SMIM14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)6.35623955
2COPI coating of Golgi vesicle (GO:0048205)6.35623955
3exogenous drug catabolic process (GO:0042738)5.97191790
4drug catabolic process (GO:0042737)5.54305756
5maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.36336677
6protein retention in ER lumen (GO:0006621)5.16677127
7regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022354.90461714
8epoxygenase P450 pathway (GO:0019373)4.67262236
9glucuronate metabolic process (GO:0019585)4.67018187
10uronic acid metabolic process (GO:0006063)4.67018187
11cellular glucuronidation (GO:0052695)4.62412373
12ethanol oxidation (GO:0006069)4.37512158
13omega-hydroxylase P450 pathway (GO:0097267)4.31133406
14ethanol metabolic process (GO:0006067)4.16712213
15axonemal dynein complex assembly (GO:0070286)4.14937994
16primary alcohol catabolic process (GO:0034310)4.10940345
17signal peptide processing (GO:0006465)3.97038731
18retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.95336949
19cellular ketone body metabolic process (GO:0046950)3.89157147
20cilium movement (GO:0003341)3.84673363
21epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.78377775
22cilium or flagellum-dependent cell motility (GO:0001539)3.70543624
23exocrine pancreas development (GO:0031017)3.70425301
24epithelial cilium movement (GO:0003351)3.70272278
25drug metabolic process (GO:0017144)3.70091002
26phenylpropanoid metabolic process (GO:0009698)3.68575971
27protein maturation by protein folding (GO:0022417)3.65472653
28COPII vesicle coating (GO:0048208)3.59261301
29ER overload response (GO:0006983)3.58123762
30bile acid biosynthetic process (GO:0006699)3.48688904
31glyoxylate metabolic process (GO:0046487)3.44430530
32ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.42911061
33oxidative demethylation (GO:0070989)3.41286162
34ketone body metabolic process (GO:1902224)3.39358809
35amino-acid betaine metabolic process (GO:0006577)3.37805089
36bile acid metabolic process (GO:0008206)3.36415205
37peptide hormone processing (GO:0016486)3.34033562
38flavonoid metabolic process (GO:0009812)3.31277443
39indole-containing compound catabolic process (GO:0042436)3.29829463
40indolalkylamine catabolic process (GO:0046218)3.29829463
41tryptophan catabolic process (GO:0006569)3.29829463
42activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.28457498
43pyrimidine nucleobase catabolic process (GO:0006208)3.27906924
44axoneme assembly (GO:0035082)3.25724694
45endocrine pancreas development (GO:0031018)3.24386490
46S-adenosylmethionine metabolic process (GO:0046500)3.23647805
47aromatic amino acid family catabolic process (GO:0009074)3.19679903
48bile acid and bile salt transport (GO:0015721)3.19489051
49benzene-containing compound metabolic process (GO:0042537)3.19252611
50nucleobase catabolic process (GO:0046113)3.16121461
51regulation of type B pancreatic cell apoptotic process (GO:2000674)3.15226718
52insulin secretion (GO:0030073)3.10621828
53protein targeting to Golgi (GO:0000042)3.10188498
54erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.08261649
55L-phenylalanine catabolic process (GO:0006559)3.08261649
56positive regulation of insulin secretion (GO:0032024)3.08173791
57vesicle coating (GO:0006901)3.06992387
58regulation of protein activation cascade (GO:2000257)3.06377192
59positive regulation of nuclease activity (GO:0032075)3.02747270
60intra-Golgi vesicle-mediated transport (GO:0006891)3.01885274
61retrograde transport, vesicle recycling within Golgi (GO:0000301)2.99862309
62detection of calcium ion (GO:0005513)2.98976507
63regulation of complement activation (GO:0030449)2.96205458
64alkaloid metabolic process (GO:0009820)2.95506941
65regulation of synaptic vesicle exocytosis (GO:2000300)2.95350373
66primary alcohol metabolic process (GO:0034308)2.94680546
67protein localization to cilium (GO:0061512)2.94070016
68type B pancreatic cell development (GO:0003323)2.92267286
69protein localization to Golgi apparatus (GO:0034067)2.90114026
70xenobiotic catabolic process (GO:0042178)2.87546066
71establishment of protein localization to Golgi (GO:0072600)2.86245545
72regulation of triglyceride catabolic process (GO:0010896)2.84910751
73glandular epithelial cell differentiation (GO:0002067)2.83206623
74sequestering of metal ion (GO:0051238)2.82428372
75macroautophagy (GO:0016236)2.77991113
76xenobiotic metabolic process (GO:0006805)2.77708018
77endoplasmic reticulum unfolded protein response (GO:0030968)2.77480540
78regulation of synaptic vesicle transport (GO:1902803)2.77427848
79drug transmembrane transport (GO:0006855)2.76983351
80indolalkylamine metabolic process (GO:0006586)2.75756529
81negative regulation of protein activation cascade (GO:2000258)2.73279849
82cellular response to unfolded protein (GO:0034620)2.72608974
83regulation of insulin secretion (GO:0050796)2.72432185
84ER-nucleus signaling pathway (GO:0006984)2.69998170
85complement activation, alternative pathway (GO:0006957)2.68901873
86regulation of nuclease activity (GO:0032069)2.68013140
87cellular response to topologically incorrect protein (GO:0035967)2.67928038
88tryptophan metabolic process (GO:0006568)2.67403144
89L-fucose catabolic process (GO:0042355)2.65686715
90fucose catabolic process (GO:0019317)2.65686715
91L-fucose metabolic process (GO:0042354)2.65686715
92triglyceride homeostasis (GO:0070328)2.64456337
93acylglycerol homeostasis (GO:0055090)2.64456337
94L-phenylalanine metabolic process (GO:0006558)2.64375555
95erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.64375555
96protein N-linked glycosylation via asparagine (GO:0018279)2.64359032
97positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.63604790
98synaptic vesicle maturation (GO:0016188)2.63366487
99positive regulation of peptide hormone secretion (GO:0090277)2.62362762
100coenzyme catabolic process (GO:0009109)2.61424611
101peptidyl-asparagine modification (GO:0018196)2.61142449
