholog | 3.70305439 |
5 | MP0003077_abnormal_cell_cycle | 3.33745315 |
6 | MP0010352_gastrointestinal_tract_polyps | 3.22280611 |
7 | MP0008057_abnormal_DNA_replication | 2.88628659 |
8 | MP0010234_abnormal_vibrissa_follicle | 2.75628093 |
9 | MP0004233_abnormal_muscle_weight | 2.51140855 |
10 | MP0003705_abnormal_hypodermis_morpholog | 2.40818539 |
11 | MP0001730_embryonic_growth_arrest | 2.37842406 |
12 | MP0005451_abnormal_body_composition | 2.34365125 |
13 | MP0003123_paternal_imprinting | 2.32797488 |
14 | MP0010307_abnormal_tumor_latency | 2.32073780 |
15 | MP0000350_abnormal_cell_proliferation | 2.29637071 |
16 | MP0008260_abnormal_autophagy | 2.26206289 |
17 | MP0008007_abnormal_cellular_replicative | 2.25072676 |
18 | MP0005076_abnormal_cell_differentiation | 2.13560580 |
19 | MP0008932_abnormal_embryonic_tissue | 2.07050978 |
20 | MP0005623_abnormal_meninges_morphology | 2.03632515 |
21 | MP0008058_abnormal_DNA_repair | 2.00198840 |
22 | MP0005380_embryogenesis_phenotype | 1.90206644 |
23 | MP0001672_abnormal_embryogenesis/_devel | 1.90206644 |
24 | MP0001697_abnormal_embryo_size | 1.81065825 |
25 | MP0003984_embryonic_growth_retardation | 1.79843613 |
26 | MP0002396_abnormal_hematopoietic_system | 1.78350473 |
27 | MP0002088_abnormal_embryonic_growth/wei | 1.77243864 |
28 | MP0002009_preneoplasia | 1.69413851 |
29 | MP0008877_abnormal_DNA_methylation | 1.67230668 |
30 | MP0004197_abnormal_fetal_growth/weight/ | 1.61743914 |
31 | MP0000490_abnormal_crypts_of | 1.60249622 |
32 | MP0003567_abnormal_fetal_cardiomyocyte | 1.60032023 |
33 | MP0002085_abnormal_embryonic_tissue | 1.59063652 |
34 | MP0002084_abnormal_developmental_patter | 1.58642638 |
35 | MP0000537_abnormal_urethra_morphology | 1.58298617 |
36 | MP0002086_abnormal_extraembryonic_tissu | 1.57685695 |
37 | MP0002080_prenatal_lethality | 1.56667010 |
38 | MP0006054_spinal_hemorrhage | 1.56514786 |
39 | MP0004808_abnormal_hematopoietic_stem | 1.55726089 |
40 | MP0009278_abnormal_bone_marrow | 1.55695859 |
41 | MP0003718_maternal_effect | 1.53767863 |
42 | MP0002796_impaired_skin_barrier | 1.50778914 |
43 | MP0005501_abnormal_skin_physiology | 1.49476733 |
44 | MP0001545_abnormal_hematopoietic_system | 1.45047851 |
45 | MP0005397_hematopoietic_system_phenotyp | 1.45047851 |
46 | MP0003941_abnormal_skin_development | 1.42961712 |
47 | MP0009840_abnormal_foam_cell | 1.40947948 |
48 | MP0002019_abnormal_tumor_incidence | 1.39641334 |
49 | MP0001915_intracranial_hemorrhage | 1.39333281 |
50 | MP0003303_peritoneal_inflammation | 1.38350943 |
51 | MP0003890_abnormal_embryonic-extraembry | 1.32122399 |
52 | MP0009333_abnormal_splenocyte_physiolog | 1.31820779 |
53 | MP0000313_abnormal_cell_death | 1.30389779 |
54 | MP0003566_abnormal_cell_adhesion | 1.30154117 |
55 | MP0000858_altered_metastatic_potential | 1.23150137 |
56 | MP0002398_abnormal_bone_marrow | 1.22222578 |
57 | MP0000733_abnormal_muscle_development | 1.20050936 |
58 | MP0003786_premature_aging | 1.19934057 |
59 | MP0003436_decreased_susceptibility_to | 1.17162936 |
60 | MP0005023_abnormal_wound_healing | 1.15657916 |
61 | MP0004272_abnormal_basement_membrane | 1.13216851 |
62 | MP0002098_abnormal_vibrissa_morphology | 1.12888173 |
63 | MP0003221_abnormal_cardiomyocyte_apopto | 1.12533206 |
64 | MP0001661_extended_life_span | 1.08162381 |
65 | MP0003121_genomic_imprinting | 1.07347677 |
66 | MP0000685_abnormal_immune_system | 1.07045806 |
67 | MP0010030_abnormal_orbit_morphology | 1.06773215 |
68 | MP0000689_abnormal_spleen_morphology | 1.06692577 |
69 | MP0002722_abnormal_immune_system | 1.06033235 |
70 | MP0002060_abnormal_skin_morphology | 1.05457594 |
71 | MP0002877_abnormal_melanocyte_morpholog | 1.04981924 |
72 | MP0004264_abnormal_extraembryonic_tissu | 1.04532868 |
