SMIM5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)8.34895219
2neutrophil activation involved in immune response (GO:0002283)6.44382814
3thrombin receptor signaling pathway (GO:0070493)6.40066612
4protein neddylation (GO:0045116)6.28812303
5viral transcription (GO:0019083)6.10838814
6translational termination (GO:0006415)5.79803287
7definitive hemopoiesis (GO:0060216)5.77825636
8regulation of platelet aggregation (GO:0090330)5.31127650
9SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.23381365
10translational elongation (GO:0006414)5.17523382
11cotranslational protein targeting to membrane (GO:0006613)5.14322993
12ribosomal small subunit biogenesis (GO:0042274)5.14126380
13protein targeting to ER (GO:0045047)5.09678029
14DNA deamination (GO:0045006)4.97768595
15establishment of protein localization to endoplasmic reticulum (GO:0072599)4.87662886
16protein localization to endoplasmic reticulum (GO:0070972)4.85947720
17maturation of SSU-rRNA (GO:0030490)4.78784804
18regulation of platelet activation (GO:0010543)4.73332839
19antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.57859448
20viral life cycle (GO:0019058)4.49701731
21triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.48764723
22adenosine receptor signaling pathway (GO:0001973)4.42131305
23leukocyte migration involved in inflammatory response (GO:0002523)4.41038348
24regulation of integrin-mediated signaling pathway (GO:2001044)4.39726116
25lipoxygenase pathway (GO:0019372)4.36046052
26cellular protein complex disassembly (GO:0043624)4.35467344
27nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.30975692
28doxorubicin metabolic process (GO:0044598)4.29000452
29daunorubicin metabolic process (GO:0044597)4.29000452
30polyketide metabolic process (GO:0030638)4.29000452
31phospholipid scrambling (GO:0017121)4.28256849
32negative regulation of thymocyte apoptotic process (GO:0070244)4.26447486
33positive regulation of B cell differentiation (GO:0045579)4.18415622
34neutrophil activation (GO:0042119)4.14931623
35blood coagulation, intrinsic pathway (GO:0007597)4.13562001
36negative regulation of heart rate (GO:0010459)4.10354149
37oxygen transport (GO:0015671)4.01542023
38negative regulation of macrophage derived foam cell differentiation (GO:0010745)4.00483510
39platelet aggregation (GO:0070527)3.92674095
40purinergic nucleotide receptor signaling pathway (GO:0035590)3.91512155
41antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.90243469
42antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.90243469
43negative regulation of platelet activation (GO:0010544)3.90224541
44positive regulation of endothelial cell differentiation (GO:0045603)3.89187278
45translational initiation (GO:0006413)3.89139309
46G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.82481146
47protein complex disassembly (GO:0043241)3.81087535
48negative regulation of norepinephrine secretion (GO:0010700)3.78626492
49low-density lipoprotein particle remodeling (GO:0034374)3.73987562
50negative regulation of homotypic cell-cell adhesion (GO:0034111)3.73633313
51heme biosynthetic process (GO:0006783)3.71463742
52positive regulation of systemic arterial blood pressure (GO:0003084)3.64776957
53negative regulation of erythrocyte differentiation (GO:0045647)3.64295426
54granulocyte activation (GO:0036230)3.62269237
55positive regulation of mast cell activation (GO:0033005)3.61172926
56axonemal dynein complex assembly (GO:0070286)3.59475372
57erythrocyte maturation (GO:0043249)3.56106389
58macromolecular complex disassembly (GO:0032984)3.55621089
59platelet dense granule organization (GO:0060155)3.55180252
60regulation of integrin activation (GO:0033623)3.53974415
61response to interferon-beta (GO:0035456)3.52733318
62fusion of sperm to egg plasma membrane (GO:0007342)3.51713885
63negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.50365749
64protoporphyrinogen IX biosynthetic process (GO:0006782)3.47855579
65gas transport (GO:0015669)3.47705818
66platelet formation (GO:0030220)3.44013113
67protein targeting to membrane (GO:0006612)3.43787063
68lymphoid progenitor cell differentiation (GO:0002320)3.43574311
69positive regulation of granulocyte differentiation (GO:0030854)3.38699138
70positive regulation of cAMP-mediated signaling (GO:0043950)3.37651435
71GTP biosynthetic process (GO:0006183)3.37338234
72autophagic vacuole fusion (GO:0000046)3.35908036
73cilium or flagellum-dependent cell motility (GO:0001539)3.35793392
74histamine transport (GO:0051608)3.35292465
75negative regulation of protein localization to cell surface (GO:2000009)3.33730199
76negative regulation of appetite (GO:0032099)3.31779829
77negative regulation of response to food (GO:0032096)3.31779829
78protoporphyrinogen IX metabolic process (GO:0046501)3.29710815
79telomere maintenance via semi-conservative replication (GO:0032201)3.27465049
80epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.27382657
81antigen processing and presentation via MHC class Ib (GO:0002475)3.26284638
82purinergic receptor signaling pathway (GO:0035587)3.25271076
83superoxide anion generation (GO:0042554)3.24633051
84regulation of erythrocyte differentiation (GO:0045646)3.22873388
85antigen processing and presentation of endogenous antigen (GO:0019883)3.22354471
86aminoglycoside antibiotic metabolic process (GO:0030647)3.20950273
87nuclear-transcribed mRNA catabolic process (GO:0000956)3.15578323
88regulation of lipoprotein metabolic process (GO:0050746)3.15058205
89polyamine biosynthetic process (GO:0006596)3.14834832
90regulation of MHC class II biosynthetic process (GO:0045346)3.14401283
91regulation of macrophage derived foam cell differentiation (GO:0010743)3.13818936
92heme metabolic process (GO:0042168)3.11251398
93megakaryocyte development (GO:0035855)3.10741295
94positive regulation of receptor recycling (GO:0001921)3.09921491
95translation (GO:0006412)3.09761071
96CTP biosynthetic process (GO:0006241)3.05317568
97CTP metabolic process (GO:0046036)3.05317568
98deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.05197318
99mRNA catabolic process (GO:0006402)3.04947025
100DNA replication initiation (GO:0006270)3.03688448
