SMG8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)5.13811964
2COPI coating of Golgi vesicle (GO:0048205)5.13811964
3protein localization to kinetochore (GO:0034501)4.89243771
4nuclear pore organization (GO:0006999)4.85801121
5nuclear pore complex assembly (GO:0051292)4.81539212
6DNA unwinding involved in DNA replication (GO:0006268)4.80719618
7mitotic nuclear envelope disassembly (GO:0007077)4.64688508
8spliceosomal tri-snRNP complex assembly (GO:0000244)4.53349221
9folic acid-containing compound biosynthetic process (GO:0009396)4.46215386
10membrane disassembly (GO:0030397)4.35629946
11nuclear envelope disassembly (GO:0051081)4.35629946
12protein localization to chromosome, centromeric region (GO:0071459)4.16696129
13mitotic metaphase plate congression (GO:0007080)4.12340713
14DNA replication checkpoint (GO:0000076)4.08018307
15formation of translation preinitiation complex (GO:0001731)3.98162785
16pre-miRNA processing (GO:0031054)3.95535810
17DNA replication initiation (GO:0006270)3.94086874
18nucleobase biosynthetic process (GO:0046112)3.84485399
19DNA strand elongation involved in DNA replication (GO:0006271)3.84015478
20mitotic chromosome condensation (GO:0007076)3.75817877
21regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.71019254
22regulation of spindle organization (GO:0090224)3.70220972
23DNA replication-dependent nucleosome organization (GO:0034723)3.69954450
24DNA replication-dependent nucleosome assembly (GO:0006335)3.69954450
25ribosome assembly (GO:0042255)3.66251607
26DNA strand elongation (GO:0022616)3.65351799
27positive regulation of chromosome segregation (GO:0051984)3.63339092
28pore complex assembly (GO:0046931)3.62754533
29negative regulation of histone methylation (GO:0031061)3.61754191
30proline biosynthetic process (GO:0006561)3.60613333
31establishment of integrated proviral latency (GO:0075713)3.56509670
32heterochromatin organization (GO:0070828)3.55807091
33IMP biosynthetic process (GO:0006188)3.53206243
34purine nucleobase biosynthetic process (GO:0009113)3.51927366
35metaphase plate congression (GO:0051310)3.49468324
36nuclear envelope organization (GO:0006998)3.49417522
37regulation of mitotic spindle organization (GO:0060236)3.45017282
38regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.44459058
39regulation of mammary gland epithelial cell proliferation (GO:0033599)3.37558590
40protein complex localization (GO:0031503)3.36974607
41mitotic sister chromatid segregation (GO:0000070)3.31982845
42histone H2A monoubiquitination (GO:0035518)3.31391837
43COPII vesicle coating (GO:0048208)3.30813147
44regulation of RNA export from nucleus (GO:0046831)3.30346843
45protein localization to chromosome (GO:0034502)3.26305075
46peptidyl-arginine omega-N-methylation (GO:0035247)3.24004907
47DNA duplex unwinding (GO:0032508)3.23514711
48IMP metabolic process (GO:0046040)3.22871358
49cellular protein complex localization (GO:0034629)3.22366067
50regulation of histone H3-K9 methylation (GO:0051570)3.21769914
51DNA geometric change (GO:0032392)3.21006204
52retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.20881552
53regulation of sister chromatid cohesion (GO:0007063)3.18240172
54sister chromatid segregation (GO:0000819)3.17465535
55attachment of spindle microtubules to kinetochore (GO:0008608)3.13254439
56mitochondrial DNA metabolic process (GO:0032042)3.11885605
57regulation of translational termination (GO:0006449)3.10133605
58regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.09271430
59establishment of chromosome localization (GO:0051303)3.07405235
60regulation of chromosome segregation (GO:0051983)3.05050253
61regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.04194359
62maturation of SSU-rRNA (GO:0030490)3.03019608
63negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.01903709
64negative regulation of chromosome segregation (GO:0051985)2.99731244
65folic acid metabolic process (GO:0046655)2.99233005
66protein K6-linked ubiquitination (GO:0085020)2.97463986
67ribosome biogenesis (GO:0042254)2.96846166
68spindle checkpoint (GO:0031577)2.96823926
69telomere maintenance via semi-conservative replication (GO:0032201)2.96641563
70mitotic sister chromatid cohesion (GO:0007064)2.96319648
71regulation of mitotic metaphase/anaphase transition (GO:0030071)2.96312542
72mitotic spindle checkpoint (GO:0071174)2.95481738
73double-strand break repair via nonhomologous end joining (GO:0006303)2.95328984
74non-recombinational repair (GO:0000726)2.95328984
75establishment of viral latency (GO:0019043)2.94398008
76mitotic spindle assembly checkpoint (GO:0007094)2.93270304
77chromatin assembly (GO:0031497)2.93268625
78peptidyl-arginine methylation (GO:0018216)2.91733446
79peptidyl-arginine N-methylation (GO:0035246)2.91733446
80negative regulation of mitotic sister chromatid separation (GO:2000816)2.91564048
81negative regulation of mitotic sister chromatid segregation (GO:0033048)2.91564048
82negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.91564048
83negative regulation of sister chromatid segregation (GO:0033046)2.91564048
84spindle assembly checkpoint (GO:0071173)2.90133611
85chromatin assembly or disassembly (GO:0006333)2.88263291
86protein export from nucleus (GO:0006611)2.88093343
87positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.86066927
88positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.86066927
89positive regulation of mitotic sister chromatid separation (GO:1901970)2.86066927
90mitochondrial fusion (GO:0008053)2.82867520
91regulation of translational fidelity (GO:0006450)2.81111869
92snRNA metabolic process (GO:0016073)2.80681442
93maturation of 5.8S rRNA (GO:0000460)2.80214274
94translesion synthesis (GO:0019985)2.79992130
95regulation of NFAT protein import into nucleus (GO:0051532)2.78950174
96mitotic recombination (GO:0006312)2.77933983
97telomere maintenance via recombination (GO:0000722)2.77826494
98histone arginine methylation (GO:0034969)2.76873265
99regulation of centriole replication (GO:0046599)2.74660254
100tRNA aminoacylation for protein translation (GO:0006418)2.72560309
101gene silencing by RNA (GO:0031047)2.71260187
102negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.70454234
103vesicle coating (GO:0006901)2.69497683
104kinetochore organization (GO:0051383)2.69479228
105DNA synthesis involved in DNA repair (GO:0000731)2.67523989
106inner cell mass cell proliferation (GO:0001833)2.66557479
107regulation of posttranscriptional gene silencing (GO:0060147)2.66017101
108regulation of gene silencing by miRNA (GO:0060964)2.66017101
109regulation of gene silencing by RNA (GO:0060966)2.66017101
110DNA replication-independent nucleosome assembly (GO:0006336)2.65573985
111DNA replication-independent nucleosome organization (GO:0034724)2.65573985
112regulation of DNA damage checkpoint (GO:2000001)2.65214617
113regulation of sister chromatid segregation (GO:0033045)2.64989898
114regulation of mitotic sister chromatid separation (GO:0010965)2.64989898
115regulation of mitotic sister chromatid segregation (GO:0033047)2.64989898
1163-UTR-mediated mRNA stabilization (GO:0070935)2.63588488
117somatic hypermutation of immunoglobulin genes (GO:0016446)2.63018931
118somatic diversification of immune receptors via somatic mutation (GO:0002566)2.63018931
119chromosome segregation (GO:0007059)2.62807322
120amino acid activation (GO:0043038)2.62133056
121tRNA aminoacylation (GO:0043039)2.62133056
122nucleobase-containing small molecule interconversion (GO:0015949)2.61399880
123positive regulation of SMAD protein import into nucleus (GO:0060391)2.61283134
124mRNA transport (GO:0051028)2.60802445
125DNA conformation change (GO:0071103)2.59866745
126regulation of nucleobase-containing compound transport (GO:0032239)2.59456701
127negative regulation of mRNA metabolic process (GO:1903312)2.57159188
128de novo protein folding (GO:0006458)2.54824830
129viral mRNA export from host cell nucleus (GO:0046784)2.54587648
130dosage compensation (GO:0007549)2.53986596
131positive regulation of keratinocyte differentiation (GO:0045618)2.53506836
132embryonic process involved in female pregnancy (GO:0060136)2.52841245
133de novo posttranslational protein folding (GO:0051084)2.52394169
134protein-DNA complex disassembly (GO:0032986)2.49420582
135nucleosome disassembly (GO:0006337)2.49420582
136RNA stabilization (GO:0043489)2.48711080
137mRNA stabilization (GO:0048255)2.48711080
138regulation of chromatin binding (GO:0035561)2.48468378
139mRNA export from nucleus (GO:0006406)2.48157091
140maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.47169794
141negative regulation of mRNA processing (GO:0050686)2.47162459
142histone H2B ubiquitination (GO:0033523)2.44633016
143positive regulation of cell cycle checkpoint (GO:1901978)2.44333242
144RNA export from nucleus (GO:0006405)2.43616271
145snRNA processing (GO:0016180)2.41924659
146peptidyl-lysine dimethylation (GO:0018027)2.41515704
147regulation of translational initiation (GO:0006446)2.40483787
148rRNA transcription (GO:0009303)2.40162739
149adherens junction assembly (GO:0034333)2.40065036
150histone H3-K9 demethylation (GO:0033169)2.39137177
151chromosome condensation (GO:0030261)2.38806976

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.97999093
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.45702592
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.60910269
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.39457365
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.24157780
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.22012459
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.82719900
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.67093836
9MYC_19030024_ChIP-ChIP_MESCs_Mouse2.43697179
10MYC_22102868_ChIP-Seq_BL_Human2.39282983
11AR_21909140_ChIP-Seq_LNCAP_Human2.28550145
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.19977292
13ZNF263_19887448_ChIP-Seq_K562_Human2.10670976
14NELFA_20434984_ChIP-Seq_ESCs_Mouse2.09005678
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.05513554
16ETS1_20019798_ChIP-Seq_JURKAT_Human1.99730345
17KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.97565349
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.93997508
19E2F1_21310950_ChIP-Seq_MCF-7_Human1.93240512
20XRN2_22483619_ChIP-Seq_HELA_Human1.92972454
21EST1_17652178_ChIP-ChIP_JURKAT_Human1.86757720
22PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.86181984
23MYCN_18555785_ChIP-Seq_MESCs_Mouse1.83327843
24TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.82724356
25CREB1_15753290_ChIP-ChIP_HEK293T_Human1.81478456
26POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.78532799
27TP63_17297297_ChIP-ChIP_HaCaT_Human1.77001237
28JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.72156551
29VDR_23849224_ChIP-Seq_CD4+_Human1.67278227
30GABP_17652178_ChIP-ChIP_JURKAT_Human1.66825151
31KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.66464815
32CIITA_25753668_ChIP-Seq_RAJI_Human1.66089828
33NANOG_18555785_ChIP-Seq_MESCs_Mouse1.65288367
34POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.61358386
35ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.60058298
36E2F1_18555785_ChIP-Seq_MESCs_Mouse1.57426546
37SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.56817911
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54550766
39MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.54525680
40GABP_19822575_ChIP-Seq_HepG2_Human1.50500976
41VDR_21846776_ChIP-Seq_THP-1_Human1.50263468
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.48413544
43CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.48231545
44CLOCK_20551151_ChIP-Seq_293T_Human1.47708081
45ZFX_18555785_ChIP-Seq_MESCs_Mouse1.47478678
46DCP1A_22483619_ChIP-Seq_HELA_Human1.47325449
47FOXP3_21729870_ChIP-Seq_TREG_Human1.45866302
48STAT3_1855785_ChIP-Seq_MESCs_Mouse1.45042679
49KDM5A_27292631_Chip-Seq_BREAST_Human1.44021591
50KLF4_18555785_ChIP-Seq_MESCs_Mouse1.43931690
51TFEB_21752829_ChIP-Seq_HELA_Human1.38645097
52TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.38359368
53HIF1A_21447827_ChIP-Seq_MCF-7_Human1.37189891
54HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.37109687
55DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.35884053
56TTF2_22483619_ChIP-Seq_HELA_Human1.34198134
57YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.29230633
58NOTCH1_21737748_ChIP-Seq_TLL_Human1.28184559
59SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.27896468
60E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.27066406
61RBPJ_22232070_ChIP-Seq_NCS_Mouse1.27029713
62SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.23371818
63CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.19474406
64CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.18542458
65TP63_19390658_ChIP-ChIP_HaCaT_Human1.17786192
66PKCTHETA_26484144_Chip-Seq_BREAST_Human1.17685321
67KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.14020264
68STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.13913443
69KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.13689065
70E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.12414921
71SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.11682213
72FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.10543110
73CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.10140637
74TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09207942
75HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.08768813
76ELK1_19687146_ChIP-ChIP_HELA_Human1.07450121
77MYB_21317192_ChIP-Seq_ERMYB_Mouse1.06847739
78SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.05954070
79TCF3_18692474_ChIP-Seq_MEFs_Mouse1.05032921
80NANOG_21062744_ChIP-ChIP_HESCs_Human1.04582602
81SALL1_21062744_ChIP-ChIP_HESCs_Human1.04390440
82BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.03727424
83ESR1_15608294_ChIP-ChIP_MCF-7_Human1.03110149
84CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.01602124
85POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.01470434
86SOX17_20123909_ChIP-Seq_XEN_Mouse1.01153787
87THAP11_20581084_ChIP-Seq_MESCs_Mouse1.01106083
88DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.00824804
89TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.00607003
90HOXB4_20404135_ChIP-ChIP_EML_Mouse1.00485482
91ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.99680370
92ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.98647407
93SPI1_23547873_ChIP-Seq_NB4_Human0.98481581
94ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.98212656
95UTX_26944678_Chip-Seq_JUKART_Human0.96905538
96RACK7_27058665_Chip-Seq_MCF-7_Human0.95337929
97KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.95182249
98ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.94866239
99NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.94806713
100ERG_20887958_ChIP-Seq_HPC-7_Mouse0.93990769
101SOX2_18555785_ChIP-Seq_MESCs_Mouse0.92378744
102EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.91690720
103PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.91671492
104NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.91648637
105TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91297471
106BRD4_27068464_Chip-Seq_AML-cells_Mouse0.91180572
107TCF7_22412390_ChIP-Seq_EML_Mouse0.90973146
108TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90888817
109GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.90707868
110MAF_26560356_Chip-Seq_TH1_Human0.90616424
111CHD1_26751641_Chip-Seq_LNCaP_Human0.89386146
112CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.89350022
113MYB_26560356_Chip-Seq_TH1_Human0.89317474
114YY1_21170310_ChIP-Seq_MESCs_Mouse0.89009219
