SMIM10L1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine deoxyribonucleotide catabolic process (GO:0009223)5.73936088
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.23921025
3base-excision repair, AP site formation (GO:0006285)4.87577550
4pyrimidine nucleotide catabolic process (GO:0006244)4.86056002
5protein complex biogenesis (GO:0070271)4.82397749
6ATP synthesis coupled proton transport (GO:0015986)4.77922225
7energy coupled proton transport, down electrochemical gradient (GO:0015985)4.77922225
8protein neddylation (GO:0045116)4.71114344
9chaperone-mediated protein transport (GO:0072321)4.66019104
10mitochondrial respiratory chain complex assembly (GO:0033108)4.63859055
11mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.45304154
12mitochondrial respiratory chain complex I assembly (GO:0032981)4.45304154
13NADH dehydrogenase complex assembly (GO:0010257)4.45304154
14pyrimidine deoxyribonucleotide metabolic process (GO:0009219)4.34987352
15establishment of protein localization to mitochondrial membrane (GO:0090151)4.31248414
16ribosomal small subunit assembly (GO:0000028)4.27362163
17regulation of mitochondrial translation (GO:0070129)4.17289796
18viral transcription (GO:0019083)4.16019206
19respiratory electron transport chain (GO:0022904)4.11616375
20ribosomal small subunit biogenesis (GO:0042274)4.09324839
21translational termination (GO:0006415)4.07513217
22electron transport chain (GO:0022900)4.06960956
23epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.96663716
24negative regulation of response to food (GO:0032096)3.88748399
25negative regulation of appetite (GO:0032099)3.88748399
26aggressive behavior (GO:0002118)3.86939181
27deoxyribonucleotide catabolic process (GO:0009264)3.82162159
28SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.77722283
29cytochrome complex assembly (GO:0017004)3.77585305
30cotranslational protein targeting to membrane (GO:0006613)3.73521856
31protein targeting to ER (GO:0045047)3.68738729
32deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.65762841
33proteasome assembly (GO:0043248)3.64153113
34nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.61895284
35synaptic vesicle exocytosis (GO:0016079)3.59391204
36neurotransmitter-gated ion channel clustering (GO:0072578)3.58959032
37negative regulation of heart rate (GO:0010459)3.58111471
38respiratory chain complex IV assembly (GO:0008535)3.57570787
39regulation of synaptic vesicle exocytosis (GO:2000300)3.56787087
40translational elongation (GO:0006414)3.54639342
41oxidative phosphorylation (GO:0006119)3.53318928
42establishment of protein localization to endoplasmic reticulum (GO:0072599)3.52317926
43transcription elongation from RNA polymerase III promoter (GO:0006385)3.51304385
44termination of RNA polymerase III transcription (GO:0006386)3.51304385
45deoxyribose phosphate catabolic process (GO:0046386)3.51199348
46protein localization to endoplasmic reticulum (GO:0070972)3.51043963
47exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.49247764
48vocalization behavior (GO:0071625)3.45178992
49glutamate secretion (GO:0014047)3.41331154
50ubiquinone biosynthetic process (GO:0006744)3.39416370
51DNA deamination (GO:0045006)3.38690666
52regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.38048352
53substrate-independent telencephalic tangential migration (GO:0021826)3.37620537
54substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.37620537
55ribosomal large subunit biogenesis (GO:0042273)3.36150917
56neuronal action potential propagation (GO:0019227)3.35808596
57ubiquinone metabolic process (GO:0006743)3.34933502
58succinate metabolic process (GO:0006105)3.31815013
59replication fork processing (GO:0031297)3.27017254
60presynaptic membrane assembly (GO:0097105)3.26230574
61regulation of short-term neuronal synaptic plasticity (GO:0048172)3.25761362
62synaptic vesicle docking involved in exocytosis (GO:0016081)3.25081844
63pseudouridine synthesis (GO:0001522)3.19784450
64water-soluble vitamin biosynthetic process (GO:0042364)3.19651118
65viral life cycle (GO:0019058)3.19579097
66regulation of synaptic vesicle transport (GO:1902803)3.19405800
67protein targeting to mitochondrion (GO:0006626)3.14860444
68negative regulation of dendrite morphogenesis (GO:0050774)3.13385048
69intraciliary transport (GO:0042073)3.12771304
70cellular protein complex disassembly (GO:0043624)3.12323286
71maturation of SSU-rRNA (GO:0030490)3.11550101
72cellular component biogenesis (GO:0044085)3.08288858
73translation (GO:0006412)3.07875024
74membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.06907871
75synaptic vesicle maturation (GO:0016188)3.06394931
76neurotransmitter secretion (GO:0007269)3.04359907
77establishment of protein localization to mitochondrion (GO:0072655)3.02662324
782-deoxyribonucleotide metabolic process (GO:0009394)3.02016972
79nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.01351710
80tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.99818069
81RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.99818069
82translational initiation (GO:0006413)2.98800121
83regulation of cilium movement (GO:0003352)2.98581253
84negative regulation of synaptic transmission, GABAergic (GO:0032229)2.97895797
85behavioral response to nicotine (GO:0035095)2.96636139
86regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.91457779
87kinetochore assembly (GO:0051382)2.91285269
88positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.89827254
89presynaptic membrane organization (GO:0097090)2.89335206
90deoxyribose phosphate metabolic process (GO:0019692)2.87361085
91pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.85888451
92maturation of 5.8S rRNA (GO:0000460)2.85110406
93neuron cell-cell adhesion (GO:0007158)2.85011885
94protein localization to mitochondrion (GO:0070585)2.84806292
95regulation of glutamate receptor signaling pathway (GO:1900449)2.83204731
96protein deneddylation (GO:0000338)2.82021080
97purine nucleotide salvage (GO:0032261)2.78854398
98postsynaptic membrane organization (GO:0001941)2.78272126
99NADH metabolic process (GO:0006734)2.77438718
100purine nucleoside triphosphate biosynthetic process (GO:0009145)2.77210826
101ATP biosynthetic process (GO:0006754)2.75998379
102intracellular protein transmembrane import (GO:0044743)2.75949100
103purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.75377147
