ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	spermatid development (GO:0007286)	9.92344742
2	axonemal dynein complex assembly (GO:0070286)	9.81674814
3	reproduction (GO:0000003)	9.39390326
4	motile cilium assembly (GO:0044458)	9.17030020
5	regulation of cilium movement (GO:0003352)	8.75202195
6	cilium or flagellum-dependent cell motility (GO:0001539)	8.50211585
7	cilium movement (GO:0003341)	8.07761413
8	single fertilization (GO:0007338)	7.40033204
9	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	7.35756642
10	sperm capacitation (GO:0048240)	7.24462102
11	negative regulation of inclusion body assembly (GO:0090084)	7.17045795
12	synaptonemal complex organization (GO:0070193)	6.93942780
13	spermatogenesis (GO:0007283)	6.87497039
14	male gamete generation (GO:0048232)	6.84965480
15	synaptonemal complex assembly (GO:0007130)	6.82507109
16	organic cation transport (GO:0015695)	6.72193064
17	male meiosis (GO:0007140)	6.69444238
18	microtubule depolymerization (GO:0007019)	6.46468737
19	piRNA metabolic process (GO:0034587)	6.41710366
20	fertilization (GO:0009566)	6.30618161
21	gamete generation (GO:0007276)	6.29738390
22	regulation of inclusion body assembly (GO:0090083)	6.06511021
23	calcium ion-dependent exocytosis (GO:0017156)	5.70942582
24	germ cell development (GO:0007281)	5.50198390
25	chromosome condensation (GO:0030261)	5.43392075
26	cellular process involved in reproduction in multicellular organism (GO:0022412)	5.42746387
27	glycerol ether metabolic process (GO:0006662)	5.40087572
28	spermatid nucleus differentiation (GO:0007289)	5.37900399
29	regulation of microtubule-based movement (GO:0060632)	5.23734948
30	ventricular system development (GO:0021591)	5.21181295
31	DNA packaging (GO:0006323)	5.13674040
32	cell recognition (GO:0008037)	5.06116194
33	ether metabolic process (GO:0018904)	4.99285056
34	multicellular organismal reproductive process (GO:0048609)	4.95907424
35	sexual reproduction (GO:0019953)	4.81307620
36	microtubule severing (GO:0051013)	4.64813030
37	male meiosis I (GO:0007141)	4.64784386
38	chromosome organization involved in meiosis (GO:0070192)	4.61748953
39	seminiferous tubule development (GO:0072520)	4.57160060
40	single strand break repair (GO:0000012)	4.53804623
41	left/right pattern formation (GO:0060972)	4.30042980
42	DNA methylation involved in gamete generation (GO:0043046)	4.20187534
43	chaperone-mediated protein complex assembly (GO:0051131)	4.16111937
44	sequestering of actin monomers (GO:0042989)	4.12182556
45	meiotic nuclear division (GO:0007126)	4.04109714
46	multicellular organismal development (GO:0007275)	3.96634181
47	genitalia morphogenesis (GO:0035112)	3.78312513
48	meiosis I (GO:0007127)	3.69605766
49	protein K11-linked deubiquitination (GO:0035871)	3.60847932
50	protein polyglutamylation (GO:0018095)	3.46009217
51	microtubule polymerization or depolymerization (GO:0031109)	3.35843528
52	regulation of spindle checkpoint (GO:0090231)	3.30383690
53	glycolytic process (GO:0006096)	3.29877600
54	protein refolding (GO:0042026)	3.29461388
55	monoubiquitinated protein deubiquitination (GO:0035520)	3.22020430
56	meiotic cell cycle (GO:0051321)	3.16653308
57	nucleus organization (GO:0006997)	3.12560582
58	nucleoside diphosphate phosphorylation (GO:0006165)	3.08670655
59	protein localization to cilium (GO:0061512)	3.05565546
60	amino-acid betaine transport (GO:0015838)	3.04418524
61	carnitine transport (GO:0015879)	3.04418524
62	positive regulation of macrophage activation (GO:0043032)	3.02575830
63	interferon-gamma secretion (GO:0072643)	2.98626605
64	RNA localization (GO:0006403)	2.95745968
65	GTP biosynthetic process (GO:0006183)	2.95397936
66	polyol catabolic process (GO:0046174)	2.93662985
