SMIM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a small, conserved protein that participates in red blood cell formation. The encoded protein is localized to the cell membrane and is the antigen for the Vel blood group. Alternative splicing results in different transcript variants that encode the same protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protoporphyrinogen IX metabolic process (GO:0046501)8.39376021
2protoporphyrinogen IX biosynthetic process (GO:0006782)8.26930790
3central nervous system myelination (GO:0022010)8.25627899
4axon ensheathment in central nervous system (GO:0032291)8.25627899
5hemoglobin metabolic process (GO:0020027)7.81724771
6heme biosynthetic process (GO:0006783)6.68736338
7erythrocyte development (GO:0048821)6.53543443
8porphyrin-containing compound biosynthetic process (GO:0006779)5.73607875
9heme metabolic process (GO:0042168)5.46443679
10deoxyribonucleoside monophosphate metabolic process (GO:0009162)5.38605016
11tetrapyrrole biosynthetic process (GO:0033014)5.27725759
12signal peptide processing (GO:0006465)5.07862704
13mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.80768563
14response to lead ion (GO:0010288)4.79170974
15response to methylmercury (GO:0051597)4.79141214
16granulocyte differentiation (GO:0030851)4.72508218
17porphyrin-containing compound metabolic process (GO:0006778)4.64332999
18mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.63101269
19ATP synthesis coupled proton transport (GO:0015986)4.58113658
20energy coupled proton transport, down electrochemical gradient (GO:0015985)4.58113658
21myeloid cell development (GO:0061515)4.53878591
22ensheathment of neurons (GO:0007272)4.42761529
23axon ensheathment (GO:0008366)4.42761529
24myelination (GO:0042552)4.38332849
25fatty acid elongation (GO:0030497)4.32648987
26positive regulation of megakaryocyte differentiation (GO:0045654)4.10891320
27myelin maintenance (GO:0043217)4.03068968
28respiratory electron transport chain (GO:0022904)4.02406244
29GPI anchor biosynthetic process (GO:0006506)3.93272311
30electron transport chain (GO:0022900)3.92148405
31negative regulation of erythrocyte differentiation (GO:0045647)3.90391814
32mannosylation (GO:0097502)3.83320898
33cotranslational protein targeting to membrane (GO:0006613)3.81513693
34protein targeting to ER (GO:0045047)3.75977636
35L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.75254685
36SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.72333412
37protein neddylation (GO:0045116)3.68772971
382-deoxyribonucleotide biosynthetic process (GO:0009265)3.66922860
39deoxyribose phosphate biosynthetic process (GO:0046385)3.66922860
40modulation by virus of host process (GO:0019054)3.63084412
41establishment of protein localization to endoplasmic reticulum (GO:0072599)3.62690442
42pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.62684981
43regulation of response to osmotic stress (GO:0047484)3.61216324
44protein localization to endoplasmic reticulum (GO:0070972)3.60796194
45tetrapyrrole metabolic process (GO:0033013)3.52368239
46positive regulation of granulocyte differentiation (GO:0030854)3.50622886
47diol metabolic process (GO:0034311)3.48875056
48preassembly of GPI anchor in ER membrane (GO:0016254)3.47458444
49pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.46243210
50hydrogen peroxide catabolic process (GO:0042744)3.45685677
51creatine metabolic process (GO:0006600)3.41706814
52GPI anchor metabolic process (GO:0006505)3.39635965
53positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)3.38206934
54definitive hemopoiesis (GO:0060216)3.33380222
55erythrocyte maturation (GO:0043249)3.33240449
56magnesium ion transport (GO:0015693)3.31500811
57GDP-mannose metabolic process (GO:0019673)3.28813120
58peptidyl-cysteine modification (GO:0018198)3.28463895
59sphingoid metabolic process (GO:0046519)3.28129358
60platelet formation (GO:0030220)3.27728050
61import into cell (GO:0098657)3.24938411
62erythrocyte differentiation (GO:0030218)3.24659229
63response to redox state (GO:0051775)3.22743543
64purine-containing compound salvage (GO:0043101)3.22323856
65regulation of erythrocyte differentiation (GO:0045646)3.21884048
66amyloid precursor protein metabolic process (GO:0042982)3.18066605
67pigment biosynthetic process (GO:0046148)3.17711763
68oligodendrocyte differentiation (GO:0048709)3.17353114
69viral transcription (GO:0019083)3.17147669
70megakaryocyte development (GO:0035855)3.15973296
71proteasome assembly (GO:0043248)3.13379415
72sphingosine metabolic process (GO:0006670)3.12798275
73termination of RNA polymerase III transcription (GO:0006386)3.11638026
74transcription elongation from RNA polymerase III promoter (GO:0006385)3.11638026
75protein complex biogenesis (GO:0070271)3.09950526
76heme transport (GO:0015886)3.09784046
77negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.09399655
78pentose metabolic process (GO:0019321)3.09363906
79chaperone-mediated protein transport (GO:0072321)3.09235932
80one-carbon compound transport (GO:0019755)3.07514713
81response to insecticide (GO:0017085)3.04736853
82nucleoside diphosphate catabolic process (GO:0009134)3.04218043
83translational termination (GO:0006415)3.03789652
84very-low-density lipoprotein particle assembly (GO:0034379)3.03105884
85protein maturation by protein folding (GO:0022417)3.02590788
86negative regulation of execution phase of apoptosis (GO:1900118)3.01814570
87autophagic vacuole fusion (GO:0000046)3.01477889
88long-chain fatty acid biosynthetic process (GO:0042759)3.00563800
89mitochondrial respiratory chain complex I assembly (GO:0032981)3.00165830
90NADH dehydrogenase complex assembly (GO:0010257)3.00165830
91mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.00165830
92cholesterol biosynthetic process (GO:0006695)2.97062313
93neutrophil activation involved in immune response (GO:0002283)2.92054755