73 | MP0000703_abnormal_thymus_morphology | 1.04211184 |
74 | MP0006035_abnormal_mitochondrial_morpho | 1.03363050 |
75 | MP0003453_abnormal_keratinocyte_physiol | 1.01654854 |
76 | MP0002697_abnormal_eye_size | 1.00834104 |
77 | MP0000747_muscle_weakness | 1.00776303 |
78 | MP0000579_abnormal_nail_morphology | 1.00448142 |
79 | MP0003315_abnormal_perineum_morphology | 0.99425073 |
80 | MP0001346_abnormal_lacrimal_gland | 0.99401810 |
81 | MP0005621_abnormal_cell_physiology | 0.98895157 |
82 | MP0000358_abnormal_cell_content/ | 0.98041402 |
83 | MP0003806_abnormal_nucleotide_metabolis | 0.98021397 |
84 | MP0005058_abnormal_lysosome_morphology | 0.97249646 |
85 | MP0001293_anophthalmia | 0.96570403 |
86 | MP0005384_cellular_phenotype | 0.95827614 |
87 | MP0003448_altered_tumor_morphology | 0.95322525 |
88 | MP0002210_abnormal_sex_determination | 0.94306386 |
89 | MP0002006_tumorigenesis | 0.94110468 |
90 | MP0002269_muscular_atrophy | 0.93555515 |
91 | MP0001216_abnormal_epidermal_layer | 0.93218943 |
92 | MP0002429_abnormal_blood_cell | 0.92933845 |
93 | MP0001800_abnormal_humoral_immune | 0.92739644 |
94 | MP0009053_abnormal_anal_canal | 0.91000277 |
95 | MP0000627_abnormal_mammary_gland | 0.89041459 |
96 | MP0000716_abnormal_immune_system | 0.87781226 |
97 | MP0002653_abnormal_ependyma_morphology | 0.87748049 |
98 | MP0003115_abnormal_respiratory_system | 0.87165719 |
99 | MP0008438_abnormal_cutaneous_collagen | 0.87026835 |
100 | MP0000428_abnormal_craniofacial_morphol | 0.86729153 |
101 | MP0001145_abnormal_male_reproductive | 0.85966253 |
102 | MP0002452_abnormal_antigen_presenting | 0.85918614 |
103 | MP0001835_abnormal_antigen_presentation | 0.85137977 |
104 | MP0009672_abnormal_birth_weight | 0.84677804 |
105 | MP0000003_abnormal_adipose_tissue | 0.84098847 |
106 | MP0001929_abnormal_gametogenesis | 0.83522545 |
107 | MP0001727_abnormal_embryo_implantation | 0.83140055 |
108 | MP0004185_abnormal_adipocyte_glucose | 0.83113030 |
109 | MP0003763_abnormal_thymus_physiology | 0.81798899 |
110 | MP0000377_abnormal_hair_follicle | 0.79925539 |
111 | MP0003385_abnormal_body_wall | 0.79642314 |
112 | MP0002166_altered_tumor_susceptibility | 0.79635992 |
113 | MP0003656_abnormal_erythrocyte_physiolo | 0.79592000 |
114 | MP0000653_abnormal_sex_gland | 0.79510575 |
115 | MP0003935_abnormal_craniofacial_develop | 0.79206912 |
116 | MP0003191_abnormal_cellular_cholesterol | 0.79140255 |
117 | MP0002723_abnormal_immune_serum | 0.78748447 |
118 | MP0002089_abnormal_postnatal_growth/wei | 0.78644631 |
119 | MP0000467_abnormal_esophagus_morphology | 0.78277527 |
120 | MP0000750_abnormal_muscle_regeneration | 0.78102188 |
121 | MP0003943_abnormal_hepatobiliary_system | 0.77772921 |
122 | MP0001119_abnormal_female_reproductive | 0.77675336 |
123 | MP0001348_abnormal_lacrimal_gland | 0.77106841 |
124 | MP0003942_abnormal_urinary_system | 0.77074050 |
125 | MP0003091_abnormal_cell_migration | 0.76795425 |
126 | MP0005257_abnormal_intraocular_pressure | 0.76754628 |
127 | MP0001819_abnormal_immune_cell | 0.76557477 |
128 | MP0010630_abnormal_cardiac_muscle | 0.76465084 |
129 | MP0002420_abnormal_adaptive_immunity | 0.76172795 |
130 | MP0000477_abnormal_intestine_morphology | 0.75326915 |
131 | MP0009697_abnormal_copulation | 0.73819213 |
132 | MP0003119_abnormal_digestive_system | 0.73617085 |
133 | MP0002751_abnormal_autonomic_nervous | 0.73398872 |
134 | MP0001849_ear_inflammation | 0.73353982 |
135 | MP0004947_skin_inflammation | 0.73232572 |
136 | MP0000762_abnormal_tongue_morphology | 0.70588755 |
137 | MP0000759_abnormal_skeletal_muscle | 0.70482182 |
138 | MP0004782_abnormal_surfactant_physiolog | 0.69160429 |
139 | MP0009703_decreased_birth_body | 0.69080657 |
