ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	7.55544704
2	establishment of protein localization to mitochondrial membrane (GO:0090151)	6.75434719
3	ribosomal small subunit biogenesis (GO:0042274)	6.34272063
4	viral transcription (GO:0019083)	6.33852414
5	translational termination (GO:0006415)	6.06021706
6	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.92528453
7	protein targeting to ER (GO:0045047)	5.84051565
8	cotranslational protein targeting to membrane (GO:0006613)	5.83699949
9	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.60233551
10	protein localization to endoplasmic reticulum (GO:0070972)	5.57141265
11	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.52488733
12	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.38091422
13	ATP synthesis coupled proton transport (GO:0015986)	5.38091422
14	DNA deamination (GO:0045006)	5.25137918
15	translational elongation (GO:0006414)	5.15855496
16	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.88599861
17	viral life cycle (GO:0019058)	4.78546626
18	proteasome assembly (GO:0043248)	4.75327181
19	cellular protein complex disassembly (GO:0043624)	4.66695855
20	maturation of SSU-rRNA (GO:0030490)	4.56974248
21	respiratory electron transport chain (GO:0022904)	4.45009016
22	protein complex biogenesis (GO:0070271)	4.43744563
23	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.42455883
24	inner mitochondrial membrane organization (GO:0007007)	4.35469684
25	electron transport chain (GO:0022900)	4.33400354
26	respiratory chain complex IV assembly (GO:0008535)	4.31617613
27	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	4.31541241
28	ATP biosynthetic process (GO:0006754)	4.26090759
29	translational initiation (GO:0006413)	4.24793611
30	hydrogen ion transmembrane transport (GO:1902600)	4.18294891
31	mitochondrial respiratory chain complex assembly (GO:0033108)	4.11436547
32	translation (GO:0006412)	4.10273185
33	cytochrome complex assembly (GO:0017004)	4.09476343
34	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.04040124
35	NADH dehydrogenase complex assembly (GO:0010257)	4.04040124
36	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.04040124
37	water-soluble vitamin biosynthetic process (GO:0042364)	3.98174403
38	ribosomal large subunit biogenesis (GO:0042273)	3.93644329
39	protein localization to mitochondrion (GO:0070585)	3.89909801
40	protein complex disassembly (GO:0043241)	3.89756275
41	termination of RNA polymerase III transcription (GO:0006386)	3.76525053
42	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.76525053
43	signal peptide processing (GO:0006465)	3.76367796
44	protein targeting to membrane (GO:0006612)	3.72200465
45	protein neddylation (GO:0045116)	3.71013638
46	macromolecular complex disassembly (GO:0032984)	3.69755411
47	proton transport (GO:0015992)	3.68293798
48	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.65042318
49	intracellular protein transmembrane import (GO:0044743)	3.62934737
50	hydrogen transport (GO:0006818)	3.60311695
51	chaperone-mediated protein transport (GO:0072321)	3.55792353
52	spliceosomal snRNP assembly (GO:0000387)	3.52151112
53	mitochondrial transport (GO:0006839)	3.51797097
54	regulation of mitochondrial translation (GO:0070129)	3.51653408
55	response to interferon-beta (GO:0035456)	3.40161349
56	oxidative phosphorylation (GO:0006119)	3.39886925
57	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.36796253
58	platelet dense granule organization (GO:0060155)	3.35204935
59	cellular component biogenesis (GO:0044085)	3.34144373
60	ribonucleoprotein complex biogenesis (GO:0022613)	3.32040180
61	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	3.31828861
62	iron-sulfur cluster assembly (GO:0016226)	3.31693100
63	metallo-sulfur cluster assembly (GO:0031163)	3.31693100
64	protein-cofactor linkage (GO:0018065)	3.30023463
65	nucleoside triphosphate biosynthetic process (GO:0009142)	3.30008098
66	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.29685024
67	cullin deneddylation (GO:0010388)	3.27180570
68	GTP biosynthetic process (GO:0006183)	3.24978457
69	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.24537922
70	mRNA catabolic process (GO:0006402)	3.20779436
71	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.19635559
72	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.19635559
73	rRNA methylation (GO:0031167)	3.19319667
74	telomere maintenance via semi-conservative replication (GO:0032201)	3.19152368
75	polyketide metabolic process (GO:0030638)	3.17120348
76	doxorubicin metabolic process (GO:0044598)	3.17120348
77	daunorubicin metabolic process (GO:0044597)	3.17120348
78	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	3.14871270
79	antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	3.13467603
80	purine ribonucleoside monophosphate biosynthetic process (GO:0009168)	3.09982098
81	purine nucleoside monophosphate biosynthetic process (GO:0009127)	3.09982098
82	protein deneddylation (GO:0000338)	3.09480053
83	7-methylguanosine mRNA capping (GO:0006370)	3.06675432
84	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.04613234
85	chromatin remodeling at centromere (GO:0031055)	3.01032050
86	RNA capping (GO:0036260)	3.00774139
87	7-methylguanosine RNA capping (GO:0009452)	3.00774139