101ribosomal large subunit biogenesis (GO:0042273)3.02204813
102positive regulation of macrophage differentiation (GO:0045651)3.00618027
103cilium movement (GO:0003341)2.98934289
104termination of G-protein coupled receptor signaling pathway (GO:0038032)2.98529852
105UTP biosynthetic process (GO:0006228)2.96066179
106secretory granule organization (GO:0033363)2.96007174
107termination of signal transduction (GO:0023021)2.93886318
108extracellular fibril organization (GO:0043206)2.89913807
109regulation of homotypic cell-cell adhesion (GO:0034110)2.89317885
110negative regulation of phagocytosis (GO:0050765)2.89211598
111regulation of B cell differentiation (GO:0045577)2.88513353
112innate immune response in mucosa (GO:0002227)2.87841122
113UTP metabolic process (GO:0046051)2.87836191
114defense response to protozoan (GO:0042832)2.87345823
115G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.86506157
116RNA catabolic process (GO:0006401)2.85422430
117myeloid cell development (GO:0061515)2.85255964
118positive regulation of gamma-delta T cell activation (GO:0046645)2.85043357
119DNA strand elongation involved in DNA replication (GO:0006271)2.83872292
120proteasome assembly (GO:0043248)2.83780829
121response to interferon-alpha (GO:0035455)2.83691879
122regulation of natural killer cell differentiation (GO:0032823)2.83547828
123homotypic cell-cell adhesion (GO:0034109)2.83531816
124regulation of endothelial cell differentiation (GO:0045601)2.83140703
125regulation of memory T cell differentiation (GO:0043380)2.82162453
126high-density lipoprotein particle remodeling (GO:0034375)2.81535407
127endosome to pigment granule transport (GO:0043485)2.80676698
128endosome to melanosome transport (GO:0035646)2.80676698
129angiogenesis involved in wound healing (GO:0060055)2.79679272
130antibacterial humoral response (GO:0019731)2.79175461
131platelet degranulation (GO:0002576)2.78961045
132regulation of cholesterol efflux (GO:0010874)2.78218318
133platelet activation (GO:0030168)2.77852564
134regulation of female receptivity (GO:0045924)2.77829012
135phosphatidylinositol acyl-chain remodeling (GO:0036149)2.77485725
136pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.77186106
137one-carbon compound transport (GO:0019755)2.76786986
138response to protozoan (GO:0001562)2.76189181
139dopamine transport (GO:0015872)2.75630424
140fucose catabolic process (GO:0019317)2.75025102
141L-fucose metabolic process (GO:0042354)2.75025102
142L-fucose catabolic process (GO:0042355)2.75025102
143pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.74582518
144negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.73514123
145embryonic hemopoiesis (GO:0035162)2.73376135
146regulation of necrotic cell death (GO:0010939)2.72629694
147T cell homeostasis (GO:0043029)2.72598083
148pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.72193619
149leukocyte degranulation (GO:0043299)2.72129779
150DNA ligation (GO:0006266)2.71842360
151regulation of mast cell activation (GO:0033003)2.71720320
152porphyrin-containing compound biosynthetic process (GO:0006779)2.71419309
153monoamine transport (GO:0015844)2.71294073
154regulation of mast cell degranulation (GO:0043304)2.70869480
155DNA strand elongation (GO:0022616)2.70749482
156positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.70047602
157beta-amyloid metabolic process (GO:0050435)2.69941567
158reverse cholesterol transport (GO:0043691)2.69862157
159positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.69773977
160motile cilium assembly (GO:0044458)2.69686230
161guanosine-containing compound biosynthetic process (GO:1901070)2.69657171
162pyrimidine nucleoside catabolic process (GO:0046135)2.69540343
163positive regulation of megakaryocyte differentiation (GO:0045654)2.69320514
164oxidative phosphorylation (GO:0006119)2.69051617
165regulation of receptor recycling (GO:0001919)2.68980584
166positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.68308636
167mucosal immune response (GO:0002385)2.68264089
168organelle membrane fusion (GO:0090174)2.68100336
169telomere maintenance via recombination (GO:0000722)2.67883095
170mast cell activation (GO:0045576)2.67518958
171negative regulation of heart contraction (GO:0045822)2.66551917
172negative regulation of T cell apoptotic process (GO:0070233)2.66355883
173amine catabolic process (GO:0009310)2.66325373
174cellular biogenic amine catabolic process (GO:0042402)2.66325373
175peptide catabolic process (GO:0043171)2.66228948
176signal peptide processing (GO:0006465)2.65359043
177hepatocyte apoptotic process (GO:0097284)2.64795264
178antimicrobial humoral response (GO:0019730)2.64498844
179positive regulation of T cell mediated cytotoxicity (GO:0001916)2.64352197
180regulation of norepinephrine secretion (GO:0014061)2.64101956
181purine-containing compound salvage (GO:0043101)2.64057186
182cyclooxygenase pathway (GO:0019371)2.63610804
183DNA topological change (GO:0006265)2.63272745
184cardiolipin metabolic process (GO:0032048)2.62977619
185regulation of Golgi to plasma membrane protein transport (GO:0042996)2.62164455
186regulation of regulatory T cell differentiation (GO:0045589)2.61237270
187metallo-sulfur cluster assembly (GO:0031163)2.59653947
188iron-sulfur cluster assembly (GO:0016226)2.59653947
189regulation of mast cell activation involved in immune response (GO:0033006)2.59012266
190negative regulation of stress fiber assembly (GO:0051497)2.58548894
191cellular response to zinc ion (GO:0071294)2.58392544
192cellular biogenic amine biosynthetic process (GO:0042401)2.58369043
193amine biosynthetic process (GO:0009309)2.58361477
194regulation of T cell mediated cytotoxicity (GO:0001914)2.57020711
195pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.56110875

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SCL_19346495_ChIP-Seq_HPC-7_Human4.21545231
2SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human4.07173133
3E2F7_22180533_ChIP-Seq_HELA_Human3.91786534
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.77444699
5GATA1_22025678_ChIP-Seq_K562_Human3.73025543
6SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse3.18123393
