ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	synaptic vesicle maturation (GO:0016188)	8.14740323
2	synaptic vesicle docking involved in exocytosis (GO:0016081)	8.13250424
3	glutamate secretion (GO:0014047)	7.54912133
4	regulation of short-term neuronal synaptic plasticity (GO:0048172)	7.10823158
5	synaptic vesicle exocytosis (GO:0016079)	6.57273926
6	regulation of synaptic vesicle exocytosis (GO:2000300)	6.38580873
7	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	5.75535446
8	regulation of synaptic vesicle transport (GO:1902803)	5.73669019
9	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	5.49515448
10	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	5.46552230
11	cellular potassium ion homeostasis (GO:0030007)	5.45152652
12	neurotransmitter secretion (GO:0007269)	5.29239664
13	regulation of neuronal synaptic plasticity (GO:0048168)	5.17910786
14	locomotory exploration behavior (GO:0035641)	5.07154724
15	sodium ion export (GO:0071436)	4.98855459
16	exploration behavior (GO:0035640)	4.82717748
17	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	4.79440622
18	vocalization behavior (GO:0071625)	4.70050933
19	ionotropic glutamate receptor signaling pathway (GO:0035235)	4.58819176
20	regulation of long-term neuronal synaptic plasticity (GO:0048169)	4.53673299
21	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	4.47282207
22	L-amino acid import (GO:0043092)	4.42993120
23	positive regulation of synapse maturation (GO:0090129)	4.37796409
24	neurotransmitter transport (GO:0006836)	4.30142324
25	protein localization to synapse (GO:0035418)	4.26409037
26	cell communication by electrical coupling involved in cardiac conduction (GO:0086064)	4.25597310
27	neuronal action potential propagation (GO:0019227)	4.23671940
28	synaptic transmission, glutamatergic (GO:0035249)	4.19207070
29	cerebellar granule cell differentiation (GO:0021707)	4.18725118
30	negative regulation of synaptic transmission, GABAergic (GO:0032229)	4.16051041
31	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act	4.16038812
32	positive regulation of dendritic spine morphogenesis (GO:0061003)	4.11516164
33	regulation of synapse structural plasticity (GO:0051823)	4.10507573
34	regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)	4.08567204
35	positive regulation of dendritic spine development (GO:0060999)	4.06544532
36	regulation of glutamate receptor signaling pathway (GO:1900449)	4.06118844
37	dendritic spine morphogenesis (GO:0060997)	4.03583640
38	regulation of neurotransmitter secretion (GO:0046928)	4.02756638
39	mating behavior (GO:0007617)	4.00157701
40	amino acid import (GO:0043090)	3.96041928
41	central nervous system myelination (GO:0022010)	3.92892614
42	axon ensheathment in central nervous system (GO:0032291)	3.92892614
43	neuron-neuron synaptic transmission (GO:0007270)	3.88425640
44	regulation of excitatory postsynaptic membrane potential (GO:0060079)	3.87465484
45	neuronal ion channel clustering (GO:0045161)	3.87172639
46	regulation of voltage-gated calcium channel activity (GO:1901385)	3.86874444
47	regulation of neurotransmitter levels (GO:0001505)	3.86017697
48	regulation of synaptic plasticity (GO:0048167)	3.85081577
49	positive regulation of membrane potential (GO:0045838)	3.82280918
50	neuromuscular process controlling balance (GO:0050885)	3.81650305
51	neuron cell-cell adhesion (GO:0007158)	3.81385357
52	synaptic vesicle endocytosis (GO:0048488)	3.81056295
53	cell communication by electrical coupling (GO:0010644)	3.78682230
54	potassium ion import (GO:0010107)	3.75615368
55	postsynaptic membrane organization (GO:0001941)	3.75398386
56	layer formation in cerebral cortex (GO:0021819)	3.74792645
57	potassium ion homeostasis (GO:0055075)	3.72376152
58	negative regulation of dendrite morphogenesis (GO:0050774)	3.69003756