88	regulation of cellular amino acid metabolic process (GO:0006521)	2.99017365
89	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.98363570
90	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.97443330
91	RNA catabolic process (GO:0006401)	2.94824794
92	aerobic respiration (GO:0009060)	2.94097698
93	CTP biosynthetic process (GO:0006241)	2.92845218
94	CTP metabolic process (GO:0046036)	2.92845218
95	CENP-A containing nucleosome assembly (GO:0034080)	2.92711491
96	protein targeting to mitochondrion (GO:0006626)	2.91307752
97	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.90189388
98	maturation of 5.8S rRNA (GO:0000460)	2.89597496
99	rRNA processing (GO:0006364)	2.88999952
100	rRNA modification (GO:0000154)	2.86384900
101	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.86171641
102	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.83372844
103	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.83372844
104	guanosine-containing compound biosynthetic process (GO:1901070)	2.83317757
105	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.83056841
106	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.82403798
107	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.82403798
108	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.82403798
109	rRNA metabolic process (GO:0016072)	2.81620525
110	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.79363023
111	negative regulation of ligase activity (GO:0051352)	2.79363023
112	telomere maintenance via recombination (GO:0000722)	2.77478310
113	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.75549473
114	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.75016617
115	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.71801096
116	peptidyl-histidine modification (GO:0018202)	2.70890206
117	UTP biosynthetic process (GO:0006228)	2.70355477
118	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	2.70306746
119	establishment of protein localization to mitochondrion (GO:0072655)	2.68071680
120	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.67423826
121	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.66743345
122	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.66743345
123	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.64617937
124	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.63785412
125	pseudouridine synthesis (GO:0001522)	2.63127246
126	mannosylation (GO:0097502)	2.62528883

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	5.20090574
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.38807821
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.12676894
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.76766094
5	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.67107492
6	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.58860116
7	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	3.45391901
8	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.36187757
9	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.28176988
10	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.20451995
11	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	3.12023243
12	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.06415945
13	E2F7_22180533_ChIP-Seq_HELA_Human	3.00083149
14	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.95128078
15	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.72299531
16	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.70596198
17	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.67080155
18	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	2.66803174
19	VDR_23849224_ChIP-Seq_CD4+_Human	2.59652794
20	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.55289825
21	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.46448680
22	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.45381710
23	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	2.42775634
24	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	2.30216330
25	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	2.29513416
26	DCP1A_22483619_ChIP-Seq_HELA_Human	2.25488710
27	HOXB4_20404135_ChIP-ChIP_EML_Mouse	2.25131966
28	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.21949850
29	FOXP3_21729870_ChIP-Seq_TREG_Human	2.15316166
30	ELK1_19687146_ChIP-ChIP_HELA_Human	2.13458781
31	E2F1_18555785_ChIP-Seq_MESCs_Mouse	2.11492903
32	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	2.10706990
33	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.07559012
34	XRN2_22483619_ChIP-Seq_HELA_Human	2.06816625
35	ERG_20887958_ChIP-Seq_HPC-7_Mouse	2.02881558
36	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.96932046
37	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.95098640
38	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.94453729
39	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.90470538
40	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.89088572
41	TTF2_22483619_ChIP-Seq_HELA_Human	1.88138490
42	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.79578287
43	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.75060044
44	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.74325309
45	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.70352738
46	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.69790323
