SMIM10L2A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.78639218
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.77153117
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.49239790
4synaptic vesicle exocytosis (GO:0016079)5.47781757
5regulation of synaptic vesicle exocytosis (GO:2000300)5.20944433
6locomotory exploration behavior (GO:0035641)5.13818727
7cellular potassium ion homeostasis (GO:0030007)5.02666587
8vocalization behavior (GO:0071625)4.93336105
9glutamate secretion (GO:0014047)4.92326451
10protein localization to synapse (GO:0035418)4.91907225
11neuron cell-cell adhesion (GO:0007158)4.80981282
12positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.80947550
13regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.77381677
14sodium ion export (GO:0071436)4.76857404
15regulation of synaptic vesicle transport (GO:1902803)4.52980833
16neurotransmitter secretion (GO:0007269)4.45549503
17regulation of glutamate receptor signaling pathway (GO:1900449)4.40922720
18regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.33484333
19positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.32358218
20exploration behavior (GO:0035640)4.31962370
21L-amino acid import (GO:0043092)4.27580639
22synaptic vesicle docking involved in exocytosis (GO:0016081)4.24715773
23neuronal action potential propagation (GO:0019227)4.24470721
24mating behavior (GO:0007617)4.16219836
25cerebellar granule cell differentiation (GO:0021707)4.10781522
26layer formation in cerebral cortex (GO:0021819)4.01398629
27ionotropic glutamate receptor signaling pathway (GO:0035235)3.98364007
28proline transport (GO:0015824)3.94452747
29regulation of long-term neuronal synaptic plasticity (GO:0048169)3.94450199
30negative regulation of microtubule polymerization (GO:0031115)3.92836289
31amino acid import (GO:0043090)3.91802201
32regulation of neuronal synaptic plasticity (GO:0048168)3.88239113
33neuron-neuron synaptic transmission (GO:0007270)3.83742900
34regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.82136307
35synaptic transmission, glutamatergic (GO:0035249)3.78366944
36neuronal ion channel clustering (GO:0045161)3.77286197
37positive regulation of dendritic spine development (GO:0060999)3.72451228
38neurotransmitter transport (GO:0006836)3.70528293
39postsynaptic membrane organization (GO:0001941)3.68217950
40potassium ion import (GO:0010107)3.67409860
41dendritic spine morphogenesis (GO:0060997)3.66885224
42synaptic vesicle endocytosis (GO:0048488)3.66046557
43potassium ion homeostasis (GO:0055075)3.65275254
44cell communication by electrical coupling (GO:0010644)3.64037296
45response to insecticide (GO:0017085)3.61315985
46glutamate receptor signaling pathway (GO:0007215)3.54647868
47positive regulation of synapse maturation (GO:0090129)3.53905677
48regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.49669824
49regulation of vesicle fusion (GO:0031338)3.49290165
50neuron recognition (GO:0008038)3.48952259
51positive regulation of membrane potential (GO:0045838)3.48185519
52regulation of voltage-gated calcium channel activity (GO:1901385)3.47284764
53positive regulation of synaptic transmission, GABAergic (GO:0032230)3.45713524
54axon ensheathment in central nervous system (GO:0032291)3.45112993
55central nervous system myelination (GO:0022010)3.45112993
56regulation of synapse structural plasticity (GO:0051823)3.42712535
57long-term memory (GO:0007616)3.38405926
58negative regulation of synaptic transmission, GABAergic (GO:0032229)3.36973004
59gamma-aminobutyric acid transport (GO:0015812)3.36952459
60regulation of neurotransmitter secretion (GO:0046928)3.35451191
61startle response (GO:0001964)3.33520548
62regulation of neurotransmitter levels (GO:0001505)3.33444341
63regulation of excitatory postsynaptic membrane potential (GO:0060079)3.32985192
64cellular sodium ion homeostasis (GO:0006883)3.30087067
65regulation of postsynaptic membrane potential (GO:0060078)3.28370778
66presynaptic membrane assembly (GO:0097105)3.25287008
67innervation (GO:0060384)3.23993618
68cell migration in hindbrain (GO:0021535)3.22402977
69transmission of nerve impulse (GO:0019226)3.21908849
70activation of protein kinase A activity (GO:0034199)3.21587185
71membrane depolarization during action potential (GO:0086010)3.18724373
72regulation of ARF protein signal transduction (GO:0032012)3.17821882
73regulation of synaptic plasticity (GO:0048167)3.17311009
74neurotransmitter-gated ion channel clustering (GO:0072578)3.16293241
75cytoskeletal anchoring at plasma membrane (GO:0007016)3.14954090
76cerebellar Purkinje cell differentiation (GO:0021702)3.11015827