115ATF3_27146783_Chip-Seq_COLON_Human0.88461084
116PADI4_21655091_ChIP-ChIP_MCF-7_Human0.87439622
117IRF8_21731497_ChIP-ChIP_J774_Mouse0.86762604
118NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.86732327
119ELF1_17652178_ChIP-ChIP_JURKAT_Human0.86517432
120FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.86272906
121ELK3_25401928_ChIP-Seq_HUVEC_Human0.86147887
122KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.85160397
123KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.84608455

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.16469639
2MP0010094_abnormal_chromosome_stability3.95879432
3MP0003111_abnormal_nucleus_morphology3.85916103
4MP0004957_abnormal_blastocyst_morpholog3.70305439
5MP0003077_abnormal_cell_cycle3.33745315
6MP0010352_gastrointestinal_tract_polyps3.22280611
7MP0008057_abnormal_DNA_replication2.88628659
8MP0010234_abnormal_vibrissa_follicle2.75628093
9MP0004233_abnormal_muscle_weight2.51140855
10MP0003705_abnormal_hypodermis_morpholog2.40818539
11MP0001730_embryonic_growth_arrest2.37842406
12MP0005451_abnormal_body_composition2.34365125
13MP0003123_paternal_imprinting2.32797488
14MP0010307_abnormal_tumor_latency2.32073780
15MP0000350_abnormal_cell_proliferation2.29637071
16MP0008260_abnormal_autophagy2.26206289
17MP0008007_abnormal_cellular_replicative2.25072676
18MP0005076_abnormal_cell_differentiation2.13560580
19MP0008932_abnormal_embryonic_tissue2.07050978
20MP0005623_abnormal_meninges_morphology2.03632515
21MP0008058_abnormal_DNA_repair2.00198840
22MP0005380_embryogenesis_phenotype1.90206644
23MP0001672_abnormal_embryogenesis/_devel1.90206644
24MP0001697_abnormal_embryo_size1.81065825
25MP0003984_embryonic_growth_retardation1.79843613
26MP0002396_abnormal_hematopoietic_system1.78350473
27MP0002088_abnormal_embryonic_growth/wei1.77243864
28MP0002009_preneoplasia1.69413851
29MP0008877_abnormal_DNA_methylation1.67230668
30MP0004197_abnormal_fetal_growth/weight/1.61743914
31MP0000490_abnormal_crypts_of1.60249622
32MP0003567_abnormal_fetal_cardiomyocyte1.60032023
33MP0002085_abnormal_embryonic_tissue1.59063652
34MP0002084_abnormal_developmental_patter1.58642638
35MP0000537_abnormal_urethra_morphology1.58298617
36MP0002086_abnormal_extraembryonic_tissu1.57685695
37MP0002080_prenatal_lethality1.56667010
38MP0006054_spinal_hemorrhage1.56514786
39MP0004808_abnormal_hematopoietic_stem1.55726089
40MP0009278_abnormal_bone_marrow1.55695859
41MP0003718_maternal_effect1.53767863
42MP0002796_impaired_skin_barrier1.50778914
43MP0005501_abnormal_skin_physiology1.49476733
44MP0001545_abnormal_hematopoietic_system1.45047851
45MP0005397_hematopoietic_system_phenotyp1.45047851
46MP0003941_abnormal_skin_development1.42961712
47MP0009840_abnormal_foam_cell1.40947948
48MP0002019_abnormal_tumor_incidence1.39641334
49MP0001915_intracranial_hemorrhage1.39333281
50MP0003303_peritoneal_inflammation1.38350943
51MP0003890_abnormal_embryonic-extraembry1.32122399
52MP0009333_abnormal_splenocyte_physiolog1.31820779
53MP0000313_abnormal_cell_death1.30389779
54MP0003566_abnormal_cell_adhesion1.30154117
55MP0000858_altered_metastatic_potential1.23150137
56MP0002398_abnormal_bone_marrow1.22222578
57MP0000733_abnormal_muscle_development1.20050936
58MP0003786_premature_aging1.19934057
59MP0003436_decreased_susceptibility_to1.17162936
60MP0005023_abnormal_wound_healing1.15657916
61MP0004272_abnormal_basement_membrane1.13216851
62MP0002098_abnormal_vibrissa_morphology1.12888173
63MP0003221_abnormal_cardiomyocyte_apopto1.12533206
64MP0001661_extended_life_span1.08162381
65MP0003121_genomic_imprinting1.07347677
66MP0000685_abnormal_immune_system1.07045806
67MP0010030_abnormal_orbit_morphology1.06773215
68MP0000689_abnormal_spleen_morphology1.06692577
69MP0002722_abnormal_immune_system1.06033235
70MP0002060_abnormal_skin_morphology1.05457594
71MP0002877_abnormal_melanocyte_morpholog1.04981924
72MP0004264_abnormal_extraembryonic_tissu1.04532868
73MP0000703_abnormal_thymus_morphology1.04211184
74MP0006035_abnormal_mitochondrial_morpho1.03363050
75MP0003453_abnormal_keratinocyte_physiol1.01654854
76MP0002697_abnormal_eye_size1.00834104
77MP0000747_muscle_weakness1.00776303
78MP0000579_abnormal_nail_morphology1.00448142
79MP0003315_abnormal_perineum_morphology0.99425073
80MP0001346_abnormal_lacrimal_gland0.99401810
81MP0005621_abnormal_cell_physiology0.98895157
82MP0000358_abnormal_cell_content/0.98041402
83MP0003806_abnormal_nucleotide_metabolis0.98021397
84MP0005058_abnormal_lysosome_morphology0.97249646
85MP0001293_anophthalmia0.96570403
86MP0005384_cellular_phenotype0.95827614
87MP0003448_altered_tumor_morphology0.95322525
88MP0002210_abnormal_sex_determination0.94306386
89MP0002006_tumorigenesis0.94110468
90MP0002269_muscular_atrophy0.93555515
91MP0001216_abnormal_epidermal_layer0.93218943
92MP0002429_abnormal_blood_cell0.92933845
93MP0001800_abnormal_humoral_immune0.92739644
94MP0009053_abnormal_anal_canal0.91000277
95MP0000627_abnormal_mammary_gland0.89041459
96MP0000716_abnormal_immune_system0.87781226
97MP0002653_abnormal_ependyma_morphology0.87748049
98MP0003115_abnormal_respiratory_system0.87165719
99MP0008438_abnormal_cutaneous_collagen0.87026835
100MP0000428_abnormal_craniofacial_morphol0.86729153
101MP0001145_abnormal_male_reproductive0.85966253