47	GABP_19822575_ChIP-Seq_HepG2_Human	1.69745714
48	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.65496805
49	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.62242293
50	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.55415217
51	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.54036232
52	SPI1_23547873_ChIP-Seq_NB4_Human	1.50250299
53	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.49852772
54	IRF1_19129219_ChIP-ChIP_H3396_Human	1.48986102
55	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.47739026
56	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.45560664
57	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.43537758
58	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.41569352
59	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.40669420
60	SCL_19346495_ChIP-Seq_HPC-7_Human	1.39189843
61	VDR_22108803_ChIP-Seq_LS180_Human	1.37213001
62	ZNF274_21170338_ChIP-Seq_K562_Hela	1.37187999
63	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	1.30830369
64	MYC_18940864_ChIP-ChIP_HL60_Human	1.30106416
65	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.28940917
66	EWS_26573619_Chip-Seq_HEK293_Human	1.24345250
67	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.20917454
68	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.20804109
69	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	1.20204948
70	KDM5A_27292631_Chip-Seq_BREAST_Human	1.17672130
71	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.12288516
72	CIITA_25753668_ChIP-Seq_RAJI_Human	1.12048813
73	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.08410259
74	FUS_26573619_Chip-Seq_HEK293_Human	1.06270324
75	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.05826055
76	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	1.05785477
77	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.05013155
78	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.04605958
79	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.03138955
80	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.03103355
81	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.02328409
82	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	1.02221920
83	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.01396411
84	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.99807816
85	TP53_22573176_ChIP-Seq_HFKS_Human	0.99395949
86	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	0.97210317
87	SRY_22984422_ChIP-ChIP_TESTIS_Rat	0.96707022
88	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.95966256
89	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.94983109
90	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	0.94613402
91	GATA1_22383799_ChIP-Seq_G1ME_Mouse	0.93954069
92	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.93535315
93	MYB_21317192_ChIP-Seq_ERMYB_Mouse	0.91660197
94	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	0.91168514
95	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.90508788
96	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.90480925
97	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.88474991
98	TFEB_21752829_ChIP-Seq_HELA_Human	0.88359991
99	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.88088387
100	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.87733248
101	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.86825001
102	MYCN_18555785_ChIP-Seq_MESCs_Mouse	0.86122604
103	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.84524831
104	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.84204349
105	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.83631787
106	IGF1R_20145208_ChIP-Seq_DFB_Human	0.81909282
107	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	0.81712054
108	GATA2_22383799_ChIP-Seq_G1ME_Mouse	0.81443185
109	NANOG_18555785_ChIP-Seq_MESCs_Mouse	0.80681412
110	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.80069542
111	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	0.78980270
112	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	0.78564683
113	AR_20517297_ChIP-Seq_VCAP_Human	0.77545026
114	E2F1_21310950_ChIP-Seq_MCF-7_Human	0.77026770
115	ERG_20517297_ChIP-Seq_VCAP_Human	0.76765624
116	SOX17_20123909_ChIP-Seq_XEN_Mouse	0.76729219
117	VDR_24763502_ChIP-Seq_THP-1_Human	0.76273404
118	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.75975874
119	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.75793668
120	HTT_18923047_ChIP-ChIP_STHdh_Human	0.75592695
121	PU.1_20513432_ChIP-Seq_Bcells_Mouse	0.75252014
122	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.74914191
123	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	0.74550884
124	ELF5_23300383_ChIP-Seq_T47D_Human	0.74137822
125	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.72761696
126	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.72751294
127	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.72751294
128	GATA1_22025678_ChIP-Seq_K562_Human	0.72185041
129	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.69756351

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	4.87281711
2	MP0003806_abnormal_nucleotide_metabolis	3.65068729
3	MP0002837_dystrophic_cardiac_calcinosis	3.63724961
4	MP0001835_abnormal_antigen_presentation	2.74856776
