SMIM7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1signal peptide processing (GO:0006465)5.32776845
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.04438176
3chaperone-mediated protein transport (GO:0072321)4.85262585
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.83058684
5ATP synthesis coupled proton transport (GO:0015986)4.80277229
6energy coupled proton transport, down electrochemical gradient (GO:0015985)4.80277229
7protein neddylation (GO:0045116)4.56845892
8establishment of protein localization to mitochondrial membrane (GO:0090151)4.48182401
9cullin deneddylation (GO:0010388)4.30867795
10protein complex biogenesis (GO:0070271)4.28672555
11respiratory electron transport chain (GO:0022904)4.13303423
12presynaptic membrane assembly (GO:0097105)4.08841521
13protein deneddylation (GO:0000338)4.05266314
14electron transport chain (GO:0022900)4.02819152
15presynaptic membrane organization (GO:0097090)3.99810825
16water-soluble vitamin biosynthetic process (GO:0042364)3.93645597
17fatty acid elongation (GO:0030497)3.84001205
18mitochondrial respiratory chain complex I assembly (GO:0032981)3.82802777
19NADH dehydrogenase complex assembly (GO:0010257)3.82802777
20mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.82802777
21mannosylation (GO:0097502)3.82216062
22nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.78544203
23mitochondrial respiratory chain complex assembly (GO:0033108)3.77060577
24viral protein processing (GO:0019082)3.71861106
25nucleotide transmembrane transport (GO:1901679)3.69779730
26response to redox state (GO:0051775)3.68541480
27exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.68382761
28platelet dense granule organization (GO:0060155)3.63151432
29axon ensheathment in central nervous system (GO:0032291)3.57695780
30central nervous system myelination (GO:0022010)3.57695780
31ER overload response (GO:0006983)3.56788080
32peptidyl-histidine modification (GO:0018202)3.53473963
33L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.48572114
34regulation of cilium movement (GO:0003352)3.44327497
35DNA deamination (GO:0045006)3.35183385
36protein maturation by protein folding (GO:0022417)3.35062479
37behavioral response to nicotine (GO:0035095)3.32745674
38cholesterol biosynthetic process (GO:0006695)3.31850688
39COPI coating of Golgi vesicle (GO:0048205)3.30148049
40Golgi transport vesicle coating (GO:0048200)3.30148049
41GMP metabolic process (GO:0046037)3.16695286
42preassembly of GPI anchor in ER membrane (GO:0016254)3.09561713
43intracellular protein transmembrane import (GO:0044743)3.01428606
44pseudouridine synthesis (GO:0001522)3.01407732
45respiratory chain complex IV assembly (GO:0008535)3.00157312
46rRNA modification (GO:0000154)2.99931169
47isoprenoid biosynthetic process (GO:0008299)2.99492388
48long-chain fatty acid biosynthetic process (GO:0042759)2.99175007
49DNA double-strand break processing (GO:0000729)2.97523208
50GDP-mannose metabolic process (GO:0019673)2.95624896
51cellular ketone body metabolic process (GO:0046950)2.90480417
52C-terminal protein lipidation (GO:0006501)2.90136570
53hydrogen transport (GO:0006818)2.89320170
54sterol biosynthetic process (GO:0016126)2.87240007
55dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.86399549
56GTP biosynthetic process (GO:0006183)2.84481401
57termination of RNA polymerase III transcription (GO:0006386)2.83260342
58transcription elongation from RNA polymerase III promoter (GO:0006385)2.83260342
59regulation of cellular amino acid metabolic process (GO:0006521)2.82637457
60replication fork processing (GO:0031297)2.82444733
61purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.82150486
62ATP biosynthetic process (GO:0006754)2.81414407
63virion assembly (GO:0019068)2.80546795
64protein targeting to mitochondrion (GO:0006626)2.79982096
65C-terminal protein amino acid modification (GO:0018410)2.78812732
66guanosine-containing compound biosynthetic process (GO:1901070)2.76406742
67indolalkylamine metabolic process (GO:0006586)2.76265962
