

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | neutrophil activation involved in immune response (GO:0002283) | 5.13707426 |
| 2 | positive regulation of chemokine biosynthetic process (GO:0045080) | 4.80549630 |
| 3 | modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00 | 4.63817950 |
| 4 | modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0 | 4.63817950 |
| 5 | positive regulation by organism of defense response of other organism involved in symbiotic interact | 4.63817950 |
| 6 | modulation by symbiont of host immune response (GO:0052553) | 4.63817950 |
| 7 | positive regulation by symbiont of host defense response (GO:0052509) | 4.63817950 |
| 8 | modulation by symbiont of host defense response (GO:0052031) | 4.63817950 |
| 9 | response to peptidoglycan (GO:0032494) | 4.55124855 |
| 10 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 4.48150411 |
| 11 | regulation of chemokine biosynthetic process (GO:0045073) | 3.88800531 |
| 12 | immunoglobulin mediated immune response (GO:0016064) | 3.82277183 |
| 13 | negative regulation of thymocyte apoptotic process (GO:0070244) | 3.76425066 |
| 14 | response to muramyl dipeptide (GO:0032495) | 3.73598647 |
| 15 | negative regulation of nitric oxide biosynthetic process (GO:0045019) | 3.71301436 |
| 16 | defense response to protozoan (GO:0042832) | 3.66294819 |
| 17 | positive regulation of gamma-delta T cell activation (GO:0046645) | 3.60451242 |
| 18 | respiratory burst (GO:0045730) | 3.58185914 |
| 19 | granulocyte activation (GO:0036230) | 3.52930497 |
| 20 | response to protozoan (GO:0001562) | 3.52057253 |
| 21 | low-density lipoprotein particle clearance (GO:0034383) | 3.51930871 |
| 22 | regulation of interferon-beta biosynthetic process (GO:0045357) | 3.49425756 |
| 23 | neutrophil activation (GO:0042119) | 3.47677601 |
| 24 | regulation of interleukin-12 biosynthetic process (GO:0045075) | 3.46638937 |
| 25 | macrophage activation involved in immune response (GO:0002281) | 3.40847542 |
| 26 | positive regulation of natural killer cell differentiation (GO:0032825) | 3.40662512 |
| 27 | lipopolysaccharide-mediated signaling pathway (GO:0031663) | 3.38361456 |
| 28 | pinocytosis (GO:0006907) | 3.38352831 |
| 29 | positive regulation of interferon-alpha production (GO:0032727) | 3.35749373 |
| 30 | negative regulation of interleukin-17 production (GO:0032700) | 3.35359540 |
| 31 | production of molecular mediator involved in inflammatory response (GO:0002532) | 3.33273750 |
| 32 | negative regulation of interleukin-12 production (GO:0032695) | 3.29474300 |
| 33 | mature B cell differentiation involved in immune response (GO:0002313) | 3.28930526 |
| 34 | leukocyte aggregation (GO:0070486) | 3.28284054 |
| 35 | myeloid dendritic cell differentiation (GO:0043011) | 3.28073311 |
| 36 | myeloid dendritic cell activation (GO:0001773) | 3.26758896 |
| 37 | regulation of interferon-alpha production (GO:0032647) | 3.21419919 |
| 38 | regulation of vitamin D biosynthetic process (GO:0060556) | 3.20965161 |
| 39 | regulation of platelet activation (GO:0010543) | 3.20874407 |
| 40 | myeloid cell activation involved in immune response (GO:0002275) | 3.16305479 |
| 41 | response to host immune response (GO:0052572) | 3.15878081 |
| 42 | response to immune response of other organism involved in symbiotic interaction (GO:0052564) | 3.15878081 |
| 43 | regulation of interleukin-17 production (GO:0032660) | 3.14788082 |
| 44 | regulation of mast cell degranulation (GO:0043304) | 3.12342253 |
| 45 | response to interferon-beta (GO:0035456) | 3.12325866 |
| 46 | Arp2/3 complex-mediated actin nucleation (GO:0034314) | 3.09872719 |
| 47 | negative regulation of erythrocyte differentiation (GO:0045647) | 3.09540476 |
| 48 | negative regulation of cytokine production involved in immune response (GO:0002719) | 3.09107140 |
| 49 | cellular response to thyroid hormone stimulus (GO:0097067) | 3.06753305 |
| 50 | regulation of platelet aggregation (GO:0090330) | 3.02288582 |
| 51 | positive regulation of mast cell degranulation (GO:0043306) | 3.01608470 |
| 52 | positive regulation of mast cell activation involved in immune response (GO:0033008) | 3.01608470 |
| 53 | cellular response to interferon-beta (GO:0035458) | 3.01409785 |
| 54 | negative regulation of lipid storage (GO:0010888) | 2.95296094 |
| 55 | response to host (GO:0075136) | 2.93773954 |
| 56 | response to host defenses (GO:0052200) | 2.93773954 |
| 57 | response to defenses of other organism involved in symbiotic interaction (GO:0052173) | 2.93773954 |
| 58 | regulation of dendritic cell antigen processing and presentation (GO:0002604) | 2.91759166 |
| 59 | positive regulation of mast cell activation (GO:0033005) | 2.91326141 |
| 60 | positive regulation of interleukin-17 production (GO:0032740) | 2.91194352 |
| 61 | negative regulation of macrophage derived foam cell differentiation (GO:0010745) | 2.90957048 |
| 62 | regulation of T-helper 2 cell differentiation (GO:0045628) | 2.90358385 |
| 63 | regulation of mast cell activation involved in immune response (GO:0033006) | 2.90140557 |
| 64 | negative regulation of myeloid cell apoptotic process (GO:0033033) | 2.89844153 |
| 65 | B cell mediated immunity (GO:0019724) | 2.89628400 |
| 66 | regulation of mast cell activation (GO:0033003) | 2.89436478 |
| 67 | positive regulation of type 2 immune response (GO:0002830) | 2.87738639 |
| 68 | cellular extravasation (GO:0045123) | 2.87270722 |
| 69 | regulation of mononuclear cell migration (GO:0071675) | 2.86258486 |
| 70 | positive regulation of antigen processing and presentation (GO:0002579) | 2.86113572 |
| 71 | adenosine receptor signaling pathway (GO:0001973) | 2.85409840 |
| 72 | regulation of chronic inflammatory response (GO:0002676) | 2.84679131 |
| 73 | purine nucleotide salvage (GO:0032261) | 2.84305053 |
| 74 | positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557) | 2.83773742 |