104DNA-dependent DNA replication (GO:0006261)2.74440230
105negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.73888003
106GTP biosynthetic process (GO:0006183)2.73409914
107tricarboxylic acid cycle (GO:0006099)2.73376320
108maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.71621110
109somite development (GO:0061053)2.71392254
110detection of calcium ion (GO:0005513)2.71320027
111CTP metabolic process (GO:0046036)2.70124404
112CTP biosynthetic process (GO:0006241)2.70124404
113hydrogen ion transmembrane transport (GO:1902600)2.69561039
114chromatin remodeling at centromere (GO:0031055)2.68335033
115pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.67863344
116epithelial cilium movement (GO:0003351)2.67735065
117protein localization to synapse (GO:0035418)2.67041275
118cullin deneddylation (GO:0010388)2.66441027
119kinetochore organization (GO:0051383)2.66174466
120regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.66049170
121oxaloacetate metabolic process (GO:0006107)2.65797429
122quinone biosynthetic process (GO:1901663)2.65611794
123deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.65380504
124protein complex disassembly (GO:0043241)2.65186391
125positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.64960541
126deoxyribonucleotide metabolic process (GO:0009262)2.64861853
127gamma-aminobutyric acid transport (GO:0015812)2.64809200
128nucleotide-excision repair, DNA gap filling (GO:0006297)2.64095433
129DNA damage response, detection of DNA damage (GO:0042769)2.63265462
130positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.60616665
131locomotory exploration behavior (GO:0035641)2.60150256
132positive regulation of muscle hypertrophy (GO:0014742)2.56086522
133positive regulation of cardiac muscle hypertrophy (GO:0010613)2.56086522
134neuron-neuron synaptic transmission (GO:0007270)2.55203440
135positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.53332573
136female mating behavior (GO:0060180)2.49691315
137regulation of synapse structural plasticity (GO:0051823)2.48367398
138inositol phosphate catabolic process (GO:0071545)2.46465322
139regulation of cell communication by electrical coupling (GO:0010649)2.46090801
140gamma-aminobutyric acid signaling pathway (GO:0007214)2.43041500
141activation of protein kinase A activity (GO:0034199)2.42620211
142neurotransmitter transport (GO:0006836)2.42446216
143long-term synaptic potentiation (GO:0060291)2.41676169
144regulation of female receptivity (GO:0045924)2.41288457
145positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.41034312
146regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.40707730
147regulation of neuronal synaptic plasticity (GO:0048168)2.38116074
148regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.37895485
149negative regulation of dendrite development (GO:2000171)2.36847796
150regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.35799990
151ER overload response (GO:0006983)2.33336389
152regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.33320255
153negative regulation of cation channel activity (GO:2001258)2.32327783
154regulation of long-term neuronal synaptic plasticity (GO:0048169)2.32071331
155synaptic transmission, glutamatergic (GO:0035249)2.32043513
156ATP hydrolysis coupled proton transport (GO:0015991)2.31176594
157energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.31176594
158erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.30915265
159L-phenylalanine catabolic process (GO:0006559)2.30915265
160regulation of synaptic transmission, glutamatergic (GO:0051966)2.30514413
161striatum development (GO:0021756)2.30302717
162cerebellar granule cell differentiation (GO:0021707)2.29752199
163coenzyme catabolic process (GO:0009109)2.29408963
164regulation of acyl-CoA biosynthetic process (GO:0050812)2.29094602
165regulation of neurotransmitter levels (GO:0001505)2.26832672
166negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.26398132
167positive regulation of synaptic transmission, GABAergic (GO:0032230)2.26157947
168regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.24958110
169regulation of excitatory postsynaptic membrane potential (GO:0060079)2.24663017
170cellular ketone body metabolic process (GO:0046950)2.24545502
171cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.23698483
172regulation of vesicle fusion (GO:0031338)2.21689169
173transferrin transport (GO:0033572)2.21432247
174regulation of neurotransmitter secretion (GO:0046928)2.20615265
175glutamate receptor signaling pathway (GO:0007215)2.19767541
176ionotropic glutamate receptor signaling pathway (GO:0035235)2.19606061
177ferric iron transport (GO:0015682)2.18697290
178trivalent inorganic cation transport (GO:0072512)2.18697290
179mechanosensory behavior (GO:0007638)2.16744825
180membrane depolarization during action potential (GO:0086010)2.16423393
181regulation of voltage-gated calcium channel activity (GO:1901385)2.14872244
182behavioral response to cocaine (GO:0048148)2.14074274
183regulation of postsynaptic membrane potential (GO:0060078)2.13572877
184positive regulation of mitochondrial fission (GO:0090141)2.13032506
185mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.12687621
186proline transport (GO:0015824)2.11974103
187cellular potassium ion homeostasis (GO:0030007)2.10415092
188auditory behavior (GO:0031223)2.10147509
189regulation of synaptic transmission, GABAergic (GO:0032228)2.09893649
190regulation of cofactor metabolic process (GO:0051193)2.09218797
191regulation of coenzyme metabolic process (GO:0051196)2.09218797
192positive regulation of membrane potential (GO:0045838)2.09160082
193innervation (GO:0060384)2.08180252
194calcium ion-dependent exocytosis (GO:0017156)2.08102191
195L-phenylalanine metabolic process (GO:0006558)2.07726423
196erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.07726423
197regulation of neurotransmitter transport (GO:0051588)2.07619432
198startle response (GO:0001964)2.07580795
199synapse assembly (GO:0007416)2.06147435

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.63688401
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.17209713
3GBX2_23144817_ChIP-Seq_PC3_Human3.78248030
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.64125170
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.46360473
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.30141626
7EZH2_22144423_ChIP-Seq_EOC_Human3.27399829
