ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal large subunit biogenesis (GO:0042273)	6.23228378
2	ribosomal small subunit biogenesis (GO:0042274)	5.34230707
3	ribosomal small subunit assembly (GO:0000028)	5.20953678
4	viral transcription (GO:0019083)	5.06366464
5	translational termination (GO:0006415)	4.96872969
6	ribonucleoprotein complex biogenesis (GO:0022613)	4.43830811
7	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.36061462
8	protoporphyrinogen IX metabolic process (GO:0046501)	4.34319563
9	translational elongation (GO:0006414)	4.26372836
10	heme biosynthetic process (GO:0006783)	4.25807197
11	cotranslational protein targeting to membrane (GO:0006613)	4.24869548
12	protein targeting to ER (GO:0045047)	4.23447136
13	telomere maintenance via semi-conservative replication (GO:0032201)	4.15794588
14	nucleobase-containing small molecule interconversion (GO:0015949)	4.10503596
15	protein localization to endoplasmic reticulum (GO:0070972)	4.09273935
16	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.08029902
17	DNA strand elongation involved in DNA replication (GO:0006271)	4.04104996
18	ribosome assembly (GO:0042255)	3.95523875
19	oxidative phosphorylation (GO:0006119)	3.94846117
20	DNA unwinding involved in DNA replication (GO:0006268)	3.94198131
21	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.93563022
22	regulation of mitochondrial translation (GO:0070129)	3.90615816
23	DNA strand elongation (GO:0022616)	3.89594430
24	maturation of SSU-rRNA (GO:0030490)	3.88489061
25	cellular protein complex disassembly (GO:0043624)	3.85572201
26	negative regulation of erythrocyte differentiation (GO:0045647)	3.82693326
27	translational initiation (GO:0006413)	3.79905459
28	tRNA methylation (GO:0030488)	3.79345251
29	viral life cycle (GO:0019058)	3.78846562
30	protoporphyrinogen IX biosynthetic process (GO:0006782)	3.76982695
31	heme metabolic process (GO:0042168)	3.73505858
32	porphyrin-containing compound biosynthetic process (GO:0006779)	3.72275244
33	purine nucleobase biosynthetic process (GO:0009113)	3.71350540
34	IMP biosynthetic process (GO:0006188)	3.60615591
35	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.57821372
36	respiratory chain complex IV assembly (GO:0008535)	3.56711389
37	cellular component biogenesis (GO:0044085)	3.55760721
38	DNA replication initiation (GO:0006270)	3.54960198
39	DNA topological change (GO:0006265)	3.54931059
40	ribosome biogenesis (GO:0042254)	3.53914527
41	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.53470819
42	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.51664519
43	definitive hemopoiesis (GO:0060216)	3.49562803
44	translation (GO:0006412)	3.42645576
45	telomere maintenance via recombination (GO:0000722)	3.39483485
46	mitochondrial RNA metabolic process (GO:0000959)	3.36020689
47	valine metabolic process (GO:0006573)	3.34845005
48	formation of translation preinitiation complex (GO:0001731)	3.33439884
49	tetrapyrrole biosynthetic process (GO:0033014)	3.32155740
50	positive regulation of odontogenesis (GO:0042482)	3.31669184
51	nucleobase biosynthetic process (GO:0046112)	3.30658060
52	protein complex disassembly (GO:0043241)	3.29580792
53	regulation of mitotic spindle organization (GO:0060236)	3.28010821
54	regulation of translational fidelity (GO:0006450)	3.26314315
55	IMP metabolic process (GO:0046040)	3.25736036
56	rRNA processing (GO:0006364)	3.25045370
57	pseudouridine synthesis (GO:0001522)	3.23721960
58	porphyrin-containing compound metabolic process (GO:0006778)	3.19384259
59	mitotic recombination (GO:0006312)	3.17283856
60	gonadal mesoderm development (GO:0007506)	3.15418177
61	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	3.14512014
62	regulation of cytokine production involved in inflammatory response (GO:1900015)	3.13365047
63	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.13189629