59	positive regulation of neurotransmitter transport (GO:0051590)	3.64522136
60	regulation of postsynaptic membrane potential (GO:0060078)	3.64271146
61	glutamate receptor signaling pathway (GO:0007215)	3.64013560
62	regulation of dendritic spine morphogenesis (GO:0061001)	3.63889259
63	neurotransmitter-gated ion channel clustering (GO:0072578)	3.63577999
64	regulation of neurotransmitter transport (GO:0051588)	3.63171424
65	regulation of synapse maturation (GO:0090128)	3.55157719
66	positive regulation of neurotransmitter secretion (GO:0001956)	3.53350463
67	regulation of vesicle fusion (GO:0031338)	3.50829196
68	cerebellar Purkinje cell differentiation (GO:0021702)	3.48151897
69	long-term memory (GO:0007616)	3.37023405
70	cellular sodium ion homeostasis (GO:0006883)	3.36768552
71	regulation of dendritic spine development (GO:0060998)	3.33898661
72	gamma-aminobutyric acid signaling pathway (GO:0007214)	3.32305866
73	cell migration in hindbrain (GO:0021535)	3.31772243
74	dendritic spine organization (GO:0097061)	3.31645483
75	response to insecticide (GO:0017085)	3.30480830
76	membrane depolarization during action potential (GO:0086010)	3.29529945
77	membrane depolarization (GO:0051899)	3.24634963
78	gamma-aminobutyric acid transport (GO:0015812)	3.24179544
79	regulation of ARF protein signal transduction (GO:0032012)	3.21811063
80	G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)	3.17082715
81	neuromuscular synaptic transmission (GO:0007274)	3.15429309
82	regulation of synaptic transmission (GO:0050804)	3.11882014
83	proline transport (GO:0015824)	3.11279392
84	activation of protein kinase A activity (GO:0034199)	3.07598801
85	transmission of nerve impulse (GO:0019226)	3.06607639
86	cytoskeletal anchoring at plasma membrane (GO:0007016)	3.04859086
87	establishment of synaptic vesicle localization (GO:0097480)	3.04673682
88	synaptic vesicle transport (GO:0048489)	3.04673682
89	cell communication involved in cardiac conduction (GO:0086065)	3.04099950
90	social behavior (GO:0035176)	3.02836640
91	intraspecies interaction between organisms (GO:0051703)	3.02836640
92	acidic amino acid transport (GO:0015800)	3.01295540
93	synaptic transmission (GO:0007268)	3.01270184
94	positive regulation of dendrite development (GO:1900006)	2.98722606
95	neuromuscular process (GO:0050905)	2.96210615
96	neuromuscular process controlling posture (GO:0050884)	2.95954954
97	regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)	2.94594659
98	chemosensory behavior (GO:0007635)	2.93676454
99	presynaptic membrane organization (GO:0097090)	2.93273319
100	behavioral response to cocaine (GO:0048148)	2.90772314

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.50029257
2	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	3.91070358
3	REST_21632747_ChIP-Seq_MESCs_Mouse	3.18827897
4	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	3.18525966
5	JARID2_20064375_ChIP-Seq_MESCs_Mouse	3.17344231
6	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	3.11938595
7	RARB_27405468_Chip-Seq_BRAIN_Mouse	2.99089764
8	RNF2_18974828_ChIP-Seq_MESCs_Mouse	2.89982188
9	EZH2_18974828_ChIP-Seq_MESCs_Mouse	2.89982188
10	DROSHA_22980978_ChIP-Seq_HELA_Human	2.89188267
11	JARID2_20075857_ChIP-Seq_MESCs_Mouse	2.83550744
12	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	2.78270662
13	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.77536557
14	MTF2_20144788_ChIP-Seq_MESCs_Mouse	2.72243534
15	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	2.69820993
16	REST_18959480_ChIP-ChIP_MESCs_Mouse	2.67868579
17	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.61834683
18	RNF2_27304074_Chip-Seq_ESCs_Mouse	2.59948917
19	EZH2_27294783_Chip-Seq_ESCs_Mouse	2.56532230
20	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	2.54796957