102positive regulation of peptide secretion (GO:0002793)2.59945964
1033-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.59488093
104purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.59488093
105prostate gland growth (GO:0060736)2.57048736
106negative regulation of complement activation (GO:0045916)2.56618552
107regulation of fibrinolysis (GO:0051917)2.54867337
108negative regulation of glycogen biosynthetic process (GO:0045719)2.54539554
109daunorubicin metabolic process (GO:0044597)2.50674364
110polyketide metabolic process (GO:0030638)2.50674364
111doxorubicin metabolic process (GO:0044598)2.50674364
112arginine metabolic process (GO:0006525)2.50144829
113regulation of peptide hormone secretion (GO:0090276)2.49882251
114water-soluble vitamin biosynthetic process (GO:0042364)2.49849216
115regulation of peptide secretion (GO:0002791)2.49208491
116ER to Golgi vesicle-mediated transport (GO:0006888)2.46148536
117kynurenine metabolic process (GO:0070189)2.45907705
118protein N-linked glycosylation (GO:0006487)2.45602689
119fucose metabolic process (GO:0006004)2.45511666
120aldehyde catabolic process (GO:0046185)2.44778163
121negative regulation of humoral immune response (GO:0002921)2.43845483
122regulation of calcium ion-dependent exocytosis (GO:0017158)2.43607872
123androgen metabolic process (GO:0008209)2.43305277
124regulation of ARF protein signal transduction (GO:0032012)2.43134956
125intestinal cholesterol absorption (GO:0030299)2.42478143
126fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.41090048
127response to endoplasmic reticulum stress (GO:0034976)2.40784364
128Golgi organization (GO:0007030)2.39216107
129regulation of short-term neuronal synaptic plasticity (GO:0048172)2.38619573
130positive regulation of vesicle fusion (GO:0031340)2.37833023
131glandular epithelial cell development (GO:0002068)2.37541738
132regulation of autophagic vacuole assembly (GO:2000785)2.36440938
133regulation of cilium movement (GO:0003352)2.35228099
134cilium organization (GO:0044782)2.35143141
135neurotransmitter metabolic process (GO:0042133)2.34297031
136complement activation, classical pathway (GO:0006958)2.34118675
137behavioral response to nicotine (GO:0035095)2.33987569
138negative regulation of glycoprotein biosynthetic process (GO:0010561)2.33694932
139positive regulation of exocytosis (GO:0045921)2.32871657
140intestinal epithelial cell development (GO:0060576)2.31270915
141toxin metabolic process (GO:0009404)2.31029802
142neurotransmitter biosynthetic process (GO:0042136)2.30917088
143synaptic vesicle exocytosis (GO:0016079)2.30256878
144regulation of steroid hormone secretion (GO:2000831)2.30106458
145cilium assembly (GO:0042384)2.30085960
146response to pheromone (GO:0019236)2.29985145
147response to nitrosative stress (GO:0051409)2.29766833
148regulation of beta-amyloid formation (GO:1902003)2.29483577
149peptide secretion (GO:0002790)2.28541789
150cellular response to glucagon stimulus (GO:0071377)2.28479779
151mitochondrial calcium ion transport (GO:0006851)2.28170253
152regulation of amyloid precursor protein catabolic process (GO:1902991)2.27870291
153regulation of hormone secretion (GO:0046883)2.26265891
154interleukin-1-mediated signaling pathway (GO:0070498)2.25061119
155neurotransmitter catabolic process (GO:0042135)2.24827149
156aminoglycoside antibiotic metabolic process (GO:0030647)2.23760105
157positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.23496699
158positive regulation of fatty acid beta-oxidation (GO:0032000)2.23086055
159quinone metabolic process (GO:1901661)2.22930789
160carnitine metabolic process (GO:0009437)2.22702380
161peptide hormone secretion (GO:0030072)2.22684418
162retinal metabolic process (GO:0042574)2.22204426
163Golgi vesicle transport (GO:0048193)2.21927527
164positive regulation of fatty acid oxidation (GO:0046321)2.21735902
165reflex (GO:0060004)2.21300205
166cilium morphogenesis (GO:0060271)2.20551763
167positive regulation of glycolytic process (GO:0045821)2.20069496
168regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.19993141
169indole-containing compound metabolic process (GO:0042430)2.19778270
170hormone catabolic process (GO:0042447)2.19761770
171negative regulation of glycogen metabolic process (GO:0070874)2.19472710
172retinol metabolic process (GO:0042572)2.19279879
173regulation of glucocorticoid secretion (GO:2000849)2.19133084
174androgen biosynthetic process (GO:0006702)2.19024251
175positive regulation of hormone secretion (GO:0046887)2.18492451
176regulation of exocytosis (GO:0017157)2.17907812
177N-glycan processing (GO:0006491)2.17605537
178fucosylation (GO:0036065)2.16311192
179magnesium ion transport (GO:0015693)2.14177771
180response to ischemia (GO:0002931)2.12562459
181positive regulation of regulated secretory pathway (GO:1903307)2.08395962
182activation of protein kinase A activity (GO:0034199)2.07860606
183GDP-mannose metabolic process (GO:0019673)2.07320042
184nucleoside diphosphate catabolic process (GO:0009134)2.07111899
185relaxation of cardiac muscle (GO:0055119)2.05455047
186regulation of corticosteroid hormone secretion (GO:2000846)2.03880615
187UDP-N-acetylglucosamine metabolic process (GO:0006047)2.03739834
188regulation of peptide transport (GO:0090087)2.02992173
189response to redox state (GO:0051775)2.02832980
190glutamate secretion (GO:0014047)2.02764288
191peptide transport (GO:0015833)2.02747344
192negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.01241624
193response to unfolded protein (GO:0006986)2.00835576
194regulation of vesicle fusion (GO:0031338)2.00465951
195pyrimidine ribonucleoside catabolic process (GO:0046133)2.00118335
196positive regulation of synaptic transmission, GABAergic (GO:0032230)1.99770608
197digestion (GO:0007586)1.99102001

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human2.63842551
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.37830328
3GATA1_22025678_ChIP-Seq_K562_Human2.11886083