| 75 | regulation of cytokine secretion involved in immune response (GO:0002739) | 2.83609113 |
| 76 | interferon-gamma-mediated signaling pathway (GO:0060333) | 2.83219421 |
| 77 | regulation of podosome assembly (GO:0071801) | 2.82974920 |
| 78 | T-helper 1 type immune response (GO:0042088) | 2.81967920 |
| 79 | regulation of immunoglobulin secretion (GO:0051023) | 2.80253979 |
| 80 | regulation of B cell receptor signaling pathway (GO:0050855) | 2.79930807 |
| 81 | regulation of vitamin metabolic process (GO:0030656) | 2.77979197 |
| 82 | positive regulation of NF-kappaB import into nucleus (GO:0042346) | 2.77838217 |
| 83 | regulation of cholesterol storage (GO:0010885) | 2.77568042 |
| 84 | positive regulation of tumor necrosis factor production (GO:0032760) | 2.74756886 |
| 85 | regulation of syncytium formation by plasma membrane fusion (GO:0060142) | 2.73800527 |
| 86 | positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511) | 2.72980884 |
| 87 | NIK/NF-kappaB signaling (GO:0038061) | 2.72080333 |
| 88 | cellular response to exogenous dsRNA (GO:0071360) | 2.72018663 |
| 89 | cyclooxygenase pathway (GO:0019371) | 2.71416030 |
| 90 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 2.71138611 |
| 91 | antigen processing and presentation of endogenous antigen (GO:0019883) | 2.71069647 |
| 92 | myeloid leukocyte activation (GO:0002274) | 2.70544175 |
| 93 | positive regulation of B cell differentiation (GO:0045579) | 2.70097197 |
| 94 | superoxide anion generation (GO:0042554) | 2.69592628 |
| 95 | germinal center formation (GO:0002467) | 2.69400713 |
| 96 | mast cell activation (GO:0045576) | 2.68763793 |
| 97 | negative regulation of platelet activation (GO:0010544) | 2.68739428 |
| 98 | positive regulation of heat generation (GO:0031652) | 2.68525649 |
| 99 | positive regulation of interleukin-12 production (GO:0032735) | 2.67852007 |
| 100 | negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371) | 2.66592441 |
| 101 | negative regulation of T-helper cell differentiation (GO:0045623) | 2.66592441 |
| 102 | thrombin receptor signaling pathway (GO:0070493) | 2.65952763 |
| 103 | positive regulation of cytokine biosynthetic process (GO:0042108) | 2.64255071 |
| 104 | positive regulation of interleukin-10 production (GO:0032733) | 2.64218965 |
| 105 | response to interferon-alpha (GO:0035455) | 2.64067729 |
| 106 | positive regulation of interleukin-6 production (GO:0032755) | 2.63740722 |
| 107 | regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923) | 2.63245350 |
| 108 | modulation of growth of symbiont involved in interaction with host (GO:0044144) | 2.63217390 |
| 109 | regulation of growth of symbiont in host (GO:0044126) | 2.63217390 |
| 110 | negative regulation of growth of symbiont in host (GO:0044130) | 2.63217390 |
| 111 | negative regulation of growth of symbiont involved in interaction with host (GO:0044146) | 2.63217390 |
| 112 | positive regulation of chemokine production (GO:0032722) | 2.62165396 |
| 113 | positive regulation of membrane protein ectodomain proteolysis (GO:0051044) | 2.61616308 |
| 114 | positive regulation of macrophage differentiation (GO:0045651) | 2.61459533 |
| 115 | dendritic cell differentiation (GO:0097028) | 2.60613858 |
| 116 | microglial cell activation (GO:0001774) | 2.60313855 |
| 117 | negative regulation of mast cell activation (GO:0033004) | 2.60149083 |
| 118 | negative regulation of inflammatory response to antigenic stimulus (GO:0002862) | 2.59459464 |
| 119 | positive regulation of syncytium formation by plasma membrane fusion (GO:0060143) | 2.59339752 |
| 120 | regulation of interleukin-12 production (GO:0032655) | 2.59046007 |
| 121 | cellular response to zinc ion (GO:0071294) | 2.58479656 |
| 122 | angiogenesis involved in wound healing (GO:0060055) | 2.58190033 |
| 123 | phagocytosis, engulfment (GO:0006911) | 2.58120202 |
| 124 | type I interferon signaling pathway (GO:0060337) | 2.57691544 |
| 125 | cellular response to type I interferon (GO:0071357) | 2.57691544 |
| 126 | ribosomal small subunit assembly (GO:0000028) | 2.57524384 |
| 127 | regulation of T-helper 1 cell differentiation (GO:0045625) | 2.57149721 |
| 128 | regulation of membrane protein ectodomain proteolysis (GO:0051043) | 2.56530325 |
| 129 | negative regulation of bone mineralization (GO:0030502) | 2.56268999 |
| 130 | regulation of fever generation (GO:0031620) | 2.56155996 |
| 131 | response to type I interferon (GO:0034340) | 2.55950174 |
| 132 | regulation of antigen processing and presentation (GO:0002577) | 2.55494790 |
| 133 | lipoxygenase pathway (GO:0019372) | 2.55413485 |
| 134 | hydrogen peroxide biosynthetic process (GO:0050665) | 2.54903721 |
| 135 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 2.54614473 |
| 136 | negative regulation of homotypic cell-cell adhesion (GO:0034111) | 2.54157305 |
| 137 | regulation of macrophage derived foam cell differentiation (GO:0010743) | 2.53111401 |
| 138 | positive regulation of T-helper cell differentiation (GO:0045624) | 2.52881286 |
| 139 | glycosphingolipid catabolic process (GO:0046479) | 2.51404564 |
| 140 | regulation of leukocyte degranulation (GO:0043300) | 2.48307896 |
| 141 | cellular response to lipopolysaccharide (GO:0071222) | 2.47289226 |
| 142 | response to thyroid hormone (GO:0097066) | 2.46287278 |
| 143 | regulation of tumor necrosis factor biosynthetic process (GO:0042534) | 2.44437656 |
| 144 | negative regulation of cytokine secretion (GO:0050710) | 2.44301979 |
| 145 | regulation of T-helper cell differentiation (GO:0045622) | 2.43437271 |
| 146 | regulation of integrin activation (GO:0033623) | 2.42149293 |
| 147 | negative regulation of smooth muscle cell migration (GO:0014912) | 2.42029562 |
| 148 | regulation of type 2 immune response (GO:0002828) | 2.41797204 |