21	SUZ12_27294783_Chip-Seq_ESCs_Mouse	2.53322274
22	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	2.53230419
23	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	2.41894571
24	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	2.37964410
25	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	2.33246933
26	GBX2_23144817_ChIP-Seq_PC3_Human	2.33030792
27	EED_16625203_ChIP-ChIP_MESCs_Mouse	2.27770809
28	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	2.16585269
29	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	2.12895248
30	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.96882669
31	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	1.85674753
32	ZFP281_18757296_ChIP-ChIP_E14_Mouse	1.83213510
33	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.78634814
34	KDM2B_26808549_Chip-Seq_K562_Human	1.69858783
35	AR_21572438_ChIP-Seq_LNCaP_Human	1.55226395
36	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.53998641
37	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.51560104
38	CTCF_27219007_Chip-Seq_Bcells_Human	1.44876615
39	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.43606317
40	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	1.33678319
41	ZFP281_27345836_Chip-Seq_ESCs_Mouse	1.32638234
42	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.30558667
43	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.29142845
44	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.28872148
45	TET1_21490601_ChIP-Seq_MESCs_Mouse	1.27301063
46	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	1.26412217
47	NR3C1_23031785_ChIP-Seq_PC12_Mouse	1.23730918
48	RING1B_27294783_Chip-Seq_NPCs_Mouse	1.23435496
49	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.21901600
50	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.21250645
51	WT1_25993318_ChIP-Seq_PODOCYTE_Human	1.20768112
52	OLIG2_26023283_ChIP-Seq_AINV15_Mouse	1.18461863
53	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.18172816
54	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.15687746
55	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.15243163
56	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.14526966
57	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.11495820
58	AR_19668381_ChIP-Seq_PC3_Human	1.10171971
59	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.08824210
60	RNF2_27304074_Chip-Seq_NSC_Mouse	1.08624322
61	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.06859095
62	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.04446171
63	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.01149226
64	TCF3_18467660_ChIP-ChIP_MESCs_Mouse	0.99103389
65	SRY_22984422_ChIP-ChIP_TESTIS_Rat	0.98562991
66	YAP1_20516196_ChIP-Seq_MESCs_Mouse	0.98391604
67	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.97841231
68	ESR2_21235772_ChIP-Seq_MCF-7_Human	0.94526020
69	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.94087003
70	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.93312130
71	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.92429476
72	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.91699119
73	OCT4_19829295_ChIP-Seq_ESCs_Human	0.91591835
74	LXR_22292898_ChIP-Seq_THP-1_Human	0.91183890
75	SMAD4_21799915_ChIP-Seq_A2780_Human	0.90469339
76	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.89022026
77	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.89022026
78	SMC4_20622854_ChIP-Seq_HELA_Human	0.88573060
79	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.86884046
80	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.86503905
81	GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.85944847
82	KLF4_19829295_ChIP-Seq_ESCs_Human	0.82597594
83	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	0.82161388