102MP0002452_abnormal_antigen_presenting0.85918614
103MP0001835_abnormal_antigen_presentation0.85137977
104MP0009672_abnormal_birth_weight0.84677804
105MP0000003_abnormal_adipose_tissue0.84098847
106MP0001929_abnormal_gametogenesis0.83522545
107MP0001727_abnormal_embryo_implantation0.83140055
108MP0004185_abnormal_adipocyte_glucose0.83113030
109MP0003763_abnormal_thymus_physiology0.81798899
110MP0000377_abnormal_hair_follicle0.79925539
111MP0003385_abnormal_body_wall0.79642314
112MP0002166_altered_tumor_susceptibility0.79635992
113MP0003656_abnormal_erythrocyte_physiolo0.79592000
114MP0000653_abnormal_sex_gland0.79510575
115MP0003935_abnormal_craniofacial_develop0.79206912
116MP0003191_abnormal_cellular_cholesterol0.79140255
117MP0002723_abnormal_immune_serum0.78748447
118MP0002089_abnormal_postnatal_growth/wei0.78644631
119MP0000467_abnormal_esophagus_morphology0.78277527
120MP0000750_abnormal_muscle_regeneration0.78102188
121MP0003943_abnormal_hepatobiliary_system0.77772921
122MP0001119_abnormal_female_reproductive0.77675336
123MP0001348_abnormal_lacrimal_gland0.77106841
124MP0003942_abnormal_urinary_system0.77074050
125MP0003091_abnormal_cell_migration0.76795425
126MP0005257_abnormal_intraocular_pressure0.76754628
127MP0001819_abnormal_immune_cell0.76557477
128MP0010630_abnormal_cardiac_muscle0.76465084
129MP0002420_abnormal_adaptive_immunity0.76172795
130MP0000477_abnormal_intestine_morphology0.75326915
131MP0009697_abnormal_copulation0.73819213
132MP0003119_abnormal_digestive_system0.73617085
133MP0002751_abnormal_autonomic_nervous0.73398872
134MP0001849_ear_inflammation0.73353982
135MP0004947_skin_inflammation0.73232572
136MP0000762_abnormal_tongue_morphology0.70588755
137MP0000759_abnormal_skeletal_muscle0.70482182
138MP0004782_abnormal_surfactant_physiolog0.69160429
139MP0009703_decreased_birth_body0.69080657
140MP0002405_respiratory_system_inflammati0.68407927
141MP0002092_abnormal_eye_morphology0.68372287
142MP0003937_abnormal_limbs/digits/tail_de0.67595996
143MP0005197_abnormal_uvea_morphology0.67261062
144MP0002111_abnormal_tail_morphology0.67124536
145MP0005000_abnormal_immune_tolerance0.65824087
146MP0010678_abnormal_skin_adnexa0.64827711
147MP0003699_abnormal_female_reproductive0.64219823

Predicted human phenotypes

RankGene SetZ-score
1Asymmetry of the thorax (HP:0001555)4.09783317
2Birth length less than 3rd percentile (HP:0003561)3.66257132
3Ependymoma (HP:0002888)3.37866900
4Breast hypoplasia (HP:0003187)3.30591472
5Microvesicular hepatic steatosis (HP:0001414)3.30576107
6Progressive external ophthalmoplegia (HP:0000590)3.24950827
7Abnormality of the anterior horn cell (HP:0006802)3.18273412
8Degeneration of anterior horn cells (HP:0002398)3.18273412
9Medulloblastoma (HP:0002885)3.18271385
10Agnosia (HP:0010524)3.17015877
11Colon cancer (HP:0003003)3.02791206
12Chromsome breakage (HP:0040012)2.99901143
13Rhabdomyosarcoma (HP:0002859)2.97748376
14Elevated erythrocyte sedimentation rate (HP:0003565)2.95697517
15Peritonitis (HP:0002586)2.93405208
16Progressive muscle weakness (HP:0003323)2.90508555
17Insidious onset (HP:0003587)2.86404887
18Termporal pattern (HP:0011008)2.86404887
19Selective tooth agenesis (HP:0001592)2.84396225
20Chromosomal breakage induced by crosslinking agents (HP:0003221)2.81386564
21Ragged-red muscle fibers (HP:0003200)2.77738015
22Facial hemangioma (HP:0000329)2.66581641
23Patellar aplasia (HP:0006443)2.64634391
24Cortical dysplasia (HP:0002539)2.63115109
25Microglossia (HP:0000171)2.62584768
26Abnormality of the labia minora (HP:0012880)2.58688826
27Micronodular cirrhosis (HP:0001413)2.58685249
28Septate vagina (HP:0001153)2.58380543
29Spinal cord lesions (HP:0100561)2.58235859
30Syringomyelia (HP:0003396)2.58235859
31Abnormality of the peritoneum (HP:0002585)2.57061824
32Short nail (HP:0001799)2.56094438
33Pelvic girdle muscle weakness (HP:0003749)2.50611039
34Deep philtrum (HP:0002002)2.48248078
35Aplasia/Hypoplasia of the patella (HP:0006498)2.45013247
36Hyperacusis (HP:0010780)2.44854336
37Deviation of the thumb (HP:0009603)2.42086856
38Carpal bone hypoplasia (HP:0001498)2.41239604
39Long palpebral fissure (HP:0000637)2.39306251
40Astrocytoma (HP:0009592)2.39015171
41Abnormality of the astrocytes (HP:0100707)2.39015171
42Proximal placement of thumb (HP:0009623)2.37350737
43Premature ovarian failure (HP:0008209)2.36864009
44Reticulocytopenia (HP:0001896)2.35100340
45Overlapping toe (HP:0001845)2.32257480
46Neoplasm of striated muscle (HP:0009728)2.31874356
47Prominent nose (HP:0000448)2.30700472
48Multiple enchondromatosis (HP:0005701)2.30351669
49Cerebral hypomyelination (HP:0006808)2.28241117
50Neoplasm of the pancreas (HP:0002894)2.26932493
51Impulsivity (HP:0100710)2.21203246
52Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.20569737
53Basal cell carcinoma (HP:0002671)2.20246600
54Cholecystitis (HP:0001082)2.20211451
55Abnormal gallbladder physiology (HP:0012438)2.20211451
56Malignant gastrointestinal tract tumors (HP:0006749)2.19005323
57Gastrointestinal carcinoma (HP:0002672)2.19005323
58Aplasia/Hypoplasia of the uvula (HP:0010293)2.17302212
59Abnormality of chromosome stability (HP:0003220)2.16802612
60Orthostatic hypotension (HP:0001278)2.14881314