64	ATP synthesis coupled proton transport (GO:0015986)	3.13189629
65	macromolecular complex disassembly (GO:0032984)	3.11434569
66	folic acid-containing compound biosynthetic process (GO:0009396)	3.11109837
67	DNA damage response, detection of DNA damage (GO:0042769)	3.09904600
68	proline biosynthetic process (GO:0006561)	3.09576771
69	proteasome assembly (GO:0043248)	3.06268748
70	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	3.06081742
71	rRNA metabolic process (GO:0016072)	3.05207877
72	cytochrome complex assembly (GO:0017004)	3.04732906
73	sister chromatid segregation (GO:0000819)	3.02382284
74	deoxyribose phosphate biosynthetic process (GO:0046385)	2.99946083
75	2-deoxyribonucleotide biosynthetic process (GO:0009265)	2.99946083
76	aerobic respiration (GO:0009060)	2.98589269
77	pigment biosynthetic process (GO:0046148)	2.97750068
78	protein targeting to membrane (GO:0006612)	2.96730013
79	granulocyte differentiation (GO:0030851)	2.92898207
80	telomere maintenance via telomere lengthening (GO:0010833)	2.88714161
81	folic acid metabolic process (GO:0046655)	2.86344009
82	viral mRNA export from host cell nucleus (GO:0046784)	2.86193666
83	protein targeting to mitochondrion (GO:0006626)	2.81038655
84	UV protection (GO:0009650)	2.77029603
85	respiratory electron transport chain (GO:0022904)	2.76666044
86	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.75489660
87	guanosine-containing compound biosynthetic process (GO:1901070)	2.71939362
88	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.71086714
89	deoxyribonucleotide biosynthetic process (GO:0009263)	2.70937991
90	electron transport chain (GO:0022900)	2.68352260
91	oxaloacetate metabolic process (GO:0006107)	2.68178321
92	protein maturation by protein folding (GO:0022417)	2.62842067
93	response to thyroid hormone (GO:0097066)	2.61575612
94	mRNA catabolic process (GO:0006402)	2.61313512
95	meiotic chromosome segregation (GO:0045132)	2.59684635
96	AMP metabolic process (GO:0046033)	2.59392923
97	kinetochore organization (GO:0051383)	2.58520237
98	nucleotide-excision repair, DNA gap filling (GO:0006297)	2.58233573
99	negative regulation of mRNA splicing, via spliceosome (GO:0048025)	2.57898295
100	purine nucleobase metabolic process (GO:0006144)	2.57763328

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	8.52984841
2	MYC_18555785_ChIP-Seq_MESCs_Mouse	4.83148078
3	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	4.28092298
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.91751970
5	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.43300365
6	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.34852214
7	GATA1_22025678_ChIP-Seq_K562_Human	3.26376842
8	MYC_18358816_ChIP-ChIP_MESCs_Mouse	3.20919038
9	CREB1_15753290_ChIP-ChIP_HEK293T_Human	3.12894429
10	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.12829657
11	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.96921719
12	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.79144110
13	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.78984485
14	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.67045411
15	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.59910332
16	ZNF263_19887448_ChIP-Seq_K562_Human	2.57846737
17	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.54820570
18	DCP1A_22483619_ChIP-Seq_HELA_Human	2.47666075
19	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.42141759
20	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.23753312
21	TTF2_22483619_ChIP-Seq_HELA_Human	2.21853290
22	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	2.17542902
23	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.12965784
24	XRN2_22483619_ChIP-Seq_HELA_Human	2.11133983
25	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.09520643
