SMIM6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)7.38013309
2cellular ketone body metabolic process (GO:0046950)6.38102044
3ketone body metabolic process (GO:1902224)5.60359444
4sperm motility (GO:0030317)5.60103624
5acrosome reaction (GO:0007340)5.44966273
6axonemal dynein complex assembly (GO:0070286)5.24807073
7maintenance of gastrointestinal epithelium (GO:0030277)5.20338531
8phospholipid scrambling (GO:0017121)5.16202402
9surfactant homeostasis (GO:0043129)5.10786000
10regulation of type B pancreatic cell apoptotic process (GO:2000674)4.83673804
11platelet dense granule organization (GO:0060155)4.82224011
12regulation of cilium movement (GO:0003352)4.74716732
13response to pheromone (GO:0019236)4.67511905
14viral transcription (GO:0019083)4.65237998
15fucose catabolic process (GO:0019317)4.56214023
16L-fucose metabolic process (GO:0042354)4.56214023
17L-fucose catabolic process (GO:0042355)4.56214023
18SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.53324268
19translational termination (GO:0006415)4.48503367
20regulation of respiratory burst (GO:0060263)4.44298051
21cotranslational protein targeting to membrane (GO:0006613)4.40931546
22protein targeting to ER (GO:0045047)4.40044914
23erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.34652830
24L-phenylalanine catabolic process (GO:0006559)4.34652830
25epithelial cilium movement (GO:0003351)4.33051126
26protein localization to endoplasmic reticulum (GO:0070972)4.25911000
27fusion of sperm to egg plasma membrane (GO:0007342)4.23769852
28definitive hemopoiesis (GO:0060216)4.23640713
29cilium movement (GO:0003341)4.22202589
30L-phenylalanine metabolic process (GO:0006558)4.21191921
31erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.21191921
32positive regulation of respiratory burst (GO:0060267)4.19057347
33establishment of protein localization to endoplasmic reticulum (GO:0072599)4.15819843
34cilium or flagellum-dependent cell motility (GO:0001539)4.14942021
35sperm capacitation (GO:0048240)4.13640552
36protein targeting to Golgi (GO:0000042)4.02184002
37axoneme assembly (GO:0035082)3.98300105
38epithelial cell fate commitment (GO:0072148)3.96550530
39response to interferon-beta (GO:0035456)3.91722090
40establishment of protein localization to Golgi (GO:0072600)3.90847414
41negative regulation of transcription by competitive promoter binding (GO:0010944)3.87321557
42translational elongation (GO:0006414)3.86872419
43UDP-N-acetylglucosamine metabolic process (GO:0006047)3.85861515
44antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.85421919
45auditory receptor cell differentiation (GO:0042491)3.85128727
46calcium ion-dependent exocytosis (GO:0017156)3.82564005
47chemical homeostasis within a tissue (GO:0048875)3.81104888
48single strand break repair (GO:0000012)3.80186888
49endocrine pancreas development (GO:0031018)3.79930138
50insulin secretion (GO:0030073)3.77850320
51GDP-mannose metabolic process (GO:0019673)3.76933202
52digestion (GO:0007586)3.75648041
53phosphatidylethanolamine biosynthetic process (GO:0006646)3.73998061
54spermatid development (GO:0007286)3.73458293
55retrograde transport, vesicle recycling within Golgi (GO:0000301)3.73329512
56regulation of hexokinase activity (GO:1903299)3.69460786
57regulation of glucokinase activity (GO:0033131)3.69460786
58peptide catabolic process (GO:0043171)3.63189234
59ribosomal small subunit biogenesis (GO:0042274)3.61036608
60Golgi to endosome transport (GO:0006895)3.57368038
61multicellular organism reproduction (GO:0032504)3.56688676
62mature B cell differentiation involved in immune response (GO:0002313)3.56458433
63protein polyglutamylation (GO:0018095)3.55889072
64fucose metabolic process (GO:0006004)3.55515555
65viral life cycle (GO:0019058)3.54175568
66epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.52088342
67phosphatidylethanolamine metabolic process (GO:0046337)3.51600915
68O-glycan processing (GO:0016266)3.50381323
69L-alpha-amino acid transmembrane transport (GO:1902475)3.50285366
70inositol phosphate dephosphorylation (GO:0046855)3.47874113
71phosphorylated carbohydrate dephosphorylation (GO:0046838)3.47874113
72antigen processing and presentation via MHC class Ib (GO:0002475)3.45795923
73signal peptide processing (GO:0006465)3.43407121
74regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.41389505
75positive regulation of insulin secretion (GO:0032024)3.40789038
76bundle of His cell to Purkinje myocyte communication (GO:0086069)3.39979626
77protein localization to Golgi apparatus (GO:0034067)3.39882222
78inositol phosphate catabolic process (GO:0071545)3.39378878
79plasma membrane fusion (GO:0045026)3.36948646
80epithelial structure maintenance (GO:0010669)3.36024814
81cellular protein complex disassembly (GO:0043624)3.35794834
82retinol metabolic process (GO:0042572)3.34212670
83motile cilium assembly (GO:0044458)3.27703711
84calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.27302822
85nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.26235418
86leukotriene biosynthetic process (GO:0019370)3.25692415
87negative regulation of execution phase of apoptosis (GO:1900118)3.24901590
88positive regulation of glycolytic process (GO:0045821)3.23701946
89macroautophagy (GO:0016236)3.21640744
90organic cation transport (GO:0015695)3.20076814
91nitric oxide mediated signal transduction (GO:0007263)3.19061064
92xenobiotic catabolic process (GO:0042178)3.17869169
93protein localization to cilium (GO:0061512)3.17259122
94reproduction (GO:0000003)3.14111255
95DNA deamination (GO:0045006)3.12947609
96negative regulation of erythrocyte differentiation (GO:0045647)3.11468840
97protein autoprocessing (GO:0016540)3.11401400
98nitric oxide biosynthetic process (GO:0006809)3.10072656
99peptide hormone processing (GO:0016486)3.09355781
100positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.05694186
101brain morphogenesis (GO:0048854)3.03628118
102hepatocyte apoptotic process (GO:0097284)3.03182107
103water-soluble vitamin biosynthetic process (GO:0042364)3.02933614
104nucleotide-sugar metabolic process (GO:0009225)3.01683988
105regulation of proton transport (GO:0010155)2.99231661
106nucleotide-sugar biosynthetic process (GO:0009226)2.97888695
107positive regulation of peptide hormone secretion (GO:0090277)2.96679006
108purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.96498745
109protein complex disassembly (GO:0043241)2.95793835
110peptide hormone secretion (GO:0030072)2.95669742
111secretory granule organization (GO:0033363)2.95365353
112innate immune response in mucosa (GO:0002227)2.92801586