| 149 | negative regulation of T cell apoptotic process (GO:0070233) | 2.41774226 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 6.74411418 |
| 2 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 5.34743178 |
| 3 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 4.93780131 |
| 4 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 4.40580381 |
| 5 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 3.62801464 |
| 6 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 3.52198528 |
| 7 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 3.45362681 |
| 8 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 3.32495191 |
| 9 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 3.30063718 |
| 10 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 3.27379252 |
| 11 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 3.23942258 |
| 12 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 3.08286345 |
| 13 | SCL_19346495_ChIP-Seq_HPC-7_Human | 2.99501876 |
| 14 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 2.82734208 |
| 15 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 2.77184588 |
| 16 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 2.71627036 |
| 17 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 2.59612643 |
| 18 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 2.54572215 |
| 19 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 2.52425460 |
| 20 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 2.43486431 |
| 21 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 2.42513492 |
| 22 | SPI1_23547873_ChIP-Seq_NB4_Human | 2.38397065 |
| 23 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 2.36807033 |
| 24 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 2.13763896 |
| 25 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 2.11001514 |
| 26 | MYB_26560356_Chip-Seq_TH2_Human | 2.04909126 |
| 27 | VDR_24763502_ChIP-Seq_THP-1_Human | 2.04721549 |
| 28 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 2.02153958 |
| 29 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 2.01677156 |
| 30 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.97390254 |
| 31 | RUNX_20019798_ChIP-Seq_JUKART_Human | 1.85328761 |
| 32 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.85212607 |
| 33 | MAF_26560356_Chip-Seq_TH1_Human | 1.78687122 |
| 34 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 1.77013482 |
| 35 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.70879093 |
| 36 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.65663683 |
| 37 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.64979562 |
| 38 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 1.64191610 |
| 39 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.64048988 |
| 40 | E2F7_22180533_ChIP-Seq_HELA_Human | 1.63180420 |
| 41 | PU_27001747_Chip-Seq_BMDM_Mouse | 1.60282301 |
| 42 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.59640694 |
| 43 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 1.58015741 |
| 44 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 1.54378310 |
| 45 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.51785427 |
| 46 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 1.49542290 |
| 47 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.46932023 |
| 48 | MYB_26560356_Chip-Seq_TH1_Human | 1.46436199 |
| 49 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.44286950 |
| 50 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.43096533 |
| 51 | GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.42471576 |
| 52 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 1.41839898 |
| 53 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.37605036 |
| 54 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.33955936 |
| 55 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.32391813 |
| 56 | VDR_24787735_ChIP-Seq_THP-1_Human | 1.31834318 |
| 57 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.31526173 |
| 58 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 1.31178162 |
| 59 | SPI1_23127762_ChIP-Seq_K562_Human | 1.31117662 |
| 60 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 1.29718631 |
| 61 | RXR_22158963_ChIP-Seq_LIVER_Mouse | 1.28798709 |
| 62 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.27213583 |
| 63 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.27171420 |
| 64 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 1.25906815 |
| 65 | CLOCK_20551151_ChIP-Seq_293T_Human | 1.24709181 |
| 66 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 1.23661714 |
| 67 | MYC_22102868_ChIP-Seq_BL_Human | 1.23278222 |
| 68 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 1.23201594 |
| 69 | GATA1_22025678_ChIP-Seq_K562_Human | 1.22172465 |
| 70 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.21535751 |
| 71 | CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse | 1.19810980 |
| 72 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.19500142 |
| 73 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 1.19250790 |
| 74 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 1.18742837 |
| 75 | UTX_26944678_Chip-Seq_JUKART_Human | 1.18312000 |
| 76 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 1.17318551 |
| 77 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 1.17076724 |
| 78 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 1.15421531 |
| 79 | JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 1.15225847 |
| 80 | GATA3_27048872_Chip-Seq_THYMUS_Human | 1.14945901 |
| 81 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.14183015 |
| 82 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.13822263 |
| 83 | JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 1.13802403 |
| 84 | STAT1_20625510_ChIP-Seq_HELA_Human | 1.12900583 |
| 85 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.12804480 |
| 86 | ATF3_23680149_ChIP-Seq_GBM1-GSC_Human | 1.11745882 |