5	MP0009785_altered_susceptibility_to	2.72173060
6	MP0002638_abnormal_pupillary_reflex	2.68857351
7	MP0006292_abnormal_olfactory_placode	2.63386417
8	MP0003724_increased_susceptibility_to	2.59726112
9	MP0002132_abnormal_respiratory_system	2.54482679
10	MP0003186_abnormal_redox_activity	2.51740074
11	MP0005671_abnormal_response_to	2.51557376
12	MP0005174_abnormal_tail_pigmentation	2.38834157
13	MP0006072_abnormal_retinal_apoptosis	2.38693872
14	MP0002148_abnormal_hypersensitivity_rea	2.33549263
15	MP0003195_calcinosis	2.29165147
16	MP0003693_abnormal_embryo_hatching	2.25952828
17	MP0008995_early_reproductive_senescence	2.19869526
18	MP0004147_increased_porphyrin_level	2.06412955
19	MP0005075_abnormal_melanosome_morpholog	2.04469949
20	MP0000372_irregular_coat_pigmentation	2.01128447
21	MP0006036_abnormal_mitochondrial_physio	1.99680128
22	MP0003656_abnormal_erythrocyte_physiolo	1.94377175
23	MP0005025_abnormal_response_to	1.91438837
24	MP0003718_maternal_effect	1.88332290
25	MP0005000_abnormal_immune_tolerance	1.87559123
26	MP0001986_abnormal_taste_sensitivity	1.87105590
27	MP0003136_yellow_coat_color	1.86308149
28	MP0009333_abnormal_splenocyte_physiolog	1.85911815
29	MP0003646_muscle_fatigue	1.84912305
30	MP0003763_abnormal_thymus_physiology	1.83832604
31	MP0009697_abnormal_copulation	1.78208030
32	MP0001188_hyperpigmentation	1.76880537
33	MP0000015_abnormal_ear_pigmentation	1.73804514
34	MP0008058_abnormal_DNA_repair	1.73546646
35	MP0002396_abnormal_hematopoietic_system	1.72066485
36	MP0001853_heart_inflammation	1.69445573
37	MP0008877_abnormal_DNA_methylation	1.68500137
38	MP0003436_decreased_susceptibility_to	1.68152235
39	MP0002095_abnormal_skin_pigmentation	1.62265992
40	MP0001529_abnormal_vocalization	1.62253864
41	MP0005379_endocrine/exocrine_gland_phen	1.60107020
42	MP0003786_premature_aging	1.58721842
43	MP0002419_abnormal_innate_immunity	1.56336556
44	MP0000490_abnormal_crypts_of	1.55944997
45	MP0005409_darkened_coat_color	1.51414930
46	MP0005332_abnormal_amino_acid	1.49870784
47	MP0002420_abnormal_adaptive_immunity	1.49241494
48	MP0002163_abnormal_gland_morphology	1.49114262
49	MP0003111_abnormal_nucleus_morphology	1.48750754
50	MP0001764_abnormal_homeostasis	1.48127039
51	MP0002102_abnormal_ear_morphology	1.47922749
52	MP0002723_abnormal_immune_serum	1.47076495
53	MP0001819_abnormal_immune_cell	1.46133068
54	MP0008057_abnormal_DNA_replication	1.45747517
55	MP0002090_abnormal_vision	1.45615090
56	MP0001905_abnormal_dopamine_level	1.42747442
57	MP0004142_abnormal_muscle_tone	1.42622450
58	MP0005084_abnormal_gallbladder_morpholo	1.42416918
59	MP0002398_abnormal_bone_marrow	1.42003909
60	MP0002452_abnormal_antigen_presenting	1.41836614
61	MP0005253_abnormal_eye_physiology	1.41209955
62	MP0003123_paternal_imprinting	1.38788480
63	MP0001800_abnormal_humoral_immune	1.38598472
64	MP0002938_white_spotting	1.33069867
65	MP0010030_abnormal_orbit_morphology	1.32364516
66	MP0002160_abnormal_reproductive_system	1.30762838
67	MP0009046_muscle_twitch	1.30733825
68	MP0001984_abnormal_olfaction	1.30605428
69	MP0004381_abnormal_hair_follicle	1.30529003
70	MP0008007_abnormal_cellular_replicative	1.29461698
71	MP0005551_abnormal_eye_electrophysiolog	1.27089876
72	MP0000685_abnormal_immune_system	1.25652018
73	MP0000689_abnormal_spleen_morphology	1.25052315
74	MP0004957_abnormal_blastocyst_morpholog	1.24708727
75	MP0000716_abnormal_immune_system	1.23086250
76	MP0005645_abnormal_hypothalamus_physiol	1.23032820
77	MP0001485_abnormal_pinna_reflex	1.22876071
78	MP0002405_respiratory_system_inflammati	1.22516529
79	MP0001293_anophthalmia	1.21656488
80	MP0008789_abnormal_olfactory_epithelium	1.20777428
81	MP0005636_abnormal_mineral_homeostasis	1.19915160
82	MP0005464_abnormal_platelet_physiology	1.18549391
83	MP0005397_hematopoietic_system_phenotyp	1.18363408
84	MP0001545_abnormal_hematopoietic_system	1.18363408
85	MP0002429_abnormal_blood_cell	1.18300779
86	MP0003315_abnormal_perineum_morphology	1.18167459
87	MP0008469_abnormal_protein_level	1.18091529
88	MP0002722_abnormal_immune_system	1.16589070
89	MP0010094_abnormal_chromosome_stability	1.16364126
90	MP0006035_abnormal_mitochondrial_morpho	1.11433260
91	MP0005646_abnormal_pituitary_gland	1.11275146
92	MP0002006_tumorigenesis	1.11169928
93	MP0010386_abnormal_urinary_bladder	1.10603420
94	MP0000858_altered_metastatic_potential	1.10080800
95	MP0008875_abnormal_xenobiotic_pharmacok	1.10019239
96	MP0001845_abnormal_inflammatory_respons	1.09130538
97	MP0005389_reproductive_system_phenotype	1.05073311
98	MP0004019_abnormal_vitamin_homeostasis	1.03774958
99	MP0002277_abnormal_respiratory_mucosa	1.03551432
100	MP0001324_abnormal_eye_pigmentation	1.02721197
101	MP0002166_altered_tumor_susceptibility	1.02147221
102	MP0000516_abnormal_urinary_system	1.02098930
103	MP0005367_renal/urinary_system_phenotyp	1.02098930
104	MP0002693_abnormal_pancreas_physiology	1.01252703
105	MP0000681_abnormal_thyroid_gland	1.00694236
106	MP0003941_abnormal_skin_development	0.99957115
107	MP0010155_abnormal_intestine_physiology	0.99517723
108	MP0001756_abnormal_urination	0.97898762
109	MP0005387_immune_system_phenotype	0.97333411
110	MP0001790_abnormal_immune_system	0.97333411
111	MP0003866_abnormal_defecation	0.96914939