113translational initiation (GO:0006413)2.91511689
114positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.91207643
115regulation of protein glycosylation (GO:0060049)2.90300040
116sulfation (GO:0051923)2.89521434
117glycerophospholipid catabolic process (GO:0046475)2.87077535
118peptide secretion (GO:0002790)2.86854806
119cilium organization (GO:0044782)2.86115217
120endosome to pigment granule transport (GO:0043485)2.85715422
121endosome to melanosome transport (GO:0035646)2.85715422
122digestive system process (GO:0022600)2.85642569
123sperm-egg recognition (GO:0035036)2.84400041
124myeloid dendritic cell activation (GO:0001773)2.83749164
125protein targeting to membrane (GO:0006612)2.83633358
126positive regulation of peptide secretion (GO:0002793)2.83618320
127coenzyme catabolic process (GO:0009109)2.83539057
128regulation of autophagic vacuole assembly (GO:2000785)2.83457110
129glandular epithelial cell differentiation (GO:0002067)2.83370884
130lactate metabolic process (GO:0006089)2.83245469
131lung secretory cell differentiation (GO:0061140)2.83187786
132cilium assembly (GO:0042384)2.82709235
133antibacterial humoral response (GO:0019731)2.82366832
134mitochondrial calcium ion transport (GO:0006851)2.80779655
1353-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.80300626
136purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.80300626
137macromolecular complex disassembly (GO:0032984)2.79642834
138maturation of SSU-rRNA (GO:0030490)2.79506015
139antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.78458485
140antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.78458485
141respiratory chain complex IV assembly (GO:0008535)2.78336386
142regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.78283864
143positive regulation of Cdc42 GTPase activity (GO:0043089)2.77984887
144regulation of microtubule-based movement (GO:0060632)2.74384504
145cell wall macromolecule catabolic process (GO:0016998)2.74295826
146detection of bacterium (GO:0016045)2.73722824
147regulation of vacuole organization (GO:0044088)2.73263732
148spermatogenesis (GO:0007283)2.72494490
149zinc ion homeostasis (GO:0055069)2.72127515
150male gamete generation (GO:0048232)2.71531111
151antimicrobial humoral response (GO:0019730)2.71342921
152polyol catabolic process (GO:0046174)2.69645071
153single fertilization (GO:0007338)2.69569954
154negative regulation of neurological system process (GO:0031645)2.69248883
155intestinal absorption (GO:0050892)2.68218409
156phenylpropanoid metabolic process (GO:0009698)2.67394714
157response to interferon-alpha (GO:0035455)2.67348978
158regulation of metalloenzyme activity (GO:0048552)2.66002233
159protein O-linked glycosylation (GO:0006493)2.65335811
160leukotriene metabolic process (GO:0006691)2.63998461
161pattern specification involved in kidney development (GO:0061004)2.63611976
162detection of calcium ion (GO:0005513)2.62982959
163fucosylation (GO:0036065)2.61707900
164mucosal immune response (GO:0002385)2.60496791
165megakaryocyte development (GO:0035855)2.60171195
166inner ear receptor cell differentiation (GO:0060113)2.59657468
167cellular zinc ion homeostasis (GO:0006882)2.59197541
168purine-containing compound salvage (GO:0043101)2.58644711
169negative regulation of epidermal cell differentiation (GO:0045605)2.58345437
170nephron epithelium morphogenesis (GO:0072088)2.57741806
171nephron tubule morphogenesis (GO:0072078)2.57741806
172spermatid nucleus differentiation (GO:0007289)2.57656592
173mature B cell differentiation (GO:0002335)2.57020517
174regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.54719048
175positive regulation of gluconeogenesis (GO:0045722)2.54495313
176antigen processing and presentation of endogenous antigen (GO:0019883)2.54138269
177cytochrome complex assembly (GO:0017004)2.53952631
178negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.53781559
179regulation of Rab GTPase activity (GO:0032313)2.53498438
180positive regulation of Rab GTPase activity (GO:0032851)2.53498438
181regulation of acrosome reaction (GO:0060046)2.53472536
182detection of other organism (GO:0098543)2.52539820
183deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.52380675
184aromatic amino acid family catabolic process (GO:0009074)2.52120802
185sphingomyelin metabolic process (GO:0006684)2.52088412
186CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.51692922
187RNA destabilization (GO:0050779)2.51415910
188gamete generation (GO:0007276)2.50723355
189galactose catabolic process (GO:0019388)2.50559457
190peptide transport (GO:0015833)2.50117773
191protein retention in ER lumen (GO:0006621)2.49075920
192exocrine pancreas development (GO:0031017)2.48975087
193translation (GO:0006412)2.48526825
194autophagic vacuole fusion (GO:0000046)2.47404248
195defense response to protozoan (GO:0042832)2.47093301
196response to type I interferon (GO:0034340)2.46746181
197type I interferon signaling pathway (GO:0060337)2.46047975
198rRNA methylation (GO:0031167)2.45839535

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.50299906
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.15988846
3GATA1_22025678_ChIP-Seq_K562_Human4.02898947
4SCL_19346495_ChIP-Seq_HPC-7_Human3.45187658
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.35691168
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.02684869
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.73791269
8TP63_17297297_ChIP-ChIP_HaCaT_Human2.71331106
9SOX2_27498859_Chip-Seq_STOMACH_Mouse2.62005234
10RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.57598495
11STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.49560629
12CDX2_20551321_ChIP-Seq_CACO-2_Human2.41979206
13SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.36302549
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.32897049
15GBX2_23144817_ChIP-Seq_PC3_Human2.26644330
16GATA4_25053715_ChIP-Seq_YYC3_Human2.24197437
17TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.23160307
18FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.22803540
19TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.20865710
20EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.17565561
21LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.10724879
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.02766968
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.02187851
24CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.02095213
25EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.01275933
26SOX2_20726797_ChIP-Seq_SW620_Human1.95723775
27GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.90617053
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.89702398
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.85350767
30MYB_21317192_ChIP-Seq_ERMYB_Mouse1.84422176
31LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.83651180
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.83555459
33TAF15_26573619_Chip-Seq_HEK293_Human1.79980638
34ERG_20887958_ChIP-Seq_HPC-7_Mouse1.76721780
35CBP_20019798_ChIP-Seq_JUKART_Human1.76622995
36IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.76622995
37ESR1_21235772_ChIP-Seq_MCF-7_Human1.75366238
38HOXB4_20404135_ChIP-ChIP_EML_Mouse1.74654788
39MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.74174505
40CDX2_19796622_ChIP-Seq_MESCs_Mouse1.73579526
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.73394334
42FUS_26573619_Chip-Seq_HEK293_Human1.72989878
43BP1_19119308_ChIP-ChIP_Hs578T_Human1.72501680
44SMAD4_21799915_ChIP-Seq_A2780_Human1.71923458
45SPI1_23547873_ChIP-Seq_NB4_Human1.71153485
46AR_25329375_ChIP-Seq_VCAP_Human1.70285373
47E2F7_22180533_ChIP-Seq_HELA_Human1.69415782
48AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.69386896
49FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.67540876
50P300_19829295_ChIP-Seq_ESCs_Human1.66951671
51ER_23166858_ChIP-Seq_MCF-7_Human1.66799903
52GATA1_22383799_ChIP-Seq_G1ME_Mouse1.66685007
53STAT4_19710469_ChIP-ChIP_TH1__Mouse1.66546629
54IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.65838998
55PIAS1_25552417_ChIP-Seq_VCAP_Human1.62865722
56VDR_24763502_ChIP-Seq_THP-1_Human1.62399737
57ZNF217_24962896_ChIP-Seq_MCF-7_Human1.59078056
58EGR1_23403033_ChIP-Seq_LIVER_Mouse1.58000006
59ZNF274_21170338_ChIP-Seq_K562_Hela1.57862675
60ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.55039282
61HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.54382606
62SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.53888307
63GATA2_21666600_ChIP-Seq_HMVEC_Human1.53700745
64STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.53144953
65MYC_18555785_ChIP-Seq_MESCs_Mouse1.52789185
66GATA2_22383799_ChIP-Seq_G1ME_Mouse1.50966457
67ARNT_22903824_ChIP-Seq_MCF-7_Human1.50944895
68SMAD3_21741376_ChIP-Seq_EPCs_Human1.46119694
69ZFP57_27257070_Chip-Seq_ESCs_Mouse1.44139031
70FLI1_27457419_Chip-Seq_LIVER_Mouse1.43380810
71STAT3_23295773_ChIP-Seq_U87_Human1.43327724
72SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.42680746
73GATA6_25053715_ChIP-Seq_YYC3_Human1.42550833
74RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.41480621
75NANOG_18555785_Chip-Seq_ESCs_Mouse1.40763563
76BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.39188874
77FOXA1_27270436_Chip-Seq_PROSTATE_Human1.35649466
78FOXA1_25329375_ChIP-Seq_VCAP_Human1.35649466
79SMAD4_21741376_ChIP-Seq_EPCs_Human1.34565309
80PHF8_20622853_ChIP-Seq_HELA_Human1.34433386
81RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.34396616
82SRF_21415370_ChIP-Seq_HL-1_Mouse1.34125100
83CDX2_22108803_ChIP-Seq_LS180_Human1.34077541
84UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.33772200
85EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.33761783
86VDR_21846776_ChIP-Seq_THP-1_Human1.33036268
87MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.32585085
88HNFA_21074721_ChIP-Seq_CACO-2_Human1.30812545
89NANOG_19829295_ChIP-Seq_ESCs_Human1.30210000
90SOX2_19829295_ChIP-Seq_ESCs_Human1.30210000
91RBPJ_21746931_ChIP-Seq_IB4_Human1.29751788
92PCGF2_27294783_Chip-Seq_ESCs_Mouse1.27643282
93RUNX1_22412390_ChIP-Seq_EML_Mouse1.27226382
94TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.26730515
95STAT6_21828071_ChIP-Seq_BEAS2B_Human1.26352125
96TBL1_22424771_ChIP-Seq_293T_Human1.26035466
97NFYB_21822215_ChIP-Seq_K562_Human1.25323151
98PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.24916023
99MYB_26560356_Chip-Seq_TH2_Human1.23748699
100BMI1_23680149_ChIP-Seq_NPCS_Mouse1.22724758
101ETV2_25802403_ChIP-Seq_MESCs_Mouse1.22048549
102BCAT_22108803_ChIP-Seq_LS180_Human1.20747491
103TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19536266
104ETV1_20927104_ChIP-Seq_GIST48_Human1.19427539
105FOXA1_21572438_ChIP-Seq_LNCaP_Human1.19332821
106GATA1_19941827_ChIP-Seq_MEL_Mouse1.18416408
107TCF4_23295773_ChIP-Seq_U87_Human1.17511819
108NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17494178
109PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.17474315
110IRF8_21731497_ChIP-ChIP_J774_Mouse1.17222665
111FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.16628044
112FOXM1_26456572_ChIP-Seq_MCF-7_Human1.16401267
113CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.16332476
114NFYA_21822215_ChIP-Seq_K562_Human1.15106419
115SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14248251
116EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.13528646
117CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.12287197
118CBX2_22325352_ChIP-Seq_293T-Rex_Human1.12119813
119TCF4_22108803_ChIP-Seq_LS180_Human1.11803353
120STAT3_18555785_Chip-Seq_ESCs_Mouse1.11800805
121TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11390058
122NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.11361371
123MYC_19829295_ChIP-Seq_ESCs_Human1.11281216
124E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.11250947
125HTT_18923047_ChIP-ChIP_STHdh_Human1.11246717
126RUNX2_22187159_ChIP-Seq_PCA_Human1.11206647
127GATA3_21878914_ChIP-Seq_MCF-7_Human1.11075796
128AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.10918405
129VDR_22108803_ChIP-Seq_LS180_Human1.10826814
130SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.10805226
131P53_22387025_ChIP-Seq_ESCs_Mouse1.10559272
132MYB_26560356_Chip-Seq_TH1_Human1.10409280
133NFE2_27457419_Chip-Seq_LIVER_Mouse1.10215640
134KLF5_20875108_ChIP-Seq_MESCs_Mouse1.09821376
135AHR_22903824_ChIP-Seq_MCF-7_Human1.08934620
136E2F1_18555785_Chip-Seq_ESCs_Mouse1.08447941
137MYC_18358816_ChIP-ChIP_MESCs_Mouse1.08211864
138NCOR_22424771_ChIP-Seq_293T_Human1.07628517
139CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.07261723
140LXR_22158963_ChIP-Seq_LIVER_Mouse1.07184028
141SUZ12_18555785_Chip-Seq_ESCs_Mouse1.07132256
142SOX2_18555785_Chip-Seq_ESCs_Mouse1.06451042
143CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.06262154
144TP63_23658742_ChIP-Seq_EP156T_Human1.05929574
145TP53_22573176_ChIP-Seq_HFKS_Human1.05769440
146EZH2_27294783_Chip-Seq_NPCs_Mouse1.05424544
147STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.05235958
148NANOG_20526341_ChIP-Seq_ESCs_Human1.04387453
149CTCF_18555785_Chip-Seq_ESCs_Mouse1.04078293
150ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.03236150
