ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	8.03004432
2	energy coupled proton transport, down electrochemical gradient (GO:0015985)	7.60356810
3	ATP synthesis coupled proton transport (GO:0015986)	7.60356810
4	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	6.79438336
5	respiratory electron transport chain (GO:0022904)	6.41857094
6	electron transport chain (GO:0022900)	6.28183034
7	chaperone-mediated protein transport (GO:0072321)	5.66186927
8	oxidative phosphorylation (GO:0006119)	5.13503597
9	mitochondrial respiratory chain complex I assembly (GO:0032981)	5.12370987
10	NADH dehydrogenase complex assembly (GO:0010257)	5.12370987
11	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	5.12370987
12	protein complex biogenesis (GO:0070271)	5.06569970
13	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.94784631
14	proteasome assembly (GO:0043248)	4.92697615
15	protein neddylation (GO:0045116)	4.87627883
16	mitochondrial respiratory chain complex assembly (GO:0033108)	4.69824701
17	cullin deneddylation (GO:0010388)	4.35392173
18	ATP biosynthetic process (GO:0006754)	4.33712801
19	hydrogen ion transmembrane transport (GO:1902600)	4.24401744
20	respiratory chain complex IV assembly (GO:0008535)	4.18635028
21	protein targeting to mitochondrion (GO:0006626)	4.18506506
22	establishment of protein localization to mitochondrion (GO:0072655)	4.14057798
23	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	4.12801667
24	protein deneddylation (GO:0000338)	4.11983898
25	regulation of cellular amino acid metabolic process (GO:0006521)	4.09543643
26	purine nucleoside triphosphate biosynthetic process (GO:0009145)	4.08688525
27	inner mitochondrial membrane organization (GO:0007007)	4.08455231
28	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.93485225
29	dopamine transport (GO:0015872)	3.91404811
30	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.89297960
31	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.89297960
32	protein localization to mitochondrion (GO:0070585)	3.88541261
33	DNA deamination (GO:0045006)	3.88168601
34	platelet dense granule organization (GO:0060155)	3.86916237
35	cytochrome complex assembly (GO:0017004)	3.85439665
36	pseudouridine synthesis (GO:0001522)	3.83669260
37	rRNA modification (GO:0000154)	3.80583674
38	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.75944051
39	regulation of mitochondrial translation (GO:0070129)	3.74263733
40	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.74258823
41	proton transport (GO:0015992)	3.72382597
42	ribosomal small subunit assembly (GO:0000028)	3.71034914
43	energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)	3.70400186
44	ATP hydrolysis coupled proton transport (GO:0015991)	3.70400186
45	regulation of cellular respiration (GO:0043457)	3.66883487
46	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.66179231
47	peptidyl-histidine modification (GO:0018202)	3.65777958
48	hydrogen transport (GO:0006818)	3.64116779
49	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	3.60732897
50	negative regulation of ligase activity (GO:0051352)	3.60732897
51	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	3.57169653
52	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	3.55141165
53	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	3.55141165
54	ribosomal small subunit biogenesis (GO:0042274)	3.55068150
55	termination of RNA polymerase III transcription (GO:0006386)	3.53462918
56	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.53462918
57	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.51913335
58	aerobic respiration (GO:0009060)	3.49575234
59	viral transcription (GO:0019083)	3.49275654
60	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	3.48661354
61	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	3.48661354
62	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	3.48661354
63	GTP biosynthetic process (GO:0006183)	3.39612701
64	tricarboxylic acid cycle (GO:0006099)	3.38849422
65	nucleoside triphosphate biosynthetic process (GO:0009142)	3.38268017
66	sequestering of actin monomers (GO:0042989)	3.37694591
67	signal transduction involved in DNA integrity checkpoint (GO:0072401)	3.35493566
68	signal transduction involved in DNA damage checkpoint (GO:0072422)	3.35493566
69	guanosine-containing compound biosynthetic process (GO:1901070)	3.35352605
70	translational termination (GO:0006415)	3.35305390
71	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.34400696
72	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	3.33858540
73	positive regulation of mitochondrial fission (GO:0090141)	3.32541070
74	mannosylation (GO:0097502)	3.31528629
75	maturation of 5.8S rRNA (GO:0000460)	3.30792714
76	NADH metabolic process (GO:0006734)	3.30648472
77	antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	3.29309475
78	protein-cofactor linkage (GO:0018065)	3.28770238
79	signal transduction involved in cell cycle checkpoint (GO:0072395)	3.28580674
80	mitochondrial transport (GO:0006839)	3.28502552
81	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.27169473
82	regulation of cellular amine metabolic process (GO:0033238)	3.25075136
83	quinone biosynthetic process (GO:1901663)	3.24708001
84	ubiquinone biosynthetic process (GO:0006744)	3.24708001
85	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	3.23826255
86	rRNA methylation (GO:0031167)	3.23825334
87	base-excision repair, AP site formation (GO:0006285)	3.23518646
88	purine nucleoside monophosphate biosynthetic process (GO:0009127)	3.22629196
89	purine ribonucleoside monophosphate biosynthetic process (GO:0009168)	3.22629196
90	mitochondrial fragmentation involved in apoptotic process (GO:0043653)	3.21711333