26	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.08452010
27	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.99413655
28	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.98684655
29	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.98045639
30	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.98016986
31	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.90083492
32	FOXP3_21729870_ChIP-Seq_TREG_Human	1.86353138
33	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.83765719
34	ELK1_19687146_ChIP-ChIP_HELA_Human	1.76964241
35	AR_21909140_ChIP-Seq_LNCAP_Human	1.70129467
36	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.67148691
37	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.60791020
38	SCL_19346495_ChIP-Seq_HPC-7_Human	1.60056354
39	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.59252020
40	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.58598619
41	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.57686629
42	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.57405713
43	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.56396169
44	GABP_19822575_ChIP-Seq_HepG2_Human	1.55458702
45	VDR_23849224_ChIP-Seq_CD4+_Human	1.53983360
46	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.51686511
47	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.50237228
48	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.48589046
49	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.48530557
50	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.44454951
51	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.42065348
52	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.40619471
53	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.38719270
54	KDM5A_27292631_Chip-Seq_BREAST_Human	1.32780995
55	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.31526589
56	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.29123791
57	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.28795224
58	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.28493844
59	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.27390767
60	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.25001675
61	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.20113000
62	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.19524192
63	MYC_18940864_ChIP-ChIP_HL60_Human	1.19405953
64	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.18073457
65	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.15588495
66	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.15011442
67	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.14072611
68	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.11879201
69	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.10464488
70	VDR_21846776_ChIP-Seq_THP-1_Human	1.10359257
71	TFEB_21752829_ChIP-Seq_HELA_Human	1.10111261
72	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	1.09879827
73	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.09792365
74	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.08273762
75	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.07943940
76	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.06935211
77	NCOR1_26117541_ChIP-Seq_K562_Human	1.06304717
78	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.06068339
79	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	1.05845965
80	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.01303396
81	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	0.98708834
82	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.97983721
83	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.96443383
84	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	0.95601044
85	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	0.95100516
86	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	0.92000650