140 | MP0002405_respiratory_system_inflammati | 0.68407927 |
141 | MP0002092_abnormal_eye_morphology | 0.68372287 |
142 | MP0003937_abnormal_limbs/digits/tail_de | 0.67595996 |
143 | MP0005197_abnormal_uvea_morphology | 0.67261062 |
144 | MP0002111_abnormal_tail_morphology | 0.67124536 |
145 | MP0005000_abnormal_immune_tolerance | 0.65824087 |
146 | MP0010678_abnormal_skin_adnexa | 0.64827711 |
147 | MP0003699_abnormal_female_reproductive | 0.64219823 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Asymmetry of the thorax (HP:0001555) | 4.09783317 |
2 | Birth length less than 3rd percentile (HP:0003561) | 3.66257132 |
3 | Ependymoma (HP:0002888) | 3.37866900 |
4 | Breast hypoplasia (HP:0003187) | 3.30591472 |
5 | Microvesicular hepatic steatosis (HP:0001414) | 3.30576107 |
6 | Progressive external ophthalmoplegia (HP:0000590) | 3.24950827 |
7 | Abnormality of the anterior horn cell (HP:0006802) | 3.18273412 |
8 | Degeneration of anterior horn cells (HP:0002398) | 3.18273412 |
9 | Medulloblastoma (HP:0002885) | 3.18271385 |
10 | Agnosia (HP:0010524) | 3.17015877 |
11 | Colon cancer (HP:0003003) | 3.02791206 |
12 | Chromsome breakage (HP:0040012) | 2.99901143 |
13 | Rhabdomyosarcoma (HP:0002859) | 2.97748376 |
14 | Elevated erythrocyte sedimentation rate (HP:0003565) | 2.95697517 |
15 | Peritonitis (HP:0002586) | 2.93405208 |
16 | Progressive muscle weakness (HP:0003323) | 2.90508555 |
17 | Insidious onset (HP:0003587) | 2.86404887 |
18 | Termporal pattern (HP:0011008) | 2.86404887 |
19 | Selective tooth agenesis (HP:0001592) | 2.84396225 |
20 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.81386564 |
21 | Ragged-red muscle fibers (HP:0003200) | 2.77738015 |
22 | Facial hemangioma (HP:0000329) | 2.66581641 |
23 | Patellar aplasia (HP:0006443) | 2.64634391 |
24 | Cortical dysplasia (HP:0002539) | 2.63115109 |
25 | Microglossia (HP:0000171) | 2.62584768 |
26 | Abnormality of the labia minora (HP:0012880) | 2.58688826 |
27 | Micronodular cirrhosis (HP:0001413) | 2.58685249 |
28 | Septate vagina (HP:0001153) | 2.58380543 |
29 | Spinal cord lesions (HP:0100561) | 2.58235859 |
30 | Syringomyelia (HP:0003396) | 2.58235859 |
31 | Abnormality of the peritoneum (HP:0002585) | 2.57061824 |
32 | Short nail (HP:0001799) | 2.56094438 |
33 | Pelvic girdle muscle weakness (HP:0003749) | 2.50611039 |
34 | Deep philtrum (HP:0002002) | 2.48248078 |
35 | Aplasia/Hypoplasia of the patella (HP:0006498) | 2.45013247 |
36 | Hyperacusis (HP:0010780) | 2.44854336 |
37 | Deviation of the thumb (HP:0009603) | 2.42086856 |
38 | Carpal bone hypoplasia (HP:0001498) | 2.41239604 |
39 | Long palpebral fissure (HP:0000637) | 2.39306251 |
40 | Astrocytoma (HP:0009592) | 2.39015171 |
41 | Abnormality of the astrocytes (HP:0100707) | 2.39015171 |
42 | Proximal placement of thumb (HP:0009623) | 2.37350737 |
43 | Premature ovarian failure (HP:0008209) | 2.36864009 |
44 | Reticulocytopenia (HP:0001896) | 2.35100340 |
45 | Overlapping toe (HP:0001845) | 2.32257480 |
46 | Neoplasm of striated muscle (HP:0009728) | 2.31874356 |
47 | Prominent nose (HP:0000448) | 2.30700472 |
48 | Multiple enchondromatosis (HP:0005701) | 2.30351669 |
49 | Cerebral hypomyelination (HP:0006808) | 2.28241117 |
50 | Neoplasm of the pancreas (HP:0002894) | 2.26932493 |
51 | Impulsivity (HP:0100710) | 2.21203246 |
52 | Decreased number of large peripheral myelinated nerve fibers (HP:0003387) | 2.20569737 |
53 | Basal cell carcinoma (HP:0002671) | 2.20246600 |
54 | Cholecystitis (HP:0001082) | 2.20211451 |
55 | Abnormal gallbladder physiology (HP:0012438) | 2.20211451 |
56 | Malignant gastrointestinal tract tumors (HP:0006749) | 2.19005323 |
57 | Gastrointestinal carcinoma (HP:0002672) | 2.19005323 |