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.98880248
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.94766069
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.91692700
10GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.86149496
11GATA2_19941826_ChIP-Seq_K562_Human2.85254973
12RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.83483970
13TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.71659258
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.65828270
15FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.63975542
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.57085949
17LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.48751210
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.47897003
19GABP_17652178_ChIP-ChIP_JURKAT_Human2.34944398
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.33374279
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.25471721
22MYB_21317192_ChIP-Seq_ERMYB_Mouse2.25110146
23GATA1_22383799_ChIP-Seq_G1ME_Mouse2.15794768
24ERG_20887958_ChIP-Seq_HPC-7_Mouse2.14849616
25HOXB4_20404135_ChIP-ChIP_EML_Mouse2.12200239
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.09602888
27VDR_23849224_ChIP-Seq_CD4+_Human2.07753865
28SRF_21415370_ChIP-Seq_HL-1_Mouse2.07123322
29STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.06039388
30VDR_21846776_ChIP-Seq_THP-1_Human2.01793021
31EST1_17652178_ChIP-ChIP_JURKAT_Human2.01623855
32GATA2_21666600_ChIP-Seq_HMVEC_Human2.00198919
33PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.98191449
34LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.96643436
35JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.94936250
36SPI1_23547873_ChIP-Seq_NB4_Human1.92814175
37GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.92092849
38MYC_18358816_ChIP-ChIP_MESCs_Mouse1.90246373
39SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.88811075
40TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.86578822
41ETS1_20019798_ChIP-Seq_JURKAT_Human1.86507309
42KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.85422779
43FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.84477597
44E2F4_17652178_ChIP-ChIP_JURKAT_Human1.82956811
45NOTCH1_21737748_ChIP-Seq_TLL_Human1.76543131
46MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.76285249
47RUNX1_22412390_ChIP-Seq_EML_Mouse1.76133562
48FOXP3_21729870_ChIP-Seq_TREG_Human1.75207517
49GATA1_19941827_ChIP-Seq_MEL_Mouse1.72601905
50Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.70993960
51GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.65783247
52HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.65261576
53IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.63262496
54KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.59790584
55CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.59740273
56GATA2_22383799_ChIP-Seq_G1ME_Mouse1.59075137
57IKZF1_21737484_ChIP-ChIP_HCT116_Human1.59029895
58XRN2_22483619_ChIP-Seq_HELA_Human1.58985664
59FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.56684623
60STAT4_19710469_ChIP-ChIP_TH1__Mouse1.56013409
61MYB_26560356_Chip-Seq_TH2_Human1.53341865
62VDR_24763502_ChIP-Seq_THP-1_Human1.53027156
63FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.52967788
64PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.51849312
65MYC_22102868_ChIP-Seq_BL_Human1.50779985
66MYC_19030024_ChIP-ChIP_MESCs_Mouse1.50570955
67CDX2_19796622_ChIP-Seq_MESCs_Mouse1.49103999
68EZH2_22144423_ChIP-Seq_EOC_Human1.47859140
69SRY_22984422_ChIP-ChIP_TESTIS_Rat1.47749127
70CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.45677525
71E2F1_18555785_ChIP-Seq_MESCs_Mouse1.42900577
72CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.39441831
73CREB1_15753290_ChIP-ChIP_HEK293T_Human1.38917558
74MAF_26560356_Chip-Seq_TH1_Human1.38870384
75GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.37027815
76VDR_22108803_ChIP-Seq_LS180_Human1.36314081
77ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.35012280
78RUNX_20019798_ChIP-Seq_JUKART_Human1.33174837
79DCP1A_22483619_ChIP-Seq_HELA_Human1.32207378
80BP1_19119308_ChIP-ChIP_Hs578T_Human1.32048316
81GATA4_25053715_ChIP-Seq_YYC3_Human1.31845837
82EGR1_23403033_ChIP-Seq_LIVER_Mouse1.31230693
83ELK4_26923725_Chip-Seq_MESODERM_Mouse1.30349476
84STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.29352933
85ELK1_19687146_ChIP-ChIP_HELA_Human1.29335837
86GATA1_19941827_ChIP-Seq_MEL86_Mouse1.26620962
87STAT1_20625510_ChIP-Seq_HELA_Human1.23864968
88MYB_26560356_Chip-Seq_TH1_Human1.23847829
89TTF2_22483619_ChIP-Seq_HELA_Human1.23454527
90FOXM1_23109430_ChIP-Seq_U2OS_Human1.23445305
91HTT_18923047_ChIP-ChIP_STHdh_Human1.20946669
92MYC_19079543_ChIP-ChIP_MESCs_Mouse1.20823183
93BRD4_27068464_Chip-Seq_AML-cells_Mouse1.16369772
94NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.15829058
95PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.15268260
96NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.14797980
97GABP_19822575_ChIP-Seq_HepG2_Human1.13722487
98IRF8_21731497_ChIP-ChIP_J774_Mouse1.13499727
99NANOG_20526341_ChIP-Seq_ESCs_Human1.13186372
100VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.12603282
101CIITA_25753668_ChIP-Seq_RAJI_Human1.11683993
102UTX_26944678_Chip-Seq_JUKART_Human1.11443705
103SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.10458191
104FOXO3_23340844_ChIP-Seq_DLD1_Human1.09806783
105NELFA_20434984_ChIP-Seq_ESCs_Mouse1.09101944
106BCL6_27268052_Chip-Seq_Bcells_Human1.08669811
107DROSHA_22980978_ChIP-Seq_HELA_Human1.08143818
108IRF8_27001747_Chip-Seq_BMDM_Mouse1.06540122
109BCOR_27268052_Chip-Seq_Bcells_Human1.06461242
110CEBPB_22108803_ChIP-Seq_LS180_Human1.06454576
111EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.06042631
112GATA3_21878914_ChIP-Seq_MCF-7_Human1.05691529
113PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05363147
114GBX2_23144817_ChIP-Seq_PC3_Human1.05112202
115PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04914363
116FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02271764
117SMRT_27268052_Chip-Seq_Bcells_Human1.02154525
118PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.01998541