94cellular response to thyroid hormone stimulus (GO:0097067)2.89067257
95peptidyl-histidine modification (GO:0018202)2.86684316
96amino acid salvage (GO:0043102)2.86607042
97L-methionine salvage (GO:0071267)2.86607042
98L-methionine biosynthetic process (GO:0071265)2.86607042
99phosphatidylethanolamine biosynthetic process (GO:0006646)2.86496845
100GTP biosynthetic process (GO:0006183)2.86317292
101embryonic hemopoiesis (GO:0035162)2.84901210
102modulation by symbiont of host cellular process (GO:0044068)2.82308310
103ribosomal small subunit assembly (GO:0000028)2.82300871
104glycosylceramide metabolic process (GO:0006677)2.82197324
105ribosomal small subunit biogenesis (GO:0042274)2.81831164
106positive regulation of erythrocyte differentiation (GO:0045648)2.81494649
107pyrimidine nucleotide catabolic process (GO:0006244)2.80359823
108iron-sulfur cluster assembly (GO:0016226)2.79293519
109metallo-sulfur cluster assembly (GO:0031163)2.79293519
110nucleotide transmembrane transport (GO:1901679)2.77901443
111proline biosynthetic process (GO:0006561)2.76095052
112phosphatidylserine acyl-chain remodeling (GO:0036150)2.74595503
113pigment metabolic process (GO:0042440)2.74253131
114positive regulation of cellular amine metabolic process (GO:0033240)2.73076355
115water-soluble vitamin biosynthetic process (GO:0042364)2.72745863
116mitochondrial respiratory chain complex assembly (GO:0033108)2.71025120
117respiratory chain complex IV assembly (GO:0008535)2.70940998
118plasma lipoprotein particle assembly (GO:0034377)2.70355758
119poly(A)+ mRNA export from nucleus (GO:0016973)2.68440774
120negative regulation of JUN kinase activity (GO:0043508)2.68264700
121short-chain fatty acid metabolic process (GO:0046459)2.68156688
122negative regulation of neurotransmitter secretion (GO:0046929)2.66382644
123C-terminal protein lipidation (GO:0006501)2.65842601
124photoreceptor cell differentiation (GO:0046530)2.65199337
125eye photoreceptor cell differentiation (GO:0001754)2.65199337
126protein-cofactor linkage (GO:0018065)2.64675201
127isoprenoid biosynthetic process (GO:0008299)2.64295927
128protein targeting to mitochondrion (GO:0006626)2.63580825
129negative regulation of fatty acid biosynthetic process (GO:0045717)2.63563469
130viral protein processing (GO:0019082)2.63081510
131protein palmitoylation (GO:0018345)2.62435291
132positive regulation of oligodendrocyte differentiation (GO:0048714)2.62301513
133protein targeting to membrane (GO:0006612)2.61709455
134hydrogen ion transmembrane transport (GO:1902600)2.61514788
135translation (GO:0006412)2.60627847
136sterol biosynthetic process (GO:0016126)2.59026225
137regulation of lipoprotein metabolic process (GO:0050746)2.57908905
138organelle membrane fusion (GO:0090174)2.57655818
139GMP metabolic process (GO:0046037)2.57503647
140negative regulation of protein localization to cell surface (GO:2000009)2.57394212
141dopamine biosynthetic process (GO:0042416)2.56914489
142phosphatidylethanolamine metabolic process (GO:0046337)2.56491540
143protein autoprocessing (GO:0016540)2.55745991
144negative regulation of neurotransmitter transport (GO:0051589)2.54613530
145mitochondrial calcium ion transport (GO:0006851)2.54131919
146cellular response to arsenic-containing substance (GO:0071243)2.53805874
147oxidative phosphorylation (GO:0006119)2.53631676
148DNA deamination (GO:0045006)2.52123703
149peptide biosynthetic process (GO:0043043)2.52053609
150regulation of mast cell degranulation (GO:0043304)2.49261732
151viral life cycle (GO:0019058)2.49210775
152translational elongation (GO:0006414)2.47849257
153regulation of cholesterol esterification (GO:0010872)2.47678651
154potassium ion export (GO:0071435)2.46653806
155response to thyroid hormone (GO:0097066)2.46000917
1562-deoxyribonucleotide metabolic process (GO:0009394)2.44027639
157deoxyribonucleotide biosynthetic process (GO:0009263)2.43933673
158glycine transport (GO:0015816)2.43923701
159glutathione derivative biosynthetic process (GO:1901687)2.43682433
160glutathione derivative metabolic process (GO:1901685)2.43682433
161regulation of chromatin binding (GO:0035561)2.42364625
162ATP biosynthetic process (GO:0006754)2.41849591
163virion assembly (GO:0019068)2.40871361
164negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.40151579
165regulation of megakaryocyte differentiation (GO:0045652)2.39886712
166hydrogen peroxide metabolic process (GO:0042743)2.39831733
167establishment of protein localization to mitochondrion (GO:0072655)2.39048266
168nucleoside diphosphate biosynthetic process (GO:0009133)2.37959338
169deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.37617601
170homocysteine metabolic process (GO:0050667)2.37264814
171deoxyribose phosphate metabolic process (GO:0019692)2.36499624
172oxygen transport (GO:0015671)12.7971359
173gas transport (GO:0015669)11.3235543

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.70796424
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.24853412
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.68802568
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.49028064
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.43830360
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.42928647
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.41049742
8PDX1_19855005_ChIP-ChIP_MIN6_Mouse3.33037019
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.04566129
10E2F7_22180533_ChIP-Seq_HELA_Human3.00451842
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.98680879
12GATA1_22025678_ChIP-Seq_K562_Human2.87038416
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.80476909
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.74120505
15SCL_19346495_ChIP-Seq_HPC-7_Human2.52115063
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.51278956
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.49260309
18CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.34860695