67	polyamine biosynthetic process (GO:0006596)	2.90607371
68	carnitine transmembrane transport (GO:1902603)	2.85944809
69	RNA destabilization (GO:0050779)	2.83903330
70	alditol metabolic process (GO:0019400)	2.82605133
71	mitotic sister chromatid cohesion (GO:0007064)	2.80807880
72	chromatin silencing (GO:0006342)	2.80503302
73	cilium organization (GO:0044782)	2.72162905
74	meiotic cell cycle process (GO:1903046)	2.71101416
75	microtubule-based movement (GO:0007018)	2.69475701
76	synapsis (GO:0007129)	2.68252731
77	regulation of cilium assembly (GO:1902017)	2.67432284
78	lactate metabolic process (GO:0006089)	2.66329908
79	UTP biosynthetic process (GO:0006228)	2.63699835
80	cellular component assembly involved in morphogenesis (GO:0010927)	2.61156455
81	cilium assembly (GO:0042384)	2.60901307
82	intraciliary transport (GO:0042073)	2.59372967
83	cilium morphogenesis (GO:0060271)	2.58588063
84	negative regulation of organelle assembly (GO:1902116)	2.58172506
85	axoneme assembly (GO:0035082)	2.56430786
86	peptidyl-glutamic acid modification (GO:0018200)	2.42476167
87	mitochondrion degradation (GO:0000422)	2.42412168
88	UTP metabolic process (GO:0046051)	2.41145570
89	sperm motility (GO:0030317)	14.4712825
90	cell wall macromolecule metabolic process (GO:0044036)	13.4223607
91	cell wall macromolecule catabolic process (GO:0016998)	13.4223607
92	fusion of sperm to egg plasma membrane (GO:0007342)	13.3292828
93	acrosome reaction (GO:0007340)	12.4859432
94	sperm-egg recognition (GO:0035036)	11.6085560
95	acrosome assembly (GO:0001675)	11.6062690
96	multicellular organism reproduction (GO:0032504)	10.7027109
97	binding of sperm to zona pellucida (GO:0007339)	10.6645424
98	cell-cell recognition (GO:0009988)	10.3847206
99	plasma membrane fusion (GO:0045026)	10.1420301
100	epithelial cilium movement (GO:0003351)	10.1025804

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	9.08691351
2	EZH2_22144423_ChIP-Seq_EOC_Human	4.44753702
3	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.76768070
4	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.13527479
5	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.88690384
6	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.81833202
7	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.51613402
8	VDR_22108803_ChIP-Seq_LS180_Human	2.46409453
9	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	2.20346330
10	GATA1_26923725_Chip-Seq_HPCs_Mouse	2.17100616
11	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	2.07363665
12	ZNF274_21170338_ChIP-Seq_K562_Hela	2.06213925
13	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.99090761
14	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.88815121
15	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.82548168
16	FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.75021698
17	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.73946819
18	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.73537413
19	STAT1_17558387_ChIP-Seq_HELA_Human	1.70077536
20	ELK4_26923725_Chip-Seq_MESODERM_Mouse	1.69524600
21	SOX2_22085726_ChIP-Seq_NPCs_Mouse	1.66807654
22	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.66243409
23	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.57214473
24	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.55133098
25	GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse	1.54860406
26	GATA3_21867929_ChIP-Seq_CD8_Mouse	1.54129102
27	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.52859219
28	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.48139914
29	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.44484571
30	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.43158788
31	KDM2B_26808549_Chip-Seq_REH_Human	1.42519943