119SPI1_20517297_ChIP-Seq_HL60_Human1.01886769
120E2F1_21310950_ChIP-Seq_MCF-7_Human1.01453927
121MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.00835492
122GATA1_19941826_ChIP-Seq_K562_Human0.99728014
123P300_27268052_Chip-Seq_Bcells_Human0.99297759
124NCOR1_26117541_ChIP-Seq_K562_Human0.98820452
125TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98782971
126EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.98473671
127FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.98296189
128PU.1_20513432_ChIP-Seq_Bcells_Mouse0.97610128
129SOX2_20726797_ChIP-Seq_SW620_Human0.97310952
130ZFX_18555785_ChIP-Seq_MESCs_Mouse0.97095879
131RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.96826949
132MAF_26560356_Chip-Seq_TH2_Human0.96330575
133ETS1_22383799_ChIP-Seq_G1ME_Mouse0.96108830
134CDX2_20551321_ChIP-Seq_CACO-2_Human0.95771658
135OCT1_27270436_Chip-Seq_PROSTATE_Human0.94622258
136GATA3_26560356_Chip-Seq_TH2_Human0.94485101
137CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.94422037
138GATA3_27048872_Chip-Seq_THYMUS_Human0.93487678
139SPI1_23127762_ChIP-Seq_K562_Human0.93224448
140PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.93040854
141E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.92360754
142SOX2_27498859_Chip-Seq_STOMACH_Mouse0.92177600
143RBPJ_22232070_ChIP-Seq_NCS_Mouse0.91635840
144FOXA1_25329375_ChIP-Seq_VCAP_Human0.91537962
145FOXA1_27270436_Chip-Seq_PROSTATE_Human0.91537962
146MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.91391542
147FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90981991
148RXR_22158963_ChIP-Seq_LIVER_Mouse0.90829168
149PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.90730984
150ESR1_21235772_ChIP-Seq_MCF-7_Human0.90689236
151TCF7_22412390_ChIP-Seq_EML_Mouse0.90645379
152YY1_22570637_ChIP-Seq_MALME-3M_Human0.90377176
153ERG_20517297_ChIP-Seq_VCAP_Human0.89254776
154GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87837644
155EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.87018488
156ESR1_20079471_ChIP-ChIP_T-47D_Human0.86585353
157RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.86296191
158GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.85825654
159TDRD3_21172665_ChIP-Seq_MCF-7_Human0.84310728
160PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.83925583
161TAF2_19829295_ChIP-Seq_ESCs_Human0.83336848
162STAT6_21828071_ChIP-Seq_BEAS2B_Human0.83269980
163LXR_22158963_ChIP-Seq_LIVER_Mouse0.82108940
164RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80516127
165CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.80437746
166TP63_22573176_ChIP-Seq_HFKS_Human0.79812661
167NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.78713530
168NRF2_20460467_ChIP-Seq_MEFs_Mouse0.78713530
169TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.78605485
170AR_20517297_ChIP-Seq_VCAP_Human0.78129330
171TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.78007997
172ARNT_22903824_ChIP-Seq_MCF-7_Human0.77608688
173ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.76791282

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003656_abnormal_erythrocyte_physiolo4.22841038
2MP0004147_increased_porphyrin_level4.16211605
3MP0002396_abnormal_hematopoietic_system3.74778293
4MP0005083_abnormal_biliary_tract3.55446860
5MP0005397_hematopoietic_system_phenotyp3.05672737
6MP0001545_abnormal_hematopoietic_system3.05672737
7MP0001835_abnormal_antigen_presentation2.90217365
8MP0000685_abnormal_immune_system2.74057008
9MP0003303_peritoneal_inflammation2.72865180
10MP0006054_spinal_hemorrhage2.72197388
11MP0001873_stomach_inflammation2.63255362
12MP0003724_increased_susceptibility_to2.49702513
13MP0009785_altered_susceptibility_to2.38946045
14MP0005464_abnormal_platelet_physiology2.34812913
15MP0000465_gastrointestinal_hemorrhage2.31796637
16MP0009379_abnormal_foot_pigmentation2.27727747
17MP0001986_abnormal_taste_sensitivity2.16699552
18MP0008872_abnormal_physiological_respon2.15928566
19MP0005671_abnormal_response_to2.12111304
20MP0004808_abnormal_hematopoietic_stem2.10644901
21MP0002653_abnormal_ependyma_morphology2.09027415
22MP0002398_abnormal_bone_marrow2.02242159
23MP0005025_abnormal_response_to1.98011659
24MP0002148_abnormal_hypersensitivity_rea1.92212060
25MP0003186_abnormal_redox_activity1.91547562
26MP0002166_altered_tumor_susceptibility1.89232661
27MP0000230_abnormal_systemic_arterial1.89158523
28MP0005174_abnormal_tail_pigmentation1.85317204
29MP0005167_abnormal_blood-brain_barrier1.83241113
30MP0000490_abnormal_crypts_of1.82495679
31MP0005075_abnormal_melanosome_morpholog1.80639412
32MP0000689_abnormal_spleen_morphology1.76589169
33MP0003693_abnormal_embryo_hatching1.76509683
34MP0003879_abnormal_hair_cell1.74770329
35MP0002420_abnormal_adaptive_immunity1.72277271
36MP0001800_abnormal_humoral_immune1.70764103
37MP0001819_abnormal_immune_cell1.70446952
38MP0003436_decreased_susceptibility_to1.69620119
39MP0002723_abnormal_immune_serum1.69279315
40MP0001853_heart_inflammation1.67751288
41MP0002722_abnormal_immune_system1.67096968
42MP0002419_abnormal_innate_immunity1.66928187
43MP0003638_abnormal_response/metabolism_1.66055952
44MP0002452_abnormal_antigen_presenting1.65520824
45MP0003806_abnormal_nucleotide_metabolis1.63835555
46MP0002132_abnormal_respiratory_system1.61263414
47MP0005000_abnormal_immune_tolerance1.61081003
48MP0002429_abnormal_blood_cell1.57933223
49MP0005410_abnormal_fertilization1.57426754
50MP0002095_abnormal_skin_pigmentation1.54527557
51MP0000716_abnormal_immune_system1.54442384
52MP0003763_abnormal_thymus_physiology1.52511734
53MP0002736_abnormal_nociception_after1.50312851
54MP0010155_abnormal_intestine_physiology1.46397445
55MP0010094_abnormal_chromosome_stability1.45865884
56MP0002006_tumorigenesis1.42845883
57MP0008058_abnormal_DNA_repair1.42215534
58MP0003941_abnormal_skin_development1.41693370
59MP0001851_eye_inflammation1.40895558
60MP0006036_abnormal_mitochondrial_physio1.40601934
61MP0001765_abnormal_ion_homeostasis1.38159881
62MP0002405_respiratory_system_inflammati1.36012235
63MP0001664_abnormal_digestion1.34057576
64MP0010329_abnormal_lipoprotein_level1.29269873
65MP0000015_abnormal_ear_pigmentation1.27534315
