SMG9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a regulatory subunit of the SMG1 complex, which plays a critical role in nonsense-mediated mRNA decay (NMD). Binding of the encoded protein to the SMG1 complex kinase scaffold protein results in the inhibition of its kinase activity. Mutations in this gene cause a multiple congenital anomaly syndrome in human patients, characterized by brain malformation, congenital heart disease and other features. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)8.79241708
2pore complex assembly (GO:0046931)7.28681093
3nuclear pore organization (GO:0006999)7.14815699
4startle response (GO:0001964)6.26455473
5synapsis (GO:0007129)6.25953566
6axonemal dynein complex assembly (GO:0070286)5.83111957
7cellular protein complex localization (GO:0034629)5.72623863
8cilium or flagellum-dependent cell motility (GO:0001539)5.33010943
9protein localization to microtubule (GO:0035372)4.79071046
10regulation of nuclear cell cycle DNA replication (GO:0033262)4.77793713
11positive regulation of microtubule polymerization (GO:0031116)4.76962585
12negative regulation of axon guidance (GO:1902668)4.63953133
13protein complex localization (GO:0031503)4.51285187
14positive regulation of heat generation (GO:0031652)4.46585288
15regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)4.46066731
16kynurenine metabolic process (GO:0070189)4.34563972
17positive regulation of gamma-delta T cell activation (GO:0046645)4.31121515
18antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.20974761
19cytoplasmic microtubule organization (GO:0031122)4.17039029
20RNA localization (GO:0006403)4.16289729
21positive regulation of membrane protein ectodomain proteolysis (GO:0051044)4.15765906
22epithelial cilium movement (GO:0003351)4.15747423
23localization within membrane (GO:0051668)4.07427862
24positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)4.04897981
25positive regulation of pseudopodium assembly (GO:0031274)3.94765503
26cellular response to ATP (GO:0071318)3.93305654
27tryptophan catabolic process (GO:0006569)3.92229082
28indole-containing compound catabolic process (GO:0042436)3.92229082
29indolalkylamine catabolic process (GO:0046218)3.92229082
30amine catabolic process (GO:0009310)3.87524903
31cellular biogenic amine catabolic process (GO:0042402)3.87524903
32regulation of vitamin D biosynthetic process (GO:0060556)3.85485629
33positive regulation of ERBB signaling pathway (GO:1901186)3.83534066
34regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)3.82402622
35regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.77628379
36positive regulation of lymphocyte apoptotic process (GO:0070230)3.74746204
37seminiferous tubule development (GO:0072520)3.69963871
38interkinetic nuclear migration (GO:0022027)3.69008863
39regulation of pseudopodium assembly (GO:0031272)3.63604469
40epithelial cell differentiation involved in kidney development (GO:0035850)3.62353880
41monocyte chemotaxis (GO:0002548)3.54741961
42positive regulation of protein deacetylation (GO:0090312)3.53074908
43regulation of glomerular filtration (GO:0003093)3.51572780
44mannose metabolic process (GO:0006013)3.45881891
45photoreceptor cell differentiation (GO:0046530)3.43582094
46eye photoreceptor cell differentiation (GO:0001754)3.43582094
47NAD biosynthetic process (GO:0009435)3.42357119
48chromosome organization involved in meiosis (GO:0070192)3.42290216
49negative regulation of interleukin-12 production (GO:0032695)3.41970827
50positive regulation of histone deacetylation (GO:0031065)3.38328596
51dendritic cell chemotaxis (GO:0002407)3.36783804
52interferon-gamma production (GO:0032609)3.35509777
53positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.34438799
54regulation of B cell receptor signaling pathway (GO:0050855)3.32982486
55sequestering of actin monomers (GO:0042989)3.31519491
56acrosome reaction (GO:0007340)3.30382607
57histone H3-K4 trimethylation (GO:0080182)3.27332929
58negative regulation of cell killing (GO:0031342)3.25593225
59negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.25593225
60positive regulation of microtubule polymerization or depolymerization (GO:0031112)3.22105376
61endosome to melanosome transport (GO:0035646)3.21808098
62endosome to pigment granule transport (GO:0043485)3.21808098
63snRNA transcription (GO:0009301)3.20888348
64sperm motility (GO:0030317)3.19338683
65leukocyte aggregation (GO:0070486)3.16474689
66positive regulation by symbiont of host defense response (GO:0052509)3.13421363
67modulation by symbiont of host defense response (GO:0052031)3.13421363
68modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.13421363
69modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.13421363
70positive regulation by organism of defense response of other organism involved in symbiotic interact3.13421363
71modulation by symbiont of host immune response (GO:0052553)3.13421363
72regulation of heat generation (GO:0031650)3.13192714
73cellular response to exogenous dsRNA (GO:0071360)3.11252343
74opioid receptor signaling pathway (GO:0038003)3.10604507
75positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.08612240
76histone H3-K9 methylation (GO:0051567)3.06193063
77acrosome assembly (GO:0001675)3.05868435
78glomerulus development (GO:0032835)3.05426600
79lipopolysaccharide-mediated signaling pathway (GO:0031663)3.03883237
80regulation of interferon-gamma biosynthetic process (GO:0045072)3.02939586
81modulation by symbiont of host cellular process (GO:0044068)3.02416856
82negative regulation of telomere maintenance (GO:0032205)3.01617067
83histone H3-K9 modification (GO:0061647)3.01487276
84piRNA metabolic process (GO:0034587)2.99712673
85microtubule depolymerization (GO:0007019)2.98254724
86NIK/NF-kappaB signaling (GO:0038061)2.98194676
87histone H2A acetylation (GO:0043968)2.98064667
88multicellular organism reproduction (GO:0032504)2.96027484
89regulation of chronic inflammatory response (GO:0002676)2.94330308
90positive thymic T cell selection (GO:0045059)2.94312341
91antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.93826312
92antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.93826312
93negative regulation of heart rate (GO:0010459)2.92997653