61Abnormality of the umbilical cord (HP:0010881)2.14130119
62Abnormality of the distal phalanges of the toes (HP:0010182)2.11207260
63Biliary tract neoplasm (HP:0100574)2.10709965
64Shoulder girdle muscle weakness (HP:0003547)2.08175608
65Abnormality of glycolysis (HP:0004366)2.08061222
66Meckel diverticulum (HP:0002245)2.06745075
67Cafe-au-lait spot (HP:0000957)2.06626587
68Absent radius (HP:0003974)2.06395150
69High pitched voice (HP:0001620)2.06314033
70Amaurosis fugax (HP:0100576)2.04799367
71Increased nuchal translucency (HP:0010880)2.03482075
72Abnormality of the musculature of the pelvis (HP:0001469)2.01515879
73Abnormality of the hip-girdle musculature (HP:0001445)2.01515879
74Premature rupture of membranes (HP:0001788)2.00824791
75Myelodysplasia (HP:0002863)1.99712306
76Abnormality of the fetal cardiovascular system (HP:0010948)1.99095470
77Abnormal umbilical cord blood vessels (HP:0011403)1.99095470
78Single umbilical artery (HP:0001195)1.99095470
79Ectopic kidney (HP:0000086)1.98796046
80Abnormality of the ileum (HP:0001549)1.98190773
81Rough bone trabeculation (HP:0100670)1.97790871
82Increased density of long bones (HP:0006392)1.96490357
83Aplasia/hypoplasia of the humerus (HP:0006507)1.96464421
84Poikiloderma (HP:0001029)1.94540236
85Oral leukoplakia (HP:0002745)1.94435253
86Glioma (HP:0009733)1.92529150
87Neoplasm of the oral cavity (HP:0100649)1.92062606
88Atrophy/Degeneration involving motor neurons (HP:0007373)1.91557588
89Back pain (HP:0003418)1.91145834
90Sparse lateral eyebrow (HP:0005338)1.90993368
91Leiomyosarcoma (HP:0100243)1.90361940
92Uterine leiomyosarcoma (HP:0002891)1.90361940
93Genu recurvatum (HP:0002816)1.87632733
94High anterior hairline (HP:0009890)1.87593634
95Vertebral compression fractures (HP:0002953)1.87345308
96Insomnia (HP:0100785)1.86726557
97Ankle contracture (HP:0006466)1.86368929
98Abnormality of the fingertips (HP:0001211)1.86298095
99Absent forearm bone (HP:0003953)1.86103666
100Aplasia involving forearm bones (HP:0009822)1.86103666
101Spastic diplegia (HP:0001264)1.85093477
102Secondary amenorrhea (HP:0000869)1.84947365
103Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.84445439
104Uterine neoplasm (HP:0010784)1.84168092
105Natal tooth (HP:0000695)1.83012219
106Increased connective tissue (HP:0009025)1.81366102
107Advanced eruption of teeth (HP:0006288)1.81111666
108Abnormality of pyrimidine metabolism (HP:0004353)1.80932362
109Capillary hemangiomas (HP:0005306)1.80747939
110Ankyloglossia (HP:0010296)1.80621589
111Progressive hearing impairment (HP:0001730)1.79960877
112Sloping forehead (HP:0000340)1.79716817
113Thrombocytosis (HP:0001894)1.79450124
114Abnormalities of placenta or umbilical cord (HP:0001194)1.77937854
115Protrusio acetabuli (HP:0003179)1.77779182
116Trismus (HP:0000211)1.77337685
117Flat acetabular roof (HP:0003180)1.76561256
118Personality changes (HP:0000751)1.76097537
119Missing ribs (HP:0000921)1.75083809
120Increased serum pyruvate (HP:0003542)1.74551965
121Renal cell carcinoma (HP:0005584)1.73944555
122Ulnar bowing (HP:0003031)1.73289248
123Long eyelashes (HP:0000527)1.73015585
124Curly hair (HP:0002212)1.72978267
125Nephroblastoma (Wilms tumor) (HP:0002667)1.72851945
126Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.72764879
127Short 4th metacarpal (HP:0010044)1.72764879
128Abnormality of the calcaneus (HP:0008364)1.72722822
129Shallow orbits (HP:0000586)1.72552368
130Spinal muscular atrophy (HP:0007269)1.72386917
131Glossoptosis (HP:0000162)1.72384432
132Tracheoesophageal fistula (HP:0002575)1.72021803
133Short humerus (HP:0005792)1.71977489
134Cutaneous melanoma (HP:0012056)1.71302691
135Subacute progressive viral hepatitis (HP:0006572)1.70474756
136Recurrent viral infections (HP:0004429)1.70104600
137Small intestinal stenosis (HP:0012848)1.69632360
138Duodenal stenosis (HP:0100867)1.69632360
139Heterotopia (HP:0002282)1.69486102
140Osteolytic defects of the phalanges of the hand (HP:0009771)1.69396861
141Osteolytic defects of the hand bones (HP:0009699)1.69396861
142Absent thumb (HP:0009777)1.69126986
143Entropion (HP:0000621)1.67850359
144Angiofibromas (HP:0010615)1.67270027
145Adenoma sebaceum (HP:0009720)1.67270027
146Abnormal foot bone ossification (HP:0010675)1.67183950
147Slender long bone (HP:0003100)1.66248854
148Atresia of the external auditory canal (HP:0000413)1.65849134
149Squamous cell carcinoma (HP:0002860)1.65813395
150Upper motor neuron abnormality (HP:0002127)1.65529161
15111 pairs of ribs (HP:0000878)1.65070658
152Reticulocytosis (HP:0001923)1.63797656
153Abnormality of the preputium (HP:0100587)1.63698258
154Stenosis of the external auditory canal (HP:0000402)1.63634438
155Abnormality of oral frenula (HP:0000190)1.63280799
156Fatigue (HP:0012378)1.60991503
157Broad distal phalanx of finger (HP:0009836)1.59796761
158Embryonal renal neoplasm (HP:0011794)1.59546012
159Impaired proprioception (HP:0010831)1.57207059
160Hammertoe (HP:0001765)1.56581241
161Upper limb muscle weakness (HP:0003484)1.55198711
162Papillary thyroid carcinoma (HP:0002895)1.54195720
163Transitional cell carcinoma of the bladder (HP:0006740)1.53488852
164Abnormality of the phalanges of the hallux (HP:0010057)1.53433799
165Athetosis (HP:0002305)1.51565381