66MP0001845_abnormal_inflammatory_respons1.26017047
67MP0003866_abnormal_defecation1.24632232
68MP0008469_abnormal_protein_level1.23690173
69MP0004510_myositis1.23622716
70MP0005365_abnormal_bile_salt1.23468172
71MP0008007_abnormal_cellular_replicative1.23122012
72MP0008875_abnormal_xenobiotic_pharmacok1.22977423
73MP0001790_abnormal_immune_system1.18545660
74MP0005387_immune_system_phenotype1.18545660
75MP0000249_abnormal_blood_vessel1.17758617
76MP0001756_abnormal_urination1.15346223
77MP0001968_abnormal_touch/_nociception1.13072675
78MP0001663_abnormal_digestive_system1.11131535
79MP0003828_pulmonary_edema1.10914213
80MP0004130_abnormal_muscle_cell1.10643533
81MP0003566_abnormal_cell_adhesion1.10034620
82MP0004947_skin_inflammation1.09795033
83MP0002009_preneoplasia1.09257457
84MP0008004_abnormal_stomach_pH1.09188133
85MP0002733_abnormal_thermal_nociception1.09043664
86MP0009764_decreased_sensitivity_to1.08419014
87MP0009763_increased_sensitivity_to1.07922260
88MP0000383_abnormal_hair_follicle1.07900867
89MP0005646_abnormal_pituitary_gland1.07645732
90MP0000343_altered_response_to1.07477849
91MP0008057_abnormal_DNA_replication1.03572522
92MP0000703_abnormal_thymus_morphology1.03539706
93MP0009333_abnormal_splenocyte_physiolog1.03438940
94MP0005381_digestive/alimentary_phenotyp1.01283745
95MP0000749_muscle_degeneration1.01237022
96MP0009642_abnormal_blood_homeostasis0.98303725
97MP0005501_abnormal_skin_physiology0.97349488
98MP0005636_abnormal_mineral_homeostasis0.95834767
99MP0003077_abnormal_cell_cycle0.95332895
100MP0003183_abnormal_peptide_metabolism0.94879501
101MP0002019_abnormal_tumor_incidence0.93828385
102MP0008775_abnormal_heart_ventricle0.93660748
103MP0002933_joint_inflammation0.93286698
104MP0005085_abnormal_gallbladder_physiolo0.92379252
105MP0008874_decreased_physiological_sensi0.91778174
106MP0005379_endocrine/exocrine_gland_phen0.90993604
107MP0009765_abnormal_xenobiotic_induced0.90775013
108MP0001970_abnormal_pain_threshold0.90649401
109MP0003943_abnormal_hepatobiliary_system0.90454535
110MP0004215_abnormal_myocardial_fiber0.89179216
111MP0001533_abnormal_skeleton_physiology0.89049107
112MP0002928_abnormal_bile_duct0.86849103
113MP0003646_muscle_fatigue0.86477715
114MP0002136_abnormal_kidney_physiology0.85843475
115MP0009780_abnormal_chondrocyte_physiolo0.85517358
116MP0006082_CNS_inflammation0.83989097
117MP0003011_delayed_dark_adaptation0.83672027
118MP0001764_abnormal_homeostasis0.83070148
119MP0004957_abnormal_blastocyst_morpholog0.82761801
120MP0000372_irregular_coat_pigmentation0.81378828
121MP0003567_abnormal_fetal_cardiomyocyte0.80968615
122MP0002118_abnormal_lipid_homeostasis0.80619724
123MP0009278_abnormal_bone_marrow0.79963974
124MP0005535_abnormal_body_temperature0.79669354
125MP0005058_abnormal_lysosome_morphology0.79300784
126MP0000313_abnormal_cell_death0.78345445
127MP0001879_abnormal_lymphatic_vessel0.78209771
128MP0004084_abnormal_cardiac_muscle0.75024051
129MP0005165_increased_susceptibility_to0.74805769
130MP0003191_abnormal_cellular_cholesterol0.74434284
131MP0004019_abnormal_vitamin_homeostasis0.73931736
132MP0002796_impaired_skin_barrier0.73885085
133MP0000858_altered_metastatic_potential0.72953933
134MP0001905_abnormal_dopamine_level0.69099070
135MP0005319_abnormal_enzyme/_coenzyme0.69037837
136MP0005584_abnormal_enzyme/coenzyme_acti0.68858168
137MP0005448_abnormal_energy_balance0.68089000
138MP0003453_abnormal_keratinocyte_physiol0.67849409
139MP0005377_hearing/vestibular/ear_phenot0.66189287
140MP0009931_abnormal_skin_appearance0.65738988
141MP0003075_altered_response_to0.65130602
142MP0009643_abnormal_urine_homeostasis0.63019264
143MP0004036_abnormal_muscle_relaxation0.62036492
144MP0004782_abnormal_surfactant_physiolog0.59801295
145MP0005084_abnormal_gallbladder_morpholo0.58675335

Predicted human phenotypes

RankGene SetZ-score
1Menorrhagia (HP:0000132)7.90830319
2Increased mean platelet volume (HP:0011877)7.46116670
3Abnormal platelet volume (HP:0011876)7.08052140
4Abnormality of cells of the erythroid lineage (HP:0012130)6.70766131
5Abnormal number of erythroid precursors (HP:0012131)6.63681922
6Abnormality of the heme biosynthetic pathway (HP:0010472)6.38266319
7Gingival bleeding (HP:0000225)5.06080464
8Aplastic anemia (HP:0001915)4.90304085
9Hyperlipoproteinemia (HP:0010980)4.73202518
10Petechiae (HP:0000967)4.50308742
11Dynein arm defect of respiratory motile cilia (HP:0012255)4.23694341
12Absent/shortened dynein arms (HP:0200106)4.23694341
13Reticulocytopenia (HP:0001896)4.09450914
14Thrombocytosis (HP:0001894)4.08797078
15Chronic otitis media (HP:0000389)3.98035246
16Prolonged bleeding time (HP:0003010)3.96647181
17Dyschromatopsia (HP:0007641)3.68964630
18IgM deficiency (HP:0002850)3.62045612
19Spontaneous hematomas (HP:0007420)3.61452215
20Paralysis (HP:0003470)3.59085541
21Recurrent abscess formation (HP:0002722)3.58795741
22Pallor (HP:0000980)3.55081831
23Reduced antithrombin III activity (HP:0001976)3.38305481
24Nasal polyposis (HP:0100582)3.23448153
25Recurrent bacterial skin infections (HP:0005406)3.21837317
26Abnormality of the nasal mucosa (HP:0000433)3.18309810
27Elevated erythrocyte sedimentation rate (HP:0003565)3.15499559
28Decreased activity of mitochondrial respiratory chain (HP:0008972)3.07112454
29Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.07112454
30Decreased central vision (HP:0007663)3.04379112
31Type I transferrin isoform profile (HP:0003642)2.91978023
32Poikiloderma (HP:0001029)2.89125116
33Generalized aminoaciduria (HP:0002909)2.85488913
34Entropion (HP:0000621)2.84445408
35Macrocytic anemia (HP:0001972)2.82492404
36Rhinitis (HP:0012384)2.81164679
37Epistaxis (HP:0000421)2.80374940
38Conjunctival telangiectasia (HP:0000524)2.71927894
39Bruising susceptibility (HP:0000978)2.71606338
40Muscle fiber atrophy (HP:0100295)2.69999931
41Type 2 muscle fiber atrophy (HP:0003554)2.68689973
42Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.63675894
43Abnormal respiratory motile cilium physiology (HP:0012261)2.58837697
44Hypochromic microcytic anemia (HP:0004840)2.58515270
45Abnormal platelet function (HP:0011869)2.57687528
46Impaired platelet aggregation (HP:0003540)2.57687528