77neuromuscular process controlling posture (GO:0050884)3.09654281
78positive regulation of neurotransmitter secretion (GO:0001956)3.09426247
79gamma-aminobutyric acid signaling pathway (GO:0007214)3.08863313
80synaptic vesicle transport (GO:0048489)3.07592318
81establishment of synaptic vesicle localization (GO:0097480)3.07592318
82long-term synaptic potentiation (GO:0060291)3.07475168
83vesicle transport along microtubule (GO:0047496)3.07421306
84regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.05964206
85regulation of dendritic spine development (GO:0060998)3.05948698
86regulation of synaptic transmission (GO:0050804)3.04559111
87membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.03721368
88synapse assembly (GO:0007416)3.01708829
89regulation of neurotransmitter transport (GO:0051588)3.00992444
90positive regulation of neurotransmitter transport (GO:0051590)3.00959858
91detection of calcium ion (GO:0005513)3.00201024
92auditory behavior (GO:0031223)2.99703919
93cell communication involved in cardiac conduction (GO:0086065)2.99409615
94regulation of calcium ion-dependent exocytosis (GO:0017158)2.99205411
95regulation of glutamate secretion (GO:0014048)2.98525353
96fear response (GO:0042596)2.95615184
97behavioral defense response (GO:0002209)2.95146260
98behavioral fear response (GO:0001662)2.95146260
99presynaptic membrane organization (GO:0097090)2.94740947
100intraspecies interaction between organisms (GO:0051703)2.94372091
101social behavior (GO:0035176)2.94372091
102positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.94279110
103axonal fasciculation (GO:0007413)2.93989524
104acidic amino acid transport (GO:0015800)2.93703766
105regulation of dendritic spine morphogenesis (GO:0061001)2.92366929
106synaptic transmission (GO:0007268)2.92123742
107cerebellar Purkinje cell layer development (GO:0021680)2.92008607
108organelle transport along microtubule (GO:0072384)2.91668630
109establishment of vesicle localization (GO:0051650)2.89848060
110regulation of synaptic transmission, GABAergic (GO:0032228)2.89143652
111learning (GO:0007612)2.88282345
112glucocorticoid metabolic process (GO:0008211)2.88013576
113axon cargo transport (GO:0008088)2.87538678
114regulation of synaptic transmission, glutamatergic (GO:0051966)2.86690554
115neuromuscular process controlling balance (GO:0050885)2.86008435
116glycine transport (GO:0015816)2.85986590
117neuromuscular synaptic transmission (GO:0007274)2.85472262
118regulation of synapse maturation (GO:0090128)2.85237266
119neuromuscular process (GO:0050905)2.84322392
120negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.82713135
121response to auditory stimulus (GO:0010996)2.79923358
122G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.77806477
123synapse organization (GO:0050808)2.77585671
124positive regulation of dendritic spine morphogenesis (GO:0061003)2.77541962
125negative regulation of dendrite morphogenesis (GO:0050774)2.77130268
126membrane depolarization (GO:0051899)2.77027999
127calcium ion-dependent exocytosis (GO:0017156)2.76766483
128cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.75525065
129dendritic spine organization (GO:0097061)2.74991063

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.51302561
2GBX2_23144817_ChIP-Seq_PC3_Human3.76132037
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.17797303
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.16350072
5REST_21632747_ChIP-Seq_MESCs_Mouse3.09421284
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.97996871
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.79115769
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.78668612
9NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.66089028
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.64584842
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.64584842
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.59263277
13REST_18959480_ChIP-ChIP_MESCs_Mouse2.51922847
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.47163596
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.45208938
16RARB_27405468_Chip-Seq_BRAIN_Mouse2.43086686
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.41771065
18MTF2_20144788_ChIP-Seq_MESCs_Mouse2.40869688
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.31283873
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.27898835
21CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.23778245
22EED_16625203_ChIP-ChIP_MESCs_Mouse2.18021093
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.10506950
24THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.08391047