91	RNA capping (GO:0036260)	3.20946348
92	7-methylguanosine RNA capping (GO:0009452)	3.20946348
93	7-methylguanosine mRNA capping (GO:0006370)	3.20655582
94	regulation of oxidative phosphorylation (GO:0002082)	3.20097301
95	translational elongation (GO:0006414)	3.18466512
96	translation (GO:0006412)	3.12687338
97	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	3.12051226
98	kynurenine metabolic process (GO:0070189)	3.09473590
99	cotranslational protein targeting to membrane (GO:0006613)	3.03525004
100	nucleobase-containing small molecule interconversion (GO:0015949)	3.01780387
101	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.01026951
102	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.98776486
103	L-methionine biosynthetic process (GO:0071265)	2.97318272
104	amino acid salvage (GO:0043102)	2.97318272
105	L-methionine salvage (GO:0071267)	2.97318272
106	maturation of SSU-rRNA (GO:0030490)	2.97121396
107	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.96638624
108	iron-sulfur cluster assembly (GO:0016226)	2.96295096
109	metallo-sulfur cluster assembly (GO:0031163)	2.96295096
110	protein targeting to ER (GO:0045047)	2.96148450
111	ubiquinone metabolic process (GO:0006743)	2.92565250
112	tRNA processing (GO:0008033)	2.92490503
113	protein localization to endoplasmic reticulum (GO:0070972)	2.92197965
114	indole-containing compound catabolic process (GO:0042436)	2.88864773
115	indolalkylamine catabolic process (GO:0046218)	2.88864773
116	tryptophan catabolic process (GO:0006569)	2.88864773
117	signal peptide processing (GO:0006465)	2.88264369
118	preassembly of GPI anchor in ER membrane (GO:0016254)	2.84956786
119	positive regulation of ligase activity (GO:0051351)	2.77287628
120	negative regulation of mast cell activation (GO:0033004)	2.68840547
121	mitochondrial RNA metabolic process (GO:0000959)	2.68161203
122	deoxyribonucleotide catabolic process (GO:0009264)	2.65925591
123	purine nucleotide salvage (GO:0032261)	2.56538763
124	cellular ketone body metabolic process (GO:0046950)	2.56410967
125	dolichol-linked oligosaccharide biosynthetic process (GO:0006488)	2.52990133
126	tryptophan metabolic process (GO:0006568)	2.52936715
127	amine catabolic process (GO:0009310)	2.51690476
128	cellular biogenic amine catabolic process (GO:0042402)	2.51690476
129	negative regulation of inflammatory response to antigenic stimulus (GO:0002862)	2.51492415
130	methionine biosynthetic process (GO:0009086)	2.51435378
131	indolalkylamine metabolic process (GO:0006586)	2.49813941
132	DNA damage response, signal transduction by p53 class mediator (GO:0030330)	2.49597430
133	water-soluble vitamin biosynthetic process (GO:0042364)	2.49075973
134	positive regulation of prostaglandin secretion (GO:0032308)	2.48669316
135	C-terminal protein lipidation (GO:0006501)	2.47378295
136	deoxyribose phosphate catabolic process (GO:0046386)	2.46967750
137	tRNA metabolic process (GO:0006399)	2.46305108
138	organelle membrane fusion (GO:0090174)	2.45347212
139	positive regulation of cell cycle arrest (GO:0071158)	2.44407506
140	purine-containing compound salvage (GO:0043101)	2.43332396
141	tRNA modification (GO:0006400)	2.42198010

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	5.09770955
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.53715747
3	EST1_17652178_ChIP-ChIP_JURKAT_Human	4.36017985
4	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	4.34183577
5	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	4.13279197
6	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	4.09629333
7	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.95047122
8	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.81681790
9	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.73311490
10	CREB1_15753290_ChIP-ChIP_HEK293T_Human	3.56010743
11	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.51311035
12	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.39784731
13	THAP11_20581084_ChIP-Seq_MESCs_Mouse	3.04298320
14	MYC_18358816_ChIP-ChIP_MESCs_Mouse	3.00937197
15	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.99737571
16	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	2.87235134
17	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.80154830
18	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.73298567
19	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.70797992
20	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.68532756
21	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.61859880
22	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.61282895
23	DCP1A_22483619_ChIP-Seq_HELA_Human	2.51381197
24	YY1_21170310_ChIP-Seq_MESCs_Mouse	2.47161187
25	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.41609347
26	E2F1_18555785_ChIP-Seq_MESCs_Mouse	2.38601302
27	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.38323479
28	VDR_23849224_ChIP-Seq_CD4+_Human	2.32728861
29	XRN2_22483619_ChIP-Seq_HELA_Human	2.29711122
30	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.25423973
31	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.17214712
32	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	2.14907670
33	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	2.11977490
34	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.11322424
35	FOXP3_21729870_ChIP-Seq_TREG_Human	2.02101205
36	ZNF274_21170338_ChIP-Seq_K562_Hela	1.97675265
37	GABP_19822575_ChIP-Seq_HepG2_Human	1.93783370
38	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.91117407
39	TTF2_22483619_ChIP-Seq_HELA_Human	1.88878978
40	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.82219058
41	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.74770235