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.32621311
20HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.32276332
21GATA2_19941826_ChIP-Seq_K562_Human2.15123091
22NCOR1_26117541_ChIP-Seq_K562_Human2.09625061
23SRF_21415370_ChIP-Seq_HL-1_Mouse2.07277957
24GATA1_19941826_ChIP-Seq_K562_Human2.06175166
25ZNF263_19887448_ChIP-Seq_K562_Human2.03432356
26VDR_21846776_ChIP-Seq_THP-1_Human1.98361632
27HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.93190367
28THAP11_20581084_ChIP-Seq_MESCs_Mouse1.90617696
29SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.83843363
30MYC_18358816_ChIP-ChIP_MESCs_Mouse1.83593623
31DCP1A_22483619_ChIP-Seq_HELA_Human1.77136264
32TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.76288847
33FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.74240971
34SRY_22984422_ChIP-ChIP_TESTIS_Rat1.71432775
35PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.71096083
36ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.69944058
37PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.68424831
38E2F1_18555785_ChIP-Seq_MESCs_Mouse1.59212120
39VDR_23849224_ChIP-Seq_CD4+_Human1.58126551
40MYC_18555785_ChIP-Seq_MESCs_Mouse1.57116516
41RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.56134102
42MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.55787059
43MYC_22102868_ChIP-Seq_BL_Human1.55208927
44KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.51220494
45GATA1_22383799_ChIP-Seq_G1ME_Mouse1.48416486
46PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.47400611
47TRIM28_21343339_ChIP-Seq_HEK293_Human1.47198130
48BCL6_27268052_Chip-Seq_Bcells_Human1.45281830
49IRF1_19129219_ChIP-ChIP_H3396_Human1.42895417
50CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.41844322
51BCOR_27268052_Chip-Seq_Bcells_Human1.41634025
52ELF1_20517297_ChIP-Seq_JURKAT_Human1.40764048
53SOX17_20123909_ChIP-Seq_XEN_Mouse1.39139827
54ELF1_17652178_ChIP-ChIP_JURKAT_Human1.38804227
55ERG_20887958_ChIP-Seq_HPC-7_Mouse1.36136970
56MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.34921103
57ELK1_22589737_ChIP-Seq_MCF10A_Human1.34635788
58CTCF_27219007_Chip-Seq_ERYTHROID_Human1.34499087
59DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.34289633
60P68_20966046_ChIP-Seq_HELA_Human1.32992510
61GATA1_19941827_ChIP-Seq_MEL_Mouse1.32177198
62SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.32151371
63XRN2_22483619_ChIP-Seq_HELA_Human1.31484857
64LXR_22292898_ChIP-Seq_THP-1_Human1.31385638
65CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.31194301
66LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.29978390
67FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.29756425
68FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.29431737
69GABP_19822575_ChIP-Seq_HepG2_Human1.29036965
70ELK3_25401928_ChIP-Seq_HUVEC_Human1.25571790
71KDM5A_27292631_Chip-Seq_BREAST_Human1.24492500
72MAF_26560356_Chip-Seq_TH1_Human1.22921022
73FOXP3_21729870_ChIP-Seq_TREG_Human1.22585361
74STAT1_20625510_ChIP-Seq_HELA_Human1.21799503
75SA1_27219007_Chip-Seq_ERYTHROID_Human1.21737915
76YY1_21170310_ChIP-Seq_MESCs_Mouse1.21382276
77SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.21242818
78UTX_26944678_Chip-Seq_JUKART_Human1.20376203
79CTCF_21964334_Chip-Seq_Bcells_Human1.20310764
80CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.18501923
81SPI1_23547873_ChIP-Seq_NB4_Human1.17688324
82MYC_19030024_ChIP-ChIP_MESCs_Mouse1.17386942
83GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.17353580
84GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17258819
85SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.16028440
86PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.15797212
87DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.15364418
88BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.15153260
89YY1_22570637_ChIP-Seq_MALME-3M_Human1.14963873
90THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.14547097
91CTCF_20526341_ChIP-Seq_ESCs_Human1.14543905
92MAF_26560356_Chip-Seq_TH2_Human1.12088167
93TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.11905427
94VDR_22108803_ChIP-Seq_LS180_Human1.11301150
95RUNX1_22412390_ChIP-Seq_EML_Mouse1.11143055
96SPI1_23127762_ChIP-Seq_K562_Human1.10837638
97GATA2_22383799_ChIP-Seq_G1ME_Mouse1.10011849
98VDR_24763502_ChIP-Seq_THP-1_Human1.09736358
99TBX5_21415370_ChIP-Seq_HL-1_Mouse1.09236653
100KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.08974252
101CTCF_21964334_ChIP-Seq_BJAB-B_Human1.08391534
102CTCF_18555785_ChIP-Seq_MESCs_Mouse1.07598936
103TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.07543314
104CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.07422430
105SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05454185
106GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.05415626
107E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.05188338
108BP1_19119308_ChIP-ChIP_Hs578T_Human1.05133236
109TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.04682851
110NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.04413971
111CIITA_25753668_ChIP-Seq_RAJI_Human1.04269976
112TTF2_22483619_ChIP-Seq_HELA_Human1.03374242
113PPARA_22158963_ChIP-Seq_LIVER_Mouse1.03341076
114CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.01650985
115EOMES_21245162_ChIP-Seq_HESCs_Human0.98830628
116CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.95601322
117LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.94100018
118ELK1_19687146_ChIP-ChIP_HELA_Human0.92740729
119NANOG_20526341_ChIP-Seq_ESCs_Human0.92331200
120TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.91545186
121SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90826282
122FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.88016540
123FOXP1_21924763_ChIP-Seq_HESCs_Human0.84800839
124KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.83905575