32	FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.41402185
33	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.39469073
34	CBP_20019798_ChIP-Seq_JUKART_Human	1.37119969
35	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.37119969
36	REST_21632747_ChIP-Seq_MESCs_Mouse	1.35415904
37	P53_21459846_ChIP-Seq_SAOS-2_Human	1.35163288
38	KAP1_22055183_ChIP-Seq_ESCs_Mouse	1.32856637
39	LUZP1_20508642_ChIP-Seq_ESCs_Mouse	1.32784730
40	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.31061931
41	GATA3_21867929_ChIP-Seq_TH1_Mouse	1.26562809
42	GF1_26923725_Chip-Seq_HPCs_Mouse	1.22749913
43	PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	1.22382728
44	RAD21_21589869_ChIP-Seq_MESCs_Mouse	1.22005437
45	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.21946504
46	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.21599856
47	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.21419007
48	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.21419007
49	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.20550025
50	SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.19027551
51	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.18547251
52	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.18495549
53	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.18477289
54	CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.18467246
55	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.18418822
56	CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.16656007
57	SPI1_26923725_Chip-Seq_HPCs_Mouse	1.15317169
58	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.13974564
59	SETDB1_19884257_ChIP-Seq_MESCs_Mouse	1.12791263
60	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.11230060
61	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.09783277
62	RXRA_24833708_ChIP-Seq_LIVER_Mouse	1.08333530
63	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.08255676
64	MYC_27129775_Chip-Seq_CORNEA_Mouse	1.08001700
65	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.07600132
66	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	1.06924797
67	ESET_19884257_ChIP-Seq_ESCs_Mouse	1.06045562
68	ERG_20517297_ChIP-Seq_VCAP_Human	1.05866195
69	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.05391060
70	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.05079506
71	NFIB_24661679_ChIP-Seq_LUNG_Mouse	1.04850124
72	GATA1_19941827_ChIP-Seq_MEL86_Mouse	1.04137874
73	JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse	1.03741085
74	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.03666412
75	RUNX1_26923725_Chip-Seq_HPCs_Mouse	1.03156744
76	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.02892500
77	RARA_24833708_ChIP-Seq_LIVER_Mouse	1.02758547
78	TAF15_26573619_Chip-Seq_HEK293_Human	1.02673071
79	PPARG_20176806_ChIP-Seq_3T3-L1_Mouse	1.02184994
80	CTCF_20526341_ChIP-Seq_ESCs_Human	0.98908175
81	PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse	0.98446239
82	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.98022640
83	SOX11_22085726_ChIP-Seq_ESNs_Mouse	0.97677796
84	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.97064504
85	SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	0.96539869
86	NFYB_21822215_ChIP-Seq_K562_Human	0.96304630
87	LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.95363392
88	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.94933578
89	FLI1_21867929_ChIP-Seq_CD8_Mouse	0.94923379
90	OCT4_18555785_Chip-Seq_ESCs_Mouse	0.94833525
91	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.93922187
92	P53_22387025_ChIP-Seq_ESCs_Mouse	0.93172726
93	CMYC_18555785_Chip-Seq_ESCs_Mouse	0.91825419
94	SOX9_26525672_Chip-Seq_HEART_Mouse	0.91439007
95	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	0.91097152