94modulation by virus of host process (GO:0019054)2.92699236
95positive regulation of CREB transcription factor activity (GO:0032793)2.91814934
96regulation of membrane protein ectodomain proteolysis (GO:0051043)2.90864419
97regulation of fever generation (GO:0031620)2.90466249
98neutrophil activation (GO:0042119)2.90352551
99negative regulation of defense response to virus (GO:0050687)2.89841099
100interleukin-1-mediated signaling pathway (GO:0070498)2.88534070
101tryptophan metabolic process (GO:0006568)2.87226180
102response to misfolded protein (GO:0051788)2.86434712
103cell-cell junction maintenance (GO:0045217)2.84825568
104regulation of sensory perception of pain (GO:0051930)2.83918064
105regulation of sensory perception (GO:0051931)2.83918064
106regulation of gamma-delta T cell activation (GO:0046643)2.83852565
107positive T cell selection (GO:0043368)2.82784221
108regulation of histone deacetylation (GO:0031063)2.82404874
109negative regulation of glycogen metabolic process (GO:0070874)2.81631863
110indolalkylamine metabolic process (GO:0006586)2.80951481
111regulation of helicase activity (GO:0051095)2.80790895
112cilium movement (GO:0003341)2.80260222
113regulation of axon guidance (GO:1902667)2.80042894
114ionotropic glutamate receptor signaling pathway (GO:0035235)2.78504715
115germinal center formation (GO:0002467)2.75721698
116cellular response to nicotine (GO:0071316)2.75478873
117renal system process involved in regulation of blood volume (GO:0001977)2.75411781
118cell-cell recognition (GO:0009988)2.75085951
119positive regulation of DNA-dependent DNA replication (GO:2000105)2.74592713
120response to acidic pH (GO:0010447)2.74550878
121antigen processing and presentation of endogenous antigen (GO:0019883)2.73215742
122sperm-egg recognition (GO:0035036)2.72127649
123positive regulation of defense response to virus by host (GO:0002230)2.72077357
124meiotic chromosome segregation (GO:0045132)2.72070543
125CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.71870163
126regulation of cytokine secretion involved in immune response (GO:0002739)2.71783021
127positive regulation of chemokine biosynthetic process (GO:0045080)2.70597695
128regulation of defense response to virus by host (GO:0050691)2.69679467
129positive regulation of T cell apoptotic process (GO:0070234)2.69009036
130response to ATP (GO:0033198)2.68854528
131nicotinamide nucleotide biosynthetic process (GO:0019359)2.68754569
132pyridine nucleotide biosynthetic process (GO:0019363)2.68754569
133regulation of telomere maintenance (GO:0032204)2.68509053
134regulation of histone phosphorylation (GO:0033127)2.68032679
135motile cilium assembly (GO:0044458)2.67022595
136phosphatidylglycerol biosynthetic process (GO:0006655)2.66896592
137intracellular estrogen receptor signaling pathway (GO:0030520)2.63251492
138barbed-end actin filament capping (GO:0051016)2.62999293
139DNA double-strand break processing (GO:0000729)2.62255163
140G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.61581278
141positive regulation of neurotransmitter secretion (GO:0001956)2.61549676
142response to peptidoglycan (GO:0032494)2.61456575
143cellular response to virus (GO:0098586)2.60724077
144negative regulation of macroautophagy (GO:0016242)2.59813653
145T cell selection (GO:0045058)2.58641325
146granulocyte activation (GO:0036230)2.57464749
147protein localization to microtubule cytoskeleton (GO:0072698)2.57263446
148replication fork processing (GO:0031297)2.57194838
149ganglion development (GO:0061548)2.57049183
150positive regulation of protein kinase C signaling (GO:0090037)2.56094595
151dendritic cell migration (GO:0036336)2.56094409
152thymic T cell selection (GO:0045061)2.55985476
153negative regulation of skeletal muscle tissue development (GO:0048642)2.55595148
154negative regulation of phagocytosis (GO:0050765)2.55079326
155T cell lineage commitment (GO:0002360)2.55058713
156stem cell division (GO:0017145)2.54759178
157positive regulation of isotype switching (GO:0045830)2.54441375
158regulation of monocyte differentiation (GO:0045655)2.53762095
159regulation of necroptotic process (GO:0060544)2.53660064
160protein polyglutamylation (GO:0018095)2.52392513
161response to nerve growth factor (GO:1990089)2.51848286
162cellular response to nerve growth factor stimulus (GO:1990090)2.51848286
163negative regulation of tumor necrosis factor production (GO:0032720)2.51156496
164negative regulation of erythrocyte differentiation (GO:0045647)2.50685297
165tRNA methylation (GO:0030488)2.50450730
166DNA methylation involved in gamete generation (GO:0043046)2.50112705
167positive regulation of prostaglandin secretion (GO:0032308)2.49535931
168misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.49368446
169negative regulation of nitric oxide biosynthetic process (GO:0045019)2.49070900
170negative regulation of cAMP-mediated signaling (GO:0043951)2.48869211
171chromosome condensation (GO:0030261)2.48297605
172regulation of histone H3-K27 methylation (GO:0061085)2.45012319
173regulation of apoptotic process involved in morphogenesis (GO:1902337)2.44555149
174pyridine-containing compound biosynthetic process (GO:0072525)2.44494125
175ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.43210488
176regulation of chromatin binding (GO:0035561)2.42927005
177regulation of T-helper 1 cell differentiation (GO:0045625)2.42520410
178sphingosine metabolic process (GO:0006670)2.41140799
179regulation of type I interferon-mediated signaling pathway (GO:0060338)2.40765569
180UV protection (GO:0009650)2.40134926
181cellular response to arsenic-containing substance (GO:0071243)2.39854898
182spliceosomal tri-snRNP complex assembly (GO:0000244)2.38653232
183negative regulation of systemic arterial blood pressure (GO:0003085)2.38150591
184negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.37806582
185membrane protein intracellular domain proteolysis (GO:0031293)2.37712227
186positive regulation of neurotransmitter transport (GO:0051590)2.36932552
187activation of MAPKKK activity (GO:0000185)2.36660302
188DNA packaging (GO:0006323)2.36629467
189regulation of interferon-alpha production (GO:0032647)2.33731685