125TFEB_21752829_ChIP-Seq_HELA_Human0.83888188
126CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.83358290
127SOX2_27498859_Chip-Seq_STOMACH_Mouse0.82667893
128HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.82053997
129HOXB4_20404135_ChIP-ChIP_EML_Mouse0.81354909
130PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.80910805
131ETV2_25802403_ChIP-Seq_MESCs_Mouse0.80499660
132ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.80097786
133SOX2_16153702_ChIP-ChIP_HESCs_Human0.79542591
134HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.79403043
135MYC_19079543_ChIP-ChIP_MESCs_Mouse0.79105068
136TP53_22573176_ChIP-Seq_HFKS_Human0.77322266
137EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.77137653
138ZFX_18555785_ChIP-Seq_MESCs_Mouse0.77076526
139E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.76876822
140MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.75773733
141ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.74921357
142SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.74598802
143ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.73689929
144MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.70900824
145BMI1_23680149_ChIP-Seq_NPCS_Mouse0.68959019
146CSB_26484114_Chip-Seq_FIBROBLAST_Human0.68744126
147SMC3_22415368_ChIP-Seq_MEFs_Mouse0.68380236
148LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.68106729
149SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.68032753
150MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.67988663
151RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.67740846
152NELFA_20434984_ChIP-Seq_ESCs_Mouse0.67010166

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level6.59518852
2MP0004043_abnormal_pH_regulation5.19745284
3MP0003656_abnormal_erythrocyte_physiolo5.07809389
4MP0005397_hematopoietic_system_phenotyp3.82572336
5MP0001545_abnormal_hematopoietic_system3.82572336
6MP0000920_abnormal_myelination3.67859701
7MP0008995_early_reproductive_senescence3.05341846
8MP0005464_abnormal_platelet_physiology2.81410282
9MP0005636_abnormal_mineral_homeostasis2.43144539
10MP0009379_abnormal_foot_pigmentation2.18156398
11MP0003195_calcinosis2.17526037
12MP0003136_yellow_coat_color2.08617094
13MP0001905_abnormal_dopamine_level2.06703680
14MP0005058_abnormal_lysosome_morphology2.04789756
15MP0001529_abnormal_vocalization2.02260375
16MP0009278_abnormal_bone_marrow1.95970425
17MP0003123_paternal_imprinting1.95653456
18MP0005379_endocrine/exocrine_gland_phen1.93471777
19MP0000013_abnormal_adipose_tissue1.93300092
20MP0001485_abnormal_pinna_reflex1.91797248
21MP0003186_abnormal_redox_activity1.90455999
22MP0004885_abnormal_endolymph1.86331371
23MP0006054_spinal_hemorrhage1.79692916
24MP0006036_abnormal_mitochondrial_physio1.74777538
25MP0004742_abnormal_vestibular_system1.67802775
26MP0003183_abnormal_peptide_metabolism1.67619267
27MP0003172_abnormal_lysosome_physiology1.65814789
28MP0003303_peritoneal_inflammation1.62695418
29MP0003878_abnormal_ear_physiology1.61898402
30MP0005377_hearing/vestibular/ear_phenot1.61898402
31MP0001661_extended_life_span1.59418459
32MP0003950_abnormal_plasma_membrane1.58799868
33MP0000462_abnormal_digestive_system1.55773884
34MP0000015_abnormal_ear_pigmentation1.55588890
35MP0005171_absent_coat_pigmentation1.55044463
36MP0005409_darkened_coat_color1.54002540
37MP0009643_abnormal_urine_homeostasis1.53684584
38MP0005075_abnormal_melanosome_morpholog1.53619032
39MP0008438_abnormal_cutaneous_collagen1.52096009
40MP0002163_abnormal_gland_morphology1.48986533
41MP0000749_muscle_degeneration1.48963669
42MP0006035_abnormal_mitochondrial_morpho1.48599999
43MP0003786_premature_aging1.46553551
44MP0005408_hypopigmentation1.46510098
45MP0003806_abnormal_nucleotide_metabolis1.46299861
46MP0002938_white_spotting1.46020971
47MP0009840_abnormal_foam_cell1.45534502
48MP0003329_amyloid_beta_deposits1.42370135
49MP0008260_abnormal_autophagy1.41034984
50MP0003191_abnormal_cellular_cholesterol1.38962581
51MP0002229_neurodegeneration1.38729734
52MP0003634_abnormal_glial_cell1.36206737
53MP0001765_abnormal_ion_homeostasis1.34154359
54MP0008004_abnormal_stomach_pH1.33932037
55MP0004142_abnormal_muscle_tone1.33102557
56MP0009333_abnormal_splenocyte_physiolog1.32985762
57MP0001756_abnormal_urination1.32315383
58MP0010386_abnormal_urinary_bladder1.31950848
59MP0002295_abnormal_pulmonary_circulatio1.31620500
60MP0000613_abnormal_salivary_gland1.30168354
61MP0003315_abnormal_perineum_morphology1.29262264
62MP0000003_abnormal_adipose_tissue1.24468788
63MP0003111_abnormal_nucleus_morphology1.21895581
64MP0002822_catalepsy1.20894516
65MP0002837_dystrophic_cardiac_calcinosis1.19758184
66MP0006072_abnormal_retinal_apoptosis1.19700153
67MP0002398_abnormal_bone_marrow1.12783212
68MP0005410_abnormal_fertilization1.11630495
69MP0002272_abnormal_nervous_system1.11286690
70MP0000689_abnormal_spleen_morphology1.09992407
71MP0003690_abnormal_glial_cell1.07510302
72MP0008058_abnormal_DNA_repair1.07484098
73MP0000566_synostosis1.06368024
74MP0005332_abnormal_amino_acid1.06065869
75MP0002722_abnormal_immune_system1.04862697
76MP0001944_abnormal_pancreas_morphology1.04245499
77MP0000747_muscle_weakness1.04024320
78MP0003436_decreased_susceptibility_to1.03355568
79MP0001764_abnormal_homeostasis1.00714082
80MP0000678_abnormal_parathyroid_gland0.98847060
81MP0005503_abnormal_tendon_morphology0.97188070
82MP0005025_abnormal_response_to0.96248314
83MP0004270_analgesia0.95064783
84MP0001542_abnormal_bone_strength0.94788618
85MP0002095_abnormal_skin_pigmentation0.94450187
86MP0000343_altered_response_to0.93153701
87MP0002429_abnormal_blood_cell0.92472974
88MP0000230_abnormal_systemic_arterial0.92195730
89MP0000609_abnormal_liver_physiology0.90795207
90MP0000313_abnormal_cell_death0.90675178
91MP0004272_abnormal_basement_membrane0.90501126
92MP0005220_abnormal_exocrine_pancreas0.90354082
93MP0000465_gastrointestinal_hemorrhage0.88457979