96	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.90386920
97	RNF2_27304074_Chip-Seq_NSC_Mouse	0.89896199
98	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.89405986
99	SRY_22984422_ChIP-ChIP_TESTIS_Rat	0.89115455
100	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.88086118

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003698_abnormal_male_reproductive	6.07010170
2	MP0001929_abnormal_gametogenesis	5.54179515
3	MP0008877_abnormal_DNA_methylation	3.79010355
4	MP0002161_abnormal_fertility/fecundity	3.32591695
5	MP0002210_abnormal_sex_determination	3.28047135
6	MP0005670_abnormal_white_adipose	2.86779570
7	MP0001145_abnormal_male_reproductive	2.82299890
8	MP0000653_abnormal_sex_gland	2.43125417
9	MP0002653_abnormal_ependyma_morphology	2.10876812
10	MP0005410_abnormal_fertilization	16.7191518
11	MP0002160_abnormal_reproductive_system	1.57507138
12	MP0004233_abnormal_muscle_weight	1.54771752
13	MP0003646_muscle_fatigue	1.50600309
14	MP0005623_abnormal_meninges_morphology	1.42870150
15	MP0002282_abnormal_trachea_morphology	1.24631386
16	MP0001765_abnormal_ion_homeostasis	1.11932139
17	MP0001984_abnormal_olfaction	1.08418209
18	MP0005647_abnormal_sex_gland	0.90587751
19	MP0008995_early_reproductive_senescence	0.84380250
20	MP0005389_reproductive_system_phenotype	0.77204312
21	MP0002234_abnormal_pharynx_morphology	0.77190132
22	MP0008058_abnormal_DNA_repair	0.72542157
23	MP0003115_abnormal_respiratory_system	0.71043268
24	MP0009046_muscle_twitch	0.68974299
25	MP0005636_abnormal_mineral_homeostasis	0.62056980
26	MP0009278_abnormal_bone_marrow	0.61884859
27	MP0003011_delayed_dark_adaptation	0.59289494
28	MP0001324_abnormal_eye_pigmentation	0.57400179
29	MP0003329_amyloid_beta_deposits	0.56758262
30	MP0003878_abnormal_ear_physiology	0.56264783
31	MP0005377_hearing/vestibular/ear_phenot	0.56264783
32	MP0005666_abnormal_adipose_tissue	0.54369457
33	MP0004036_abnormal_muscle_relaxation	0.50658813
34	MP0005253_abnormal_eye_physiology	0.50538320
35	MP0005397_hematopoietic_system_phenotyp	0.49392069
36	MP0001545_abnormal_hematopoietic_system	0.49392069
37	MP0003699_abnormal_female_reproductive	0.49070800
38	MP0000358_abnormal_cell_content/	0.48246574
39	MP0002269_muscular_atrophy	0.46557932
40	MP0001293_anophthalmia	0.44583862
41	MP0001764_abnormal_homeostasis	0.43370906
42	MP0001348_abnormal_lacrimal_gland	0.40922134
43	MP0005551_abnormal_eye_electrophysiolog	0.40552114
44	MP0010094_abnormal_chromosome_stability	0.40101844
45	MP0006036_abnormal_mitochondrial_physio	0.39667985
46	MP0002736_abnormal_nociception_after	0.39183933
47	MP0005391_vision/eye_phenotype	0.36132553
48	MP0004133_heterotaxia	0.35750994
49	MP0009115_abnormal_fat_cell	0.35366677
50	MP0000534_abnormal_ureter_morphology	0.34984483
51	MP0006035_abnormal_mitochondrial_morpho	0.34604055
52	MP0002928_abnormal_bile_duct	0.33975735
53	MP0008057_abnormal_DNA_replication	0.31972033
54	MP0003950_abnormal_plasma_membrane	0.31849955
55	MP0001727_abnormal_embryo_implantation	0.31066835
56	MP0004811_abnormal_neuron_physiology	0.29573619
57	MP0003633_abnormal_nervous_system	0.29570611
58	MP0002971_abnormal_brown_adipose	0.29183405
59	MP0003942_abnormal_urinary_system	0.28332233
60	MP0000604_amyloidosis	0.27768812
61	MP0000462_abnormal_digestive_system	0.26988297
62	MP0004742_abnormal_vestibular_system	0.26421481
63	MP0000569_abnormal_digit_pigmentation	0.25388968
64	MP0003861_abnormal_nervous_system	0.24970386
65	MP0004019_abnormal_vitamin_homeostasis	0.24366001
66	MP0003631_nervous_system_phenotype	0.24150187
67	MP0000920_abnormal_myelination	0.23921560
68	MP0002169_no_abnormal_phenotype	0.23913105
69	MP0002873_normal_phenotype	0.23760430
70	MP0002152_abnormal_brain_morphology	0.23637804