42	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.74226629
43	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.67045124
44	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.56335068
45	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.55565034
46	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.51121108
47	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.49480945
48	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.48281017
49	ELK1_19687146_ChIP-ChIP_HELA_Human	1.47591209
50	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.42458652
51	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.41607796
52	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.37717905
53	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.34612115
54	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.34606278
55	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	1.33365782
56	TAF15_26573619_Chip-Seq_HEK293_Human	1.31868625
57	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.31391931
58	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.29348554
59	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.28348484
60	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.28317846
61	KDM5A_27292631_Chip-Seq_BREAST_Human	1.26249312
62	VDR_22108803_ChIP-Seq_LS180_Human	1.26016514
63	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.18028468
64	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.17293071
65	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.17271720
66	TFEB_21752829_ChIP-Seq_HELA_Human	1.15266985
67	GATA3_26560356_Chip-Seq_TH2_Human	1.15083403
68	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.14951941
69	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.14048988
70	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.11482517
71	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.11480482
72	MYC_18940864_ChIP-ChIP_HL60_Human	1.11202489
73	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.10960293
74	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.10394528
75	SPI1_23547873_ChIP-Seq_NB4_Human	1.09446839
76	TP53_22573176_ChIP-Seq_HFKS_Human	1.09262232
77	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.09126708
78	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.07683856
79	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.04575982
80	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.01328824
81	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.01260615
82	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.00104315
83	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	0.99414954
84	IRF1_19129219_ChIP-ChIP_H3396_Human	0.99066416
85	STAT4_19710469_ChIP-ChIP_TH1__Mouse	0.98929757
86	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.96915861
87	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.95660719
88	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	0.95587565
89	NANOG_18555785_ChIP-Seq_MESCs_Mouse	0.93531026
90	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	0.91964467
91	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.91485804
92	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	0.91402032
93	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.90418145
94	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.90245021
95	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.89000504
96	AR_20517297_ChIP-Seq_VCAP_Human	0.88658439
97	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	0.88616205
98	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.85848872
99	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.85848872
100	MYCN_18555785_ChIP-Seq_MESCs_Mouse	0.85537264
101	OCT4_18692474_ChIP-Seq_MEFs_Mouse	0.85020041
102	MYB_26560356_Chip-Seq_TH2_Human	0.84947890
103	TBX5_21415370_ChIP-Seq_HL-1_Mouse	0.84920457
104	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.84715515
105	NANOG_20526341_ChIP-Seq_ESCs_Human	0.84069936
106	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.83813877
107	STAT3_1855785_ChIP-Seq_MESCs_Mouse	0.83738770
108	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.82813592
109	TET1_21451524_ChIP-Seq_MESCs_Mouse	0.82763951
110	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.82602033
111	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	0.82554560
112	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	0.82431996
113	EZH2_22144423_ChIP-Seq_EOC_Human	0.81963499
114	TAF2_19829295_ChIP-Seq_ESCs_Human	0.80745294
115	STAT1_20625510_ChIP-Seq_HELA_Human	0.80682396
116	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	0.80323760
117	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.80015313
118	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	0.79881315
119	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	0.79315010
120	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.79296330
121	CIITA_25753668_ChIP-Seq_RAJI_Human	0.78779980
122	NCOR_22424771_ChIP-Seq_293T_Human	0.77213442
123	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	0.77030689
124	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.76733445
125	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.75258621
126	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.74834358
127	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.74294508
128	SOX2_18692474_ChIP-Seq_MEFs_Mouse	0.73420650
129	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.73299257
130	* CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.72354920
131	SOX17_20123909_ChIP-Seq_XEN_Mouse	0.71285687
132	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	0.70549375
133	FOXP1_21924763_ChIP-Seq_HESCs_Human	0.69413270
