SMIM19

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.83190786
2L-phenylalanine catabolic process (GO:0006559)4.83190786
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.80998114
4L-phenylalanine metabolic process (GO:0006558)4.80998114
5axonemal dynein complex assembly (GO:0070286)4.60222978
6mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.58874802
7ribosomal small subunit assembly (GO:0000028)4.57242059
8protein complex biogenesis (GO:0070271)4.49405319
9mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.49209086
10energy coupled proton transport, down electrochemical gradient (GO:0015985)4.47605813
11ATP synthesis coupled proton transport (GO:0015986)4.47605813
12establishment of protein localization to mitochondrial membrane (GO:0090151)4.44043439
13respiratory electron transport chain (GO:0022904)4.35897071
14electron transport chain (GO:0022900)4.26500794
15mitochondrial respiratory chain complex assembly (GO:0033108)4.15254653
16epithelial cilium movement (GO:0003351)4.12288621
17mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.08491462
18mitochondrial respiratory chain complex I assembly (GO:0032981)4.08491462
19NADH dehydrogenase complex assembly (GO:0010257)4.08491462
20cilium or flagellum-dependent cell motility (GO:0001539)4.07406042
21respiratory chain complex IV assembly (GO:0008535)3.95757882
22cilium movement (GO:0003341)3.90065415
23chaperone-mediated protein transport (GO:0072321)3.89679396
24pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.84113251
25axoneme assembly (GO:0035082)3.81838816
26cytochrome complex assembly (GO:0017004)3.81170302
27short-chain fatty acid metabolic process (GO:0046459)3.80322186
28DNA deamination (GO:0045006)3.75576174
29cellular ketone body metabolic process (GO:0046950)3.67235567
30succinate metabolic process (GO:0006105)3.66282550
31epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.60187886
32aromatic amino acid family catabolic process (GO:0009074)3.59273777
33protein neddylation (GO:0045116)3.59119730
34lysine catabolic process (GO:0006554)3.58388934
35lysine metabolic process (GO:0006553)3.58388934
36fatty acid beta-oxidation (GO:0006635)3.58243195
37viral transcription (GO:0019083)3.51279447
38platelet dense granule organization (GO:0060155)3.50755251
39proteasome assembly (GO:0043248)3.49887060
40glyoxylate metabolic process (GO:0046487)3.46860714
41fatty acid catabolic process (GO:0009062)3.46706527
42branched-chain amino acid catabolic process (GO:0009083)3.46073482
43translational termination (GO:0006415)3.42708128
44preassembly of GPI anchor in ER membrane (GO:0016254)3.41108556
45triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.40580698
46intraciliary transport (GO:0042073)3.40483511
47fatty acid oxidation (GO:0019395)3.40226682
48lipid oxidation (GO:0034440)3.36324662
49regulation of mitochondrial translation (GO:0070129)3.32898429
50aspartate family amino acid catabolic process (GO:0009068)3.28724795
51branched-chain amino acid metabolic process (GO:0009081)3.28568987
52GPI anchor biosynthetic process (GO:0006506)3.28394549
53monocarboxylic acid catabolic process (GO:0072329)3.27582182
54water-soluble vitamin biosynthetic process (GO:0042364)3.27279947
55SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.25199580
56cotranslational protein targeting to membrane (GO:0006613)3.24130295
57pyrimidine nucleotide catabolic process (GO:0006244)3.22964584
58GPI anchor metabolic process (GO:0006505)3.22591955
59nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.21464550
60protein targeting to ER (GO:0045047)3.20360664
61exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.19989217
62coenzyme catabolic process (GO:0009109)3.19928390
632-oxoglutarate metabolic process (GO:0006103)3.18061388
64ubiquinone biosynthetic process (GO:0006744)3.18024148
65alpha-linolenic acid metabolic process (GO:0036109)3.17941849
66ketone body metabolic process (GO:1902224)3.17169948
67tricarboxylic acid cycle (GO:0006099)3.16743159
68maturation of SSU-rRNA (GO:0030490)3.16568891
69acetyl-CoA metabolic process (GO:0006084)3.12110751
70protein localization to endoplasmic reticulum (GO:0070972)3.11915417
71RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.09681901
72tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.09681901
73valine metabolic process (GO:0006573)3.08230197
74translational elongation (GO:0006414)3.07672669
75establishment of protein localization to endoplasmic reticulum (GO:0072599)3.06103673
76protein polyglutamylation (GO:0018095)3.05645423
77regulation of oxidative phosphorylation (GO:0002082)3.05106645
78hydrogen ion transmembrane transport (GO:1902600)3.03342072
79chromatin remodeling at centromere (GO:0031055)3.02485614
80inner mitochondrial membrane organization (GO:0007007)3.01113201
81fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.01024353
82creatine metabolic process (GO:0006600)3.00201638
83biotin metabolic process (GO:0006768)3.00098515
84fatty acid transmembrane transport (GO:1902001)2.98002319
85GTP biosynthetic process (GO:0006183)2.96114864
86regulation of cilium movement (GO:0003352)2.95812261
87bile acid biosynthetic process (GO:0006699)2.95287108
88carnitine shuttle (GO:0006853)2.94572263
89amino-acid betaine metabolic process (GO:0006577)2.94190898
90protein-cofactor linkage (GO:0018065)2.93864410
91base-excision repair, AP site formation (GO:0006285)2.92064573
92ATP biosynthetic process (GO:0006754)2.91883845
93ubiquinone metabolic process (GO:0006743)2.90286676
94proton transport (GO:0015992)2.89806689
95sulfur amino acid catabolic process (GO:0000098)2.89381446
96transcription elongation from RNA polymerase III promoter (GO:0006385)2.85722587
97termination of RNA polymerase III transcription (GO:0006386)2.85722587
98hydrogen transport (GO:0006818)2.85488735
99mannosylation (GO:0097502)2.85387697
100replication fork processing (GO:0031297)2.85296190
101iron-sulfur cluster assembly (GO:0016226)2.85023937
102metallo-sulfur cluster assembly (GO:0031163)2.85023937