166Achilles tendon contracture (HP:0001771)1.49230253
167Hypopigmentation of the fundus (HP:0007894)1.48022688

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.70211990
2WEE13.25318663
3CDK123.10671783
4NEK23.09550758
5SMG12.86360122
6STK102.70791673
7BUB12.68577952
8MAP3K102.36125773
9RPS6KA42.32653088
10EIF2AK12.28006749
11TTK2.27603931
12PBK2.08709021
13CDK41.98717748
14ICK1.98056571
15EEF2K1.95991612
16NEK11.95744271
17MAP3K81.94635250
18DYRK31.91450466
19IRAK31.91024759
20NME21.82003999
21PKN21.79332572
22ACVR1B1.76180365
23PLK11.69857035
24SIK11.66936108
25SCYL21.64114823
26BRSK21.59447110
27PRPF4B1.52748600
28TRIB31.52579206
29TESK21.49259976
30STK31.48718854
31CHEK21.48599093
32TRIM281.45864634
33FLT31.45133618
34KSR21.44736504
35EPHA21.43637830
36SRPK11.39795631
37ATR1.37138819
38CDK71.36536171
39AURKB1.35818010
40TSSK61.34922646
41LRRK21.31691464
42PLK41.30656433
43PLK31.29068503
44LATS21.26920775
45PAK41.23575608
46RAF11.18535112
47RPS6KB21.14169103
48ALK1.13177638
49CHEK11.11980468
50CDK61.11363591
51PIM11.11272334
52MAP3K111.06942197
53TGFBR11.02808615
54MTOR1.01955077
55SIK31.01766576
56LATS11.01385499
57MOS1.00644201
58PASK0.99531528
59TLK10.99078364
60IRAK20.94592580
61MELK0.90808242
62MST1R0.89978684
63STK40.89701567
64NEK60.88608768
65YES10.85895469
66MAP4K10.84867147
67CDK20.84823357
68MKNK10.81527364
69FGFR40.80700352
70AURKA0.78858085
71JAK30.78687493
72NEK90.78391558
73NUAK10.77137544
74PTK60.76681069
75ATM0.74228008
76PDK20.73509022
77TTN0.70555983
78ZAP700.70254535
79BRSK10.69563120
80RPS6KB10.67624300
81MAP3K50.67415862
82EIF2AK30.66176601
83PTK20.65559363
84ERN10.64085518
85BRD40.63915052
86GRK60.60043301
87TAOK30.59968224
88TAOK20.59765570
89TESK10.58883459
90PDGFRA0.57891634
91ARAF0.56504213
92PAK10.55930784
93BCR0.55507470
94CDK10.55324286
95MET0.55200737
96BMX0.54898154
97CLK10.53231655
98MKNK20.52607659
99CSNK1A1L0.52348057
100CSNK1G30.52263026
101KSR10.52125873
102BRAF0.52121862
103EIF2AK20.52113957
104MAP2K70.51733506
105MAP3K90.51227057
106CDK90.49080613
107CHUK0.47888507
108CSF1R0.47233659
109PAK20.47150197
110TAF10.46788974
111VRK10.46711108
112CSNK2A20.46224246
113DYRK1B0.46194141
114ERBB40.45695951
115BLK0.44198754
116MAPK110.43939806
117CAMK1G0.42950986
118CDK180.41306555
119STK160.41229026
120RET0.39794380
121TYK20.39760168
122CAMK1D0.39731165
123PIM20.39238746
124CDK150.39179216
125CSNK1G10.38300818
126MAP3K140.37709872
127TYRO30.37352404
128AKT20.36998309
129PRKD30.36979326
130TBK10.36661086
131BTK0.35847401
132CDK140.35730153
133RPS6KA10.33499241
134RPS6KA50.33324822
135CSNK1E0.33144487
136MAP2K30.32982313
137TAOK10.32904497
138IKBKB0.32651903
139EPHB20.32325196
140RIPK10.29939667
141PRKDC0.29531966
142FGFR10.29043058

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.88348248
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.24259885
3Mismatch repair_Homo sapiens_hsa034303.17226797
4RNA transport_Homo sapiens_hsa030133.14314770
5Cell cycle_Homo sapiens_hsa041102.87123179
6One carbon pool by folate_Homo sapiens_hsa006702.61806655
7Spliceosome_Homo sapiens_hsa030402.56010242
8Base excision repair_Homo sapiens_hsa034102.45201448
9RNA polymerase_Homo sapiens_hsa030202.12599488
10Nucleotide excision repair_Homo sapiens_hsa034202.05588461
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.01454367
12Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.97902002
13Homologous recombination_Homo sapiens_hsa034401.96118356
14p53 signaling pathway_Homo sapiens_hsa041151.85959704
15Proteasome_Homo sapiens_hsa030501.76359143
16mRNA surveillance pathway_Homo sapiens_hsa030151.70234136
17Pyrimidine metabolism_Homo sapiens_hsa002401.68237797
18Basal transcription factors_Homo sapiens_hsa030221.52824022
19Fanconi anemia pathway_Homo sapiens_hsa034601.49851173
20Ribosome_Homo sapiens_hsa030101.48867938
21RNA degradation_Homo sapiens_hsa030181.46996119
22Non-homologous end-joining_Homo sapiens_hsa034501.42663574
23Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.42432696
24N-Glycan biosynthesis_Homo sapiens_hsa005101.39944576
25Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.38481225
26Antigen processing and presentation_Homo sapiens_hsa046121.37557307
27Endometrial cancer_Homo sapiens_hsa052131.34991813
28Epstein-Barr virus infection_Homo sapiens_hsa051691.34959300
29Herpes simplex infection_Homo sapiens_hsa051681.34412072
30Viral carcinogenesis_Homo sapiens_hsa052031.31128026
31Legionellosis_Homo sapiens_hsa051341.29908726
32Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.22520470
33Small cell lung cancer_Homo sapiens_hsa052221.18548454
34MicroRNAs in cancer_Homo sapiens_hsa052061.18462912
35Sulfur relay system_Homo sapiens_hsa041221.14920473
36Oocyte meiosis_Homo sapiens_hsa041141.12632734
37Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.10602794
38Systemic lupus erythematosus_Homo sapiens_hsa053221.08388846
39Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.05730252
40Apoptosis_Homo sapiens_hsa042101.04939220
41NF-kappa B signaling pathway_Homo sapiens_hsa040641.04078375
42Chronic myeloid leukemia_Homo sapiens_hsa052201.02911664
43Steroid biosynthesis_Homo sapiens_hsa001001.00992209
44HTLV-I infection_Homo sapiens_hsa051661.00080865
45Alcoholism_Homo sapiens_hsa050340.98514075