112	MP0009764_decreased_sensitivity_to	0.96343367
113	MP0002210_abnormal_sex_determination	0.96312290
114	MP0006276_abnormal_autonomic_nervous	0.96236277
115	MP0004215_abnormal_myocardial_fiber	0.96027895
116	MP0003121_genomic_imprinting	0.95000400
117	MP0003077_abnormal_cell_cycle	0.94184694
118	MP0003011_delayed_dark_adaptation	0.94022069
119	MP0003137_abnormal_impulse_conducting	0.93973527
120	MP0000049_abnormal_middle_ear	0.93523188
121	MP0000358_abnormal_cell_content/	0.91287893
122	MP0006054_spinal_hemorrhage	0.90003115
123	MP0003567_abnormal_fetal_cardiomyocyte	0.89320111
124	MP0002234_abnormal_pharynx_morphology	0.89236822
125	MP0000343_altered_response_to	0.87615143
126	MP0000703_abnormal_thymus_morphology	0.86186411
127	MP0005266_abnormal_metabolism	0.85929953
128	MP0002736_abnormal_nociception_after	0.85922063
129	MP0000465_gastrointestinal_hemorrhage	0.84374693
130	MP0002751_abnormal_autonomic_nervous	0.83790840
131	MP0005408_hypopigmentation	0.83682715
132	MP0005410_abnormal_fertilization	0.83377868
133	MP0004808_abnormal_hematopoietic_stem	0.82895428
134	MP0002139_abnormal_hepatobiliary_system	0.81541525
135	MP0001145_abnormal_male_reproductive	0.79709946
136	MP0002876_abnormal_thyroid_physiology	0.79458002
137	MP0000653_abnormal_sex_gland	0.77960412
138	MP0001929_abnormal_gametogenesis	0.77611564
139	MP0008932_abnormal_embryonic_tissue	0.77290153
140	MP0000631_abnormal_neuroendocrine_gland	0.76655419
141	MP0001944_abnormal_pancreas_morphology	0.76270363
142	MP0004145_abnormal_muscle_electrophysio	0.75695755
143	MP0002933_joint_inflammation	0.75284181
144	MP0001919_abnormal_reproductive_system	0.75018439
145	MP0004133_heterotaxia	0.74932120
146	MP0001663_abnormal_digestive_system	0.72933875
147	MP0008872_abnormal_physiological_respon	0.71843344
148	MP0005171_absent_coat_pigmentation	0.71659348
149	MP0005670_abnormal_white_adipose	0.69202151
150	MP0005195_abnormal_posterior_eye	0.69082684
151	MP0005391_vision/eye_phenotype	0.68483284
152	MP0000678_abnormal_parathyroid_gland	0.67380067
153	MP0000647_abnormal_sebaceous_gland	0.66358821
154	MP0005220_abnormal_exocrine_pancreas	0.65926331
155	MP0002254_reproductive_system_inflammat	0.64604613
156	MP0001186_pigmentation_phenotype	0.63744072
157	MP0002653_abnormal_ependyma_morphology	0.63510770
158	MP0001968_abnormal_touch/_nociception	0.62535870
159	MP0002822_catalepsy	0.61084547

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of cells of the erythroid lineage (HP:0012130)	5.50962468
2	Abnormal number of erythroid precursors (HP:0012131)	5.39092663
3	Mitochondrial inheritance (HP:0001427)	5.21172206
4	Acute necrotizing encephalopathy (HP:0006965)	5.16608194
5	Hepatocellular necrosis (HP:0001404)	4.97753043
6	Increased hepatocellular lipid droplets (HP:0006565)	4.82970567
7	Reticulocytopenia (HP:0001896)	4.79434108
8	Abnormal mitochondria in muscle tissue (HP:0008316)	4.76410840
9	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	4.59344090
10	Hepatic necrosis (HP:0002605)	4.51752932
11	Renal Fanconi syndrome (HP:0001994)	4.38868153
12	Increased CSF lactate (HP:0002490)	4.38806686
13	Lipid accumulation in hepatocytes (HP:0006561)	4.35835717
14	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	4.16107100
15	Progressive macrocephaly (HP:0004481)	4.14220397
16	Acute encephalopathy (HP:0006846)	4.13571102
17	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	4.02005782
18	Decreased activity of mitochondrial respiratory chain (HP:0008972)	4.02005782
19	Exertional dyspnea (HP:0002875)	3.99226150
20	3-Methylglutaconic aciduria (HP:0003535)	3.91396019
21	Increased intramyocellular lipid droplets (HP:0012240)	3.77533619
22	Type I transferrin isoform profile (HP:0003642)	3.71820860
23	Pallor (HP:0000980)	3.44146752
24	Hypothermia (HP:0002045)	3.43324047
25	Macrocytic anemia (HP:0001972)	3.36797791
26	Increased serum lactate (HP:0002151)	3.26891971
27	Aplastic anemia (HP:0001915)	3.26128222
28	Increased muscle lipid content (HP:0009058)	3.25974195
29	Reduced antithrombin III activity (HP:0001976)	3.19358936
30	Exercise intolerance (HP:0003546)	3.16183879
31	Respiratory difficulties (HP:0002880)	3.08887820
32	Abnormality of the heme biosynthetic pathway (HP:0010472)	3.08501744
33	Lactic acidosis (HP:0003128)	3.08285810
34	Abnormality of renal resorption (HP:0011038)	3.06280769
35	Abnormal glycosylation (HP:0012345)	2.84794655
36	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.84794655
37	Abnormal protein N-linked glycosylation (HP:0012347)	2.84794655
38	Abnormal protein glycosylation (HP:0012346)	2.84794655
39	Respiratory failure (HP:0002878)	2.83608052
40	Methylmalonic acidemia (HP:0002912)	2.74736108
41	Petechiae (HP:0000967)	2.71045585
42	Elevated erythrocyte sedimentation rate (HP:0003565)	2.71034365
43	Cerebral edema (HP:0002181)	2.70924385
44	Thrombocytosis (HP:0001894)	2.69382146
45	Optic disc pallor (HP:0000543)	2.67437826
46	Methylmalonic aciduria (HP:0012120)	2.57253220
47	Microvesicular hepatic steatosis (HP:0001414)	2.47467183
48	Generalized aminoaciduria (HP:0002909)	2.46766433
49	IgM deficiency (HP:0002850)	2.37120072
50	Glycosuria (HP:0003076)	2.35243890
51	Abnormality of urine glucose concentration (HP:0011016)	2.35243890
52	Increased serum pyruvate (HP:0003542)	2.32837529