134	BCL6_27268052_Chip-Seq_Bcells_Human	0.68289545
135	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	0.68090619
136	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.67495667
137	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	0.66614318

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003880_abnormal_central_pattern	4.15320366
2	MP0001529_abnormal_vocalization	3.51379134
3	MP0001905_abnormal_dopamine_level	3.07495604
4	MP0006036_abnormal_mitochondrial_physio	3.05040525
5	MP0003646_muscle_fatigue	3.03653190
6	MP0002822_catalepsy	2.99336597
7	MP0002837_dystrophic_cardiac_calcinosis	2.97680567
8	MP0002736_abnormal_nociception_after	2.91643830
9	MP0003195_calcinosis	2.82454918
10	MP0001968_abnormal_touch/_nociception	2.74570542
11	MP0002735_abnormal_chemical_nociception	2.57456245
12	MP0006035_abnormal_mitochondrial_morpho	2.55864873
13	MP0006276_abnormal_autonomic_nervous	2.48682947
14	MP0000749_muscle_degeneration	2.43939272
15	MP0000015_abnormal_ear_pigmentation	2.35179897
16	MP0009379_abnormal_foot_pigmentation	2.34265722
17	MP0004142_abnormal_muscle_tone	2.27308380
18	MP0005671_abnormal_response_to	2.27154491
19	MP0003186_abnormal_redox_activity	2.26801915
20	MP0003806_abnormal_nucleotide_metabolis	2.21519816
21	MP0009745_abnormal_behavioral_response	2.17532925
22	MP0002148_abnormal_hypersensitivity_rea	2.12840263
23	MP0009785_altered_susceptibility_to	2.11655352
24	MP0009046_muscle_twitch	2.11225425
25	MP0002064_seizures	2.09115684
26	MP0004859_abnormal_synaptic_plasticity	2.02610242
27	MP0002272_abnormal_nervous_system	2.01174314
28	MP0002138_abnormal_hepatobiliary_system	1.97458689
29	MP0008058_abnormal_DNA_repair	1.90700377
30	MP0001835_abnormal_antigen_presentation	1.90494793
31	MP0005410_abnormal_fertilization	1.89590444
32	MP0003635_abnormal_synaptic_transmissio	1.83581572
33	MP0002139_abnormal_hepatobiliary_system	1.83063671
34	MP0009764_decreased_sensitivity_to	1.81339693
35	MP0004036_abnormal_muscle_relaxation	1.79901743
36	MP0002733_abnormal_thermal_nociception	1.78423998
37	MP0001984_abnormal_olfaction	1.77648237
38	MP0001970_abnormal_pain_threshold	1.77443574
39	MP0000751_myopathy	1.77299143
40	MP0004147_increased_porphyrin_level	1.74471263
41	MP0005174_abnormal_tail_pigmentation	1.71351882
42	MP0004084_abnormal_cardiac_muscle	1.68991980
43	MP0005075_abnormal_melanosome_morpholog	1.67466871
44	MP0002332_abnormal_exercise_endurance	1.66930967
45	MP0002734_abnormal_mechanical_nocicepti	1.64717271
46	MP0004215_abnormal_myocardial_fiber	1.58567454
47	MP0004270_analgesia	1.57819825
48	MP0008872_abnormal_physiological_respon	1.54026494
49	MP0005058_abnormal_lysosome_morphology	1.46056817
50	MP0009840_abnormal_foam_cell	1.45995131
51	MP0001790_abnormal_immune_system	1.44438340
52	MP0005387_immune_system_phenotype	1.44438340
53	MP0002254_reproductive_system_inflammat	1.44329448
54	MP0002572_abnormal_emotion/affect_behav	1.43886427
55	MP0001440_abnormal_grooming_behavior	1.42309733
56	MP0003724_increased_susceptibility_to	1.41432829
57	MP0005000_abnormal_immune_tolerance	1.40800555
58	MP0006072_abnormal_retinal_apoptosis	1.39490435
59	MP0003221_abnormal_cardiomyocyte_apopto	1.37091465
60	MP0005330_cardiomyopathy	1.36042602
61	MP0002063_abnormal_learning/memory/cond	1.35817939
62	MP0003693_abnormal_embryo_hatching	1.34785852
63	MP0006082_CNS_inflammation	1.34483846
64	MP0005451_abnormal_body_composition	1.34482436
65	MP0000685_abnormal_immune_system	1.34472096
66	MP0002723_abnormal_immune_serum	1.32695860
67	MP0004924_abnormal_behavior	1.32424226
68	MP0005386_behavior/neurological_phenoty	1.32424226
69	MP0001501_abnormal_sleep_pattern	1.31653030
70	MP0001986_abnormal_taste_sensitivity	1.30636581
71	MP0005332_abnormal_amino_acid	1.30463597
72	MP0002452_abnormal_antigen_presenting	1.29371453
73	MP0001853_heart_inflammation	1.29251647
74	MP0004145_abnormal_muscle_electrophysio	1.26277908
75	MP0005025_abnormal_response_to	1.25013739
76	MP0002067_abnormal_sensory_capabilities	1.23819802
77	MP0001800_abnormal_humoral_immune	1.23787761
78	MP0008260_abnormal_autophagy	1.23029183
79	MP0005266_abnormal_metabolism	1.22067785
80	MP0005409_darkened_coat_color	1.21668435
81	MP0002972_abnormal_cardiac_muscle	1.21224946
82	MP0005379_endocrine/exocrine_gland_phen	1.20556656
83	MP0008007_abnormal_cellular_replicative	1.20072847
84	MP0005551_abnormal_eye_electrophysiolog	1.16841456
85	MP0002102_abnormal_ear_morphology	1.16166352
86	MP0004484_altered_response_of	1.15992379
87	MP0002693_abnormal_pancreas_physiology	1.15593944
88	MP0008469_abnormal_protein_level	1.15538491
89	MP0000358_abnormal_cell_content/	1.15409921
90	MP0002419_abnormal_innate_immunity	1.14466035
91	MP0005253_abnormal_eye_physiology	1.14160165
92	MP0005083_abnormal_biliary_tract	1.12738796
93	MP0001845_abnormal_inflammatory_respons	1.12594489
94	MP0002420_abnormal_adaptive_immunity	1.11734107
95	MP0001819_abnormal_immune_cell	1.10811778
96	MP0003122_maternal_imprinting	1.10599825
97	MP0008932_abnormal_embryonic_tissue	1.09502692
98	MP0004957_abnormal_blastocyst_morpholog	1.09355007
99	MP0005670_abnormal_white_adipose	1.08076011
100	MP0000371_diluted_coat_color	1.07470960
101	MP0010094_abnormal_chromosome_stability	1.07313986
102	MP0002184_abnormal_innervation	1.07259392
103	MP0000343_altered_response_to	1.06510517
104	MP0005423_abnormal_somatic_nervous	1.05029641
105	MP0000747_muscle_weakness	1.04779881
106	MP0002876_abnormal_thyroid_physiology	1.04333531
107	MP0009697_abnormal_copulation	1.04210958
108	MP0002095_abnormal_skin_pigmentation	1.03193535
109	MP0005084_abnormal_gallbladder_morpholo	1.02568908
110	MP0008875_abnormal_xenobiotic_pharmacok	1.01861390
111	MP0005408_hypopigmentation	1.00221329