4EGR1_23403033_ChIP-Seq_LIVER_Mouse1.94630798
5ER_23166858_ChIP-Seq_MCF-7_Human1.92374421
6GBX2_23144817_ChIP-Seq_PC3_Human1.89448415
7TAF15_26573619_Chip-Seq_HEK293_Human1.80267063
8VDR_22108803_ChIP-Seq_LS180_Human1.78671723
9FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.77324878
10IRF8_22096565_ChIP-ChIP_GC-B_Human1.76265820
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.73242335
12SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.71895243
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.61791945
14MTF2_20144788_ChIP-Seq_MESCs_Mouse1.61256367
15SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.58597388
16SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.56858315
17CDX2_19796622_ChIP-Seq_MESCs_Mouse1.56249292
18NR3C1_23031785_ChIP-Seq_PC12_Mouse1.54420002
19FOXM1_26456572_ChIP-Seq_MCF-7_Human1.53918534
20ZNF217_24962896_ChIP-Seq_MCF-7_Human1.52454722
21PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.52120015
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.49315942
23CTBP1_25329375_ChIP-Seq_LNCAP_Human1.48034132
24DROSHA_22980978_ChIP-Seq_HELA_Human1.46007891
25SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.39750269
26REST_21632747_ChIP-Seq_MESCs_Mouse1.37452074
27GATA2_21666600_ChIP-Seq_HMVEC_Human1.33959822
28SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.33622690
29IGF1R_20145208_ChIP-Seq_DFB_Human1.31611296
30PCGF2_27294783_Chip-Seq_ESCs_Mouse1.30451873
31EZH2_27294783_Chip-Seq_ESCs_Mouse1.29337863
32PIAS1_25552417_ChIP-Seq_VCAP_Human1.28751339
33EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.27493375
34LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.24927616
35TCF4_22108803_ChIP-Seq_LS180_Human1.24652773
36AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24394215
37SMAD_19615063_ChIP-ChIP_OVARY_Human1.24188716
38SUZ12_27294783_Chip-Seq_ESCs_Mouse1.22978177
39TRIM28_21343339_ChIP-Seq_HEK293_Human1.22528933
40JARID2_20075857_ChIP-Seq_MESCs_Mouse1.21012990
41CDX2_22108803_ChIP-Seq_LS180_Human1.20801816
42SMAD4_21799915_ChIP-Seq_A2780_Human1.20610774
43SMAD3_21741376_ChIP-Seq_EPCs_Human1.20537715
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.19627541
45ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.17814518
46UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17803310
47PCGF2_27294783_Chip-Seq_NPCs_Mouse1.17551426
48SUZ12_27294783_Chip-Seq_NPCs_Mouse1.16400608
49TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.16003455
50RNF2_18974828_ChIP-Seq_MESCs_Mouse1.15971676
51EZH2_18974828_ChIP-Seq_MESCs_Mouse1.15971676
52NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.15799354
53FUS_26573619_Chip-Seq_HEK293_Human1.15016814
54CBP_20019798_ChIP-Seq_JUKART_Human1.14643502
55IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14643502
56CJUN_26792858_Chip-Seq_BT549_Human1.13206512
57TP53_18474530_ChIP-ChIP_U2OS_Human1.13110560
58IKZF1_21737484_ChIP-ChIP_HCT116_Human1.13086222
59RUNX2_22187159_ChIP-Seq_PCA_Human1.12991979
60STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.12615038
61AR_25329375_ChIP-Seq_VCAP_Human1.11473664
62CDX2_20551321_ChIP-Seq_CACO-2_Human1.10947901
63REST_18959480_ChIP-ChIP_MESCs_Mouse1.10703844
64ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.10113062
65NFE2_27457419_Chip-Seq_LIVER_Mouse1.09226058
66JARID2_20064375_ChIP-Seq_MESCs_Mouse1.09011294
67GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08877073
68PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.08706722
69IRF1_19129219_ChIP-ChIP_H3396_Human1.08429523
70NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.08359222
71NRF2_20460467_ChIP-Seq_MEFs_Mouse1.08359222
72MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07859338
73ESR1_20079471_ChIP-ChIP_T-47D_Human1.07644748
74SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.07273986
75VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.06093485
76TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05820977
77EZH2_27294783_Chip-Seq_NPCs_Mouse1.04134917
78P53_22387025_ChIP-Seq_ESCs_Mouse1.03578684
79ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03153771
80BMI1_23680149_ChIP-Seq_NPCS_Mouse1.02134936
81ARNT_22903824_ChIP-Seq_MCF-7_Human1.02067644
82RNF2_27304074_Chip-Seq_ESCs_Mouse1.01306964
83SMAD4_21741376_ChIP-Seq_EPCs_Human1.00915097
84AR_21572438_ChIP-Seq_LNCaP_Human1.00591800
85DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.00550516
86SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.00317898
87FOXA1_21572438_ChIP-Seq_LNCaP_Human1.00185124
88AHR_22903824_ChIP-Seq_MCF-7_Human1.00070653
89RARB_27405468_Chip-Seq_BRAIN_Mouse0.99948779
90EWS_26573619_Chip-Seq_HEK293_Human0.99821395
91BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99799209
92SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99337146
93STAT3_23295773_ChIP-Seq_U87_Human0.99063086
94ZFP57_27257070_Chip-Seq_ESCs_Mouse0.99053492
95RXR_22158963_ChIP-Seq_LIVER_Mouse0.98837327
96KLF5_20875108_ChIP-Seq_MESCs_Mouse0.98823885
97FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.98327224
98EP300_21415370_ChIP-Seq_HL-1_Mouse0.97685747
99GATA4_25053715_ChIP-Seq_YYC3_Human0.96220972
100FOXA1_25552417_ChIP-Seq_VCAP_Human0.96210486
101NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.96150682
102CTBP2_25329375_ChIP-Seq_LNCAP_Human0.95517987
103AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.95172337
104FOXA1_27270436_Chip-Seq_PROSTATE_Human0.95137341
105FOXA1_25329375_ChIP-Seq_VCAP_Human0.95137341
106NANOG_19829295_ChIP-Seq_ESCs_Human0.94997034
107SOX2_19829295_ChIP-Seq_ESCs_Human0.94997034
108SOX2_20726797_ChIP-Seq_SW620_Human0.94498999
109ZNF274_21170338_ChIP-Seq_K562_Hela0.94401901
110LXR_22158963_ChIP-Seq_LIVER_Mouse0.94258821
111CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.94167348
112KDM2B_26808549_Chip-Seq_REH_Human0.92781082
113* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.89808334
114SOX2_21211035_ChIP-Seq_LN229_Gbm0.89459759
115FLI1_21867929_ChIP-Seq_TH2_Mouse0.87762703