87	RARG_19884340_ChIP-ChIP_MEFs_Mouse	0.91543002
88	GATA1_19941826_ChIP-Seq_K562_Human	0.90349958
89	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.89618574
90	TBX5_21415370_ChIP-Seq_HL-1_Mouse	0.88730435
91	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.87958785
92	TRIM28_19339689_ChIP-ChIP_MESCs_Mouse	0.87655439
93	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	0.85690255
94	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.84898584
95	MYC_22102868_ChIP-Seq_BL_Human	0.82907418
96	STAT3_1855785_ChIP-Seq_MESCs_Mouse	0.82290207
97	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	0.81481274
98	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.80323962
99	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.78067638
100	CIITA_25753668_ChIP-Seq_RAJI_Human	0.75918523

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003806_abnormal_nucleotide_metabolis	4.35195489
2	MP0004147_increased_porphyrin_level	4.07838417
3	MP0008438_abnormal_cutaneous_collagen	3.38034194
4	MP0010094_abnormal_chromosome_stability	3.03791914
5	MP0002877_abnormal_melanocyte_morpholog	2.86343482
6	MP0008058_abnormal_DNA_repair	2.84185475
7	MP0005503_abnormal_tendon_morphology	2.84020876
8	MP0003656_abnormal_erythrocyte_physiolo	2.74535023
9	MP0002396_abnormal_hematopoietic_system	2.55633381
10	MP0003950_abnormal_plasma_membrane	2.52971306
11	MP0003111_abnormal_nucleus_morphology	2.50713510
12	MP0001545_abnormal_hematopoietic_system	2.43018236
13	MP0005397_hematopoietic_system_phenotyp	2.43018236
14	MP0003186_abnormal_redox_activity	2.41681204
15	MP0004957_abnormal_blastocyst_morpholog	2.30606777
16	MP0003077_abnormal_cell_cycle	2.14250003
17	MP0003693_abnormal_embryo_hatching	1.95397564
18	MP0006036_abnormal_mitochondrial_physio	1.92376971
19	MP0005623_abnormal_meninges_morphology	1.89856522
20	MP0001661_extended_life_span	1.88774596
21	MP0005670_abnormal_white_adipose	1.87826536
22	MP0003786_premature_aging	1.84970814
23	MP0008932_abnormal_embryonic_tissue	1.84085577
24	MP0000465_gastrointestinal_hemorrhage	1.78910422
25	MP0005058_abnormal_lysosome_morphology	1.76132454
26	MP0000372_irregular_coat_pigmentation	1.74757298
27	MP0008007_abnormal_cellular_replicative	1.74137481
28	MP0004808_abnormal_hematopoietic_stem	1.73737731
29	MP0008057_abnormal_DNA_replication	1.68162276
30	MP0005171_absent_coat_pigmentation	1.63666917
31	MP0006138_congestive_heart_failure	1.58397878
32	MP0003718_maternal_effect	1.49833310
33	MP0002938_white_spotting	1.44091231
34	MP0005275_abnormal_skin_tensile	1.43257677
35	MP0003828_pulmonary_edema	1.35135293
36	MP0000350_abnormal_cell_proliferation	1.27989227
37	MP0005330_cardiomyopathy	1.27395896
38	MP0008995_early_reproductive_senescence	1.26640743
39	MP0003279_aneurysm	1.26417357
40	MP0004272_abnormal_basement_membrane	1.23937847
41	MP0001542_abnormal_bone_strength	1.21497871
42	MP0002132_abnormal_respiratory_system	1.20873480
43	MP0009697_abnormal_copulation	1.20748578
44	MP0003136_yellow_coat_color	1.18060129
45	MP0005266_abnormal_metabolism	1.11238789
46	MP0009379_abnormal_foot_pigmentation	1.09587339
47	MP0000358_abnormal_cell_content/	1.09400255
48	MP0010368_abnormal_lymphatic_system	1.08965696
49	MP0005410_abnormal_fertilization	1.08779065
50	MP0002108_abnormal_muscle_morphology	1.07671221
51	MP0000747_muscle_weakness	1.05856881
52	MP0009250_abnormal_appendicular_skeleto	1.04739617
53	MP0003705_abnormal_hypodermis_morpholog	1.04675114
54	MP0005083_abnormal_biliary_tract	1.03929815
55	MP0001730_embryonic_growth_arrest	1.01911670
56	MP0000681_abnormal_thyroid_gland	1.00924935
57	MP0001697_abnormal_embryo_size	0.99908855
58	MP0005464_abnormal_platelet_physiology	0.98758395
59	MP0005636_abnormal_mineral_homeostasis	0.97822749
60	MP0002019_abnormal_tumor_incidence	0.95054584
61	MP0002080_prenatal_lethality	0.93576058