| 87 | TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 1.07814054 |
| 88 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 1.07624397 |
| 89 | SMAD3_18955504_ChIP-ChIP_HaCaT_Human | 1.05910426 |
| 90 | SMAD2_18955504_ChIP-ChIP_HaCaT_Human | 1.05910426 |
| 91 | CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.05899569 |
| 92 | GATA3_26560356_Chip-Seq_TH2_Human | 1.05552345 |
| 93 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.05064964 |
| 94 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.04917565 |
| 95 | NCOR1_26117541_ChIP-Seq_K562_Human | 1.04359198 |
| 96 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.03015664 |
| 97 | PPARA_22158963_ChIP-Seq_LIVER_Mouse | 1.02754142 |
| 98 | CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.02614142 |
| 99 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 1.01236154 |
| 100 | PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.00892933 |
| 101 | PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.00122732 |
| 102 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 0.99203352 |
| 103 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 0.95236635 |
| 104 | LXR_22158963_ChIP-Seq_LIVER_Mouse | 0.94772268 |
| 105 | RUNX2_24764292_ChIP-Seq_MC3T3_Mouse | 0.94342736 |
| 106 | SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.92559969 |
| 107 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.90710194 |
| 108 | SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse | 0.89904614 |
| 109 | HIF1A_21447827_ChIP-Seq_MCF-7_Human | 0.89705793 |
| 110 | PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.89587995 |
| 111 | NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human | 0.87831514 |
| 112 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 0.87488500 |
| 113 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 0.86496686 |
| 114 | CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse | 0.85001206 |
| 115 | SOX2_20726797_ChIP-Seq_SW620_Human | 0.84862996 |
| 116 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 0.84722394 |
| 117 | MAF_26560356_Chip-Seq_TH2_Human | 0.83910996 |
| 118 | GATA1_19941826_ChIP-Seq_K562_Human | 0.79657180 |
| 119 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 0.79053949 |
| 120 | GATA2_19941826_ChIP-Seq_K562_Human | 0.76169766 |
| 121 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 0.72128673 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0001835_abnormal_antigen_presentation | 3.91212203 |
| 2 | MP0003436_decreased_susceptibility_to | 3.66842652 |
| 3 | MP0009785_altered_susceptibility_to | 3.55139124 |
| 4 | MP0002148_abnormal_hypersensitivity_rea | 3.45676822 |
| 5 | MP0005000_abnormal_immune_tolerance | 3.03415765 |
| 6 | MP0002419_abnormal_innate_immunity | 3.00680958 |
| 7 | MP0001853_heart_inflammation | 2.86530814 |
| 8 | MP0005025_abnormal_response_to | 2.78880726 |
| 9 | MP0003303_peritoneal_inflammation | 2.77996091 |
| 10 | MP0005671_abnormal_response_to | 2.74073768 |
| 11 | MP0000685_abnormal_immune_system | 2.59659907 |
| 12 | MP0002452_abnormal_antigen_presenting | 2.54887692 |
| 13 | MP0003724_increased_susceptibility_to | 2.42485496 |
| 14 | MP0001790_abnormal_immune_system | 2.39166268 |
| 15 | MP0005387_immune_system_phenotype | 2.39166268 |
| 16 | MP0002723_abnormal_immune_serum | 2.29925222 |
| 17 | MP0001800_abnormal_humoral_immune | 2.27895479 |
| 18 | MP0002420_abnormal_adaptive_immunity | 2.20788922 |
| 19 | MP0001819_abnormal_immune_cell | 2.20461377 |
| 20 | MP0002405_respiratory_system_inflammati | 2.19316152 |
| 21 | MP0001533_abnormal_skeleton_physiology | 2.15023635 |
| 22 | MP0009278_abnormal_bone_marrow | 2.14027496 |
| 23 | MP0009840_abnormal_foam_cell | 2.05776266 |
| 24 | MP0005464_abnormal_platelet_physiology | 2.04171200 |
| 25 | MP0006082_CNS_inflammation | 1.95513507 |
| 26 | MP0009333_abnormal_splenocyte_physiolog | 1.94836112 |
| 27 | MP0005397_hematopoietic_system_phenotyp | 1.92145759 |
| 28 | MP0001545_abnormal_hematopoietic_system | 1.92145759 |
| 29 | MP0004510_myositis | 1.87392599 |
| 30 | MP0000343_altered_response_to | 1.85008584 |
| 31 | MP0003448_altered_tumor_morphology | 1.81688504 |
| 32 | MP0010155_abnormal_intestine_physiology | 1.81369277 |
| 33 | MP0000858_altered_metastatic_potential | 1.78682254 |
| 34 | MP0002933_joint_inflammation | 1.76582874 |
| 35 | MP0004947_skin_inflammation | 1.74769729 |
| 36 | MP0001845_abnormal_inflammatory_respons | 1.74614154 |
| 37 | MP0005058_abnormal_lysosome_morphology | 1.69021858 |
| 38 | MP0002398_abnormal_bone_marrow | 1.68131298 |
| 39 | MP0002396_abnormal_hematopoietic_system | 1.66934886 |
| 40 | MP0003279_aneurysm | 1.65000814 |
| 41 | MP0008438_abnormal_cutaneous_collagen | 1.62516418 |
| 42 | MP0009764_decreased_sensitivity_to | 1.61017736 |
| 43 | MP0000716_abnormal_immune_system | 1.60473093 |
| 44 | MP0004808_abnormal_hematopoietic_stem | 1.57086678 |
| 45 | MP0005451_abnormal_body_composition | 1.52788898 |
| 46 | MP0000689_abnormal_spleen_morphology | 1.47254913 |
| 47 | MP0003191_abnormal_cellular_cholesterol | 1.44610015 |
| 48 | MP0000465_gastrointestinal_hemorrhage | 1.42884544 |
| 49 | MP0010352_gastrointestinal_tract_polyps | 1.41398310 |
| 50 | MP0002722_abnormal_immune_system | 1.40582318 |
| 51 | MP0002429_abnormal_blood_cell | 1.39974362 |
| 52 | MP0002998_abnormal_bone_remodeling | 1.39018422 |
| 53 | MP0002006_tumorigenesis | 1.38843343 |
| 54 | MP0001873_stomach_inflammation | 1.37086824 |
| 55 | MP0003186_abnormal_redox_activity | 1.36746816 |
| 56 | MP0005390_skeleton_phenotype | 1.36446722 |
| 57 | MP0003075_altered_response_to | 1.32939842 |
| 58 | MP0008469_abnormal_protein_level | 1.31600180 |
| 59 | MP0002139_abnormal_hepatobiliary_system | 1.30582354 |
| 60 | MP0001851_eye_inflammation | 1.30152502 |
| 61 | MP0000490_abnormal_crypts_of | 1.27783807 |
| 62 | MP0003172_abnormal_lysosome_physiology | 1.21665491 |