25CTBP2_25329375_ChIP-Seq_LNCAP_Human2.08272447
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.07251491
27BMI1_23680149_ChIP-Seq_NPCS_Mouse1.90515861
28DROSHA_22980978_ChIP-Seq_HELA_Human1.86391899
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.85300414
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.80119301
31TAF15_26573619_Chip-Seq_HEK293_Human1.73690088
32IKZF1_21737484_ChIP-ChIP_HCT116_Human1.72092948
33KDM2B_26808549_Chip-Seq_K562_Human1.70427262
34ERG_21242973_ChIP-ChIP_JURKAT_Human1.66023474
35EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.65050676
36ZNF274_21170338_ChIP-Seq_K562_Hela1.63624323
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.62439894
38RNF2_27304074_Chip-Seq_NSC_Mouse1.59462809
39SMAD4_21799915_ChIP-Seq_A2780_Human1.59383298
40RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.48282052
41ZFP57_27257070_Chip-Seq_ESCs_Mouse1.47792157
42MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.47122030
43ZFP281_27345836_Chip-Seq_ESCs_Mouse1.42613857
44SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.41727614
45P300_19829295_ChIP-Seq_ESCs_Human1.41397911
46WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.39972111
47VDR_22108803_ChIP-Seq_LS180_Human1.39180742
48SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.39054907
49PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.37363421
50PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.35268908
51CBX2_27304074_Chip-Seq_ESCs_Mouse1.34748392
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32687630
53TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32529923
54ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.32368815
55IGF1R_20145208_ChIP-Seq_DFB_Human1.32312831
56RING1B_27294783_Chip-Seq_ESCs_Mouse1.32217130
57GATA1_26923725_Chip-Seq_HPCs_Mouse1.31275933
58NR3C1_23031785_ChIP-Seq_PC12_Mouse1.30894861
59AR_21572438_ChIP-Seq_LNCaP_Human1.28232731
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.27584440
61SOX2_21211035_ChIP-Seq_LN229_Gbm1.25428720
62RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.24521531
63ZFP281_18757296_ChIP-ChIP_E14_Mouse1.21414108
64ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.21264019
65FUS_26573619_Chip-Seq_HEK293_Human1.18729558
66RING1B_27294783_Chip-Seq_NPCs_Mouse1.17160949
67OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16936110
68STAT3_23295773_ChIP-Seq_U87_Human1.15128986
69RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.13309114
70RBPJ_22232070_ChIP-Seq_NCS_Mouse1.12795045
71AR_19668381_ChIP-Seq_PC3_Human1.12428051
72GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08321200
73P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07768740
74TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.07009489
75AR_25329375_ChIP-Seq_VCAP_Human1.06656321
76SMAD3_21741376_ChIP-Seq_ESCs_Human1.06462977
77CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.06102359
78YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04246405
79SRY_22984422_ChIP-ChIP_TESTIS_Rat1.04124832
80SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03648051
81TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02480362
82POU3F2_20337985_ChIP-ChIP_501MEL_Human1.02104320
83TCF4_23295773_ChIP-Seq_U87_Human1.01905196
84JUN_21703547_ChIP-Seq_K562_Human1.00128425
85SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00028993
86RUNX2_22187159_ChIP-Seq_PCA_Human0.97902998
87DNAJC2_21179169_ChIP-ChIP_NT2_Human0.97558653
88MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97111241
89LXR_22292898_ChIP-Seq_THP-1_Human0.96888026
90UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96601624
91SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.96219324
92PIAS1_25552417_ChIP-Seq_VCAP_Human0.94188302
93TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.93797483
94CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92680622
95CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.92119380
96ARNT_22903824_ChIP-Seq_MCF-7_Human0.91430698
97TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90354823
98GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.89176377
99TET1_21490601_ChIP-Seq_MESCs_Mouse0.88495451
100ESR2_21235772_ChIP-Seq_MCF-7_Human0.87759413
101TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.87733002
102SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.87482114
103WT1_25993318_ChIP-Seq_PODOCYTE_Human0.87451841
104OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.87193310
105SMAD4_21741376_ChIP-Seq_HESCs_Human0.86547686
106ER_23166858_ChIP-Seq_MCF-7_Human0.85071324
107CTCF_27219007_Chip-Seq_Bcells_Human0.84738051
108EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.83669427
109EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.83483371
110PRDM14_20953172_ChIP-Seq_ESCs_Human0.83458221
111DPY_21335234_ChIP-Seq_ESCs_Mouse0.83124902
112GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83094211
113POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.82350940
114TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82350940
115KDM2B_26808549_Chip-Seq_SUP-B15_Human0.81251294
116AHR_22903824_ChIP-Seq_MCF-7_Human0.81032256
117TP53_20018659_ChIP-ChIP_R1E_Mouse0.80777035
118CREB1_26743006_Chip-Seq_LNCaP_Human0.80746283
119SMC4_20622854_ChIP-Seq_HELA_Human0.80117861
120E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.79133422
121OCT4_19829295_ChIP-Seq_ESCs_Human0.78562095
122DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.75655188
123PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.75303664
124SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.74670261
125ISL1_27105846_Chip-Seq_CPCs_Mouse0.74039739
126KLF4_19829295_ChIP-Seq_ESCs_Human0.73981666
127POU5F1_16518401_ChIP-PET_MESCs_Mouse0.73394724
128SMAD4_21741376_ChIP-Seq_ESCs_Human0.71746043
129LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.71309883

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.42664496
2MP0003880_abnormal_central_pattern4.13033241
3MP0003635_abnormal_synaptic_transmissio3.73395256
4MP0004270_analgesia3.54385146
5MP0009745_abnormal_behavioral_response3.07104971
6MP0002063_abnormal_learning/memory/cond3.00119012
7MP0001968_abnormal_touch/_nociception2.82706540
8MP0002064_seizures2.77996144
9MP0002734_abnormal_mechanical_nocicepti2.69915634
10MP0009046_muscle_twitch2.61906609
11MP0002572_abnormal_emotion/affect_behav2.61710070
12MP0005423_abnormal_somatic_nervous2.54942822
13MP0002735_abnormal_chemical_nociception2.43338899
14MP0002272_abnormal_nervous_system2.42079941
15MP0002822_catalepsy2.41655119
16MP0002733_abnormal_thermal_nociception2.36265049
17MP0002736_abnormal_nociception_after2.28621757
18MP0006276_abnormal_autonomic_nervous2.25842713
19MP0001970_abnormal_pain_threshold2.14488864
20MP0001486_abnormal_startle_reflex2.13755809
21MP0009780_abnormal_chondrocyte_physiolo2.09194721
22MP0001440_abnormal_grooming_behavior2.06398741
23MP0002184_abnormal_innervation2.02024515
24MP0001501_abnormal_sleep_pattern1.88956302
25MP0003122_maternal_imprinting1.88445292
26MP0004858_abnormal_nervous_system1.87760686
27MP0000778_abnormal_nervous_system1.85575200
28MP0002909_abnormal_adrenal_gland1.84024346
29MP0002067_abnormal_sensory_capabilities1.81071664
30MP0002557_abnormal_social/conspecific_i1.78804983
31MP0004811_abnormal_neuron_physiology1.68220485
32MP0005645_abnormal_hypothalamus_physiol1.66802925
33MP0004924_abnormal_behavior1.66719144
34MP0005386_behavior/neurological_phenoty1.66719144
35MP0005646_abnormal_pituitary_gland1.63872078
36MP0000955_abnormal_spinal_cord1.63520032
37MP0001529_abnormal_vocalization1.62859205
38MP0003879_abnormal_hair_cell1.56496560
39MP0001188_hyperpigmentation1.55034017
40MP0008569_lethality_at_weaning1.51305505
41MP0004142_abnormal_muscle_tone1.47906763
42MP0003787_abnormal_imprinting1.45101339
43MP0001905_abnormal_dopamine_level1.43194537
44MP0003283_abnormal_digestive_organ1.42438288
45MP0010386_abnormal_urinary_bladder1.42233636
46MP0003329_amyloid_beta_deposits1.41808172
47MP0002882_abnormal_neuron_morphology1.41273294
48MP0002066_abnormal_motor_capabilities/c1.35300749
49MP0003690_abnormal_glial_cell1.31272348
50MP0001984_abnormal_olfaction1.28142225
51MP0000566_synostosis1.26840620
52MP0005394_taste/olfaction_phenotype1.26261084
53MP0005499_abnormal_olfactory_system1.26261084
54MP0000920_abnormal_myelination1.25337088
55MP0008877_abnormal_DNA_methylation1.22041851
56MP0000631_abnormal_neuroendocrine_gland1.19794856
57MP0004885_abnormal_endolymph1.19487715
58MP0001502_abnormal_circadian_rhythm1.17623234
59MP0002152_abnormal_brain_morphology1.14995650
60MP0001346_abnormal_lacrimal_gland1.09694924
61MP0000639_abnormal_adrenal_gland1.09248740
62MP0006072_abnormal_retinal_apoptosis1.09185423
63MP0003123_paternal_imprinting1.06867488
64MP0002638_abnormal_pupillary_reflex1.06630394
65MP0002837_dystrophic_cardiac_calcinosis0.99934148
66MP0002751_abnormal_autonomic_nervous0.97768704
67MP0003633_abnormal_nervous_system0.97515693
68MP0002229_neurodegeneration0.97064906
69MP0004043_abnormal_pH_regulation0.95099477
70MP0000579_abnormal_nail_morphology0.93340344
71MP0002876_abnormal_thyroid_physiology0.92849050
72MP0000604_amyloidosis0.91626051
73MP0001963_abnormal_hearing_physiology0.91576036