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.12354979
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.98495928
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.78878518
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.63216937
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.61155829
13MYC_18555785_ChIP-Seq_MESCs_Mouse2.60834649
14SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.57012260
15ELK1_19687146_ChIP-ChIP_HELA_Human2.52568960
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.46094875
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.43062258
18VDR_23849224_ChIP-Seq_CD4+_Human2.42710112
19TAF15_26573619_Chip-Seq_HEK293_Human2.41008257
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.38191075
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.36362719
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.32724493
23SRF_21415370_ChIP-Seq_HL-1_Mouse2.32105768
24PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.29961318
25TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.22894716
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.19751773
27SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.17382090
28JARID2_20064375_ChIP-Seq_MESCs_Mouse2.13402290
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.06709156
30SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.03982753
31SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.03438791
32RNF2_18974828_ChIP-Seq_MESCs_Mouse2.03379147
33EZH2_18974828_ChIP-Seq_MESCs_Mouse2.03379147
34MTF2_20144788_ChIP-Seq_MESCs_Mouse2.02727318
35SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.01825940
36JARID2_20075857_ChIP-Seq_MESCs_Mouse2.00859254
37EED_16625203_ChIP-ChIP_MESCs_Mouse1.96653405
38MYC_18940864_ChIP-ChIP_HL60_Human1.92820494
39THAP11_20581084_ChIP-Seq_MESCs_Mouse1.92437848
40FOXP3_21729870_ChIP-Seq_TREG_Human1.91634834
41MYC_18358816_ChIP-ChIP_MESCs_Mouse1.90390207
42POU3F2_20337985_ChIP-ChIP_501MEL_Human1.87530453
43EZH2_27304074_Chip-Seq_ESCs_Mouse1.86604727
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.83025990
45ZFP57_27257070_Chip-Seq_ESCs_Mouse1.82289396
46GABP_19822575_ChIP-Seq_HepG2_Human1.82170059
47PIAS1_25552417_ChIP-Seq_VCAP_Human1.79645452
48P300_19829295_ChIP-Seq_ESCs_Human1.77467274
49SMAD4_21799915_ChIP-Seq_A2780_Human1.76537575
50REST_21632747_ChIP-Seq_MESCs_Mouse1.73817583
51TTF2_22483619_ChIP-Seq_HELA_Human1.72899777
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.70130206
53POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.69974349
54PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68364104
55MYC_19030024_ChIP-ChIP_MESCs_Mouse1.66904432
56EWS_26573619_Chip-Seq_HEK293_Human1.65532718
57AR_21572438_ChIP-Seq_LNCaP_Human1.64925883
58FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.64117259
59PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.63929563
60E2F4_17652178_ChIP-ChIP_JURKAT_Human1.61569747
61EZH2_27294783_Chip-Seq_ESCs_Mouse1.60649665
62SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.59212541
63SUZ12_27294783_Chip-Seq_ESCs_Mouse1.57273117
64RNF2_27304074_Chip-Seq_ESCs_Mouse1.56039742
65ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.55328925
66OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.54160373
67NR3C1_23031785_ChIP-Seq_PC12_Mouse1.53972880
68XRN2_22483619_ChIP-Seq_HELA_Human1.53755766
69E2F1_18555785_ChIP-Seq_MESCs_Mouse1.50816489
70NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.50799572
71NRF2_20460467_ChIP-Seq_MEFs_Mouse1.50799572
72TOP2B_26459242_ChIP-Seq_MCF-7_Human1.50648117
73ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.48790352
74IRF1_19129219_ChIP-ChIP_H3396_Human1.47923567
75AR_25329375_ChIP-Seq_VCAP_Human1.47205590
76CDX2_19796622_ChIP-Seq_MESCs_Mouse1.44368881
77DROSHA_22980978_ChIP-Seq_HELA_Human1.43498286
78PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.42344204
79SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42102812
80GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41187848
81REST_18959480_ChIP-ChIP_MESCs_Mouse1.40166042
82AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.39802454
83DCP1A_22483619_ChIP-Seq_HELA_Human1.39558837
84NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.39147985
85SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.37487217
86ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.37356493
87RARB_27405468_Chip-Seq_BRAIN_Mouse1.36534432
88SMAD3_21741376_ChIP-Seq_EPCs_Human1.34826071
89CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.34242567
90BMI1_23680149_ChIP-Seq_NPCS_Mouse1.33963258
91EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.30190806
92ZNF217_24962896_ChIP-Seq_MCF-7_Human1.29609886
93POU5F1_16153702_ChIP-ChIP_HESCs_Human1.29456238
94TP53_22573176_ChIP-Seq_HFKS_Human1.29420433
95SOX2_21211035_ChIP-Seq_LN229_Gbm1.29107570
96VDR_22108803_ChIP-Seq_LS180_Human1.28821522
97EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.28492163
98BCAT_22108803_ChIP-Seq_LS180_Human1.27932233
99YY1_21170310_ChIP-Seq_MESCs_Mouse1.27816447
100MYC_19079543_ChIP-ChIP_MESCs_Mouse1.26327243
101EP300_21415370_ChIP-Seq_HL-1_Mouse1.26005826
102STAT3_23295773_ChIP-Seq_U87_Human1.25652283
103UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24481239
104ZNF274_21170338_ChIP-Seq_K562_Hela1.24424961
105HOXB4_20404135_ChIP-ChIP_EML_Mouse1.23472630
106FLI1_27457419_Chip-Seq_LIVER_Mouse1.22085612
107IGF1R_20145208_ChIP-Seq_DFB_Human1.21690365
108ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.21183109
109GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.20285479
110CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.19975005
111PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.19824913
112FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.18574897
113SMAD_19615063_ChIP-ChIP_OVARY_Human1.16411956
114RXR_22158963_ChIP-Seq_LIVER_Mouse1.16315460
115ER_23166858_ChIP-Seq_MCF-7_Human1.16259654
116NR3C1_21868756_ChIP-Seq_MCF10A_Human1.15340929
117TP53_18474530_ChIP-ChIP_U2OS_Human1.14031957
118SOX2_18555785_ChIP-Seq_MESCs_Mouse1.12784172
119CBX2_27304074_Chip-Seq_ESCs_Mouse1.12227930
120ARNT_22903824_ChIP-Seq_MCF-7_Human1.11925820
121YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11429626
122FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.11300118
123CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.11097314