53	Hyperphosphaturia (HP:0003109)	2.32752759
54	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.32113917
55	Hyperglycinemia (HP:0002154)	2.31199944
56	Absent thumb (HP:0009777)	2.28642058
57	Colon cancer (HP:0003003)	2.24470784
58	Recurrent abscess formation (HP:0002722)	2.23122819
59	Hypoglycemic coma (HP:0001325)	2.15381232
60	Renal tubular dysfunction (HP:0000124)	2.14039756
61	Abnormality of methionine metabolism (HP:0010901)	2.06715526
62	Leukodystrophy (HP:0002415)	2.06019348
63	Molar tooth sign on MRI (HP:0002419)	2.05749695
64	Abnormality of midbrain morphology (HP:0002418)	2.05749695
65	11 pairs of ribs (HP:0000878)	2.05602859
66	Vacuolated lymphocytes (HP:0001922)	2.05241820
67	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.05086033
68	Pancytopenia (HP:0001876)	2.01340107
69	Medial flaring of the eyebrow (HP:0010747)	2.01258087
70	Abnormality of glycolysis (HP:0004366)	1.99062120
71	Hyperinsulinemic hypoglycemia (HP:0000825)	1.96986744
72	Myositis (HP:0100614)	1.96802847
73	Abnormality of secondary sexual hair (HP:0009888)	1.95909445
74	Abnormality of the axillary hair (HP:0100134)	1.95909445
75	Abnormality of aromatic amino acid family metabolism (HP:0004338)	1.94459783
76	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.93920477
77	Abnormality of alanine metabolism (HP:0010916)	1.93920477
78	Hyperalaninemia (HP:0003348)	1.93920477
79	Aplasia/hypoplasia of the uterus (HP:0008684)	1.93492377
80	Type 2 muscle fiber atrophy (HP:0003554)	1.93076673
81	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.92415253
82	Dicarboxylic aciduria (HP:0003215)	1.92415253
83	Blindness (HP:0000618)	1.92158697
84	Recurrent bacterial skin infections (HP:0005406)	1.92023354
85	Birth length less than 3rd percentile (HP:0003561)	1.91927923
86	Oral leukoplakia (HP:0002745)	1.91882267
87	Patchy hypopigmentation of hair (HP:0011365)	1.91053799
88	Meckel diverticulum (HP:0002245)	1.89168088
89	Testicular atrophy (HP:0000029)	1.87876417
90	Prolonged bleeding time (HP:0003010)	1.86274901
91	Abnormality of serum amino acid levels (HP:0003112)	1.84560513
92	Degeneration of anterior horn cells (HP:0002398)	1.83652545
93	Abnormality of the anterior horn cell (HP:0006802)	1.83652545
94	Abnormal urine phosphate concentration (HP:0012599)	1.83591770
95	Abnormality of the ileum (HP:0001549)	1.80789442
96	Neutropenia (HP:0001875)	1.80606847
97	Muscle fiber atrophy (HP:0100295)	1.79916955
98	True hermaphroditism (HP:0010459)	1.77269746
99	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.75975782
100	Abnormality of placental membranes (HP:0011409)	1.75420467
101	Amniotic constriction ring (HP:0009775)	1.75420467
102	Sclerocornea (HP:0000647)	1.75231289
103	Renal cortical cysts (HP:0000803)	1.75038116
104	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.74796598
105	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.74531056
106	CNS demyelination (HP:0007305)	1.73444716
107	Congenital, generalized hypertrichosis (HP:0004540)	1.72790202
108	Chromsome breakage (HP:0040012)	1.72095826
109	Megaloblastic anemia (HP:0001889)	1.71432254
110	Vomiting (HP:0002013)	1.70905508
111	Abnormality of the columella (HP:0009929)	1.70598779
112	Irregular epiphyses (HP:0010582)	1.70524989
113	Thyroid-stimulating hormone excess (HP:0002925)	1.70236373
114	Abnormality of vitamin B metabolism (HP:0004340)	1.67593972
115	Abnormality of the preputium (HP:0100587)	1.64450068
116	Increased IgM level (HP:0003496)	1.62694593
117	Rough bone trabeculation (HP:0100670)	1.62466298
118	Septo-optic dysplasia (HP:0100842)	1.60518140
119	Congenital primary aphakia (HP:0007707)	1.60428918
120	Microretrognathia (HP:0000308)	1.60298083
121	Sparse eyelashes (HP:0000653)	1.60295489
122	Ketoacidosis (HP:0001993)	1.59851479
123	Emotional lability (HP:0000712)	1.57528030
124	Abnormality of reticulocytes (HP:0004312)	1.56909094
125	Beaking of vertebral bodies (HP:0004568)	1.56539377
126	Abnormal hemoglobin (HP:0011902)	1.55592077
127	Abnormality of B cell number (HP:0010975)	1.54714387
128	B lymphocytopenia (HP:0010976)	1.54714387
129	Esophageal neoplasm (HP:0100751)	1.54633971
130	Neoplasm of head and neck (HP:0012288)	1.54633971
131	Pancreatic cysts (HP:0001737)	1.54471129
132	Abnormal pupillary function (HP:0007686)	1.53370938
133	Dry hair (HP:0011359)	1.53073693
134	Lethargy (HP:0001254)	1.51331590
135	Severe visual impairment (HP:0001141)	1.50642804
136	Pancreatic fibrosis (HP:0100732)	1.50024625
137	Gliosis (HP:0002171)	1.48221218
138	Hypoplasia of the uterus (HP:0000013)	1.47944196
139	IgG deficiency (HP:0004315)	1.47104232
140	Flat capital femoral epiphysis (HP:0003370)	1.46624325
141	X-linked dominant inheritance (HP:0001423)	1.45965262

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	VRK2	4.92213668
2	NME2	3.96294795
3	STK16	3.84834065
4	TNIK	3.03869587
5	MUSK	2.81794027
6	MAP3K12	2.77416790
7	VRK1	2.64142888
8	CDC7	2.44405243
9	PIM2	2.40370794
10	EIF2AK1	2.22295351
11	IRAK4	2.18232164
12	EIF2AK3	2.16753112
13	TAOK3	2.06786515
14	FRK	2.06625149
15	SRPK1	2.04500421
16	TLK1	2.04260454
17	NME1	2.01263288
18	TEC	1.84368750
19	DYRK3	1.82743908
20	WNK3	1.81587980
21	NUAK1	1.80434557
22	CASK	1.77160349
23	ACVR1B	1.76255502
24	MAP4K2	1.74316638
25	CDK8	1.68226499
26	MYLK	1.63339013
27	WEE1	1.60912495
28	TRIM28	1.57131190