74MP0002752_abnormal_somatic_nervous0.91444505
75MP0000013_abnormal_adipose_tissue0.90044363
76MP0001485_abnormal_pinna_reflex0.89710756
77MP0000678_abnormal_parathyroid_gland0.87278205
78MP0003631_nervous_system_phenotype0.87181701
79MP0004085_abnormal_heartbeat0.86332750
80MP0002069_abnormal_eating/drinking_beha0.85213948
81MP0003121_genomic_imprinting0.84990678
82MP0003119_abnormal_digestive_system0.84819213
83MP0000537_abnormal_urethra_morphology0.84137275
84MP0001664_abnormal_digestion0.82821714
85MP0004233_abnormal_muscle_weight0.81762567
86MP0003890_abnormal_embryonic-extraembry0.81243218
87MP0004133_heterotaxia0.80860119
88MP0004742_abnormal_vestibular_system0.79972612
89MP0003634_abnormal_glial_cell0.79046530
90MP0003861_abnormal_nervous_system0.79000640
91MP0005551_abnormal_eye_electrophysiolog0.78887742
92MP0003938_abnormal_ear_development0.78233369
93MP0005623_abnormal_meninges_morphology0.77576776
94MP0008789_abnormal_olfactory_epithelium0.77525183
95MP0003315_abnormal_perineum_morphology0.77144561
96MP0001348_abnormal_lacrimal_gland0.76876416
97MP0002102_abnormal_ear_morphology0.73927531
98MP0006292_abnormal_olfactory_placode0.73172531
99MP0001986_abnormal_taste_sensitivity0.72333532
100MP0005535_abnormal_body_temperature0.70956059
101MP0002090_abnormal_vision0.70546533
102MP0008872_abnormal_physiological_respon0.70414020
103MP0005187_abnormal_penis_morphology0.69769094
104MP0003183_abnormal_peptide_metabolism0.68678930
105MP0002234_abnormal_pharynx_morphology0.68007955
106MP0001299_abnormal_eye_distance/0.67995572
107MP0005410_abnormal_fertilization0.67880653
108MP0008874_decreased_physiological_sensi0.67832623
109MP0002160_abnormal_reproductive_system0.65309664
110MP0001177_atelectasis0.65241860
111MP0000751_myopathy0.63665027
112MP0002249_abnormal_larynx_morphology0.63464587
113MP0003632_abnormal_nervous_system0.63201498
114MP0000026_abnormal_inner_ear0.62519907
115MP0010769_abnormal_survival0.60738130
116MP0003137_abnormal_impulse_conducting0.60116269
117MP0010768_mortality/aging0.58485496
118MP0008995_early_reproductive_senescence0.57940551
119MP0003075_altered_response_to0.55765211
120MP0000462_abnormal_digestive_system0.55528752
121MP0002082_postnatal_lethality0.55470946
122MP0010770_preweaning_lethality0.55470946
123MP0009672_abnormal_birth_weight0.53625774
124MP0001943_abnormal_respiration0.50455677
125MP0002081_perinatal_lethality0.48682569

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.29529426
2Focal motor seizures (HP:0011153)5.74037692
3Visual hallucinations (HP:0002367)5.29457974
4Focal seizures (HP:0007359)4.38225779
5Epileptic encephalopathy (HP:0200134)4.27004867
6Atonic seizures (HP:0010819)4.17985054
7Absence seizures (HP:0002121)3.73928015
8Progressive cerebellar ataxia (HP:0002073)3.71631937
9Generalized tonic-clonic seizures (HP:0002069)3.44092385
10Amblyopia (HP:0000646)3.36369632
11Febrile seizures (HP:0002373)3.34956153
12Limb dystonia (HP:0002451)3.26887906
13Dialeptic seizures (HP:0011146)3.24631446
14Ankle clonus (HP:0011448)3.16462240
15Supranuclear gaze palsy (HP:0000605)3.07009272
16Aplasia involving bones of the extremities (HP:0009825)2.91750423
17Aplasia involving bones of the upper limbs (HP:0009823)2.91750423
18Aplasia of the phalanges of the hand (HP:0009802)2.91750423
19Hyperventilation (HP:0002883)2.87420868
20Broad-based gait (HP:0002136)2.86428044
21Pheochromocytoma (HP:0002666)2.84646909
22Action tremor (HP:0002345)2.83763544
23Obstructive sleep apnea (HP:0002870)2.79215800
24Mutism (HP:0002300)2.76664965
25Depression (HP:0000716)2.75956410
26Annular pancreas (HP:0001734)2.75758246
27Focal dystonia (HP:0004373)2.73652395
28Epileptiform EEG discharges (HP:0011182)2.70753060
29Gaze-evoked nystagmus (HP:0000640)2.63798544
30Intention tremor (HP:0002080)2.62164523
31EEG with generalized epileptiform discharges (HP:0011198)2.61704658
32Gait imbalance (HP:0002141)2.59200414
33Bronchomalacia (HP:0002780)2.58634506
34Anxiety (HP:0000739)2.57335286
35Status epilepticus (HP:0002133)2.57240318
36Poor eye contact (HP:0000817)2.57089579
37Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.56413342
38Neuroendocrine neoplasm (HP:0100634)2.55851937
39Impaired vibration sensation in the lower limbs (HP:0002166)2.55400640
40Renal salt wasting (HP:0000127)2.52577709
41Hypsarrhythmia (HP:0002521)2.51504425
42Craniofacial dystonia (HP:0012179)2.49735263
43Sleep apnea (HP:0010535)2.49308178
44Cerebral hypomyelination (HP:0006808)2.48969985
45Drooling (HP:0002307)2.48709827
46Excessive salivation (HP:0003781)2.48709827
47Dysdiadochokinesis (HP:0002075)2.46658666
48Truncal ataxia (HP:0002078)2.46042423