71	MP0004145_abnormal_muscle_electrophysio	0.23156305
72	MP0001119_abnormal_female_reproductive	0.21640818
73	MP0002139_abnormal_hepatobiliary_system	0.21279530
74	MP0001730_embryonic_growth_arrest	0.21249625
75	MP0002822_catalepsy	0.21076464
76	MP0001968_abnormal_touch/_nociception	0.20553868
77	MP0000751_myopathy	0.20058125
78	MP0003111_abnormal_nucleus_morphology	0.19838950
79	MP0003786_premature_aging	0.19698163
80	MP0003948_abnormal_gas_homeostasis	0.19614362
81	MP0002295_abnormal_pulmonary_circulatio	0.19177400
82	MP0002092_abnormal_eye_morphology	0.18494222
83	MP0004270_analgesia	0.18348577
84	MP0005195_abnormal_posterior_eye	0.16711727
85	MP0003879_abnormal_hair_cell	0.15962439
86	MP0001849_ear_inflammation	0.15923566
87	MP0006072_abnormal_retinal_apoptosis	0.15681267
88	MP0000313_abnormal_cell_death	0.15504545
89	MP0004043_abnormal_pH_regulation	0.15470605
90	MP0008569_lethality_at_weaning	0.15071516
91	MP0002229_neurodegeneration	0.14954956
92	MP0000001_mammalian_phenotype	0.14829606
93	MP0002084_abnormal_developmental_patter	0.14794073
94	MP0002108_abnormal_muscle_morphology	0.14744087
95	MP0005319_abnormal_enzyme/_coenzyme	0.14694206
96	MP0005375_adipose_tissue_phenotype	0.14266831
97	MP0003634_abnormal_glial_cell	0.14148649
98	MP0002102_abnormal_ear_morphology	0.14034507
99	MP0002909_abnormal_adrenal_gland	0.13781733
100	MP0002118_abnormal_lipid_homeostasis	0.12702553

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal respiratory motile cilium morphology (HP:0005938)	9.41815032
2	Abnormal respiratory epithelium morphology (HP:0012253)	9.41815032
3	Abnormal respiratory motile cilium physiology (HP:0012261)	9.36105845
4	Rhinitis (HP:0012384)	7.44706307
5	Chronic bronchitis (HP:0004469)	7.40936982
6	Abnormal ciliary motility (HP:0012262)	7.38703503
7	Infertility (HP:0000789)	7.08516211
8	Nasal polyposis (HP:0100582)	6.31855815
9	Abnormality of the nasal mucosa (HP:0000433)	5.18911647
10	Male infertility (HP:0003251)	5.05461638
11	Bronchitis (HP:0012387)	4.55294078
12	Bronchiectasis (HP:0002110)	4.35578043
13	Nephronophthisis (HP:0000090)	4.03705736
14	Abnormal spermatogenesis (HP:0008669)	3.58037193
15	Recurrent sinusitis (HP:0011108)	3.38438129
16	Recurrent otitis media (HP:0000403)	3.27546705
17	Abnormality of the renal medulla (HP:0100957)	3.01393306
18	Tubulointerstitial nephritis (HP:0001970)	2.95607599
19	Recurrent bronchitis (HP:0002837)	2.64865475
20	Impulsivity (HP:0100710)	2.55520598
21	Tubular atrophy (HP:0000092)	2.55042740
22	Molar tooth sign on MRI (HP:0002419)	2.45917294
23	Abnormality of midbrain morphology (HP:0002418)	2.45917294
24	Tubulointerstitial abnormality (HP:0001969)	2.44218813
25	Abnormal gallbladder physiology (HP:0012438)	2.41211320
26	Cholecystitis (HP:0001082)	2.41211320
27	Medial flaring of the eyebrow (HP:0010747)	2.38215453
28	Dyschromatopsia (HP:0007641)	2.29031463
29	Gonadotropin excess (HP:0000837)	2.23904824
30	Hemorrhage of the eye (HP:0011885)	2.22452662
31	Azoospermia (HP:0000027)	2.17361171
32	Decreased central vision (HP:0007663)	2.00527095
33	Dynein arm defect of respiratory motile cilia (HP:0012255)	13.5810922
34	Absent/shortened dynein arms (HP:0200106)	13.5810922
35	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	13.0783992
36	Choroideremia (HP:0001139)	1.99510561
37	Spastic tetraparesis (HP:0001285)	1.91421585
38	Tubulointerstitial fibrosis (HP:0005576)	1.90427982
39	Abnormal drinking behavior (HP:0030082)	1.84776917
40	Polydipsia (HP:0001959)	1.84776917
41	Congenital malformation of the right heart (HP:0011723)	1.80190387
42	Double outlet right ventricle (HP:0001719)	1.80190387
43	Postaxial foot polydactyly (HP:0001830)	1.75153809
44	Stage 5 chronic kidney disease (HP:0003774)	1.72144994