| 63 | MP0003806_abnormal_nucleotide_metabolis | 1.21323615 |
| 64 | MP0002877_abnormal_melanocyte_morpholog | 1.19750387 |
| 65 | MP0005666_abnormal_adipose_tissue | 1.16442815 |
| 66 | MP0003763_abnormal_thymus_physiology | 1.16192447 |
| 67 | MP0005023_abnormal_wound_healing | 1.14151809 |
| 68 | MP0000604_amyloidosis | 1.14078975 |
| 69 | MP0005166_decreased_susceptibility_to | 1.12556486 |
| 70 | MP0003300_gastrointestinal_ulcer | 1.12544176 |
| 71 | MP0003828_pulmonary_edema | 1.10630443 |
| 72 | MP0003566_abnormal_cell_adhesion | 1.10116579 |
| 73 | MP0002332_abnormal_exercise_endurance | 1.08474507 |
| 74 | MP0001958_emphysema | 1.07493712 |
| 75 | MP0005174_abnormal_tail_pigmentation | 1.07357573 |
| 76 | MP0005164_abnormal_response_to | 1.06762225 |
| 77 | MP0006054_spinal_hemorrhage | 1.04065206 |
| 78 | MP0005310_abnormal_salivary_gland | 1.03632496 |
| 79 | MP0010307_abnormal_tumor_latency | 1.00941171 |
| 80 | MP0003656_abnormal_erythrocyte_physiolo | 0.99261901 |
| 81 | MP0003950_abnormal_plasma_membrane | 0.98535501 |
| 82 | MP0002166_altered_tumor_susceptibility | 0.98468655 |
| 83 | MP0009765_abnormal_xenobiotic_induced | 0.94445556 |
| 84 | MP0001849_ear_inflammation | 0.91903162 |
| 85 | MP0002254_reproductive_system_inflammat | 0.90761683 |
| 86 | MP0003795_abnormal_bone_structure | 0.89378978 |
| 87 | MP0000703_abnormal_thymus_morphology | 0.88083096 |
| 88 | MP0000249_abnormal_blood_vessel | 0.86967248 |
| 89 | MP0005670_abnormal_white_adipose | 0.84636715 |
| 90 | MP0003091_abnormal_cell_migration | 0.82302333 |
| 91 | MP0008004_abnormal_stomach_pH | 0.81597110 |
| 92 | MP0005535_abnormal_body_temperature | 0.81333682 |
| 93 | MP0003453_abnormal_keratinocyte_physiol | 0.80362612 |
| 94 | MP0001879_abnormal_lymphatic_vessel | 0.79688706 |
| 95 | MP0001881_abnormal_mammary_gland | 0.77971172 |
| 96 | MP0003866_abnormal_defecation | 0.77512241 |
| 97 | MP0002132_abnormal_respiratory_system | 0.75912865 |
| 98 | MP0005595_abnormal_vascular_smooth | 0.75003410 |
| 99 | MP0005503_abnormal_tendon_morphology | 0.73594288 |
| 100 | MP0005647_abnormal_sex_gland | 0.73471229 |
| 101 | MP0005167_abnormal_blood-brain_barrier | 0.73216556 |
| 102 | MP0000230_abnormal_systemic_arterial | 0.73184201 |
| 103 | MP0000767_abnormal_smooth_muscle | 0.72099760 |
| 104 | MP0008007_abnormal_cellular_replicative | 0.70541823 |
| 105 | MP0001663_abnormal_digestive_system | 0.70486714 |
| 106 | MP0002019_abnormal_tumor_incidence | 0.68705630 |
| 107 | MP0005375_adipose_tissue_phenotype | 0.68138272 |
| 108 | MP0009763_increased_sensitivity_to | 0.67207635 |
| 109 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.65786535 |
| 110 | MP0005257_abnormal_intraocular_pressure | 0.65279564 |
| 111 | MP0008260_abnormal_autophagy | 0.64641646 |
| 112 | MP0005319_abnormal_enzyme/_coenzyme | 0.64369798 |
| 113 | MP0003183_abnormal_peptide_metabolism | 0.64071244 |
| 114 | MP0002971_abnormal_brown_adipose | 0.63873630 |
| 115 | MP0005076_abnormal_cell_differentiation | 0.62954175 |
| 116 | MP0002295_abnormal_pulmonary_circulatio | 0.62309152 |
| 117 | MP0004883_abnormal_blood_vessel | 0.62263573 |
| 118 | MP0003705_abnormal_hypodermis_morpholog | 0.61569805 |
| 119 | MP0000627_abnormal_mammary_gland | 0.60110253 |
| 120 | MP0005165_increased_susceptibility_to | 0.59799302 |
| 121 | MP0002113_abnormal_skeleton_development | 0.57912813 |
| 122 | MP0001348_abnormal_lacrimal_gland | 0.57508594 |
| 123 | MP0009384_cardiac_valve_regurgitation | 0.57017569 |
| 124 | MP0001542_abnormal_bone_strength | 0.52069324 |
| 125 | MP0000372_irregular_coat_pigmentation | 0.51987447 |
| 126 | MP0008873_increased_physiological_sensi | 0.51982952 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Recurrent abscess formation (HP:0002722) | 6.17994641 |
| 2 | Elevated erythrocyte sedimentation rate (HP:0003565) | 5.85269449 |
| 3 | Eczematoid dermatitis (HP:0000976) | 5.43863593 |
| 4 | Recurrent bacterial skin infections (HP:0005406) | 5.38487352 |
| 5 | Myositis (HP:0100614) | 5.25221255 |
| 6 | Orchitis (HP:0100796) | 4.80402200 |
| 7 | Optic neuritis (HP:0100653) | 4.66981403 |
| 8 | Retrobulbar optic neuritis (HP:0100654) | 4.66981403 |
| 9 | Abnormality of macrophages (HP:0004311) | 4.43160425 |
| 10 | Mediastinal lymphadenopathy (HP:0100721) | 4.40423646 |
| 11 | Recurrent gram-negative bacterial infections (HP:0005420) | 4.04522502 |
| 12 | Stomatitis (HP:0010280) | 3.99675290 |
| 13 | Increased mean platelet volume (HP:0011877) | 3.96748839 |
| 14 | Menorrhagia (HP:0000132) | 3.89935887 |
| 15 | Abnormal platelet volume (HP:0011876) | 3.88204388 |
| 16 | Petechiae (HP:0000967) | 3.72311742 |
| 17 | Recurrent skin infections (HP:0001581) | 3.33306998 |
| 18 | Vacuolated lymphocytes (HP:0001922) | 3.31464677 |
| 19 | Interstitial pulmonary disease (HP:0006530) | 3.31174568 |
| 20 | Obstructive lung disease (HP:0006536) | 3.24307873 |
| 21 | Chronic obstructive pulmonary disease (HP:0006510) | 3.24307873 |
| 22 | Increased neuronal autofluorescent lipopigment (HP:0002074) | 3.20629917 |
| 23 | Peritonitis (HP:0002586) | 3.18125434 |
| 24 | Cellulitis (HP:0100658) | 3.16675929 |
| 25 | Abnormality of the vasculature of the conjunctiva (HP:0008054) | 3.08579794 |
| 26 | Myocardial infarction (HP:0001658) | 3.07187044 |
| 27 | Vasculitis (HP:0002633) | 3.06583299 |
| 28 | Recurrent fungal infections (HP:0002841) | 3.04169857 |
| 29 | Increased cerebral lipofuscin (HP:0011813) | 3.01727576 |
| 30 | Thrombocytosis (HP:0001894) | 3.00078270 |
| 31 | Urticaria (HP:0001025) | 2.99456207 |
| 32 | Keratoconjunctivitis sicca (HP:0001097) | 2.92888008 |
| 33 | Loss of speech (HP:0002371) | 2.92353063 |
| 34 | Pulmonary infiltrates (HP:0002113) | 2.90227662 |
| 35 | B lymphocytopenia (HP:0010976) | 2.85919044 |
| 36 | Gingivitis (HP:0000230) | 2.82413285 |
| 37 | Vertebral compression fractures (HP:0002953) | 2.81437484 |