49Neuronal loss in central nervous system (HP:0002529)2.45152702
50Split foot (HP:0001839)2.42356271
51Absent speech (HP:0001344)2.42104072
52Agitation (HP:0000713)2.40946145
53Tetraplegia (HP:0002445)2.40823090
54Urinary bladder sphincter dysfunction (HP:0002839)2.38434130
55Amyotrophic lateral sclerosis (HP:0007354)2.35913621
56Progressive inability to walk (HP:0002505)2.34153087
57Abnormal eating behavior (HP:0100738)2.32992569
58Impaired smooth pursuit (HP:0007772)2.32884975
59Retinal dysplasia (HP:0007973)2.32405668
60Hemiplegia (HP:0002301)2.30678871
61Bradykinesia (HP:0002067)2.29516157
62Poor suck (HP:0002033)2.29397134
63Dysmetria (HP:0001310)2.28361492
64Turricephaly (HP:0000262)2.27940991
65Polyphagia (HP:0002591)2.25959261
66Abnormal social behavior (HP:0012433)2.24697604
67Impaired social interactions (HP:0000735)2.24697604
68Cerebral inclusion bodies (HP:0100314)2.23659692
69Aplasia/Hypoplasia of the brainstem (HP:0007362)2.23585896
70Hypoplasia of the brainstem (HP:0002365)2.23585896
71Abnormality of the corticospinal tract (HP:0002492)2.23499613
72Papilledema (HP:0001085)2.22809075
73Insomnia (HP:0100785)2.22566353
74Spastic gait (HP:0002064)2.22264056
75Urinary urgency (HP:0000012)2.22081410
76Hemiparesis (HP:0001269)2.21270349
77Delusions (HP:0000746)2.21016403
78Postural instability (HP:0002172)2.18215416
79Dysmetric saccades (HP:0000641)2.17323989
80Abnormality of the lower motor neuron (HP:0002366)2.17205041
81Failure to thrive in infancy (HP:0001531)2.17159111
82Medial flaring of the eyebrow (HP:0010747)2.15714320
83Ventricular fibrillation (HP:0001663)2.15712824
84Genetic anticipation (HP:0003743)2.14516473
85Inability to walk (HP:0002540)2.13015217
86Rigidity (HP:0002063)2.11328383
87Apathy (HP:0000741)2.10339222
88Congenital primary aphakia (HP:0007707)2.08868476
89Termporal pattern (HP:0011008)2.06956242
90Insidious onset (HP:0003587)2.06956242
91Impaired vibratory sensation (HP:0002495)2.01436224
92Thickened helices (HP:0000391)1.99679849
93Abnormality of calcium-phosphate metabolism (HP:0100530)1.99379424
94Hyperaldosteronism (HP:0000859)1.97342636
95Absent/shortened dynein arms (HP:0200106)1.97062834
96Dynein arm defect of respiratory motile cilia (HP:0012255)1.97062834
97Abnormality of ocular smooth pursuit (HP:0000617)1.95557666
98Specific learning disability (HP:0001328)1.94104515
99Morphological abnormality of the pyramidal tract (HP:0002062)1.93883582
100Genital tract atresia (HP:0001827)1.91267883
101Nephrogenic diabetes insipidus (HP:0009806)1.90645728
102Choreoathetosis (HP:0001266)1.90507090
103Diminished motivation (HP:0000745)1.90332205
104Spastic tetraparesis (HP:0001285)1.90292647
105Neoplasm of the peripheral nervous system (HP:0100007)1.88538321
106Lower limb asymmetry (HP:0100559)1.88359838
107Hypothermia (HP:0002045)1.88086722
108Incomplete penetrance (HP:0003829)1.87141996
109Megalencephaly (HP:0001355)1.86401916
110Vaginal atresia (HP:0000148)1.85391571
111Generalized myoclonic seizures (HP:0002123)1.85211288
112Abnormal hair whorl (HP:0010721)1.85090538
113Choanal stenosis (HP:0000452)1.84364985
114Syncope (HP:0001279)1.83440613
115Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.80938567
116Degeneration of the lateral corticospinal tracts (HP:0002314)1.80938567
117Cutaneous finger syndactyly (HP:0010554)1.80272449
118Type II lissencephaly (HP:0007260)1.79648809
119Lissencephaly (HP:0001339)1.75617247
120Hyperthyroidism (HP:0000836)1.74358801
121Prolonged QT interval (HP:0001657)1.74060790
122Psychosis (HP:0000709)1.73057148
123Fetal akinesia sequence (HP:0001989)1.71872159
124Peripheral hypomyelination (HP:0007182)1.71100201
125Torticollis (HP:0000473)1.70562187
126Abnormality of the labia minora (HP:0012880)1.70425113
127Lower limb muscle weakness (HP:0007340)1.69937955
128Akinesia (HP:0002304)1.68887665
129Testicular neoplasm (HP:0010788)1.68433378
130Neurofibrillary tangles (HP:0002185)1.68278161
131Resting tremor (HP:0002322)1.67526876
132Stereotypic behavior (HP:0000733)1.67524469
133Diplopia (HP:0000651)1.67423991
134Abnormality of binocular vision (HP:0011514)1.67423991
135Increased circulating renin level (HP:0000848)1.67059110
136Gait ataxia (HP:0002066)1.66877988
137Cutaneous syndactyly (HP:0012725)1.66833155
138Protruding tongue (HP:0010808)1.66816690
139Abnormal EKG (HP:0003115)1.66633634
140Scanning speech (HP:0002168)1.66526945
141Hypoventilation (HP:0002791)1.65782910
142Clonus (HP:0002169)1.64710956
143Gastroesophageal reflux (HP:0002020)1.64012252

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.43537923
2PRKD34.02968857
3MARK13.85543975
4MINK13.18382772
5MAP3K93.11206897