45	Abnormality of renal excretion (HP:0011036)	1.72004166
46	Heterotopia (HP:0002282)	1.69663856
47	Neurofibrillary tangles (HP:0002185)	1.69391486
48	Asymmetric septal hypertrophy (HP:0001670)	1.67766065
49	Hypoplasia of the capital femoral epiphysis (HP:0003090)	1.60499992
50	Abnormal biliary tract physiology (HP:0012439)	1.58137943
51	Bile duct proliferation (HP:0001408)	1.58137943
52	Abnormality of the dental root (HP:0006486)	1.56778753
53	Taurodontia (HP:0000679)	1.56778753
54	Abnormality of permanent molar morphology (HP:0011071)	1.56778753
55	Abnormality of the renal cortex (HP:0011035)	1.53383305
56	Congenital hepatic fibrosis (HP:0002612)	1.52148358
57	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.47514963
58	Abnormality of dentin (HP:0010299)	1.47196985
59	Bell-shaped thorax (HP:0001591)	1.46393807
60	Abnormality of the dental pulp (HP:0006479)	1.45428334
61	Abnormality of molar (HP:0011077)	1.44553708
62	Abnormality of molar morphology (HP:0011070)	1.44553708
63	Aplasia/Hypoplasia of the lens (HP:0008063)	1.44487268
64	Short ribs (HP:0000773)	1.44280218
65	Oculomotor apraxia (HP:0000657)	1.43082455
66	Abnormal urine output (HP:0012590)	1.42860287
67	Broad distal phalanx of finger (HP:0009836)	1.40847251
68	Bundle branch block (HP:0011710)	1.40751221
69	Postaxial hand polydactyly (HP:0001162)	1.36897284
70	Cerebral inclusion bodies (HP:0100314)	1.36560720
71	Fibular hypoplasia (HP:0003038)	1.34913324
72	Exercise-induced myalgia (HP:0003738)	1.32859656
73	Sensory axonal neuropathy (HP:0003390)	1.29442653
74	Cystic liver disease (HP:0006706)	1.28601828
75	Fatigable weakness (HP:0003473)	1.27589676
76	Abnormality of the neuromuscular junction (HP:0003398)	1.27589676
77	Renal dysplasia (HP:0000110)	1.26913303
78	Easy fatigability (HP:0003388)	1.26276904
79	Absent epiphyses (HP:0010577)	1.25562574
80	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	1.25562574
81	Deformed sella turcica (HP:0002681)	1.24631902
82	Gait imbalance (HP:0002141)	1.24036753
83	Congenital primary aphakia (HP:0007707)	1.23439704
84	Myoglobinuria (HP:0002913)	1.23371974
85	Abnormality of the lower motor neuron (HP:0002366)	1.22631348
86	Constricted visual fields (HP:0001133)	1.22070322
87	Chronic sinusitis (HP:0011109)	1.20932167
88	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	1.20066728
89	Polyuria (HP:0000103)	1.17386694
90	Hypercholesterolemia (HP:0003124)	1.17291169
91	Loss of speech (HP:0002371)	1.16913026
92	Hemiparesis (HP:0001269)	1.15416377
93	Vascular calcification (HP:0004934)	1.14466663
94	Rhabdomyolysis (HP:0003201)	1.12144138
95	Short femoral neck (HP:0100864)	1.12116840
96	Absent frontal sinuses (HP:0002688)	1.11236425
97	Facial cleft (HP:0002006)	1.10711042
98	Nephropathy (HP:0000112)	1.10098673
99	J-shaped sella turcica (HP:0002680)	1.08707525
100	Generalized muscle weakness (HP:0003324)	1.06975731

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PDK4	8.11913667
2	PDK3	8.11913667
3	TESK1	6.42035391
4	PDK2	5.24524314
5	PRKD3	4.88913236
6	ICK	4.85333946
7	PTK2B	2.22114565
8	STK39	2.09573539
9	WNK4	2.04987385
10	STK38	1.81132529
11	PNCK	1.74417487
12	DYRK1B	1.70800950
13	NEK2	1.50866584
14	MAPK15	1.27358871
15	PDK1	1.21314751
16	TYRO3	1.17540046
17	DYRK3	0.90943692
18	IRAK1	0.85210210
19	PDPK1	0.77269853
20	WNK1	0.74642587
21	PINK1	0.72544359
22	TESK2	0.65705024
23	RIPK4	0.64717738
24	PASK	0.60137402
25	MAP2K6	0.58948078
26	CHEK2	0.57947277
27	IRAK2	0.57595755
28	TTK	0.56990861
29	STK3	0.55998286
30	EEF2K	0.55166963
31	CCNB1	0.52021763
32	CAMK1G	0.43919618
33	PAK1	0.43506117
34	LMTK2	0.42757949
35	MUSK	0.39166619
36	NTRK2	0.37417415
37	PRKCG	0.35892691
38	CHEK1	0.35874810
39	STK38L	0.34848322
40	PAK2	0.34552415
41	MAP3K10	0.33944269
42	MARK2	0.26693963