190positive regulation of triglyceride biosynthetic process (GO:0010867)2.32448449
191protein insertion into membrane (GO:0051205)2.31195238
192T-helper 1 type immune response (GO:0042088)2.30696310
193amino sugar catabolic process (GO:0046348)2.30185526

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.22650575
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.61552971
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.27207606
4EZH2_22144423_ChIP-Seq_EOC_Human3.85159924
5CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons3.58248122
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.35166316
7IRF8_22096565_ChIP-ChIP_GC-B_Human3.27689047
8LXR_22292898_ChIP-Seq_THP-1_Human2.75210938
9STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.67131774
10CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.64157776
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.41047186
12SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.35961022
13SCL_19346495_ChIP-Seq_HPC-7_Human2.34364862
14IRF8_27001747_Chip-Seq_BMDM_Mouse2.32941468
15MYB_26560356_Chip-Seq_TH1_Human2.28961972
16P68_20966046_ChIP-Seq_HELA_Human2.25837012
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.24854390
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.18051178
19RBPJ_22232070_ChIP-Seq_NCS_Mouse2.16377403
20RUNX_20019798_ChIP-Seq_JUKART_Human2.14782352
21TCF7_22412390_ChIP-Seq_EML_Mouse2.13050700
22PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse2.12856435
23VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.10540793
24RCOR2_21632747_ChIP-Seq_MESCs_Mouse2.04599044
25GATA1_26923725_Chip-Seq_HPCs_Mouse2.04536925
26ELK3_25401928_ChIP-Seq_HUVEC_Human2.04495491
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.04213553
28RUNX1_17652178_ChIP-ChIP_JURKAT_Human2.00418438
29DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.00351330
30RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.00129078
31MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.99770138
32BCOR_27268052_Chip-Seq_Bcells_Human1.94258447
33SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.90487047
34FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.89180417
35MYB_26560356_Chip-Seq_TH2_Human1.86349385
36CIITA_25753668_ChIP-Seq_RAJI_Human1.83337886
37BRD4_27068464_Chip-Seq_AML-cells_Mouse1.81385303
38MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.80156295
39STAT4_19710469_ChIP-ChIP_TH1__Mouse1.80118093
40DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.79193232
41MYB_21317192_ChIP-Seq_ERMYB_Mouse1.79073378
42FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.78690321
43PHF8_20622854_ChIP-Seq_HELA_Human1.75702663
44MYC_22102868_ChIP-Seq_BL_Human1.75397506
45YY1_22570637_ChIP-Seq_MALME-3M_Human1.74617978
46BP1_19119308_ChIP-ChIP_Hs578T_Human1.73012972
47ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.69753753
48EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.67809537
49SA1_27219007_Chip-Seq_ERYTHROID_Human1.65164468
50NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.64747897
51EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.62214682
52TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61603849
53E2F1_20622854_ChIP-Seq_HELA_Human1.61120989
54RUNX1_22412390_ChIP-Seq_EML_Mouse1.59879749
55SMC4_20622854_ChIP-Seq_HELA_Human1.59427622
56LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.59130011
57FOXM1_23109430_ChIP-Seq_U2OS_Human1.59009338
58EGR1_19374776_ChIP-ChIP_THP-1_Human1.58987016
59TP53_22127205_ChIP-Seq_IMR90_Human1.57745514
60LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.57720627
61KDM5A_27292631_Chip-Seq_BREAST_Human1.56470594
62MAF_26560356_Chip-Seq_TH2_Human1.55928270
63GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.55412265
64STAT1_20625510_ChIP-Seq_HELA_Human1.54631038
65THAP11_20581084_ChIP-Seq_MESCs_Mouse1.53178304
66KDM2B_26808549_Chip-Seq_K562_Human1.52567464
67JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.52236628
68SPI1_23127762_ChIP-Seq_K562_Human1.51452357
69CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.50118226
70SPI1_23547873_ChIP-Seq_NB4_Human1.49289161
71NOTCH1_21737748_ChIP-Seq_TLL_Human1.49172475
72CTCF_27219007_Chip-Seq_ERYTHROID_Human1.48488054
73TP63_19390658_ChIP-ChIP_HaCaT_Human1.47548534
74UTX_26944678_Chip-Seq_JUKART_Human1.47130602
75TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.45888655
76CTCF_20526341_ChIP-Seq_ESCs_Human1.44145300
77Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.43975595
78PU.1_20513432_ChIP-Seq_Bcells_Mouse1.43761610
79HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.43035403
80SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.42812905
81ETS1_20019798_ChIP-Seq_JURKAT_Human1.41932581
82FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.41370788
83E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.39177111
84RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.38858245
85CTCF_27219007_Chip-Seq_Bcells_Human1.37708495
86PKCTHETA_26484144_Chip-Seq_BREAST_Human1.37264991
87RACK7_27058665_Chip-Seq_MCF-7_Human1.37211981
88NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.33196689
89SRY_22984422_ChIP-ChIP_TESTIS_Rat1.32499931
90SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.30697678
91KDM2B_26808549_Chip-Seq_JURKAT_Human1.29992009
92GABP_19822575_ChIP-Seq_HepG2_Human1.28533145
93STAT6_21828071_ChIP-Seq_BEAS2B_Human1.27862658
94CREB1_26743006_Chip-Seq_LNCaP_Human1.27149966
95CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.26909510
96NCOR1_26117541_ChIP-Seq_K562_Human1.26602233
97CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.25637329
98TP63_22573176_ChIP-Seq_HFKS_Human1.25195815
99SA1_27219007_Chip-Seq_Bcells_Human1.23732325
100E2F7_22180533_ChIP-Seq_HELA_Human1.23429000
101FOXP1_21924763_ChIP-Seq_HESCs_Human1.23333353
102CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.22312829
103CTCF_21964334_ChIP-Seq_BJAB-B_Human1.19929289
104CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.19629497
105DNAJC2_21179169_ChIP-ChIP_NT2_Human1.18201211
106THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.17997913
107BCL6_27268052_Chip-Seq_Bcells_Human1.16995194
108UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.15815258
