SMIM22

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)6.26852541
23-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)6.08256599
3purine ribonucleoside bisphosphate metabolic process (GO:0034035)6.08256599
4COPI coating of Golgi vesicle (GO:0048205)5.91978506
5Golgi transport vesicle coating (GO:0048200)5.91978506
6endocrine pancreas development (GO:0031018)5.91254205
7intestinal epithelial cell development (GO:0060576)5.48505658
8regulation of autophagic vacuole assembly (GO:2000785)5.46338658
9negative regulation of keratinocyte proliferation (GO:0010839)5.38666499
10glandular epithelial cell differentiation (GO:0002067)5.30206593
11keratinocyte development (GO:0003334)5.18556148
12cytidine catabolic process (GO:0006216)5.14410179
13cytidine deamination (GO:0009972)5.14410179
14cytidine metabolic process (GO:0046087)5.14410179
15cilium movement (GO:0003341)4.96229093
16GDP-mannose metabolic process (GO:0019673)4.90286120
17cilium or flagellum-dependent cell motility (GO:0001539)4.75312347
18epithelial cilium movement (GO:0003351)4.72073701
19maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.63597881
20intestinal absorption (GO:0050892)4.61065173
21axoneme assembly (GO:0035082)4.58968626
22peptide hormone processing (GO:0016486)4.44196316
23epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.35671393
24protein retention in ER lumen (GO:0006621)4.35617094
25calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.34460565
26signal peptide processing (GO:0006465)4.34279578
27positive regulation of respiratory burst (GO:0060267)4.29201013
28regulation of vacuole organization (GO:0044088)4.24577013
29sulfate transmembrane transport (GO:1902358)4.17946884
30intestinal cholesterol absorption (GO:0030299)4.07793880
31COPII vesicle coating (GO:0048208)4.06920935
32nucleotide-sugar biosynthetic process (GO:0009226)4.03843692
33pyrimidine ribonucleoside catabolic process (GO:0046133)3.96785147
34pyrimidine-containing compound transmembrane transport (GO:0072531)3.94212644
35glutathione derivative metabolic process (GO:1901685)3.86682482
36glutathione derivative biosynthetic process (GO:1901687)3.86682482
37regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.85141266
38primary alcohol catabolic process (GO:0034310)3.77548889
39regulation of guanylate cyclase activity (GO:0031282)3.77348214
40sulfur amino acid catabolic process (GO:0000098)3.77272938
41vitamin transmembrane transport (GO:0035461)3.75176567
42ethanol metabolic process (GO:0006067)3.73212130
43sphingomyelin metabolic process (GO:0006684)3.61348751
44oligosaccharide biosynthetic process (GO:0009312)3.61291027
45mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.59787636
46motile cilium assembly (GO:0044458)3.57651494
47respiratory chain complex IV assembly (GO:0008535)3.56948046
48retinol metabolic process (GO:0042572)3.56824975
49sulfate transport (GO:0008272)3.56403815
50bundle of His cell to Purkinje myocyte communication (GO:0086069)3.55809446
51columnar/cuboidal epithelial cell development (GO:0002066)3.55446232
52cytochrome complex assembly (GO:0017004)3.53913180
53ethanol oxidation (GO:0006069)3.53323157
54cellular ketone body metabolic process (GO:0046950)3.51231301
55auditory receptor cell differentiation (GO:0042491)3.50361708
56glutathione biosynthetic process (GO:0006750)3.49725719
57negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.49355359
58epoxygenase P450 pathway (GO:0019373)3.47718685
59regulation of water loss via skin (GO:0033561)3.45323367
60negative regulation of T cell differentiation in thymus (GO:0033085)3.42942511
61regulation of keratinocyte proliferation (GO:0010837)3.42805508
62eosinophil chemotaxis (GO:0048245)3.41222042
63regulation of vitamin metabolic process (GO:0030656)3.38777999
64sequestering of metal ion (GO:0051238)3.38417409
65negative regulation of digestive system process (GO:0060457)3.37807145
66water-soluble vitamin biosynthetic process (GO:0042364)3.35093168
67UDP-N-acetylglucosamine metabolic process (GO:0006047)3.34316032
68retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.31860505
69protein neddylation (GO:0045116)3.29660021
70glucuronate metabolic process (GO:0019585)3.28674579
71uronic acid metabolic process (GO:0006063)3.28674579
72O-glycan processing (GO:0016266)3.27545894
73cobalamin metabolic process (GO:0009235)3.26516798
74positive regulation of insulin secretion (GO:0032024)3.26037275
75flavonoid metabolic process (GO:0009812)3.24337817
76cellular glucuronidation (GO:0052695)3.24065442
77signal transduction involved in regulation of gene expression (GO:0023019)3.23728546
78nonribosomal peptide biosynthetic process (GO:0019184)3.21728400
79drug transmembrane transport (GO:0006855)3.21296850
80protein maturation by protein folding (GO:0022417)3.19631099
81multicellular organismal water homeostasis (GO:0050891)3.18113485
82somite development (GO:0061053)3.16410116
83bile acid and bile salt transport (GO:0015721)3.16302816
84ribonucleoside bisphosphate metabolic process (GO:0033875)3.15117718
85nucleoside bisphosphate metabolic process (GO:0033865)3.15117718
86purine nucleoside bisphosphate metabolic process (GO:0034032)3.15117718
87exogenous drug catabolic process (GO:0042738)3.14084449
88respiratory electron transport chain (GO:0022904)3.13397544
89regulation of cilium movement (GO:0003352)3.13055177
90positive regulation of guanylate cyclase activity (GO:0031284)3.13002282