124FUS_26573619_Chip-Seq_HEK293_Human1.10956063
125MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.10720494
126CBP_20019798_ChIP-Seq_JUKART_Human1.10640948
127IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.10640948
128MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.09641626
129SOX2_16153702_ChIP-ChIP_HESCs_Human1.09317010
130MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08442751
131ESR1_20079471_ChIP-ChIP_T-47D_Human1.08415371
132ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.08057610
133PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.07385037
134TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06567281
135BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.06000925
136BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.05694107
137FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.05214698
138RUNX2_22187159_ChIP-Seq_PCA_Human1.05189737
139RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.04954673
140HTT_18923047_ChIP-ChIP_STHdh_Human1.04670896
141JUN_21703547_ChIP-Seq_K562_Human1.04071694
142TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.03876749
143TCF4_23295773_ChIP-Seq_U87_Human1.03805019
144PADI4_21655091_ChIP-ChIP_MCF-7_Human1.03548003
145LXR_22158963_ChIP-Seq_LIVER_Mouse1.03290067
146TCF4_22108803_ChIP-Seq_LS180_Human1.03070672
147NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.02687384
148NANOG_18555785_Chip-Seq_ESCs_Mouse1.00644629
149AHR_22903824_ChIP-Seq_MCF-7_Human1.00530570
150KDM5A_27292631_Chip-Seq_BREAST_Human0.99972770
151NELFA_20434984_ChIP-Seq_ESCs_Mouse0.98461000
152E2F7_22180533_ChIP-Seq_HELA_Human0.97944528
153TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.97279275
154RXR_22108803_ChIP-Seq_LS180_Human0.97124916
155KDM2B_26808549_Chip-Seq_REH_Human0.96173292
156PRDM14_20953172_ChIP-Seq_ESCs_Human0.95582785
157WT1_19549856_ChIP-ChIP_CCG9911_Human0.95018441
158AR_20517297_ChIP-Seq_VCAP_Human0.94937877
159RBPJ_22232070_ChIP-Seq_NCS_Mouse0.94761790
160TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.94129534
161SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.92522872
162FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.92118340
163AR_19668381_ChIP-Seq_PC3_Human0.91977522
164TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91920678
165ELK1_22589737_ChIP-Seq_MCF10A_Human0.88981166
166GATA3_21878914_ChIP-Seq_MCF-7_Human0.86334749
167PCGF2_27294783_Chip-Seq_ESCs_Mouse0.85742299
168FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.85720448
169ERG_20887958_ChIP-Seq_HPC-7_Mouse0.84844763
170CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.84555445
171LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.83889504
172SOX2_19829295_ChIP-Seq_ESCs_Human0.83846011
173NANOG_19829295_ChIP-Seq_ESCs_Human0.83846011
174CTCF_18555785_ChIP-Seq_MESCs_Mouse0.83271770
175NCOR_22424771_ChIP-Seq_293T_Human0.82866543
176TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.82519243
177FOXA1_27270436_Chip-Seq_PROSTATE_Human0.80658997
178FOXA1_25329375_ChIP-Seq_VCAP_Human0.80658997
179NANOG_16153702_ChIP-ChIP_HESCs_Human0.80629359
180CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.80126392

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.98890345
2MP0004859_abnormal_synaptic_plasticity3.18057738
3MP0003880_abnormal_central_pattern3.03254472
4MP0008058_abnormal_DNA_repair2.89467869
5MP0004270_analgesia2.77100329
6MP0002837_dystrophic_cardiac_calcinosis2.76702409
7MP0009780_abnormal_chondrocyte_physiolo2.66901689
8MP0009379_abnormal_foot_pigmentation2.61237746
9MP0003635_abnormal_synaptic_transmissio2.59737120
10MP0008789_abnormal_olfactory_epithelium2.40441840
11MP0000013_abnormal_adipose_tissue2.38417930
12MP0009745_abnormal_behavioral_response2.37731646
13MP0002938_white_spotting2.27380988
14MP0002139_abnormal_hepatobiliary_system2.26752652
15MP0001968_abnormal_touch/_nociception2.26676860
16MP0009046_muscle_twitch2.26428915
17MP0000372_irregular_coat_pigmentation2.23499779
18MP0002102_abnormal_ear_morphology2.21802449
19MP0003806_abnormal_nucleotide_metabolis2.21110880
20MP0002876_abnormal_thyroid_physiology2.20793837
21MP0006072_abnormal_retinal_apoptosis2.20317352
22MP0008877_abnormal_DNA_methylation2.17425323
23MP0002064_seizures2.16359295
24MP0002063_abnormal_learning/memory/cond2.14575712
25MP0003186_abnormal_redox_activity2.10999636
26MP0002653_abnormal_ependyma_morphology2.08171451
27MP0005646_abnormal_pituitary_gland2.04249732
28MP0002735_abnormal_chemical_nociception1.97847321
29MP0002734_abnormal_mechanical_nocicepti1.97805794
30MP0002272_abnormal_nervous_system1.95853666
31MP0004043_abnormal_pH_regulation1.94257525
32MP0002736_abnormal_nociception_after1.93931126
33MP0003195_calcinosis1.88673715
34MP0002822_catalepsy1.87934063
35MP0002572_abnormal_emotion/affect_behav1.86179144
36MP0001984_abnormal_olfaction1.84199015
37MP0005085_abnormal_gallbladder_physiolo1.81736426
38MP0002909_abnormal_adrenal_gland1.80500759
39MP0005365_abnormal_bile_salt1.67438577
40MP0010386_abnormal_urinary_bladder1.65396056
41MP0003121_genomic_imprinting1.65070165
42MP0006035_abnormal_mitochondrial_morpho1.63041248
43MP0006276_abnormal_autonomic_nervous1.60953312
44MP0001501_abnormal_sleep_pattern1.60889245
45MP0000751_myopathy1.59100434
46MP0001486_abnormal_startle_reflex1.58221396
47MP0005499_abnormal_olfactory_system1.57623989
48MP0005394_taste/olfaction_phenotype1.57623989
49MP0008875_abnormal_xenobiotic_pharmacok1.56177869
50MP0004145_abnormal_muscle_electrophysio1.55278843
51MP0002067_abnormal_sensory_capabilities1.55192424
52MP0004130_abnormal_muscle_cell1.54999361
53MP0000631_abnormal_neuroendocrine_gland1.47949923
54MP0005253_abnormal_eye_physiology1.46468949
55MP0005645_abnormal_hypothalamus_physiol1.40644194
56MP0000749_muscle_degeneration1.40295601
57MP0005535_abnormal_body_temperature1.39454820
58MP0008569_lethality_at_weaning1.35636871
59MP0004036_abnormal_muscle_relaxation1.35633064
60MP0005360_urolithiasis1.33732810
61MP0002234_abnormal_pharynx_morphology1.32447816
62MP0003646_muscle_fatigue1.31969648
63MP0001293_anophthalmia1.30872468
64MP0002733_abnormal_thermal_nociception1.30626238
65MP0002638_abnormal_pupillary_reflex1.29553992
66MP0001970_abnormal_pain_threshold1.28524500
67MP0001986_abnormal_taste_sensitivity1.25842839
68MP0001440_abnormal_grooming_behavior1.25660942
69MP0004924_abnormal_behavior1.25348162
70MP0005386_behavior/neurological_phenoty1.25348162