109OCT4_19829295_ChIP-Seq_ESCs_Human1.15778158
110GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.15614238
111CTCF_26484167_Chip-Seq_Bcells_Mouse1.15214807
112SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.14845322
113ERA_21632823_ChIP-Seq_H3396_Human1.14306355
114NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.13063663
115PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13010510
116RARA_24833708_ChIP-Seq_LIVER_Mouse1.12912412
117RARB_24833708_ChIP-Seq_LIVER_Mouse1.12814465
118MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.12735000
119VDR_21846776_ChIP-Seq_THP-1_Human1.12419166
120SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.11870627
121ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.11691012
122RAC3_21632823_ChIP-Seq_H3396_Human1.11433508
123ELF1_20517297_ChIP-Seq_JURKAT_Human1.10825942
124MAF_26560356_Chip-Seq_TH1_Human1.10748944
125HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.10342928
126P300_27268052_Chip-Seq_Bcells_Human1.09477859
127CTCF_18555785_ChIP-Seq_MESCs_Mouse1.06406114
128VDR_24763502_ChIP-Seq_THP-1_Human1.06342664
129VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.05814918
130P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05629842
131SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.05265624
132TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.05183699
133SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04917716
134GATA1_19941827_ChIP-Seq_MEL_Mouse1.02067285
135FLI1_27457419_Chip-Seq_LIVER_Mouse1.02031514
136PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01578130
137KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.01212706
138PU_27001747_Chip-Seq_BMDM_Mouse1.00643253
139TET1_21451524_ChIP-Seq_MESCs_Mouse0.99307896
140RUNX1_26923725_Chip-Seq_HPCs_Mouse0.98831404
141CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98761529
142E2F4_17652178_ChIP-ChIP_JURKAT_Human0.98317571
143GATA3_26560356_Chip-Seq_TH2_Human0.97447178
144KDM2B_26808549_Chip-Seq_DND41_Human0.96874135
145EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.95728187
146IRF1_19129219_ChIP-ChIP_H3396_Human0.95348279
147GATA2_22383799_ChIP-Seq_G1ME_Mouse0.94976407
148PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94066008
149FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92922809
150REST_21632747_ChIP-Seq_MESCs_Mouse0.91770480
151PCGF2_27294783_Chip-Seq_ESCs_Mouse0.90520003
152BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.90382973
153RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86429783
154GATA1_22383799_ChIP-Seq_G1ME_Mouse0.86326363
155KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.86177109
156IKZF1_21737484_ChIP-ChIP_HCT116_Human0.84047121
157NFE2_27457419_Chip-Seq_LIVER_Mouse0.82416161
158ZFP281_27345836_Chip-Seq_ESCs_Mouse0.79281869
159FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79213121
160CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.78841526
161KDM2B_26808549_Chip-Seq_SUP-B15_Human0.77023853
162WDR5_24793694_ChIP-Seq_LNCAP_Human0.76295675
163SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.75698522

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation5.99004673
2MP0002396_abnormal_hematopoietic_system3.77797049
3MP0000465_gastrointestinal_hemorrhage3.58749427
4MP0005058_abnormal_lysosome_morphology3.29343543
5MP0003787_abnormal_imprinting3.25374229
6MP0005410_abnormal_fertilization3.21189103
7MP0005248_abnormal_Harderian_gland3.20791555
8MP0010352_gastrointestinal_tract_polyps3.01145937
9MP0010386_abnormal_urinary_bladder2.95129981
10MP0001835_abnormal_antigen_presentation2.83285776
11MP0005671_abnormal_response_to2.48574993
12MP0009840_abnormal_foam_cell2.47116573
13MP0009278_abnormal_bone_marrow2.35963098
14MP0003436_decreased_susceptibility_to2.24652616
15MP0002909_abnormal_adrenal_gland2.20425141
16MP0003763_abnormal_thymus_physiology2.19556368
17MP0008057_abnormal_DNA_replication2.05628464
18MP0008058_abnormal_DNA_repair2.03940756
19MP0009764_decreased_sensitivity_to1.94146488
20MP0002127_abnormal_cardiovascular_syste1.85428160
21MP0005000_abnormal_immune_tolerance1.80457191
22MP0005451_abnormal_body_composition1.79719014
23MP0001800_abnormal_humoral_immune1.79378970
24MP0001790_abnormal_immune_system1.78702740
25MP0005387_immune_system_phenotype1.78702740
26MP0003111_abnormal_nucleus_morphology1.76524514
27MP0002095_abnormal_skin_pigmentation1.76256275
28MP0001986_abnormal_taste_sensitivity1.75876714
29MP0001545_abnormal_hematopoietic_system1.68188276
30MP0005397_hematopoietic_system_phenotyp1.68188276
31MP0009046_muscle_twitch1.67486660
32MP0002254_reproductive_system_inflammat1.67312082
33MP0002452_abnormal_antigen_presenting1.65279189
34MP0000015_abnormal_ear_pigmentation1.64998996
35MP0002398_abnormal_bone_marrow1.64799851
36MP0005025_abnormal_response_to1.64326351
37MP0009785_altered_susceptibility_to1.64280764
38MP0000685_abnormal_immune_system1.63739761
39MP0002420_abnormal_adaptive_immunity1.61318624
40MP0001819_abnormal_immune_cell1.61132840
41MP0001968_abnormal_touch/_nociception1.60234993
42MP0000569_abnormal_digit_pigmentation1.58724580
43MP0002419_abnormal_innate_immunity1.58424654
44MP0001919_abnormal_reproductive_system1.57387927
45MP0005174_abnormal_tail_pigmentation1.56964889
46MP0002405_respiratory_system_inflammati1.56201847
47MP0002723_abnormal_immune_serum1.55405544
48MP0010307_abnormal_tumor_latency1.54379354
49MP0003698_abnormal_male_reproductive1.53901046
50MP0001873_stomach_inflammation1.53716565
51MP0000703_abnormal_thymus_morphology1.50654555
52MP0002733_abnormal_thermal_nociception1.48116430
53MP0002653_abnormal_ependyma_morphology1.46817336
54MP0004133_heterotaxia1.45934462
55MP0002148_abnormal_hypersensitivity_rea1.45876226
56MP0000490_abnormal_crypts_of1.43721937
57MP0005171_absent_coat_pigmentation1.42931365
58MP0005310_abnormal_salivary_gland1.42435446
59MP0005464_abnormal_platelet_physiology1.42363816
60MP0003878_abnormal_ear_physiology1.41187783
61MP0005377_hearing/vestibular/ear_phenot1.41187783
62MP0004742_abnormal_vestibular_system1.40871409
63MP0000716_abnormal_immune_system1.40100087
64MP0003786_premature_aging1.38664385
65MP0004134_abnormal_chest_morphology1.34290353