| 38 | Abnormality of B cell number (HP:0010975) | 2.80625275 |
| 39 | Arterial thrombosis (HP:0004420) | 2.79864617 |
| 40 | Recurrent viral infections (HP:0004429) | 2.78872028 |
| 41 | Meningitis (HP:0001287) | 2.77710869 |
| 42 | Abnormality of polysaccharide metabolism (HP:0011012) | 2.69788554 |
| 43 | Abnormality of glycosaminoglycan metabolism (HP:0004371) | 2.69788554 |
| 44 | Abnormality of mucopolysaccharide metabolism (HP:0011020) | 2.69788554 |
| 45 | Urinary glycosaminoglycan excretion (HP:0003541) | 2.64399417 |
| 46 | Mucopolysacchariduria (HP:0008155) | 2.64399417 |
| 47 | Keratoconjunctivitis (HP:0001096) | 2.64168579 |
| 48 | Amyloidosis (HP:0011034) | 2.62320555 |
| 49 | Recurrent pneumonia (HP:0006532) | 2.59231208 |
| 50 | Autoimmune hemolytic anemia (HP:0001890) | 2.58948166 |
| 51 | Gastrointestinal infarctions (HP:0005244) | 2.57788504 |
| 52 | Basal ganglia calcification (HP:0002135) | 2.56595537 |
| 53 | Spondylolisthesis (HP:0003302) | 2.55043269 |
| 54 | Conjunctival telangiectasia (HP:0000524) | 2.54597283 |
| 55 | Leukocytosis (HP:0001974) | 2.53411909 |
| 56 | Panhypogammaglobulinemia (HP:0003139) | 2.47247034 |
| 57 | Nausea (HP:0002018) | 2.43313451 |
| 58 | Poor head control (HP:0002421) | 2.38653195 |
| 59 | Purpura (HP:0000979) | 2.38007805 |
| 60 | IgM deficiency (HP:0002850) | 2.33946484 |
| 61 | Abnormality of iron homeostasis (HP:0011031) | 2.33858412 |
| 62 | Epiphyseal dysplasia (HP:0002656) | 2.30301931 |
| 63 | Nuclear cataract (HP:0100018) | 2.28451516 |
| 64 | Autoimmune thrombocytopenia (HP:0001973) | 2.26896772 |
| 65 | Glomerulonephritis (HP:0000099) | 2.25962201 |
| 66 | Osteomyelitis (HP:0002754) | 2.25163458 |
| 67 | Pustule (HP:0200039) | 2.24849414 |
| 68 | Recurrent lower respiratory tract infections (HP:0002783) | 2.23690986 |
| 69 | Granulocytopenia (HP:0001913) | 2.22952987 |
| 70 | Hyperlipoproteinemia (HP:0010980) | 2.21906586 |
| 71 | Systemic lupus erythematosus (HP:0002725) | 2.18642402 |
| 72 | Disinhibition (HP:0000734) | 2.17403292 |
| 73 | Chronic otitis media (HP:0000389) | 2.16877398 |
| 74 | Tetraparesis (HP:0002273) | 2.06355300 |
| 75 | Abnormality of glycolipid metabolism (HP:0010969) | 2.06131269 |
| 76 | Abnormality of liposaccharide metabolism (HP:0010968) | 2.06131269 |
| 77 | Abnormality of glycosphingolipid metabolism (HP:0004343) | 2.06131269 |
| 78 | Abnormality of the common coagulation pathway (HP:0010990) | 2.05644852 |
| 79 | Bruising susceptibility (HP:0000978) | 2.05526615 |
| 80 | Aplastic anemia (HP:0001915) | 2.05056394 |
| 81 | Eosinophilia (HP:0001880) | 2.04277288 |
| 82 | Hemoptysis (HP:0002105) | 2.02707430 |
| 83 | T lymphocytopenia (HP:0005403) | 2.01263586 |
| 84 | Hepatosplenomegaly (HP:0001433) | 1.98957755 |
| 85 | Protrusio acetabuli (HP:0003179) | 1.98597030 |
| 86 | Spontaneous hematomas (HP:0007420) | 1.98579781 |
| 87 | Gastrointestinal stroma tumor (HP:0100723) | 1.98269511 |
| 88 | Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204) | 1.97976975 |
| 89 | Gingival bleeding (HP:0000225) | 1.97102127 |
| 90 | Abnormality of the peritoneum (HP:0002585) | 1.96758965 |
| 91 | Axonal loss (HP:0003447) | 1.94917085 |
| 92 | Paralysis (HP:0003470) | 1.94429922 |
| 93 | Prolonged bleeding time (HP:0003010) | 1.94093446 |
| 94 | Abnormality of transition element cation homeostasis (HP:0011030) | 1.93755800 |
| 95 | Hypertriglyceridemia (HP:0002155) | 1.93346524 |
| 96 | Polyneuropathy (HP:0001271) | 1.91690457 |
| 97 | Arthralgia (HP:0002829) | 1.91449487 |
| 98 | Chest pain (HP:0100749) | 1.91146023 |
| 99 | Glomerulopathy (HP:0100820) | 1.90487623 |
| 100 | Prostate neoplasm (HP:0100787) | 1.90162835 |
| 101 | Abnormality of the pericardium (HP:0001697) | 1.89989666 |
| 102 | Joint swelling (HP:0001386) | 1.89548636 |
| 103 | Abnormality of T cell number (HP:0011839) | 1.89489666 |
| 104 | Epistaxis (HP:0000421) | 1.88034448 |
| 105 | Syringomyelia (HP:0003396) | 1.87239112 |
| 106 | Spinal cord lesions (HP:0100561) | 1.87239112 |
| 107 | Skin ulcer (HP:0200042) | 1.86795957 |
| 108 | Onycholysis (HP:0001806) | 1.86442408 |
| 109 | Chronic mucocutaneous candidiasis (HP:0002728) | 1.86335938 |
| 110 | Recurrent cutaneous fungal infections (HP:0011370) | 1.86335938 |
| 111 | Mutism (HP:0002300) | 1.85184208 |
| 112 | Cervical subluxation (HP:0003308) | 1.84448651 |
| 113 | Lymphopenia (HP:0001888) | 1.84446216 |
| 114 | Complement deficiency (HP:0004431) | 1.83318312 |
| 115 | Abnormal platelet function (HP:0011869) | 1.83119827 |
| 116 | Impaired platelet aggregation (HP:0003540) | 1.83119827 |
| 117 | Mucosal telangiectasiae (HP:0100579) | 1.83105431 |
| 118 | Periodontitis (HP:0000704) | 1.82694024 |
| 119 | Sepsis (HP:0100806) | 1.82403468 |
| 120 | Polycythemia (HP:0001901) | 1.81026207 |
| 121 | Increased IgM level (HP:0003496) | 1.80568097 |
| 122 | Dysostosis multiplex (HP:0000943) | 1.80334494 |
| 123 | Beaking of vertebral bodies (HP:0004568) | 1.80319134 |
| 124 | Abnormality of cells of the lymphoid lineage (HP:0012140) | 1.79734403 |
| 125 | Anorexia (HP:0002039) | 1.79467228 |
| 126 | Progressive neurologic deterioration (HP:0002344) | 1.79017703 |
| 127 | Increased serum ferritin (HP:0003281) | 1.78531235 |
| 128 | Primitive reflexes (palmomental, snout, glabellar) (HP:0002476) | 1.78340138 |
| 129 | Albinism (HP:0001022) | 1.78091424 |
| 130 | Premature rupture of membranes (HP:0001788) | 1.77972510 |
| 131 | Dyschromatopsia (HP:0007641) | 1.77694091 |
| 132 | Episodic fever (HP:0001954) | 1.77451388 |
| 133 | Hypergammaglobulinemia (HP:0010702) | 1.76792087 |
| 134 | Abnormality of the pleura (HP:0002103) | 1.75922167 |
| 135 | Abnormality of the prostate (HP:0008775) | 1.75308379 |
| 136 | Encephalitis (HP:0002383) | 1.75096477 |
| 137 | Hematochezia (HP:0002573) | 1.72559721 |
| 138 | Gangrene (HP:0100758) | 1.70476369 |
| 139 | Abnormality of the lumbar spine (HP:0100712) | 1.70391275 |