6EPHA43.10998857
7MAP3K122.69218422
8MAP3K42.67070460
9CASK2.39939129
10MAP2K72.34774278
11GRK52.18850491
12NTRK22.06438213
13DAPK21.99940325
14NTRK11.96836463
15PLK21.89984718
16MAPK131.88066996
17PNCK1.77781411
18PAK61.71881635
19MAP2K41.66014105
20DAPK11.62226523
21KSR21.60174951
22UHMK11.43540212
23CDK51.42365869
24LATS21.39041306
25NME11.33322239
26KSR11.31669506
27MAP3K21.24919389
28PRKCG1.19387077
29FGFR21.18946406
30CAMKK11.15612219
31SIK21.12830657
32DYRK1A1.11193490
33RIPK41.10466828
34TYRO31.05042308
35RIPK11.03611496
36ARAF1.02295354
37PDK30.97381683
38PDK40.97381683
39CAMK2A0.96278055
40SCYL20.95012185
41CDK140.94513425
42LMTK20.89496078
43PHKG10.88855309
44PHKG20.88855309
45SGK30.88788640
46CDK180.88504589
47PAK30.88002818
48CDK190.86804559
49CAMK2B0.86284187
50PRPF4B0.84847510
51CDK150.84284118
52AKT30.83128479
53STK380.82217166
54MAPK120.82140684
55TNIK0.81226581
56BRAF0.80919899
57WNK30.78654350
58MAP3K110.78456978
59CAMKK20.76158007
60CSNK1G20.75807395
61PTK2B0.75711477
62CDK11A0.74872936
63DAPK30.73855275
64WNK40.71852056
65BMPR20.70966902
66CDC42BPA0.70833322
67DYRK20.70818159
68NEK60.70199004
69CAMK40.69251749
70PRKCH0.69111160
71CAMK1G0.68393999
72LIMK10.63848504
73ALK0.63305795
74SGK4940.61408220
75SGK2230.61408220
76FRK0.60918651
77PKN10.60646133
78BCR0.60611893
79FES0.60516474
80RET0.60270683
81SIK30.60238152
82MAPK100.60159263
83PRKCE0.59830363
84MAP3K130.59768862
85STK110.59063096
86CAMK10.57281841
87FER0.54743929
88CAMK2D0.54248479
89CAMK1D0.54189292
90RPS6KA20.54098508
91PLK30.53231577
92TAF10.52244295
93PRKCZ0.51077402
94TSSK60.50600891
95ERBB30.50330129
96ADRBK10.49297633
97PDPK10.49182957
98WNK10.48486663
99MARK20.46076453
100MAP2K10.45532731
101INSRR0.45409034
102GRK70.44987823
103PRKG20.44060531
104CSNK1G10.43793880
105PINK10.42726512
106SGK10.42699274
107NEK10.42548170
108OXSR10.42521198
109ICK0.41907263
110SGK20.41378431
111CAMK2G0.40978211
112BRSK10.39279720
113FGR0.39184961
114CSNK1G30.38917741
115ROCK20.38132613
116MAPKAPK50.37465158
117MAP3K10.37457527
118CSNK1A1L0.37438808
119PDK10.37196353
120PRKCI0.37158725
121TNK20.34726789
122RPS6KA30.34613739
123CSNK1E0.29424780
124RPS6KB10.28126517
125FYN0.28109979
126BMX0.28043544
127RAF10.27996847
128MAP2K60.27607712
129IRAK20.27336322

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.73072527
2Nicotine addiction_Homo sapiens_hsa050333.67514925
3Long-term potentiation_Homo sapiens_hsa047202.72984754
4GABAergic synapse_Homo sapiens_hsa047272.62939174
5Olfactory transduction_Homo sapiens_hsa047402.58691341
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.57994490
7Circadian entrainment_Homo sapiens_hsa047132.56985278
8Amphetamine addiction_Homo sapiens_hsa050312.56653511
9Morphine addiction_Homo sapiens_hsa050322.37878986
10Glutamatergic synapse_Homo sapiens_hsa047242.33842140
11Dopaminergic synapse_Homo sapiens_hsa047282.30650039
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.28880088
13Insulin secretion_Homo sapiens_hsa049112.19371273
14Collecting duct acid secretion_Homo sapiens_hsa049662.13598894
15Vitamin B6 metabolism_Homo sapiens_hsa007502.09917951
16Taste transduction_Homo sapiens_hsa047421.93401845
17Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.91966226
18Serotonergic synapse_Homo sapiens_hsa047261.89892145
19Cholinergic synapse_Homo sapiens_hsa047251.88624775
20Cocaine addiction_Homo sapiens_hsa050301.85238051
21Salivary secretion_Homo sapiens_hsa049701.81797716
22Vibrio cholerae infection_Homo sapiens_hsa051101.78569922
23Long-term depression_Homo sapiens_hsa047301.64615640
24Renin secretion_Homo sapiens_hsa049241.60101281
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.59921130
26Gastric acid secretion_Homo sapiens_hsa049711.56550415
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.48584399
28Oxytocin signaling pathway_Homo sapiens_hsa049211.45195406
29Gap junction_Homo sapiens_hsa045401.42792801
30Calcium signaling pathway_Homo sapiens_hsa040201.41642833
31Oxidative phosphorylation_Homo sapiens_hsa001901.35188790
32Oocyte meiosis_Homo sapiens_hsa041141.29072713
33Cardiac muscle contraction_Homo sapiens_hsa042601.25703875
34Parkinsons disease_Homo sapiens_hsa050121.21251905
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.18785007
36Axon guidance_Homo sapiens_hsa043601.16585219
37Estrogen signaling pathway_Homo sapiens_hsa049151.12776284
38GnRH signaling pathway_Homo sapiens_hsa049121.12538902
39Alzheimers disease_Homo sapiens_hsa050101.10896381
40Melanogenesis_Homo sapiens_hsa049161.09316348
41Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.08825044
42cAMP signaling pathway_Homo sapiens_hsa040241.08185522