66MP0001929_abnormal_gametogenesis1.32042958
67MP0002064_seizures1.29037203
68MP0000678_abnormal_parathyroid_gland1.28614864
69MP0001501_abnormal_sleep_pattern1.24565198
70MP0000689_abnormal_spleen_morphology1.23658808
71MP0006082_CNS_inflammation1.23613508
72MP0005076_abnormal_cell_differentiation1.21578273
73MP0002722_abnormal_immune_system1.20865435
74MP0008877_abnormal_DNA_methylation1.19162669
75MP0001970_abnormal_pain_threshold1.18180997
76MP0004510_myositis1.18116665
77MP0000371_diluted_coat_color1.16429490
78MP0002429_abnormal_blood_cell1.13524279
79MP0003453_abnormal_keratinocyte_physiol1.13138447
80MP0002138_abnormal_hepatobiliary_system1.12139229
81MP0010094_abnormal_chromosome_stability1.10772078
82MP0008961_abnormal_basal_metabolism1.08357920
83MP0006292_abnormal_olfactory_placode1.08158463
84MP0003448_altered_tumor_morphology1.08013797
85MP0003646_muscle_fatigue1.07105371
86MP0009745_abnormal_behavioral_response1.05912185
87MP0004233_abnormal_muscle_weight1.04899935
88MP0002332_abnormal_exercise_endurance1.04734865
89MP0003693_abnormal_embryo_hatching1.04032604
90MP0005389_reproductive_system_phenotype1.03826358
91MP0008007_abnormal_cellular_replicative1.03759991
92MP0002210_abnormal_sex_determination1.03417774
93MP0002277_abnormal_respiratory_mucosa1.02915338
94MP0005167_abnormal_blood-brain_barrier1.02406387
95MP0003075_altered_response_to1.00206158
96MP0001905_abnormal_dopamine_level0.98823215
97MP0005646_abnormal_pituitary_gland0.98051004
98MP0002249_abnormal_larynx_morphology0.97947291
99MP0010155_abnormal_intestine_physiology0.97875211
100MP0005187_abnormal_penis_morphology0.97799907
101MP0003315_abnormal_perineum_morphology0.97400262
102MP0002693_abnormal_pancreas_physiology0.96974252
103MP0002089_abnormal_postnatal_growth/wei0.94006428
104MP0003077_abnormal_cell_cycle0.93386457
105MP0003868_abnormal_feces_composition0.92877576
106MP0001845_abnormal_inflammatory_respons0.91275569
107MP0004947_skin_inflammation0.89815414
108MP0002163_abnormal_gland_morphology0.89267743
109MP0008469_abnormal_protein_level0.88987129
110MP0002735_abnormal_chemical_nociception0.88985507
111MP0004808_abnormal_hematopoietic_stem0.88824251
112MP0003329_amyloid_beta_deposits0.88055555
113MP0009672_abnormal_birth_weight0.86247222
114MP0004858_abnormal_nervous_system0.85038433
115MP0001944_abnormal_pancreas_morphology0.84829828
116MP0002063_abnormal_learning/memory/cond0.84796898
117MP0000358_abnormal_cell_content/0.84603256
118MP0005266_abnormal_metabolism0.84561964
119MP0003123_paternal_imprinting0.84287475
120MP0008995_early_reproductive_senescence0.83587840
121MP0009333_abnormal_splenocyte_physiolog0.83210486
122MP0008932_abnormal_embryonic_tissue0.82341889
123MP0000313_abnormal_cell_death0.81115743
124MP0005375_adipose_tissue_phenotype0.81059628
125MP0001348_abnormal_lacrimal_gland0.80695510
126MP0001663_abnormal_digestive_system0.79904569
127MP0000613_abnormal_salivary_gland0.79870524
128MP0000647_abnormal_sebaceous_gland0.76520349
129MP0000604_amyloidosis0.76487182
130MP0000681_abnormal_thyroid_gland0.76370678
131MP0003656_abnormal_erythrocyte_physiolo0.75373568
132MP0001533_abnormal_skeleton_physiology0.75254857
133MP0001145_abnormal_male_reproductive0.74804997
134MP0002998_abnormal_bone_remodeling0.74738043
135MP0005670_abnormal_white_adipose0.73637637
136MP0003172_abnormal_lysosome_physiology0.73521104
137MP0002161_abnormal_fertility/fecundity0.72544156
138MP0000858_altered_metastatic_potential0.70304800
139MP0003121_genomic_imprinting0.69951433
140MP0000538_abnormal_urinary_bladder0.68279774
141MP0001853_heart_inflammation0.67755977
142MP0003879_abnormal_hair_cell0.67440108
143MP0000920_abnormal_myelination0.67133862
144MP0000653_abnormal_sex_gland0.66374693
145MP0000249_abnormal_blood_vessel0.65260798
146MP0001119_abnormal_female_reproductive0.64098872
147MP0001243_abnormal_dermal_layer0.62267012
148MP0005075_abnormal_melanosome_morpholog0.59609172
149MP0000470_abnormal_stomach_morphology0.58964145
150MP0003866_abnormal_defecation0.57611146
151MP0000343_altered_response_to0.57506653

Predicted human phenotypes

RankGene SetZ-score
1Curly hair (HP:0002212)6.28378616
2Neoplasm of the adrenal cortex (HP:0100641)5.77452432
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.64895276
4High anterior hairline (HP:0009890)5.36033731
5Volvulus (HP:0002580)5.26911485
6Stomach cancer (HP:0012126)5.24366103
7Recurrent abscess formation (HP:0002722)5.03945729
8Prolonged bleeding time (HP:0003010)4.94027360
9Increased neuronal autofluorescent lipopigment (HP:0002074)4.71890424
10Increased cerebral lipofuscin (HP:0011813)4.65244205
11Hypochromic microcytic anemia (HP:0004840)4.60142774
12Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)4.53995611
13Hepatoblastoma (HP:0002884)4.53225224
14Aplasia/Hypoplasia of the sacrum (HP:0008517)4.30562904
15Wide intermamillary distance (HP:0006610)4.19246694
16Subacute progressive viral hepatitis (HP:0006572)4.18558088
17Bell-shaped thorax (HP:0001591)4.14126272
18Depressed nasal tip (HP:0000437)4.05848161
19Abnormality of glycolipid metabolism (HP:0010969)3.99487851
20Abnormality of liposaccharide metabolism (HP:0010968)3.99487851
21Abnormality of glycosphingolipid metabolism (HP:0004343)3.99487851
22Dynein arm defect of respiratory motile cilia (HP:0012255)3.98118554
23Absent/shortened dynein arms (HP:0200106)3.98118554
24Blue irides (HP:0000635)3.92681329
25Back pain (HP:0003418)3.80581545
26Absent frontal sinuses (HP:0002688)3.77717156
27Severe visual impairment (HP:0001141)3.59157752
28Colon cancer (HP:0003003)3.51480637
29Abnormal umbilical cord blood vessels (HP:0011403)3.41646320
30Single umbilical artery (HP:0001195)3.41646320
31Abnormality of the fetal cardiovascular system (HP:0010948)3.41646320
32Medulloblastoma (HP:0002885)3.27586885
33Abnormal respiratory motile cilium physiology (HP:0012261)3.18757219
34Cubitus valgus (HP:0002967)3.16820627
35Hyperthyroidism (HP:0000836)3.11017682
36Cystic hygroma (HP:0000476)3.03612399
37Viral hepatitis (HP:0006562)3.01888075
38Epidermoid cyst (HP:0200040)2.92058882
39Rhinitis (HP:0012384)2.90329318
40Occipital encephalocele (HP:0002085)2.89485320
41Genetic anticipation (HP:0003743)2.86157518