43	ATM	0.25552631
44	MTOR	0.24006504
45	PAK4	0.23759672
46	TNIK	0.21813591
47	PRKAA1	0.21382737
48	PRKCZ	0.19273177
49	MAPKAPK5	0.18394915
50	CAMKK1	0.17772958
51	ATR	0.17244384
52	CDK15	0.16550651
53	RPS6KB1	0.16414082
54	CLK1	0.14313736
55	RPS6KA1	0.13920428
56	CDK18	0.13694153
57	NEK6	0.13217520
58	CDK11A	0.13109089
59	YES1	0.12679292
60	PRKCQ	0.12669389
61	CSK	0.12629399
62	EPHB1	0.12511468
63	PLK1	0.10856771
64	CDK6	0.10205848
65	CAMK2A	0.10183273
66	PRKG2	0.09083254
67	PLK4	0.08780459
68	CSNK2A1	0.08390992
69	CDK14	0.08168998
70	PIM1	0.08154133
71	GSK3B	0.07850721
72	WEE1	0.07806222
73	PKN1	0.06967927
74	CSNK1D	0.06927474
75	CSF1R	0.06503377
76	PRKACG	0.05710790
77	EGFR	0.05286067
78	DDR2	0.04872166
79	PRKCD	0.04819839
80	PRKG1	0.03941984
81	CSNK2A2	0.03175341
82	CDK2	0.02880400
83	MAPK8	0.02641695
84	BRSK2	0.02021062
85	CDK1	0.01985223
86	PRKCA	0.00783939
87	GSK3A	0.00742610
88	PRKCB	0.00539423
89	MAP3K5	-0.0288891
90	SRC	-0.0265195
91	AURKA	-0.0210681
92	RPS6KA3	-0.0173272
93	PRKACB	-0.0165400
94	PRKACA	-0.0164745
95	PDGFRB	-0.0140610
96	MARK3	-0.0119589
97	BRSK1	-0.0111314
98	BRAF	-0.0102307
99	CDC7	-0.0068563
100	UHMK1	-0.0057904

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Fatty acid biosynthesis_Homo sapiens_hsa00061	5.05722873
2	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	4.53121295
3	Vitamin B6 metabolism_Homo sapiens_hsa00750	3.58936753
4	Pyruvate metabolism_Homo sapiens_hsa00620	3.47281545
5	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	3.14612240
6	Linoleic acid metabolism_Homo sapiens_hsa00591	3.06471822
7	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	2.85193489
8	Propanoate metabolism_Homo sapiens_hsa00640	2.56225405
9	Glucagon signaling pathway_Homo sapiens_hsa04922	2.52349944
10	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	2.46007286
11	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	2.29972056
12	Basal transcription factors_Homo sapiens_hsa03022	2.01888427
13	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	2.00626847
14	Glycerolipid metabolism_Homo sapiens_hsa00561	1.89356116
15	Selenocompound metabolism_Homo sapiens_hsa00450	1.85888834
16	PPAR signaling pathway_Homo sapiens_hsa03320	1.84650024
17	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.79641189
18	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.65697847
19	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.65044010
20	Mineral absorption_Homo sapiens_hsa04978	1.63890264
21	Ether lipid metabolism_Homo sapiens_hsa00565	1.61900947
22	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.60598629
23	Oocyte meiosis_Homo sapiens_hsa04114	1.58918881
24	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.56230740
25	Fatty acid metabolism_Homo sapiens_hsa01212	1.53548325
26	Amphetamine addiction_Homo sapiens_hsa05031	1.48518925
27	Fat digestion and absorption_Homo sapiens_hsa04975	1.48510244
28	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.45597317
29	Pentose phosphate pathway_Homo sapiens_hsa00030	1.44949356
30	Cardiac muscle contraction_Homo sapiens_hsa04260	1.39865949
31	Fatty acid degradation_Homo sapiens_hsa00071	1.35525076
32	Carbon metabolism_Homo sapiens_hsa01200	1.29973092
33	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.27200981
34	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.25861125
35	Glutathione metabolism_Homo sapiens_hsa00480	1.19554238
36	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.13810487
37	Collecting duct acid secretion_Homo sapiens_hsa04966	1.06675194
38	Fanconi anemia pathway_Homo sapiens_hsa03460	1.04869071
39	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.04256246
40	Renin secretion_Homo sapiens_hsa04924	1.03973815