103positive regulation of fatty acid oxidation (GO:0046321)2.85010947
104centriole replication (GO:0007099)2.84922641
105CENP-A containing nucleosome assembly (GO:0034080)2.84044632
106cysteine metabolic process (GO:0006534)2.83231530
107carnitine metabolic process (GO:0009437)2.82730512
108carboxylic acid catabolic process (GO:0046395)2.80126515
109organic acid catabolic process (GO:0016054)2.80126515
110positive regulation of prostaglandin secretion (GO:0032308)2.78483473
111deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.78164657
112DNA double-strand break processing (GO:0000729)2.76894325
113behavioral response to nicotine (GO:0035095)2.76289784
114tricarboxylic acid metabolic process (GO:0072350)2.75710477
115quinone biosynthetic process (GO:1901663)2.75372801
116thioester biosynthetic process (GO:0035384)2.74386259
117acyl-CoA biosynthetic process (GO:0071616)2.74386259
118acyl-CoA metabolic process (GO:0006637)2.73912521
119thioester metabolic process (GO:0035383)2.73912521
120oxidative phosphorylation (GO:0006119)2.73084439
121intracellular protein transmembrane import (GO:0044743)2.72466564
122cellular amino acid catabolic process (GO:0009063)2.72392286
123pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.71623943
124oxaloacetate metabolic process (GO:0006107)2.71392211
125glutamate metabolic process (GO:0006536)2.71314606
126alpha-amino acid catabolic process (GO:1901606)2.70204043
127NADH metabolic process (GO:0006734)2.70094739
128C-terminal protein lipidation (GO:0006501)2.69750196
129aromatic amino acid family metabolic process (GO:0009072)2.69510784
130drug transmembrane transport (GO:0006855)2.67423561
131kynurenine metabolic process (GO:0070189)2.66858822
132ribosomal small subunit biogenesis (GO:0042274)2.66097917
133ribonucleoside triphosphate biosynthetic process (GO:0009201)2.65448720
134regulation of fatty acid oxidation (GO:0046320)2.62294140
135regulation of triglyceride catabolic process (GO:0010896)2.62275483
136purine nucleoside triphosphate biosynthetic process (GO:0009145)2.62115516
137very long-chain fatty acid metabolic process (GO:0000038)2.61384537
138purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.60833699
139deoxyribonucleotide catabolic process (GO:0009264)2.59608190
140regulation of acyl-CoA biosynthetic process (GO:0050812)2.58791503
141dicarboxylic acid catabolic process (GO:0043649)2.58695112
142translation (GO:0006412)2.58683811
143regulation of sequestering of triglyceride (GO:0010889)2.58574100
144viral life cycle (GO:0019058)2.58343482
145organelle disassembly (GO:1903008)2.57761954
146translational initiation (GO:0006413)2.56224465
147anterograde synaptic vesicle transport (GO:0048490)2.54386013
148regulation of hexokinase activity (GO:1903299)2.53978632
149regulation of glucokinase activity (GO:0033131)2.53978632
150positive regulation of protein homodimerization activity (GO:0090073)2.53942175
151C-terminal protein amino acid modification (GO:0018410)2.53754933
152cilium organization (GO:0044782)2.52505383
153tyrosine metabolic process (GO:0006570)2.52340743
154cellular protein complex disassembly (GO:0043624)2.51938916
155negative regulation of telomere maintenance (GO:0032205)2.51168080
156nucleoside triphosphate biosynthetic process (GO:0009142)2.50092252
157seminiferous tubule development (GO:0072520)2.49639773
158indole-containing compound catabolic process (GO:0042436)2.49504446
159indolalkylamine catabolic process (GO:0046218)2.49504446
160tryptophan catabolic process (GO:0006569)2.49504446
161opsonization (GO:0008228)2.48293234
162regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.48184374
163cellular modified amino acid catabolic process (GO:0042219)2.47951296
164flavonoid metabolic process (GO:0009812)2.47803357
165tryptophan metabolic process (GO:0006568)2.47789745
166fatty-acyl-CoA metabolic process (GO:0035337)2.46879417
167high-density lipoprotein particle remodeling (GO:0034375)2.44567449
168sarcoplasmic reticulum calcium ion transport (GO:0070296)2.44294891
169regulation of cholesterol esterification (GO:0010872)2.44097731
170disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.41871904
171killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.41871904
172response to mercury ion (GO:0046689)2.41016107
173cofactor catabolic process (GO:0051187)2.40797977
174regulation of cholesterol metabolic process (GO:0090181)2.39692928
175ethanol oxidation (GO:0006069)2.39487168
176small molecule catabolic process (GO:0044282)2.39424334
177positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.39120796
178regulation of fibrinolysis (GO:0051917)2.38983079
179regulation of cofactor metabolic process (GO:0051193)2.38956364
180regulation of coenzyme metabolic process (GO:0051196)2.38956364
181bile acid metabolic process (GO:0008206)2.36948162
182negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.36639597
183amino-acid betaine transport (GO:0015838)2.36572275
184carnitine transport (GO:0015879)2.36572275
185aldehyde catabolic process (GO:0046185)2.36532676
186coenzyme A metabolic process (GO:0015936)2.36494947

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.82210582
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.57157520
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.95813035
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.87748183
5RXR_22158963_ChIP-Seq_LIVER_Mouse3.86764068
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.49578650
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.15502675
8PPARA_22158963_ChIP-Seq_LIVER_Mouse3.07918083
9LXR_22158963_ChIP-Seq_LIVER_Mouse2.99613342
10ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.82792376
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.75423921
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.71147978
13EZH2_22144423_ChIP-Seq_EOC_Human2.55185211
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.50728481
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.45912847
16VDR_23849224_ChIP-Seq_CD4+_Human2.43650014
17FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.40326329
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.31157193
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.28392953
20SRF_21415370_ChIP-Seq_HL-1_Mouse2.23919296
21ELK1_19687146_ChIP-ChIP_HELA_Human2.10975217
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.09068147
23CREB1_15753290_ChIP-ChIP_HEK293T_Human2.05242836
24IRF1_19129219_ChIP-ChIP_H3396_Human2.01774404
25CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.01586130
26FOXP3_21729870_ChIP-Seq_TREG_Human1.98993179
27EGR1_23403033_ChIP-Seq_LIVER_Mouse1.97428629
28MYC_18940864_ChIP-ChIP_HL60_Human1.96987546
29FUS_26573619_Chip-Seq_HEK293_Human1.93707044
30NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.88333837
31NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.78272923
32EWS_26573619_Chip-Seq_HEK293_Human1.74987950
33EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.69637440
34SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.68652623
35TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.67948314
36MTF2_20144788_ChIP-Seq_MESCs_Mouse1.67306596
37SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.65346662
38GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.63482585
39AR_21572438_ChIP-Seq_LNCaP_Human1.63035238
40FLI1_27457419_Chip-Seq_LIVER_Mouse1.63003225
41MYC_18555785_ChIP-Seq_MESCs_Mouse1.62023601
42POU3F2_20337985_ChIP-ChIP_501MEL_Human1.61039294
43TP53_22573176_ChIP-Seq_HFKS_Human1.57451419
44SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.57227479
45SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.56401201
46SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.54973674
47TAF15_26573619_Chip-Seq_HEK293_Human1.54284285
48CLOCK_20551151_ChIP-Seq_293T_Human1.49911118
49GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.49000184
50FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.47670504
51ZFP57_27257070_Chip-Seq_ESCs_Mouse1.44644486
52CDX2_19796622_ChIP-Seq_MESCs_Mouse1.42207504
53FOXA1_25329375_ChIP-Seq_VCAP_Human1.40453652
54FOXA1_27270436_Chip-Seq_PROSTATE_Human1.40453652
55JARID2_20064375_ChIP-Seq_MESCs_Mouse1.40068452
56TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38781949
57NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.38697437
58NRF2_20460467_ChIP-Seq_MEFs_Mouse1.38697437
59EP300_21415370_ChIP-Seq_HL-1_Mouse1.38573073
60SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.36815024
61GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.36632905
62AR_20517297_ChIP-Seq_VCAP_Human1.36463117
63MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.35869657
64TTF2_22483619_ChIP-Seq_HELA_Human1.35452797
65VDR_22108803_ChIP-Seq_LS180_Human1.34780793
66GABP_19822575_ChIP-Seq_HepG2_Human1.31746100
67JARID2_20075857_ChIP-Seq_MESCs_Mouse1.29149840
68EZH2_27294783_Chip-Seq_ESCs_Mouse1.28949713
69POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.27989205
70BP1_19119308_ChIP-ChIP_Hs578T_Human1.26364554
71SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.25858552
72MYC_18358816_ChIP-ChIP_MESCs_Mouse1.25351171
73ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.25242817
74ZNF263_19887448_ChIP-Seq_K562_Human1.25035328
75PCGF2_27294783_Chip-Seq_ESCs_Mouse1.24860263
76LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.24794276
77RNF2_18974828_ChIP-Seq_MESCs_Mouse1.23874286
78EZH2_18974828_ChIP-Seq_MESCs_Mouse1.23874286
79E2F4_17652178_ChIP-ChIP_JURKAT_Human1.23686381
80PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21319950
81E2F1_18555785_ChIP-Seq_MESCs_Mouse1.20695178
82SUZ12_27294783_Chip-Seq_ESCs_Mouse1.19582513
83CTBP1_25329375_ChIP-Seq_LNCAP_Human1.18290635
84CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.17972902
85IGF1R_20145208_ChIP-Seq_DFB_Human1.17007263
86NCOR_22424771_ChIP-Seq_293T_Human1.16835495
87FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.16700337
88HOXB4_20404135_ChIP-ChIP_EML_Mouse1.15186222
89BCAT_22108803_ChIP-Seq_LS180_Human1.12641227
90PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.12585026
91TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.11540805
92THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.11266993
93FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10220184
94PADI4_21655091_ChIP-ChIP_MCF-7_Human1.09169239
95SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08479466
96NR3C1_23031785_ChIP-Seq_PC12_Mouse1.08426454
97RARG_19884340_ChIP-ChIP_MEFs_Mouse1.06780038
98CTBP2_25329375_ChIP-Seq_LNCAP_Human1.06771251
99THAP11_20581084_ChIP-Seq_MESCs_Mouse1.06392964
100POU5F1_16153702_ChIP-ChIP_HESCs_Human1.05903348
101SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03314418
102GATA3_21878914_ChIP-Seq_MCF-7_Human1.03084858
103CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.02380522
104ERG_20517297_ChIP-Seq_VCAP_Human1.02375188
105TBX20_22328084_ChIP-Seq_HEART_Mouse1.00824355
106TBX20_22080862_ChIP-Seq_HEART_Mouse1.00824355
107ER_23166858_ChIP-Seq_MCF-7_Human0.98732513
108ZNF274_21170338_ChIP-Seq_K562_Hela0.97614288
109HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.97458625
110PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.96580211
111PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.95654687
112EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.95634575
113REST_18959480_ChIP-ChIP_MESCs_Mouse0.95619260
114EGR1_19032775_ChIP-ChIP_M12_Human0.95481798
115DCP1A_22483619_ChIP-Seq_HELA_Human0.95160254
116NANOG_20526341_ChIP-Seq_ESCs_Human0.94693813
117CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.94645370
118PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.93566466
119ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.93518379
120ESR1_20079471_ChIP-ChIP_T-47D_Human0.93444910
121SOX2_16153702_ChIP-ChIP_HESCs_Human0.92924964
122BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.92509187
123ETV2_25802403_ChIP-Seq_MESCs_Mouse0.92323419
124YY1_21170310_ChIP-Seq_MESCs_Mouse0.91604887
125AUTS2_25519132_ChIP-Seq_293T-REX_Human0.91277425
126EED_16625203_ChIP-ChIP_MESCs_Mouse0.91072035