84	KDM2B_26808549_Chip-Seq_SUP-B15_Human	0.81884247
85	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	0.81296791
86	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.79725549
87	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.79615961
88	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.79517398
89	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.79453734
90	DPY_21335234_ChIP-Seq_ESCs_Mouse	0.79409393
91	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.78932327
92	EP300_21415370_ChIP-Seq_HL-1_Mouse	0.76462397
93	CTNNB1_20460455_ChIP-Seq_HCT116_Human	0.76264937
94	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.73738880
95	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.73597715
96	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.73479891
97	CREB1_26743006_Chip-Seq_LNCaP_Human	0.71741984
98	DMRT1_23473982_ChIP-Seq_TESTES_Mouse	0.71535276
99	SOX9_26525672_Chip-Seq_HEART_Mouse	0.71282255
100	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	0.70429179

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004859_abnormal_synaptic_plasticity	6.93992903
2	MP0003880_abnormal_central_pattern	5.21742879
3	MP0004270_analgesia	4.29410291
4	MP0003635_abnormal_synaptic_transmissio	4.10006203
5	MP0005423_abnormal_somatic_nervous	3.68861074
6	MP0002064_seizures	3.57771971
7	MP0009745_abnormal_behavioral_response	3.28199205
8	MP0002063_abnormal_learning/memory/cond	3.25240083
9	MP0009046_muscle_twitch	2.92708750
10	MP0002272_abnormal_nervous_system	2.91296636
11	MP0002734_abnormal_mechanical_nocicepti	2.81872040
12	MP0001486_abnormal_startle_reflex	2.81172265
13	MP0002572_abnormal_emotion/affect_behav	2.72141703
14	MP0001968_abnormal_touch/_nociception	2.70805373
15	MP0003329_amyloid_beta_deposits	2.28177875
16	MP0003879_abnormal_hair_cell	2.26853937
17	MP0001501_abnormal_sleep_pattern	2.23729395
18	MP0008569_lethality_at_weaning	2.10877461
19	MP0002736_abnormal_nociception_after	1.97097730
20	MP0002735_abnormal_chemical_nociception	1.96814339
21	MP0003122_maternal_imprinting	1.92444916
22	MP0001970_abnormal_pain_threshold	1.86147914
23	MP0003787_abnormal_imprinting	1.82891812
24	MP0004811_abnormal_neuron_physiology	1.81039748
25	MP0003123_paternal_imprinting	1.69908697
26	MP0002733_abnormal_thermal_nociception	1.69100389
27	MP0004885_abnormal_endolymph	1.67235452
28	MP0002067_abnormal_sensory_capabilities	1.65271788
29	MP0000778_abnormal_nervous_system	1.64883702
30	MP0001905_abnormal_dopamine_level	1.63621307
31	MP0002557_abnormal_social/conspecific_i	1.61453108
32	MP0001440_abnormal_grooming_behavior	1.60808855
33	MP0009780_abnormal_chondrocyte_physiolo	1.58527161
34	MP0006276_abnormal_autonomic_nervous	1.54134359
35	MP0001177_atelectasis	1.53489072
36	MP0003633_abnormal_nervous_system	1.53371143
37	MP0001984_abnormal_olfaction	1.49799262
38	MP0002066_abnormal_motor_capabilities/c	1.48280384
39	MP0005646_abnormal_pituitary_gland	1.46123601
40	MP0000955_abnormal_spinal_cord	1.43837685
41	MP0002882_abnormal_neuron_morphology	1.43295494
42	MP0000920_abnormal_myelination	1.37612541
43	MP0003631_nervous_system_phenotype	1.36870510
44	MP0001502_abnormal_circadian_rhythm	1.35115078
45	MP0002822_catalepsy	1.34100218
46	MP0003690_abnormal_glial_cell	1.33552849
47	MP0005386_behavior/neurological_phenoty	1.32267424
48	MP0004924_abnormal_behavior	1.32267424
49	MP0002184_abnormal_innervation	1.27850116
50	MP0004742_abnormal_vestibular_system	1.21140076
51	MP0002152_abnormal_brain_morphology	1.14000452
52	MP0005623_abnormal_meninges_morphology	1.09550399
53	MP0003632_abnormal_nervous_system	1.05228927
54	MP0003634_abnormal_glial_cell	1.03796191
55	MP0002229_neurodegeneration	1.00775057
56	MP0001963_abnormal_hearing_physiology	0.99852573
57	MP0000604_amyloidosis	0.96063283