116BCAT_22108803_ChIP-Seq_LS180_Human0.87539304
117P300_19829295_ChIP-Seq_ESCs_Human0.87324842
118ESR1_21235772_ChIP-Seq_MCF-7_Human0.87087664
119NANOG_18555785_Chip-Seq_ESCs_Mouse0.86938341
120FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.86877040
121OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84907552
122SOX2_27498859_Chip-Seq_STOMACH_Mouse0.84256564
123TOP2B_26459242_ChIP-Seq_MCF-7_Human0.83936177
124FOXA2_19822575_ChIP-Seq_HepG2_Human0.83494226
125BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.82988757
126Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.82704406
127EED_16625203_ChIP-ChIP_MESCs_Mouse0.82494308
128NR3C1_21868756_ChIP-Seq_MCF10A_Human0.82428292
129E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.82040616
130MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.81667918
131TCF4_23295773_ChIP-Seq_U87_Human0.80526598
132RUNX_20019798_ChIP-Seq_JUKART_Human0.80427269
133SPI1_23127762_ChIP-Seq_K562_Human0.79808152
134EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.79273869
135ESR2_21235772_ChIP-Seq_MCF-7_Human0.78970809
136ERG_20517297_ChIP-Seq_VCAP_Human0.78267757
137SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.77446556
138RXR_22108803_ChIP-Seq_LS180_Human0.77192151
139TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.77101668
140SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.76971978
141CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.76733701
142MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.76524933
143EZH2_27304074_Chip-Seq_ESCs_Mouse0.75820206
144MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.74702329

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010386_abnormal_urinary_bladder3.53458864
2MP0002909_abnormal_adrenal_gland3.41353800
3MP0003183_abnormal_peptide_metabolism3.19677149
4MP0009780_abnormal_chondrocyte_physiolo2.96228034
5MP0002693_abnormal_pancreas_physiology2.88899296
6MP0000013_abnormal_adipose_tissue2.86264248
7MP0005646_abnormal_pituitary_gland2.59926250
8MP0001944_abnormal_pancreas_morphology2.57019176
9MP0004043_abnormal_pH_regulation2.52138126
10MP0003195_calcinosis2.39128293
11MP0010329_abnormal_lipoprotein_level2.36722384
12MP0005220_abnormal_exocrine_pancreas2.34391577
13MP0002877_abnormal_melanocyte_morpholog2.20788927
14MP0005360_urolithiasis2.12866307
15MP0005058_abnormal_lysosome_morphology2.12497529
16MP0005379_endocrine/exocrine_gland_phen2.11783432
17MP0001986_abnormal_taste_sensitivity2.07756518
18MP0004859_abnormal_synaptic_plasticity2.04888761
19MP0005365_abnormal_bile_salt1.98568768
20MP0002837_dystrophic_cardiac_calcinosis1.92068258
21MP0003011_delayed_dark_adaptation1.88340442
22MP0005310_abnormal_salivary_gland1.87394777
23MP0003283_abnormal_digestive_organ1.83378459
24MP0004270_analgesia1.81721760
25MP0001765_abnormal_ion_homeostasis1.72071059
26MP0008872_abnormal_physiological_respon1.70615726
27MP0002078_abnormal_glucose_homeostasis1.69167443
28MP0005332_abnormal_amino_acid1.68878184
29MP0001666_abnormal_nutrient_absorption1.66441330
30MP0000427_abnormal_hair_cycle1.63688509
31MP0009046_muscle_twitch1.63401775
32MP0003868_abnormal_feces_composition1.63296388
33MP0000003_abnormal_adipose_tissue1.59528149
34MP0004510_myositis1.54713610
35MP0002876_abnormal_thyroid_physiology1.53553881
36MP0001502_abnormal_circadian_rhythm1.53244622
37MP0005645_abnormal_hypothalamus_physiol1.51916642
38MP0004019_abnormal_vitamin_homeostasis1.50575005
39MP0000678_abnormal_parathyroid_gland1.50130296
40MP0005084_abnormal_gallbladder_morpholo1.48055728
41MP0003172_abnormal_lysosome_physiology1.45201882
42MP0003635_abnormal_synaptic_transmissio1.41015254
43MP0001968_abnormal_touch/_nociception1.40427899
44MP0003300_gastrointestinal_ulcer1.39333505
45MP0005551_abnormal_eye_electrophysiolog1.39055177
46MP0002735_abnormal_chemical_nociception1.38020958
47MP0002928_abnormal_bile_duct1.37753948
48MP0002734_abnormal_mechanical_nocicepti1.33262544
49MP0003787_abnormal_imprinting1.32368828
50MP0002733_abnormal_thermal_nociception1.27917723
51MP0002653_abnormal_ependyma_morphology1.23495452
52MP0002139_abnormal_hepatobiliary_system1.23265154
53MP0003252_abnormal_bile_duct1.21070173
54MP0003953_abnormal_hormone_level1.20951126
55MP0000639_abnormal_adrenal_gland1.20896317
56MP0002736_abnormal_nociception_after1.20830124
57MP0001970_abnormal_pain_threshold1.20660239
58MP0010234_abnormal_vibrissa_follicle1.19602350
59MP0005535_abnormal_body_temperature1.16628748
60MP0005503_abnormal_tendon_morphology1.13808171
61MP0008961_abnormal_basal_metabolism1.12624700
62MP0000383_abnormal_hair_follicle1.10597690
63MP0002822_catalepsy1.10032135
64MP0009643_abnormal_urine_homeostasis1.09971922
65MP0002009_preneoplasia1.08194880
66MP0006276_abnormal_autonomic_nervous1.06600219
67MP0003866_abnormal_defecation1.06482899
68MP0001485_abnormal_pinna_reflex1.05520042
69MP0004885_abnormal_endolymph1.05269232
70MP0001664_abnormal_digestion1.04767798
71MP0000230_abnormal_systemic_arterial1.04220963
72MP0002272_abnormal_nervous_system1.04132698
73MP0010678_abnormal_skin_adnexa1.02737339
74MP0002166_altered_tumor_susceptibility1.02545335
75MP0001756_abnormal_urination1.01416335
76MP0004133_heterotaxia1.00906672
77MP0006072_abnormal_retinal_apoptosis1.00606362
78MP0003879_abnormal_hair_cell1.00536777
79MP0004264_abnormal_extraembryonic_tissu1.00439131
80MP0002063_abnormal_learning/memory/cond1.00332680
81MP0003329_amyloid_beta_deposits1.00073050
82MP0002638_abnormal_pupillary_reflex1.00066773
83MP0001501_abnormal_sleep_pattern0.99637302
84MP0000613_abnormal_salivary_gland0.99195114
85MP0000538_abnormal_urinary_bladder0.98195511
86MP0009745_abnormal_behavioral_response0.98187410
87MP0000681_abnormal_thyroid_gland0.98073231
88MP0002572_abnormal_emotion/affect_behav0.98001777
89MP0005636_abnormal_mineral_homeostasis0.96155972
90MP0002102_abnormal_ear_morphology0.95804199
91MP0002168_other_aberrant_phenotype0.94241849
92MP0005253_abnormal_eye_physiology0.92299544