127MYC_19030024_ChIP-ChIP_MESCs_Mouse0.90740921
128FOXH1_21741376_ChIP-Seq_EPCs_Human0.90240273
129EZH2_27304074_Chip-Seq_ESCs_Mouse0.89894592
130BMI1_23680149_ChIP-Seq_NPCS_Mouse0.89279909
131DNAJC2_21179169_ChIP-ChIP_NT2_Human0.87821821
132PIAS1_25552417_ChIP-Seq_VCAP_Human0.87790669
133PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.87375880
134KLF5_20875108_ChIP-Seq_MESCs_Mouse0.87340558
135ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.86806858
136NFE2_27457419_Chip-Seq_LIVER_Mouse0.86668649
137GATA1_22025678_ChIP-Seq_K562_Human0.86317309
138CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.86164318
139REST_21632747_ChIP-Seq_MESCs_Mouse0.85669183
140NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.84330849
141EZH2_27294783_Chip-Seq_NPCs_Mouse0.83713334
142HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.83417940
143RBPJ_21746931_ChIP-Seq_IB4_Human0.82873171
144PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.82233460
145NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.81506828
146TOP2B_26459242_ChIP-Seq_MCF-7_Human0.80744778
147HTT_18923047_ChIP-ChIP_STHdh_Human0.80668484
148P300_19829295_ChIP-Seq_ESCs_Human0.80526385
149SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.78290542
150MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.78107565
151IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.78088910
152CBP_20019798_ChIP-Seq_JUKART_Human0.78088910
153RARB_27405468_Chip-Seq_BRAIN_Mouse0.77175460
154AR_25329375_ChIP-Seq_VCAP_Human0.77074773
155E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.75738021
156RAD21_21589869_ChIP-Seq_MESCs_Mouse0.74106617
157SMC3_22415368_ChIP-Seq_MEFs_Mouse0.73902787
158FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.73466034
159GBX2_23144817_ChIP-Seq_PC3_Human0.72839314
160SOX2_20726797_ChIP-Seq_SW620_Human0.71916228
161ERG_21242973_ChIP-ChIP_JURKAT_Human0.71640103
162PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.71334998
163RNF2_27304074_Chip-Seq_ESCs_Mouse0.70729998
164EOMES_21245162_ChIP-Seq_HESCs_Human0.70612645
165WT1_19549856_ChIP-ChIP_CCG9911_Human0.69605758
166PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.69253442
167PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.69251298
168SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.68739684
169FOXH1_21741376_ChIP-Seq_ESCs_Human0.68683706
170AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.68673254
171NANOG_19829295_ChIP-Seq_ESCs_Human0.68343383
172SOX2_19829295_ChIP-Seq_ESCs_Human0.68343383
173FOXA2_19822575_ChIP-Seq_HepG2_Human0.68085908
174UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.67469890

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.41205218
2MP0002837_dystrophic_cardiac_calcinosis4.09771564
3MP0005360_urolithiasis3.57274594
4MP0006292_abnormal_olfactory_placode3.19608402
5MP0005365_abnormal_bile_salt2.99293651
6MP0005085_abnormal_gallbladder_physiolo2.95884043
7MP0003195_calcinosis2.69816470
8MP0000751_myopathy2.68853283
9MP0003646_muscle_fatigue2.67491500
10MP0008877_abnormal_DNA_methylation2.62869475
11MP0002653_abnormal_ependyma_morphology2.62787940
12MP0005083_abnormal_biliary_tract2.61068530
13MP0008875_abnormal_xenobiotic_pharmacok2.55071431
14MP0000372_irregular_coat_pigmentation2.45419325
15MP0004130_abnormal_muscle_cell2.42290153
16MP0003787_abnormal_imprinting2.37604596
17MP0005332_abnormal_amino_acid2.33207191
18MP0004147_increased_porphyrin_level2.26386332
19MP0006036_abnormal_mitochondrial_physio2.21419648
20MP0008058_abnormal_DNA_repair2.17049098
21MP0003329_amyloid_beta_deposits2.10134644
22MP0006072_abnormal_retinal_apoptosis2.06433442
23MP0004036_abnormal_muscle_relaxation2.01408731
24MP0009840_abnormal_foam_cell1.96635247
25MP0008789_abnormal_olfactory_epithelium1.94734346
26MP0000749_muscle_degeneration1.88344545
27MP0003011_delayed_dark_adaptation1.88332165
28MP0010329_abnormal_lipoprotein_level1.87898830
29MP0002102_abnormal_ear_morphology1.80686697
30MP0003806_abnormal_nucleotide_metabolis1.80297734
31MP0001984_abnormal_olfaction1.79639151
32MP0005330_cardiomyopathy1.78231869
33MP0000747_muscle_weakness1.77619325
34MP0005645_abnormal_hypothalamus_physiol1.77423935
35MP0004215_abnormal_myocardial_fiber1.76286774
36MP0004043_abnormal_pH_regulation1.73521148
37MP0005075_abnormal_melanosome_morpholog1.71835195
38MP0004145_abnormal_muscle_electrophysio1.69737666
39MP0005551_abnormal_eye_electrophysiolog1.69705139
40MP0003718_maternal_effect1.65703928
41MP0002118_abnormal_lipid_homeostasis1.63546113
42MP0005584_abnormal_enzyme/coenzyme_acti1.59884197
43MP0004084_abnormal_cardiac_muscle1.59521916
44MP0001666_abnormal_nutrient_absorption1.58099159
45MP0004133_heterotaxia1.56737947
46MP0005535_abnormal_body_temperature1.56586085
47MP0002938_white_spotting1.56165182
48MP0002735_abnormal_chemical_nociception1.55601179
49MP0008872_abnormal_physiological_respon1.52591925
50MP0001968_abnormal_touch/_nociception1.48012896
51MP0000604_amyloidosis1.43016060
52MP0002638_abnormal_pupillary_reflex1.42741095
53MP0002736_abnormal_nociception_after1.42106324
54MP0005253_abnormal_eye_physiology1.41506036
55MP0002160_abnormal_reproductive_system1.41369724
56MP0001485_abnormal_pinna_reflex1.40486166
57MP0000013_abnormal_adipose_tissue1.38432779
58MP0003121_genomic_imprinting1.37778002
59MP0006276_abnormal_autonomic_nervous1.37664470
60MP0002971_abnormal_brown_adipose1.37155213
61MP0005620_abnormal_muscle_contractility1.36121068
62MP0001293_anophthalmia1.35601191
63MP0002909_abnormal_adrenal_gland1.35283678
64MP0008995_early_reproductive_senescence1.32744260
65MP0001986_abnormal_taste_sensitivity1.32383978
66MP0003880_abnormal_central_pattern1.31686240
67MP0005394_taste/olfaction_phenotype1.31136073
68MP0005499_abnormal_olfactory_system1.31136073
69MP0003690_abnormal_glial_cell1.29676753
70MP0002078_abnormal_glucose_homeostasis1.28230206
71MP0005389_reproductive_system_phenotype1.28206514
72MP0000631_abnormal_neuroendocrine_gland1.27721521
73MP0003122_maternal_imprinting1.23895131