58	MP0002638_abnormal_pupillary_reflex	0.92574663
59	MP0003121_genomic_imprinting	0.88095847
60	MP0001188_hyperpigmentation	0.87264793
61	MP0001529_abnormal_vocalization	0.85926808
62	MP0001485_abnormal_pinna_reflex	0.84942077
63	MP0000566_synostosis	0.84109499
64	MP0001346_abnormal_lacrimal_gland	0.81732783
65	MP0002909_abnormal_adrenal_gland	0.81361878
66	MP0005551_abnormal_eye_electrophysiolog	0.80189573
67	MP0008874_decreased_physiological_sensi	0.80107698
68	MP0008877_abnormal_DNA_methylation	0.77955095
69	MP0002069_abnormal_eating/drinking_beha	0.75798442
70	MP0002752_abnormal_somatic_nervous	0.74952944
71	MP0001299_abnormal_eye_distance/	0.72749738
72	MP0003938_abnormal_ear_development	0.70654058
73	MP0003075_altered_response_to	0.68731014
74	MP0003283_abnormal_digestive_organ	0.67967830
75	MP0000751_myopathy	0.67768424
76	MP0000639_abnormal_adrenal_gland	0.67527452
77	MP0001986_abnormal_taste_sensitivity	0.67300847
78	MP0004142_abnormal_muscle_tone	0.64338185
79	MP0000579_abnormal_nail_morphology	0.63429530
80	MP0010386_abnormal_urinary_bladder	0.63392381
81	MP0003861_abnormal_nervous_system	0.63240109
82	MP0004085_abnormal_heartbeat	0.61879100
83	MP0000026_abnormal_inner_ear	0.61357953
84	MP0002090_abnormal_vision	0.60678793
85	MP0010769_abnormal_survival	0.59855324
86	MP0005499_abnormal_olfactory_system	0.58674792
87	MP0005394_taste/olfaction_phenotype	0.58674792
88	MP0003137_abnormal_impulse_conducting	0.57906999
89	MP0005535_abnormal_body_temperature	0.57544825
90	MP0005167_abnormal_blood-brain_barrier	0.57011138
91	MP0010768_mortality/aging	0.56759759
92	MP0002249_abnormal_larynx_morphology	0.56513442
93	MP0010770_preweaning_lethality	0.55760926
94	MP0002082_postnatal_lethality	0.55760926
95	MP0000631_abnormal_neuroendocrine_gland	0.54718008
96	MP0008872_abnormal_physiological_respon	0.54152013
97	MP0004130_abnormal_muscle_cell	0.53610139
98	MP0005187_abnormal_penis_morphology	0.52662181
99	MP0001943_abnormal_respiration	0.51313381
100	MP0003956_abnormal_body_size	0.48942523

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Myokymia (HP:0002411)	8.60119425
2	Focal motor seizures (HP:0011153)	7.14914366
3	Focal seizures (HP:0007359)	6.14841264
4	Action tremor (HP:0002345)	5.35965279
5	Febrile seizures (HP:0002373)	5.20679376
6	Epileptic encephalopathy (HP:0200134)	5.16448120
7	Atonic seizures (HP:0010819)	5.07310151
8	Limb dystonia (HP:0002451)	4.98535593
9	Supranuclear gaze palsy (HP:0000605)	4.82864956
10	Diplopia (HP:0000651)	4.29042792
11	Abnormality of binocular vision (HP:0011514)	4.29042792
12	Ankle clonus (HP:0011448)	4.20236980
13	Generalized tonic-clonic seizures (HP:0002069)	4.04315048
14	Neurofibrillary tangles (HP:0002185)	3.95845240
15	Visual hallucinations (HP:0002367)	3.83480546
16	Postural instability (HP:0002172)	3.83103373
17	Abnormal eating behavior (HP:0100738)	3.75946105
18	Torticollis (HP:0000473)	3.60382255
19	Progressive cerebellar ataxia (HP:0002073)	3.58727074
20	Spastic gait (HP:0002064)	3.49047152
21	Absence seizures (HP:0002121)	3.47166474
22	Urinary bladder sphincter dysfunction (HP:0002839)	3.36099420
23	Dialeptic seizures (HP:0011146)	3.31725340
24	Papilledema (HP:0001085)	3.31144055
25	Urinary urgency (HP:0000012)	3.30210512
26	Dysmetria (HP:0001310)	3.26417910
27	Cerebral inclusion bodies (HP:0100314)	3.25667361
28	Impaired vibration sensation in the lower limbs (HP:0002166)	3.22798371
29	Mutism (HP:0002300)	3.17574441
30	Annular pancreas (HP:0001734)	3.15259070
31	Depression (HP:0000716)	3.14274383
32	Bradykinesia (HP:0002067)	3.11535647
33	Truncal ataxia (HP:0002078)	3.05400726
34	Focal dystonia (HP:0004373)	3.04747439
35	Cerebral hypomyelination (HP:0006808)	3.03744549
36	Anxiety (HP:0000739)	2.95848894
37	Obstructive sleep apnea (HP:0002870)	2.90165970