42Hypochromic anemia (HP:0001931)2.80184562
43Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.79650340
44Chronic bronchitis (HP:0004469)2.77054987
45Chronic otitis media (HP:0000389)2.76788032
46Abnormality of the astrocytes (HP:0100707)2.75571353
47Astrocytoma (HP:0009592)2.75571353
48Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.69659546
49Broad distal phalanx of finger (HP:0009836)2.68291136
50Abnormality of DNA repair (HP:0003254)2.68064547
51Tented upper lip vermilion (HP:0010804)2.64927623
52Abnormal respiratory motile cilium morphology (HP:0005938)2.63722917
53Abnormal respiratory epithelium morphology (HP:0012253)2.63722917
54Papillary thyroid carcinoma (HP:0002895)2.61116173
55Nasal polyposis (HP:0100582)2.59822288
56Abnormal delayed hypersensitivity skin test (HP:0002963)2.57692618
57Eczematoid dermatitis (HP:0000976)2.56830023
58Vacuolated lymphocytes (HP:0001922)2.55969912
59Abnormality of the frontal sinuses (HP:0002687)2.52931352
60Hyperacusis (HP:0010780)2.52641838
61Progressive cerebellar ataxia (HP:0002073)2.51817393
62Uterine leiomyosarcoma (HP:0002891)2.50724652
63Leiomyosarcoma (HP:0100243)2.50724652
64Prolonged neonatal jaundice (HP:0006579)2.50168990
65Chromosomal breakage induced by crosslinking agents (HP:0003221)2.48336104
66Spastic tetraparesis (HP:0001285)2.47521036
67Glioma (HP:0009733)2.46704891
68Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.46053638
69Dysostosis multiplex (HP:0000943)2.46046212
70Abnormality of mucopolysaccharide metabolism (HP:0011020)2.45476133
71Abnormality of polysaccharide metabolism (HP:0011012)2.45476133
72Abnormality of glycosaminoglycan metabolism (HP:0004371)2.45476133
73Optic nerve coloboma (HP:0000588)2.44629871
74Protruding tongue (HP:0010808)2.44303855
75Adrenal hypoplasia (HP:0000835)2.39896869
76Albinism (HP:0001022)2.37514468
77Fibroma (HP:0010614)2.36893572
78Limb hypertonia (HP:0002509)2.36341440
79Congenital stationary night blindness (HP:0007642)2.35408397
80Nuclear cataract (HP:0100018)2.35055878
81Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.31656922
82Obstructive lung disease (HP:0006536)2.31416120
83Chronic obstructive pulmonary disease (HP:0006510)2.31416120
84Tubulointerstitial fibrosis (HP:0005576)2.30951864
85Myelomeningocele (HP:0002475)2.30551570
86Abnormality of the columella (HP:0009929)2.29413763
87Urethral obstruction (HP:0000796)2.29048892
88Severe muscular hypotonia (HP:0006829)2.28569159
89Meningitis (HP:0001287)2.28174785
90Fibrous tissue neoplasm (HP:0012316)2.28135582
91Bronchiectasis (HP:0002110)2.27021494
92Barrel-shaped chest (HP:0001552)2.25168703
93Maternal diabetes (HP:0009800)2.24849332
94Retinal atrophy (HP:0001105)2.22418375
95Chronic mucocutaneous candidiasis (HP:0002728)2.20171669
96Recurrent cutaneous fungal infections (HP:0011370)2.20171669
97Neoplasm of the oral cavity (HP:0100649)2.19478965
98Chest pain (HP:0100749)2.19416488
99Deep palmar crease (HP:0006191)2.18858927
100Recurrent otitis media (HP:0000403)2.16213635
101Abnormality of the nasal mucosa (HP:0000433)2.15374550
102Microretrognathia (HP:0000308)2.15373169
103Recurrent fungal infections (HP:0002841)2.14881160
104Patellar aplasia (HP:0006443)2.13160359
105Hypertensive crisis (HP:0100735)2.12709015
106Flat cornea (HP:0007720)2.11913609
107Supernumerary ribs (HP:0005815)2.11727372
108Bronchitis (HP:0012387)2.11711735
109Impulsivity (HP:0100710)2.09325098
110Retinal dysplasia (HP:0007973)2.09234771
111Stomatitis (HP:0010280)2.08538904
112Acute lymphatic leukemia (HP:0006721)2.08172033
113Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.07620415
114Micronodular cirrhosis (HP:0001413)2.07360633
115Fibular hypoplasia (HP:0003038)2.07330943
116Truncal obesity (HP:0001956)2.05168189
117Ectopic kidney (HP:0000086)2.02298726
118Aplasia/Hypoplasia of the patella (HP:0006498)2.02115056
119Abnormality of the aortic arch (HP:0012303)2.00958219
120Supernumerary bones of the axial skeleton (HP:0009144)2.00819908
121Neoplasm of the adrenal gland (HP:0100631)2.00681111
122Type II lissencephaly (HP:0007260)1.99957228
123Chromsome breakage (HP:0040012)1.99495902
124Bowel incontinence (HP:0002607)1.98876117
125Recurrent bacterial skin infections (HP:0005406)1.98795218
126Transposition of the great arteries (HP:0001669)1.97548951
127Abnormal connection of the cardiac segments (HP:0011545)1.97548951
128Abnormal ventriculo-arterial connection (HP:0011563)1.97548951
129Chronic sinusitis (HP:0011109)1.96181713
130Multiple lipomas (HP:0001012)1.96137481
131Ileus (HP:0002595)1.94609181
132Transitional cell carcinoma of the bladder (HP:0006740)1.94135632
133Long eyelashes (HP:0000527)1.92888494
134Abnormality of the heme biosynthetic pathway (HP:0010472)1.91378047
135Self-mutilation (HP:0000742)1.91005592
136Abnormal large intestine physiology (HP:0012700)1.89214823
137Truncus arteriosus (HP:0001660)1.88672831
138Chronic hepatic failure (HP:0100626)1.88213446
139Agitation (HP:0000713)1.87944322
140Radioulnar synostosis (HP:0002974)1.87905410
141Abnormality of the umbilical cord (HP:0010881)1.87615265
142Molar tooth sign on MRI (HP:0002419)1.87345362
143Abnormality of midbrain morphology (HP:0002418)1.87345362
144Abnormal rod and cone electroretinograms (HP:0008323)1.86857779
145Thin bony cortex (HP:0002753)1.86495195
146Recurrent sinusitis (HP:0011108)1.86089128
147Elevated erythrocyte sedimentation rate (HP:0003565)1.85788954
148Progressive microcephaly (HP:0000253)1.85727144
149Atelectasis (HP:0100750)1.83888049
150Mucopolysacchariduria (HP:0008155)1.83861618
151Urinary glycosaminoglycan excretion (HP:0003541)1.83861618
152Short tibia (HP:0005736)1.83190023
153Coarse hair (HP:0002208)1.83169806
154Abnormality of the vertebral endplates (HP:0005106)1.82260485
155Mesangial abnormality (HP:0001966)1.82257392
156Intellectual disability, progressive (HP:0006887)1.81070209
157Facial hemangioma (HP:0000329)1.79434895
158Lissencephaly (HP:0001339)1.79306076
159Cerebellar dysplasia (HP:0007033)1.78892829
160Mediastinal lymphadenopathy (HP:0100721)1.78884986
161Gingivitis (HP:0000230)1.77745527
162Loss of speech (HP:0002371)1.75906601
163Large for gestational age (HP:0001520)1.75551206
164J-shaped sella turcica (HP:0002680)1.74193177