91positive regulation of glycoprotein biosynthetic process (GO:0010560)3.12614364
92regulation of protein glycosylation (GO:0060049)3.11332704
93primary alcohol metabolic process (GO:0034308)3.11168747
94alkaloid metabolic process (GO:0009820)3.10981126
95nitric oxide biosynthetic process (GO:0006809)3.09512327
96regulation of type B pancreatic cell apoptotic process (GO:2000674)3.09328765
97regulation of respiratory burst (GO:0060263)3.09328023
98establishment of skin barrier (GO:0061436)3.08981190
99xenobiotic catabolic process (GO:0042178)3.08413114
100electron transport chain (GO:0022900)3.08335934
101ketone body metabolic process (GO:1902224)3.06343779
102positive regulation of epidermal cell differentiation (GO:0045606)3.06037527
103antibacterial humoral response (GO:0019731)3.05031840
104angiotensin maturation (GO:0002003)3.04734714
105L-fucose catabolic process (GO:0042355)3.04526941
106fucose catabolic process (GO:0019317)3.04526941
107L-fucose metabolic process (GO:0042354)3.04526941
108eosinophil migration (GO:0072677)3.03217397
109drug metabolic process (GO:0017144)3.03075543
110maintenance of gastrointestinal epithelium (GO:0030277)3.02222156
111sulfur compound transport (GO:0072348)3.00226985
112nucleotide-sugar metabolic process (GO:0009225)2.99651105
113mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.97541588
114peptide catabolic process (GO:0043171)2.97318053
115tight junction assembly (GO:0070830)2.96640554
116negative regulation of macroautophagy (GO:0016242)2.96552071
117phenol-containing compound catabolic process (GO:0019336)2.96346580
118antimicrobial humoral response (GO:0019730)2.94800960
119positive regulation of glycoprotein metabolic process (GO:1903020)2.92274747
120diterpenoid biosynthetic process (GO:0016102)2.91758273
121L-ascorbic acid metabolic process (GO:0019852)2.91477597
122positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.90938305
123digestion (GO:0007586)2.89612340
124regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.89146279
125phosphatidylserine acyl-chain remodeling (GO:0036150)2.88542326
126glutathione metabolic process (GO:0006749)2.87818048
127proline biosynthetic process (GO:0006561)2.87676678
128erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.87458368
129L-phenylalanine metabolic process (GO:0006558)2.87458368
130nucleotide transmembrane transport (GO:1901679)2.86469948
131peptide metabolic process (GO:0006518)2.86248920
132drug catabolic process (GO:0042737)2.84826090
133positive regulation of peptide hormone secretion (GO:0090277)2.84729784
134renal absorption (GO:0070293)2.82118315
135vitamin transport (GO:0051180)2.81715140
136transcytosis (GO:0045056)2.80485505
137negative regulation of protein tyrosine kinase activity (GO:0061099)2.79163305
138exocrine pancreas development (GO:0031017)2.78980168
139digestive system process (GO:0022600)2.78341583
140ATP synthesis coupled proton transport (GO:0015986)2.77618292
141energy coupled proton transport, down electrochemical gradient (GO:0015985)2.77618292
142regulation of metalloenzyme activity (GO:0048552)2.75625790
143response to hepatocyte growth factor (GO:0035728)2.74253361
144cellular response to hepatocyte growth factor stimulus (GO:0035729)2.74253361
145one-carbon compound transport (GO:0019755)2.74166431
146proline metabolic process (GO:0006560)2.73043745
147cellular response to zinc ion (GO:0071294)2.72322527
148excretion (GO:0007588)2.71992964
149regulation of glucokinase activity (GO:0033131)2.70199516
150regulation of hexokinase activity (GO:1903299)2.70199516
151cellular response to vitamin D (GO:0071305)2.69712828
152positive regulation of peptide secretion (GO:0002793)2.68577148
153drug transport (GO:0015893)2.67926486
154regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.67059982
155phenylpropanoid metabolic process (GO:0009698)2.66017521
156L-phenylalanine catabolic process (GO:0006559)2.65521364
157erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.65521364
158phosphatidylinositol acyl-chain remodeling (GO:0036149)2.65476086
159regulation of bile acid biosynthetic process (GO:0070857)2.65349061
160neurotransmitter biosynthetic process (GO:0042136)2.62192036
161hydrogen peroxide catabolic process (GO:0042744)2.61086551
162vitamin biosynthetic process (GO:0009110)2.60856612
163arginine metabolic process (GO:0006525)2.57882682
164water homeostasis (GO:0030104)2.56908715
165short-chain fatty acid metabolic process (GO:0046459)2.56629493
166protein O-linked glycosylation (GO:0006493)2.56575667
167macroautophagy (GO:0016236)2.52822020
168hydrogen peroxide metabolic process (GO:0042743)2.52712075

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.27137013
2SOX2_27498859_Chip-Seq_STOMACH_Mouse3.69796906
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.18470576
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.16296848
5HNF4A_19761587_ChIP-ChIP_CACO-2_Human3.01496642
6PPARA_22158963_ChIP-Seq_LIVER_Mouse2.93018035
7STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.91366996
8ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.90217991
9RXR_22158963_ChIP-Seq_LIVER_Mouse2.71094827
10GATA4_25053715_ChIP-Seq_YYC3_Human2.69544236
11CDX2_20551321_ChIP-Seq_CACO-2_Human2.68716708
12SOX2_20726797_ChIP-Seq_SW620_Human2.53425263
13CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.45457348
14FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.32567978
15VDR_22108803_ChIP-Seq_LS180_Human2.28920058
16PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.27006858
17LXR_22158963_ChIP-Seq_LIVER_Mouse2.23769704
18EGR1_23403033_ChIP-Seq_LIVER_Mouse2.22360644
19GATA6_25053715_ChIP-Seq_YYC3_Human2.15875999
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.03038474
21ELF1_17652178_ChIP-ChIP_JURKAT_Human2.00174175
22STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.97653613
23ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.96528269
24ESR1_21235772_ChIP-Seq_MCF-7_Human1.95299687
25KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.91612065
26SRY_22984422_ChIP-ChIP_TESTIS_Rat1.89593250
27EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.83560680
28FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.81093525
29GABP_17652178_ChIP-ChIP_JURKAT_Human1.80738174
30SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.79868905
31TRIM28_21343339_ChIP-Seq_HEK293_Human1.74389683
32BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.74264152
33PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.73144705
34IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.71678796
35GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.70538230
36JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.64865240
37STAT6_21828071_ChIP-Seq_BEAS2B_Human1.59361980
38CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.59352974
39GATA3_24758297_ChIP-Seq_MCF-7_Human1.58331285
40IRF8_22096565_ChIP-ChIP_GC-B_Human1.58107632
41BCAT_22108803_ChIP-Seq_LS180_Human1.52929029
42CDX2_22108803_ChIP-Seq_LS180_Human1.46942906
43ZNF274_21170338_ChIP-Seq_K562_Hela1.45236042
44ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.44220072
45AHR_22903824_ChIP-Seq_MCF-7_Human1.40298127
46CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.39745694
47NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.39277958
48FOXA1_25552417_ChIP-Seq_VCAP_Human1.39218984
49DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.38276490
50ZNF217_24962896_ChIP-Seq_MCF-7_Human1.37972648
51ELK1_22589737_ChIP-Seq_MCF10A_Human1.37971607
52STAT1_20625510_ChIP-Seq_HELA_Human1.37738955
53FOXM1_26456572_ChIP-Seq_MCF-7_Human1.36707967
54FOXA1_21572438_ChIP-Seq_LNCaP_Human1.36527986
55SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.34181604
56FOXO3_23340844_ChIP-Seq_DLD1_Human1.32928887
57CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.30204199
58NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.29417566
59FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.28954454
60NR3C1_21868756_ChIP-Seq_MCF10A_Human1.27888669
61AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.27343997
62ESR1_20079471_ChIP-ChIP_T-47D_Human1.24955240
63NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.23795663
64PHF8_20622853_ChIP-Seq_HELA_Human1.23607490
65PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.23371728
66RBPJ_21746931_ChIP-Seq_IB4_Human1.22972356
67NCOR_22424771_ChIP-Seq_293T_Human1.21140425
68RUNX1_27514584_Chip-Seq_MCF-7_Human1.19515349
69GATA3_21878914_ChIP-Seq_MCF-7_Human1.19289981
70PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.17672892
71HNFA_21074721_ChIP-Seq_CACO-2_Human1.16929845
72ERG_20517297_ChIP-Seq_VCAP_Human1.15096213
73KAP1_22055183_ChIP-Seq_ESCs_Mouse1.15000335
74PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.13999330
75ARNT_22903824_ChIP-Seq_MCF-7_Human1.13687395
76EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.13045888
77TCF4_22108803_ChIP-Seq_LS180_Human1.11579090
78PIAS1_25552417_ChIP-Seq_VCAP_Human1.11106782
79GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.10301759
80CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.09926097
81HOXB7_26014856_ChIP-Seq_BT474_Human1.08125611
82ETV1_20927104_ChIP-Seq_GIST48_Human1.07366170
83GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.06991555
84RACK7_27058665_Chip-Seq_MCF-7_Human1.06785240
85ER_23166858_ChIP-Seq_MCF-7_Human1.06710351
86ESR2_21235772_ChIP-Seq_MCF-7_Human1.06145922
87FOXA1_25329375_ChIP-Seq_VCAP_Human1.05592444
88FOXA1_27270436_Chip-Seq_PROSTATE_Human1.05592444
89TAF2_19829295_ChIP-Seq_ESCs_Human1.05488007
90CDX2_19796622_ChIP-Seq_MESCs_Mouse1.05152298
91GATA6_21074721_ChIP-Seq_CACO-2_Human1.04957173
92POU3F2_20337985_ChIP-ChIP_501MEL_Human1.04952077
93SALL4_18804426_ChIP-ChIP_XEN_Mouse1.04524530
94TP53_22573176_ChIP-Seq_HFKS_Human1.04512918
95EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.03406423
96E2F1_18555785_ChIP-Seq_MESCs_Mouse1.02632905
97POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.02351136
98TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.01591729
99PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.00848771
100P53_21459846_ChIP-Seq_SAOS-2_Human1.00270524
101SOX2_19829295_ChIP-Seq_ESCs_Human1.00187587
102NANOG_19829295_ChIP-Seq_ESCs_Human1.00187587
103CEBPB_22108803_ChIP-Seq_LS180_Human0.99873314
104RARB_24833708_ChIP-Seq_LIVER_Mouse0.99826437
105TET1_21451524_ChIP-Seq_MESCs_Mouse0.99202368
106FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.99124284
107RARA_24833708_ChIP-Seq_LIVER_Mouse0.99093026
108KLF5_25053715_ChIP-Seq_YYC3_Human0.98714205
109KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.98264546
110HNF4A_19822575_ChIP-Seq_HepG2_Human0.98108287
111EST1_17652178_ChIP-ChIP_JURKAT_Human0.98042969
112EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.97834880
113FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.97494272
114HTT_18923047_ChIP-ChIP_STHdh_Human0.97162411
115ERA_21632823_ChIP-Seq_H3396_Human0.96824792
116AR_20517297_ChIP-Seq_VCAP_Human0.96357857
117NFYA_21822215_ChIP-Seq_K562_Human0.96110037
118MYC_19829295_ChIP-Seq_ESCs_Human0.95099188
119BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.94700876
120TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.94399011
121SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.94130840
122NANOG_18555785_ChIP-Seq_MESCs_Mouse0.93961810
123AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93786828
124P63_26484246_Chip-Seq_KERATINOCYTES_Human0.93470406
125ELF5_23300383_ChIP-Seq_T47D_Human0.92974228
126AR_25329375_ChIP-Seq_VCAP_Human0.92048155
127NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.91905553
128CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.91712384
129P300_27268052_Chip-Seq_Bcells_Human0.91687944
130CTBP1_25329375_ChIP-Seq_LNCAP_Human0.91637678
131NANOG_20526341_ChIP-Seq_ESCs_Human0.90232017
132ATF3_27146783_Chip-Seq_COLON_Human0.89977428
133CBX2_22325352_ChIP-Seq_293T-Rex_Human0.89474654
134KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.89245272
135NFYB_21822215_ChIP-Seq_K562_Human0.89005905
136OCT4_18692474_ChIP-Seq_MEFs_Mouse0.87700730
137SOX17_20123909_ChIP-Seq_XEN_Mouse0.87154639
138GATA1_22025678_ChIP-Seq_K562_Human0.86118193
139PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.84150640
140ETS1_20019798_ChIP-Seq_JURKAT_Human0.81730797
141SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.81402858
142RARG_19884340_ChIP-ChIP_MEFs_Mouse0.80464182
143CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.80076075
144GATA3_21867929_ChIP-Seq_CD8_Mouse0.79337510
145ETV2_25802403_ChIP-Seq_MESCs_Mouse0.79106055
146RAD21_21589869_ChIP-Seq_MESCs_Mouse0.78936722
147GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.78341305
148SOX2_22085726_ChIP-Seq_NPCs_Mouse0.78335945
149CHD1_26751641_Chip-Seq_LNCaP_Human0.78203248
150TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.77180654
151CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.76761324
152TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.75964056
153ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.75196046
154ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.73574551

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003283_abnormal_digestive_organ5.93956416
2MP0010234_abnormal_vibrissa_follicle4.52984825
3MP0004043_abnormal_pH_regulation3.60165182
4MP0004264_abnormal_extraembryonic_tissu3.42553721
5MP0000462_abnormal_digestive_system3.31521552
6MP0001666_abnormal_nutrient_absorption3.08743579
7MP0002139_abnormal_hepatobiliary_system2.94259003
8MP0005360_urolithiasis2.79982575
9MP0010386_abnormal_urinary_bladder2.76209032
10MP0003195_calcinosis2.54075837
11MP0000013_abnormal_adipose_tissue2.44413298
12MP0005085_abnormal_gallbladder_physiolo2.37533512
13MP0001944_abnormal_pancreas_morphology2.31343174
14MP0004019_abnormal_vitamin_homeostasis2.26935115
15MP0005365_abnormal_bile_salt2.25720743
16MP0003183_abnormal_peptide_metabolism2.24028825
17MP0008875_abnormal_xenobiotic_pharmacok2.21836353
18MP0002693_abnormal_pancreas_physiology2.21137048
19MP0005220_abnormal_exocrine_pancreas2.20489781
20MP0000678_abnormal_parathyroid_gland2.17952452
21MP0005379_endocrine/exocrine_gland_phen2.13873408
22MP0000613_abnormal_salivary_gland2.06616593
23MP0009643_abnormal_urine_homeostasis2.06588083
24MP0005377_hearing/vestibular/ear_phenot2.00655633
25MP0003878_abnormal_ear_physiology2.00655633
26MP0002138_abnormal_hepatobiliary_system1.96541052
27MP0003252_abnormal_bile_duct1.94582129
28MP0003866_abnormal_defecation1.90581480
29MP0004147_increased_porphyrin_level1.87640035
30MP0002877_abnormal_melanocyte_morpholog1.84973232
31MP0002909_abnormal_adrenal_gland1.84544744
32MP0001756_abnormal_urination1.82447306
33MP0001765_abnormal_ion_homeostasis1.76731719
34MP0008004_abnormal_stomach_pH1.76079122
35MP0005084_abnormal_gallbladder_morpholo1.74166370
36MP0008872_abnormal_physiological_respon1.70191814
37MP0003315_abnormal_perineum_morphology1.69702019
38MP0003300_gastrointestinal_ulcer1.69574675
39MP0009780_abnormal_chondrocyte_physiolo1.68494026
40MP0002234_abnormal_pharynx_morphology1.68392441
41MP0005636_abnormal_mineral_homeostasis1.67830498
42MP0002098_abnormal_vibrissa_morphology1.61451490
43MP0002653_abnormal_ependyma_morphology1.61206101
44MP0001664_abnormal_digestion1.56513898
45MP0000538_abnormal_urinary_bladder1.51805597
46MP0002822_catalepsy1.49407351
47MP0003806_abnormal_nucleotide_metabolis1.48074723
48MP0010352_gastrointestinal_tract_polyps1.40081518
49MP0005646_abnormal_pituitary_gland1.39619408
50MP0006072_abnormal_retinal_apoptosis1.37059069
51MP0005058_abnormal_lysosome_morphology1.29246605
52MP0002638_abnormal_pupillary_reflex1.25760201
53MP0000003_abnormal_adipose_tissue1.24760023
54MP0003868_abnormal_feces_composition1.24411358
55MP0001501_abnormal_sleep_pattern1.24188345
56MP0002078_abnormal_glucose_homeostasis1.23324219
57MP0000477_abnormal_intestine_morphology1.20435622
58MP0002163_abnormal_gland_morphology1.19601101
59MP0006036_abnormal_mitochondrial_physio1.19336419
60MP0005332_abnormal_amino_acid1.18632876
61MP0003787_abnormal_imprinting1.18154148
62MP0001986_abnormal_taste_sensitivity1.15919522
63MP0005381_digestive/alimentary_phenotyp1.15151388