71MP0002160_abnormal_reproductive_system1.24783904
72MP0010094_abnormal_chromosome_stability1.24703168
73MP0004133_heterotaxia1.24690212
74MP0003879_abnormal_hair_cell1.24292414
75MP0003633_abnormal_nervous_system1.23106308
76MP0003718_maternal_effect1.22714386
77MP0002163_abnormal_gland_morphology1.22556475
78MP0001188_hyperpigmentation1.21367474
79MP0004215_abnormal_myocardial_fiber1.20997405
80MP0003122_maternal_imprinting1.19669232
81MP0004142_abnormal_muscle_tone1.18561997
82MP0004147_increased_porphyrin_level1.18475839
83MP0009697_abnormal_copulation1.16683280
84MP0005084_abnormal_gallbladder_morpholo1.15520643
85MP0003011_delayed_dark_adaptation1.14642765
86MP0010329_abnormal_lipoprotein_level1.13117904
87MP0005332_abnormal_amino_acid1.12861695
88MP0002557_abnormal_social/conspecific_i1.12404344
89MP0000049_abnormal_middle_ear1.12164368
90MP0008932_abnormal_embryonic_tissue1.11022023
91MP0002078_abnormal_glucose_homeostasis1.09570639
92MP0003183_abnormal_peptide_metabolism1.08002202
93MP0001502_abnormal_circadian_rhythm1.06565600
94MP0003123_paternal_imprinting1.06489337
95MP0002184_abnormal_innervation1.03043408
96MP0000230_abnormal_systemic_arterial1.02952882
97MP0003329_amyloid_beta_deposits1.01900396
98MP0005620_abnormal_muscle_contractility1.01532261
99MP0004085_abnormal_heartbeat1.01256512
100MP0002277_abnormal_respiratory_mucosa1.00630522
101MP0006036_abnormal_mitochondrial_physio0.98602814
102MP0001905_abnormal_dopamine_level0.96829565
103MP0005389_reproductive_system_phenotype0.95154510
104MP0002066_abnormal_motor_capabilities/c0.94615857
105MP0005379_endocrine/exocrine_gland_phen0.94318309
106MP0005187_abnormal_penis_morphology0.94145792
107MP0001177_atelectasis0.93549446
108MP0002118_abnormal_lipid_homeostasis0.91877218
109MP0008775_abnormal_heart_ventricle0.91002435
110MP0005410_abnormal_fertilization0.89261981
111MP0005464_abnormal_platelet_physiology0.88309145
112MP0004484_altered_response_of0.88143298
113MP0004858_abnormal_nervous_system0.88127068
114MP0002877_abnormal_melanocyte_morpholog0.87636113
115MP0003787_abnormal_imprinting0.87320531
116MP0003315_abnormal_perineum_morphology0.86797125
117MP0004885_abnormal_endolymph0.86761439
118MP0004811_abnormal_neuron_physiology0.85342131
119MP0003137_abnormal_impulse_conducting0.84295677
120MP0001764_abnormal_homeostasis0.83101634
121MP0003631_nervous_system_phenotype0.82644788
122MP0002069_abnormal_eating/drinking_beha0.82314129
123MP0002090_abnormal_vision0.82192730
124MP0003119_abnormal_digestive_system0.81898343
125MP0002972_abnormal_cardiac_muscle0.81761120
126MP0001529_abnormal_vocalization0.81008500
127MP0003252_abnormal_bile_duct0.80204216
128MP0008872_abnormal_physiological_respon0.79373754
129MP0005448_abnormal_energy_balance0.77997251
130MP0001299_abnormal_eye_distance/0.77814790
131MP0005083_abnormal_biliary_tract0.77761771
132MP0005551_abnormal_eye_electrophysiolog0.77052197
133MP0000955_abnormal_spinal_cord0.76519998
134MP0003890_abnormal_embryonic-extraembry0.76293495
135MP0005584_abnormal_enzyme/coenzyme_acti0.76233356
136MP0002282_abnormal_trachea_morphology0.75284620
137MP0002229_neurodegeneration0.75099761
138MP0003937_abnormal_limbs/digits/tail_de0.73835408
139MP0001765_abnormal_ion_homeostasis0.73225393
140MP0001664_abnormal_digestion0.73144975
141MP0000003_abnormal_adipose_tissue0.72423091
142MP0002882_abnormal_neuron_morphology0.72200196
143MP0001666_abnormal_nutrient_absorption0.72158759
144MP0003953_abnormal_hormone_level0.71240519
145MP0002752_abnormal_somatic_nervous0.69719563
146MP0002095_abnormal_skin_pigmentation0.69094680
147MP0000358_abnormal_cell_content/0.68279484
148MP0003693_abnormal_embryo_hatching0.67780778
149MP0005195_abnormal_posterior_eye0.67247816
150MP0005391_vision/eye_phenotype0.66959177
151MP0001661_extended_life_span0.66863435
152MP0000516_abnormal_urinary_system0.65029165
153MP0005367_renal/urinary_system_phenotyp0.65029165
154MP0001485_abnormal_pinna_reflex0.64857058
155MP0002233_abnormal_nose_morphology0.64813408
156MP0003111_abnormal_nucleus_morphology0.64159807
157MP0000639_abnormal_adrenal_gland0.63356877
158MP0008007_abnormal_cellular_replicative0.63134042
159MP0008995_early_reproductive_senescence0.63090160

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.04314503
2Pheochromocytoma (HP:0002666)4.02148358
3Atonic seizures (HP:0010819)3.83142533
43-Methylglutaconic aciduria (HP:0003535)3.77064564
5Hyperventilation (HP:0002883)3.69372811
6Neuroendocrine neoplasm (HP:0100634)3.67196345
7Increased hepatocellular lipid droplets (HP:0006565)3.58573993
8Decreased activity of mitochondrial respiratory chain (HP:0008972)3.55685894
9Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.55685894
10Lipid accumulation in hepatocytes (HP:0006561)3.44265779
11Epileptic encephalopathy (HP:0200134)3.38591020
12Febrile seizures (HP:0002373)3.33782042
13Increased intramyocellular lipid droplets (HP:0012240)3.22953876
14Oligomenorrhea (HP:0000876)3.22121209
15Renal Fanconi syndrome (HP:0001994)3.20628480
16Colon cancer (HP:0003003)3.18923047
17Abnormality of cells of the erythroid lineage (HP:0012130)3.07020424
18Abnormal mitochondria in muscle tissue (HP:0008316)3.04192491
19Absence seizures (HP:0002121)2.99881286
20Visual hallucinations (HP:0002367)2.99009223
21Hypothermia (HP:0002045)2.97113693
22Myokymia (HP:0002411)2.95206491
23Abnormal respiratory motile cilium morphology (HP:0005938)2.92481708
24Abnormal respiratory epithelium morphology (HP:0012253)2.92481708
25Focal seizures (HP:0007359)2.90953191
26Acute necrotizing encephalopathy (HP:0006965)2.89423865
27Ketoacidosis (HP:0001993)2.88495756
28Abnormal number of erythroid precursors (HP:0012131)2.85975072
29Increased serum lactate (HP:0002151)2.85477288
30Exercise-induced myalgia (HP:0003738)2.79428232
31Increased muscle lipid content (HP:0009058)2.76655984
32Progressive macrocephaly (HP:0004481)2.74617787
33Acute encephalopathy (HP:0006846)2.73648470
34Respiratory failure (HP:0002878)2.70263671
35Exercise intolerance (HP:0003546)2.69482858
36Hypoglycemic coma (HP:0001325)2.68041720
37Generalized tonic-clonic seizures (HP:0002069)2.67183233
38Hypoglycemic seizures (HP:0002173)2.64113589
39Absent/shortened dynein arms (HP:0200106)2.62009039
40Dynein arm defect of respiratory motile cilia (HP:0012255)2.62009039
41Dialeptic seizures (HP:0011146)2.54219976
42Optic disc pallor (HP:0000543)2.50681827
43Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.49935748
44Molar tooth sign on MRI (HP:0002419)2.47800050
45Abnormality of midbrain morphology (HP:0002418)2.47800050
46Pancreatic cysts (HP:0001737)2.47345023
47Abnormal ciliary motility (HP:0012262)2.46526352
48Congenital stationary night blindness (HP:0007642)2.45327348
49Exercise-induced muscle cramps (HP:0003710)2.42434083
50Anxiety (HP:0000739)2.41708252
51Hepatic necrosis (HP:0002605)2.40306875
52Abnormality of aromatic amino acid family metabolism (HP:0004338)2.40211150
53Ketosis (HP:0001946)2.38302590
54Myoglobinuria (HP:0002913)2.35186290
55Macrocytic anemia (HP:0001972)2.34954163
56Pancreatic fibrosis (HP:0100732)2.34905708
57Reticulocytopenia (HP:0001896)2.33782772
58Exertional dyspnea (HP:0002875)2.32812556
59Nephronophthisis (HP:0000090)2.31846763
60Hyperinsulinemic hypoglycemia (HP:0000825)2.29943978
61Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.29478103
62Degeneration of the lateral corticospinal tracts (HP:0002314)2.29478103
63Abnormal respiratory motile cilium physiology (HP:0012261)2.29369895
64Hepatocellular necrosis (HP:0001404)2.28716903
65Muscle hypertrophy of the lower extremities (HP:0008968)2.27752280
66Decreased electroretinogram (ERG) amplitude (HP:0000654)2.26864554
67Calf muscle hypertrophy (HP:0008981)2.26760985
68Leukodystrophy (HP:0002415)2.26691838
69Mitochondrial inheritance (HP:0001427)2.20884351
70Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.20781810
71Cerebral edema (HP:0002181)2.20435084
72Gout (HP:0001997)2.19381523
73Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.17282162
74Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.16853077
75Symptomatic seizures (HP:0011145)2.16838824
76Lethargy (HP:0001254)2.15972210
77Absent rod-and cone-mediated responses on ERG (HP:0007688)2.15815885
78Abolished electroretinogram (ERG) (HP:0000550)2.15228574
79Decreased central vision (HP:0007663)2.14264696
80Action tremor (HP:0002345)2.13671734
81Supernumerary spleens (HP:0009799)2.12435901
82Progressive cerebellar ataxia (HP:0002073)2.11486794
83Epileptiform EEG discharges (HP:0011182)2.10332918
84Myotonia (HP:0002486)2.10306706
85Abnormal protein glycosylation (HP:0012346)2.08522185
86Abnormal glycosylation (HP:0012345)2.08522185
87Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.08522185
88Abnormal protein N-linked glycosylation (HP:0012347)2.08522185
89Hyperglycinemia (HP:0002154)2.04973264
90Scanning speech (HP:0002168)2.02297869
91Increased CSF lactate (HP:0002490)2.01767418
92Poor suck (HP:0002033)1.99921952
93Abnormal eating behavior (HP:0100738)1.98722161
94Blue irides (HP:0000635)1.98493739
95Broad-based gait (HP:0002136)1.96811860
96Abnormality of renal resorption (HP:0011038)1.96228008
97EEG with generalized epileptiform discharges (HP:0011198)1.96099601
98Adrenal hypoplasia (HP:0000835)1.94709575
99Neoplasm of the peripheral nervous system (HP:0100007)1.94387437
100Asplenia (HP:0001746)1.93373181
101Type I transferrin isoform profile (HP:0003642)1.93363533
102Abnormal rod and cone electroretinograms (HP:0008323)1.93284369
103True hermaphroditism (HP:0010459)1.92530894
104Dysdiadochokinesis (HP:0002075)1.92378066
105Torticollis (HP:0000473)1.90987462
106Neoplasm of the adrenal gland (HP:0100631)1.90749510
107Optic nerve hypoplasia (HP:0000609)1.90599954
108Median cleft lip (HP:0000161)1.89959849
109Hyperglycemia (HP:0003074)1.89526662
110Failure to thrive in infancy (HP:0001531)1.89355714
111Opisthotonus (HP:0002179)1.88413100
112Insulin-resistant diabetes mellitus (HP:0000831)1.88308565
113Abnormality of the renal medulla (HP:0100957)1.86230523
114Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.85881366
115Conjunctival hamartoma (HP:0100780)1.85205652
116Abnormal hair whorl (HP:0010721)1.84908866
117Poor head control (HP:0002421)1.82683663
118Abnormality of the calf musculature (HP:0001430)1.82215990
119Progressive microcephaly (HP:0000253)1.81996303
120Bradycardia (HP:0001662)1.81503864
121Truncal ataxia (HP:0002078)1.81491550
122Abnormality of alanine metabolism (HP:0010916)1.80980305
123Hyperalaninemia (HP:0003348)1.80980305
124Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.80980305
125Hypsarrhythmia (HP:0002521)1.80855688
126Depression (HP:0000716)1.80773666
127Lactic acidosis (HP:0003128)1.80431959
128Methylmalonic acidemia (HP:0002912)1.80420550
129Aplasia/Hypoplasia of the spleen (HP:0010451)1.80235719
130Generalized aminoaciduria (HP:0002909)1.80231258
131Palpitations (HP:0001962)1.79772198
132Gait imbalance (HP:0002141)1.78778221
133Abnormal gallbladder morphology (HP:0012437)1.78496592
134Abnormality of pain sensation (HP:0010832)1.78444856
135Impaired pain sensation (HP:0007328)1.78444856
136Methylmalonic aciduria (HP:0012120)1.77402217
137Abnormal number of incisors (HP:0011064)1.77324215
138Glycosuria (HP:0003076)1.77215634
139Abnormality of urine glucose concentration (HP:0011016)1.77215634
140Focal dystonia (HP:0004373)1.76932948
141Neoplasm of the adrenal cortex (HP:0100641)1.75264684
142CNS demyelination (HP:0007305)1.75207125
143Septo-optic dysplasia (HP:0100842)1.74970769
144Craniofacial dystonia (HP:0012179)1.74723116
145Aplastic anemia (HP:0001915)1.74256885
146Abnormality of macular pigmentation (HP:0008002)1.74172874
147Growth hormone deficiency (HP:0000824)1.73878721
148Hypoplastic pelvis (HP:0008839)1.73789445
149Congenital primary aphakia (HP:0007707)1.71183991
150Abnormality of the intrinsic pathway (HP:0010989)1.70915707
151Cerebral hemorrhage (HP:0001342)1.70317265
152Emotional lability (HP:0000712)1.70189532
153Impaired vibration sensation in the lower limbs (HP:0002166)1.69455300
154Gaze-evoked nystagmus (HP:0000640)1.69268357
155Type II lissencephaly (HP:0007260)1.68518365
156Abnormality of fatty-acid metabolism (HP:0004359)1.67987299
157Progressive inability to walk (HP:0002505)1.67597543
158Glioma (HP:0009733)1.66462797
159Cerebral hypomyelination (HP:0006808)1.66221926
160Retinal dysplasia (HP:0007973)1.65581078
161Cholecystitis (HP:0001082)1.65090237
162Abnormal gallbladder physiology (HP:0012438)1.65090237
163Medial flaring of the eyebrow (HP:0010747)1.63543939
164Prolonged QT interval (HP:0001657)1.63325486
165Abnormality of the corticospinal tract (HP:0002492)1.63324956
166Poor eye contact (HP:0000817)1.62901480
167Dicarboxylic aciduria (HP:0003215)1.62899348
168Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.61787029