58 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.17302212 |
59 | Abnormality of chromosome stability (HP:0003220) | 2.16802612 |
60 | Orthostatic hypotension (HP:0001278) | 2.14881314 |
61 | Abnormality of the umbilical cord (HP:0010881) | 2.14130119 |
62 | Abnormality of the distal phalanges of the toes (HP:0010182) | 2.11207260 |
63 | Biliary tract neoplasm (HP:0100574) | 2.10709965 |
64 | Shoulder girdle muscle weakness (HP:0003547) | 2.08175608 |
65 | Abnormality of glycolysis (HP:0004366) | 2.08061222 |
66 | Meckel diverticulum (HP:0002245) | 2.06745075 |
67 | Cafe-au-lait spot (HP:0000957) | 2.06626587 |
68 | Absent radius (HP:0003974) | 2.06395150 |
69 | High pitched voice (HP:0001620) | 2.06314033 |
70 | Amaurosis fugax (HP:0100576) | 2.04799367 |
71 | Increased nuchal translucency (HP:0010880) | 2.03482075 |
72 | Abnormality of the musculature of the pelvis (HP:0001469) | 2.01515879 |
73 | Abnormality of the hip-girdle musculature (HP:0001445) | 2.01515879 |
74 | Premature rupture of membranes (HP:0001788) | 2.00824791 |
75 | Myelodysplasia (HP:0002863) | 1.99712306 |
76 | Abnormality of the fetal cardiovascular system (HP:0010948) | 1.99095470 |
77 | Abnormal umbilical cord blood vessels (HP:0011403) | 1.99095470 |
78 | Single umbilical artery (HP:0001195) | 1.99095470 |
79 | Ectopic kidney (HP:0000086) | 1.98796046 |
80 | Abnormality of the ileum (HP:0001549) | 1.98190773 |
81 | Rough bone trabeculation (HP:0100670) | 1.97790871 |
82 | Increased density of long bones (HP:0006392) | 1.96490357 |
83 | Aplasia/hypoplasia of the humerus (HP:0006507) | 1.96464421 |
84 | Poikiloderma (HP:0001029) | 1.94540236 |
85 | Oral leukoplakia (HP:0002745) | 1.94435253 |
86 | Glioma (HP:0009733) | 1.92529150 |
87 | Neoplasm of the oral cavity (HP:0100649) | 1.92062606 |
88 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 1.91557588 |
89 | Back pain (HP:0003418) | 1.91145834 |
90 | Sparse lateral eyebrow (HP:0005338) | 1.90993368 |
91 | Leiomyosarcoma (HP:0100243) | 1.90361940 |
92 | Uterine leiomyosarcoma (HP:0002891) | 1.90361940 |
93 | Genu recurvatum (HP:0002816) | 1.87632733 |
94 | High anterior hairline (HP:0009890) | 1.87593634 |
95 | Vertebral compression fractures (HP:0002953) | 1.87345308 |
96 | Insomnia (HP:0100785) | 1.86726557 |
97 | Ankle contracture (HP:0006466) | 1.86368929 |
98 | Abnormality of the fingertips (HP:0001211) | 1.86298095 |
99 | Absent forearm bone (HP:0003953) | 1.86103666 |
100 | Aplasia involving forearm bones (HP:0009822) | 1.86103666 |
101 | Spastic diplegia (HP:0001264) | 1.85093477 |
102 | Secondary amenorrhea (HP:0000869) | 1.84947365 |
103 | Hereditary nonpolyposis colorectal carcinoma (HP:0006716) | 1.84445439 |
104 | Uterine neoplasm (HP:0010784) | 1.84168092 |
105 | Natal tooth (HP:0000695) | 1.83012219 |
106 | Increased connective tissue (HP:0009025) | 1.81366102 |
107 | Advanced eruption of teeth (HP:0006288) | 1.81111666 |
108 | Abnormality of pyrimidine metabolism (HP:0004353) | 1.80932362 |
109 | Capillary hemangiomas (HP:0005306) | 1.80747939 |
110 | Ankyloglossia (HP:0010296) | 1.80621589 |
111 | Progressive hearing impairment (HP:0001730) | 1.79960877 |
112 | Sloping forehead (HP:0000340) | 1.79716817 |
113 | Thrombocytosis (HP:0001894) | 1.79450124 |
114 | Abnormalities of placenta or umbilical cord (HP:0001194) | 1.77937854 |
115 | Protrusio acetabuli (HP:0003179) | 1.77779182 |
116 | Trismus (HP:0000211) | 1.77337685 |
117 | Flat acetabular roof (HP:0003180) | 1.76561256 |
118 | Personality changes (HP:0000751) | 1.76097537 |
119 | Missing ribs (HP:0000921) | 1.75083809 |
120 | Increased serum pyruvate (HP:0003542) | 1.74551965 |
121 | Renal cell carcinoma (HP:0005584) | 1.73944555 |
122 | Ulnar bowing (HP:0003031) | 1.73289248 |