64MP0002928_abnormal_bile_duct1.14640293
65MP0000427_abnormal_hair_cycle1.14548912
66MP0005645_abnormal_hypothalamus_physiol1.14023858
67MP0004782_abnormal_surfactant_physiolog1.13773846
68MP0002876_abnormal_thyroid_physiology1.12485788
69MP0002837_dystrophic_cardiac_calcinosis1.12336430
70MP0005408_hypopigmentation1.11035050
71MP0000383_abnormal_hair_follicle1.09263306
72MP0002277_abnormal_respiratory_mucosa1.07661726
73MP0004133_heterotaxia1.06754641
74MP0005310_abnormal_salivary_gland1.05801539
75MP0009379_abnormal_foot_pigmentation1.00067287
76MP0003953_abnormal_hormone_level0.97851928
77MP0005319_abnormal_enzyme/_coenzyme0.97002854
78MP0000490_abnormal_crypts_of0.95041269
79MP0001764_abnormal_homeostasis0.94138135
80MP0002896_abnormal_bone_mineralization0.91674000
81MP0005535_abnormal_body_temperature0.91480029
82MP0001984_abnormal_olfaction0.91370729
83MP0002166_altered_tumor_susceptibility0.90749927
84MP0001905_abnormal_dopamine_level0.90598111
85MP0005551_abnormal_eye_electrophysiolog0.89890512
86MP0003011_delayed_dark_adaptation0.88913872
87MP0010155_abnormal_intestine_physiology0.88332920
88MP0002118_abnormal_lipid_homeostasis0.86727615
89MP0005367_renal/urinary_system_phenotyp0.85995556
90MP0000516_abnormal_urinary_system0.85995556
91MP0009053_abnormal_anal_canal0.84242654
92MP0004270_analgesia0.82575839
93MP0010329_abnormal_lipoprotein_level0.82326152
94MP0003638_abnormal_response/metabolism_0.82181780
95MP0002938_white_spotting0.81629014
96MP0003119_abnormal_digestive_system0.81188958
97MP0005166_decreased_susceptibility_to0.80805268
98MP0003693_abnormal_embryo_hatching0.80443730
99MP0001881_abnormal_mammary_gland0.78938934
100MP0009642_abnormal_blood_homeostasis0.76478444
101MP0005257_abnormal_intraocular_pressure0.76274798
102MP0003186_abnormal_redox_activity0.76169825
103MP0003959_abnormal_lean_body0.76051219
104MP0005075_abnormal_melanosome_morpholog0.75407291
105MP0000470_abnormal_stomach_morphology0.74931682
106MP0001873_stomach_inflammation0.74277061
107MP0000230_abnormal_systemic_arterial0.74237185
108MP0005174_abnormal_tail_pigmentation0.73779901
109MP0000537_abnormal_urethra_morphology0.72355532
110MP0001485_abnormal_pinna_reflex0.71826423
111MP0000609_abnormal_liver_physiology0.71773813
112MP0002136_abnormal_kidney_physiology0.71070137
113MP0009840_abnormal_foam_cell0.70694841
114MP0002160_abnormal_reproductive_system0.70314278
115MP0002796_impaired_skin_barrier0.69705139
116MP0005165_increased_susceptibility_to0.69283905
117MP0005083_abnormal_biliary_tract0.68934710
118MP0001663_abnormal_digestive_system0.68600665
119MP0005584_abnormal_enzyme/coenzyme_acti0.68061327
120MP0000762_abnormal_tongue_morphology0.67885054
121MP0003718_maternal_effect0.67108190
122MP0008789_abnormal_olfactory_epithelium0.66672336
123MP0003941_abnormal_skin_development0.65060924
124MP0002254_reproductive_system_inflammat0.62474338
125MP0005448_abnormal_energy_balance0.61941008
126MP0002132_abnormal_respiratory_system0.61359681
127MP0010678_abnormal_skin_adnexa0.60356677
128MP0005395_other_phenotype0.59969212
129MP0003879_abnormal_hair_cell0.59767354
130MP0002751_abnormal_autonomic_nervous0.56807107
131MP0005375_adipose_tissue_phenotype0.56261070

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.73950962
2Abnormal respiratory epithelium morphology (HP:0012253)5.17375089
3Abnormal respiratory motile cilium morphology (HP:0005938)5.17375089
4Abnormal respiratory motile cilium physiology (HP:0012261)5.00324022
5Abnormal ciliary motility (HP:0012262)4.89449432
6Rhinitis (HP:0012384)4.88675510
7Absent/shortened dynein arms (HP:0200106)4.81663336
8Dynein arm defect of respiratory motile cilia (HP:0012255)4.81663336
9Hypoglycemic coma (HP:0001325)4.54667705
10Hypoglycemic seizures (HP:0002173)4.48657942
11Hyperinsulinemic hypoglycemia (HP:0000825)4.43110596
12Symptomatic seizures (HP:0011145)4.39493000
13Bronchiectasis (HP:0002110)4.12314559
14Hyperactive renin-angiotensin system (HP:0000841)4.09790787
15Flat capital femoral epiphysis (HP:0003370)3.82274646
16Posterior subcapsular cataract (HP:0007787)3.59998155
17Abnormality of chloride homeostasis (HP:0011422)3.57541564
18Flat acetabular roof (HP:0003180)3.50216763
19Hyperglycemia (HP:0003074)3.45702270
20Abdominal distention (HP:0003270)3.39095182
21Glycosuria (HP:0003076)3.35448646
22Abnormality of urine glucose concentration (HP:0011016)3.35448646
23Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.31630784
24Late onset (HP:0003584)3.29337895
25Abnormality of glutamine family amino acid metabolism (HP:0010902)3.27670432
26Nasal polyposis (HP:0100582)3.22077566
27Decreased circulating renin level (HP:0003351)3.21743559
28Abnormality of vitamin B metabolism (HP:0004340)3.17256497
29Abnormal pancreas size (HP:0012094)3.16930625
30Symphalangism affecting the phalanges of the hand (HP:0009773)3.14684326
31Conjugated hyperbilirubinemia (HP:0002908)3.10222054
32Hyperphosphaturia (HP:0003109)3.07185739
33Abnormality of aromatic amino acid family metabolism (HP:0004338)3.06498603
34Abnormal tarsal ossification (HP:0008369)3.05204800
35Gout (HP:0001997)3.03528844
36Abnormality of carpal bone ossification (HP:0006257)2.93043029
37Abnormality of the 1st metacarpal (HP:0010009)2.89562691
38Ketoacidosis (HP:0001993)2.84387181
39Lipid accumulation in hepatocytes (HP:0006561)2.83901649
40True hermaphroditism (HP:0010459)2.79722958
41Malnutrition (HP:0004395)2.79546047