151PPARA_22158963_ChIP-Seq_LIVER_Mouse1.03074482
152MAF_26560356_Chip-Seq_TH1_Human1.02531254
153NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.02023835
154OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01685947
155EST1_17652178_ChIP-ChIP_JURKAT_Human1.01315480
156FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.00992747
157ERG_20517297_ChIP-Seq_VCAP_Human1.00899873
158SMRT_27268052_Chip-Seq_Bcells_Human1.00704874
159SRY_22984422_ChIP-ChIP_TESTIS_Rat1.00491016
160TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.00383071
161GATA6_21074721_ChIP-Seq_CACO-2_Human1.00284794
162EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.00254821
163P300_18555785_Chip-Seq_ESCs_Mouse1.00222402
164HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.00034993
165RARG_19884340_ChIP-ChIP_MEFs_Mouse0.99861714
166TP53_18474530_ChIP-ChIP_U2OS_Human0.98949006
167KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.98912197
168SPI1_23127762_ChIP-Seq_K562_Human0.98550952
169VDR_23849224_ChIP-Seq_CD4+_Human0.98401032
170AR_20517297_ChIP-Seq_VCAP_Human0.98031561
171IRF8_27001747_Chip-Seq_BMDM_Mouse0.97320510
172FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.96830604
173P63_26484246_Chip-Seq_KERATINOCYTES_Human0.94026398
174NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.93764864
175BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.93428507
176E2F1_18555785_ChIP-Seq_MESCs_Mouse0.93234300
177BRD4_27068464_Chip-Seq_AML-cells_Mouse0.91876707
178ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.91798729
179FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.91619883
180PPAR_26484153_Chip-Seq_NCI-H1993_Human0.91177886
181SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.90815128
182ESR2_21235772_ChIP-Seq_MCF-7_Human0.90609811
183SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.90106118
184SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.90106118
185GATA2_19941826_ChIP-Seq_K562_Human0.89072477
186GATA3_27048872_Chip-Seq_THYMUS_Human0.88758219
187ELF5_23300383_ChIP-Seq_T47D_Human0.88631587
188BCL6_27268052_Chip-Seq_Bcells_Human0.88585563
189NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.87076588
190FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.85852438
191STAT3_1855785_ChIP-Seq_MESCs_Mouse0.85831406
192NOTCH1_21737748_ChIP-Seq_TLL_Human0.85544469
193JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.85535301
194GABP_17652178_ChIP-ChIP_JURKAT_Human0.84825466
195GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.84312366

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008004_abnormal_stomach_pH5.94352146
2MP0005410_abnormal_fertilization4.17882196
3MP0005379_endocrine/exocrine_gland_phen4.07852757
4MP0001666_abnormal_nutrient_absorption3.54595812
5MP0001873_stomach_inflammation3.54305142
6MP0004782_abnormal_surfactant_physiolog3.37289493
7MP0002837_dystrophic_cardiac_calcinosis3.37192875
8MP0003195_calcinosis3.25828824
9MP0009780_abnormal_chondrocyte_physiolo3.10779709
10MP0006054_spinal_hemorrhage3.04017431
11MP0002163_abnormal_gland_morphology3.02532502
12MP0010386_abnormal_urinary_bladder2.91074719
13MP0000490_abnormal_crypts_of2.81111090
14MP0002909_abnormal_adrenal_gland2.76892783
15MP0005083_abnormal_biliary_tract2.59818528
16MP0003866_abnormal_defecation2.57565512
17MP0010155_abnormal_intestine_physiology2.57393017
18MP0001664_abnormal_digestion2.54691771
19MP0001944_abnormal_pancreas_morphology2.43694209
20MP0004264_abnormal_extraembryonic_tissu2.39647688
21MP0003283_abnormal_digestive_organ2.31147709
22MP0003724_increased_susceptibility_to2.22445651
23MP0003787_abnormal_imprinting2.17277166
24MP0004019_abnormal_vitamin_homeostasis2.11422706
25MP0001835_abnormal_antigen_presentation2.08689266
26MP0005645_abnormal_hypothalamus_physiol2.08471536
27MP0000566_synostosis2.06721089
28MP0009379_abnormal_foot_pigmentation2.06386249
29MP0000685_abnormal_immune_system2.04603966
30MP0010329_abnormal_lipoprotein_level2.01125341
31MP0002254_reproductive_system_inflammat2.00258436
32MP0000013_abnormal_adipose_tissue1.97213983
33MP0003806_abnormal_nucleotide_metabolis1.95920415
34MP0001663_abnormal_digestive_system1.95402866
35MP0005646_abnormal_pituitary_gland1.93342561
36MP0003868_abnormal_feces_composition1.91183887
37MP0010234_abnormal_vibrissa_follicle1.87729646
38MP0000470_abnormal_stomach_morphology1.86695722
39MP0008877_abnormal_DNA_methylation1.84787508
40MP0001756_abnormal_urination1.82336891
41MP0005085_abnormal_gallbladder_physiolo1.76872205
42MP0009785_altered_susceptibility_to1.74971461
43MP0005332_abnormal_amino_acid1.70285014
44MP0001984_abnormal_olfaction1.67515234
45MP0003011_delayed_dark_adaptation1.67271645
46MP0002132_abnormal_respiratory_system1.64552403
47MP0003941_abnormal_skin_development1.64393726
48MP0003172_abnormal_lysosome_physiology1.62994075
49MP0002396_abnormal_hematopoietic_system1.59463179
50MP0003698_abnormal_male_reproductive1.59289844
51MP0005365_abnormal_bile_salt1.55860243
52MP0008875_abnormal_xenobiotic_pharmacok1.54723185
53MP0003122_maternal_imprinting1.54405930
54MP0005381_digestive/alimentary_phenotyp1.53794380
55MP0002078_abnormal_glucose_homeostasis1.52242183
56MP0009046_muscle_twitch1.51585168
57MP0005025_abnormal_response_to1.51559126
58MP0000465_gastrointestinal_hemorrhage1.50519077
59MP0005464_abnormal_platelet_physiology1.50372994
60MP0001958_emphysema1.50233040
61MP0005084_abnormal_gallbladder_morpholo1.48664584
62MP0005220_abnormal_exocrine_pancreas1.46676208
63MP0000477_abnormal_intestine_morphology1.46286765
64MP0009697_abnormal_copulation1.44784623
65MP0005397_hematopoietic_system_phenotyp1.41452271
66MP0001545_abnormal_hematopoietic_system1.41452271
67MP0003879_abnormal_hair_cell1.41386254
68MP0005551_abnormal_eye_electrophysiolog1.40010615
69MP0001929_abnormal_gametogenesis1.39981057
70MP0002166_altered_tumor_susceptibility1.39543548
71MP0005671_abnormal_response_to1.39110055
72MP0006072_abnormal_retinal_apoptosis1.38340488
73MP0010678_abnormal_skin_adnexa1.37673529
74MP0003943_abnormal_hepatobiliary_system1.37559936
75MP0002928_abnormal_bile_duct1.35400807
76MP0000003_abnormal_adipose_tissue1.33367996
77MP0004270_analgesia1.32146521
78MP0004147_increased_porphyrin_level1.30328333
79MP0002277_abnormal_respiratory_mucosa1.30159760
80MP0004133_heterotaxia1.29467474
81MP0002148_abnormal_hypersensitivity_rea1.28429326
82MP0003186_abnormal_redox_activity1.24549904
83MP0004808_abnormal_hematopoietic_stem1.24465197
84MP0005310_abnormal_salivary_gland1.23244312
85MP0003252_abnormal_bile_duct1.20444673