123 | Long eyelashes (HP:0000527) | 1.73015585 |
124 | Curly hair (HP:0002212) | 1.72978267 |
125 | Nephroblastoma (Wilms tumor) (HP:0002667) | 1.72851945 |
126 | Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042) | 1.72764879 |
127 | Short 4th metacarpal (HP:0010044) | 1.72764879 |
128 | Abnormality of the calcaneus (HP:0008364) | 1.72722822 |
129 | Shallow orbits (HP:0000586) | 1.72552368 |
130 | Spinal muscular atrophy (HP:0007269) | 1.72386917 |
131 | Glossoptosis (HP:0000162) | 1.72384432 |
132 | Tracheoesophageal fistula (HP:0002575) | 1.72021803 |
133 | Short humerus (HP:0005792) | 1.71977489 |
134 | Cutaneous melanoma (HP:0012056) | 1.71302691 |
135 | Subacute progressive viral hepatitis (HP:0006572) | 1.70474756 |
136 | Recurrent viral infections (HP:0004429) | 1.70104600 |
137 | Small intestinal stenosis (HP:0012848) | 1.69632360 |
138 | Duodenal stenosis (HP:0100867) | 1.69632360 |
139 | Heterotopia (HP:0002282) | 1.69486102 |
140 | Osteolytic defects of the phalanges of the hand (HP:0009771) | 1.69396861 |
141 | Osteolytic defects of the hand bones (HP:0009699) | 1.69396861 |
142 | Absent thumb (HP:0009777) | 1.69126986 |
143 | Entropion (HP:0000621) | 1.67850359 |
144 | Angiofibromas (HP:0010615) | 1.67270027 |
145 | Adenoma sebaceum (HP:0009720) | 1.67270027 |
146 | Abnormal foot bone ossification (HP:0010675) | 1.67183950 |
147 | Slender long bone (HP:0003100) | 1.66248854 |
148 | Atresia of the external auditory canal (HP:0000413) | 1.65849134 |
149 | Squamous cell carcinoma (HP:0002860) | 1.65813395 |
150 | Upper motor neuron abnormality (HP:0002127) | 1.65529161 |
151 | 11 pairs of ribs (HP:0000878) | 1.65070658 |
152 | Reticulocytosis (HP:0001923) | 1.63797656 |
153 | Abnormality of the preputium (HP:0100587) | 1.63698258 |
154 | Stenosis of the external auditory canal (HP:0000402) | 1.63634438 |
155 | Abnormality of oral frenula (HP:0000190) | 1.63280799 |
156 | Fatigue (HP:0012378) | 1.60991503 |
157 | Broad distal phalanx of finger (HP:0009836) | 1.59796761 |
158 | Embryonal renal neoplasm (HP:0011794) | 1.59546012 |
159 | Impaired proprioception (HP:0010831) | 1.57207059 |
160 | Hammertoe (HP:0001765) | 1.56581241 |
161 | Upper limb muscle weakness (HP:0003484) | 1.55198711 |
162 | Papillary thyroid carcinoma (HP:0002895) | 1.54195720 |
163 | Transitional cell carcinoma of the bladder (HP:0006740) | 1.53488852 |
164 | Abnormality of the phalanges of the hallux (HP:0010057) | 1.53433799 |
165 | Athetosis (HP:0002305) | 1.51565381 |
166 | Achilles tendon contracture (HP:0001771) | 1.49230253 |
167 | Hypopigmentation of the fundus (HP:0007894) | 1.48022688 |
Rank | Gene Set | Z-score |
---|---|---|
1 | CDC7 | 3.70211990 |
2 | WEE1 | 3.25318663 |
3 | CDK12 | 3.10671783 |
4 | NEK2 | 3.09550758 |
5 | SMG1 | 2.86360122 |
6 | STK10 | 2.70791673 |
7 | BUB1 | 2.68577952 |
8 | MAP3K10 | 2.36125773 |
9 | RPS6KA4 | 2.32653088 |
10 | EIF2AK1 | 2.28006749 |
11 | TTK | 2.27603931 |
12 | PBK | 2.08709021 |
13 | CDK4 | 1.98717748 |
14 | ICK | 1.98056571 |
15 | EEF2K | 1.95991612 |
16 | NEK1 | 1.95744271 |
17 | MAP3K8 | 1.94635250 |
18 | DYRK3 | 1.91450466 |
19 | IRAK3 | 1.91024759 |
20 | NME2 | 1.82003999 |
21 | PKN2 | 1.79332572 |
22 | ACVR1B | 1.76180365 |
23 | PLK1 | 1.69857035 |
24 | SIK1 | 1.66936108 |
25 | SCYL2 | 1.64114823 |
26 | BRSK2 | 1.59447110 |
27 | PRPF4B | 1.52748600 |
28 | TRIB3 | 1.52579206 |
29 | TESK2 | 1.49259976 |
30 | STK3 | 1.48718854 |
31 | CHEK2 | 1.48599093 |
32 | TRIM28 | 1.45864634 |
33 | FLT3 | 1.45133618 |
34 | KSR2 | 1.44736504 |
35 | EPHA2 | 1.43637830 |
36 | SRPK1 | 1.39795631 |
37 | ATR | 1.37138819 |
38 | CDK7 | 1.36536171 |
39 | AURKB | 1.35818010 |
40 | TSSK6 | 1.34922646 |
41 | LRRK2 | 1.31691464 |
42 | PLK4 | 1.30656433 |
43 | PLK3 | 1.29068503 |