165Neuronal loss in central nervous system (HP:0002529)1.72077797
166Poikiloderma (HP:0001029)1.71905003
167Attenuation of retinal blood vessels (HP:0007843)1.71873097
168Testicular atrophy (HP:0000029)1.71119530
169Renovascular hypertension (HP:0100817)1.71063616
170Increased serum ferritin (HP:0003281)1.68593683
171Bony spicule pigmentary retinopathy (HP:0007737)1.68555120
172Clumsiness (HP:0002312)1.68430443
173Upper limb amyotrophy (HP:0009129)1.66556041
174Distal upper limb amyotrophy (HP:0007149)1.66556041
175Heterotopia (HP:0002282)1.65800602
176Reticulocytopenia (HP:0001896)1.64850552
177Autoimmune thrombocytopenia (HP:0001973)1.64074187
178Poor head control (HP:0002421)1.63480690
179Hemiparesis (HP:0001269)1.62145356
180Obsessive-compulsive behavior (HP:0000722)1.61918852
181Flattened epiphyses (HP:0003071)1.61569216
182Personality changes (HP:0000751)1.61563404
183Rectal prolapse (HP:0002035)1.61394021
184Dysautonomia (HP:0002459)1.61112848
185Supranuclear gaze palsy (HP:0000605)1.60603063
186Short thumb (HP:0009778)1.59747614
187Patellar dislocation (HP:0002999)1.59672052
188Abnormal number of incisors (HP:0011064)1.58944431
189Slender long bone (HP:0003100)1.58456517
190Stereotypic behavior (HP:0000733)1.57863830

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.79374115
2FRK3.50745818
3LATS12.97991302
4PINK12.74654401
5GRK62.63321808
6MAP4K12.38562553
7CSNK1A1L2.35900019
8TXK2.31841152
9ZAK2.29801274
10CAMK1D2.16121307
11MAP3K112.04126196
12PRKD32.03969534
13ICK10.3272271
14PRPF4B1.97854019
15SIK31.97851745
16CAMK1G1.94594595
17IRAK41.89733777
18SIK11.89649688
19CSNK1G31.88774735
20IRAK31.86525019
21SMG11.81157262
22TAOK11.69845119
23IRAK21.59525203
24TYRO31.59131588
25DDR21.57941960
26TESK11.54467002
27ERN11.53683691
28CDK71.52488597
29TLK11.47874344
30TAOK21.45829620
31BTK1.43674448
32NUAK11.42934054
33JAK31.41533689
34CDC42BPA1.41383575
35INSRR1.40702462
36CSK1.40669441
37CSNK1G11.39421363
38IRAK11.34808303
39CSNK1G21.33491642
40PIM11.33000780
41MAP3K141.29520832
42TNK21.27173175
43PNCK1.24073480
44RIPK41.19738802
45TEC1.15794389
46MARK21.15688474
47ADRBK21.14460327
48YES11.12140864
49PRKD21.04110113
50NEK21.01624014
51PTK60.98849959
52ZAP700.98724460
53NTRK30.98442304
54DYRK1B0.97895397
55MUSK0.96880879
56BUB10.95197947
57SIK20.93681184
58TYK20.92886316
59ITK0.92280403
60MATK0.91973950
61MAPK110.85336276
62HCK0.83979622
63CLK10.82826959
64CAMKK10.81240961
65BRAF0.81193064
66MAP3K130.79252276
67STK30.77171051
68MAP3K10.76680732
69MAP2K60.76009078
70PDK30.75783604
71PDK40.75783604
72CHUK0.75052046
73CSF1R0.74212647
74SYK0.73088710
75ACVR1B0.72988809
76MAP3K70.70575476
77KIT0.68388872
78PLK40.67106401
79JAK10.66804866
80IKBKB0.66401072
81RPS6KA60.65691026
82PDPK10.64704413
83MAPKAPK50.64631144
84CCNB10.64410868
85SGK30.62491645
86GRK70.61902924
87CAMKK20.61465650
88EEF2K0.61153213
89HIPK20.59062153
90IKBKE0.57940124
91BLK0.57235893
92MAPK70.57031330
93PRKCI0.56862468
94RPS6KA20.56002072
95PRKCH0.54860418
96STK100.52934185
97MAP3K80.52244297
98MAP2K20.50769907
99RPS6KC10.50267555
100RPS6KL10.50267555
101LCK0.49666541
102BMPR1B0.46756685
103PDK10.45982651
104TBK10.45735126
105NLK0.45448676
106ALK0.45301437
107PKN10.45200642
108DYRK30.43931793
109DAPK20.43894329
110ATR0.43011526
111LYN0.42716318
112BRD40.41809622
113MAPK80.41248802
114ABL20.41053978
115PKN20.40890009
116MAP4K20.40323666
117PDK20.40261930
118NME20.39336365
119SGK20.38967268
120PRKCG0.36364383
121CSNK1A10.35679818
122AURKA0.35037035
123RPS6KA10.34991496
124AKT30.34055535
125PAK60.33499814
126PRKCZ0.33119271
127STK380.32441421
128CAMK10.32051690
129BCKDK0.32013253
130CDK80.31794415
131MARK30.31367799
132CDK120.29936852
133MTOR0.29509981
134PIM20.28006831
135PRKCD0.27078591
136AKT10.26158120
137FES0.25665964
138STK40.24361775
139CDK20.24085517
140ERBB30.23459820
141CHEK20.23449125
142BMPR20.22992715
143CDK30.22868136
144CHEK10.22174121
145EPHB10.21146473
146MAPK30.21068727
147CAMK40.20486752
148CDK40.20447297
149MAPK130.20418737
150MAPK140.19927054
151DAPK10.19912343
152ATM0.19805058
153MAP2K30.18947064
154MAP3K100.18256418
155TTK0.17120674
156GSK3B0.14748936

Predicted pathways (KEGG)

RankGene SetZ-score
1Dorso-ventral axis formation_Homo sapiens_hsa043203.15061430
2Endometrial cancer_Homo sapiens_hsa052132.65303088
3Acute myeloid leukemia_Homo sapiens_hsa052212.64054190
4B cell receptor signaling pathway_Homo sapiens_hsa046622.30125159
5Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.21944057
6Primary immunodeficiency_Homo sapiens_hsa053402.20547954
7Fc epsilon RI signaling pathway_Homo sapiens_hsa046642.07032147
8T cell receptor signaling pathway_Homo sapiens_hsa046602.05202670
9Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.98757735
10Bladder cancer_Homo sapiens_hsa052191.86544488
11NF-kappa B signaling pathway_Homo sapiens_hsa040641.74033552
12Base excision repair_Homo sapiens_hsa034101.70194180
13Intestinal immune network for IgA production_Homo sapiens_hsa046721.69153524
14NOD-like receptor signaling pathway_Homo sapiens_hsa046211.68077924
15Chronic myeloid leukemia_Homo sapiens_hsa052201.63046347
16DNA replication_Homo sapiens_hsa030301.61753825
17Selenocompound metabolism_Homo sapiens_hsa004501.61667588
18Measles_Homo sapiens_hsa051621.61485168
19Prolactin signaling pathway_Homo sapiens_hsa049171.52887773
20Leishmaniasis_Homo sapiens_hsa051401.52268655
21Non-small cell lung cancer_Homo sapiens_hsa052231.49473086
22Sulfur relay system_Homo sapiens_hsa041221.44298149
23Osteoclast differentiation_Homo sapiens_hsa043801.44169285
24Lysine degradation_Homo sapiens_hsa003101.42246617
25Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.42115175
26Chemokine signaling pathway_Homo sapiens_hsa040621.40492488
27African trypanosomiasis_Homo sapiens_hsa051431.39941716
28VEGF signaling pathway_Homo sapiens_hsa043701.38301927
29Rheumatoid arthritis_Homo sapiens_hsa053231.37203179
30Fanconi anemia pathway_Homo sapiens_hsa034601.37110026
31Toll-like receptor signaling pathway_Homo sapiens_hsa046201.36841294
32Nicotine addiction_Homo sapiens_hsa050331.35881452
33Basal cell carcinoma_Homo sapiens_hsa052171.33617223
34Jak-STAT signaling pathway_Homo sapiens_hsa046301.32178866
35Glioma_Homo sapiens_hsa052141.30561044