38	Epileptiform EEG discharges (HP:0011182)	2.87991486
39	Akinesia (HP:0002304)	2.84437730
40	Craniofacial dystonia (HP:0012179)	2.80995217
41	Poor eye contact (HP:0000817)	2.80658597
42	Intention tremor (HP:0002080)	2.78756798
43	Tetraplegia (HP:0002445)	2.77173765
44	Delusions (HP:0000746)	2.69605110
45	Status epilepticus (HP:0002133)	2.69226936
46	Hemiplegia (HP:0002301)	2.65078652
47	Abnormality of the corticospinal tract (HP:0002492)	2.56640444
48	Sleep apnea (HP:0010535)	2.52159094
49	EEG with generalized epileptiform discharges (HP:0011198)	2.52080560
50	Abnormal social behavior (HP:0012433)	2.51622769
51	Impaired social interactions (HP:0000735)	2.51622769
52	Rigidity (HP:0002063)	2.51573010
53	Polyphagia (HP:0002591)	2.51316401
54	Neuronal loss in central nervous system (HP:0002529)	2.46717984
55	Aplasia involving bones of the extremities (HP:0009825)	2.46098518
56	Aplasia involving bones of the upper limbs (HP:0009823)	2.46098518
57	Aplasia of the phalanges of the hand (HP:0009802)	2.46098518
58	Dysdiadochokinesis (HP:0002075)	2.45371515
59	Apathy (HP:0000741)	2.43481268
60	Amblyopia (HP:0000646)	2.40118020
61	Lower limb muscle weakness (HP:0007340)	2.39081501
62	Ventricular fibrillation (HP:0001663)	2.38388047
63	Hypsarrhythmia (HP:0002521)	2.34168539
64	Clonus (HP:0002169)	2.33915271
65	Abnormality of the lower motor neuron (HP:0002366)	2.20472926
66	Insomnia (HP:0100785)	2.17961274
67	Diminished motivation (HP:0000745)	2.17942824
68	Stereotypic behavior (HP:0000733)	2.17861470
69	Spastic tetraparesis (HP:0001285)	2.17800982
70	Hemiparesis (HP:0001269)	2.15934401
71	Morphological abnormality of the pyramidal tract (HP:0002062)	2.13529158
72	Peripheral hypomyelination (HP:0007182)	2.11691892
73	Bronchomalacia (HP:0002780)	2.10672776
74	Drooling (HP:0002307)	2.08475117
75	Impaired vibratory sensation (HP:0002495)	2.06868148
76	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	2.02194729
77	Impaired smooth pursuit (HP:0007772)	2.01643312
78	Incomplete penetrance (HP:0003829)	2.01445565
79	Turricephaly (HP:0000262)	1.99931207
80	Broad-based gait (HP:0002136)	1.99127656
81	CNS hypomyelination (HP:0003429)	1.97466575
82	Megalencephaly (HP:0001355)	1.95753488
83	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.95748507
84	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.95748507
85	Resting tremor (HP:0002322)	1.92905469
86	Choreoathetosis (HP:0001266)	1.90125558
87	Excessive salivation (HP:0003781)	1.88829023
88	Split foot (HP:0001839)	1.87529196
89	Fetal akinesia sequence (HP:0001989)	1.87428019
90	Rapidly progressive (HP:0003678)	1.87372856
91	Lower limb amyotrophy (HP:0007210)	1.82336116
92	Bundle branch block (HP:0011710)	1.80205113
93	Prolonged QT interval (HP:0001657)	1.76102674
94	Lower limb asymmetry (HP:0100559)	1.75711906
95	Increased circulating renin level (HP:0000848)	1.75564754
96	Syncope (HP:0001279)	1.73832199
97	Diminished movement (HP:0002374)	1.73457221
98	Unsteady gait (HP:0002317)	1.72973076
99	Abnormality of ocular smooth pursuit (HP:0000617)	1.72280595
100	Abnormal EKG (HP:0003115)	1.71482831

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EPHA4	5.89825610
2	PAK6	3.80236644
3	NTRK3	3.72849003
4	MARK1	3.52807768
5	DAPK2	3.46551238
6	MAP3K9	3.05565577
7	PINK1	2.84375545
8	NTRK2	2.62977919
9	PRKD3	2.54309759
10	LATS2	2.33092796
11	MINK1	2.32759485
12	UHMK1	2.23198141
13	NTRK1	2.15387755
14	CAMKK1	2.13975940
15	CASK	2.07732084
16	ARAF	1.83601487
17	GRK5	1.70128977
18	CDK5	1.67567422
19	PLK2	1.57498087
20	CDK19	1.56738949
21	CAMK1	1.51614018
22	SGK494	1.37242478
23	SGK223	1.37242478
24	DAPK1	1.32773543
25	KSR2	1.32714210
26	PHKG1	1.31368993
27	PHKG2	1.31368993
28	PRKCG	1.30088722
29	TYRO3	1.30064971
30	CAMK2B	1.26763226
31	CDK15	1.25976610
32	MAPK13	1.23327433
33	CDK18	1.20846053