42Abnormality of vitamin metabolism (HP:0100508)2.78121978
43Abnormality of the nasal mucosa (HP:0000433)2.76188686
44Abnormality of renin-angiotensin system (HP:0000847)2.76000029
45Pancreatic fibrosis (HP:0100732)2.74791135
46Pancreatic cysts (HP:0001737)2.74504143
47Abnormal biliary tract morphology (HP:0012440)2.70960878
48Increased hepatocellular lipid droplets (HP:0006565)2.64699090
49Chronic sinusitis (HP:0011109)2.62755790
50Congenital sensorineural hearing impairment (HP:0008527)2.61350406
51Hypokalemia (HP:0002900)2.60666770
52Cupped ribs (HP:0000887)2.58800714
53Vascular calcification (HP:0004934)2.56482439
54Generalized aminoaciduria (HP:0002909)2.56411069
55Bronchitis (HP:0012387)2.56299116
56Abnormal urine phosphate concentration (HP:0012599)2.54139947
57Fat malabsorption (HP:0002630)2.53322238
58Ileus (HP:0002595)2.50175247
59Abnormality of calcium-phosphate metabolism (HP:0100530)2.49877592
60Insulin-resistant diabetes mellitus (HP:0000831)2.45319148
61Spinal cord compression (HP:0002176)2.45302976
62Metabolic alkalosis (HP:0200114)2.45133490
63Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.44056605
64Vacuolated lymphocytes (HP:0001922)2.42513976
65Abnormality of the renal cortex (HP:0011035)2.41660844
66Dysostosis multiplex (HP:0000943)2.41032439
67Abnormality of renal resorption (HP:0011038)2.40494510
68Tubular atrophy (HP:0000092)2.39170568
69Abnormality of the vitamin B12 metabolism (HP:0004341)2.37938156
70Renal salt wasting (HP:0000127)2.37733818
71Large for gestational age (HP:0001520)2.37012318
72Villous atrophy (HP:0011473)2.36775565
73Abnormality of small intestinal villus morphology (HP:0011472)2.36775565
74Hyperaldosteronism (HP:0000859)2.36266836
75Steatorrhea (HP:0002570)2.35145455
76Renal Fanconi syndrome (HP:0001994)2.31895643
77Abnormality of the distal phalanx of the thumb (HP:0009617)2.31131576
78Nephronophthisis (HP:0000090)2.28256522
79Right ventricular cardiomyopathy (HP:0011663)2.27922258
80Abnormality of proline metabolism (HP:0010907)2.27194708
81Hydroxyprolinuria (HP:0003080)2.27194708
82Flattened epiphyses (HP:0003071)2.27187345
83Hyperglycinuria (HP:0003108)2.26365891
84Tubulointerstitial nephritis (HP:0001970)2.24759780
85Ketosis (HP:0001946)2.24413763
86Osteomalacia (HP:0002749)2.24068689
87Proximal tubulopathy (HP:0000114)2.23911133
88Vertebral clefting (HP:0008428)2.23000783
89Acute necrotizing encephalopathy (HP:0006965)2.21207484
90Vertebral hypoplasia (HP:0008417)2.20745253
91Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.20745253
92Neonatal short-limb short stature (HP:0008921)2.20570079
93Dicarboxylic aciduria (HP:0003215)2.20502025
94Abnormality of dicarboxylic acid metabolism (HP:0010995)2.20502025
95Abnormality of endocrine pancreas physiology (HP:0012093)2.20362382
96Abnormality of the pancreatic islet cells (HP:0006476)2.20362382
97Aplasia/hypoplasia of the uterus (HP:0008684)2.20111533
98Furrowed tongue (HP:0000221)2.20111001
99Hyperparathyroidism (HP:0000843)2.20069278
100Cystic liver disease (HP:0006706)2.19753529
101Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.19640943
102Hypothermia (HP:0002045)2.19513129
103Chronic bronchitis (HP:0004469)2.19459603
104Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.18970194
105Mucopolysacchariduria (HP:0008155)2.17307634
106Urinary glycosaminoglycan excretion (HP:0003541)2.17307634
107Abnormal cartilage morphology (HP:0002763)2.17300539
108Abnormal hand bone ossification (HP:0010660)2.16544006
109Abnormal hemoglobin (HP:0011902)2.16329482
110Flared iliac wings (HP:0002869)2.15587700
111Hepatic necrosis (HP:0002605)2.15174512
112Occipital encephalocele (HP:0002085)2.15095315
113Alkalosis (HP:0001948)2.14734507
114Progressive macrocephaly (HP:0004481)2.14070849
115Mitochondrial inheritance (HP:0001427)2.13690148
116Abnormality of midbrain morphology (HP:0002418)2.13655083
117Molar tooth sign on MRI (HP:0002419)2.13655083
118Acute encephalopathy (HP:0006846)2.13576109
119Recurrent sinusitis (HP:0011108)2.13083131
120Abnormality of the renal medulla (HP:0100957)2.12958090
121Abnormality of potassium homeostasis (HP:0011042)2.12934535
122Infertility (HP:0000789)2.11665680
123Cardiovascular calcification (HP:0011915)2.08928102
124Hepatocellular necrosis (HP:0001404)2.08816819
125Abnormal mitochondria in muscle tissue (HP:0008316)2.08526119
126Abnormal foot bone ossification (HP:0010675)2.08199101
127Abnormality of the proximal phalanges of the hand (HP:0009834)2.06988664
128Exertional dyspnea (HP:0002875)2.06649029
129Insulin resistance (HP:0000855)2.05888585
130Increased muscle lipid content (HP:0009058)2.05347988
131Increased CSF lactate (HP:0002490)2.04745855
132Abnormality of purine metabolism (HP:0004352)2.04010853
133Abnormality of polysaccharide metabolism (HP:0011012)2.03540333
134Abnormality of glycosaminoglycan metabolism (HP:0004371)2.03540333
135Abnormality of mucopolysaccharide metabolism (HP:0011020)2.03540333
136Lethargy (HP:0001254)2.01320557
137Shawl scrotum (HP:0000049)2.01261616
138Hyperkalemia (HP:0002153)2.01255283
139Hypokinesia (HP:0002375)2.01219405
140Hypokalemic alkalosis (HP:0001949)2.00665878
141Hyperphosphatemia (HP:0002905)2.00388792
142Type I transferrin isoform profile (HP:0003642)2.00003773
143Exocrine pancreatic insufficiency (HP:0001738)1.99196641
144Abnormal albumin level (HP:0012116)1.98795406
145Hypoalbuminemia (HP:0003073)1.98795406
146Cheilitis (HP:0100825)1.96672022