94MP0009765_abnormal_xenobiotic_induced0.87372062
95MP0003937_abnormal_limbs/digits/tail_de0.85167480
96MP0002132_abnormal_respiratory_system0.85031336
97MP0001664_abnormal_digestion0.84251912
98MP0003011_delayed_dark_adaptation0.83795770
99MP0004957_abnormal_blastocyst_morpholog0.83576623
100MP0005451_abnormal_body_composition0.83405209
101MP0003122_maternal_imprinting0.81919611
102MP0009931_abnormal_skin_appearance0.81854739
103MP0000762_abnormal_tongue_morphology0.80809707
104MP0003718_maternal_effect0.80614017
105MP0003724_increased_susceptibility_to0.80341455
106MP0003693_abnormal_embryo_hatching0.79736233
107MP0009764_decreased_sensitivity_to0.79675930
108MP0005551_abnormal_eye_electrophysiolog0.77912498
109MP0003866_abnormal_defecation0.77154758
110MP0001963_abnormal_hearing_physiology0.76987253
111MP0008932_abnormal_embryonic_tissue0.76944609
112MP0000631_abnormal_neuroendocrine_gland0.76755138
113MP0000598_abnormal_liver_morphology0.76463567
114MP0004145_abnormal_muscle_electrophysio0.76103643
115MP0001299_abnormal_eye_distance/0.75926821
116MP0002419_abnormal_innate_immunity0.75870534
117MP0002396_abnormal_hematopoietic_system0.74637054
118MP0002638_abnormal_pupillary_reflex0.74371309
119MP0003879_abnormal_hair_cell0.73254363
120MP0008872_abnormal_physiological_respon0.72839274
121MP0005646_abnormal_pituitary_gland0.72651531
122MP0003959_abnormal_lean_body0.72078373
123MP0001346_abnormal_lacrimal_gland0.71178658
124MP0004808_abnormal_hematopoietic_stem0.71105716
125MP0002693_abnormal_pancreas_physiology0.69989417
126MP0004381_abnormal_hair_follicle0.69913242
127MP0002405_respiratory_system_inflammati0.68792799
128MP0002019_abnormal_tumor_incidence0.68758704
129MP0005501_abnormal_skin_physiology0.68112374
130MP0005375_adipose_tissue_phenotype0.67393152
131MP0005084_abnormal_gallbladder_morpholo0.67331968
132MP0008775_abnormal_heart_ventricle0.67135848
133MP0009697_abnormal_copulation0.66990177
134MP0001727_abnormal_embryo_implantation0.66255136
135MP0002653_abnormal_ependyma_morphology0.66165159
136MP0000778_abnormal_nervous_system0.65891263
137MP0009763_increased_sensitivity_to0.65730084
138MP0000681_abnormal_thyroid_gland0.64752769
139MP0001958_emphysema0.64458107
140MP0005319_abnormal_enzyme/_coenzyme0.64128302
141MP0000372_irregular_coat_pigmentation0.62344356
142MP0001986_abnormal_taste_sensitivity0.61143336
143MP0009250_abnormal_appendicular_skeleto0.60495268
144MP0001819_abnormal_immune_cell0.60421317
145MP0000026_abnormal_inner_ear0.60262865
146MP0002420_abnormal_adaptive_immunity0.60116734
147MP0008469_abnormal_protein_level0.60072381
148MP0005083_abnormal_biliary_tract0.59829203
149MP0004036_abnormal_muscle_relaxation0.59828765
150MP0005195_abnormal_posterior_eye0.59203195
151MP0000639_abnormal_adrenal_gland0.58482690
152MP0001663_abnormal_digestive_system0.57834337
153MP0005388_respiratory_system_phenotype0.57273920
154MP0002133_abnormal_respiratory_system0.57273920
155MP0000703_abnormal_thymus_morphology0.56959518
156MP0000716_abnormal_immune_system0.56612616
157MP0002210_abnormal_sex_determination0.56287699
158MP0001929_abnormal_gametogenesis0.56181794
159MP0000358_abnormal_cell_content/0.55195122
160MP0001145_abnormal_male_reproductive0.54542022
161MP0003632_abnormal_nervous_system0.54368223
162MP0002160_abnormal_reproductive_system0.54235654
163MP0000653_abnormal_sex_gland0.53724554
164MP0002148_abnormal_hypersensitivity_rea0.53540794
165MP0009642_abnormal_blood_homeostasis0.52938650
166MP0003077_abnormal_cell_cycle0.52476093
167MP0005000_abnormal_immune_tolerance0.52034275
168MP0003698_abnormal_male_reproductive0.51438421
169MP0005584_abnormal_enzyme/coenzyme_acti0.51026675
170MP0009785_altered_susceptibility_to0.48760298

Predicted human phenotypes

RankGene SetZ-score
1Abnormal hemoglobin (HP:0011902)7.94569113
2Abnormality of the heme biosynthetic pathway (HP:0010472)7.24517423
3Hypochromic microcytic anemia (HP:0004840)7.12730949
4Abnormality of reticulocytes (HP:0004312)5.44060846
5Microcytic anemia (HP:0001935)5.40424433
6Hypochromic anemia (HP:0001931)4.61416686
7Prolonged bleeding time (HP:0003010)4.50332070
8Pallor (HP:0000980)4.40983209
9Cholelithiasis (HP:0001081)4.35351581
10Polycythemia (HP:0001901)4.28445454
11Petechiae (HP:0000967)4.25436225
12Diaphragmatic weakness (HP:0009113)3.98692221
13Acute necrotizing encephalopathy (HP:0006965)3.91806271
14Cholecystitis (HP:0001082)3.84569803
15Abnormal gallbladder physiology (HP:0012438)3.84569803
16Cerebral hypomyelination (HP:0006808)3.82697955
17Abnormal number of erythroid precursors (HP:0012131)3.70972297
18Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.63595005
19Abnormality of cells of the erythroid lineage (HP:0012130)3.55928184
20Mitochondrial inheritance (HP:0001427)3.53279059
21Ileus (HP:0002595)3.48317874
22Abnormal mitochondria in muscle tissue (HP:0008316)3.43217630
23Hepatocellular necrosis (HP:0001404)3.38523443
24Acute encephalopathy (HP:0006846)3.37421989
25Abnormality of iron homeostasis (HP:0011031)3.31579616
26Hypokalemic alkalosis (HP:0001949)3.31022501
273-Methylglutaconic aciduria (HP:0003535)3.27808584
28Gonadal dysgenesis (HP:0000133)3.26621065
29Hypomagnesemia (HP:0002917)3.24568973
30Abnormality of magnesium homeostasis (HP:0004921)3.16488655
31Increased circulating renin level (HP:0000848)3.15010889
32Increased serum ferritin (HP:0003281)3.14439766
33Paralysis (HP:0003470)3.12325676
34Progressive macrocephaly (HP:0004481)3.10375301
35Metabolic alkalosis (HP:0200114)3.09988840
36Renal Fanconi syndrome (HP:0001994)3.07789792
37Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.07344554
38Hepatic necrosis (HP:0002605)3.06669274
39Degeneration of the lateral corticospinal tracts (HP:0002314)3.01768752
40Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.01768752
41Abnormality of transition element cation homeostasis (HP:0011030)2.96592201