34	CDK14	1.20740708
35	CDK11A	1.15303272
36	PRPF4B	1.12156563
37	RIPK1	1.06565148
38	SIK2	1.00829384
39	MAPK12	0.99670222
40	PRKCH	0.99482831
41	PAK3	0.98398846
42	CAMK2A	0.95600042
43	MARK2	0.93431256
44	STK11	0.92976859
45	RIPK4	0.92942223
46	DYRK1A	0.91311057
47	MAPKAPK5	0.90974302
48	PNCK	0.89781219
49	BRSK1	0.88459106
50	PKN1	0.88124564
51	SGK2	0.85918405
52	ALK	0.82082318
53	STK38	0.81583161
54	CAMK2G	0.80669716
55	OXSR1	0.77501017
56	MAP3K13	0.76079211
57	CAMKK2	0.73761820
58	FGFR2	0.73169605
59	DAPK3	0.72979113
60	NEK6	0.72780222
61	MAP2K7	0.72322206
62	SGK3	0.68638320
63	TNIK	0.67075229
64	CSNK1G2	0.66343769
65	SGK1	0.66236965
66	CAMK4	0.64852700
67	MAP3K11	0.62608468
68	PDK1	0.59103984
69	MAP3K4	0.58873034
70	MAP3K12	0.58157050
71	KSR1	0.57353797
72	PRKG2	0.56834701
73	MAPK10	0.55693173
74	CAMK1G	0.54908732
75	RPS6KA3	0.53331422
76	MAP2K4	0.52949013
77	PDPK1	0.52781311
78	BRAF	0.51349403
79	CAMK2D	0.50938621
80	PRKCZ	0.47219295
81	ICK	0.44797785
82	RET	0.44118960
83	ROCK2	0.42449164
84	DYRK2	0.42114781
85	MAP3K1	0.38553048
86	RAF1	0.36872545
87	ROCK1	0.35784657
88	CAMK1D	0.34930141
89	LIMK1	0.34658302
90	MOS	0.31888729
91	CSNK1E	0.28972162
92	PRKCA	0.28585968
93	FES	0.28449861
94	WNK1	0.27912746
95	FYN	0.27468093
96	MAP3K2	0.27431754
97	LMTK2	0.26696075
98	CSNK1G3	0.25530995
99	IRAK2	0.24603948
100	RPS6KB1	0.23991794

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	4.09040153
2	Synaptic vesicle cycle_Homo sapiens_hsa04721	4.01482303
3	Amphetamine addiction_Homo sapiens_hsa05031	2.94680580
4	Long-term potentiation_Homo sapiens_hsa04720	2.80283628
5	Circadian entrainment_Homo sapiens_hsa04713	2.65402333
6	GABAergic synapse_Homo sapiens_hsa04727	2.63719567
7	Glutamatergic synapse_Homo sapiens_hsa04724	2.47118344
8	Morphine addiction_Homo sapiens_hsa05032	2.46288444
9	Insulin secretion_Homo sapiens_hsa04911	2.43254047
10	Cocaine addiction_Homo sapiens_hsa05030	2.34065323
11	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	2.32558569
12	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	2.32018493
13	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	2.24926712
14	Dopaminergic synapse_Homo sapiens_hsa04728	2.19561898
15	Gastric acid secretion_Homo sapiens_hsa04971	2.10762469
16	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.99868472
17	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	1.86414582
18	Cholinergic synapse_Homo sapiens_hsa04725	1.84179183
19	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.83780103
20	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.79169510
21	Salivary secretion_Homo sapiens_hsa04970	1.69276737
22	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.64637953
23	Calcium signaling pathway_Homo sapiens_hsa04020	1.49922409
24	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.48976606
25	cAMP signaling pathway_Homo sapiens_hsa04024	1.45633670
26	Renin secretion_Homo sapiens_hsa04924	1.40749076
27	Gap junction_Homo sapiens_hsa04540	1.36787705
28	Olfactory transduction_Homo sapiens_hsa04740	1.35851348
29	Taste transduction_Homo sapiens_hsa04742	1.32126371
30	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	1.29482946
31	Cardiac muscle contraction_Homo sapiens_hsa04260	1.24171584
32	GnRH signaling pathway_Homo sapiens_hsa04912	1.20998188
33	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.20887568
34	Melanogenesis_Homo sapiens_hsa04916	1.16269696
35	Estrogen signaling pathway_Homo sapiens_hsa04915	1.15732706
36	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	1.10107439
37	Long-term depression_Homo sapiens_hsa04730	1.09866188
38	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	1.09215837
39	Glioma_Homo sapiens_hsa05214	1.08947289
40	Collecting duct acid secretion_Homo sapiens_hsa04966	1.05580222