93MP0001486_abnormal_startle_reflex0.91937053
94MP0002282_abnormal_trachea_morphology0.91855659
95MP0005083_abnormal_biliary_tract0.91330994
96MP0002118_abnormal_lipid_homeostasis0.91107095
97MP0000462_abnormal_digestive_system0.91052575
98MP0001984_abnormal_olfaction0.90830876
99MP0002064_seizures0.89523154
100MP0003633_abnormal_nervous_system0.89449975
101MP0002557_abnormal_social/conspecific_i0.88698925
102MP0000569_abnormal_digit_pigmentation0.88492252
103MP0001873_stomach_inflammation0.87549402
104MP0002277_abnormal_respiratory_mucosa0.82506810
105MP0004142_abnormal_muscle_tone0.82037475
106MP0001835_abnormal_antigen_presentation0.81543042
107MP0004883_abnormal_blood_vessel0.80827841
108MP0002136_abnormal_kidney_physiology0.80721104
109MP0001270_distended_abdomen0.79763173
110MP0002138_abnormal_hepatobiliary_system0.79550510
111MP0001790_abnormal_immune_system0.78838584
112MP0005387_immune_system_phenotype0.78838584
113MP0003880_abnormal_central_pattern0.78222561
114MP0008569_lethality_at_weaning0.76419173
115MP0004782_abnormal_surfactant_physiolog0.75813865
116MP0001764_abnormal_homeostasis0.75732151
117MP0002163_abnormal_gland_morphology0.75617139
118MP0002067_abnormal_sensory_capabilities0.74752768
119MP0005448_abnormal_energy_balance0.73940900
120MP0001440_abnormal_grooming_behavior0.73095256
121MP0001905_abnormal_dopamine_level0.71666941
122MP0003959_abnormal_lean_body0.70224405
123MP0004147_increased_porphyrin_level0.69149452
124MP0003045_fibrosis0.68737584
125MP0005085_abnormal_gallbladder_physiolo0.68707310
126MP0002160_abnormal_reproductive_system0.68332703
127MP0002896_abnormal_bone_mineralization0.67924554
128MP0000631_abnormal_neuroendocrine_gland0.66877762
129MP0000604_amyloidosis0.66778817
130MP0005275_abnormal_skin_tensile0.66689966
131MP0008875_abnormal_xenobiotic_pharmacok0.66067406
132MP0004924_abnormal_behavior0.65972750
133MP0005386_behavior/neurological_phenoty0.65972750
134MP0005408_hypopigmentation0.64591736
135MP0003638_abnormal_response/metabolism_0.64431734

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic seizures (HP:0002173)5.02879796
2Abnormal respiratory motile cilium morphology (HP:0005938)4.61991430
3Abnormal respiratory epithelium morphology (HP:0012253)4.61991430
4Hyperinsulinemic hypoglycemia (HP:0000825)4.47698329
5Symptomatic seizures (HP:0011145)4.43336625
6Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.32811532
7Dysostosis multiplex (HP:0000943)4.30680490
8Abnormal ciliary motility (HP:0012262)4.29766459
9Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.29171726
10Hypoglycemic coma (HP:0001325)4.22900504
11Abnormal respiratory motile cilium physiology (HP:0012261)4.17568044
12Dynein arm defect of respiratory motile cilia (HP:0012255)4.14517381
13Absent/shortened dynein arms (HP:0200106)4.14517381
14Rhinitis (HP:0012384)4.13614310
15Urinary glycosaminoglycan excretion (HP:0003541)4.10690969
16Mucopolysacchariduria (HP:0008155)4.10690969
17Abnormality of mucopolysaccharide metabolism (HP:0011020)4.07403214
18Abnormality of polysaccharide metabolism (HP:0011012)4.07403214
19Abnormality of glycosaminoglycan metabolism (HP:0004371)4.07403214
20Hyperventilation (HP:0002883)4.03965709
21Abnormality of monocarboxylic acid metabolism (HP:0010996)3.79003036
22Pancreatic cysts (HP:0001737)3.58880688
23Insulin-resistant diabetes mellitus (HP:0000831)3.54268472
24Pancreatic fibrosis (HP:0100732)3.36467425
25True hermaphroditism (HP:0010459)3.32344390
26Ketoacidosis (HP:0001993)3.26307830
27Papilledema (HP:0001085)3.24487801
28Hypothermia (HP:0002045)3.22800454
29Complement deficiency (HP:0004431)3.18920791
30Abnormality of calcium-phosphate metabolism (HP:0100530)3.18547921
31Medial flaring of the eyebrow (HP:0010747)3.13635943
32Decreased circulating renin level (HP:0003351)3.07554864
33Abnormality of the intrinsic pathway (HP:0010989)3.07210468
34Vacuolated lymphocytes (HP:0001922)3.06858943
35Generalized aminoaciduria (HP:0002909)3.05228349
36Abnormality of the renal cortex (HP:0011035)3.04324222
37Abnormality of midbrain morphology (HP:0002418)3.01353165
38Molar tooth sign on MRI (HP:0002419)3.01353165
39Chronic sinusitis (HP:0011109)3.01309573
40Bronchiectasis (HP:0002110)3.00261725
41Chronic hepatic failure (HP:0100626)2.99508830
42Hyperglycemia (HP:0003074)2.86931893
43Abnormality of aromatic amino acid family metabolism (HP:0004338)2.86860769
44Nephronophthisis (HP:0000090)2.85913247
45Gait imbalance (HP:0002141)2.83206570
46Agitation (HP:0000713)2.78159925
47Abnormality of the pancreatic islet cells (HP:0006476)2.77950733
48Abnormality of endocrine pancreas physiology (HP:0012093)2.77950733
49Congenital primary aphakia (HP:0007707)2.70980220
50Visual hallucinations (HP:0002367)2.70888178
51Chronic bronchitis (HP:0004469)2.64407814
52Abnormality of the renal medulla (HP:0100957)2.62380290
53Nephrogenic diabetes insipidus (HP:0009806)2.61270586
54Tubular atrophy (HP:0000092)2.61202656
55Abnormality of glutamine family amino acid metabolism (HP:0010902)2.60802612
56Late onset (HP:0003584)2.59596810
57Fat malabsorption (HP:0002630)2.55247818
58Prolonged partial thromboplastin time (HP:0003645)2.55217566
59Progressive neurologic deterioration (HP:0002344)2.49713083
60Cystic liver disease (HP:0006706)2.49401506
61Recurrent sinusitis (HP:0011108)2.47010029
62Intrahepatic cholestasis (HP:0001406)2.45109459
63Hypobetalipoproteinemia (HP:0003563)2.43363437
64Metabolic alkalosis (HP:0200114)2.42307670
65Abnormal pancreas size (HP:0012094)2.42081597
66Growth hormone excess (HP:0000845)2.40054420
67Bile duct proliferation (HP:0001408)2.37813022
68Abnormal biliary tract physiology (HP:0012439)2.37813022
69Glomerulonephritis (HP:0000099)2.34423407
70Agammaglobulinemia (HP:0004432)2.33969325
71Hyperaldosteronism (HP:0000859)2.32029416
72Bronchitis (HP:0012387)2.31579575
73Conjugated hyperbilirubinemia (HP:0002908)2.31432448
74Fair hair (HP:0002286)2.31022187
75Beaking of vertebral bodies (HP:0004568)2.30541218