42Aplasia/Hypoplasia of the sacrum (HP:0008517)2.92955753
43Abnormality of the gallbladder (HP:0005264)2.92898313
44Neurofibrillary tangles (HP:0002185)2.90667577
45Generalized aminoaciduria (HP:0002909)2.89569935
46Sensory axonal neuropathy (HP:0003390)2.88651811
47Epistaxis (HP:0000421)2.86032741
48Leukodystrophy (HP:0002415)2.84438393
49Increased muscle lipid content (HP:0009058)2.83614030
50Poikilocytosis (HP:0004447)2.77366316
51Nausea (HP:0002018)2.74938490
52Increased CSF lactate (HP:0002490)2.74851679
53Aplasia/hypoplasia of the uterus (HP:0008684)2.73862488
54Hyperthyroidism (HP:0000836)2.69217140
55Parakeratosis (HP:0001036)2.68485310
56Abnormal platelet function (HP:0011869)2.65734796
57Impaired platelet aggregation (HP:0003540)2.65734796
58Hypertensive crisis (HP:0100735)2.65107807
59Male infertility (HP:0003251)2.63855034
60Toxemia of pregnancy (HP:0100603)2.62029338
61Glycosuria (HP:0003076)2.60322407
62Abnormality of urine glucose concentration (HP:0011016)2.60322407
63Split foot (HP:0001839)2.58005339
64Increased hepatocellular lipid droplets (HP:0006565)2.54065023
65Albinism (HP:0001022)2.53210880
66Macrocytic anemia (HP:0001972)2.51372957
67Testicular neoplasm (HP:0010788)2.50002042
68Abnormality of renal resorption (HP:0011038)2.47808738
69Congenital ichthyosiform erythroderma (HP:0007431)2.45972449
70Respiratory failure (HP:0002878)2.45322662
71Abnormality of renin-angiotensin system (HP:0000847)2.41550262
72Purpura (HP:0000979)2.36630020
73Lipid accumulation in hepatocytes (HP:0006561)2.36513741
74Renal salt wasting (HP:0000127)2.35701212
75Gingival bleeding (HP:0000225)2.35063098
76Hyperphosphaturia (HP:0003109)2.33414738
77Cerebral palsy (HP:0100021)2.33221238
78Hypoplasia of the uterus (HP:0000013)2.32737518
79Acanthocytosis (HP:0001927)2.27514220
80Severe visual impairment (HP:0001141)2.27006703
81Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.25469883
82Abnormal drinking behavior (HP:0030082)2.24526971
83Polydipsia (HP:0001959)2.24526971
84Polyuria (HP:0000103)2.23771722
85Spastic paraparesis (HP:0002313)2.22410338
86Cutaneous photosensitivity (HP:0000992)2.22084800
87Truncus arteriosus (HP:0001660)2.20229275
88Abnormality of chloride homeostasis (HP:0011422)2.18452608
89Respiratory difficulties (HP:0002880)2.17359683
90Hyponatremia (HP:0002902)2.15415396
91Abnormality of glycolysis (HP:0004366)2.15074731
92Increased serum pyruvate (HP:0003542)2.15074731
93CNS hypomyelination (HP:0003429)2.14129431
94Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.12886111
95Osteomalacia (HP:0002749)2.12858978
96Decreased activity of mitochondrial respiratory chain (HP:0008972)2.12559158
97Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.12559158
98Hypokalemia (HP:0002900)2.12271359
99Peripheral hypomyelination (HP:0007182)2.10694149
100Dysostosis multiplex (HP:0000943)2.10378399
101Abnormal urine output (HP:0012590)2.09929957
102Hyperaldosteronism (HP:0000859)2.09626450
103Gastrointestinal infarctions (HP:0005244)2.09146810
104Obstructive lung disease (HP:0006536)2.06725570
105Chronic obstructive pulmonary disease (HP:0006510)2.06725570
106Abnormal auditory evoked potentials (HP:0006958)2.04637812
107Abnormal urine phosphate concentration (HP:0012599)2.03176571
108Hyperactive renin-angiotensin system (HP:0000841)2.02984670
109Delayed epiphyseal ossification (HP:0002663)2.02323724
110Exertional dyspnea (HP:0002875)2.00922461
111Type I transferrin isoform profile (HP:0003642)2.00079910
112Abnormality of dental color (HP:0011073)1.98571583
113Aplasia/Hypoplasia of the earlobes (HP:0009906)1.98244865
114Hepatocellular carcinoma (HP:0001402)1.96442642
115Increased intramyocellular lipid droplets (HP:0012240)1.95714366
116Abnormal gallbladder morphology (HP:0012437)1.90942690
117Abnormality of renal excretion (HP:0011036)1.90626603
118CNS demyelination (HP:0007305)1.89801695
119Rectal prolapse (HP:0002035)1.88825025
120Hypoparathyroidism (HP:0000829)1.87517340
121Abnormality of macrophages (HP:0004311)1.86888487
122Abnormality of aromatic amino acid family metabolism (HP:0004338)1.86715940
123Abnormality of sodium homeostasis (HP:0010931)1.86353772
124Cerebral edema (HP:0002181)1.86197283
125Reticulocytosis (HP:0001923)1.86026552
126Abnormal platelet volume (HP:0011876)1.85843764
127Increased IgM level (HP:0003496)1.84542805
128Increased serum lactate (HP:0002151)1.83886386
129Congenital sensorineural hearing impairment (HP:0008527)1.83079342
130Seborrheic dermatitis (HP:0001051)1.82772127
131Progressive neurologic deterioration (HP:0002344)1.82438497
132Hyperparathyroidism (HP:0000843)1.81291855
133Symptomatic seizures (HP:0011145)1.80959325
134Delusions (HP:0000746)1.80144423
135Hyperbilirubinemia (HP:0002904)1.79898486
136Abnormality of liposaccharide metabolism (HP:0010968)1.79626283
137Abnormality of glycosphingolipid metabolism (HP:0004343)1.79626283
138Abnormality of glycolipid metabolism (HP:0010969)1.79626283
139Abnormal pupillary function (HP:0007686)1.79510598
140Pustule (HP:0200039)1.78067650
141Cortical visual impairment (HP:0100704)1.76652868
142Menorrhagia (HP:0000132)1.76141453
143Hypothermia (HP:0002045)1.75690221
144Carpal bone hypoplasia (HP:0001498)1.74373108
145Vacuolated lymphocytes (HP:0001922)1.74148535
146Optic disc pallor (HP:0000543)1.73521131
147Renal tubular dysfunction (HP:0000124)1.73127069
148Microvesicular hepatic steatosis (HP:0001414)1.72948817
149Hyperglycinemia (HP:0002154)1.71078447
150Gastrointestinal dysmotility (HP:0002579)1.67028028
151Recurrent abscess formation (HP:0002722)1.66381152
152Increased mean platelet volume (HP:0011877)1.64620858
153Short middle phalanx of the 5th finger (HP:0004220)1.64239102
154Abnormality of homocysteine metabolism (HP:0010919)1.63149667
155Homocystinuria (HP:0002156)1.63149667
156Neoplasm of head and neck (HP:0012288)1.62476588
157Esophageal neoplasm (HP:0100751)1.62476588
158Splenomegaly (HP:0001744)1.61513993