41	Serotonergic synapse_Homo sapiens_hsa04726	1.04607357
42	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	1.00315611
43	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.98898666
44	Oocyte meiosis_Homo sapiens_hsa04114	0.95828670
45	Bile secretion_Homo sapiens_hsa04976	0.91589265
46	Axon guidance_Homo sapiens_hsa04360	0.90718676
47	Pancreatic secretion_Homo sapiens_hsa04972	0.88476717
48	ErbB signaling pathway_Homo sapiens_hsa04012	0.83932156
49	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.83099978
50	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.80576540
51	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.77755858
52	Prion diseases_Homo sapiens_hsa05020	0.75042569
53	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.72912862
54	Vibrio cholerae infection_Homo sapiens_hsa05110	0.72620408
55	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.68757329
56	Glucagon signaling pathway_Homo sapiens_hsa04922	0.67910759
57	Type II diabetes mellitus_Homo sapiens_hsa04930	0.67313176
58	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.67261505
59	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.65159946
60	Phototransduction_Homo sapiens_hsa04744	0.64942880
61	Arginine biosynthesis_Homo sapiens_hsa00220	0.62972191
62	Alcoholism_Homo sapiens_hsa05034	0.62107099
63	Rap1 signaling pathway_Homo sapiens_hsa04015	0.61556475
64	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.61111317
65	MAPK signaling pathway_Homo sapiens_hsa04010	0.60260274
66	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.59217943
67	Arginine and proline metabolism_Homo sapiens_hsa00330	0.57523109
68	Ras signaling pathway_Homo sapiens_hsa04014	0.55784458
69	Wnt signaling pathway_Homo sapiens_hsa04310	0.55519300
70	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.55149838
71	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.53796856
72	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.52914663
73	VEGF signaling pathway_Homo sapiens_hsa04370	0.52715816
74	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.52686047
75	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.52233043
76	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.52158398
77	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.47387989
78	Alzheimers disease_Homo sapiens_hsa05010	0.46259306
79	Tight junction_Homo sapiens_hsa04530	0.43125940
80	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.42977788
81	Hippo signaling pathway_Homo sapiens_hsa04390	0.42587109
82	Choline metabolism in cancer_Homo sapiens_hsa05231	0.40950139
83	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.39309618
84	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.36385794
85	Butanoate metabolism_Homo sapiens_hsa00650	0.35620681
86	Endocytosis_Homo sapiens_hsa04144	0.35347674
87	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.35273705
88	Circadian rhythm_Homo sapiens_hsa04710	0.34691437
89	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.33889702
90	beta-Alanine metabolism_Homo sapiens_hsa00410	0.33735058
91	Histidine metabolism_Homo sapiens_hsa00340	0.33275493
92	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.32342149
93	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.32069693
94	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.30930800
95	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.30596045
96	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.29546327
97	Insulin signaling pathway_Homo sapiens_hsa04910	0.29241775
98	Endometrial cancer_Homo sapiens_hsa05213	0.27920587
99	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.27260011
100	AMPK signaling pathway_Homo sapiens_hsa04152	0.25680948

SMIM10L2B

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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