47Abnormal pupillary function (HP:0007686)2.54245818
48Increased density of long bones (HP:0006392)2.53806396
49Hepatic necrosis (HP:0002605)2.51875962
50Ventricular fibrillation (HP:0001663)2.51243706
51Increased serum ferritin (HP:0003281)2.50109321
52True hermaphroditism (HP:0010459)2.44207817
53Cellulitis (HP:0100658)2.43975439
54Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.42920229
55Abnormal protein N-linked glycosylation (HP:0012347)2.42920229
56Abnormal protein glycosylation (HP:0012346)2.42920229
57Abnormal glycosylation (HP:0012345)2.42920229
58Male infertility (HP:0003251)2.41363925
59Abnormal ciliary motility (HP:0012262)2.39007240
60Abnormality of the vasculature of the conjunctiva (HP:0008054)2.37912792
61Myositis (HP:0100614)2.37319684
62Pancytopenia (HP:0001876)2.33779562
63Abnormality of reticulocytes (HP:0004312)2.28984457
64Infertility (HP:0000789)2.28120020
65Stomatitis (HP:0010280)2.27981394
66Abnormal respiratory motile cilium morphology (HP:0005938)2.27573088
67Abnormal respiratory epithelium morphology (HP:0012253)2.27573088
68Joint swelling (HP:0001386)2.25506997
6911 pairs of ribs (HP:0000878)2.25379534
70Neoplasm of head and neck (HP:0012288)2.25293211
71Esophageal neoplasm (HP:0100751)2.25293211
72Hypothermia (HP:0002045)2.25121762
73Nausea (HP:0002018)2.24684180
74Abnormal hemoglobin (HP:0011902)2.20100704
75Hepatocellular necrosis (HP:0001404)2.19638059
76Poikilocytosis (HP:0004447)2.18446684
77Chronic bronchitis (HP:0004469)2.17392359
78Encephalitis (HP:0002383)2.15326848
79Increased IgM level (HP:0003496)2.15165494
80Microcytic anemia (HP:0001935)2.14343751
81Erythema (HP:0010783)2.14289146
82Ileus (HP:0002595)2.14138960
83Abnormality of DNA repair (HP:0003254)2.13923599
84Hepatosplenomegaly (HP:0001433)2.13273459
85Polycythemia (HP:0001901)2.13261772
86Broad face (HP:0000283)2.12108396
87Mitochondrial inheritance (HP:0001427)2.11059293
88Bronchiectasis (HP:0002110)2.10704615
89Exertional dyspnea (HP:0002875)2.10061031
90Increased hepatocellular lipid droplets (HP:0006565)2.09986679
91Eczematoid dermatitis (HP:0000976)2.09121870
92Abnormality of iron homeostasis (HP:0011031)2.08292376
93Lipid accumulation in hepatocytes (HP:0006561)2.08250826
94Purpura (HP:0000979)2.07366515
95Tongue fasciculations (HP:0001308)2.07176617
96Myelodysplasia (HP:0002863)2.06551582
97Xanthomatosis (HP:0000991)2.05013906
983-Methylglutaconic aciduria (HP:0003535)2.03719220
99Absent rod-and cone-mediated responses on ERG (HP:0007688)2.03636251
100Aplasia/Hypoplasia of the sacrum (HP:0008517)2.01627301
101Muscle fibrillation (HP:0010546)2.01452836
102Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.00524017
103Chronic sinusitis (HP:0011109)2.00144541
104Recurrent viral infections (HP:0004429)1.99706656
105Panhypogammaglobulinemia (HP:0003139)1.99553522
106Abnormality of macrophages (HP:0004311)1.98313257
107Abnormal auditory evoked potentials (HP:0006958)1.98034543
108Bronchitis (HP:0012387)1.97134425
109Increased muscle lipid content (HP:0009058)1.93778347
110Increased intramyocellular lipid droplets (HP:0012240)1.91802326
111Abnormality of the common coagulation pathway (HP:0010990)1.91054238
112Metaphyseal dysplasia (HP:0100255)1.89998355
113Asplenia (HP:0001746)1.89519856
114Abnormality of the prostate (HP:0008775)1.88740615
115Interstitial pulmonary disease (HP:0006530)1.88231267
116Pancreatic fibrosis (HP:0100732)1.86622053
117Recurrent skin infections (HP:0001581)1.86170759
118Increased serum lactate (HP:0002151)1.84821876
119Constricted visual fields (HP:0001133)1.84386845
120Recurrent bronchitis (HP:0002837)1.83629136
121Recurrent sinusitis (HP:0011108)1.82929992
122Hyperthyroidism (HP:0000836)1.82478966
123Chronic obstructive pulmonary disease (HP:0006510)1.82374407
124Obstructive lung disease (HP:0006536)1.82374407
125Increased CSF lactate (HP:0002490)1.82350883
126Hyperbilirubinemia (HP:0002904)1.81704937
127Acanthocytosis (HP:0001927)1.81580505
128Lactic acidosis (HP:0003128)1.80554128
129Cutaneous photosensitivity (HP:0000992)1.79106712
130Microretrognathia (HP:0000308)1.78299987
131Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.76903487
132Tinnitus (HP:0000360)1.74155615
133Biliary tract neoplasm (HP:0100574)1.73823396
134Upper limb muscle weakness (HP:0003484)1.73747606
135Exercise intolerance (HP:0003546)1.73273806
136Polyphagia (HP:0002591)1.72844859
137Hypochromic anemia (HP:0001931)1.72692452
138Hyperactive renin-angiotensin system (HP:0000841)1.72532719
139Abnormality of lateral ventricle (HP:0030047)1.72530475
140Abnormality of transition element cation homeostasis (HP:0011030)1.72383913
141Acute necrotizing encephalopathy (HP:0006965)1.72112095
142Reticulocytosis (HP:0001923)1.71834454
143Dicarboxylic aciduria (HP:0003215)1.70646486
144Decreased circulating renin level (HP:0003351)1.70311156
145Congenital sensorineural hearing impairment (HP:0008527)1.68041880
146Hypophosphatemic rickets (HP:0004912)1.66089987
147Thyroid-stimulating hormone excess (HP:0002925)1.65971477
148Dysautonomia (HP:0002459)1.65817944
149Metabolic alkalosis (HP:0200114)1.65570053
150Vertigo (HP:0002321)1.64561973
151Basal ganglia calcification (HP:0002135)1.63007385
152Episodic fever (HP:0001954)1.58439337
153Muscle fiber splitting (HP:0003555)1.57436990
154Inflammation of the large intestine (HP:0002037)1.54048213
155Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.54000609
156Joint hemorrhage (HP:0005261)1.51807308
157Abnormality of the renal cortex (HP:0011035)1.50961262
158Arterial thrombosis (HP:0004420)1.49668293
159Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.49299391
160Severe visual impairment (HP:0001141)1.49129416
161Abnormality of renin-angiotensin system (HP:0000847)1.47675383
162Abnormality of alanine metabolism (HP:0010916)1.43881800
163Hyperalaninemia (HP:0003348)1.43881800
164Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.43881800
165Central scotoma (HP:0000603)1.41587596
166Spontaneous abortion (HP:0005268)1.38215742
167Visual hallucinations (HP:0002367)1.36902708

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KIT4.22576082
2BMX3.70846411
3MAP2K33.39701867
4NME23.36537282
5EIF2AK13.04653303
6MAP4K13.02822588
7TEC2.84471969
8MAP3K32.74832060
9PTK2B2.74261796
10MUSK2.50071478
11GRK62.49542175
12FLT32.45912173
13PIM22.41521551
14STK162.41149661
15TAOK32.30918411
16MAPKAPK52.30814126
17BTK2.19155545
18TNIK2.11989347
19WEE12.06534849
20CDK192.04752511
21VRK11.89627461
22IRAK41.84329934
23RPS6KB21.75162921
24MAPKAPK31.74136018
25GRK51.67375649
26TBK11.55489727
27BRSK21.52095197
28DAPK21.51521087
29FRK1.50298743
30MYLK1.48569749
31EEF2K1.48242520
32SYK1.44819804
33FGR1.44307086
34DYRK31.40405657
35TIE11.38078289
36CSF1R1.32415825
37TGFBR21.31196671
38BMPR21.31111256
39MATK1.27679327
40TAOK11.27142766
41TGFBR11.24071936
42MAPK151.23396334
43PIK3CG1.23324369
44ACVR1B1.21901357
45MAP3K121.12507510
46ZAP701.11220877
47BLK1.10597656
48HCK1.07720345
49MST41.07693201
50MKNK11.05408183
51JAK31.04318256
52EPHA31.03641692
53TXK1.03105231
54RIPK41.02274477
55LRRK21.01884688
56ADRBK11.01680730
57CCNB10.99884480
58TYK20.99235506
59ZAK0.97233323
60MAP3K140.96175317
61STK30.96165907
62KDR0.95443011
63LMTK20.93781329
64ILK0.93655849
65DAPK30.93081626
66TRPM70.92729911
67PRKG20.91829123
68ERBB20.89988202
69TRIB30.89289232
70BMPR1B0.88969999
71BCKDK0.87112532
72SCYL20.86106613
73IKBKE0.83917598
74LYN0.83867921
75ADRBK20.83367291
76IRAK10.81627333
77IKBKB0.80559672
78PIM10.79962167
79CSK0.79725321
80TNK20.79253552
81MAP3K50.78794805
82GRK10.76151542
83STK100.75924654
84PINK10.73951895
85INSRR0.73677388
86FES0.73128809
87TESK20.72891444
88TAOK20.72471353
89CAMKK20.72159316
90MAP2K10.71581225
91RPS6KA60.71421934
92CDK80.70865439
93PKN20.70601580
94RPS6KL10.69939073
95RPS6KC10.69939073
96PRKD20.69697321
97PAK10.68426484
98MAPK40.62425742
99NEK90.61392340
100FER0.60790954
101MAP4K20.60570903
102RET0.60002280
103PRKD10.59578627
104BUB10.59072054
105CAMK10.58673910
106NEK20.58098319
107AURKB0.57789929
108ITK0.57522075
109MARK30.57424573
110DAPK10.56548896
111PDK10.55630788
112CDK70.55442044
113RPS6KA50.51876912
114PRKACG0.50759606
115MAP3K60.50675774
116STK240.50668543
117TLK10.50621388
118EPHB10.50480519
119LCK0.48828065
120OXSR10.48529209
121PDPK10.48471609
122CDC70.48417856
123MAPK110.48032487
124MAPKAPK20.47702087
125MAP3K110.47428320
126PRKCQ0.47361200
127PLK20.46003406
128MAP2K20.45819881
129PKN10.44879341
130RPS6KA20.44052701
131DYRK1B0.43831762
132STK40.43622356
133PAK20.43286034
134PAK30.42543765
135SIK30.42063578
136HIPK20.41832598
137ABL20.40742755
138BRSK10.39820935
139MAPK120.39044911
140PIK3CA0.38266477
141ERN10.37617713
142CDK40.37428338
143ATR0.37231286
144PRKCI0.36681412
145MAP2K60.36436083
146JAK20.36024757
147PRKCD0.35711152
148MAP3K10.35129593
149MAPK130.34702707
150PRKCA0.34074295
151FYN0.33916750
152PRKAA20.33736546
153SGK20.33119147
154NLK0.31417990
155OBSCN0.29641676

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.77255202
2DNA replication_Homo sapiens_hsa030304.46077571
3Base excision repair_Homo sapiens_hsa034102.59142740
4Nitrogen metabolism_Homo sapiens_hsa009102.53456431
5Mismatch repair_Homo sapiens_hsa034302.49707776
6Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.46327968
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.38048844
8RNA polymerase_Homo sapiens_hsa030202.35957353
9Proteasome_Homo sapiens_hsa030502.32697169
10Pyrimidine metabolism_Homo sapiens_hsa002402.29886610
11Parkinsons disease_Homo sapiens_hsa050122.20717569
12Nucleotide excision repair_Homo sapiens_hsa034202.12572267
13Homologous recombination_Homo sapiens_hsa034401.98091191
14Collecting duct acid secretion_Homo sapiens_hsa049661.88017878
15Protein export_Homo sapiens_hsa030601.80434463
16SNARE interactions in vesicular transport_Homo sapiens_hsa041301.73391860
17Oxidative phosphorylation_Homo sapiens_hsa001901.72676850
18Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.70271856
19Hematopoietic cell lineage_Homo sapiens_hsa046401.70210699
20Spliceosome_Homo sapiens_hsa030401.65953869
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.64685364
22Folate biosynthesis_Homo sapiens_hsa007901.62590377
23Vascular smooth muscle contraction_Homo sapiens_hsa042701.48063740
24Glycerolipid metabolism_Homo sapiens_hsa005611.44464547
25Chemokine signaling pathway_Homo sapiens_hsa040621.42679409
26Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.41709209
27Huntingtons disease_Homo sapiens_hsa050161.41246351
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.41027412
29Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.36725686
30Purine metabolism_Homo sapiens_hsa002301.36316027
31Serotonergic synapse_Homo sapiens_hsa047261.35205239
32Pancreatic secretion_Homo sapiens_hsa049721.35185832
33Chemical carcinogenesis_Homo sapiens_hsa052041.34919156
34Primary immunodeficiency_Homo sapiens_hsa053401.34280644
35Fat digestion and absorption_Homo sapiens_hsa049751.33513004
36Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.33262936
37Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.32354117
38Leishmaniasis_Homo sapiens_hsa051401.30466574
39RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.30022806
40Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.27795478
41Cell cycle_Homo sapiens_hsa041101.27665521
42Fanconi anemia pathway_Homo sapiens_hsa034601.26911395
43Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.26509934
44B cell receptor signaling pathway_Homo sapiens_hsa046621.25244569
45Glycerophospholipid metabolism_Homo sapiens_hsa005641.23734545
46Non-homologous end-joining_Homo sapiens_hsa034501.22084801
47Steroid hormone biosynthesis_Homo sapiens_hsa001401.16216495
48Sulfur metabolism_Homo sapiens_hsa009201.15705358
49Alzheimers disease_Homo sapiens_hsa050101.12750517
50ECM-receptor interaction_Homo sapiens_hsa045121.10332135
51Herpes simplex infection_Homo sapiens_hsa051681.10286302
52Other glycan degradation_Homo sapiens_hsa005111.09426235
53Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.07070662
54Platelet activation_Homo sapiens_hsa046111.04076966
55Starch and sucrose metabolism_Homo sapiens_hsa005001.03216876
56Pentose phosphate pathway_Homo sapiens_hsa000301.02220317
57Regulation of autophagy_Homo sapiens_hsa041401.00596649
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.00257443
59Arachidonic acid metabolism_Homo sapiens_hsa005900.99914792
60Ether lipid metabolism_Homo sapiens_hsa005650.99149235
61p53 signaling pathway_Homo sapiens_hsa041150.98839308
62Selenocompound metabolism_Homo sapiens_hsa004500.98240895
63Gap junction_Homo sapiens_hsa045400.95377757
64Endocytosis_Homo sapiens_hsa041440.94206253
65Measles_Homo sapiens_hsa051620.93812771
66Systemic lupus erythematosus_Homo sapiens_hsa053220.93424753
67Staphylococcus aureus infection_Homo sapiens_hsa051500.93215144
68Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.92315651
69Renin-angiotensin system_Homo sapiens_hsa046140.91394606
70Olfactory transduction_Homo sapiens_hsa047400.88742840
71Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.88651002
72Acute myeloid leukemia_Homo sapiens_hsa052210.87689913
73Phototransduction_Homo sapiens_hsa047440.85626106
74Graft-versus-host disease_Homo sapiens_hsa053320.85125002
75Antigen processing and presentation_Homo sapiens_hsa046120.84559052
76Intestinal immune network for IgA production_Homo sapiens_hsa046720.84280367
77Jak-STAT signaling pathway_Homo sapiens_hsa046300.83518277
78Transcriptional misregulation in cancer_Homo sapiens_hsa052020.82766775
79RNA degradation_Homo sapiens_hsa030180.81020466
80Autoimmune thyroid disease_Homo sapiens_hsa053200.80273509
81Sphingolipid metabolism_Homo sapiens_hsa006000.79242346
82N-Glycan biosynthesis_Homo sapiens_hsa005100.78182045
83Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.75338212
84Galactose metabolism_Homo sapiens_hsa000520.75148863
85Legionellosis_Homo sapiens_hsa051340.74934978
86Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.72754062
87NF-kappa B signaling pathway_Homo sapiens_hsa040640.72383554
88Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.72053466
89Retinol metabolism_Homo sapiens_hsa008300.72024145
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71727410
91Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.71574601
92Pertussis_Homo sapiens_hsa051330.70339937
93Glycosaminoglycan degradation_Homo sapiens_hsa005310.69668458
94Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.69605979
95Pentose and glucuronate interconversions_Homo sapiens_hsa000400.69314856
96Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68793687
97Choline metabolism in cancer_Homo sapiens_hsa052310.67874536
98Sulfur relay system_Homo sapiens_hsa041220.67645841
99T cell receptor signaling pathway_Homo sapiens_hsa046600.67278091
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66773122
101Phospholipase D signaling pathway_Homo sapiens_hsa040720.65847606
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.65787442
103Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63659121
104beta-Alanine metabolism_Homo sapiens_hsa004100.62786123
105Histidine metabolism_Homo sapiens_hsa003400.62616078
106Phagosome_Homo sapiens_hsa041450.62216731
107Long-term depression_Homo sapiens_hsa047300.61013951
108Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.60861784
109Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.60857986
110Caffeine metabolism_Homo sapiens_hsa002320.60855650
111PPAR signaling pathway_Homo sapiens_hsa033200.60745993
112Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.60653845
113Apoptosis_Homo sapiens_hsa042100.59282880
114Thyroid cancer_Homo sapiens_hsa052160.58796735
115Basal transcription factors_Homo sapiens_hsa030220.58200684
116Malaria_Homo sapiens_hsa051440.56863053
117Hepatitis B_Homo sapiens_hsa051610.55972604
118Circadian entrainment_Homo sapiens_hsa047130.55647761
119Allograft rejection_Homo sapiens_hsa053300.55074914
120Glutathione metabolism_Homo sapiens_hsa004800.54664719
121Bile secretion_Homo sapiens_hsa049760.52644325
122ABC transporters_Homo sapiens_hsa020100.52254485
123Epstein-Barr virus infection_Homo sapiens_hsa051690.51774893
124Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51669431
125Toll-like receptor signaling pathway_Homo sapiens_hsa046200.50626918
126Ovarian steroidogenesis_Homo sapiens_hsa049130.49896074
127Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.49831494
128Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.49640142
129Metabolic pathways_Homo sapiens_hsa011000.49610455
130Linoleic acid metabolism_Homo sapiens_hsa005910.49605851
131Morphine addiction_Homo sapiens_hsa050320.49351791
132Osteoclast differentiation_Homo sapiens_hsa043800.48979322
133Type I diabetes mellitus_Homo sapiens_hsa049400.48086326
134Peroxisome_Homo sapiens_hsa041460.47956280
135alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.47218696
136Renin secretion_Homo sapiens_hsa049240.45973091
137Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44073289
138Gastric acid secretion_Homo sapiens_hsa049710.44034077
139Alcoholism_Homo sapiens_hsa050340.43372730
140Influenza A_Homo sapiens_hsa051640.42689097
141Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.42305814
142Shigellosis_Homo sapiens_hsa051310.41794177
143Fatty acid biosynthesis_Homo sapiens_hsa000610.41745737
144Calcium signaling pathway_Homo sapiens_hsa040200.41535134
145Asthma_Homo sapiens_hsa053100.41228232
146Cardiac muscle contraction_Homo sapiens_hsa042600.40668522
147Toxoplasmosis_Homo sapiens_hsa051450.40197524
148Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37733318
149Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.37241284
150Tyrosine metabolism_Homo sapiens_hsa003500.37075388
151RNA transport_Homo sapiens_hsa030130.35984729
152Tuberculosis_Homo sapiens_hsa051520.35605887
153Ras signaling pathway_Homo sapiens_hsa040140.35213909
154Fatty acid degradation_Homo sapiens_hsa000710.35142488
155Mineral absorption_Homo sapiens_hsa049780.34709181
156Drug metabolism - other enzymes_Homo sapiens_hsa009830.31213951
157Leukocyte transendothelial migration_Homo sapiens_hsa046700.29450025
158Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.28862996
159Fatty acid elongation_Homo sapiens_hsa000620.28817474
160Viral carcinogenesis_Homo sapiens_hsa052030.28778186
161Propanoate metabolism_Homo sapiens_hsa006400.28679364
162Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.28462135

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