159Abnormality of the fingertips (HP:0001211)1.58645242
160Male pseudohermaphroditism (HP:0000037)1.52927569
161Nonimmune hydrops fetalis (HP:0001790)1.50896013
162Degeneration of anterior horn cells (HP:0002398)1.50775536
163Abnormality of the anterior horn cell (HP:0006802)1.50775536
164Lactic acidosis (HP:0003128)1.50716210

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.32459836
2WNK44.28582622
3OXSR14.17871339
4TLK13.52747489
5NME23.28548492
6MAP2K33.00601988
7TAOK22.85456162
8MAPKAPK52.58729091
9STK162.57751095
10VRK22.54773686
11PBK2.35760194
12GRK62.32054078
13BUB12.28246920
14CDK192.26588014
15EIF2AK12.18288095
16TNK22.14866322
17MAPK152.06267449
18RIPK42.05781977
19FES2.05259316
20TAOK11.91468399
21BMX1.90165288
22PRPF4B1.86190804
23MAP2K21.86036714
24ERN11.85758666
25MET1.84922186
26PKN11.84039726
27WNK31.74589588
28TESK21.74177605
29EPHB11.70563128
30MST41.65312087
31INSRR1.62047386
32NTRK11.60509761
33BRAF1.59189587
34BCKDK1.43867427
35WNK11.42795807
36MAP3K31.42596161
37MAP4K21.38700518
38NME11.38080705
39PIM11.36658787
40SMG11.31109079
41SCYL21.30565218
42BCR1.26635981
43VRK11.26581237
44MAP4K11.22802462
45CAMK2B1.22566852
46MUSK1.21506779
47UHMK11.21130619
48CSNK1G31.19918406
49IRAK21.14065644
50KDR1.13780574
51CAMK2D1.12118672
52DYRK21.11083087
53MAP3K11.10742846
54LIMK11.09976193
55MATK1.08033717
56CCNB11.06728397
57TNIK1.03305826
58PNCK1.02767353
59IKBKB1.02326762
60CSNK1G11.02233815
61NEK60.98795022
62BTK0.98126619
63CSNK1A1L0.96986708
64ABL20.95235373
65MAP3K80.94609767
66CLK10.92783272
67ARAF0.91521347
68RPS6KA50.90117912
69LRRK20.88348856
70RAF10.86014558
71IRAK40.85580907
72NUAK10.85553273
73SGK4940.84066018
74SGK2230.84066018
75EIF2AK30.84059744
76CAMK2G0.81466482
77ZAP700.80960411
78PINK10.79599009
79ROCK20.79466438
80DAPK30.78950705
81GRK70.78391859
82SYK0.77996823
83AURKA0.75215561
84HIPK20.74934243
85MAP3K50.73944639
86MAP3K120.73922881
87MYLK0.73653856
88CASK0.70325522
89TYK20.69629108
90RPS6KL10.68955506
91RPS6KC10.68955506
92ZAK0.67339340
93MARK30.64513226
94OBSCN0.64313312
95IRAK10.62550081
96IRAK30.61845612
97MKNK20.61591991
98CSNK1G20.60660126
99MKNK10.59287923
100PLK30.58740585
101PRKD20.57945211
102JAK30.57662620
103PLK40.57218516
104RPS6KA60.57136060
105JAK20.56971247
106BRSK20.56700642
107MARK20.56616438
108BMPR1B0.56338966
109TEC0.56127591
110DAPK10.54503985
111RPS6KA40.54222052
112LYN0.53359808
113DYRK30.53036265
114PASK0.52973046
115PRKD10.51962626
116ICK0.51333523
117HCK0.50499569
118BLK0.48202689
119PAK10.47992530
120ILK0.47634378
121CDK140.46525735
122GSK3A0.46283900
123MAPK110.46193795
124PDPK10.45785192
125MAP2K40.45501759
126PLK10.45381178
127CSNK1A10.44036208
128WEE10.43415093
129MAPK120.43347264
130PRKCE0.41241159
131PRKCQ0.39751010
132TBK10.39642480
133PTK2B0.38950145
134MAP2K60.38330193
135PRKAA20.38316136
136KSR20.37893249
137DYRK1B0.37657884
138MAP2K10.37187704
139IKBKE0.37166696
140TAOK30.36603932
141MAP3K20.36426556
142STK40.36223656
143SRPK10.35843342
144CDK11A0.35768964
145BRSK10.35337872
146TRPM70.34845252
147FGR0.34710486
148AKT30.34110706
149CDK150.32989687
150PIM20.32932647
151CSNK2A20.31042785
152TIE10.30334771
153CAMK2A0.30291963
154CDK50.29689896
155PRKACA0.28814149
156MAP3K110.28674241
157CSNK2A10.28512814
158GRK10.26090465
159CDK180.25117169
160MAPKAPK20.24465800
161PAK20.23169490

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030605.01275680
2Oxidative phosphorylation_Homo sapiens_hsa001903.81719704
3Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008603.44387475
4Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.25131346
5Parkinsons disease_Homo sapiens_hsa050123.23869325
6Ribosome_Homo sapiens_hsa030103.12325324
7Sulfur metabolism_Homo sapiens_hsa009202.81049514
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.66195967
9Maturity onset diabetes of the young_Homo sapiens_hsa049502.61395769
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.56758880
11Fatty acid elongation_Homo sapiens_hsa000622.46614724
12Steroid biosynthesis_Homo sapiens_hsa001002.33578395
13Malaria_Homo sapiens_hsa051442.30248432
14RNA polymerase_Homo sapiens_hsa030202.28025374
15Alzheimers disease_Homo sapiens_hsa050102.27704393
16Huntingtons disease_Homo sapiens_hsa050162.08621937
17Vitamin B6 metabolism_Homo sapiens_hsa007502.05893396
18One carbon pool by folate_Homo sapiens_hsa006702.02112646
19Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.01005044
20Sphingolipid metabolism_Homo sapiens_hsa006001.99232649
21Proteasome_Homo sapiens_hsa030501.95794056
22Ether lipid metabolism_Homo sapiens_hsa005651.89429553
23SNARE interactions in vesicular transport_Homo sapiens_hsa041301.80090582
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.79408492
25Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.69308235
26Linoleic acid metabolism_Homo sapiens_hsa005911.64151262
27Folate biosynthesis_Homo sapiens_hsa007901.62182813
28Glutathione metabolism_Homo sapiens_hsa004801.61748755
29Base excision repair_Homo sapiens_hsa034101.58237711
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.58001647
31Arachidonic acid metabolism_Homo sapiens_hsa005901.55276369
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.46897764
33Histidine metabolism_Homo sapiens_hsa003401.41572480
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.40736598
35Collecting duct acid secretion_Homo sapiens_hsa049661.35392938
36Carbon metabolism_Homo sapiens_hsa012001.24728266
37Cardiac muscle contraction_Homo sapiens_hsa042601.23770341
38Vibrio cholerae infection_Homo sapiens_hsa051101.20132601
39Homologous recombination_Homo sapiens_hsa034401.17782345
40Arginine and proline metabolism_Homo sapiens_hsa003301.15698148
41Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.14791188
42Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.14084692
43Acute myeloid leukemia_Homo sapiens_hsa052211.13945646
44Pyrimidine metabolism_Homo sapiens_hsa002401.13842594