74MP0002972_abnormal_cardiac_muscle1.23425470
75MP0009697_abnormal_copulation1.23052195
76MP0005319_abnormal_enzyme/_coenzyme1.21413682
77MP0003137_abnormal_impulse_conducting1.20110370
78MP0000609_abnormal_liver_physiology1.16530353
79MP0004484_altered_response_of1.15893004
80MP0004087_abnormal_muscle_fiber1.15393567
81MP0003786_premature_aging1.15339922
82MP0009780_abnormal_chondrocyte_physiolo1.15023270
83MP0002106_abnormal_muscle_physiology1.14559035
84MP0009379_abnormal_foot_pigmentation1.12868357
85MP0002064_seizures1.11987470
86MP0009643_abnormal_urine_homeostasis1.11935687
87MP0002269_muscular_atrophy1.11656786
88MP0003191_abnormal_cellular_cholesterol1.10976985
89MP0002277_abnormal_respiratory_mucosa1.10560527
90MP0003635_abnormal_synaptic_transmissio1.10191108
91MP0000230_abnormal_systemic_arterial1.08328096
92MP0003252_abnormal_bile_duct1.07191093
93MP0002272_abnormal_nervous_system1.05477385
94MP0002138_abnormal_hepatobiliary_system1.04924405
95MP0000920_abnormal_myelination1.04828005
96MP0000759_abnormal_skeletal_muscle1.04759021
97MP0002876_abnormal_thyroid_physiology1.01919299
98MP0006035_abnormal_mitochondrial_morpho1.01444108
99MP0004270_analgesia1.00663221
100MP0001501_abnormal_sleep_pattern1.00655253
101MP0005636_abnormal_mineral_homeostasis0.99625163
102MP0005666_abnormal_adipose_tissue0.99003110
103MP0002557_abnormal_social/conspecific_i0.98723783
104MP0009745_abnormal_behavioral_response0.98548175
105MP0005369_muscle_phenotype0.98008244
106MP0002332_abnormal_exercise_endurance0.97134652
107MP0001544_abnormal_cardiovascular_syste0.96257196
108MP0005385_cardiovascular_system_phenoty0.96257196
109MP0004859_abnormal_synaptic_plasticity0.96122086
110MP0002234_abnormal_pharynx_morphology0.95358294
111MP0001440_abnormal_grooming_behavior0.94810736
112MP0003959_abnormal_lean_body0.94544107
113MP0003136_yellow_coat_color0.93913732
114MP0002734_abnormal_mechanical_nocicepti0.93775695
115MP0005084_abnormal_gallbladder_morpholo0.93579376
116MP0003075_altered_response_to0.93194341
117MP0000750_abnormal_muscle_regeneration0.93143097
118MP0005646_abnormal_pituitary_gland0.92922492
119MP0004019_abnormal_vitamin_homeostasis0.90149641
120MP0008874_decreased_physiological_sensi0.90149092
121MP0001905_abnormal_dopamine_level0.90062812
122MP0001929_abnormal_gametogenesis0.90040185
123MP0004142_abnormal_muscle_tone0.90011667
124MP0004885_abnormal_endolymph0.89363515
125MP0004085_abnormal_heartbeat0.89184360
126MP0003693_abnormal_embryo_hatching0.87543273
127MP0003656_abnormal_erythrocyte_physiolo0.87489205
128MP0003698_abnormal_male_reproductive0.86562509
129MP0002095_abnormal_skin_pigmentation0.86481765
130MP0001970_abnormal_pain_threshold0.84452752
131MP0005448_abnormal_energy_balance0.83921220
132MP0002210_abnormal_sex_determination0.83633200
133MP0002733_abnormal_thermal_nociception0.83282095
134MP0004185_abnormal_adipocyte_glucose0.83146824
135MP0003868_abnormal_feces_composition0.82933422
136MP0003879_abnormal_hair_cell0.82674435
137MP0004233_abnormal_muscle_weight0.82370262
138MP0005334_abnormal_fat_pad0.81592032
139MP0000653_abnormal_sex_gland0.80859941
140MP0003633_abnormal_nervous_system0.80664670
141MP0003567_abnormal_fetal_cardiomyocyte0.79995885
142MP0002822_catalepsy0.79989011
143MP0001765_abnormal_ion_homeostasis0.79605302
144MP0005375_adipose_tissue_phenotype0.79125561
145MP0003186_abnormal_redox_activity0.78688056
146MP0001145_abnormal_male_reproductive0.78684813
147MP0009046_muscle_twitch0.77799367
148MP0010094_abnormal_chromosome_stability0.76789572
149MP0002063_abnormal_learning/memory/cond0.76585865
150MP0001486_abnormal_startle_reflex0.76343961
151MP0005379_endocrine/exocrine_gland_phen0.75445221
152MP0001764_abnormal_homeostasis0.75362139
153MP0002572_abnormal_emotion/affect_behav0.74544729
154MP0002163_abnormal_gland_morphology0.74300276
155MP0005595_abnormal_vascular_smooth0.74080116
156MP0001529_abnormal_vocalization0.73809880
157MP0008961_abnormal_basal_metabolism0.72577404
158MP0006138_congestive_heart_failure0.71307071
159MP0004924_abnormal_behavior0.71095791
160MP0001919_abnormal_reproductive_system0.70780730
161MP0005423_abnormal_somatic_nervous0.68449548
162MP0005195_abnormal_posterior_eye0.68259766
163MP0003283_abnormal_digestive_organ0.68007791
164MP0002067_abnormal_sensory_capabilities0.67185099
165MP0005266_abnormal_metabolism0.65400210
166MP0000026_abnormal_inner_ear0.65170084

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)4.53459127
2Abnormal respiratory motile cilium morphology (HP:0005938)4.09406706
3Abnormal respiratory epithelium morphology (HP:0012253)4.09406706
4Ketosis (HP:0001946)3.85614687
5Acute encephalopathy (HP:0006846)3.80516633
6Molar tooth sign on MRI (HP:0002419)3.80469867
7Abnormality of midbrain morphology (HP:0002418)3.80469867
8Absent/shortened dynein arms (HP:0200106)3.79277987
9Dynein arm defect of respiratory motile cilia (HP:0012255)3.79277987
10Hypoglycemic coma (HP:0001325)3.78467948
11Hepatic necrosis (HP:0002605)3.77028361
12Acute necrotizing encephalopathy (HP:0006965)3.75028095
13Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.74571780
14Abnormal ciliary motility (HP:0012262)3.71215221
15Abnormal mitochondria in muscle tissue (HP:0008316)3.70917943
16Pancreatic fibrosis (HP:0100732)3.66910341
17Ketoacidosis (HP:0001993)3.65937811
18Exercise-induced myalgia (HP:0003738)3.61567906
19Abnormal respiratory motile cilium physiology (HP:0012261)3.56402285
20Nephronophthisis (HP:0000090)3.54441330
21Pancreatic cysts (HP:0001737)3.51279250
22True hermaphroditism (HP:0010459)3.50542091
23Cerebral edema (HP:0002181)3.46662547
24Myoglobinuria (HP:0002913)3.45495119
25Mitochondrial inheritance (HP:0001427)3.41467004
26Hepatocellular necrosis (HP:0001404)3.40205921
27Increased muscle lipid content (HP:0009058)3.25926476
28Hyperammonemia (HP:0001987)3.21072802
29Progressive macrocephaly (HP:0004481)3.20314137
30Rhinitis (HP:0012384)3.20092430
31Xanthomatosis (HP:0000991)3.17772825
32Muscle hypertrophy of the lower extremities (HP:0008968)3.08808075
33Hyperlipoproteinemia (HP:0010980)3.06078175
34Increased CSF lactate (HP:0002490)3.05284551
35Increased intramyocellular lipid droplets (HP:0012240)3.03628334
36Medial flaring of the eyebrow (HP:0010747)3.02763679
37Abnormality of dicarboxylic acid metabolism (HP:0010995)3.00616599
38Dicarboxylic aciduria (HP:0003215)3.00616599
39Calf muscle hypertrophy (HP:0008981)2.94852972
40Pheochromocytoma (HP:0002666)2.94117996
41Abnormality of fatty-acid metabolism (HP:0004359)2.94067377
42Neuroendocrine neoplasm (HP:0100634)2.86328646
43Abnormality of glycine metabolism (HP:0010895)2.85452031
44Abnormality of serine family amino acid metabolism (HP:0010894)2.85452031
45Exercise-induced muscle cramps (HP:0003710)2.82090102
46Lipid accumulation in hepatocytes (HP:0006561)2.80228270
47Lactic acidosis (HP:0003128)2.80179179
48Hyperglycinuria (HP:0003108)2.77988923
49Hyperglycinemia (HP:0002154)2.77523041
50Generalized aminoaciduria (HP:0002909)2.75225524
51Abnormality of the renal medulla (HP:0100957)2.70265381
52Deep venous thrombosis (HP:0002625)2.68677188
53Abnormal number of erythroid precursors (HP:0012131)2.65939684
54Chronic hepatic failure (HP:0100626)2.65183996
55Intrahepatic cholestasis (HP:0001406)2.63709078
56Abnormality of cells of the erythroid lineage (HP:0012130)2.54948573
57Cerebral hemorrhage (HP:0001342)2.54838306
58Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.54800572
59Decreased activity of mitochondrial respiratory chain (HP:0008972)2.54800572
60Prolonged partial thromboplastin time (HP:0003645)2.51973895
61Increased hepatocellular lipid droplets (HP:0006565)2.50772900
62Lethargy (HP:0001254)2.49381639
63Metabolic acidosis (HP:0001942)2.48556540
64Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.44181824
65Palpitations (HP:0001962)2.41225544
66Reticulocytopenia (HP:0001896)2.40578803
67Hypoglycemic seizures (HP:0002173)2.39188845
68Abnormal biliary tract physiology (HP:0012439)2.38620811
69Bile duct proliferation (HP:0001408)2.38620811
70Respiratory failure (HP:0002878)2.38422803
71Hyperinsulinemic hypoglycemia (HP:0000825)2.38314585
72Ragged-red muscle fibers (HP:0003200)2.37709234
73Hypoalphalipoproteinemia (HP:0003233)2.36993079
74Gait imbalance (HP:0002141)2.36756443
75Congenital primary aphakia (HP:0007707)2.35827579
76Chronic bronchitis (HP:0004469)2.33064370
77Rhabdomyolysis (HP:0003201)2.31882375
78Congenital stationary night blindness (HP:0007642)2.30948155
79Exercise intolerance (HP:0003546)2.30860646
80Neurofibrillary tangles (HP:0002185)2.29241114
81Sudden death (HP:0001699)2.29097487
82Renal Fanconi syndrome (HP:0001994)2.27206999
83Glycosuria (HP:0003076)2.26849891
84Abnormality of urine glucose concentration (HP:0011016)2.26849891
85Type I transferrin isoform profile (HP:0003642)2.26799931
86Vomiting (HP:0002013)2.25912925
87Optic disc pallor (HP:0000543)2.25863984
88Cystic liver disease (HP:0006706)2.25613260
89Nephrogenic diabetes insipidus (HP:0009806)2.24685693
90Type II lissencephaly (HP:0007260)2.22713250
91Sclerocornea (HP:0000647)2.22490470
92Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.20227709
93Postaxial foot polydactyly (HP:0001830)2.18255477
94Hypobetalipoproteinemia (HP:0003563)2.18190790
95Reduced antithrombin III activity (HP:0001976)2.17601104
96Hypolipoproteinemia (HP:0010981)2.16518452
97Gout (HP:0001997)2.14586741
98Methylmalonic aciduria (HP:0012120)2.14561054
99Abolished electroretinogram (ERG) (HP:0000550)2.13279946
100Aplasia/Hypoplasia of the tongue (HP:0010295)2.13074457
101Muscle stiffness (HP:0003552)2.12042647
102Occipital encephalocele (HP:0002085)2.10882035
103Abnormality of the calf musculature (HP:0001430)2.10799218
104Myotonia (HP:0002486)2.10573524
105Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.09584905
106Bronchiectasis (HP:0002110)2.09452634
107Brushfield spots (HP:0001088)2.09003284
108Late onset (HP:0003584)2.08981397
109Colon cancer (HP:0003003)2.08970752
110Congenital hepatic fibrosis (HP:0002612)2.08252572
111Abnormality of the renal cortex (HP:0011035)2.07719187
112Anencephaly (HP:0002323)2.06879573
113Macrocytic anemia (HP:0001972)2.06846794
114EMG: myopathic abnormalities (HP:0003458)2.06079507
115Abnormal protein glycosylation (HP:0012346)2.04570310
116Abnormal glycosylation (HP:0012345)2.04570310
117Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.04570310
118Abnormal protein N-linked glycosylation (HP:0012347)2.04570310
119Chronic sinusitis (HP:0011109)2.01607998
120Failure to thrive in infancy (HP:0001531)2.01218345
121Symptomatic seizures (HP:0011145)2.01034592
122Abnormality of monocarboxylic acid metabolism (HP:0010996)2.00849843
123Recurrent sinusitis (HP:0011108)2.00083891
124Male pseudohermaphroditism (HP:0000037)1.99762767
125Abnormality of the common coagulation pathway (HP:0010990)1.99548291
1263-Methylglutaconic aciduria (HP:0003535)1.97420515
127Visual hallucinations (HP:0002367)1.97113055
128Muscle fiber splitting (HP:0003555)1.95857885
129Leukodystrophy (HP:0002415)1.95596937
130Retinal dysplasia (HP:0007973)1.95152189
131Muscle fiber inclusion bodies (HP:0100299)1.93892653
132Skin nodule (HP:0200036)1.93829198
133Hyperventilation (HP:0002883)1.93363920
134Abnormality of glutamine family amino acid metabolism (HP:0010902)1.93066596
135Cerebral inclusion bodies (HP:0100314)1.92860949
136Complement deficiency (HP:0004431)1.92699688
137Abnormality of the labia minora (HP:0012880)1.91811008
138Abnormality of glycolysis (HP:0004366)1.91732367
139Increased serum pyruvate (HP:0003542)1.91732367
140Asymmetric septal hypertrophy (HP:0001670)1.91425754
141Oligomenorrhea (HP:0000876)1.91201055
142Increased serum lactate (HP:0002151)1.91187445
143Methylmalonic acidemia (HP:0002912)1.90588239
144Hyperphosphaturia (HP:0003109)1.88003164
145Abnormality of serum amino acid levels (HP:0003112)1.87234423
146Genital tract atresia (HP:0001827)1.85277392
147Hypothermia (HP:0002045)1.85148428
148Tachypnea (HP:0002789)1.84966924
149Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.84962441
150Tubular atrophy (HP:0000092)1.84657290
151Median cleft lip (HP:0000161)1.80680193
152Vaginal atresia (HP:0000148)1.80349446
153Abnormality of macular pigmentation (HP:0008002)1.80318641
154Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.80147832
155Aplasia/Hypoplasia of the spleen (HP:0010451)1.79811836
156Abnormality of alanine metabolism (HP:0010916)1.79347923
157Hyperalaninemia (HP:0003348)1.79347923
158Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.79347923
159Asplenia (HP:0001746)1.75758624
160Exertional dyspnea (HP:0002875)1.74311608
161Abnormality of aspartate family amino acid metabolism (HP:0010899)1.73232623

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.44480918
2ZAK3.07728160
3VRK22.94599069
4STK162.67987008
5MAP4K22.62330382
6NUAK12.51566688
7TLK12.23950588
8ARAF2.16994159
9WNK32.12856831
10VRK12.12767923
11FRK2.11511903
12OBSCN2.03418764
13MAP3K121.97781531
14CAMKK21.97702264
15MAP2K41.94151965
16PHKG21.90041630
17PHKG11.90041630
18WNK41.88583909
19ACVR1B1.86050039
20PINK11.79243408
21TRIB31.77776347
22ERN11.74741561
23MST41.73200244
24ADRBK21.71031803
25TRIM281.69600755
26GRK11.68703200
27MAP3K91.67844183
28INSRR1.67622532
29PLK41.63893545
30EPHA41.63704731
31MUSK1.62834725
32NME21.60396623
33SCYL21.59529473
34MAP3K131.58758740
35MAP2K71.58020667
36EIF2AK31.48561962
37MAPK151.47935391
38TTN1.47477104
39LMTK21.46440168
40CDK191.43946182
41DYRK21.40235199
42MYLK1.36773750
43TXK1.31219827
44RIPK41.29550237
45SIK11.26566881
46LIMK11.25570874
47MAPKAPK31.24109583
48PAK31.23093191
49MAPK131.23040130
50STK391.22352301
51KSR21.21455225
52DAPK21.21029645
53TIE11.19147235
54NTRK31.18927746
55TAF11.18315745
56MAPK121.13709032
57NEK11.13381544
58CAMK2D1.12912434
59CAMK2G1.08315498
60MAP3K111.08178504
61OXSR11.08110340
62FES1.07224090
63NTRK11.06920538
64PDK31.04107633
65PDK41.04107633
66STK241.02991395
67CAMK1G1.02287128
68CASK0.97704720
69CAMK2A0.95874252
70MAP3K40.95857364
71CSNK1G30.94736786
72TAOK30.93996774
73PTK2B0.91835571
74GRK70.91818357
75MAP3K70.91619791
76PIK3CG0.91016642
77EPHB10.88768150
78MAP3K10.88726482
79CDC70.87693309
80DAPK10.86962235
81FLT30.85059353
82TNIK0.84996532
83CSNK1G10.84819223
84CAMK1D0.84467341
85BRSK20.84222625
86CCNB10.83912991
87KIT0.83816062
88PLK30.83105170
89PLK10.81799017
90DMPK0.80242267
91DYRK30.79961959
92MINK10.79426889
93BUB10.79396320
94EPHB20.79105731
95GRK50.78921932
96RPS6KA50.78739346
97PIK3CA0.77569634
98CAMK2B0.76665009
99KDR0.76606372
100CAMK10.75702730
101MKNK10.75209671
102ERBB30.74563647
103ATR0.73716523
104NTRK20.71353625
105UHMK10.71066103
106TESK20.68012387
107CSNK1A1L0.67940191
108TEC0.66440040
109NME10.66250601
110MAP2K30.66061417
111CAMKK10.65635256
112PLK20.64955003
113PIM20.64759687
114PNCK0.64226601
115MOS0.63872970
116BMPR20.63799576
117PASK0.63010291
118ABL20.62829192
119PRKCQ0.62238094
120MKNK20.61905359
121MAPKAPK50.61737985
122MATK0.59112630
123CDK50.59069872
124BCR0.58301116
125PRKG20.56643213
126ADRBK10.56590813
127MAPK40.56213123
128PRKCG0.56168371
129ROCK20.55889283
130SRPK10.55679733
131GRK60.55030123
132PDPK10.54122348
133RAF10.53467640
134PRKD10.53246297
135ILK0.53129277
136IRAK10.52858202
137PRKCE0.52159735
138TGFBR10.51724993
139PRKACA0.50500878
140FGR0.49900163
141MAPK110.49534814
142CSNK2A10.49403134
143PRKAA20.48629313
144MAP3K50.48263252
145TBK10.47654681
146BMPR1B0.47408833
147TTK0.47399323
148PRKACG0.45919623
149CSNK2A20.45171725
150MAP2K10.44794116
151RET0.43508985
152HIPK20.43398595
153LRRK20.42870917
154CSNK1G20.42403151
155DAPK30.41858100
156IKBKB0.40451813
157WEE10.39729915
158PDK20.39070494
159CHEK20.38269058
160CSNK1A10.38087992
161PRKCA0.38003652
162PRKCI0.37747136
163TNK20.36368268
164ATM0.35930581

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.17197440
2Ribosome_Homo sapiens_hsa030103.10083856
3Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.92319917
4Propanoate metabolism_Homo sapiens_hsa006402.82153699
5Parkinsons disease_Homo sapiens_hsa050122.81809344
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.70906055
7Fatty acid degradation_Homo sapiens_hsa000712.69223651
8Primary bile acid biosynthesis_Homo sapiens_hsa001202.44728697
9Proteasome_Homo sapiens_hsa030502.37551229
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.34289931
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.33260058
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.28711860
13Alzheimers disease_Homo sapiens_hsa050102.28503305
14Butanoate metabolism_Homo sapiens_hsa006502.25297896
15Fatty acid metabolism_Homo sapiens_hsa012122.20621481
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.20594416
17Fatty acid elongation_Homo sapiens_hsa000622.17206667
18Nitrogen metabolism_Homo sapiens_hsa009102.11614799
19RNA polymerase_Homo sapiens_hsa030202.05498166
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.02816862
21Homologous recombination_Homo sapiens_hsa034401.96015931
22Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.94004888
23Peroxisome_Homo sapiens_hsa041461.93530165
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.90318332
25Tryptophan metabolism_Homo sapiens_hsa003801.82240796
26Arginine biosynthesis_Homo sapiens_hsa002201.81077095
27Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.78783088
28Pyruvate metabolism_Homo sapiens_hsa006201.78479119
29Cardiac muscle contraction_Homo sapiens_hsa042601.78474975
30Sulfur metabolism_Homo sapiens_hsa009201.75856304
31Mismatch repair_Homo sapiens_hsa034301.68112700
32Fanconi anemia pathway_Homo sapiens_hsa034601.63750673
33Linoleic acid metabolism_Homo sapiens_hsa005911.61087484
34beta-Alanine metabolism_Homo sapiens_hsa004101.60730854
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.58868621
36PPAR signaling pathway_Homo sapiens_hsa033201.55110755
37Huntingtons disease_Homo sapiens_hsa050161.54608079
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.53386169
39Nucleotide excision repair_Homo sapiens_hsa034201.37921158
40Carbon metabolism_Homo sapiens_hsa012001.35976665
41Base excision repair_Homo sapiens_hsa034101.35184391
42Protein export_Homo sapiens_hsa030601.30290351