76Renal cortical cysts (HP:0000803)2.29679689
77Pancreatic islet-cell hyperplasia (HP:0004510)2.26932703
78Pheochromocytoma (HP:0002666)2.24528638
79Abnormal delayed hypersensitivity skin test (HP:0002963)2.24430386
80Alkalosis (HP:0001948)2.24144276
81Ketosis (HP:0001946)2.24117129
82Hyperphosphatemia (HP:0002905)2.24111330
83Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.21447147
84Large for gestational age (HP:0001520)2.20272194
85Abnormality of complement system (HP:0005339)2.19606751
86Absent speech (HP:0001344)2.19273579
87Hydroxyprolinuria (HP:0003080)2.17378722
88Abnormality of proline metabolism (HP:0010907)2.17378722
89Male pseudohermaphroditism (HP:0000037)2.16457043
90Abnormality of renin-angiotensin system (HP:0000847)2.14437943
91Hyperglycinuria (HP:0003108)2.12267970
92Furrowed tongue (HP:0000221)2.12119728
93Oligomenorrhea (HP:0000876)2.10772334
94Concave nail (HP:0001598)2.10497326
95Occipital encephalocele (HP:0002085)2.10216227
96Genital tract atresia (HP:0001827)2.10053508
97Recurrent bronchitis (HP:0002837)2.09010161
98Retinal atrophy (HP:0001105)2.08617386
99Exocrine pancreatic insufficiency (HP:0001738)2.07590399
100EEG with generalized epileptiform discharges (HP:0011198)2.06991396
101Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.06298907
102Abnormal protein N-linked glycosylation (HP:0012347)2.06298907
103Abnormal protein glycosylation (HP:0012346)2.06298907
104Abnormal glycosylation (HP:0012345)2.06298907
105Vaginal atresia (HP:0000148)2.06255552
106Tubulointerstitial nephritis (HP:0001970)2.05893211
107Hypokalemia (HP:0002900)2.05771252
108Nephritis (HP:0000123)2.05019712
109Neuroendocrine neoplasm (HP:0100634)2.03570467
110Keratoconus (HP:0000563)2.02045281
111Increased corneal curvature (HP:0100692)2.02045281
112Epileptiform EEG discharges (HP:0011182)2.01994426
113Steatorrhea (HP:0002570)2.01510861
114Hypsarrhythmia (HP:0002521)2.01323907
115Aplasia/Hypoplasia of the tongue (HP:0010295)2.00154020
116Hyperactive renin-angiotensin system (HP:0000841)1.99221898
117Supranuclear gaze palsy (HP:0000605)1.99011706
118Spondylolisthesis (HP:0003302)1.98036676
119Type II lissencephaly (HP:0007260)1.96565339
120Irregular vertebral endplates (HP:0003301)1.96368043
121Abnormality of vitamin metabolism (HP:0100508)1.96313224
122Limb hypertonia (HP:0002509)1.94646942
123Abnormality of liposaccharide metabolism (HP:0010968)1.94592797
124Abnormality of glycosphingolipid metabolism (HP:0004343)1.94592797
125Abnormality of glycolipid metabolism (HP:0010969)1.94592797
126Abnormality of the common coagulation pathway (HP:0010990)1.93470178
127Hyperlipoproteinemia (HP:0010980)1.93241331
128Vascular calcification (HP:0004934)1.89381255
129Congenital, generalized hypertrichosis (HP:0004540)1.88920821
130Spinal canal stenosis (HP:0003416)1.86169469
131Inability to walk (HP:0002540)1.85625384
132Cardiovascular calcification (HP:0011915)1.85300066
133Hyperparathyroidism (HP:0000843)1.85032793
134Renal salt wasting (HP:0000127)1.84936117
135Delayed CNS myelination (HP:0002188)1.84930987
136Action tremor (HP:0002345)1.84911250
137Torticollis (HP:0000473)1.84699509
138Poor coordination (HP:0002370)1.84330994
139Tubulointerstitial fibrosis (HP:0005576)1.84196465
140Decreased central vision (HP:0007663)1.84142379
141Focal motor seizures (HP:0011153)1.83960724
142Abnormality of serine family amino acid metabolism (HP:0010894)1.83409322
143Abnormality of glycine metabolism (HP:0010895)1.83409322
144Spontaneous abortion (HP:0005268)1.82768873
145Arterial tortuosity (HP:0005116)1.82032766
146Neurofibrillary tangles (HP:0002185)1.81849168
147Congenital stationary night blindness (HP:0007642)1.80900060
148Thoracolumbar scoliosis (HP:0002944)1.79834119
149Insulin resistance (HP:0000855)1.79403854
150Proximal tubulopathy (HP:0000114)1.79179189
151Limb dystonia (HP:0002451)1.78911012
152Infertility (HP:0000789)1.78514719
153Systemic lupus erythematosus (HP:0002725)1.78152577
154Retinal dysplasia (HP:0007973)1.77597039
155Tubulointerstitial abnormality (HP:0001969)1.77374470
156Barrel-shaped chest (HP:0001552)1.76353395
157Vascular tortuosity (HP:0004948)1.76349794
158Increased cerebral lipofuscin (HP:0011813)1.76066403
159Progressive cerebellar ataxia (HP:0002073)1.75621074
160Anxiety (HP:0000739)1.74674496
161Abolished electroretinogram (ERG) (HP:0000550)1.74210942
162Congenital hepatic fibrosis (HP:0002612)1.73652639
163Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.71756585
164Abnormality of potassium homeostasis (HP:0011042)1.70857166
165Abnormal drinking behavior (HP:0030082)1.70560683
166Increased neuronal autofluorescent lipopigment (HP:0002074)1.69713844
167Epiphyseal stippling (HP:0010655)1.68520300
168Mitral stenosis (HP:0001718)1.68417189
169Hypercortisolism (HP:0001578)1.64914745
170Abnormality of the fovea (HP:0000493)1.64132809
171Myokymia (HP:0002411)1.64130268
172Nonprogressive disorder (HP:0003680)1.62923174
173Failure to thrive in infancy (HP:0001531)1.62684519
174Long toe (HP:0010511)1.62656384
175Craniofacial dystonia (HP:0012179)1.62473721
176Disproportionate short-trunk short stature (HP:0003521)1.61746204
177Generalized hypopigmentation of hair (HP:0011358)1.61470002
178Acne (HP:0001061)1.60445565
179Focal dystonia (HP:0004373)1.59958073
180Asymmetric septal hypertrophy (HP:0001670)1.58007330
181Abnormality of the vertebral endplates (HP:0005106)1.55605666
182Epileptic encephalopathy (HP:0200134)1.55518092
183Abdominal distention (HP:0003270)1.55436388
184Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.55279640
185Gout (HP:0001997)1.55194524
186Hyperkalemia (HP:0002153)1.54727303

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR4.45993864
2TAOK33.91028470
3ACVR1B3.31411463
4CASK3.25900382
5ERN12.75195930
6MAP3K132.48512586
7KSR22.35329096
8ARAF2.26825013
9PRKD32.26137699
10CAMKK22.23470494
11GRK12.22722872
12MAP3K92.15635808
13MAP4K22.09067276
14BMPR1B2.08222335
15MAPK152.05711029
16STK392.01702940
17MST42.00484919
18NTRK31.96713143
19FRK1.94348623
20ADRBK21.93343919
21OXSR11.88424874
22HIPK21.87146849
23WNK31.86657713
24MAP3K21.85723174
25PASK1.80262006
26FLT31.80241915
27NTRK11.79049017
28BCR1.77003177
29STK38L1.71766775
30STK241.71566606
31BMPR21.47440473
32MAP3K121.40693722
33MARK11.40614690
34CAMKK11.36575302
35MAP3K11.33367592
36BCKDK1.28560855
37MAP2K71.28307848
38ERBB31.27650896
39PRKCH1.24545163
40MUSK1.24035783
41FGFR21.22320714
42PRKD21.21085677
43MAPKAPK31.15499819
44RIPK41.13970317
45TLK11.12860323
46SGK21.10624796
47RAF11.07947275
48PIK3CG1.07878627
49MYLK1.06600963
50SGK4941.03743366
51SGK2231.03743366
52BRAF1.02409534
53TEC1.02144641
54MAPK131.01394065
55TNK21.00837716
56MAP3K40.99860721
57EPHA20.97204269
58RET0.96593097
59KIT0.94391346
60SCYL20.94267180
61LIMK10.93848507
62ADRBK10.93693031
63EPHA40.93312302
64NEK90.90953353
65PRKCG0.88670932
66AKT30.87964659
67TRIM280.86178265
68CHUK0.85047625
69SGK30.78338457
70NUAK10.77699531
71PRKCI0.77242151
72WNK40.76596145
73PRKCZ0.75873093
74MAP2K40.72929890
75PAK30.72460680
76IRAK30.71522369
77SYK0.71489795
78EPHA30.70866614
79MAP2K10.70237712
80TAOK10.69525724
81BTK0.68665938
82CSNK1G20.68155980
83RPS6KA20.67766367
84JAK10.66680700
85SIK30.66665602
86MINK10.66635752
87EIF2AK30.66186046
88JAK30.65495418
89CDC42BPA0.64299452
90ERBB20.64052272
91PDK10.63549931
92PRKAA20.62681852
93PINK10.62372068
94MOS0.62330479
95NEK60.61973212
96PDPK10.60728925
97SIK10.60447259
98PRKCE0.60402713
99KSR10.58875166
100MAPKAPK50.58774230
101MARK20.58309963
102CDK50.56852557
103STK30.56823834
104PHKG20.56710221
105PHKG10.56710221
106FES0.56690886
107JAK20.55852425
108DAPK20.55115538
109TNIK0.54271247
110PIK3CA0.53893690
111PAK60.51658752
112CDK80.51640600
113TGFBR10.51425995
114DMPK0.51126684
115FGFR30.51023333
116TESK10.50212526
117PRKCQ0.50192137
118CAMK2D0.49700521
119ZAP700.49037699
120CSF1R0.48578935
121CSNK1A10.48242338
122NLK0.48166001
123PRKACA0.47790779
124CAMK2A0.47336910
125CAMK10.46881629
126UHMK10.46026633
127PRKD10.45532034
128MAP3K70.45376739
129FER0.45336283
130DYRK20.45171663
131MAP3K60.45023773
132PRKCA0.44820003
133PTK20.43884399
134TRPM70.43692094
135IKBKE0.43667460
136WNK10.43163611
137CSNK1G10.42758665
138IRAK40.41463703
139PTK2B0.41224662
140CSNK1G30.41124980
141ABL10.41067231
142RPS6KB10.40668136
143TBK10.40514304
144SIK20.40506204
145MAP2K20.39103298
146GRK50.39050317
147CAMK2B0.38676068
148MAP2K60.37872376
149LMTK20.37643402
150DYRK1B0.37610221
151CDK90.37059765
152PRKAA10.36176982
153STK380.35828079
154PKN10.35274647
155ZAK0.35181636
156PRKG10.34950121
157IGF1R0.33995470

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.68661401
2Caffeine metabolism_Homo sapiens_hsa002323.87964197
3Protein export_Homo sapiens_hsa030603.67597844
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.26056410
5Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.08017951
6Chemical carcinogenesis_Homo sapiens_hsa052042.81036729
7Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.77073163
8Primary bile acid biosynthesis_Homo sapiens_hsa001202.76401315
9Retinol metabolism_Homo sapiens_hsa008302.63191448
10Sulfur metabolism_Homo sapiens_hsa009202.60528409
11Steroid hormone biosynthesis_Homo sapiens_hsa001402.55903056
12Insulin secretion_Homo sapiens_hsa049112.43988754
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.34502528
14Linoleic acid metabolism_Homo sapiens_hsa005912.24259274
15Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.13826890
16Phenylalanine metabolism_Homo sapiens_hsa003601.94277263
17Tyrosine metabolism_Homo sapiens_hsa003501.83179495
18Fatty acid degradation_Homo sapiens_hsa000711.82274369
19Vibrio cholerae infection_Homo sapiens_hsa051101.77789398
20Pancreatic secretion_Homo sapiens_hsa049721.73261512
21beta-Alanine metabolism_Homo sapiens_hsa004101.72571006
22Complement and coagulation cascades_Homo sapiens_hsa046101.71913149
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.58404812
24Synaptic vesicle cycle_Homo sapiens_hsa047211.56932111
25Type II diabetes mellitus_Homo sapiens_hsa049301.56884242
26Cocaine addiction_Homo sapiens_hsa050301.56236508
27N-Glycan biosynthesis_Homo sapiens_hsa005101.56097212
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.54761518
29Other glycan degradation_Homo sapiens_hsa005111.51373116
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.49511578
31Glycosaminoglycan degradation_Homo sapiens_hsa005311.47517378
32Drug metabolism - other enzymes_Homo sapiens_hsa009831.43504497
33Peroxisome_Homo sapiens_hsa041461.43018203
34SNARE interactions in vesicular transport_Homo sapiens_hsa041301.41402868
35Lysosome_Homo sapiens_hsa041421.40983615
36Amphetamine addiction_Homo sapiens_hsa050311.40433768
37Carbohydrate digestion and absorption_Homo sapiens_hsa049731.35936517
38Bile secretion_Homo sapiens_hsa049761.35628776
39Circadian entrainment_Homo sapiens_hsa047131.33972807
40Aldosterone synthesis and secretion_Homo sapiens_hsa049251.32405755
41Long-term potentiation_Homo sapiens_hsa047201.28020294
42Circadian rhythm_Homo sapiens_hsa047101.21919371
43GABAergic synapse_Homo sapiens_hsa047271.19058143
44Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.18008365
45Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.16764834
46Cholinergic synapse_Homo sapiens_hsa047251.16487520
47Dopaminergic synapse_Homo sapiens_hsa047281.15985658
48Propanoate metabolism_Homo sapiens_hsa006401.15558425
49Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.12062207
50Taste transduction_Homo sapiens_hsa047421.11415619
51Arachidonic acid metabolism_Homo sapiens_hsa005901.10969496
52Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.10171646
53PPAR signaling pathway_Homo sapiens_hsa033201.09531343
54Morphine addiction_Homo sapiens_hsa050321.08848528
55Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.05897243
56Regulation of autophagy_Homo sapiens_hsa041401.05126235
57Type I diabetes mellitus_Homo sapiens_hsa049401.04257874