44 | LATS2 | 1.26920775 |
45 | PAK4 | 1.23575608 |
46 | RAF1 | 1.18535112 |
47 | RPS6KB2 | 1.14169103 |
48 | ALK | 1.13177638 |
49 | CHEK1 | 1.11980468 |
50 | CDK6 | 1.11363591 |
51 | PIM1 | 1.11272334 |
52 | MAP3K11 | 1.06942197 |
53 | TGFBR1 | 1.02808615 |
54 | MTOR | 1.01955077 |
55 | SIK3 | 1.01766576 |
56 | LATS1 | 1.01385499 |
57 | MOS | 1.00644201 |
58 | PASK | 0.99531528 |
59 | TLK1 | 0.99078364 |
60 | IRAK2 | 0.94592580 |
61 | MELK | 0.90808242 |
62 | MST1R | 0.89978684 |
63 | STK4 | 0.89701567 |
64 | NEK6 | 0.88608768 |
65 | YES1 | 0.85895469 |
66 | MAP4K1 | 0.84867147 |
67 | CDK2 | 0.84823357 |
68 | MKNK1 | 0.81527364 |
69 | FGFR4 | 0.80700352 |
70 | AURKA | 0.78858085 |
71 | JAK3 | 0.78687493 |
72 | NEK9 | 0.78391558 |
73 | NUAK1 | 0.77137544 |
74 | PTK6 | 0.76681069 |
75 | ATM | 0.74228008 |
76 | PDK2 | 0.73509022 |
77 | TTN | 0.70555983 |
78 | ZAP70 | 0.70254535 |
79 | BRSK1 | 0.69563120 |
80 | RPS6KB1 | 0.67624300 |
81 | MAP3K5 | 0.67415862 |
82 | EIF2AK3 | 0.66176601 |
83 | PTK2 | 0.65559363 |
84 | ERN1 | 0.64085518 |
85 | BRD4 | 0.63915052 |
86 | GRK6 | 0.60043301 |
87 | TAOK3 | 0.59968224 |
88 | TAOK2 | 0.59765570 |
89 | TESK1 | 0.58883459 |
90 | PDGFRA | 0.57891634 |
91 | ARAF | 0.56504213 |
92 | PAK1 | 0.55930784 |
93 | BCR | 0.55507470 |
94 | CDK1 | 0.55324286 |
95 | MET | 0.55200737 |
96 | BMX | 0.54898154 |
97 | CLK1 | 0.53231655 |
98 | MKNK2 | 0.52607659 |
99 | CSNK1A1L | 0.52348057 |
100 | CSNK1G3 | 0.52263026 |
101 | KSR1 | 0.52125873 |
102 | BRAF | 0.52121862 |
103 | EIF2AK2 | 0.52113957 |
104 | MAP2K7 | 0.51733506 |
105 | MAP3K9 | 0.51227057 |
106 | CDK9 | 0.49080613 |
107 | CHUK | 0.47888507 |
108 | CSF1R | 0.47233659 |
109 | PAK2 | 0.47150197 |
110 | TAF1 | 0.46788974 |
111 | VRK1 | 0.46711108 |
112 | CSNK2A2 | 0.46224246 |
113 | DYRK1B | 0.46194141 |
114 | ERBB4 | 0.45695951 |
115 | BLK | 0.44198754 |
116 | MAPK11 | 0.43939806 |
117 | CAMK1G | 0.42950986 |
118 | CDK18 | 0.41306555 |
119 | STK16 | 0.41229026 |
120 | RET | 0.39794380 |
121 | TYK2 | 0.39760168 |
122 | CAMK1D | 0.39731165 |
123 | PIM2 | 0.39238746 |
124 | CDK15 | 0.39179216 |
125 | CSNK1G1 | 0.38300818 |
126 | MAP3K14 | 0.37709872 |
127 | TYRO3 | 0.37352404 |
128 | AKT2 | 0.36998309 |
129 | PRKD3 | 0.36979326 |
130 | TBK1 | 0.36661086 |
131 | BTK | 0.35847401 |
132 | CDK14 | 0.35730153 |
133 | RPS6KA1 | 0.33499241 |
134 | RPS6KA5 | 0.33324822 |
135 | CSNK1E | 0.33144487 |
136 | MAP2K3 | 0.32982313 |
137 | TAOK1 | 0.32904497 |
138 | IKBKB | 0.32651903 |
139 | EPHB2 | 0.32325196 |
140 | RIPK1 | 0.29939667 |
141 | PRKDC | 0.29531966 |
142 | FGFR1 | 0.29043058 |
Rank | Gene Set | Z-score |
---|---|---|
1 | DNA replication_Homo sapiens_hsa03030 | 3.88348248 |
2 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.24259885 |
3 | Mismatch repair_Homo sapiens_hsa03430 | 3.17226797 |
4 | RNA transport_Homo sapiens_hsa03013 | 3.14314770 |
5 | Cell cycle_Homo sapiens_hsa04110 | 2.87123179 |
6 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.61806655 |
7 | Spliceosome_Homo sapiens_hsa03040 | 2.56010242 |
8 | Base excision repair_Homo sapiens_hsa03410 | 2.45201448 |
9 | RNA polymerase_Homo sapiens_hsa03020 | 2.12599488 |
10 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.05588461 |
11 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.01454367 |
12 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.97902002 |
13 | Homologous recombination_Homo sapiens_hsa03440 | 1.96118356 |
14 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.85959704 |
15 | Proteasome_Homo sapiens_hsa03050 | 1.76359143 |
16 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.70234136 |
17 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.68237797 |
18 | Basal transcription factors_Homo sapiens_hsa03022 | 1.52824022 |