| 140 | White forelock (HP:0002211) | 1.69897780 |
| 141 | Arterial tortuosity (HP:0005116) | 1.69370488 |
| 142 | Small epiphyses (HP:0010585) | 1.69013413 |
| 143 | Recurrent bronchitis (HP:0002837) | 1.66830374 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TBK1 | 3.38783121 |
| 2 | MAP3K14 | 3.33430971 |
| 3 | PIM2 | 3.29185290 |
| 4 | BLK | 3.07119591 |
| 5 | MAP4K1 | 2.91664940 |
| 6 | IKBKB | 2.67458479 |
| 7 | IRAK4 | 2.63973087 |
| 8 | TXK | 2.42115568 |
| 9 | MUSK | 2.42072360 |
| 10 | KIT | 2.34540177 |
| 11 | RIPK4 | 2.27429416 |
| 12 | PBK | 2.24049931 |
| 13 | IRAK3 | 2.10955471 |
| 14 | JAK3 | 2.04892560 |
| 15 | IKBKE | 2.02152970 |
| 16 | NME2 | 1.95844586 |
| 17 | BTK | 1.92115555 |
| 18 | TEC | 1.88464997 |
| 19 | PRPF4B | 1.81635895 |
| 20 | MST4 | 1.76862088 |
| 21 | MAP2K3 | 1.75947763 |
| 22 | ZAP70 | 1.65386012 |
| 23 | TGFBR2 | 1.59398728 |
| 24 | PIM1 | 1.54955540 |
| 25 | TYK2 | 1.52402732 |
| 26 | RPS6KA4 | 1.51267970 |
| 27 | EPHB1 | 1.48585311 |
| 28 | STK10 | 1.46898593 |
| 29 | ERN1 | 1.46643170 |
| 30 | TRPM7 | 1.40903792 |
| 31 | MAP3K3 | 1.37781628 |
| 32 | FGR | 1.35652277 |
| 33 | ADRBK2 | 1.32074474 |
| 34 | CHUK | 1.26517387 |
| 35 | LRRK2 | 1.25870998 |
| 36 | LYN | 1.23406167 |
| 37 | ARAF | 1.20038099 |
| 38 | MAP3K11 | 1.17789058 |
| 39 | CSF1R | 1.17160703 |
| 40 | SYK | 1.17141427 |
| 41 | BMX | 1.14962773 |
| 42 | MATK | 1.09964623 |
| 43 | LCK | 1.07414432 |
| 44 | TGFBR1 | 1.07162493 |
| 45 | CSK | 1.06995271 |
| 46 | HCK | 1.04756444 |
| 47 | DAPK3 | 1.02647828 |
| 48 | MAP3K5 | 1.01295929 |
| 49 | NEK9 | 1.01194627 |
| 50 | BMPR2 | 0.99033663 |
| 51 | CLK1 | 0.96138504 |
| 52 | ITK | 0.93886176 |
| 53 | TESK1 | 0.92981100 |
| 54 | STK24 | 0.92385863 |
| 55 | JAK1 | 0.91806806 |
| 56 | CDC42BPA | 0.91802084 |
| 57 | STK4 | 0.91500337 |
| 58 | MAP3K12 | 0.91069753 |
| 59 | GRK5 | 0.89525868 |
| 60 | TRIB3 | 0.88262424 |
| 61 | PRKG2 | 0.87704817 |
| 62 | TESK2 | 0.84775402 |
| 63 | GRK6 | 0.83536564 |
| 64 | PDGFRA | 0.83031243 |
| 65 | KDR | 0.82220580 |
| 66 | SCYL2 | 0.82206295 |
| 67 | TAOK1 | 0.81964077 |
| 68 | ABL2 | 0.73792431 |
| 69 | BCKDK | 0.72463753 |
| 70 | MOS | 0.67379392 |
| 71 | MAP3K13 | 0.67114265 |
| 72 | MAP3K10 | 0.66559750 |
| 73 | EIF2AK2 | 0.66413971 |
| 74 | FLT3 | 0.65082756 |
| 75 | FES | 0.64426404 |
| 76 | MAPKAPK3 | 0.64395055 |
| 77 | STK3 | 0.64206260 |
| 78 | BMPR1B | 0.62457300 |
| 79 | RPS6KA6 | 0.62356630 |
| 80 | MAPKAPK2 | 0.61537749 |
| 81 | ABL1 | 0.60274302 |
| 82 | JAK2 | 0.59971117 |
| 83 | PAK1 | 0.59434617 |
| 84 | RAF1 | 0.57621993 |
| 85 | PDK2 | 0.57542282 |
| 86 | TAOK2 | 0.57327292 |
| 87 | MAP3K1 | 0.56300891 |
| 88 | PAK4 | 0.55983464 |
| 89 | PRKCD | 0.55206143 |
| 90 | GRK7 | 0.54711346 |
| 91 | IRAK2 | 0.54452486 |
| 92 | PDK1 | 0.54111361 |
| 93 | ERBB3 | 0.53826141 |
| 94 | GSK3A | 0.53129417 |
| 95 | CDK6 | 0.51600242 |
| 96 | PDPK1 | 0.49825630 |
| 97 | SIK3 | 0.49239544 |
| 98 | PTK2B | 0.49081140 |
| 99 | YES1 | 0.48997642 |
| 100 | TAOK3 | 0.47718304 |
| 101 | ACVR1B | 0.47573604 |
| 102 | PAK2 | 0.47487855 |
| 103 | PKN2 | 0.46772089 |
| 104 | EEF2K | 0.46722039 |
| 105 | EIF2AK1 | 0.46381828 |
| 106 | RPS6KL1 | 0.46204543 |
| 107 | RPS6KC1 | 0.46204543 |
| 108 | DDR2 | 0.45991238 |
| 109 | TTN | 0.45935302 |
| 110 | EIF2AK3 | 0.44847079 |
| 111 | PIK3CG | 0.44690236 |
| 112 | RIPK1 | 0.44527484 |
| 113 | MARK3 | 0.41752396 |
| 114 | EGFR | 0.40588760 |
| 115 | MYLK | 0.40062274 |
| 116 | MAPK4 | 0.40012407 |
| 117 | TNK2 | 0.39913130 |
| 118 | PDGFRB | 0.38978254 |
| 119 | ILK | 0.38851145 |
| 120 | MAPK7 | 0.38791006 |
| 121 | NLK | 0.38558995 |
| 122 | MAP3K8 | 0.38524527 |
| 123 | PIK3CA | 0.37775119 |
| 124 | MST1R | 0.37650192 |
| 125 | ADRBK1 | 0.37058811 |
| 126 | IRAK1 | 0.36794632 |
| 127 | EPHA3 | 0.33766105 |
| 128 | HIPK2 | 0.33303783 |
| 129 | IGF1R | 0.32127167 |
| 130 | PKN1 | 0.31552376 |
| 131 | NUAK1 | 0.31368216 |
| 132 | INSR | 0.29632969 |
| 133 | MAP2K6 | 0.28864305 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Leishmaniasis_Homo sapiens_hsa05140 | 3.30895163 |
| 2 | Graft-versus-host disease_Homo sapiens_hsa05332 | 2.87029844 |
| 3 | Malaria_Homo sapiens_hsa05144 | 2.68432759 |
| 4 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 2.52102694 |
| 5 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 2.51903288 |
| 6 | Legionellosis_Homo sapiens_hsa05134 | 2.44593979 |
| 7 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 2.43447622 |
| 8 | Allograft rejection_Homo sapiens_hsa05330 | 2.43254896 |
| 9 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 2.21844538 |
| 10 | Osteoclast differentiation_Homo sapiens_hsa04380 | 2.14650075 |
| 11 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 2.09909783 |
| 12 | Pertussis_Homo sapiens_hsa05133 | 2.00437650 |
| 13 | Measles_Homo sapiens_hsa05162 | 1.96757097 |
| 14 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.96360253 |
| 15 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.90733196 |
| 16 | Asthma_Homo sapiens_hsa05310 | 1.88894842 |
| 17 | TNF signaling pathway_Homo sapiens_hsa04668 | 1.84235723 |
| 18 | Tuberculosis_Homo sapiens_hsa05152 | 1.81827807 |
| 19 | Salmonella infection_Homo sapiens_hsa05132 | 1.73349337 |
| 20 | Shigellosis_Homo sapiens_hsa05131 | 1.62868326 |
| 21 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 1.61865714 |
| 22 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.56102377 |
| 23 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 1.55234963 |
| 24 | Apoptosis_Homo sapiens_hsa04210 | 1.53691545 |
| 25 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 1.53465318 |
| 26 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.52725086 |
| 27 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.51991705 |
| 28 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 1.50933663 |