58Arginine biosynthesis_Homo sapiens_hsa002201.03603338
59Olfactory transduction_Homo sapiens_hsa047401.02482625
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.98751923
61Thyroid hormone synthesis_Homo sapiens_hsa049180.98519350
62Collecting duct acid secretion_Homo sapiens_hsa049660.98478933
63Prolactin signaling pathway_Homo sapiens_hsa049170.98137671
64Mineral absorption_Homo sapiens_hsa049780.98039044
65Staphylococcus aureus infection_Homo sapiens_hsa051500.97891775
66Glutamatergic synapse_Homo sapiens_hsa047240.96405693
67Intestinal immune network for IgA production_Homo sapiens_hsa046720.94853288
68Serotonergic synapse_Homo sapiens_hsa047260.91787871
69Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.91513114
70Salivary secretion_Homo sapiens_hsa049700.85725056
71Vascular smooth muscle contraction_Homo sapiens_hsa042700.84717000
72Cyanoamino acid metabolism_Homo sapiens_hsa004600.84324483
73Ovarian steroidogenesis_Homo sapiens_hsa049130.82026500
74Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.81982648
75Asthma_Homo sapiens_hsa053100.81425073
76Ether lipid metabolism_Homo sapiens_hsa005650.81016013
77Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.80673962
78Phosphatidylinositol signaling system_Homo sapiens_hsa040700.80230344
79cAMP signaling pathway_Homo sapiens_hsa040240.79107549
80Gastric acid secretion_Homo sapiens_hsa049710.78422437
81Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.78263359
82Glycerolipid metabolism_Homo sapiens_hsa005610.77203140
83Renin secretion_Homo sapiens_hsa049240.76469173
84GnRH signaling pathway_Homo sapiens_hsa049120.75796701
85ABC transporters_Homo sapiens_hsa020100.72763743
86Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72224432
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.70767497
88Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.70076947
89Phototransduction_Homo sapiens_hsa047440.69760995
90Insulin resistance_Homo sapiens_hsa049310.69654296
91Estrogen signaling pathway_Homo sapiens_hsa049150.69565616
92Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.69251950
93Nicotine addiction_Homo sapiens_hsa050330.68816904
94B cell receptor signaling pathway_Homo sapiens_hsa046620.68638043
95cGMP-PKG signaling pathway_Homo sapiens_hsa040220.67163563
96Tryptophan metabolism_Homo sapiens_hsa003800.64867822
97Glucagon signaling pathway_Homo sapiens_hsa049220.64052136
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62863523
99Long-term depression_Homo sapiens_hsa047300.62632888
100Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.61878090
101Starch and sucrose metabolism_Homo sapiens_hsa005000.61606279
102Nitrogen metabolism_Homo sapiens_hsa009100.60990739
103Arginine and proline metabolism_Homo sapiens_hsa003300.60004861
104Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.57053678
105Neurotrophin signaling pathway_Homo sapiens_hsa047220.56408825
106Oxytocin signaling pathway_Homo sapiens_hsa049210.56150368
107Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.55245833
108Protein digestion and absorption_Homo sapiens_hsa049740.54413759
109Fatty acid metabolism_Homo sapiens_hsa012120.54135592
110Butanoate metabolism_Homo sapiens_hsa006500.53777829
111Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53162247
112Sphingolipid metabolism_Homo sapiens_hsa006000.52831883
113Inositol phosphate metabolism_Homo sapiens_hsa005620.51661112
114Dorso-ventral axis formation_Homo sapiens_hsa043200.51288357
115Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51049434
116Calcium signaling pathway_Homo sapiens_hsa040200.50604164
117Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.50566280
118Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.50094430
119Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.48499611
120Pancreatic cancer_Homo sapiens_hsa052120.47788325
121Insulin signaling pathway_Homo sapiens_hsa049100.45248266
122Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.44126473
123Histidine metabolism_Homo sapiens_hsa003400.44012004
124Choline metabolism in cancer_Homo sapiens_hsa052310.43871493
125Prion diseases_Homo sapiens_hsa050200.43552833
126alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.42695598
127Glioma_Homo sapiens_hsa052140.42587839
128Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.42412116
129Autoimmune thyroid disease_Homo sapiens_hsa053200.41562964
130Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40612194
131ErbB signaling pathway_Homo sapiens_hsa040120.40544750
132Fatty acid biosynthesis_Homo sapiens_hsa000610.39657192
133Folate biosynthesis_Homo sapiens_hsa007900.39455662
134Vitamin B6 metabolism_Homo sapiens_hsa007500.39439277
135Vitamin digestion and absorption_Homo sapiens_hsa049770.39201604
136Graft-versus-host disease_Homo sapiens_hsa053320.38543033
137Endometrial cancer_Homo sapiens_hsa052130.38425733
138Selenocompound metabolism_Homo sapiens_hsa004500.38259975
139Allograft rejection_Homo sapiens_hsa053300.36380242
140Chemokine signaling pathway_Homo sapiens_hsa040620.35423443
141Metabolic pathways_Homo sapiens_hsa011000.35151172
142Non-small cell lung cancer_Homo sapiens_hsa052230.35049314
143Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.34560355
144Phospholipase D signaling pathway_Homo sapiens_hsa040720.33066950
145Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.31766742
146Steroid biosynthesis_Homo sapiens_hsa001000.30878909
147Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30478672
148Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.30472321
149Fat digestion and absorption_Homo sapiens_hsa049750.30462731
150Ras signaling pathway_Homo sapiens_hsa040140.30417770
151Galactose metabolism_Homo sapiens_hsa000520.29582078
152Phagosome_Homo sapiens_hsa041450.29281596
153Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.28394019
154Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.27025318

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