86MP0003763_abnormal_thymus_physiology1.19968787
87MP0001845_abnormal_inflammatory_respons1.16224908
88MP0005535_abnormal_body_temperature1.15814166
89MP0005174_abnormal_tail_pigmentation1.14792465
90MP0002006_tumorigenesis1.14082874
91MP0001905_abnormal_dopamine_level1.13547076
92MP0009643_abnormal_urine_homeostasis1.12881795
93MP0005387_immune_system_phenotype1.12678799
94MP0001790_abnormal_immune_system1.12678799
95MP0004043_abnormal_pH_regulation1.12568945
96MP0003191_abnormal_cellular_cholesterol1.11649037
97MP0000681_abnormal_thyroid_gland1.09081620
98MP0001800_abnormal_humoral_immune1.07264716
99MP0003953_abnormal_hormone_level1.06490281
100MP0000516_abnormal_urinary_system1.06130010
101MP0005367_renal/urinary_system_phenotyp1.06130010
102MP0002452_abnormal_antigen_presenting1.05097940
103MP0002118_abnormal_lipid_homeostasis1.05021550
104MP0002420_abnormal_adaptive_immunity1.04448344
105MP0003718_maternal_effect1.04276820
106MP0005636_abnormal_mineral_homeostasis1.04004287
107MP0002877_abnormal_melanocyte_morpholog1.03651241
108MP0002723_abnormal_immune_serum1.03356239
109MP0002638_abnormal_pupillary_reflex1.03340818
110MP0001819_abnormal_immune_cell1.02642321
111MP0002405_respiratory_system_inflammati1.00770722
112MP0002229_neurodegeneration1.00122418
113MP0005253_abnormal_eye_physiology0.99849436
114MP0005448_abnormal_energy_balance0.99088477
115MP0008995_early_reproductive_senescence0.98381464
116MP0010368_abnormal_lymphatic_system0.97957595
117MP0000372_irregular_coat_pigmentation0.97755809
118MP0000462_abnormal_digestive_system0.97499516
119MP0003183_abnormal_peptide_metabolism0.97386396
120MP0001501_abnormal_sleep_pattern0.97356927
121MP0001853_heart_inflammation0.95908980
122MP0005670_abnormal_white_adipose0.95639076
123MP0002098_abnormal_vibrissa_morphology0.95003556
124MP0002138_abnormal_hepatobiliary_system0.94363210
125MP0001986_abnormal_taste_sensitivity0.93599185
126MP0002139_abnormal_hepatobiliary_system0.93358765
127MP0008872_abnormal_physiological_respon0.92766968
128MP0001764_abnormal_homeostasis0.92535587
129MP0002398_abnormal_bone_marrow0.91457489
130MP0002095_abnormal_skin_pigmentation0.90957605
131MP0003300_gastrointestinal_ulcer0.88975062
132MP0005075_abnormal_melanosome_morpholog0.87874982
133MP0009745_abnormal_behavioral_response0.87567024
134MP0008469_abnormal_protein_level0.87396579
135MP0000639_abnormal_adrenal_gland0.87122761
136MP0004085_abnormal_heartbeat0.86918199
137MP0005377_hearing/vestibular/ear_phenot0.86205646
138MP0003878_abnormal_ear_physiology0.86205646
139MP0004947_skin_inflammation0.86180392
140MP0003693_abnormal_embryo_hatching0.85864971
141MP0000613_abnormal_salivary_gland0.85616579
142MP0000716_abnormal_immune_system0.85277176
143MP0001970_abnormal_pain_threshold0.85014627
144MP0002557_abnormal_social/conspecific_i0.84996403
145MP0005000_abnormal_immune_tolerance0.84986357
146MP0003633_abnormal_nervous_system0.84525327
147MP0000689_abnormal_spleen_morphology0.82991806
148MP0002429_abnormal_blood_cell0.82619393
149MP0001765_abnormal_ion_homeostasis0.82420673
150MP0003436_decreased_susceptibility_to0.80449942
151MP0003638_abnormal_response/metabolism_0.79865137
152MP0002693_abnormal_pancreas_physiology0.79714664
153MP0000537_abnormal_urethra_morphology0.78566928
154MP0009333_abnormal_splenocyte_physiolog0.78465241
155MP0005408_hypopigmentation0.78104686
156MP0000230_abnormal_systemic_arterial0.77907371
157MP0001485_abnormal_pinna_reflex0.77571571
158MP0006036_abnormal_mitochondrial_physio0.77210253
159MP0002419_abnormal_innate_immunity0.77164214
160MP0002733_abnormal_thermal_nociception0.77086385
161MP0002722_abnormal_immune_system0.76649241
162MP0000678_abnormal_parathyroid_gland0.76502123
163MP0005395_other_phenotype0.76406849
164MP0001661_extended_life_span0.76078554
165MP0004215_abnormal_myocardial_fiber0.75513233
166MP0000631_abnormal_neuroendocrine_gland0.75404789
167MP0002136_abnormal_kidney_physiology0.74548206
168MP0002876_abnormal_thyroid_physiology0.73968247
169MP0002161_abnormal_fertility/fecundity0.71346843
170MP0002272_abnormal_nervous_system0.70980042
171MP0000538_abnormal_urinary_bladder0.70620223
172MP0002064_seizures0.70227399
173MP0004510_myositis0.68868569
174MP0000015_abnormal_ear_pigmentation0.67618818
175MP0008775_abnormal_heart_ventricle0.64091648
176MP0002168_other_aberrant_phenotype0.63710518
177MP0000653_abnormal_sex_gland0.62515431
178MP0009642_abnormal_blood_homeostasis0.62388759
179MP0002090_abnormal_vision0.61813946

Predicted human phenotypes

RankGene SetZ-score
1Abnormal number of erythroid precursors (HP:0012131)5.24272043
2Abnormality of cells of the erythroid lineage (HP:0012130)5.05387763
3Interstitial pulmonary disease (HP:0006530)4.93177220
4Thrombocytosis (HP:0001894)4.14018293
5Dynein arm defect of respiratory motile cilia (HP:0012255)4.00886896
6Absent/shortened dynein arms (HP:0200106)4.00886896
7Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.98569090
8Hyperactive renin-angiotensin system (HP:0000841)3.95854991
9Abnormal ciliary motility (HP:0012262)3.95105552
10Abnormal respiratory epithelium morphology (HP:0012253)3.93602210
11Abnormal respiratory motile cilium morphology (HP:0005938)3.93602210
12Abnormal respiratory motile cilium physiology (HP:0012261)3.91743968
13Rhinitis (HP:0012384)3.63345068
14Severe visual impairment (HP:0001141)3.50776735
15Congenital malformation of the right heart (HP:0011723)3.50213185
16Double outlet right ventricle (HP:0001719)3.50213185
17Hypoglycemic seizures (HP:0002173)3.47027900
18Hypoglycemic coma (HP:0001325)3.39380299
19Onycholysis (HP:0001806)3.37652285
20Hyperglycemia (HP:0003074)3.33053449
21IgM deficiency (HP:0002850)3.30724709
22Vascular calcification (HP:0004934)3.30310563
23Gout (HP:0001997)3.30177083
24Aplastic anemia (HP:0001915)3.26715928
25Hyperinsulinemic hypoglycemia (HP:0000825)3.13400114
26Tubulointerstitial nephritis (HP:0001970)3.09157128
27Ketoacidosis (HP:0001993)3.08276423
28Tubulointerstitial fibrosis (HP:0005576)3.04593930
29Insulin-resistant diabetes mellitus (HP:0000831)3.02971176
30Reduced antithrombin III activity (HP:0001976)3.01832830
31Attenuation of retinal blood vessels (HP:0007843)2.98714826
32Abnormal rod and cone electroretinograms (HP:0008323)2.98151879
33Abnormality of chloride homeostasis (HP:0011422)2.97727423
34Chronic otitis media (HP:0000389)2.95662408
35Aplasia/Hypoplasia of the sacrum (HP:0008517)2.94329923
36Unilateral renal agenesis (HP:0000122)2.92750831
37Right ventricular cardiomyopathy (HP:0011663)2.92381517
38Micronodular cirrhosis (HP:0001413)2.91694370
39Reticulocytopenia (HP:0001896)2.89528145