| 29 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.49659222 |
| 30 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 1.49197385 |
| 31 | Lysosome_Homo sapiens_hsa04142 | 1.47307919 |
| 32 | Influenza A_Homo sapiens_hsa05164 | 1.43377851 |
| 33 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.43063246 |
| 34 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 1.41197757 |
| 35 | Other glycan degradation_Homo sapiens_hsa00511 | 1.40691211 |
| 36 | Phagosome_Homo sapiens_hsa04145 | 1.40375811 |
| 37 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 1.36683781 |
| 38 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 1.36041367 |
| 39 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 1.34631776 |
| 40 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.30376818 |
| 41 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 1.20114133 |
| 42 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 1.15269743 |
| 43 | Hepatitis B_Homo sapiens_hsa05161 | 1.13750752 |
| 44 | African trypanosomiasis_Homo sapiens_hsa05143 | 1.12313078 |
| 45 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 1.09996936 |
| 46 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 1.09599586 |
| 47 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.08366444 |
| 48 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 1.02979107 |
| 49 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.00957549 |
| 50 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 1.00035218 |
| 51 | Ribosome_Homo sapiens_hsa03010 | 0.98926589 |
| 52 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.97692644 |
| 53 | Viral myocarditis_Homo sapiens_hsa05416 | 0.96259681 |
| 54 | PPAR signaling pathway_Homo sapiens_hsa03320 | 0.93570724 |
| 55 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 0.93293473 |
| 56 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.90685060 |
| 57 | Platelet activation_Homo sapiens_hsa04611 | 0.90364800 |
| 58 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.89264882 |
| 59 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.87879430 |
| 60 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.87584616 |
| 61 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.84478841 |
| 62 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.82889508 |
| 63 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.82403319 |
| 64 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.82048487 |
| 65 | Amoebiasis_Homo sapiens_hsa05146 | 0.81396995 |
| 66 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.80727150 |
| 67 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.80064782 |
| 68 | Hepatitis C_Homo sapiens_hsa05160 | 0.79339997 |
| 69 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.78677902 |
| 70 | Proteasome_Homo sapiens_hsa03050 | 0.77933144 |
| 71 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.76649975 |
| 72 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.71433526 |
| 73 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.67499831 |
| 74 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.65782582 |
| 75 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.65517159 |
| 76 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.65113880 |
| 77 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.63290272 |
| 78 | Galactose metabolism_Homo sapiens_hsa00052 | 0.62000050 |
| 79 | ECM-receptor interaction_Homo sapiens_hsa04512 | 0.60634215 |
| 80 | HTLV-I infection_Homo sapiens_hsa05166 | 0.58541313 |
| 81 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.58437211 |
| 82 | Protein export_Homo sapiens_hsa03060 | 0.58193590 |
| 83 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.56410528 |
| 84 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.56303888 |
| 85 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.56110955 |
| 86 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.55818441 |
| 87 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.54127132 |
| 88 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.52948209 |
| 89 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.52607038 |
| 90 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.46776610 |
| 91 | DNA replication_Homo sapiens_hsa03030 | 0.46292298 |
| 92 | Focal adhesion_Homo sapiens_hsa04510 | 0.45024001 |
| 93 | Prion diseases_Homo sapiens_hsa05020 | 0.44887057 |
| 94 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.43203973 |
| 95 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.43064995 |
| 96 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.42964265 |
| 97 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.41079293 |
| 98 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.39018562 |
| 99 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.38617921 |
| 100 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.37347116 |
| 101 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.36702057 |
| 102 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.36006360 |
| 103 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.35816628 |
| 104 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.34104268 |
| 105 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.33841666 |
| 106 | Bladder cancer_Homo sapiens_hsa05219 | 0.33149532 |
| 107 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 0.32967869 |
| 108 | Endocytosis_Homo sapiens_hsa04144 | 0.30405503 |
| 109 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.29378572 |
| 110 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.28907645 |
| 111 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.28562519 |
| 112 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.28464394 |
| 113 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.27890962 |
| 114 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.27662009 |
| 115 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.26074890 |