29	PLK3	1.56393440
30	IRAK3	1.52829239
31	MKNK2	1.52704608
32	PDK2	1.50764239
33	TXK	1.47884029
34	TAF1	1.43018232
35	MKNK1	1.39857512
36	KIT	1.35361652
37	BUB1	1.35020690
38	RPS6KA4	1.31935954
39	NEK1	1.31427803
40	ADRBK2	1.30778902
41	BTK	1.29025429
42	KDR	1.28128056
43	CDK19	1.24078776
44	GRK7	1.22491686
45	MAP3K14	1.22347763
46	INSRR	1.20781021
47	MST4	1.18466980
48	ZAK	1.17937424
49	CSNK1G1	1.17476214
50	CSNK1G3	1.17150154
51	EIF2AK2	1.16682811
52	TBK1	1.14399091
53	NLK	1.13284914
54	MAP3K11	1.07277913
55	IKBKE	1.06633626
56	MAP4K1	1.05483408
57	BMPR1B	1.02622412
58	CCNB1	0.98109440
59	MAP2K7	0.97887559
60	SYK	0.94465839
61	CSNK1G2	0.91538019
62	BMPR2	0.91094290
63	OXSR1	0.90528693
64	TTK	0.89835461
65	TESK2	0.89473741
66	IKBKB	0.89014236
67	YES1	0.88353581
68	LYN	0.86852249
69	PIK3CG	0.84488355
70	PHKG1	0.84347821
71	PHKG2	0.84347821
72	FLT3	0.82349140
73	BLK	0.80131809
74	WNK4	0.79902020
75	DAPK3	0.79847776
76	MAPKAPK5	0.78533692
77	RPS6KA5	0.78140305
78	CHEK2	0.77529493
79	CSNK1A1L	0.76697788
80	BCKDK	0.75800623
81	STK4	0.75648188
82	CDK7	0.73726569
83	TESK1	0.70273115
84	TGFBR1	0.69180985
85	PIM1	0.69022143
86	FES	0.68709008
87	PINK1	0.67416617
88	PRKCG	0.66420053
89	ZAP70	0.66128870
90	ARAF	0.65061352
91	ABL2	0.64380971
92	CSNK2A1	0.62394033
93	ILK	0.61851789
94	CAMKK2	0.61802389
95	AURKB	0.60328294
96	PBK	0.59105116
97	BRSK2	0.59049064
98	RPS6KB2	0.58018335
99	PLK4	0.57709108
100	IRAK2	0.56295618
101	DYRK2	0.55455377
102	PASK	0.54327224
103	TSSK6	0.54016057
104	LCK	0.53794813
105	MAPK4	0.53317273
106	IRAK1	0.52749502
107	CLK1	0.52734192
108	TYK2	0.52262676
109	STK39	0.51746159
110	RIPK4	0.51468776
111	MATK	0.50053394
112	GRK1	0.48589984
113	MAP3K4	0.48587346
114	CSNK2A2	0.48562667
115	CSNK1A1	0.46915363
116	PRKCE	0.45603642
117	PAK3	0.44852111
118	PRKG2	0.44191375
119	PLK2	0.43678869
120	GRK6	0.43521811
121	PRKCI	0.43336686
122	RPS6KA6	0.42752073
123	AURKA	0.42634157
124	ATR	0.41543037
125	PIK3CA	0.41483166
126	DAPK1	0.41253992
127	PLK1	0.41001086
128	CSNK1E	0.40333143
129	OBSCN	0.39412546
130	BRAF	0.39154219
131	MAP2K6	0.39040608
132	PRKCD	0.37867982
133	TNK2	0.37831022
134	LIMK1	0.36874283
135	STK3	0.36668873
136	ATM	0.36579383
137	RPS6KC1	0.36291244
138	RPS6KL1	0.36291244
139	CDK3	0.36057483
140	CAMK2D	0.35256152
141	FGFR2	0.34870428
142	PRKACA	0.34530746
143	STK24	0.34501265

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.53768103
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.13790123
3	Parkinsons disease_Homo sapiens_hsa05012	3.63002524
4	Protein export_Homo sapiens_hsa03060	3.60833664
5	Proteasome_Homo sapiens_hsa03050	3.35782619
6	RNA polymerase_Homo sapiens_hsa03020	3.27618616
7	DNA replication_Homo sapiens_hsa03030	2.87671402
8	Huntingtons disease_Homo sapiens_hsa05016	2.65876748
9	Alzheimers disease_Homo sapiens_hsa05010	2.55224882
10	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.47288272
11	Pyrimidine metabolism_Homo sapiens_hsa00240	2.39999416
12	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	2.28529895
13	Mismatch repair_Homo sapiens_hsa03430	2.07490310
14	Homologous recombination_Homo sapiens_hsa03440	2.02153615
15	Spliceosome_Homo sapiens_hsa03040	1.92602720
16	Nucleotide excision repair_Homo sapiens_hsa03420	1.78267905
17	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.73665781
18	Base excision repair_Homo sapiens_hsa03410	1.67175172
19	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.55750518
20	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.52214147
21	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.40950838
22	RNA degradation_Homo sapiens_hsa03018	1.36872896
23	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.32297550
24	Sulfur relay system_Homo sapiens_hsa04122	1.29314302
25	Purine metabolism_Homo sapiens_hsa00230	1.26458976
26	Basal transcription factors_Homo sapiens_hsa03022	1.25957740
27	Folate biosynthesis_Homo sapiens_hsa00790	1.18069978
28	Non-homologous end-joining_Homo sapiens_hsa03450	1.18043620
29	Sulfur metabolism_Homo sapiens_hsa00920	1.17240703
30	Fanconi anemia pathway_Homo sapiens_hsa03460	1.12018876
31	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.11315561
32	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.11126528
33	Propanoate metabolism_Homo sapiens_hsa00640	1.11086790
34	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.10048486
35	Primary immunodeficiency_Homo sapiens_hsa05340	1.07350916
36	Cardiac muscle contraction_Homo sapiens_hsa04260	1.05011713
37	Allograft rejection_Homo sapiens_hsa05330	1.03302784
38	Pyruvate metabolism_Homo sapiens_hsa00620	1.03189200
39	Butanoate metabolism_Homo sapiens_hsa00650	1.00961285
40	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.98579243
41	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.94942484
42	Graft-versus-host disease_Homo sapiens_hsa05332	0.94090193
43	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.91689343
44	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.91362411
45	Other glycan degradation_Homo sapiens_hsa00511	0.89432399
46	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.88501731
47	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.87988819
48	Glutathione metabolism_Homo sapiens_hsa00480	0.87537901
49	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.83629829