40Intestinal atresia (HP:0011100)2.83504483
41Cardiovascular calcification (HP:0011915)2.81170108
42Type I transferrin isoform profile (HP:0003642)2.77732511
43Bony spicule pigmentary retinopathy (HP:0007737)2.73489460
44Hyperthyroidism (HP:0000836)2.71853780
45Chronic bronchitis (HP:0004469)2.64279079
46Nephronophthisis (HP:0000090)2.62969971
47Petechiae (HP:0000967)2.59101113
48Pancreatic fibrosis (HP:0100732)2.57314788
49Abnormal albumin level (HP:0012116)2.54616757
50Hypoalbuminemia (HP:0003073)2.54616757
51Abnormal protein glycosylation (HP:0012346)2.51782864
52Abnormal glycosylation (HP:0012345)2.51782864
53Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.51782864
54Abnormal protein N-linked glycosylation (HP:0012347)2.51782864
5511 pairs of ribs (HP:0000878)2.48609654
56Azoospermia (HP:0000027)2.48544139
57Nonprogressive disorder (HP:0003680)2.45508065
58Glycosuria (HP:0003076)2.45088446
59Abnormality of urine glucose concentration (HP:0011016)2.45088446
60Symptomatic seizures (HP:0011145)2.43412424
61Prolonged bleeding time (HP:0003010)2.43393165
62Hypomagnesemia (HP:0002917)2.42801624
63Increased CSF protein (HP:0002922)2.41922574
64Large for gestational age (HP:0001520)2.40727156
65Infertility (HP:0000789)2.40639655
66Late onset (HP:0003584)2.40320928
67Renal salt wasting (HP:0000127)2.40256796
68Abnormality of the renal cortex (HP:0011035)2.36251110
69Abnormal drinking behavior (HP:0030082)2.34572186
70Polydipsia (HP:0001959)2.34572186
71Abnormal pancreas size (HP:0012094)2.31237008
72Abnormality of the intrinsic pathway (HP:0010989)2.30059478
73Abnormality of the nasal mucosa (HP:0000433)2.29098998
74Medial flaring of the eyebrow (HP:0010747)2.28481375
75Abnormality of vitamin metabolism (HP:0100508)2.24810703
76Bronchiectasis (HP:0002110)2.23105334
77Palpitations (HP:0001962)2.22197185
78Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.21972613
79Bronchitis (HP:0012387)2.21200607
80True hermaphroditism (HP:0010459)2.20594922
81Ketosis (HP:0001946)2.20592563
82Abnormality of the renal medulla (HP:0100957)2.20489099
83Progressive neurologic deterioration (HP:0002344)2.19542714
84Autoimmune thrombocytopenia (HP:0001973)2.19298207
85Hyperphosphatemia (HP:0002905)2.17941391
86Sex reversal (HP:0012245)2.17721300
87Abnormal sex determination (HP:0012244)2.17721300
88Fatigue (HP:0012378)2.17142903
89Pustule (HP:0200039)2.16962029
90Enlarged penis (HP:0000040)2.16829472
91Hyperkalemia (HP:0002153)2.16630572
92Gastrointestinal stroma tumor (HP:0100723)2.15637373
93Macrocytic anemia (HP:0001972)2.15075260
94Testicular neoplasm (HP:0010788)2.14623544
95Abnormality of renal excretion (HP:0011036)2.13820752
96Type 2 muscle fiber atrophy (HP:0003554)2.13547371
97Respiratory distress (HP:0002098)2.13339124
98Abnormality of T cell physiology (HP:0011840)2.13047362
99Nuclear cataract (HP:0100018)2.12318197
100Tubular atrophy (HP:0000092)2.12270628
101Abnormal tarsal ossification (HP:0008369)2.10407175
102Recurrent abscess formation (HP:0002722)2.09273283
103Hypothermia (HP:0002045)2.09078984
104Abnormality of macular pigmentation (HP:0008002)2.08826237
105Molar tooth sign on MRI (HP:0002419)2.07987092
106Abnormality of midbrain morphology (HP:0002418)2.07987092
107Abnormality of aromatic amino acid family metabolism (HP:0004338)2.06870605
108Chronic hepatic failure (HP:0100626)2.04895260
109Hemiparesis (HP:0001269)2.04352681
110Nasal polyposis (HP:0100582)2.04029454
111Pancreatic cysts (HP:0001737)2.02665922
112Tubulointerstitial abnormality (HP:0001969)2.02605742
113Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.01357925
114Decreased activity of mitochondrial respiratory chain (HP:0008972)2.01357925
115Abnormality of vitamin B metabolism (HP:0004340)2.00445421
116Recurrent bacterial skin infections (HP:0005406)2.00241540
117Myositis (HP:0100614)2.00166444
118Pili torti (HP:0003777)2.00090342
119Abnormality of renal resorption (HP:0011038)1.99524428
120Male infertility (HP:0003251)1.97127779
121Ileus (HP:0002595)1.97099082
122Generalized aminoaciduria (HP:0002909)1.96881178
123Vacuolated lymphocytes (HP:0001922)1.96448426
124Microretrognathia (HP:0000308)1.95442320
125Beaking of vertebral bodies (HP:0004568)1.95388222
126Periodontitis (HP:0000704)1.94873139
127Exocrine pancreatic insufficiency (HP:0001738)1.94453756
128Recurrent bronchitis (HP:0002837)1.92481626
129Elevated erythrocyte sedimentation rate (HP:0003565)1.91515310
130Tachypnea (HP:0002789)1.90792102
131Furrowed tongue (HP:0000221)1.90653983
132Stage 5 chronic kidney disease (HP:0003774)1.89220482
133Abnormality of magnesium homeostasis (HP:0004921)1.87545645
134Recurrent sinusitis (HP:0011108)1.87480277
135Pallor (HP:0000980)1.87195125
136Abnormality of the vitamin B12 metabolism (HP:0004341)1.86063810
137Abnormality of endocrine pancreas physiology (HP:0012093)1.85702922
138Abnormality of the pancreatic islet cells (HP:0006476)1.85702922
139Abnormality of renin-angiotensin system (HP:0000847)1.84959038
140Abdominal distention (HP:0003270)1.84866780
141Abnormality of the heme biosynthetic pathway (HP:0010472)1.84638458
142Hypoproteinemia (HP:0003075)1.83935453
143EEG with generalized epileptiform discharges (HP:0011198)1.83810828
144Menstrual irregularities (HP:0000858)1.82831556
145Congenital sensorineural hearing impairment (HP:0008527)1.82775022
146Renal cortical cysts (HP:0000803)1.82547322
147Ventricular fibrillation (HP:0001663)1.81869091
148Protuberant abdomen (HP:0001538)1.81088996
149Milia (HP:0001056)1.80623262
150Polyuria (HP:0000103)1.80061871
151Partial duplication of thumb phalanx (HP:0009944)1.79428155
152Hyperaldosteronism (HP:0000859)1.79348822
153Retinal atrophy (HP:0001105)1.79253478
154Chronic diarrhea (HP:0002028)1.79201109
155Abnormal spermatogenesis (HP:0008669)1.78219355
156Congenital primary aphakia (HP:0007707)1.78144712
157Abnormality of macrophages (HP:0004311)1.77813950
158Epileptiform EEG discharges (HP:0011182)1.77301609
159Abnormal urine output (HP:0012590)1.77065811
160Occipital encephalocele (HP:0002085)1.77036294
161Weak cry (HP:0001612)1.76501322
162Glucose intolerance (HP:0000833)1.75762531
163Muscle fiber atrophy (HP:0100295)1.74899765
164Impaired platelet aggregation (HP:0003540)1.74768897
165Abnormal platelet function (HP:0011869)1.74768897
166Flat acetabular roof (HP:0003180)1.74528064
167Dehydration (HP:0001944)1.74156059
168Flattened epiphyses (HP:0003071)1.74153003
169Poikiloderma (HP:0001029)1.74131556
170Abnormal foot bone ossification (HP:0010675)1.73920714
171Cystic liver disease (HP:0006706)1.73420442