62	MP0005508_abnormal_skeleton_morphology	0.92501738
63	MP0006276_abnormal_autonomic_nervous	0.91601952
64	MP0009384_cardiac_valve_regurgitation	0.91543281
65	MP0002234_abnormal_pharynx_morphology	0.90817695
66	MP0005174_abnormal_tail_pigmentation	0.90311693
67	MP0000015_abnormal_ear_pigmentation	0.89371267
68	MP0000749_muscle_degeneration	0.89315671
69	MP0000313_abnormal_cell_death	0.88712706
70	MP0000013_abnormal_adipose_tissue	0.87712670
71	MP0003984_embryonic_growth_retardation	0.86975927
72	MP0010307_abnormal_tumor_latency	0.86775450
73	MP0005408_hypopigmentation	0.86665308
74	MP0004233_abnormal_muscle_weight	0.83859909
75	MP0002295_abnormal_pulmonary_circulatio	0.83326328
76	MP0000759_abnormal_skeletal_muscle	0.83281947
77	MP0009278_abnormal_bone_marrow	0.83125222
78	MP0002088_abnormal_embryonic_growth/wei	0.80814018
79	MP0002095_abnormal_skin_pigmentation	0.80646131
80	MP0008775_abnormal_heart_ventricle	0.79829530
81	MP0000343_altered_response_to	0.78140852
82	MP0010630_abnormal_cardiac_muscle	0.77962723
83	MP0001672_abnormal_embryogenesis/_devel	0.77697278
84	MP0005380_embryogenesis_phenotype	0.77697278
85	MP0001881_abnormal_mammary_gland	0.77591174
86	MP0002160_abnormal_reproductive_system	0.76790471
87	MP0004145_abnormal_muscle_electrophysio	0.76696753
88	MP0005165_increased_susceptibility_to	0.76147354
89	MP0001764_abnormal_homeostasis	0.75864221
90	MP0002269_muscular_atrophy	0.74866820
91	MP0004084_abnormal_cardiac_muscle	0.73572226
92	MP0004087_abnormal_muscle_fiber	0.71566444
93	MP0005647_abnormal_sex_gland	0.70974460
94	MP0002086_abnormal_extraembryonic_tissu	0.67801667
95	MP0005376_homeostasis/metabolism_phenot	0.64979726
96	MP0002127_abnormal_cardiovascular_syste	0.63362418
97	MP0005385_cardiovascular_system_phenoty	0.62533119
98	MP0001544_abnormal_cardiovascular_syste	0.62533119
99	MP0000230_abnormal_systemic_arterial	0.62310359
100	MP0003172_abnormal_lysosome_physiology	0.61783327

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of cells of the erythroid lineage (HP:0012130)	4.93214598
2	Abnormal number of erythroid precursors (HP:0012131)	4.38721918
3	Abnormality of the heme biosynthetic pathway (HP:0010472)	4.22199459
4	Reduced antithrombin III activity (HP:0001976)	4.04787475
5	Short middle phalanx of the 5th finger (HP:0004220)	3.45724710
6	Nonimmune hydrops fetalis (HP:0001790)	3.29194653
7	Reticulocytosis (HP:0001923)	3.28543610
8	Pallor (HP:0000980)	3.28191617
9	Abnormality of reticulocytes (HP:0004312)	3.21953412
10	Protrusio acetabuli (HP:0003179)	3.21056294
11	Petechiae (HP:0000967)	3.19824792
12	Polycythemia (HP:0001901)	3.17378649
13	Progressive muscle weakness (HP:0003323)	3.13917477
14	Macrocytic anemia (HP:0001972)	3.09141121
15	Reticulocytopenia (HP:0001896)	3.08040772
16	Abnormal hemoglobin (HP:0011902)	3.04928494
17	Hyperthyroidism (HP:0000836)	2.99392506
18	Abnormality of the tricuspid valve (HP:0001702)	2.99350361
19	Increased CSF lactate (HP:0002490)	2.96736373
20	Abnormal mitochondria in muscle tissue (HP:0008316)	2.91763756
21	Acute encephalopathy (HP:0006846)	2.90932789
22	Hypertensive crisis (HP:0100735)	2.90160069
23	Respiratory difficulties (HP:0002880)	2.89785035
24	Premature rupture of membranes (HP:0001788)	2.89731404
25	Hepatocellular necrosis (HP:0001404)	2.86701820
26	Microvesicular hepatic steatosis (HP:0001414)	2.82946209
27	Abnormal gallbladder physiology (HP:0012438)	2.75569968
28	Cholecystitis (HP:0001082)	2.75569968
29	Acute necrotizing encephalopathy (HP:0006965)	2.70530138
30	Testicular atrophy (HP:0000029)	2.65567230
31	Hepatic necrosis (HP:0002605)	2.63844996
32	Mitochondrial inheritance (HP:0001427)	2.61238896
33	Esophageal neoplasm (HP:0100751)	2.51553853
34	Neoplasm of head and neck (HP:0012288)	2.51553853
35	Vertebral compression fractures (HP:0002953)	2.50872687
36	Abnormality of the intrinsic pathway (HP:0010989)	2.49636785