36Type II diabetes mellitus_Homo sapiens_hsa049301.28247829
37Adipocytokine signaling pathway_Homo sapiens_hsa049201.27977585
38Herpes simplex infection_Homo sapiens_hsa051681.25304745
39Hematopoietic cell lineage_Homo sapiens_hsa046401.21224426
40Fatty acid biosynthesis_Homo sapiens_hsa000611.19926643
41Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.18681987
42Neurotrophin signaling pathway_Homo sapiens_hsa047221.18327540
43Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.17703257
44Sphingolipid metabolism_Homo sapiens_hsa006001.10195797
45Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.09886858
46Influenza A_Homo sapiens_hsa051641.09114064
47RNA polymerase_Homo sapiens_hsa030201.08125673
48Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.07080139
49Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.05304779
50Transcriptional misregulation in cancer_Homo sapiens_hsa052021.04818823
51Pyrimidine metabolism_Homo sapiens_hsa002401.04492473
52ErbB signaling pathway_Homo sapiens_hsa040121.03719077
53Allograft rejection_Homo sapiens_hsa053301.01581985
54Prion diseases_Homo sapiens_hsa050200.99031462
55Alcoholism_Homo sapiens_hsa050340.98780798
56Apoptosis_Homo sapiens_hsa042100.98678381
57Synaptic vesicle cycle_Homo sapiens_hsa047210.97423980
58FoxO signaling pathway_Homo sapiens_hsa040680.95318016
59Long-term potentiation_Homo sapiens_hsa047200.94220419
60Graft-versus-host disease_Homo sapiens_hsa053320.93775736
61Estrogen signaling pathway_Homo sapiens_hsa049150.91566704
62RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.89165268
63Hepatitis C_Homo sapiens_hsa051600.86475803
64Colorectal cancer_Homo sapiens_hsa052100.86297823
65Phospholipase D signaling pathway_Homo sapiens_hsa040720.84443388
66Toxoplasmosis_Homo sapiens_hsa051450.84007657
67Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.83496793
68Salmonella infection_Homo sapiens_hsa051320.83409188
69Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.82471863
70mTOR signaling pathway_Homo sapiens_hsa041500.81891250
71GnRH signaling pathway_Homo sapiens_hsa049120.81338235
72Tuberculosis_Homo sapiens_hsa051520.81110454
73Cocaine addiction_Homo sapiens_hsa050300.80287790
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.79362741
75Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.78237151
76Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.77087862
77Prostate cancer_Homo sapiens_hsa052150.76896291
78Antigen processing and presentation_Homo sapiens_hsa046120.76738458
79HTLV-I infection_Homo sapiens_hsa051660.75729176
80Glycosaminoglycan degradation_Homo sapiens_hsa005310.74927282
81Amphetamine addiction_Homo sapiens_hsa050310.74556474
82Taste transduction_Homo sapiens_hsa047420.73965202
83Carbohydrate digestion and absorption_Homo sapiens_hsa049730.73296612
84TNF signaling pathway_Homo sapiens_hsa046680.72009802
85MAPK signaling pathway_Homo sapiens_hsa040100.71096844
86Renal cell carcinoma_Homo sapiens_hsa052110.70663073
87MicroRNAs in cancer_Homo sapiens_hsa052060.69313185
88Choline metabolism in cancer_Homo sapiens_hsa052310.69283173
89Spliceosome_Homo sapiens_hsa030400.68942637
90Pathways in cancer_Homo sapiens_hsa052000.68388528
91Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.67492950
92Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.67308937
93Other glycan degradation_Homo sapiens_hsa005110.67262804
94Calcium signaling pathway_Homo sapiens_hsa040200.65883943
95Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65815323
96Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.65072427
97Homologous recombination_Homo sapiens_hsa034400.65003920
98Epstein-Barr virus infection_Homo sapiens_hsa051690.63916613
99Circadian entrainment_Homo sapiens_hsa047130.63884273
100Cyanoamino acid metabolism_Homo sapiens_hsa004600.63631870
101Regulation of actin cytoskeleton_Homo sapiens_hsa048100.62090166
102Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61826256
103Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60967920
104Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.60728589
105Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.60540557
106Type I diabetes mellitus_Homo sapiens_hsa049400.60158968
107Collecting duct acid secretion_Homo sapiens_hsa049660.59655769
108Hepatitis B_Homo sapiens_hsa051610.57983040
109Pertussis_Homo sapiens_hsa051330.57970446
110Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57868771
111SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57556226
112Fructose and mannose metabolism_Homo sapiens_hsa000510.56850455
113Phototransduction_Homo sapiens_hsa047440.56770198
114AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.56431782
115Inositol phosphate metabolism_Homo sapiens_hsa005620.55994090
116Legionellosis_Homo sapiens_hsa051340.55116006
117Glutamatergic synapse_Homo sapiens_hsa047240.53494650
118Notch signaling pathway_Homo sapiens_hsa043300.52464376
119Gap junction_Homo sapiens_hsa045400.50960294
120Morphine addiction_Homo sapiens_hsa050320.49859708
121Insulin signaling pathway_Homo sapiens_hsa049100.49411307
122Lysosome_Homo sapiens_hsa041420.49402241
123ABC transporters_Homo sapiens_hsa020100.48682935
124Leukocyte transendothelial migration_Homo sapiens_hsa046700.48013459
125Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.48013344
126Viral carcinogenesis_Homo sapiens_hsa052030.47083092
127Staphylococcus aureus infection_Homo sapiens_hsa051500.46322653
128Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.46231022
129Systemic lupus erythematosus_Homo sapiens_hsa053220.45757321
130Asthma_Homo sapiens_hsa053100.45683029
131Malaria_Homo sapiens_hsa051440.45556834
132Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.45385518
133Wnt signaling pathway_Homo sapiens_hsa043100.43673010
134Ether lipid metabolism_Homo sapiens_hsa005650.42718822
135mRNA surveillance pathway_Homo sapiens_hsa030150.41004530
136Tryptophan metabolism_Homo sapiens_hsa003800.40706777
137Insulin secretion_Homo sapiens_hsa049110.39509273
138Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.39405919
139Aldosterone synthesis and secretion_Homo sapiens_hsa049250.36886943

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