169X-linked dominant inheritance (HP:0001423)1.60083738
170Conjugated hyperbilirubinemia (HP:0002908)1.59923379
171Resting tremor (HP:0002322)1.59049795
172Agitation (HP:0000713)1.58939509
173Nephrogenic diabetes insipidus (HP:0009806)1.58538568
174Central scotoma (HP:0000603)1.58321641
175Sensorimotor neuropathy (HP:0007141)1.57902791
176Cholelithiasis (HP:0001081)1.57594821
177Hypoventilation (HP:0002791)1.56798687
178Impaired social interactions (HP:0000735)1.56552017

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.97547525
2ZAK3.92705504
3NUAK13.28030804
4MAP4K23.21178396
5NTRK33.16723929
6STK162.82628422
7CDC72.52459126
8MAP2K72.52096497
9MAP3K122.51049630
10VRK22.50709253
11MAP3K42.34592810
12INSRR2.33653225
13EPHA42.03984986
14MAP2K41.96535716
15MINK11.93766219
16DAPK21.91279350
17PRPF4B1.90864803
18DYRK21.86940901
19CAMKK21.85798376
20SIK31.85204615
21AKT31.80408922
22SGK21.79111960
23FRK1.77807296
24PLK21.76467875
25CSNK1G31.71971469
26CSNK1G21.70220451
27SGK4941.65120575
28SGK2231.65120575
29PLK41.64671697
30BCKDK1.60539358
31SRPK11.54036239
32CSNK1G11.47443793
33TAOK31.46605380
34EIF2AK11.44066177
35PINK11.42193827
36PDK31.40250018
37PDK41.40250018
38NTRK11.37961678
39NME21.37722826
40MYLK1.35882691
41OXSR11.34165580
42PRKD31.32825558
43BCR1.28866885
44GRK11.28618328
45TRIM281.26470064
46PLK31.26075569
47PHKG11.24362970
48PHKG21.24362970
49CSNK1A1L1.23098634
50LATS11.22204287
51ERBB31.21106986
52SGK31.21005708
53VRK11.20870062
54OBSCN1.19760794
55BMPR21.19120649
56KDR1.17033366
57DAPK11.15965610
58MAP3K21.14566665
59TLK11.12931408
60PIM21.10959870
61CAMKK11.10772685
62CDK191.10196719
63MST41.08682237
64GRK51.08491558
65NME11.08366800
66PASK1.07838737
67PLK11.07074811
68MUSK1.06866953
69BUB11.05647344
70PIK3CA1.04659830
71MAPK131.04074683
72ARAF1.03569122
73PRKCE1.01610449
74PRKCG1.00876727
75PBK1.00517667
76FER1.00337827
77MKNK20.99210682
78PDK20.97426067
79CDK50.96474038
80KSR10.94494861
81CAMK2A0.94176519
82WNK40.94077717
83PRKCH0.92740478
84MKNK10.92521825
85TNIK0.92004816
86CHEK20.91767376
87TEC0.90030792
88STK38L0.89051846
89WNK30.87293837
90MAP2K10.86943973
91ABL20.84707793
92NEK10.84253977
93LMTK20.82637151
94CDK80.81527693
95TAF10.74841754
96CAMK2B0.73562377
97RPS6KA50.73265401
98STK240.73143410
99TNK20.72939309
100ATR0.72282346
101WEE10.72161065
102KSR20.70944393
103CAMK2G0.70453762
104PAK30.70373646
105CAMK2D0.69052905
106AURKA0.68387535
107PAK60.68214302
108TIE10.68177651
109SCYL20.66309572
110BRSK20.65176495
111RIPK40.64592868
112EPHB20.62581500
113MAP3K90.62102563
114NTRK20.61430018
115SGK10.61072645
116MARK10.60541636
117ADRBK20.60056588
118CSNK2A20.58966301
119CSNK2A10.58345811
120BMPR1B0.57776496
121RPS6KA40.56885529
122PTK2B0.56290369
123AURKB0.55322009
124DAPK30.55189562
125TXK0.54340942
126TTK0.54221813
127GRK70.53418687
128STK390.52654182
129RPS6KA20.52332822
130WNK10.51881643
131MAPK120.51320316
132NEK60.50682328
133PIK3CG0.50618464
134FGFR20.50575172
135PRKACA0.50302423
136PKN10.49595018
137LIMK10.48211773
138MAP3K110.48055811
139NEK90.47148154
140RET0.46276822
141PRKCQ0.45519732
142CAMK10.45412576
143DYRK30.44423294
144STK380.44417165
145ERBB40.44342426
146MAP3K10.43855721
147CDK30.43693246
148RPS6KB10.43301198
149CSNK1A10.41745797
150ADRBK10.41318863
151PRKACG0.41008526
152CCNB10.40888916
153MAPKAPK50.40590368
154BRAF0.39767629
155PDPK10.39394491
156ROCK10.39336308
157CSNK1E0.39041931
158PRKG20.37356657
159BRSK10.36317738
160CDK140.36124681
161ATM0.34972530
162EPHA30.34511418

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.12350888
2Proteasome_Homo sapiens_hsa030503.33759933
3RNA polymerase_Homo sapiens_hsa030202.68301852
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.64675257
5Synaptic vesicle cycle_Homo sapiens_hsa047212.57166236
6Mismatch repair_Homo sapiens_hsa034302.50848482
7Base excision repair_Homo sapiens_hsa034102.50606870
8Homologous recombination_Homo sapiens_hsa034402.25574359
9Nicotine addiction_Homo sapiens_hsa050332.20825189
10DNA replication_Homo sapiens_hsa030302.16935017
11Collecting duct acid secretion_Homo sapiens_hsa049661.93397856
12GABAergic synapse_Homo sapiens_hsa047271.89946202
13Sulfur relay system_Homo sapiens_hsa041221.87001861
14Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.86977241
15Propanoate metabolism_Homo sapiens_hsa006401.85130082
16Pyrimidine metabolism_Homo sapiens_hsa002401.84498513
17Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.75932810
18Sulfur metabolism_Homo sapiens_hsa009201.75052541
19Insulin secretion_Homo sapiens_hsa049111.74335860
20Olfactory transduction_Homo sapiens_hsa047401.71502223
21Butanoate metabolism_Homo sapiens_hsa006501.71000853
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.70492093
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.70110010
24Circadian entrainment_Homo sapiens_hsa047131.68723967
25Spliceosome_Homo sapiens_hsa030401.66888973
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.66542053
27Fanconi anemia pathway_Homo sapiens_hsa034601.65559209
28Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.60917573
29Morphine addiction_Homo sapiens_hsa050321.56873023
30Nucleotide excision repair_Homo sapiens_hsa034201.54071423
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.52571166
32Vibrio cholerae infection_Homo sapiens_hsa051101.52505199
33Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.50763925
34Amphetamine addiction_Homo sapiens_hsa050311.50755591
35Oxidative phosphorylation_Homo sapiens_hsa001901.47208686
36Long-term potentiation_Homo sapiens_hsa047201.46719316
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.45173269
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.42448620
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.38892805
40Nitrogen metabolism_Homo sapiens_hsa009101.38801661
41Pyruvate metabolism_Homo sapiens_hsa006201.37754675
42RNA degradation_Homo sapiens_hsa030181.37363734
43Renin secretion_Homo sapiens_hsa049241.35789940
44Glutamatergic synapse_Homo sapiens_hsa047241.35423630
45Dopaminergic synapse_Homo sapiens_hsa047281.34960349
46Primary bile acid biosynthesis_Homo sapiens_hsa001201.33368960
47Taste transduction_Homo sapiens_hsa047421.33359561
48Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.31738902
49Phototransduction_Homo sapiens_hsa047441.31127180
50Maturity onset diabetes of the young_Homo sapiens_hsa049501.30328324
51Fatty acid metabolism_Homo sapiens_hsa012121.29778773