37	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.48867677
38	Abnormal protein N-linked glycosylation (HP:0012347)	2.48867677
39	Abnormal protein glycosylation (HP:0012346)	2.48867677
40	Abnormal glycosylation (HP:0012345)	2.48867677
41	Redundant skin (HP:0001582)	2.39736585
42	Aplastic anemia (HP:0001915)	2.37478238
43	Cerebral edema (HP:0002181)	2.37055432
44	Cholelithiasis (HP:0001081)	2.36836696
45	Chromsome breakage (HP:0040012)	2.34770360
46	Increased intramyocellular lipid droplets (HP:0012240)	2.34451149
47	Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)	2.30665581
48	Paralysis (HP:0003470)	2.28721914
49	Increased serum lactate (HP:0002151)	2.26040543
50	Increased muscle lipid content (HP:0009058)	2.25333436
51	Deformed tarsal bones (HP:0008119)	2.24731771
52	Lactic acidosis (HP:0003128)	2.23747050
53	Thoracolumbar scoliosis (HP:0002944)	2.23655774
54	Elbow flexion contracture (HP:0002987)	2.21779440
55	Calcaneovalgus deformity (HP:0001848)	2.19826800
56	Abnormality of the fetal cardiovascular system (HP:0010948)	2.19476121
57	Abnormal umbilical cord blood vessels (HP:0011403)	2.19476121
58	Single umbilical artery (HP:0001195)	2.19476121
59	Abnormality of the umbilical cord (HP:0010881)	2.18774462
60	Hypoplastic left heart (HP:0004383)	2.15524897
61	Prolonged bleeding time (HP:0003010)	2.15370352
62	Type I transferrin isoform profile (HP:0003642)	2.14411697
63	Increased hepatocellular lipid droplets (HP:0006565)	2.11480414
64	Venous insufficiency (HP:0005293)	2.10648367
65	Lipid accumulation in hepatocytes (HP:0006561)	2.10422995
66	Thrombocytosis (HP:0001894)	2.09595164
67	Patchy hypopigmentation of hair (HP:0011365)	2.07628663
68	Birth length less than 3rd percentile (HP:0003561)	2.07238854
69	Venous abnormality (HP:0002624)	2.04497096
70	Atelectasis (HP:0100750)	2.03900580
71	Progressive macrocephaly (HP:0004481)	2.01194806
72	Increased mean platelet volume (HP:0011877)	1.99298995
73	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.99142925
74	Ileus (HP:0002595)	1.98895418
75	Abnormal pupillary function (HP:0007686)	1.98515640
76	Hyperalaninemia (HP:0003348)	1.96945680
77	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.96945680
78	Abnormality of alanine metabolism (HP:0010916)	1.96945680
79	Self-mutilation (HP:0000742)	1.96351028
80	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.95420800
81	Abnormal gallbladder morphology (HP:0012437)	1.94790206
82	Pancytopenia (HP:0001876)	1.94346166
83	Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)	1.93240527
84	Aortic aneurysm (HP:0004942)	1.92713434
85	Breech presentation (HP:0001623)	1.92049117
86	Slender long bone (HP:0003100)	1.91839121
87	Exercise intolerance (HP:0003546)	1.91294944
88	Sensory axonal neuropathy (HP:0003390)	1.91289345
89	Hypoparathyroidism (HP:0000829)	1.90734806
90	Increased serum ferritin (HP:0003281)	1.90668405
91	Myelodysplasia (HP:0002863)	1.89993517
92	Truncus arteriosus (HP:0001660)	1.89692905
93	Albinism (HP:0001022)	1.88955328
94	White forelock (HP:0002211)	1.88670564
95	Abnormality of the acetabulum (HP:0003170)	1.85852235
96	Seborrheic dermatitis (HP:0001051)	1.85445456
97	Abnormality of the columella (HP:0009929)	1.84920508
98	Respiratory failure (HP:0002878)	1.84255513
99	Rough bone trabeculation (HP:0100670)	1.84189420
100	Progressive microcephaly (HP:0000253)	1.84006579

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	LATS1	4.54365055
2	INSRR	4.50015559
3	NME2	3.87518612
4	PDK2	3.08482227
5	NUAK1	2.94448721
6	CDC7	2.89902198
7	BUB1	2.89306458
8	EIF2AK1	2.63738977
9	MYLK	2.45604481
10	PBK	2.44148679
11	VRK2	2.30053858
12	RPS6KB2	2.24827273
13	PIM2	2.20899271
14	EIF2AK3	1.85083366
15	PAK2	1.81879352
16	SCYL2	1.80509302
17	CHEK2	1.73732496
18	MAPKAPK5	1.67339000
19	TTK	1.67043624
20	WEE1	1.58162077
21	KDR	1.51791167