112	MP0005464_abnormal_platelet_physiology	0.99667935
113	MP0005636_abnormal_mineral_homeostasis	0.98791342
114	MP0001486_abnormal_startle_reflex	0.97924024
115	MP0003136_yellow_coat_color	0.97655676
116	MP0005365_abnormal_bile_salt	0.94723506
117	MP0005319_abnormal_enzyme/_coenzyme	0.94250725
118	MP0000689_abnormal_spleen_morphology	0.94006680
119	MP0005310_abnormal_salivary_gland	0.93867083
120	MP0003436_decreased_susceptibility_to	0.93783238
121	MP0005620_abnormal_muscle_contractility	0.93213464
122	MP0004043_abnormal_pH_regulation	0.92971429
123	MP0001545_abnormal_hematopoietic_system	0.92834100
124	MP0005397_hematopoietic_system_phenotyp	0.92834100
125	MP0003950_abnormal_plasma_membrane	0.92793771
126	MP0005584_abnormal_enzyme/coenzyme_acti	0.92722223
127	MP0002638_abnormal_pupillary_reflex	0.91545548
128	MP0001764_abnormal_homeostasis	0.91349693
129	MP0001188_hyperpigmentation	0.91164007
130	MP0010386_abnormal_urinary_bladder	0.90526848
131	MP0002269_muscular_atrophy	0.90049665
132	MP0001919_abnormal_reproductive_system	0.89943599
133	MP0005389_reproductive_system_phenotype	0.88773194
134	MP0002751_abnormal_autonomic_nervous	0.87037697
135	MP0002066_abnormal_motor_capabilities/c	0.86379333
136	MP0003303_peritoneal_inflammation	0.85629536
137	MP0005645_abnormal_hypothalamus_physiol	0.85340148
138	MP0003252_abnormal_bile_duct	0.85286464
139	MP0003137_abnormal_impulse_conducting	0.85119793
140	MP0001544_abnormal_cardiovascular_syste	0.83961514
141	MP0005385_cardiovascular_system_phenoty	0.83961514
142	MP0003172_abnormal_lysosome_physiology	0.83774283
143	MP0002277_abnormal_respiratory_mucosa	0.83233591
144	MP0004811_abnormal_neuron_physiology	0.83033620
145	MP0000372_irregular_coat_pigmentation	0.81748472
146	MP0002160_abnormal_reproductive_system	0.81435031
147	MP0000716_abnormal_immune_system	0.80702999
148	MP0000569_abnormal_digit_pigmentation	0.80174847
149	MP0008874_decreased_physiological_sensi	0.79931680
150	MP0002163_abnormal_gland_morphology	0.79196613
151	MP0005376_homeostasis/metabolism_phenot	0.77239242
152	MP0005165_increased_susceptibility_to	0.77146055
153	MP0002106_abnormal_muscle_physiology	0.75942755
154	MP0009333_abnormal_splenocyte_physiolog	0.75276229
155	MP0001727_abnormal_embryo_implantation	0.74986415
156	MP0004085_abnormal_heartbeat	0.74151204
157	MP0005535_abnormal_body_temperature	0.74031690
158	MP0003786_premature_aging	0.73131782
159	MP0004133_heterotaxia	0.72732025
160	MP0003718_maternal_effect	0.70253719
161	MP0008775_abnormal_heart_ventricle	0.67884394
162	MP0006138_congestive_heart_failure	0.67736423
163	MP0003123_paternal_imprinting	0.67500656
164	MP0008877_abnormal_DNA_methylation	0.66774560
165	MP0003656_abnormal_erythrocyte_physiolo	0.66729261
166	MP0003879_abnormal_hair_cell	0.66496763
167	MP0008569_lethality_at_weaning	0.64725100
168	MP0003329_amyloid_beta_deposits	0.64206280
169	MP0002229_neurodegeneration	0.62874802

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	7.19547765
2	Abnormal mitochondria in muscle tissue (HP:0008316)	6.72440694
3	Mitochondrial inheritance (HP:0001427)	6.31091954
4	Acute encephalopathy (HP:0006846)	6.00866213
5	Progressive macrocephaly (HP:0004481)	5.93009523
6	Hepatocellular necrosis (HP:0001404)	5.88057097
7	Increased CSF lactate (HP:0002490)	5.57899211
8	Hepatic necrosis (HP:0002605)	5.17256681
9	Increased hepatocellular lipid droplets (HP:0006565)	4.46086120
10	Increased serum pyruvate (HP:0003542)	4.44236186
11	Abnormality of glycolysis (HP:0004366)	4.44236186
12	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	4.38135866
13	Cerebral edema (HP:0002181)	4.25566386
14	Neuroendocrine neoplasm (HP:0100634)	4.21854283
15	Lipid accumulation in hepatocytes (HP:0006561)	4.09481853
16	Exercise intolerance (HP:0003546)	4.03901421
17	Respiratory failure (HP:0002878)	4.01162459
18	Lactic acidosis (HP:0003128)	3.97830186
19	Renal Fanconi syndrome (HP:0001994)	3.90656725
20	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	3.86057329
21	Increased serum lactate (HP:0002151)	3.81083567
22	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.77915899
23	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.77915899
24	Pheochromocytoma (HP:0002666)	3.77750277
25	Increased intramyocellular lipid droplets (HP:0012240)	3.74137618
26	Optic disc pallor (HP:0000543)	3.56157115
27	Leukodystrophy (HP:0002415)	3.55064977
28	3-Methylglutaconic aciduria (HP:0003535)	3.51906682
29	Myokymia (HP:0002411)	3.43099029
30	Increased muscle lipid content (HP:0009058)	3.27865177
31	Abnormal protein glycosylation (HP:0012346)	3.27401595
32	Abnormal glycosylation (HP:0012345)	3.27401595
33	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	3.27401595
34	Abnormal protein N-linked glycosylation (HP:0012347)	3.27401595
35	Exertional dyspnea (HP:0002875)	3.19222047
36	Albinism (HP:0001022)	3.12185604
37	Emotional lability (HP:0000712)	3.09713876
38	Abnormality of cells of the erythroid lineage (HP:0012130)	2.96564824
39	Respiratory difficulties (HP:0002880)	2.90360648
40	CNS demyelination (HP:0007305)	2.86184388
41	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.81944825
42	Abnormality of alanine metabolism (HP:0010916)	2.81944825
43	Hyperalaninemia (HP:0003348)	2.81944825
44	Focal motor seizures (HP:0011153)	2.79708819
45	Stomatitis (HP:0010280)	2.76445158
46	Abnormality of glycosphingolipid metabolism (HP:0004343)	2.69871690
47	Abnormality of glycolipid metabolism (HP:0010969)	2.69871690
48	Abnormality of liposaccharide metabolism (HP:0010968)	2.69871690
49	Abnormal number of erythroid precursors (HP:0012131)	2.68105536
50	Microvesicular hepatic steatosis (HP:0001414)	2.63678595