52Fatty acid degradation_Homo sapiens_hsa000711.28830694
53Purine metabolism_Homo sapiens_hsa002301.27408903
54Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.24768590
55Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.23287215
56Salivary secretion_Homo sapiens_hsa049701.21610301
57Fatty acid elongation_Homo sapiens_hsa000621.18902986
58Serotonergic synapse_Homo sapiens_hsa047261.10498643
59Basal transcription factors_Homo sapiens_hsa030221.08041990
60Alzheimers disease_Homo sapiens_hsa050101.07286496
61Peroxisome_Homo sapiens_hsa041461.06375850
62Cholinergic synapse_Homo sapiens_hsa047251.05308307
63Parkinsons disease_Homo sapiens_hsa050121.05076946
64Aldosterone synthesis and secretion_Homo sapiens_hsa049251.04074876
65Gastric acid secretion_Homo sapiens_hsa049711.03439484
66Arginine biosynthesis_Homo sapiens_hsa002201.03159814
67Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.01308296
68RNA transport_Homo sapiens_hsa030130.99056513
69Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.98333946
70Calcium signaling pathway_Homo sapiens_hsa040200.98168023
71Regulation of autophagy_Homo sapiens_hsa041400.97736194
72Cocaine addiction_Homo sapiens_hsa050300.97456751
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.95476458
74Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.94365732
75Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.94311358
76Cardiac muscle contraction_Homo sapiens_hsa042600.93713195
77Long-term depression_Homo sapiens_hsa047300.91497522
78Glutathione metabolism_Homo sapiens_hsa004800.91411009
79SNARE interactions in vesicular transport_Homo sapiens_hsa041300.90842725
80Tryptophan metabolism_Homo sapiens_hsa003800.88497336
81Protein export_Homo sapiens_hsa030600.88215324
82Metabolic pathways_Homo sapiens_hsa011000.87859856
83Oxytocin signaling pathway_Homo sapiens_hsa049210.85479832
84Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.83538125
85Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.82363983
86Non-homologous end-joining_Homo sapiens_hsa034500.81653346
87Glucagon signaling pathway_Homo sapiens_hsa049220.80492305
88Chemical carcinogenesis_Homo sapiens_hsa052040.79296144
89Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.79284712
90Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.78551839
91Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.78260081
92PPAR signaling pathway_Homo sapiens_hsa033200.78136565
93Starch and sucrose metabolism_Homo sapiens_hsa005000.77247827
94Carbon metabolism_Homo sapiens_hsa012000.76881329
95Bile secretion_Homo sapiens_hsa049760.76581907
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.75092952
97Type II diabetes mellitus_Homo sapiens_hsa049300.74801124
98Pancreatic secretion_Homo sapiens_hsa049720.74679592
99Folate biosynthesis_Homo sapiens_hsa007900.74321507
100beta-Alanine metabolism_Homo sapiens_hsa004100.74156350
101Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.73356749
102Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.72289662
103One carbon pool by folate_Homo sapiens_hsa006700.72189806
104Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71278502
105Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.71223287
106cAMP signaling pathway_Homo sapiens_hsa040240.70485836
107cGMP-PKG signaling pathway_Homo sapiens_hsa040220.70095115
108Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.69468433
109Cysteine and methionine metabolism_Homo sapiens_hsa002700.68712927
110Vascular smooth muscle contraction_Homo sapiens_hsa042700.67068819
111Phenylalanine metabolism_Homo sapiens_hsa003600.66327735
112Thyroid hormone synthesis_Homo sapiens_hsa049180.65655895
113Arachidonic acid metabolism_Homo sapiens_hsa005900.65350993
114Drug metabolism - other enzymes_Homo sapiens_hsa009830.64902241
115Circadian rhythm_Homo sapiens_hsa047100.60150299
116Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.59296649
117Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.59228284
118Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.58768617
119Dilated cardiomyopathy_Homo sapiens_hsa054140.57656906
120Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.57478456
121Fatty acid biosynthesis_Homo sapiens_hsa000610.56969863
122Retinol metabolism_Homo sapiens_hsa008300.55692449
123Asthma_Homo sapiens_hsa053100.55253406
124Gap junction_Homo sapiens_hsa045400.52239031
125Tyrosine metabolism_Homo sapiens_hsa003500.51703972
126Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.50784998
127Steroid biosynthesis_Homo sapiens_hsa001000.49423345
128Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49251816
129GnRH signaling pathway_Homo sapiens_hsa049120.47540520
130Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.47473233
131Insulin signaling pathway_Homo sapiens_hsa049100.45149313
132Systemic lupus erythematosus_Homo sapiens_hsa053220.44385918
133Hedgehog signaling pathway_Homo sapiens_hsa043400.43988341
134Huntingtons disease_Homo sapiens_hsa050160.43475508
135Rheumatoid arthritis_Homo sapiens_hsa053230.43093748
136Phosphatidylinositol signaling system_Homo sapiens_hsa040700.42518504
137Cell cycle_Homo sapiens_hsa041100.40907205
138Glycerolipid metabolism_Homo sapiens_hsa005610.39922366
139Steroid hormone biosynthesis_Homo sapiens_hsa001400.38382665
140Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.38370281
141Pentose and glucuronate interconversions_Homo sapiens_hsa000400.38173421
142Type I diabetes mellitus_Homo sapiens_hsa049400.37377719
143Arginine and proline metabolism_Homo sapiens_hsa003300.37351207
144Phagosome_Homo sapiens_hsa041450.37263505
145Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37136585
146Melanogenesis_Homo sapiens_hsa049160.35467484
147Carbohydrate digestion and absorption_Homo sapiens_hsa049730.35205231
148Linoleic acid metabolism_Homo sapiens_hsa005910.34026572
149Oocyte meiosis_Homo sapiens_hsa041140.33820766
150Selenocompound metabolism_Homo sapiens_hsa004500.30759184
151alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.28846905
152Intestinal immune network for IgA production_Homo sapiens_hsa046720.28827480
153Ether lipid metabolism_Homo sapiens_hsa005650.28521715
154Alcoholism_Homo sapiens_hsa050340.28260266
155Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.23518662
156N-Glycan biosynthesis_Homo sapiens_hsa005100.19426614

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