22	EEF2K	1.51205247
23	CCNB1	1.50411243
24	MAPKAPK3	1.44111400
25	NEK1	1.43862508
26	SRPK1	1.41639610
27	MAP4K2	1.36029846
28	MKNK1	1.25322458
29	BCKDK	1.25237523
30	ABL2	1.20834107
31	ZAK	1.19084679
32	TAOK2	1.16865980
33	STK3	1.12310109
34	ILK	1.05341055
35	RAF1	1.04289765
36	NME1	0.98885952
37	CLK1	0.96525523
38	BRSK2	0.96459184
39	TIE1	0.93171434
40	ATR	0.90658885
41	CDK8	0.89618954
42	PLK4	0.88707657
43	NEK2	0.87766934
44	EIF2AK2	0.85887704
45	DAPK1	0.83997703
46	PLK3	0.83796554
47	CHEK1	0.83078655
48	PLK1	0.80759469
49	LATS2	0.80255114
50	DAPK3	0.79204157
51	AURKB	0.79023098
52	PIK3CG	0.78780604
53	CDK7	0.78621456
54	KIT	0.77140890
55	TEC	0.77106394
56	AURKA	0.73311819
57	FLT3	0.73172213
58	CDK4	0.70272525
59	TRPM7	0.68955635
60	PAK1	0.68562531
61	TESK1	0.66706646
62	RPS6KA5	0.63247809
63	MAP2K3	0.63166355
64	BMPR2	0.62952453
65	VRK1	0.60010226
66	CSNK2A2	0.58510875
67	PINK1	0.56567868
68	JAK3	0.55645848
69	TGFBR2	0.54881840
70	TTN	0.54672306
71	MAP2K2	0.54291846
72	MAP2K1	0.54149821
73	PIM1	0.53505994
74	ERN1	0.52614968
75	STK16	0.48551737
76	GRK5	0.47579893
77	CSNK2A1	0.46129142
78	ATM	0.43691302
79	DMPK	0.43632854
80	MAPK4	0.43036551
81	ERBB4	0.41904385
82	BRSK1	0.41181442
83	RPS6KC1	0.40493541
84	RPS6KL1	0.40493541
85	CDK2	0.40084501
86	CDK3	0.39303603
87	PRKG2	0.39233435
88	MAP3K8	0.38843457
89	CDK1	0.37634306
90	MAP3K12	0.36904281
91	RPS6KA4	0.35950564
92	TSSK6	0.35434066
93	ADRBK1	0.34806829
94	CDK12	0.34279038
95	MST1R	0.33548681
96	RPS6KA6	0.32885278
97	NEK9	0.32707902
98	PAK4	0.32657831
99	AKT2	0.31936855
100	BMX	0.30532022

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.83087029
2	DNA replication_Homo sapiens_hsa03030	4.66961502
3	Mismatch repair_Homo sapiens_hsa03430	3.47313075
4	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	3.17662408
5	Base excision repair_Homo sapiens_hsa03410	2.70010398
6	Sulfur relay system_Homo sapiens_hsa04122	2.69980552
7	Homologous recombination_Homo sapiens_hsa03440	2.56804438
8	One carbon pool by folate_Homo sapiens_hsa00670	2.39110335
9	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.38858751
10	Nucleotide excision repair_Homo sapiens_hsa03420	2.26057464
11	Pyrimidine metabolism_Homo sapiens_hsa00240	2.11730666
12	Spliceosome_Homo sapiens_hsa03040	2.07817692
13	Oxidative phosphorylation_Homo sapiens_hsa00190	1.94825401
14	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.94460174
15	Parkinsons disease_Homo sapiens_hsa05012	1.90214320
16	RNA polymerase_Homo sapiens_hsa03020	1.89474494
17	Proteasome_Homo sapiens_hsa03050	1.87517651
18	Purine metabolism_Homo sapiens_hsa00230	1.86480612
19	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.82803936
20	Fanconi anemia pathway_Homo sapiens_hsa03460	1.78422928
21	Fatty acid elongation_Homo sapiens_hsa00062	1.75865756
22	Cell cycle_Homo sapiens_hsa04110	1.71695633
23	Pyruvate metabolism_Homo sapiens_hsa00620	1.66190441
24	Glutathione metabolism_Homo sapiens_hsa00480	1.63822018
25	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.62131134
26	RNA transport_Homo sapiens_hsa03013	1.61684114
27	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.61323938
28	Folate biosynthesis_Homo sapiens_hsa00790	1.46638501
29	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.45322416
30	Huntingtons disease_Homo sapiens_hsa05016	1.37242649
31	Carbon metabolism_Homo sapiens_hsa01200	1.37222295
32	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.36501452
33	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.30340554
34	Selenocompound metabolism_Homo sapiens_hsa00450	1.30110664
35	Non-homologous end-joining_Homo sapiens_hsa03450	1.29924973
36	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.26396425
37	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.21895171
38	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.18857470