51	Cerebral hypomyelination (HP:0006808)	2.61581629
52	Severe visual impairment (HP:0001141)	2.55407675
53	Neoplasm of the peripheral nervous system (HP:0100007)	2.51236575
54	Hypothermia (HP:0002045)	2.50960897
55	Congenital stationary night blindness (HP:0007642)	2.50830247
56	Reduced antithrombin III activity (HP:0001976)	2.49585194
57	Palpitations (HP:0001962)	2.46721157
58	Generalized aminoaciduria (HP:0002909)	2.46050667
59	Lethargy (HP:0001254)	2.45802131
60	Atonic seizures (HP:0010819)	2.41823962
61	Poor suck (HP:0002033)	2.41347029
62	Ragged-red muscle fibers (HP:0003200)	2.37475123
63	Cerebral hemorrhage (HP:0001342)	2.35919479
64	Abnormality of renal resorption (HP:0011038)	2.27377070
65	X-linked dominant inheritance (HP:0001423)	2.26506529
66	Delusions (HP:0000746)	2.21647279
67	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.21159508
68	Molar tooth sign on MRI (HP:0002419)	2.17771150
69	Abnormality of midbrain morphology (HP:0002418)	2.17771150
70	Poor head control (HP:0002421)	2.17602240
71	Ketoacidosis (HP:0001993)	2.17542638
72	Vacuolated lymphocytes (HP:0001922)	2.16284684
73	Pancreatic cysts (HP:0001737)	2.14488630
74	Limb dystonia (HP:0002451)	2.14399585
75	Myotonia (HP:0002486)	2.13523737
76	Pancytopenia (HP:0001876)	2.12668031
77	Gliosis (HP:0002171)	2.12608243
78	Opisthotonus (HP:0002179)	2.12361124
79	Abnormality of the vocal cords (HP:0008777)	2.12154774
80	Attenuation of retinal blood vessels (HP:0007843)	2.11400554
81	Abnormal rod and cone electroretinograms (HP:0008323)	2.08883262
82	Abnormal drinking behavior (HP:0030082)	2.05498508
83	Polydipsia (HP:0001959)	2.05498508
84	Ketosis (HP:0001946)	2.04135465
85	Abnormal gallbladder physiology (HP:0012438)	2.02125640
86	Cholecystitis (HP:0001082)	2.02125640
87	Progressive microcephaly (HP:0000253)	2.00236277
88	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.98008427
89	Hypoplasia of the fovea (HP:0007750)	1.98008427
90	Methylmalonic aciduria (HP:0012120)	1.96224543
91	Abnormal hair whorl (HP:0010721)	1.93094806
92	Macrocytic anemia (HP:0001972)	1.91566895
93	Glycosuria (HP:0003076)	1.90674934
94	Abnormality of urine glucose concentration (HP:0011016)	1.90674934
95	Progressive external ophthalmoplegia (HP:0000590)	1.90651221
96	Hyperphosphaturia (HP:0003109)	1.90292977
97	Unsteady gait (HP:0002317)	1.90158782
98	Elevated erythrocyte sedimentation rate (HP:0003565)	1.90059313
99	IgG deficiency (HP:0004315)	1.87458591
100	Abnormality of serum amino acid levels (HP:0003112)	1.87120538
101	Hyperventilation (HP:0002883)	1.83977143
102	Increased neuronal autofluorescent lipopigment (HP:0002074)	1.83321427
103	Aplastic anemia (HP:0001915)	1.82447802
104	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	1.81789630
105	Muscle hypertrophy of the lower extremities (HP:0008968)	1.79496932
106	Vomiting (HP:0002013)	1.79171305
107	Conjunctival hamartoma (HP:0100780)	1.78479521
108	Pancreatic fibrosis (HP:0100732)	1.78412858
109	Nausea (HP:0002018)	1.78311837
110	Petechiae (HP:0000967)	1.78194128
111	Pendular nystagmus (HP:0012043)	1.77286869
112	Large for gestational age (HP:0001520)	1.76633149
113	Congenital sensorineural hearing impairment (HP:0008527)	1.75868472
114	Abolished electroretinogram (ERG) (HP:0000550)	1.75758445
115	Hypokinesia (HP:0002375)	1.75173579
116	Sensory axonal neuropathy (HP:0003390)	1.75130507
117	Postnatal microcephaly (HP:0005484)	1.75035975
118	Hypomagnesemia (HP:0002917)	1.74976329
119	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.74565382
120	Abnormality of the anterior horn cell (HP:0006802)	1.72335467
121	Degeneration of anterior horn cells (HP:0002398)	1.72335467
122	CNS hypomyelination (HP:0003429)	1.71078931
123	Blindness (HP:0000618)	1.70996404
124	Calf muscle hypertrophy (HP:0008981)	1.70592784
125	Neoplasm of head and neck (HP:0012288)	1.70537090
126	Esophageal neoplasm (HP:0100751)	1.70537090
127	Microretrognathia (HP:0000308)	1.70361674
128	Rhabdomyolysis (HP:0003201)	1.69891085
129	Abnormality of the pons (HP:0007361)	1.69507742
130	Hypoplasia of the pons (HP:0012110)	1.68924332
131	Type I transferrin isoform profile (HP:0003642)	1.68826291
132	Tongue fasciculations (HP:0001308)	1.68757592
133	Cutaneous melanoma (HP:0012056)	1.68453147
134	Retinal dysplasia (HP:0007973)	1.67234804
135	Exercise-induced muscle cramps (HP:0003710)	1.67141464
136	Hyperglycinemia (HP:0002154)	1.66870548
137	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.66341688
138	Increased cerebral lipofuscin (HP:0011813)	1.65223122
139	Oral leukoplakia (HP:0002745)	1.64864698
140	Dicarboxylic aciduria (HP:0003215)	1.64750173
141	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.64750173
142	Metabolic acidosis (HP:0001942)	1.64435177
143	Tinnitus (HP:0000360)	1.64434482
144	Abnormality of the fovea (HP:0000493)	1.64141434
145	Abnormal pupillary function (HP:0007686)	1.63312223
146	Sudden death (HP:0001699)	1.62097875
147	Absence seizures (HP:0002121)	1.61688303
148	Renal tubular dysfunction (HP:0000124)	1.59941115
149	Anxiety (HP:0000739)	1.59195755
150	Muscle stiffness (HP:0003552)	1.56409251
151	Dialeptic seizures (HP:0011146)	1.56384185
152	Reticulocytopenia (HP:0001896)	1.55869947
153	Methylmalonic acidemia (HP:0002912)	1.51556445
154	Neoplasm of the adrenal gland (HP:0100631)	1.50707275
155	Type 2 muscle fiber atrophy (HP:0003554)	1.50434098
156	Respiratory insufficiency due to muscle weakness (HP:0002747)	1.49714193

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.22239339
2	MAP3K12	3.80825741
3	STK16	3.45951437
4	ARAF	3.29961598
5	NME2	2.74600874
6	MYLK	2.73971520
7	BUB1	2.67252397
8	VRK2	2.49362643
9	PDK2	2.47251266
10	NME1	2.35437177
11	TRIM28	2.33000423
12	CDK19	2.21137310
13	GRK5	2.18268733
14	CASK	2.10688805
15	TXK	2.08321149
16	LIMK1	2.03707289
17	NUAK1	1.94003510
18	BRAF	1.83294883
19	MAP2K7	1.79949869
20	EIF2AK1	1.79607079
21	PIM2	1.77219021
22	BCKDK	1.71625897
23	TESK1	1.70973750
24	TSSK6	1.69949942
25	GRK7	1.65179598
26	MAP4K2	1.64826618
27	TESK2	1.61375528
28	GRK1	1.57243438
29	DAPK1	1.55292386
30	CCNB1	1.47518968
31	WNK3	1.45677478
32	IKBKB	1.45563768
33	WEE1	1.43119338
34	OBSCN	1.42610193
35	BMPR1B	1.41653807
36	VRK1	1.38541961
37	MINK1	1.36178720
38	PLK2	1.31904696
39	EIF2AK3	1.31822418
40	MUSK	1.25270556
41	MARK3	1.24940212
42	TIE1	1.22413864
43	IRAK3	1.21572635
44	DAPK3	1.21115652
45	MAP3K11	1.21038541
46	KDR	1.18263636
47	OXSR1	1.17334980
48	RIPK4	1.15532232
49	NEK1	1.09930718
50	DAPK2	1.02712030
51	PRPF4B	0.98757151
52	ILK	0.98519798
53	PDK4	0.98290859
54	PDK3	0.98290859
55	TAOK3	0.98097387
56	ABL2	0.94362725
57	CDK8	0.93782399
58	CSNK1G1	0.93135923
59	CAMKK2	0.92824688
60	TNIK	0.92499725
61	TAOK2	0.92475546
62	MAP2K4	0.90739980
63	AURKA	0.89549575
64	TLK1	0.86040825
65	NTRK3	0.85680331
66	MAP3K9	0.84657089
67	BMPR2	0.84150057
68	PLK1	0.83865212
69	RAF1	0.82629360
70	PBK	0.82275693
71	MAP4K1	0.81963021
72	MAPKAPK5	0.81862744
73	MAP2K6	0.81489547
74	CDC7	0.80804533
75	ADRBK2	0.80302288
76	TEC	0.80068740
77	MST4	0.80031905
78	PTK2B	0.78176137
79	BRSK1	0.78116021
80	SIK3	0.77866422
81	PRKCI	0.77026255
82	CDK14	0.76491011
83	CAMK2G	0.76426162
84	SRPK1	0.76134614
85	GRK6	0.76083532
86	MAPKAPK3	0.72707573
87	PLK4	0.71486361
88	CSNK1A1L	0.70453641
89	MAP3K4	0.69162918
90	PINK1	0.69052863
91	CSNK1G3	0.69030049
92	MOS	0.68717458
93	CSNK1G2	0.68650635
94	CAMK2B	0.67975621
95	KSR2	0.67506204
96	RPS6KA5	0.67072837
97	MAP3K13	0.66501854
98	BCR	0.66198870
99	CDK18	0.65706093
100	MAP3K5	0.65634684
101	PIM1	0.64933153
102	CAMK2A	0.64082340
103	STK10	0.63484723
104	STK39	0.62428204
105	PAK1	0.60683027
106	MATK	0.60157802
107	CDK15	0.59824686
108	CAMK2D	0.58923530
109	BLK	0.58646551
110	CDK11A	0.58190347
111	TBK1	0.57835031
112	PAK3	0.57801826
113	PIK3CG	0.56769629
114	FES	0.55926083
115	ROCK2	0.55844531
116	ZAK	0.55626572
117	MAP3K3	0.55554499
118	MAPK13	0.55351776
119	IKBKE	0.55009756
120	PRKCG	0.54452861
121	WNK4	0.52551443
122	BRSK2	0.52027840
123	INSRR	0.50848021
124	SCYL2	0.50149128
125	DYRK2	0.48645671
126	PLK3	0.48507146
127	LYN	0.48389137
128	ADRBK1	0.47811426
129	EPHA4	0.47121813
130	MKNK2	0.46423540
131	ATR	0.44738955
132	CSNK2A1	0.44468814
133	PNCK	0.43123185
134	KIT	0.42950588
135	MAP2K3	0.42645566
136	TGFBR2	0.42507190
137	IRAK1	0.42443293
138	SYK	0.42308773
139	IRAK4	0.41610728
140	NTRK1	0.41138825
141	PRKCD	0.40948947
142	CSNK2A2	0.40433522
143	STK4	0.39975857
144	STK24	0.39767267
145	CSNK1A1	0.39590953
146	FLT3	0.39387998
147	UHMK1	0.38705922
148	PRKCQ	0.38646034
149	ACVR1B	0.38124850
150	PRKCE	0.35390922

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	5.91791121
2	Parkinsons disease_Homo sapiens_hsa05012	5.28918337
3	Proteasome_Homo sapiens_hsa03050	4.42304716
4	Ribosome_Homo sapiens_hsa03010	3.75066508
5	Alzheimers disease_Homo sapiens_hsa05010	3.67170280
6	Huntingtons disease_Homo sapiens_hsa05016	3.63070275
7	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.92941023
8	Cardiac muscle contraction_Homo sapiens_hsa04260	2.78186124
9	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	2.74354246
10	RNA polymerase_Homo sapiens_hsa03020	2.70926178
11	Collecting duct acid secretion_Homo sapiens_hsa04966	2.38922228
12	DNA replication_Homo sapiens_hsa03030	1.97560473
13	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.93433843
14	Pyrimidine metabolism_Homo sapiens_hsa00240	1.76486357
15	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.74473335
16	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.59335737
17	Mismatch repair_Homo sapiens_hsa03430	1.56183829
18	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.55476975
19	Protein export_Homo sapiens_hsa03060	1.50804550
20	Vibrio cholerae infection_Homo sapiens_hsa05110	1.40481879
21	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.32108967
22	Pyruvate metabolism_Homo sapiens_hsa00620	1.27627518
23	Carbon metabolism_Homo sapiens_hsa01200	1.25325284
24	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.22661579
25	Nucleotide excision repair_Homo sapiens_hsa03420	1.21777751
26	Selenocompound metabolism_Homo sapiens_hsa00450	1.20726650
27	Graft-versus-host disease_Homo sapiens_hsa05332	1.19020834
28	Sulfur relay system_Homo sapiens_hsa04122	1.16933911
29	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.16367974
30	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.12087717
31	Fanconi anemia pathway_Homo sapiens_hsa03460	1.11575603
32	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.11295828
33	Nicotine addiction_Homo sapiens_hsa05033	1.10724691
34	Allograft rejection_Homo sapiens_hsa05330	1.09030916
35	Purine metabolism_Homo sapiens_hsa00230	1.07928350
36	Type I diabetes mellitus_Homo sapiens_hsa04940	1.06969388
37	Tryptophan metabolism_Homo sapiens_hsa00380	1.06623807
38	Fatty acid elongation_Homo sapiens_hsa00062	1.04863278
39	Nitrogen metabolism_Homo sapiens_hsa00910	1.02667349
40	Primary immunodeficiency_Homo sapiens_hsa05340	1.01730830
41	Asthma_Homo sapiens_hsa05310	1.01697927
42	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.98756594
43	Spliceosome_Homo sapiens_hsa03040	0.97028687
44	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.96878626
45	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.95486997
46	Base excision repair_Homo sapiens_hsa03410	0.93487882
47	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.91743780
48	Lysosome_Homo sapiens_hsa04142	0.90606250
49	Phototransduction_Homo sapiens_hsa04744	0.90120545
50	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.88641998
51	Homologous recombination_Homo sapiens_hsa03440	0.88382079
52	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.87271135
53	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.86804191
54	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.85055362
55	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.84945622
56	Rheumatoid arthritis_Homo sapiens_hsa05323	0.83492712
57	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.83035195
58	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.82303140
59	Metabolic pathways_Homo sapiens_hsa01100	0.81619139
60	Glutathione metabolism_Homo sapiens_hsa00480	0.81456149
61	Propanoate metabolism_Homo sapiens_hsa00640	0.80760314
62	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.77883277
63	Steroid biosynthesis_Homo sapiens_hsa00100	0.74433959
64	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.73948404
65	RNA transport_Homo sapiens_hsa03013	0.73905612
66	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.73241376
67	Antigen processing and presentation_Homo sapiens_hsa04612	0.70548441
68	Phenylalanine metabolism_Homo sapiens_hsa00360	0.69509515
69	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.68437442
70	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.68306803
71	Pentose phosphate pathway_Homo sapiens_hsa00030	0.66899105
72	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.66804124
73	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.65543271
74	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.65374851
75	Legionellosis_Homo sapiens_hsa05134	0.63603370
76	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.63305746
77	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.61718020
78	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.60396006
79	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.60001001
80	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.59890500
81	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.58820279
82	Basal transcription factors_Homo sapiens_hsa03022	0.58661296
83	Caffeine metabolism_Homo sapiens_hsa00232	0.58624803
84	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.57258306
85	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.55193946
86	Tyrosine metabolism_Homo sapiens_hsa00350	0.54440026
87	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.54248890
88	Serotonergic synapse_Homo sapiens_hsa04726	0.53734873
89	Fatty acid metabolism_Homo sapiens_hsa01212	0.53226700
90	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.52143004
91	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.51382898
92	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.50711229
93	GABAergic synapse_Homo sapiens_hsa04727	0.49887723
94	Phagosome_Homo sapiens_hsa04145	0.49682535
95	Sphingolipid metabolism_Homo sapiens_hsa00600	0.49076983
96	Regulation of autophagy_Homo sapiens_hsa04140	0.47688145
97	Linoleic acid metabolism_Homo sapiens_hsa00591	0.46854424
98	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.46137004
99	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.45927869
100	Fatty acid degradation_Homo sapiens_hsa00071	0.45018413
101	RNA degradation_Homo sapiens_hsa03018	0.44224118
102	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.43333068
103	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.42793614
104	Morphine addiction_Homo sapiens_hsa05032	0.42193008
105	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.40299115
106	Dopaminergic synapse_Homo sapiens_hsa04728	0.38722575
107	Peroxisome_Homo sapiens_hsa04146	0.37800193
108	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.35400792
109	Folate biosynthesis_Homo sapiens_hsa00790	0.35303541
110	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.34884921
111	Amphetamine addiction_Homo sapiens_hsa05031	0.34455929
112	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.33419834
113	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.33035147
114	Olfactory transduction_Homo sapiens_hsa04740	0.32919408
115	Galactose metabolism_Homo sapiens_hsa00052	0.30551041
116	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.29326683
117	Sulfur metabolism_Homo sapiens_hsa00920	0.28520003
118	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.28024980
119	Long-term potentiation_Homo sapiens_hsa04720	0.27741035
120	Taste transduction_Homo sapiens_hsa04742	0.27091078
121	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.25047547
122	Oocyte meiosis_Homo sapiens_hsa04114	0.23239032
123	Circadian entrainment_Homo sapiens_hsa04713	0.20510734
124	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.19481206
125	Arginine and proline metabolism_Homo sapiens_hsa00330	0.19362354
126	Calcium signaling pathway_Homo sapiens_hsa04020	0.18702478
127	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.18065996
128	Thyroid cancer_Homo sapiens_hsa05216	0.15081225
129	Alcoholism_Homo sapiens_hsa05034	0.13889078
130	Chemical carcinogenesis_Homo sapiens_hsa05204	0.11571733
131	Butanoate metabolism_Homo sapiens_hsa00650	0.10503181
132	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.10394245
133	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.10291700
134	Glutamatergic synapse_Homo sapiens_hsa04724	0.09277732
135	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.09186236
136	One carbon pool by folate_Homo sapiens_hsa00670	0.09037188
137	Non-homologous end-joining_Homo sapiens_hsa03450	0.08583881
138	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.08368280

SMIM12

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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