41	Antigen processing and presentation_Homo sapiens_hsa04612	1.00505575
42	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.96873849
43	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.96068872
44	Huntingtons disease_Homo sapiens_hsa05016	0.92994311
45	mRNA surveillance pathway_Homo sapiens_hsa03015	0.91979800
46	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.91325888
47	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.90272143
48	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.89314595
49	Purine metabolism_Homo sapiens_hsa00230	0.87887679
50	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.86856656
51	Insulin secretion_Homo sapiens_hsa04911	0.75479153
52	Chemical carcinogenesis_Homo sapiens_hsa05204	0.75314248
53	Bile secretion_Homo sapiens_hsa04976	0.71786717
54	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.71657909
55	Estrogen signaling pathway_Homo sapiens_hsa04915	0.71515824
56	Long-term potentiation_Homo sapiens_hsa04720	0.70326360
57	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.65453883
58	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.64143972
59	RNA transport_Homo sapiens_hsa03013	0.60868517
60	Legionellosis_Homo sapiens_hsa05134	0.56731434
61	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.54641642
62	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.53509096
63	Pancreatic secretion_Homo sapiens_hsa04972	0.53345629
64	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.52431002
65	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.49604935
66	VEGF signaling pathway_Homo sapiens_hsa04370	0.48945446
67	Salivary secretion_Homo sapiens_hsa04970	0.48539245
68	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.46106925
69	Protein digestion and absorption_Homo sapiens_hsa04974	0.45972326
70	Calcium signaling pathway_Homo sapiens_hsa04020	0.45180400
71	Endocytosis_Homo sapiens_hsa04144	0.43340805
72	AMPK signaling pathway_Homo sapiens_hsa04152	0.41500235
73	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.38872907
74	Renin-angiotensin system_Homo sapiens_hsa04614	0.38750878
75	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.38493139
76	ABC transporters_Homo sapiens_hsa02010	0.38402577
77	Sulfur metabolism_Homo sapiens_hsa00920	0.38216275
78	Gastric acid secretion_Homo sapiens_hsa04971	0.37464166
79	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.36539042
80	Metabolic pathways_Homo sapiens_hsa01100	0.36494814
81	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.35557816
82	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.33623545
83	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.31991352
84	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.30982287
85	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.30780431
86	cAMP signaling pathway_Homo sapiens_hsa04024	0.30052047
87	Alcoholism_Homo sapiens_hsa05034	0.26972333
88	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.26775581
89	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.26288178
90	Circadian entrainment_Homo sapiens_hsa04713	0.20896970
91	Taste transduction_Homo sapiens_hsa04742	0.20251619
92	Pyrimidine metabolism_Homo sapiens_hsa00240	0.17309176
93	Wnt signaling pathway_Homo sapiens_hsa04310	0.14521257
94	Basal cell carcinoma_Homo sapiens_hsa05217	0.12294580
95	Cocaine addiction_Homo sapiens_hsa05030	0.11537639
96	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.07580032
97	Toxoplasmosis_Homo sapiens_hsa05145	0.07349237
98	Glutamatergic synapse_Homo sapiens_hsa04724	0.06472747
99	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.05365622
100	Salmonella infection_Homo sapiens_hsa05132	0.05223104

SMIM23

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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