172Increased circulating renin level (HP:0000848)1.73357101
173Lymphopenia (HP:0001888)1.73321822
174Epistaxis (HP:0000421)1.73252001
175Abnormality of calcium-phosphate metabolism (HP:0100530)1.73077839
176Congenital, generalized hypertrichosis (HP:0004540)1.72691683
177Optic nerve coloboma (HP:0000588)1.72277064
178Decreased circulating renin level (HP:0003351)1.71446633
179Resting tremor (HP:0002322)1.70657967
180Thin bony cortex (HP:0002753)1.69956066
181Fat malabsorption (HP:0002630)1.69184803
182Increased IgE level (HP:0003212)1.68599152
183Thyroid-stimulating hormone excess (HP:0002925)1.67466384
184Woolly hair (HP:0002224)1.66118645
185Subacute progressive viral hepatitis (HP:0006572)1.65683358

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NEK14.06228135
2MAP4K23.54040650
3NME23.38136205
4FGFR22.97049583
5FLT32.62359623
6PRKG22.49759607
7STK38L2.16324929
8MAP3K122.09364050
9LMTK22.09110591
10TEC2.08288318
11PKN22.04133041
12MST42.02268829
13PHKG11.97262406
14PHKG21.97262406
15ZAP701.93950301
16FRK1.92532606
17MAP4K11.89186349
18EIF2AK31.86111889
19BTK1.85161218
20MUSK1.82781054
21NEK21.82111246
22MYLK1.70919157
23KIT1.69580566
24CASK1.67594867
25PNCK1.65415991
26STK381.64441509
27TGFBR21.64176423
28STK241.63909179
29NTRK31.63752358
30TIE11.63437151
31MST1R1.60688759
32PIK3CG1.59079525
33FGFR31.58441919
34MAP3K21.53353015
35PTK2B1.51879720
36PINK11.51464045
37MAP2K61.48221767
38PLK21.41368272
39RPS6KB21.36372460
40MAP2K21.36342681
41ACVR1B1.36282276
42ERBB31.36110852
43DAPK21.35844136
44TAOK31.33223565
45BMPR1B1.30385127
46STK31.30352680
47IRAK41.28774822
48CDK191.26630890
49PRKCE1.26137241
50WNK31.25795109
51TGFBR11.25728124
52MAP3K41.25044487
53JAK31.24846890
54INSRR1.24793503
55PIM21.24656298
56LRRK21.23673807
57FER1.23640627
58MAP3K31.23060245
59MAP3K111.23008350
60OXSR11.21682248
61BCKDK1.20663492
62IKBKE1.20374607
63TBK11.17876881
64MATK1.17585600
65PLK41.17420808
66ERN11.17334401
67TESK11.10438876
68NUAK11.09736961
69MAPK151.09624860
70CSF1R1.08815369
71STK391.06197113
72IRAK31.04897811
73AKT31.00076701
74PAK40.99996894
75PASK0.97947741
76MAP3K90.95428666
77MKNK10.94121601
78PIK3CA0.93707313
79DYRK1B0.92550643
80EIF2AK10.91014794
81AURKB0.84565708
82PAK30.84377889
83CAMK2D0.83794753
84PTK60.83454908
85CAMK1G0.81562639
86RIPK40.80973277
87GRK10.79830836
88STK160.78558862
89BRSK20.77935788
90CHUK0.77363934
91PDK10.76598994
92TNK20.76485822
93ILK0.74028531
94NME10.73975965
95MAP2K30.72936490
96PRKCG0.71674643
97TNIK0.71142329
98SYK0.70901019
99MAPKAPK50.70890118
100PIM10.69974998
101TYK20.69878908
102PDPK10.68610056
103MKNK20.68476821
104TAOK10.68238847
105IRAK20.66370848
106ROCK10.65625644
107DDR20.64998833
108CSNK1G10.64763184
109PRKG10.64401128
110TXK0.63066162
111STK100.62779669
112HIPK20.61380007
113PRKAA10.56632889
114EPHA30.54471806
115ADRBK20.53727924
116IKBKB0.53662829
117PRKCQ0.53570994
118YES10.51704748
119PRKCI0.51687528
120TRPM70.51190260
121LYN0.49094501
122WNK40.47875651
123ITK0.47659153
124RPS6KA40.47534958
125CAMKK20.47273365
126CCNB10.47233357
127STK110.47037123
128DYRK30.46822711
129WNK10.46423423
130PDGFRB0.46361888
131CSNK1G30.46141777
132IRAK10.45837663
133TRIB30.45251677
134EPHB20.45250439
135PRKCD0.43078713
136CDK60.42730415
137UHMK10.42033224
138ERBB40.40750222
139CSNK1G20.39857758
140CAMK2A0.39314263
141MAPKAPK30.38965240
142ZAK0.38745998
143PRKCA0.38540166
144EPHA20.38353534
145EIF2AK20.37360510
146PRKCZ0.37221609
147NLK0.37179707
148TLK10.37091309
149WEE10.36138326
150PRKACA0.35936034
151ADRBK10.33872152
152PRKAA20.33648227
153RIPK10.33521429
154MET0.33397245
155RPS6KA60.32757625
156RPS6KC10.32589123
157MAP3K10.30766226
158CSNK1A10.28276791
159SGK20.28171117
160MAP3K70.27298867
161CAMK10.25855002
162PRKACB0.25574533
163CSNK1D0.24698670
164PRKCB0.24272064
165BRD40.23405706
166MAP2K70.22898246

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.33425284
2Caffeine metabolism_Homo sapiens_hsa002323.77258984
3Ribosome_Homo sapiens_hsa030103.75808077
4Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006013.05353173
5Butanoate metabolism_Homo sapiens_hsa006502.83929100
6Sulfur metabolism_Homo sapiens_hsa009202.69114912
7Protein export_Homo sapiens_hsa030602.63483302
8Folate biosynthesis_Homo sapiens_hsa007902.63232072
9Maturity onset diabetes of the young_Homo sapiens_hsa049502.47639734
10Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.28247688
11Vitamin B6 metabolism_Homo sapiens_hsa007502.17537746
12Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.15018047
13Insulin secretion_Homo sapiens_hsa049112.11428306
14Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.02118125
15Glutathione metabolism_Homo sapiens_hsa004802.01143497
16Collecting duct acid secretion_Homo sapiens_hsa049661.99739299
17DNA replication_Homo sapiens_hsa030301.99590907
18Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.84334439
19Fat digestion and absorption_Homo sapiens_hsa049751.76617217
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.74191781
21Mineral absorption_Homo sapiens_hsa049781.70349723
22Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.67907462
23N-Glycan biosynthesis_Homo sapiens_hsa005101.62336127
24Pancreatic secretion_Homo sapiens_hsa049721.56362268
25Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.55775080
26Pyrimidine metabolism_Homo sapiens_hsa002401.55503397
27Nitrogen metabolism_Homo sapiens_hsa009101.55039206
28Chemical carcinogenesis_Homo sapiens_hsa052041.54644005
29Type I diabetes mellitus_Homo sapiens_hsa049401.52842469
30Histidine metabolism_Homo sapiens_hsa003401.51424834
31Phototransduction_Homo sapiens_hsa047441.51065433
32SNARE interactions in vesicular transport_Homo sapiens_hsa041301.50811299
33Vitamin digestion and absorption_Homo sapiens_hsa049771.50115513
34Circadian rhythm_Homo sapiens_hsa047101.46256723
35Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.45539539
36Arachidonic acid metabolism_Homo sapiens_hsa005901.44046434
37Intestinal immune network for IgA production_Homo sapiens_hsa046721.43210114
38Protein digestion and absorption_Homo sapiens_hsa049741.37529734
39Other glycan degradation_Homo sapiens_hsa005111.31046930
40Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.30870813
41Fatty acid elongation_Homo sapiens_hsa000621.25882506
42Pentose and glucuronate interconversions_Homo sapiens_hsa000401.23485084
43Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.21250592
44Retinol metabolism_Homo sapiens_hsa008301.20036835
45alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.19623060
46Leukocyte transendothelial migration_Homo sapiens_hsa046701.19557579