50	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.83310535
51	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.82822798
52	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.82254310
53	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.81725933
54	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.81224180
55	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.80567373
56	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.77958500
57	Legionellosis_Homo sapiens_hsa05134	0.77836744
58	Selenocompound metabolism_Homo sapiens_hsa00450	0.74791658
59	Asthma_Homo sapiens_hsa05310	0.74038765
60	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.73527370
61	RNA transport_Homo sapiens_hsa03013	0.73110687
62	Metabolic pathways_Homo sapiens_hsa01100	0.72865186
63	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.70154024
64	Herpes simplex infection_Homo sapiens_hsa05168	0.68584451
65	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.68392957
66	Rheumatoid arthritis_Homo sapiens_hsa05323	0.66502629
67	Tryptophan metabolism_Homo sapiens_hsa00380	0.64542570
68	Cell cycle_Homo sapiens_hsa04110	0.64279501
69	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.64242182
70	One carbon pool by folate_Homo sapiens_hsa00670	0.62232620
71	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.61973338
72	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.59883818
73	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.57886366
74	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.57139234
75	Pentose phosphate pathway_Homo sapiens_hsa00030	0.56136058
76	Chemical carcinogenesis_Homo sapiens_hsa05204	0.55884008
77	Antigen processing and presentation_Homo sapiens_hsa04612	0.55677578
78	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.55402670
79	Measles_Homo sapiens_hsa05162	0.55379905
80	Galactose metabolism_Homo sapiens_hsa00052	0.54187701
81	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.53693369
82	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.51659936
83	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.50812730
84	Type I diabetes mellitus_Homo sapiens_hsa04940	0.50698557
85	p53 signaling pathway_Homo sapiens_hsa04115	0.50160285
86	Regulation of autophagy_Homo sapiens_hsa04140	0.49348639
87	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.48611214
88	Phototransduction_Homo sapiens_hsa04744	0.46955418
89	Malaria_Homo sapiens_hsa05144	0.46929810
90	beta-Alanine metabolism_Homo sapiens_hsa00410	0.46632821
91	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.46609627
92	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.46532916
93	Leishmaniasis_Homo sapiens_hsa05140	0.46375105
94	Peroxisome_Homo sapiens_hsa04146	0.45298883
95	Carbon metabolism_Homo sapiens_hsa01200	0.45237504
96	Fatty acid degradation_Homo sapiens_hsa00071	0.44804613
97	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.43921979
98	Pertussis_Homo sapiens_hsa05133	0.41188613
99	Steroid biosynthesis_Homo sapiens_hsa00100	0.40306177
100	Arginine and proline metabolism_Homo sapiens_hsa00330	0.39909561
101	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.39622193
102	Fatty acid metabolism_Homo sapiens_hsa01212	0.37933189
103	Vibrio cholerae infection_Homo sapiens_hsa05110	0.34488626
104	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.34114083
105	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.33566668
106	Fatty acid elongation_Homo sapiens_hsa00062	0.32915862
107	Collecting duct acid secretion_Homo sapiens_hsa04966	0.32218014
108	Mineral absorption_Homo sapiens_hsa04978	0.31066981
109	Nitrogen metabolism_Homo sapiens_hsa00910	0.29113188
110	Phagosome_Homo sapiens_hsa04145	0.28969784
111	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.28854378
112	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.28559511
113	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.28551240
114	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.27510615
115	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.26671952
116	Tyrosine metabolism_Homo sapiens_hsa00350	0.25343185
117	Sphingolipid metabolism_Homo sapiens_hsa00600	0.24095164
118	Linoleic acid metabolism_Homo sapiens_hsa00591	0.23999063
119	Caffeine metabolism_Homo sapiens_hsa00232	0.23527626
120	Alcoholism_Homo sapiens_hsa05034	0.22903809
121	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.22107849
122	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.21197590
123	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.20868740
124	Retinol metabolism_Homo sapiens_hsa00830	0.20403117
125	African trypanosomiasis_Homo sapiens_hsa05143	0.19929778
126	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.19772284
127	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.19754121
128	Apoptosis_Homo sapiens_hsa04210	0.19513810
129	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.18856149
130	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.17383420
131	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.14387025
132	mRNA surveillance pathway_Homo sapiens_hsa03015	0.13149887
133	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.13111366

SMIM4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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