19 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.49851173 |
20 | Ribosome_Homo sapiens_hsa03010 | 1.48867938 |
21 | RNA degradation_Homo sapiens_hsa03018 | 1.46996119 |
22 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.42663574 |
23 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 1.42432696 |
24 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 1.39944576 |
25 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 1.38481225 |
26 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.37557307 |
27 | Endometrial cancer_Homo sapiens_hsa05213 | 1.34991813 |
28 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.34959300 |
29 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.34412072 |
30 | Viral carcinogenesis_Homo sapiens_hsa05203 | 1.31128026 |
31 | Legionellosis_Homo sapiens_hsa05134 | 1.29908726 |
32 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 1.22520470 |
33 | Small cell lung cancer_Homo sapiens_hsa05222 | 1.18548454 |
34 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 1.18462912 |
35 | Sulfur relay system_Homo sapiens_hsa04122 | 1.14920473 |
36 | Oocyte meiosis_Homo sapiens_hsa04114 | 1.12632734 |
37 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.10602794 |
38 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.08388846 |
39 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 1.05730252 |
40 | Apoptosis_Homo sapiens_hsa04210 | 1.04939220 |
41 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 1.04078375 |
42 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 1.02911664 |
43 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.00992209 |
44 | HTLV-I infection_Homo sapiens_hsa05166 | 1.00080865 |
45 | Alcoholism_Homo sapiens_hsa05034 | 0.98514075 |
46 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.98195473 |
47 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.97332967 |
48 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.95735105 |
49 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.93956912 |
50 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.93036981 |
51 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.92834771 |
52 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.89528415 |
53 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.89410587 |
54 | Thyroid cancer_Homo sapiens_hsa05216 | 0.89109547 |
55 | Colorectal cancer_Homo sapiens_hsa05210 | 0.88854841 |
56 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.88483917 |
57 | Leishmaniasis_Homo sapiens_hsa05140 | 0.87935869 |
58 | Hepatitis B_Homo sapiens_hsa05161 | 0.86959202 |
59 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.84963318 |
60 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.84245367 |
61 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.83056404 |
62 | Shigellosis_Homo sapiens_hsa05131 | 0.80055680 |
63 | Viral myocarditis_Homo sapiens_hsa05416 | 0.80019068 |
64 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.79821407 |
65 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.77760552 |
66 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.77062495 |
67 | Galactose metabolism_Homo sapiens_hsa00052 | 0.76503668 |
68 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.75555638 |
69 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.75381768 |
70 | Glioma_Homo sapiens_hsa05214 | 0.74295741 |
71 | Measles_Homo sapiens_hsa05162 | 0.74135856 |
72 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.73538342 |
73 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.72424655 |
74 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.72377272 |
75 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.70942134 |
76 | Influenza A_Homo sapiens_hsa05164 | 0.70861650 |