39	Sulfur metabolism_Homo sapiens_hsa00920	1.15552682
40	Propanoate metabolism_Homo sapiens_hsa00640	1.13199622
41	Pentose phosphate pathway_Homo sapiens_hsa00030	1.12430517
42	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.11055196
43	Alzheimers disease_Homo sapiens_hsa05010	1.05479945
44	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.00622609
45	Tyrosine metabolism_Homo sapiens_hsa00350	0.98542787
46	Bladder cancer_Homo sapiens_hsa05219	0.95780841
47	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.94636736
48	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.93974764
49	Protein export_Homo sapiens_hsa03060	0.92589154
50	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.81847290
51	Basal transcription factors_Homo sapiens_hsa03022	0.79642067
52	Nitrogen metabolism_Homo sapiens_hsa00910	0.79255836
53	ECM-receptor interaction_Homo sapiens_hsa04512	0.79195203
54	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.76408012
55	Metabolic pathways_Homo sapiens_hsa01100	0.75317041
56	Fatty acid metabolism_Homo sapiens_hsa01212	0.74069831
57	RNA degradation_Homo sapiens_hsa03018	0.70941489
58	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.68816590
59	Cardiac muscle contraction_Homo sapiens_hsa04260	0.62729095
60	mRNA surveillance pathway_Homo sapiens_hsa03015	0.59636960
61	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.55235037
62	Butanoate metabolism_Homo sapiens_hsa00650	0.54401321
63	Small cell lung cancer_Homo sapiens_hsa05222	0.54025709
64	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.54008162
65	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.50811005
66	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.50328859
67	Tryptophan metabolism_Homo sapiens_hsa00380	0.50140168
68	Phenylalanine metabolism_Homo sapiens_hsa00360	0.46920857
69	Melanoma_Homo sapiens_hsa05218	0.44389303
70	p53 signaling pathway_Homo sapiens_hsa04115	0.42671943
71	Renin-angiotensin system_Homo sapiens_hsa04614	0.41073336
72	Peroxisome_Homo sapiens_hsa04146	0.41005910
73	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.36018421
74	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.35772117
75	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.34349410
76	Fatty acid degradation_Homo sapiens_hsa00071	0.34125623
77	beta-Alanine metabolism_Homo sapiens_hsa00410	0.33535714
78	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.32926490
79	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.32067314
80	Other glycan degradation_Homo sapiens_hsa00511	0.31759135
81	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.31523035
82	Pancreatic cancer_Homo sapiens_hsa05212	0.31455128
83	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.29924839
84	Platelet activation_Homo sapiens_hsa04611	0.28559482
85	Oocyte meiosis_Homo sapiens_hsa04114	0.24507038
86	HTLV-I infection_Homo sapiens_hsa05166	0.23670910
87	Galactose metabolism_Homo sapiens_hsa00052	0.21402304
88	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.19960688
89	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.19109959
90	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.17908237
91	Olfactory transduction_Homo sapiens_hsa04740	0.15941542
92	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.15412396
93	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.15054640
94	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.14965742
95	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.14391044
96	Arginine and proline metabolism_Homo sapiens_hsa00330	0.13667893
97	Arginine biosynthesis_Homo sapiens_hsa00220	0.13075868
98	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.12541118
99	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.11763232
100	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.11662975

SMIM10

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »