SMIM2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1homocysteine metabolic process (GO:0050667)8.93919546
2regulation of plasminogen activation (GO:0010755)8.25671421
3microtubule nucleation (GO:0007020)7.44233748
4sulfur amino acid catabolic process (GO:0000098)7.38431297
5folic acid-containing compound biosynthetic process (GO:0009396)6.91230236
6rRNA methylation (GO:0031167)6.66928221
7acrosome reaction (GO:0007340)6.44546993
8cysteine metabolic process (GO:0006534)6.39875750
9organic cation transport (GO:0015695)6.29886374
10RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)6.25936007
11tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)6.25936007
12purine nucleotide salvage (GO:0032261)6.21785790
13sperm motility (GO:0030317)6.19101328
14desmosome organization (GO:0002934)5.77219155
15polyamine biosynthetic process (GO:0006596)5.75878194
16white fat cell differentiation (GO:0050872)5.73450810
17positive regulation of endothelial cell differentiation (GO:0045603)5.62116187
18rRNA modification (GO:0000154)5.60980518
19axonemal dynein complex assembly (GO:0070286)5.60467509
20chromosome condensation (GO:0030261)5.49780308
21adenosine metabolic process (GO:0046085)5.41255953
22fusion of sperm to egg plasma membrane (GO:0007342)5.32639964
23epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)5.31687037
24negative regulation of DNA biosynthetic process (GO:2000279)5.23787174
25multicellular organism reproduction (GO:0032504)5.13693495
26sperm-egg recognition (GO:0035036)5.00401908
27binding of sperm to zona pellucida (GO:0007339)4.91154193
28cilium or flagellum-dependent cell motility (GO:0001539)4.81147012
29DNA packaging (GO:0006323)4.79084570
30spermatid development (GO:0007286)4.69262203
31pteridine-containing compound biosynthetic process (GO:0042559)4.68795256
32galactose catabolic process (GO:0019388)4.65320613
33acrosome assembly (GO:0001675)4.56380969
34single strand break repair (GO:0000012)4.50608386
35inner ear receptor cell development (GO:0060119)4.49287858
36single fertilization (GO:0007338)4.46969299
37regulation of branching involved in salivary gland morphogenesis (GO:0060693)4.42365558
38cell migration involved in heart development (GO:0060973)4.34351411
39cell-cell recognition (GO:0009988)4.28694966
40primary amino compound metabolic process (GO:1901160)4.21241815
41protein-chromophore linkage (GO:0018298)4.20760498
42galactose metabolic process (GO:0006012)4.20451228
43regulation of vitamin D biosynthetic process (GO:0060556)4.14192895
44alternative mRNA splicing, via spliceosome (GO:0000380)4.12699514
45negative regulation of catenin import into nucleus (GO:0035414)4.08201330
46negative regulation of Ras GTPase activity (GO:0034261)4.06668161
47negative regulation of keratinocyte proliferation (GO:0010839)4.04640275
48IMP biosynthetic process (GO:0006188)4.04073355
49spermatid nucleus differentiation (GO:0007289)4.02301896
50polyamine metabolic process (GO:0006595)4.00396906
51reproduction (GO:0000003)3.98649389
52plasma membrane fusion (GO:0045026)3.95595377
53regulation of gonadotropin secretion (GO:0032276)3.92309078
54response to vitamin A (GO:0033189)3.91434161
55cochlea development (GO:0090102)3.90976521
56regulation of endothelial cell differentiation (GO:0045601)3.89394987
57mitochondrial RNA metabolic process (GO:0000959)3.88473783
58regulation of transcription involved in cell fate commitment (GO:0060850)3.84831384
59regulation of tight junction assembly (GO:2000810)3.84681359
60regulation of oxidative phosphorylation (GO:0002082)3.83058839
61L-serine metabolic process (GO:0006563)3.82411707
62placenta development (GO:0001890)3.76269634
63aminoglycoside antibiotic metabolic process (GO:0030647)3.76052642
64microtubule depolymerization (GO:0007019)3.75365586
65motile cilium assembly (GO:0044458)3.74581765
66cartilage morphogenesis (GO:0060536)3.72559788
67histone exchange (GO:0043486)3.71754932
68IMP metabolic process (GO:0046040)3.68458319
69serine family amino acid catabolic process (GO:0009071)3.66143618
70cellular biogenic amine biosynthetic process (GO:0042401)3.65435273
71folic acid-containing compound metabolic process (GO:0006760)3.55270732
72amine biosynthetic process (GO:0009309)3.54380720
73male meiosis (GO:0007140)3.51851182
74regulation of vitamin metabolic process (GO:0030656)3.49769469
75sperm capacitation (GO:0048240)3.46559591
76COPII vesicle coating (GO:0048208)3.46173777
77nucleotide salvage (GO:0043173)3.46033697
78tetrahydrofolate metabolic process (GO:0046653)3.45410643
79sulfur amino acid biosynthetic process (GO:0000097)3.45406185
80serine family amino acid biosynthetic process (GO:0009070)3.36739859
81glycoside metabolic process (GO:0016137)3.33643641
82calcium ion-dependent exocytosis (GO:0017156)3.29678763
83peptidyl-proline hydroxylation (GO:0019511)3.29677076
84coenzyme catabolic process (GO:0009109)3.28835128
85innervation (GO:0060384)3.28368688
86response to mercury ion (GO:0046689)3.26566458
87regulation of sequestering of triglyceride (GO:0010889)3.24523828
88heme transport (GO:0015886)3.20483944
89growth hormone secretion (GO:0030252)3.17116061
90energy homeostasis (GO:0097009)3.15798366
91spermatogenesis (GO:0007283)3.15040432
92male gamete generation (GO:0048232)3.13422862
93negative regulation of stem cell proliferation (GO:2000647)3.12213642
94regulation of phosphoprotein phosphatase activity (GO:0043666)3.11121578
954-hydroxyproline metabolic process (GO:0019471)3.10458511
96histone H4-K12 acetylation (GO:0043983)3.10184946
97fertilization (GO:0009566)3.02181356
98phosphatidylglycerol biosynthetic process (GO:0006655)3.01389125
99microtubule polymerization or depolymerization (GO:0031109)3.01024351
100cellular response to zinc ion (GO:0071294)2.97914338

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.24405298
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.51217542
3THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.62130584
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.45861379
5VDR_22108803_ChIP-Seq_LS180_Human2.30677925
6ESR1_20079471_ChIP-ChIP_T-47D_Human2.17517846
7CTBP1_25329375_ChIP-Seq_LNCAP_Human2.13233767
8MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.07024650
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse10.1404323
10BP1_19119308_ChIP-ChIP_Hs578T_Human1.89784052
11SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.87178721
12OCT1_27270436_Chip-Seq_PROSTATE_Human1.80116081
13YY1_22570637_ChIP-Seq_MALME-3M_Human1.76994972
14P68_20966046_ChIP-Seq_HELA_Human1.76753583
15CTCF_27219007_Chip-Seq_Bcells_Human1.68747907
16NANOG_20526341_ChIP-Seq_ESCs_Human1.65164246
17OCT4_20526341_ChIP-Seq_ESCs_Human1.63767062
18UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.62500539
19VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.61637089
20CDX2_22108803_ChIP-Seq_LS180_Human1.60384267
21CBP_20019798_ChIP-Seq_JUKART_Human1.58524223
22IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.58524223
23FUS_26573619_Chip-Seq_HEK293_Human1.58262922
24ERG_20517297_ChIP-Seq_VCAP_Human1.57224141
25SOX2_22085726_ChIP-Seq_NPCs_Mouse1.56919369
26SMC4_20622854_ChIP-Seq_HELA_Human1.52169075
27RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.51283280
28FOXH1_21741376_ChIP-Seq_ESCs_Human1.47624534
29STAT1_20625510_ChIP-Seq_HELA_Human1.46692499
30NCOR_22424771_ChIP-Seq_293T_Human1.45411370
31LXR_22292898_ChIP-Seq_THP-1_Human1.45370225
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.45328802
33RAC3_21632823_ChIP-Seq_H3396_Human1.44842400
34EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.44119665
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.44069590
36P300_27268052_Chip-Seq_Bcells_Human1.44068060
37CTCF_20526341_ChIP-Seq_ESCs_Human1.42591040
38PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.42279870
39ERA_21632823_ChIP-Seq_H3396_Human1.41575832
40ER_23166858_ChIP-Seq_MCF-7_Human1.39333840
41EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.38879736
42RAD21_21589869_ChIP-Seq_MESCs_Mouse1.37131820
43TP63_22573176_ChIP-Seq_HFKS_Human1.35265602
44BCOR_27268052_Chip-Seq_Bcells_Human1.35127061
45CEBPB_22108803_ChIP-Seq_LS180_Human1.33968882
46EZH2_22144423_ChIP-Seq_EOC_Human1.33750191
47PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.32532956
48EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.32510577
49EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.31493258
50SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.31250744
51ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.30657096
52MYC_19829295_ChIP-Seq_ESCs_Human1.30282371
53CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.27541945
54E2F1_20622854_ChIP-Seq_HELA_Human1.26863582
55TAF2_19829295_ChIP-Seq_ESCs_Human1.26183731
56RUNX2_22187159_ChIP-Seq_PCA_Human1.25289486
57SMAD4_21741376_ChIP-Seq_EPCs_Human1.24465834
58PHF8_20622854_ChIP-Seq_HELA_Human1.22095330
59P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.21787408
60HOXB7_26014856_ChIP-Seq_BT474_Human1.21277131
61PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.20660109
62IRF8_22096565_ChIP-ChIP_GC-B_Human1.20316897
63ARNT_22903824_ChIP-Seq_MCF-7_Human1.19878821
64CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.19818214
65TBL1_22424771_ChIP-Seq_293T_Human1.18383568
66TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17476141
67PHF8_20622853_ChIP-Seq_HELA_Human1.16879967
68SPI1_20517297_ChIP-Seq_HL60_Human1.16734373
69FOXH1_21741376_ChIP-Seq_EPCs_Human1.16551595
70KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15294055
71BCL6_27268052_Chip-Seq_Bcells_Human1.15168085
72AR_21909140_ChIP-Seq_LNCAP_Human1.11166839
73TP53_18474530_ChIP-ChIP_U2OS_Human1.10573388
74WDR5_24793694_ChIP-Seq_LNCAP_Human1.10314388
75CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09365556
76SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07386599
77GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.06477863
78HNFA_21074721_ChIP-Seq_CACO-2_Human1.06242454
79RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.04712467
80GBX2_23144817_ChIP-Seq_PC3_Human1.04078078
81ZNF274_21170338_ChIP-Seq_K562_Hela1.04061642
82ETV2_25802403_ChIP-Seq_MESCs_Mouse1.03667064
83NFYB_21822215_ChIP-Seq_K562_Human1.01688291
84BCAT_22108803_ChIP-Seq_LS180_Human1.01668454
85TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01053190
86RXR_22158963_ChIP-Seq_LIVER_Mouse0.99749007
87FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.99201284
88CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.99107830
89AR_25329375_ChIP-Seq_VCAP_Human0.98858257
90P300_19829295_ChIP-Seq_ESCs_Human0.98226553
91ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.98137680
92BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.95037655
93GATA6_21074721_ChIP-Seq_CACO-2_Human0.94551039
94ZNF263_19887448_ChIP-Seq_K562_Human0.94488750
95GATA3_21878914_ChIP-Seq_MCF-7_Human0.93620586
96SOX11_22085726_ChIP-Seq_ESNs_Mouse0.93318330
97AHR_22903824_ChIP-Seq_MCF-7_Human0.92556870
98STAT6_21828071_ChIP-Seq_BEAS2B_Human0.90780726
99SOX2_19829295_ChIP-Seq_ESCs_Human0.88881664
100NANOG_19829295_ChIP-Seq_ESCs_Human0.88881664

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization6.46683825
2MP0005360_urolithiasis6.21969776
3MP0005670_abnormal_white_adipose5.83990434
4MP0005646_abnormal_pituitary_gland3.94124627
5MP0003705_abnormal_hypodermis_morpholog3.68946027
6MP0008995_early_reproductive_senescence3.31057707
7MP0001661_extended_life_span3.17211400
8MP0003183_abnormal_peptide_metabolism3.02326129
9MP0000013_abnormal_adipose_tissue3.01689353
10MP0003806_abnormal_nucleotide_metabolis2.94231305
11MP0002132_abnormal_respiratory_system2.75755225
12MP0003698_abnormal_male_reproductive2.41956498
13MP0005377_hearing/vestibular/ear_phenot2.32863200
14MP0003878_abnormal_ear_physiology2.32863200
15MP0002736_abnormal_nociception_after2.17733087
16MP0004885_abnormal_endolymph2.02052096
17MP0001929_abnormal_gametogenesis2.01391193
18MP0009697_abnormal_copulation1.98375819
19MP0003315_abnormal_perineum_morphology1.89855538
20MP0005332_abnormal_amino_acid1.86652974
21MP0001764_abnormal_homeostasis1.78725738
22MP0000003_abnormal_adipose_tissue1.74583328
23MP0002160_abnormal_reproductive_system1.69583690
24MP0000516_abnormal_urinary_system1.64023843
25MP0005367_renal/urinary_system_phenotyp1.64023843
26MP0003724_increased_susceptibility_to1.62514324
27MP0002938_white_spotting1.56335039
28MP0000678_abnormal_parathyroid_gland1.55948947
29MP0001968_abnormal_touch/_nociception1.54663305
30MP0008004_abnormal_stomach_pH1.53261874
31MP0008872_abnormal_physiological_respon1.52335615
32MP0002138_abnormal_hepatobiliary_system1.47218603
33MP0000534_abnormal_ureter_morphology1.37955025
34MP0000749_muscle_degeneration1.36168997
35MP0002139_abnormal_hepatobiliary_system1.35728108
36MP0002161_abnormal_fertility/fecundity1.29355410
37MP0002210_abnormal_sex_determination1.22066541
38MP0004185_abnormal_adipocyte_glucose1.21748793
39MP0002735_abnormal_chemical_nociception1.20020307
40MP0004233_abnormal_muscle_weight1.18552624
41MP0005647_abnormal_sex_gland1.16521604
42MP0003186_abnormal_redox_activity1.15420483
43MP0004147_increased_porphyrin_level1.13595408
44MP0005085_abnormal_gallbladder_physiolo1.11199425
45MP0000653_abnormal_sex_gland1.08378232
46MP0001145_abnormal_male_reproductive1.07363350
47MP0001905_abnormal_dopamine_level1.05775290
48MP0002837_dystrophic_cardiac_calcinosis1.00753104
49MP0000026_abnormal_inner_ear1.00678415
50MP0003045_fibrosis1.00483591
51MP0009643_abnormal_urine_homeostasis0.97535174
52MP0004043_abnormal_pH_regulation0.97226103
53MP0002295_abnormal_pulmonary_circulatio0.96998285
54MP0001756_abnormal_urination0.96221466
55MP0001348_abnormal_lacrimal_gland0.95898159
56MP0005551_abnormal_eye_electrophysiolog0.95388686
57MP0003718_maternal_effect0.94988183
58MP0004019_abnormal_vitamin_homeostasis0.88786603
59MP0005636_abnormal_mineral_homeostasis0.88369182
60MP0003879_abnormal_hair_cell0.84785856
61MP0005376_homeostasis/metabolism_phenot0.84510066
62MP0001963_abnormal_hearing_physiology0.83837125
63MP0001486_abnormal_startle_reflex0.82443872
64MP0002876_abnormal_thyroid_physiology0.81822899
65MP0001851_eye_inflammation0.81535020
66MP0002269_muscular_atrophy0.81031984
67MP0009115_abnormal_fat_cell0.80530090
68MP0001944_abnormal_pancreas_morphology0.79619980
69MP0005253_abnormal_eye_physiology0.79024753
70MP0002127_abnormal_cardiovascular_syste0.78868596
71MP0010368_abnormal_lymphatic_system0.77833091
72MP0002396_abnormal_hematopoietic_system0.77531294
73MP0001485_abnormal_pinna_reflex0.76410692
74MP0004130_abnormal_muscle_cell0.74584791
75MP0005164_abnormal_response_to0.73676920
76MP0001270_distended_abdomen0.73244856
77MP0001765_abnormal_ion_homeostasis0.72029230
78MP0002095_abnormal_skin_pigmentation0.71559731
79MP0000747_muscle_weakness0.69723332
80MP0000681_abnormal_thyroid_gland0.68232039
81MP0005595_abnormal_vascular_smooth0.67796592
82MP0000647_abnormal_sebaceous_gland0.65692401
83MP0000230_abnormal_systemic_arterial0.64290552
84MP0000631_abnormal_neuroendocrine_gland0.63912904
85MP0003646_muscle_fatigue0.63907582
86MP0005319_abnormal_enzyme/_coenzyme0.62911320
87MP0003638_abnormal_response/metabolism_0.62263446
88MP0004036_abnormal_muscle_relaxation0.60934610
89MP0005365_abnormal_bile_salt0.60915152
90MP0005389_reproductive_system_phenotype0.59931629
91MP0002078_abnormal_glucose_homeostasis0.59869456
92MP0002069_abnormal_eating/drinking_beha0.58768556
93MP0004084_abnormal_cardiac_muscle0.57998946
94MP0005334_abnormal_fat_pad0.57889798
95MP0002108_abnormal_muscle_morphology0.57755971
96MP0005666_abnormal_adipose_tissue0.55276941
97MP0003942_abnormal_urinary_system0.55088961
98MP0001849_ear_inflammation0.53825551
99MP0002254_reproductive_system_inflammat0.53264892
100MP0000762_abnormal_tongue_morphology0.53113695

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of pyruvate family amino acid metabolism (HP:0010915)8.10193528
2Abnormality of alanine metabolism (HP:0010916)8.10193528
3Hyperalaninemia (HP:0003348)8.10193528
4Congenital sensorineural hearing impairment (HP:0008527)6.46027683
5Esophageal varix (HP:0002040)5.50532140
6Constricted visual fields (HP:0001133)5.17116457
7Spontaneous hematomas (HP:0007420)5.10896189
8White forelock (HP:0002211)4.43507807
9Abnormal umbilical cord blood vessels (HP:0011403)4.07421571
10Single umbilical artery (HP:0001195)4.07421571
11Abnormality of the fetal cardiovascular system (HP:0010948)4.07421571
12Generalized aminoaciduria (HP:0002909)4.04573054
13Patchy hypopigmentation of hair (HP:0011365)3.94116737
14Abnormal respiratory motile cilium morphology (HP:0005938)3.84292351
15Abnormal respiratory epithelium morphology (HP:0012253)3.84292351
16Myocardial infarction (HP:0001658)3.64969813
17Decreased electroretinogram (ERG) amplitude (HP:0000654)3.63714285
18Hypoalphalipoproteinemia (HP:0003233)3.60469442
19Conjunctival telangiectasia (HP:0000524)3.54416958
20Abnormality of serum amino acid levels (HP:0003112)3.36524383
21Attenuation of retinal blood vessels (HP:0007843)3.36473108
22Conjugated hyperbilirubinemia (HP:0002908)3.28255688
23Homocystinuria (HP:0002156)3.28068217
24Abnormality of homocysteine metabolism (HP:0010919)3.28068217
25Chronic hepatic failure (HP:0100626)3.27082648
26Anorexia (HP:0002039)3.25898896
27Abnormality of sulfur amino acid metabolism (HP:0004339)3.16293653
28Action tremor (HP:0002345)3.14753483
29Birth length less than 3rd percentile (HP:0003561)3.12110986
30Tubulointerstitial nephritis (HP:0001970)2.94057985
31Cone-rod dystrophy (HP:0000548)2.92989793
32Dynein arm defect of respiratory motile cilia (HP:0012255)2.92513410
33Absent/shortened dynein arms (HP:0200106)2.92513410
34Abnormality of the vasculature of the conjunctiva (HP:0008054)2.76341443
35Resting tremor (HP:0002322)2.71721500
36Pulmonary embolism (HP:0002204)2.61262289
37Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.61110531
38Severe visual impairment (HP:0001141)2.59212334
39Pigmentary retinal degeneration (HP:0001146)2.56784822
40Hyperuricemia (HP:0002149)2.54709069
41Increased purine levels (HP:0004368)2.54709069
42Insulin-resistant diabetes mellitus (HP:0000831)2.54165835
43Visceral angiomatosis (HP:0100761)2.53606912
44Abnormal ciliary motility (HP:0012262)2.53493715
45Tetany (HP:0001281)2.53313889
46Abnormal respiratory motile cilium physiology (HP:0012261)2.51857532
47Ileus (HP:0002595)2.49744172
48Infertility (HP:0000789)2.46831624
49Abnormality of the umbilical cord (HP:0010881)2.43749622
50Poor speech (HP:0002465)2.41452592
51Maternal diabetes (HP:0009800)2.38992581
52Portal hypertension (HP:0001409)2.35718715
53Chronic otitis media (HP:0000389)2.30924919
54Myopathic facies (HP:0002058)2.29450434
55Hypoplastic left heart (HP:0004383)2.26696460
56Fatigue (HP:0012378)2.24303586
57Arteriovenous malformation (HP:0100026)2.23558009
58Heterochromia iridis (HP:0001100)2.22279405
59Oligomenorrhea (HP:0000876)2.22053554
60Hemangiomatosis (HP:0007461)2.20101808
61Abnormality of the hepatic vasculature (HP:0006707)2.19342165
62Reduced antithrombin III activity (HP:0001976)2.18290133
63Proximal tubulopathy (HP:0000114)2.16194742
64Hypolipoproteinemia (HP:0010981)2.11535915
65Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.10128385
66Chorioretinal atrophy (HP:0000533)2.07388699
67Decreased subcutaneous fat (HP:0001002)2.06097928
68Thrombophlebitis (HP:0004418)2.05950356
69Focal segmental glomerulosclerosis (HP:0000097)2.03106238
70Widely patent fontanelles and sutures (HP:0004492)2.02994636
71Chronic sinusitis (HP:0011109)1.99971519
72Paralysis (HP:0003470)1.98691183
73Hypomagnesemia (HP:0002917)1.96374117
74Reduced subcutaneous adipose tissue (HP:0003758)1.95524925
75Hypoplastic heart (HP:0001961)1.93213880
76Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.92020237
77Hyperglycinemia (HP:0002154)1.88429422
78Biconcave vertebral bodies (HP:0004586)1.87513576
79Abnormality of purine metabolism (HP:0004352)1.86897692
80Metabolic acidosis (HP:0001942)1.82477613
81Long clavicles (HP:0000890)1.81772692
82Cortical visual impairment (HP:0100704)1.81079496
83Abnormality of DNA repair (HP:0003254)1.78985643
84Abnormality of nucleobase metabolism (HP:0010932)1.78432805
85Hyperphosphaturia (HP:0003109)1.77520572
86Abnormality of aromatic amino acid family metabolism (HP:0004338)1.74202008
87Rhinitis (HP:0012384)1.73816827
88Toxemia of pregnancy (HP:0100603)1.73657444
89Complete atrioventricular canal defect (HP:0001674)1.73433155
90Aplasia/Hypoplasia of the sacrum (HP:0008517)1.71685663
91Type II diabetes mellitus (HP:0005978)1.71330569
92Petechiae (HP:0000967)1.71077137
93Cavernous hemangioma (HP:0001048)1.68654676
94Abnormality of the renal collecting system (HP:0004742)1.68173713
95Pendular nystagmus (HP:0012043)1.67080462
96Duplicated collecting system (HP:0000081)1.66284341
97Hypopigmentation of the fundus (HP:0007894)1.65995943
98Nausea (HP:0002018)1.65960708
99Diaphragmatic weakness (HP:0009113)1.65827506
100Glycosuria (HP:0003076)1.65185015

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PINK16.29482872
2MAP3K34.52109359
3MAP2K33.79637518
4ACVR1B3.53151048
5PLK43.37270521
6SGK4942.74969368
7SGK2232.74969368
8FGR2.73716664
9MST1R2.64775563
10JAK32.63352223
11STK392.62670971
12WNK42.52914159
13CDK92.46950875
14RPS6KB22.27975201
15MARK32.25149398
16SGK21.96912236
17OXSR11.94462290
18NTRK21.76195842
19CCNB11.74028309
20ZAK1.60627737
21MAP4K21.54028076
22OBSCN1.52041585
23MYLK1.48667429
24STK381.46608897
25EPHB21.44428562
26TESK11.40760757
27DDR21.38123555
28PRKG21.33456789
29INSRR1.32346511
30STK38L1.30425809
31NTRK31.30352349
32PLK21.29550979
33TLK11.29188124
34SGK31.29038906
35NEK61.23622037
36MAP2K71.23589024
37MAPK151.17797850
38LMTK20.94064116
39MAP2K10.94031612
40CSNK1A10.82101263
41IRAK20.81740861
42NEK20.81134179
43ADRBK10.80643724
44CAMK10.80470172
45PRKD30.77760615
46LATS10.75438806
47MAP3K110.75333484
48LATS20.74851205
49FRK0.73893347
50RPS6KA50.73614798
51MAP3K10.71807717
52RPS6KB10.71226002
53MTOR0.69650195
54CDK70.67717926
55DYRK20.67286555
56RPS6KA10.67089629
57MAP3K90.64593451
58ARAF0.63013501
59AURKA0.61892858
60MET0.60724952
61PTK2B0.60511975
62DYRK1B0.56441194
63PDPK10.54686381
64BMPR1B0.54603495
65PRKCQ0.52360187
66PIK3CG0.46970720
67SGK10.46842944
68PHKG20.44663761
69PHKG10.44663761
70CDK50.43543036
71CAMK2G0.41911311
72CDK30.40149929
73PNCK0.39033943
74NME20.38615686
75PAK10.37634613
76BRSK20.36694882
77ROCK10.36295055
78PAK40.34415176
79CAMK2B0.33261174
80MAP4K10.32674729
81EGFR0.32374908
82PRKCE0.31851906
83TIE10.31551603
84AKT20.31388786
85PRKG10.30794830
86PDK10.29976799
87BRD40.28337873
88ADRBK20.27321126
89CAMK2D0.27031160
90MUSK0.25924627
91UHMK10.24676154
92PKN10.24496371
93STK30.22273948
94VRK10.19068649
95PRKCA0.18555233
96CDK80.18378936
97PRKCD0.17845131
98JAK20.16108370
99BRSK10.16054559
100TNIK0.16023987

Predicted pathways (KEGG)

RankGene SetZ-score
1Arginine biosynthesis_Homo sapiens_hsa002205.06743526
2One carbon pool by folate_Homo sapiens_hsa006703.65618231
3Collecting duct acid secretion_Homo sapiens_hsa049663.26913377
4Sulfur metabolism_Homo sapiens_hsa009203.18193737
5Maturity onset diabetes of the young_Homo sapiens_hsa049502.81405687
6Sulfur relay system_Homo sapiens_hsa041222.63493357
7Olfactory transduction_Homo sapiens_hsa047402.46074651
8Fatty acid biosynthesis_Homo sapiens_hsa000612.32053219
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.22026149
10Nitrogen metabolism_Homo sapiens_hsa009102.16047582
11Selenocompound metabolism_Homo sapiens_hsa004502.10618421
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.01375551
13Galactose metabolism_Homo sapiens_hsa000522.00183392
14Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.99355239
15Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.91316944
16Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.75709831
17Retinol metabolism_Homo sapiens_hsa008301.75542761
18Cysteine and methionine metabolism_Homo sapiens_hsa002701.74134849
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.69419443
20GABAergic synapse_Homo sapiens_hsa047271.66349190
21Phenylalanine metabolism_Homo sapiens_hsa003601.65772004
22Morphine addiction_Homo sapiens_hsa050321.63374703
23Butanoate metabolism_Homo sapiens_hsa006501.60785901
24Biosynthesis of amino acids_Homo sapiens_hsa012301.60461341
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.59175103
26Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.49881926
27Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.48274953
28Synaptic vesicle cycle_Homo sapiens_hsa047211.46141588
29Arginine and proline metabolism_Homo sapiens_hsa003301.40144248
30Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.37384753
31Regulation of autophagy_Homo sapiens_hsa041401.37364726
32Chemical carcinogenesis_Homo sapiens_hsa052041.37244881
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.28629058
34Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.27853881
35Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.27114612
36Nicotine addiction_Homo sapiens_hsa050331.20892500
37Folate biosynthesis_Homo sapiens_hsa007901.19817090
38Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.19639926
39Alcoholism_Homo sapiens_hsa050341.14706995
40Vitamin digestion and absorption_Homo sapiens_hsa049771.12901187
41PPAR signaling pathway_Homo sapiens_hsa033201.08675924
42Vibrio cholerae infection_Homo sapiens_hsa051101.01985029
43Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.01260781
44Glycerophospholipid metabolism_Homo sapiens_hsa005640.98826830
45Systemic lupus erythematosus_Homo sapiens_hsa053220.96688186
46Taste transduction_Homo sapiens_hsa047420.96293699
47Serotonergic synapse_Homo sapiens_hsa047260.95778428
48Tyrosine metabolism_Homo sapiens_hsa003500.95348195
49Circadian entrainment_Homo sapiens_hsa047130.88613907
50Cyanoamino acid metabolism_Homo sapiens_hsa004600.87603830
51Peroxisome_Homo sapiens_hsa041460.86667688
52mRNA surveillance pathway_Homo sapiens_hsa030150.85789123
53Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.83670519
54Other glycan degradation_Homo sapiens_hsa005110.82976294
55Glutamatergic synapse_Homo sapiens_hsa047240.78568148
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.74276673
57Glutathione metabolism_Homo sapiens_hsa004800.73929286
58Basal transcription factors_Homo sapiens_hsa030220.73901004
59Starch and sucrose metabolism_Homo sapiens_hsa005000.70910538
60Metabolic pathways_Homo sapiens_hsa011000.68110996
61Propanoate metabolism_Homo sapiens_hsa006400.66211305
62Fatty acid degradation_Homo sapiens_hsa000710.65797788
63Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.64594352
64ABC transporters_Homo sapiens_hsa020100.64489012
65Pentose and glucuronate interconversions_Homo sapiens_hsa000400.63244154
66Hedgehog signaling pathway_Homo sapiens_hsa043400.60922752
67Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.60467214
68RNA transport_Homo sapiens_hsa030130.58926636
69Drug metabolism - other enzymes_Homo sapiens_hsa009830.58682480
70Phagosome_Homo sapiens_hsa041450.58392190
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57163496
72Gap junction_Homo sapiens_hsa045400.53101081
73Purine metabolism_Homo sapiens_hsa002300.51535273
74Fat digestion and absorption_Homo sapiens_hsa049750.49140459
75Cholinergic synapse_Homo sapiens_hsa047250.48593528
76Mineral absorption_Homo sapiens_hsa049780.48220093
77Dopaminergic synapse_Homo sapiens_hsa047280.47991507
78Carbon metabolism_Homo sapiens_hsa012000.47642615
79beta-Alanine metabolism_Homo sapiens_hsa004100.46634515
80Complement and coagulation cascades_Homo sapiens_hsa046100.45039181
81Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.43384696
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42774661
83Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.40427816
84Bile secretion_Homo sapiens_hsa049760.40116630
85Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39846025
86Renin secretion_Homo sapiens_hsa049240.39208176
87Fanconi anemia pathway_Homo sapiens_hsa034600.38270129
88Caffeine metabolism_Homo sapiens_hsa002320.36323960
89Tryptophan metabolism_Homo sapiens_hsa003800.34790579
90Glycerolipid metabolism_Homo sapiens_hsa005610.32124999
91Oxidative phosphorylation_Homo sapiens_hsa001900.28958904
92Arachidonic acid metabolism_Homo sapiens_hsa005900.26829438
93Linoleic acid metabolism_Homo sapiens_hsa005910.26295015
94Longevity regulating pathway - mammal_Homo sapiens_hsa042110.25879905
95Thyroid cancer_Homo sapiens_hsa052160.25718286
96Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.24520415
97Base excision repair_Homo sapiens_hsa034100.24277513
98Fatty acid metabolism_Homo sapiens_hsa012120.23706773
99Sphingolipid metabolism_Homo sapiens_hsa006000.20499011
100Dorso-ventral axis formation_Homo sapiens_hsa043200.18927982

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