43Basal transcription factors_Homo sapiens_hsa030221.25944367
44Pentose and glucuronate interconversions_Homo sapiens_hsa000401.25559398
45alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.25427141
46Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.24647596
47DNA replication_Homo sapiens_hsa030301.24280509
48RNA degradation_Homo sapiens_hsa030181.23513997
49Phototransduction_Homo sapiens_hsa047441.19822096
50Starch and sucrose metabolism_Homo sapiens_hsa005001.17970813
51Pyrimidine metabolism_Homo sapiens_hsa002401.16277907
52Folate biosynthesis_Homo sapiens_hsa007901.12218113
53Phenylalanine metabolism_Homo sapiens_hsa003601.11363092
54Maturity onset diabetes of the young_Homo sapiens_hsa049501.09125139
55Complement and coagulation cascades_Homo sapiens_hsa046101.09105668
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.08506297
57Histidine metabolism_Homo sapiens_hsa003401.07427975
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.07021945
59Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.04378717
60Arginine and proline metabolism_Homo sapiens_hsa003301.04161842
61Selenocompound metabolism_Homo sapiens_hsa004501.03816217
62Asthma_Homo sapiens_hsa053101.03464967
63One carbon pool by folate_Homo sapiens_hsa006701.02442325
64Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.01703686
65Purine metabolism_Homo sapiens_hsa002301.01679639
66Tyrosine metabolism_Homo sapiens_hsa003500.92094762
67Bile secretion_Homo sapiens_hsa049760.91323849
68Arachidonic acid metabolism_Homo sapiens_hsa005900.91081633
69Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.90049162
70Non-homologous end-joining_Homo sapiens_hsa034500.87388091
71Regulation of autophagy_Homo sapiens_hsa041400.87346875
72Fat digestion and absorption_Homo sapiens_hsa049750.83242156
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.80421235
74Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.80385934
75Chemical carcinogenesis_Homo sapiens_hsa052040.79505429
76Intestinal immune network for IgA production_Homo sapiens_hsa046720.73198451
77Glycerolipid metabolism_Homo sapiens_hsa005610.73057127
78GABAergic synapse_Homo sapiens_hsa047270.70988472
79Retinol metabolism_Homo sapiens_hsa008300.68860462
80Biosynthesis of amino acids_Homo sapiens_hsa012300.68454228
81Ether lipid metabolism_Homo sapiens_hsa005650.68160432
82Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.67850664
83Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.67798228
84Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.66398518
85Fatty acid biosynthesis_Homo sapiens_hsa000610.64690695
86Metabolic pathways_Homo sapiens_hsa011000.63591797
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59298370
88Steroid hormone biosynthesis_Homo sapiens_hsa001400.59193386
89Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58351680
90Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.56252607
91Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.53656462
92SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53306307
93RNA transport_Homo sapiens_hsa030130.52306887
94Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.52055253
95Primary immunodeficiency_Homo sapiens_hsa053400.51272544
96Glucagon signaling pathway_Homo sapiens_hsa049220.51167883
97Spliceosome_Homo sapiens_hsa030400.50124739
98Cyanoamino acid metabolism_Homo sapiens_hsa004600.49930345
99Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.48598091
100Type I diabetes mellitus_Homo sapiens_hsa049400.48233587
101Vibrio cholerae infection_Homo sapiens_hsa051100.48021593
102Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47856641
103Cysteine and methionine metabolism_Homo sapiens_hsa002700.47299484
104Adipocytokine signaling pathway_Homo sapiens_hsa049200.47027168
105Renin secretion_Homo sapiens_hsa049240.46976803
106Insulin secretion_Homo sapiens_hsa049110.46569118
107Dilated cardiomyopathy_Homo sapiens_hsa054140.44572980
108ABC transporters_Homo sapiens_hsa020100.44393053
109Collecting duct acid secretion_Homo sapiens_hsa049660.43803597
110Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42305287
111Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.42234823
112Systemic lupus erythematosus_Homo sapiens_hsa053220.41682120
113Nicotine addiction_Homo sapiens_hsa050330.40399367
114Olfactory transduction_Homo sapiens_hsa047400.40351279
115Prion diseases_Homo sapiens_hsa050200.39309413
116Staphylococcus aureus infection_Homo sapiens_hsa051500.38443258
117Morphine addiction_Homo sapiens_hsa050320.37886359
118Insulin resistance_Homo sapiens_hsa049310.37266863
119Caffeine metabolism_Homo sapiens_hsa002320.36115649
120Sulfur relay system_Homo sapiens_hsa041220.36046408
121Glutathione metabolism_Homo sapiens_hsa004800.35489885
122Gastric acid secretion_Homo sapiens_hsa049710.35044762
123Drug metabolism - other enzymes_Homo sapiens_hsa009830.34637734
124Pancreatic secretion_Homo sapiens_hsa049720.33839614
125Long-term potentiation_Homo sapiens_hsa047200.33350284
126Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.32735927
127Circadian entrainment_Homo sapiens_hsa047130.32031784
128Steroid biosynthesis_Homo sapiens_hsa001000.31979775
129Calcium signaling pathway_Homo sapiens_hsa040200.31079216
130Glutamatergic synapse_Homo sapiens_hsa047240.30916877
131Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.29452511
132Vitamin digestion and absorption_Homo sapiens_hsa049770.29423739
133Aldosterone synthesis and secretion_Homo sapiens_hsa049250.28904442
134Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.27564765
135Insulin signaling pathway_Homo sapiens_hsa049100.27211875
136AMPK signaling pathway_Homo sapiens_hsa041520.26715843
137Dopaminergic synapse_Homo sapiens_hsa047280.26605804
138Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.24822639
139Taste transduction_Homo sapiens_hsa047420.24343302
140Synaptic vesicle cycle_Homo sapiens_hsa047210.23660348
141Lysosome_Homo sapiens_hsa041420.23407148

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