46Fructose and mannose metabolism_Homo sapiens_hsa000510.98195473
47Selenocompound metabolism_Homo sapiens_hsa004500.97332967
48Folate biosynthesis_Homo sapiens_hsa007900.95735105
49Pentose phosphate pathway_Homo sapiens_hsa000300.93956912
50mTOR signaling pathway_Homo sapiens_hsa041500.93036981
51Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.92834771
52Vibrio cholerae infection_Homo sapiens_hsa051100.89528415
53Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.89410587
54Thyroid cancer_Homo sapiens_hsa052160.89109547
55Colorectal cancer_Homo sapiens_hsa052100.88854841
56Biosynthesis of amino acids_Homo sapiens_hsa012300.88483917
57Leishmaniasis_Homo sapiens_hsa051400.87935869
58Hepatitis B_Homo sapiens_hsa051610.86959202
59NOD-like receptor signaling pathway_Homo sapiens_hsa046210.84963318
60ErbB signaling pathway_Homo sapiens_hsa040120.84245367
61Cysteine and methionine metabolism_Homo sapiens_hsa002700.83056404
62Shigellosis_Homo sapiens_hsa051310.80055680
63Viral myocarditis_Homo sapiens_hsa054160.80019068
64Insulin signaling pathway_Homo sapiens_hsa049100.79821407
65Longevity regulating pathway - mammal_Homo sapiens_hsa042110.77760552
66Glycosaminoglycan degradation_Homo sapiens_hsa005310.77062495
67Galactose metabolism_Homo sapiens_hsa000520.76503668
68Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.75555638
69Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.75381768
70Glioma_Homo sapiens_hsa052140.74295741
71Measles_Homo sapiens_hsa051620.74135856
72Vitamin B6 metabolism_Homo sapiens_hsa007500.73538342
73AMPK signaling pathway_Homo sapiens_hsa041520.72424655
74Pancreatic cancer_Homo sapiens_hsa052120.72377272
75Notch signaling pathway_Homo sapiens_hsa043300.70942134
76Influenza A_Homo sapiens_hsa051640.70861650
77Inositol phosphate metabolism_Homo sapiens_hsa005620.70637971
78Hippo signaling pathway_Homo sapiens_hsa043900.69820588
79Acute myeloid leukemia_Homo sapiens_hsa052210.69428204
80Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67737177
81Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.67686823
82B cell receptor signaling pathway_Homo sapiens_hsa046620.67527129
83Bladder cancer_Homo sapiens_hsa052190.66440214
84Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.65388969
85TNF signaling pathway_Homo sapiens_hsa046680.64938362
86Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.64887654
87Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.64856287
88Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.64220604
89Other glycan degradation_Homo sapiens_hsa005110.64202977
90Drug metabolism - other enzymes_Homo sapiens_hsa009830.62619683
91TGF-beta signaling pathway_Homo sapiens_hsa043500.61735322
92Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.61629759
93Adherens junction_Homo sapiens_hsa045200.60222607
94Hepatitis C_Homo sapiens_hsa051600.60109142
95Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.58850188
96Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.58294869
97RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.56537513
98HIF-1 signaling pathway_Homo sapiens_hsa040660.55932695
99Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.55175482
100Central carbon metabolism in cancer_Homo sapiens_hsa052300.54302980
101Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54179524
102Purine metabolism_Homo sapiens_hsa002300.53069909
103Proteoglycans in cancer_Homo sapiens_hsa052050.52965273
104Prolactin signaling pathway_Homo sapiens_hsa049170.52870940
105Osteoclast differentiation_Homo sapiens_hsa043800.52656848
106Fatty acid elongation_Homo sapiens_hsa000620.52182622
107Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.51681259
108Toxoplasmosis_Homo sapiens_hsa051450.51654152
109Melanoma_Homo sapiens_hsa052180.49134093
110Toll-like receptor signaling pathway_Homo sapiens_hsa046200.48745827
111Prostate cancer_Homo sapiens_hsa052150.48153091
112Neurotrophin signaling pathway_Homo sapiens_hsa047220.48104073
113AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.46564314
114Non-small cell lung cancer_Homo sapiens_hsa052230.46368565
115Leukocyte transendothelial migration_Homo sapiens_hsa046700.45540230
116Sphingolipid metabolism_Homo sapiens_hsa006000.44623274
117Primary immunodeficiency_Homo sapiens_hsa053400.43787882
118VEGF signaling pathway_Homo sapiens_hsa043700.41713477
119Focal adhesion_Homo sapiens_hsa045100.41467289
120Pathways in cancer_Homo sapiens_hsa052000.41315090
121Sphingolipid signaling pathway_Homo sapiens_hsa040710.40254655
122Tuberculosis_Homo sapiens_hsa051520.39680371
123Lysine degradation_Homo sapiens_hsa003100.38438320
124FoxO signaling pathway_Homo sapiens_hsa040680.36350553
125Renal cell carcinoma_Homo sapiens_hsa052110.36133727
126Intestinal immune network for IgA production_Homo sapiens_hsa046720.35200048
1272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.34068675
128Salmonella infection_Homo sapiens_hsa051320.33482488
129Jak-STAT signaling pathway_Homo sapiens_hsa046300.32901233
130Graft-versus-host disease_Homo sapiens_hsa053320.32625632
131Thyroid hormone signaling pathway_Homo sapiens_hsa049190.32188508
132Carbon metabolism_Homo sapiens_hsa012000.31025895

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