147Hypoplasia of the uterus (HP:0000013)1.95998571
148Hyponatremia (HP:0002902)1.95564522
149Abnormal protein glycosylation (HP:0012346)1.95240471
150Abnormal glycosylation (HP:0012345)1.95240471
151Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.95240471
152Abnormal protein N-linked glycosylation (HP:0012347)1.95240471
153Increased intramyocellular lipid droplets (HP:0012240)1.95059133
154Metabolic acidosis (HP:0001942)1.93958189
155Biliary tract neoplasm (HP:0100574)1.92396244
156Methylmalonic aciduria (HP:0012120)1.88643112
157Medial flaring of the eyebrow (HP:0010747)1.87822607
158Hypotension (HP:0002615)1.87095055
159Abnormality of renal excretion (HP:0011036)1.85872733
160Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.84832236
161Decreased activity of mitochondrial respiratory chain (HP:0008972)1.84832236
162Abnormality of magnesium homeostasis (HP:0004921)1.84369745
163Male pseudohermaphroditism (HP:0000037)1.82032534
164Popliteal pterygium (HP:0009756)1.79692539
165Cerebral edema (HP:0002181)1.78147976
166Tongue fasciculations (HP:0001308)1.75385815
167Male infertility (HP:0003251)1.74955450

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK38.93668652
2MAPK154.01810055
3FRK3.49862441
4MAP3K123.36432429
5EPHB23.24080960
6EPHA23.04773750
7INSRR2.88424034
8ACVR1B2.85196994
9WNK42.84706022
10MAP2K22.58061978
11MST1R2.47668175
12WNK32.36405803
13NME12.33435345
14PASK2.27847079
15STK38L2.17245192
16OXSR12.11705231
17MAP3K22.08863687
18PIK3CG2.06586040
19STK241.96242238
20LMTK21.84108093
21MAP4K21.80037927
22NUAK11.77159390
23STK161.75195895
24PHKG21.69101012
25PHKG11.69101012
26MST41.66858110
27IRAK31.66039421
28PIK3CA1.63079242
29MAPKAPK31.62966945
30AKT31.55579069
31ARAF1.48589675
32HIPK21.31815741
33PINK11.31707582
34ZAK1.28908411
35MET1.25113924
36PTK61.20634972
37BRAF1.20616956
38BCKDK1.19951461
39PRKG21.18810347
40MUSK1.15421789
41PRKCI1.14422047
42PBK1.11796235
43DAPK21.07631217
44CASK1.06920315
45PTK21.02402219
46RIPK11.01122736
47FGFR20.96773382
48TTK0.96137786
49MAP3K30.84454390
50TESK10.83980655
51EPHA30.82321318
52NLK0.79058997
53STK30.78604602
54ERN10.78033595
55ERBB30.77468857
56DYRK1B0.75707758
57LIMK10.74711756
58PTK2B0.74685161
59CAMK2D0.72627832
60TRIM280.72535359
61FGFR30.71843249
62TEC0.71735068
63CSNK1G30.69451207
64CSNK1G10.69345522
65BMPR20.67913686
66TNIK0.67754102
67MAP2K10.65292208
68PRKD30.65209440
69MAP3K10.62997035
70STK390.62092848
71CDC42BPA0.61234613
72EIF2AK10.60785327
73TLK10.59589567
74TAOK10.57363697
75PAK40.56716169
76ADRBK10.54664128
77ERBB20.53746772
78ABL20.53337193
79TBK10.52935506
80IRAK10.52503982
81DAPK10.51677149
82MAP3K40.51604352
83EPHB10.51133660
84FLT30.50469809
85PRKD20.50299785
86VRK20.50172865
87ADRBK20.49654798
88CSNK1G20.49252443
89FER0.47580236
90GRK10.47276476
91PRKCQ0.47164114
92CAMK2G0.46300093
93EIF2AK30.45715796
94PIM20.45130161
95AURKB0.43812229
96LRRK20.43532850
97CAMK2B0.42796918
98TNK20.42163100
99PAK30.40050454
100RPS6KB20.39433656
101TRPM70.39297505
102NTRK30.38778132
103IKBKB0.37004012
104MYLK0.35221053
105TYK20.34721488
106MAP3K70.34554906
107MAP2K60.33904587
108PRKCE0.33773037
109IKBKE0.33342731
110STK380.32821031
111WNK10.31922953
112BMPR1B0.31175849
113MAP3K110.31066949
114ILK0.30734127
115CSNK1A10.29348427
116PRKCZ0.29310487
117CAMK2A0.28950111
118ROCK10.28902724
119PRKCA0.26113979
120PRKAA20.23612712
121DYRK20.21910178
122IRAK20.21519044
123DYRK30.20916908
124LATS10.20846973
125PRKAA10.19992773
126CHUK0.19868571
127KSR20.18449914
128ITK0.18004457
129NEK60.16168397
130CAMKK20.15868813
131PAK10.15565366
132PLK10.15360533
133VRK10.15053952
134GSK3A0.13963744
135MAPKAPK20.12845548
136GRK60.12829287
137BRSK20.12211270
138RPS6KA50.11046787
139CSNK2A10.09992874
140PRKACA0.08860717
141ERBB40.08476409
142MAP3K140.08455099
143PRKACG0.08303460

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049506.76720172
2Sulfur metabolism_Homo sapiens_hsa009205.86847525
3Protein export_Homo sapiens_hsa030603.67275494
4Cyanoamino acid metabolism_Homo sapiens_hsa004602.60391719
5Folate biosynthesis_Homo sapiens_hsa007902.37033432
6Pentose and glucuronate interconversions_Homo sapiens_hsa000402.33404397
7Oxidative phosphorylation_Homo sapiens_hsa001902.29807851
8Fat digestion and absorption_Homo sapiens_hsa049752.27755664
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.16919736
10Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.10227963
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.88660566
12Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.88577725
13Galactose metabolism_Homo sapiens_hsa000521.81083847
14Sulfur relay system_Homo sapiens_hsa041221.78821524
15Mineral absorption_Homo sapiens_hsa049781.75698883
16Parkinsons disease_Homo sapiens_hsa050121.70040893
17Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.60811461
18Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.58361750
19Fructose and mannose metabolism_Homo sapiens_hsa000511.58322745
20Linoleic acid metabolism_Homo sapiens_hsa005911.56368905
21Selenocompound metabolism_Homo sapiens_hsa004501.54463370
22Butanoate metabolism_Homo sapiens_hsa006501.53824994
23Drug metabolism - other enzymes_Homo sapiens_hsa009831.53491516
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.53166010
25Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.52830272
26Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.50328574