47Primary immunodeficiency_Homo sapiens_hsa053401.18327259
48Fatty acid metabolism_Homo sapiens_hsa012121.18111014
49Homologous recombination_Homo sapiens_hsa034401.16893344
50Mismatch repair_Homo sapiens_hsa034301.15271068
51Primary bile acid biosynthesis_Homo sapiens_hsa001201.13513175
52Cyanoamino acid metabolism_Homo sapiens_hsa004601.07453978
53Propanoate metabolism_Homo sapiens_hsa006401.06731075
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.05828306
55Type II diabetes mellitus_Homo sapiens_hsa049301.05573352
56Synaptic vesicle cycle_Homo sapiens_hsa047211.04044251
57Linoleic acid metabolism_Homo sapiens_hsa005911.03695429
58beta-Alanine metabolism_Homo sapiens_hsa004101.00274696
59Fructose and mannose metabolism_Homo sapiens_hsa000511.00202725
60Pentose phosphate pathway_Homo sapiens_hsa000300.99896926
61Renin secretion_Homo sapiens_hsa049240.97717714
62Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.97072312
63Arginine biosynthesis_Homo sapiens_hsa002200.96718051
64Hepatitis C_Homo sapiens_hsa051600.96126125
65Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.96015619
66Purine metabolism_Homo sapiens_hsa002300.95515155
67Glycosaminoglycan degradation_Homo sapiens_hsa005310.93330658
68Vibrio cholerae infection_Homo sapiens_hsa051100.92934877
69Fatty acid biosynthesis_Homo sapiens_hsa000610.92899123
70Sulfur relay system_Homo sapiens_hsa041220.92505116
71Olfactory transduction_Homo sapiens_hsa047400.91747577
72Salivary secretion_Homo sapiens_hsa049700.89199316
73Thyroid cancer_Homo sapiens_hsa052160.89107810
74ABC transporters_Homo sapiens_hsa020100.89008024
75Glycerophospholipid metabolism_Homo sapiens_hsa005640.88484244
76RNA polymerase_Homo sapiens_hsa030200.87854872
77Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.86740913
78Legionellosis_Homo sapiens_hsa051340.83482434
79Sphingolipid metabolism_Homo sapiens_hsa006000.83408909
80Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.83107232
81Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.82878476
82RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.81968604
83Transcriptional misregulation in cancer_Homo sapiens_hsa052020.81063856
84Serotonergic synapse_Homo sapiens_hsa047260.80410910
85Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.80061281
86Tyrosine metabolism_Homo sapiens_hsa003500.75477868
87Base excision repair_Homo sapiens_hsa034100.75352445
88Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.74733576
89Galactose metabolism_Homo sapiens_hsa000520.74593434
90Carbohydrate digestion and absorption_Homo sapiens_hsa049730.74458829
91Steroid hormone biosynthesis_Homo sapiens_hsa001400.74210918
92Regulation of autophagy_Homo sapiens_hsa041400.73768579
93Pertussis_Homo sapiens_hsa051330.72856922
94Leishmaniasis_Homo sapiens_hsa051400.72614435
95NF-kappa B signaling pathway_Homo sapiens_hsa040640.71606681
96Phenylalanine metabolism_Homo sapiens_hsa003600.71367523
97Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.71270049
98Fatty acid degradation_Homo sapiens_hsa000710.70831822
99Platelet activation_Homo sapiens_hsa046110.70488607
100Renin-angiotensin system_Homo sapiens_hsa046140.70407880
101Taste transduction_Homo sapiens_hsa047420.70124580
102Influenza A_Homo sapiens_hsa051640.69845506
103Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.69626644
104Hematopoietic cell lineage_Homo sapiens_hsa046400.69189188
105Drug metabolism - other enzymes_Homo sapiens_hsa009830.69047568
106Proteasome_Homo sapiens_hsa030500.68620164
107Glucagon signaling pathway_Homo sapiens_hsa049220.68444254
108Inositol phosphate metabolism_Homo sapiens_hsa005620.68090109
109Dorso-ventral axis formation_Homo sapiens_hsa043200.67644581
110Jak-STAT signaling pathway_Homo sapiens_hsa046300.67462739
111Circadian entrainment_Homo sapiens_hsa047130.66451802
112Bile secretion_Homo sapiens_hsa049760.65257937
113Antigen processing and presentation_Homo sapiens_hsa046120.65195517
114Peroxisome_Homo sapiens_hsa041460.61979596
115Herpes simplex infection_Homo sapiens_hsa051680.60787905
116Amphetamine addiction_Homo sapiens_hsa050310.59747917
117RNA degradation_Homo sapiens_hsa030180.59550948
118Glycerolipid metabolism_Homo sapiens_hsa005610.59443176
119Arginine and proline metabolism_Homo sapiens_hsa003300.57825220
120Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.56798653
121Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.56246714
122Selenocompound metabolism_Homo sapiens_hsa004500.55386705
123Metabolic pathways_Homo sapiens_hsa011000.54943950
124Parkinsons disease_Homo sapiens_hsa050120.54815958
125Non-homologous end-joining_Homo sapiens_hsa034500.53853019
126Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53249218
127Ether lipid metabolism_Homo sapiens_hsa005650.52830773
128Cardiac muscle contraction_Homo sapiens_hsa042600.51697059
129B cell receptor signaling pathway_Homo sapiens_hsa046620.49987436
130Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.49741520
131Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47344139
132Malaria_Homo sapiens_hsa051440.47041992
133Asthma_Homo sapiens_hsa053100.46828732
134Phosphatidylinositol signaling system_Homo sapiens_hsa040700.45754957
135Starch and sucrose metabolism_Homo sapiens_hsa005000.45495156
136cAMP signaling pathway_Homo sapiens_hsa040240.44570432
137Tight junction_Homo sapiens_hsa045300.44282642
138Lysosome_Homo sapiens_hsa041420.44250746
139PPAR signaling pathway_Homo sapiens_hsa033200.43716647
140Oxidative phosphorylation_Homo sapiens_hsa001900.43464608
141Gastric acid secretion_Homo sapiens_hsa049710.42587903
142Complement and coagulation cascades_Homo sapiens_hsa046100.42471481
143Apoptosis_Homo sapiens_hsa042100.42423051
144Spliceosome_Homo sapiens_hsa030400.41308745
145Toxoplasmosis_Homo sapiens_hsa051450.41244038
146Insulin resistance_Homo sapiens_hsa049310.40738498
147Measles_Homo sapiens_hsa051620.40351020
148Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.39764958
149NOD-like receptor signaling pathway_Homo sapiens_hsa046210.39543202
150GABAergic synapse_Homo sapiens_hsa047270.39011907
151Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.39005885
152Tryptophan metabolism_Homo sapiens_hsa003800.38716845
153Huntingtons disease_Homo sapiens_hsa050160.38337302
154Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.37773662
155Thyroid hormone synthesis_Homo sapiens_hsa049180.33299306
156Acute myeloid leukemia_Homo sapiens_hsa052210.33096022
157Shigellosis_Homo sapiens_hsa051310.32433400
158Salmonella infection_Homo sapiens_hsa051320.32348577

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