43Type II diabetes mellitus_Homo sapiens_hsa049301.04827276
44Glioma_Homo sapiens_hsa052141.02391694
45Phosphatidylinositol signaling system_Homo sapiens_hsa040700.99574962
46Pancreatic secretion_Homo sapiens_hsa049720.98630222
47Ovarian steroidogenesis_Homo sapiens_hsa049130.96623919
48Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.94591922
49cGMP-PKG signaling pathway_Homo sapiens_hsa040220.92951969
50ErbB signaling pathway_Homo sapiens_hsa040120.92142065
51Bile secretion_Homo sapiens_hsa049760.90879934
52Phototransduction_Homo sapiens_hsa047440.90417186
53Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.90242613
54Huntingtons disease_Homo sapiens_hsa050160.82396171
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81206377
56Alcoholism_Homo sapiens_hsa050340.81062557
57Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.76632391
58Vascular smooth muscle contraction_Homo sapiens_hsa042700.74908124
59Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.73423497
60Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.72521221
61Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.71781933
62Thyroid hormone synthesis_Homo sapiens_hsa049180.67539382
63Type I diabetes mellitus_Homo sapiens_hsa049400.65958643
64Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.64501175
65Dorso-ventral axis formation_Homo sapiens_hsa043200.63873348
66Wnt signaling pathway_Homo sapiens_hsa043100.63537866
67Protein export_Homo sapiens_hsa030600.63248272
68Phospholipase D signaling pathway_Homo sapiens_hsa040720.60604825
69Carbohydrate digestion and absorption_Homo sapiens_hsa049730.59581033
70Glucagon signaling pathway_Homo sapiens_hsa049220.59514115
71Maturity onset diabetes of the young_Homo sapiens_hsa049500.59116922
72Ras signaling pathway_Homo sapiens_hsa040140.58949355
73MAPK signaling pathway_Homo sapiens_hsa040100.58793528
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.58421091
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57127612
76Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56799319
77Choline metabolism in cancer_Homo sapiens_hsa052310.56215467
78Prion diseases_Homo sapiens_hsa050200.54973569
79Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54785461
80Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.52612828
81Tight junction_Homo sapiens_hsa045300.52257187
82Arginine and proline metabolism_Homo sapiens_hsa003300.51737392
83Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51526451
84Hippo signaling pathway_Homo sapiens_hsa043900.51399604
85VEGF signaling pathway_Homo sapiens_hsa043700.50150396
86Rap1 signaling pathway_Homo sapiens_hsa040150.49681947
87Endometrial cancer_Homo sapiens_hsa052130.47129503
88Inositol phosphate metabolism_Homo sapiens_hsa005620.45596084
89Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45564840
90mTOR signaling pathway_Homo sapiens_hsa041500.45284997
91Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.44632045
92Hedgehog signaling pathway_Homo sapiens_hsa043400.44601555
93Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43601743
94Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.42747183
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42489413
96Arginine biosynthesis_Homo sapiens_hsa002200.39537938
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.39158724
98Insulin signaling pathway_Homo sapiens_hsa049100.38596359
99Dilated cardiomyopathy_Homo sapiens_hsa054140.36922145
100Endocytosis_Homo sapiens_hsa041440.36005857
101Sphingolipid signaling pathway_Homo sapiens_hsa040710.35734969
102beta-Alanine metabolism_Homo sapiens_hsa004100.34817565
103Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.34259073
104Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.34140027
105Colorectal cancer_Homo sapiens_hsa052100.34137366
106Melanoma_Homo sapiens_hsa052180.33683727
107N-Glycan biosynthesis_Homo sapiens_hsa005100.32612439
108Circadian rhythm_Homo sapiens_hsa047100.32359085
109AMPK signaling pathway_Homo sapiens_hsa041520.32123771
110Renal cell carcinoma_Homo sapiens_hsa052110.30922695
111Non-small cell lung cancer_Homo sapiens_hsa052230.30067701
112Central carbon metabolism in cancer_Homo sapiens_hsa052300.29507588
113Histidine metabolism_Homo sapiens_hsa003400.27643927
114Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.25411237
115Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.24893004
116Mineral absorption_Homo sapiens_hsa049780.23982931
117Folate biosynthesis_Homo sapiens_hsa007900.23903699
118Basal cell carcinoma_Homo sapiens_hsa052170.20482227

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