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.49009496
28Other glycan degradation_Homo sapiens_hsa005111.48090699
29Arginine biosynthesis_Homo sapiens_hsa002201.46173126
30Histidine metabolism_Homo sapiens_hsa003401.45336414
31Starch and sucrose metabolism_Homo sapiens_hsa005001.42312745
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.41291169
33Vibrio cholerae infection_Homo sapiens_hsa051101.39358325
34Tryptophan metabolism_Homo sapiens_hsa003801.35555821
35Alzheimers disease_Homo sapiens_hsa050101.34223438
36Insulin secretion_Homo sapiens_hsa049111.33910269
37Nitrogen metabolism_Homo sapiens_hsa009101.31938276
38Chemical carcinogenesis_Homo sapiens_hsa052041.30041380
39Glutathione metabolism_Homo sapiens_hsa004801.22002641
40Huntingtons disease_Homo sapiens_hsa050161.21406836
41Carbohydrate digestion and absorption_Homo sapiens_hsa049731.19220054
42Steroid hormone biosynthesis_Homo sapiens_hsa001401.13468702
43Regulation of autophagy_Homo sapiens_hsa041401.12638916
44Arachidonic acid metabolism_Homo sapiens_hsa005901.10607182
45Fatty acid degradation_Homo sapiens_hsa000711.04054452
46Pancreatic secretion_Homo sapiens_hsa049720.99306876
47Renin-angiotensin system_Homo sapiens_hsa046140.97417495
48N-Glycan biosynthesis_Homo sapiens_hsa005100.96078531
49Vitamin B6 metabolism_Homo sapiens_hsa007500.93223923
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.87848661
51Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.85342198
52Primary bile acid biosynthesis_Homo sapiens_hsa001200.83600282
53RNA polymerase_Homo sapiens_hsa030200.82916461
54Retinol metabolism_Homo sapiens_hsa008300.82122045
55Vitamin digestion and absorption_Homo sapiens_hsa049770.80906200
56Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.79247884
57Peroxisome_Homo sapiens_hsa041460.79194366
58Protein digestion and absorption_Homo sapiens_hsa049740.77444053
59ABC transporters_Homo sapiens_hsa020100.77205219
60Arginine and proline metabolism_Homo sapiens_hsa003300.74156888
61Metabolic pathways_Homo sapiens_hsa011000.73855296
62Asthma_Homo sapiens_hsa053100.71768275
63Phenylalanine metabolism_Homo sapiens_hsa003600.71527805
64Glycosaminoglycan degradation_Homo sapiens_hsa005310.70693516
65Phototransduction_Homo sapiens_hsa047440.68793439
66Intestinal immune network for IgA production_Homo sapiens_hsa046720.68097113
67Propanoate metabolism_Homo sapiens_hsa006400.66955533
68Pentose phosphate pathway_Homo sapiens_hsa000300.66689075
69Ribosome_Homo sapiens_hsa030100.66221760
70Bile secretion_Homo sapiens_hsa049760.65569656
71Glycerophospholipid metabolism_Homo sapiens_hsa005640.63888558
72Tyrosine metabolism_Homo sapiens_hsa003500.63583426
73Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.62832903
74Caffeine metabolism_Homo sapiens_hsa002320.62751153
75Sphingolipid metabolism_Homo sapiens_hsa006000.62310708
76Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.58947667
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.58749633
78Lysosome_Homo sapiens_hsa041420.58587711
79beta-Alanine metabolism_Homo sapiens_hsa004100.58155488
80Circadian rhythm_Homo sapiens_hsa047100.57891831
81Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.54814691
82Tight junction_Homo sapiens_hsa045300.52505463
83Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52032900
84Pyrimidine metabolism_Homo sapiens_hsa002400.50771784
85Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.49813746
86Thyroid hormone synthesis_Homo sapiens_hsa049180.49721749
87Glycerolipid metabolism_Homo sapiens_hsa005610.49512355
88Pyruvate metabolism_Homo sapiens_hsa006200.48989918
89Ether lipid metabolism_Homo sapiens_hsa005650.47401844
90Type II diabetes mellitus_Homo sapiens_hsa049300.45219560
91Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41846703
92Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.41455167
93Steroid biosynthesis_Homo sapiens_hsa001000.40576091
94Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39493743
95Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38516456
96Ovarian steroidogenesis_Homo sapiens_hsa049130.33806613
97Renin secretion_Homo sapiens_hsa049240.32874808
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.32841290
99Salivary secretion_Homo sapiens_hsa049700.32382983
100Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.31067741
101SNARE interactions in vesicular transport_Homo sapiens_hsa041300.30357865
102Fatty acid metabolism_Homo sapiens_hsa012120.29563263
103Collecting duct acid secretion_Homo sapiens_hsa049660.29529499
104Purine metabolism_Homo sapiens_hsa002300.29049977
105PPAR signaling pathway_Homo sapiens_hsa033200.28770613
106Fatty acid elongation_Homo sapiens_hsa000620.27286596
107Carbon metabolism_Homo sapiens_hsa012000.25649183
108Cardiac muscle contraction_Homo sapiens_hsa042600.24477857
109Cocaine addiction_Homo sapiens_hsa050300.24063602
110Taste transduction_Homo sapiens_hsa047420.23760437
111Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.23708066
112Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.21277066
113Rheumatoid arthritis_Homo sapiens_hsa053230.17804073
114Proteasome_Homo sapiens_hsa030500.16692759
115Thyroid cancer_Homo sapiens_hsa052160.16614375
116Serotonergic synapse_Homo sapiens_hsa047260.16601810
117Hepatitis C_Homo sapiens_hsa051600.14647586
118Type I diabetes mellitus_Homo sapiens_hsa049400.13523407

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