45Lysosome_Homo sapiens_hsa041421.13482078
46Other glycan degradation_Homo sapiens_hsa005111.11571097
47Basal transcription factors_Homo sapiens_hsa030221.07305352
48African trypanosomiasis_Homo sapiens_hsa051431.07269201
49Sulfur relay system_Homo sapiens_hsa041221.05427501
50Hematopoietic cell lineage_Homo sapiens_hsa046400.99650591
51Metabolic pathways_Homo sapiens_hsa011000.97891780
522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.97577546
53Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.92776137
54Regulation of autophagy_Homo sapiens_hsa041400.90245157
55Purine metabolism_Homo sapiens_hsa002300.87549523
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.87148326
57Biosynthesis of amino acids_Homo sapiens_hsa012300.85600812
58Galactose metabolism_Homo sapiens_hsa000520.84788200
59Nucleotide excision repair_Homo sapiens_hsa034200.83489822
60DNA replication_Homo sapiens_hsa030300.81659276
61Fanconi anemia pathway_Homo sapiens_hsa034600.80519783
62Fructose and mannose metabolism_Homo sapiens_hsa000510.77631597
63Butanoate metabolism_Homo sapiens_hsa006500.77389699
64Non-small cell lung cancer_Homo sapiens_hsa052230.74970838
65Adipocytokine signaling pathway_Homo sapiens_hsa049200.73720138
66Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.72632050
67Non-homologous end-joining_Homo sapiens_hsa034500.71040821
68Fatty acid metabolism_Homo sapiens_hsa012120.70459912
69Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70401868
70N-Glycan biosynthesis_Homo sapiens_hsa005100.67942595
71Thyroid cancer_Homo sapiens_hsa052160.67731453
72Bladder cancer_Homo sapiens_hsa052190.65369182
73Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.63683017
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.61958510
75Nitrogen metabolism_Homo sapiens_hsa009100.61116131
76Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.59416675
77Cysteine and methionine metabolism_Homo sapiens_hsa002700.58731067
78Mineral absorption_Homo sapiens_hsa049780.56023080
79Vitamin digestion and absorption_Homo sapiens_hsa049770.55617429
80Herpes simplex infection_Homo sapiens_hsa051680.54563795
81Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54190099
82Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54040008
83Protein digestion and absorption_Homo sapiens_hsa049740.53951166
84Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.53457090
85Tyrosine metabolism_Homo sapiens_hsa003500.52302627
86Platelet activation_Homo sapiens_hsa046110.52132743
87Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.50834239
88Spliceosome_Homo sapiens_hsa030400.50148470
89Mismatch repair_Homo sapiens_hsa034300.48159936
90Peroxisome_Homo sapiens_hsa041460.48147957
91Cell cycle_Homo sapiens_hsa041100.47574246
92Pyruvate metabolism_Homo sapiens_hsa006200.46582942
93Pancreatic cancer_Homo sapiens_hsa052120.45761744
94Glycosaminoglycan degradation_Homo sapiens_hsa005310.45641901
95Alcoholism_Homo sapiens_hsa050340.45601118
96Primary immunodeficiency_Homo sapiens_hsa053400.44072400
97RNA transport_Homo sapiens_hsa030130.43455329
98ECM-receptor interaction_Homo sapiens_hsa045120.43285384
99Systemic lupus erythematosus_Homo sapiens_hsa053220.41603927
100Propanoate metabolism_Homo sapiens_hsa006400.40693140
101Chronic myeloid leukemia_Homo sapiens_hsa052200.40148942
102Glycerophospholipid metabolism_Homo sapiens_hsa005640.39537983
103Leishmaniasis_Homo sapiens_hsa051400.39422843
104Epstein-Barr virus infection_Homo sapiens_hsa051690.39382457
105Apoptosis_Homo sapiens_hsa042100.39104403
106Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38366940
107Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.38339248
108Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.37586359
109Pancreatic secretion_Homo sapiens_hsa049720.36916114
110Drug metabolism - other enzymes_Homo sapiens_hsa009830.35762928
111Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35419487
112Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.34021377
113Selenocompound metabolism_Homo sapiens_hsa004500.33555049
114Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.32761265
115Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.32182803
116Tight junction_Homo sapiens_hsa045300.31487107
117Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.30840999
118AMPK signaling pathway_Homo sapiens_hsa041520.29824338
119Chemical carcinogenesis_Homo sapiens_hsa052040.28402911
120Staphylococcus aureus infection_Homo sapiens_hsa051500.28371844
121Jak-STAT signaling pathway_Homo sapiens_hsa046300.28264733
122beta-Alanine metabolism_Homo sapiens_hsa004100.27650288
123Steroid hormone biosynthesis_Homo sapiens_hsa001400.26993761
124ABC transporters_Homo sapiens_hsa020100.26206399
125Rheumatoid arthritis_Homo sapiens_hsa053230.25967568
126Serotonergic synapse_Homo sapiens_hsa047260.25236925
127Vascular smooth muscle contraction_Homo sapiens_hsa042700.25134011
128Thyroid hormone synthesis_Homo sapiens_hsa049180.22220868
129Cyanoamino acid metabolism_Homo sapiens_hsa004600.20635364
130Renal cell carcinoma_Homo sapiens_hsa052110.20436038
131Pentose phosphate pathway_Homo sapiens_hsa000300.18738777
132Cocaine addiction_Homo sapiens_hsa050300.18475205
133Autoimmune thyroid disease_Homo sapiens_hsa053200.18195996
134Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.17282362
135RNA degradation_Homo sapiens_hsa030180.16882560
136Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.16301129
137Phagosome_Homo sapiens_hsa041450.16223789
138Sphingolipid signaling pathway_Homo sapiens_hsa040710.16177276
139Hedgehog signaling pathway_Homo sapiens_hsa043400.16076435
140Insulin secretion_Homo sapiens_hsa049110.14818272
141Phenylalanine metabolism_Homo sapiens_hsa003600.14238747
142Fat digestion and absorption_Homo sapiens_hsa049750.14194220
143Prostate cancer_Homo sapiens_hsa052150.12633211

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