77 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.70637971 |
78 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.69820588 |
79 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.69428204 |
80 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.67737177 |
81 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.67686823 |
82 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 0.67527129 |
83 | Bladder cancer_Homo sapiens_hsa05219 | 0.66440214 |
84 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.65388969 |
85 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.64938362 |
86 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.64887654 |
87 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.64856287 |
88 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.64220604 |
89 | Other glycan degradation_Homo sapiens_hsa00511 | 0.64202977 |
90 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.62619683 |
91 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.61735322 |
92 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.61629759 |
93 | Adherens junction_Homo sapiens_hsa04520 | 0.60222607 |
94 | Hepatitis C_Homo sapiens_hsa05160 | 0.60109142 |
95 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.58850188 |
96 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.58294869 |
97 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.56537513 |
98 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.55932695 |
99 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.55175482 |
100 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.54302980 |
101 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.54179524 |
102 | Purine metabolism_Homo sapiens_hsa00230 | 0.53069909 |
103 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.52965273 |
104 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.52870940 |
105 | Osteoclast differentiation_Homo sapiens_hsa04380 | 0.52656848 |
106 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.52182622 |
107 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.51681259 |
108 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.51654152 |
109 | Melanoma_Homo sapiens_hsa05218 | 0.49134093 |
110 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 0.48745827 |
111 | Prostate cancer_Homo sapiens_hsa05215 | 0.48153091 |
112 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.48104073 |
113 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.46564314 |
114 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.46368565 |
115 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.45540230 |
116 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.44623274 |
117 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.43787882 |
118 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.41713477 |
119 | Focal adhesion_Homo sapiens_hsa04510 | 0.41467289 |
120 | Pathways in cancer_Homo sapiens_hsa05200 | 0.41315090 |
121 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.40254655 |
122 | Tuberculosis_Homo sapiens_hsa05152 | 0.39680371 |
123 | Lysine degradation_Homo sapiens_hsa00310 | 0.38438320 |
124 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.36350553 |
125 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.36133727 |
126 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.35200048 |
127 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.34068675 |
128 | Salmonella infection_Homo sapiens_hsa05132 | 0.33482488 |
129 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.32901233 |
130 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.32625632 |
131 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.32188508 |
132 | Carbon metabolism_Homo sapiens_hsa01200 | 0.31025895 |