687-methylguanosine mRNA capping (GO:0006370)2.76136096
69epithelial cilium movement (GO:0003351)2.75184407
70L-methionine salvage (GO:0071267)2.74842155
71L-methionine biosynthetic process (GO:0071265)2.74842155
72amino acid salvage (GO:0043102)2.74842155
73tRNA processing (GO:0008033)2.73212638
74protein K6-linked ubiquitination (GO:0085020)2.72990411
75deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.72957622
76ubiquinone metabolic process (GO:0006743)2.72315051
77establishment of protein localization to mitochondrion (GO:0072655)2.72259476
78nonmotile primary cilium assembly (GO:0035058)2.71661014
79prenylation (GO:0097354)2.71261116
80protein prenylation (GO:0018342)2.71261116
81positive regulation of mitochondrial fission (GO:0090141)2.70960841
82protein localization to mitochondrion (GO:0070585)2.70253983
83cytochrome complex assembly (GO:0017004)2.68470266
84tryptophan catabolic process (GO:0006569)2.67534281
85indole-containing compound catabolic process (GO:0042436)2.67534281
86indolalkylamine catabolic process (GO:0046218)2.67534281
87rRNA methylation (GO:0031167)2.66192623
88GPI anchor biosynthetic process (GO:0006506)2.65356943
89deoxyribose phosphate biosynthetic process (GO:0046385)2.65226631
902-deoxyribonucleotide biosynthetic process (GO:0009265)2.65226631
91regulation of rhodopsin mediated signaling pathway (GO:0022400)2.64702029
92RNA capping (GO:0036260)2.64338388
937-methylguanosine RNA capping (GO:0009452)2.64338388
94regulation of glucokinase activity (GO:0033131)2.63432374
95regulation of hexokinase activity (GO:1903299)2.63432374
96limb bud formation (GO:0060174)2.63246425
97ketone body metabolic process (GO:1902224)2.62668413
98signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.62037250
99signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.62037250
100signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.62037250
101detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.62002142
102regulation of mitochondrial translation (GO:0070129)2.61697364
103anterograde synaptic vesicle transport (GO:0048490)2.61480363
104substantia nigra development (GO:0021762)2.60651026
105regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.60545427
106negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.59689828
107positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.58266739
108branched-chain amino acid catabolic process (GO:0009083)2.57739187
109hydrogen ion transmembrane transport (GO:1902600)2.57073932
110intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.56795536
111signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.56795536
112glandular epithelial cell differentiation (GO:0002067)2.56130149
113maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.56093811
114adenosine metabolic process (GO:0046085)2.52389574
115negative regulation of telomere maintenance (GO:0032205)2.51939884
116photoreceptor cell differentiation (GO:0046530)2.49685712
117eye photoreceptor cell differentiation (GO:0001754)2.49685712
118epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.49554591
119rhodopsin mediated signaling pathway (GO:0016056)2.48945616
120inner mitochondrial membrane organization (GO:0007007)2.48860364
121antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.48839350
122maturation of 5.8S rRNA (GO:0000460)2.48670858
123protein-cofactor linkage (GO:0018065)2.48201422
124positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.48163934
125proteasome assembly (GO:0043248)2.47873592
126magnesium ion transport (GO:0015693)2.47671839
127aldehyde catabolic process (GO:0046185)2.47484260
128ATP hydrolysis coupled proton transport (GO:0015991)2.47109730
129energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.47109730
130GPI anchor metabolic process (GO:0006505)2.45902519
131intraciliary transport (GO:0042073)2.45054437
132protein retention in ER lumen (GO:0006621)2.44962782
133negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.44703971
134mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.41814046
135positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.41814046
136negative regulation of neurotransmitter secretion (GO:0046929)2.40671206
137proton transport (GO:0015992)2.39544619
138regulation of oxidative phosphorylation (GO:0002082)2.38978529
139DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.38596891
140quinone metabolic process (GO:1901661)2.37702021
141tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.36518330
142RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.36518330
143oxidative phosphorylation (GO:0006119)2.36304594
144nucleotide transport (GO:0006862)2.36088030
145regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.35867972
146neuron cell-cell adhesion (GO:0007158)2.34902022
147regulation of cellular amine metabolic process (GO:0033238)2.34240153
148purine nucleoside triphosphate biosynthetic process (GO:0009145)2.34037473
149regulation of collateral sprouting (GO:0048670)2.33967827
150quinone biosynthetic process (GO:1901663)2.32857997
151ubiquinone biosynthetic process (GO:0006744)2.32857997
152negative regulation of ligase activity (GO:0051352)2.32573498
153negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.32573498

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.12252598
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.36230232
3ZNF274_21170338_ChIP-Seq_K562_Hela3.05800839
4PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.82973288
5GBX2_23144817_ChIP-Seq_PC3_Human2.63622497
6EST1_17652178_ChIP-ChIP_JURKAT_Human2.55654084
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.52714840
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.48664292
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.43517562
10RBPJ_22232070_ChIP-Seq_NCS_Mouse2.40759220
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.33907671
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.22377351
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.21750713
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.08134158
15VDR_22108803_ChIP-Seq_LS180_Human2.05346569
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.00446161
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.97712943
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.95288896
19POU3F2_20337985_ChIP-ChIP_501MEL_Human1.92491072
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.91685014
21BMI1_23680149_ChIP-Seq_NPCS_Mouse1.89656506
22ELF1_17652178_ChIP-ChIP_JURKAT_Human1.78737204
23MYC_18940864_ChIP-ChIP_HL60_Human1.78404241
24FOXP3_21729870_ChIP-Seq_TREG_Human1.74111932
25SRF_21415370_ChIP-Seq_HL-1_Mouse1.73696841
26EED_16625203_ChIP-ChIP_MESCs_Mouse1.73482416
27TAF15_26573619_Chip-Seq_HEK293_Human1.73436682
28HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.66079018
29WT1_19549856_ChIP-ChIP_CCG9911_Human1.65443483
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.63876932
31SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.63813813
32FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.62494621
33ETS1_20019798_ChIP-Seq_JURKAT_Human1.61543110
34SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.59678308
35SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.58827048
36EZH2_27304074_Chip-Seq_ESCs_Mouse1.58668888
37E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.56498309
38SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.52467078
39EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.50798595
40PCGF2_27294783_Chip-Seq_ESCs_Mouse1.49051737
41OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48967712
42FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.48137878
43PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.46281171
44THAP11_20581084_ChIP-Seq_MESCs_Mouse1.46271657
45ELK1_19687146_ChIP-ChIP_HELA_Human1.46057074
46PADI4_21655091_ChIP-ChIP_MCF-7_Human1.45846170
47IRF1_19129219_ChIP-ChIP_H3396_Human1.45744479
48FUS_26573619_Chip-Seq_HEK293_Human1.44570130
49P300_19829295_ChIP-Seq_ESCs_Human1.44004277
50SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.41575035
51SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.38012410
52GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.37840690
53NOTCH1_21737748_ChIP-Seq_TLL_Human1.37717780
54ELK1_22589737_ChIP-Seq_MCF10A_Human1.36309338
55SALL1_21062744_ChIP-ChIP_HESCs_Human1.35994823
56CTBP1_25329375_ChIP-Seq_LNCAP_Human1.35441309
57GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34749886
58CTBP2_25329375_ChIP-Seq_LNCAP_Human1.31944077
59CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.30762897
60TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28261305
61FOXA1_25329375_ChIP-Seq_VCAP_Human1.26389985
62FOXA1_27270436_Chip-Seq_PROSTATE_Human1.26389985
63JARID2_20075857_ChIP-Seq_MESCs_Mouse1.25793755
64PIAS1_25552417_ChIP-Seq_VCAP_Human1.25683078
65CBX2_27304074_Chip-Seq_ESCs_Mouse1.23549671
66RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.23321705
67AR_20517297_ChIP-Seq_VCAP_Human1.22553288
68JARID2_20064375_ChIP-Seq_MESCs_Mouse1.19536993
69UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19302389
70NFE2_27457419_Chip-Seq_LIVER_Mouse1.18755719
71SUZ12_27294783_Chip-Seq_NPCs_Mouse1.18671074
72REST_19997604_ChIP-ChIP_NEURONS_Mouse1.18197319
73CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.17882607
74ER_23166858_ChIP-Seq_MCF-7_Human1.17719918
75* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.16842603
76EZH2_27294783_Chip-Seq_NPCs_Mouse1.16403865
77MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.15388641
78E2F4_17652178_ChIP-ChIP_JURKAT_Human1.14236946
79AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13947228
80GABP_19822575_ChIP-Seq_HepG2_Human1.12991998
81EZH2_27294783_Chip-Seq_ESCs_Mouse1.12765640
82SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.11699165
83NRF2_20460467_ChIP-Seq_MEFs_Mouse1.11625203
84NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.11625203
85EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10881798
86CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.10330526
87DCP1A_22483619_ChIP-Seq_HELA_Human1.09261938
88SMAD3_21741376_ChIP-Seq_EPCs_Human1.09148005
89IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.08970793
90CBP_20019798_ChIP-Seq_JUKART_Human1.08970793
91CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.08960404
92EZH2_22144423_ChIP-Seq_EOC_Human1.08254258
93BCAT_22108803_ChIP-Seq_LS180_Human1.08142373
94SUZ12_27294783_Chip-Seq_ESCs_Mouse1.08119308
95GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06662877
96PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.04828148
97TTF2_22483619_ChIP-Seq_HELA_Human1.04636980
98P53_22387025_ChIP-Seq_ESCs_Mouse1.04127028
99NANOG_18555785_Chip-Seq_ESCs_Mouse1.03849874
100HOXB4_20404135_ChIP-ChIP_EML_Mouse1.02756213
101PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02290219
102AR_25329375_ChIP-Seq_VCAP_Human1.01876144
103FOXA1_21572438_ChIP-Seq_LNCaP_Human1.01443704
104MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00892678
105HTT_18923047_ChIP-ChIP_STHdh_Human1.00694339
106SOX17_20123909_ChIP-Seq_XEN_Mouse1.00524272
107VDR_23849224_ChIP-Seq_CD4+_Human1.00419637
108STAT3_18555785_Chip-Seq_ESCs_Mouse0.99674466
109PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.99664701
110NANOG_19829295_ChIP-Seq_ESCs_Human0.99385207
111SOX2_19829295_ChIP-Seq_ESCs_Human0.99385207
112POU5F1_16153702_ChIP-ChIP_HESCs_Human0.99169800
113AR_21572438_ChIP-Seq_LNCaP_Human0.98721371
114KLF5_20875108_ChIP-Seq_MESCs_Mouse0.98640959
115TCF4_22108803_ChIP-Seq_LS180_Human0.98617136
116EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.98150125
117SOX2_20726797_ChIP-Seq_SW620_Human0.98119487
118YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.97670805
119MTF2_20144788_ChIP-Seq_MESCs_Mouse0.97569396
120TAL1_26923725_Chip-Seq_HPCs_Mouse0.97557477
121CRX_20693478_ChIP-Seq_RETINA_Mouse0.97549461
122RNF2_18974828_ChIP-Seq_MESCs_Mouse0.97457988
123EZH2_18974828_ChIP-Seq_MESCs_Mouse0.97457988
124YY1_21170310_ChIP-Seq_MESCs_Mouse0.96998675
125RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.96619328
126SUZ12_18555785_Chip-Seq_ESCs_Mouse0.96273434
127NCOR_22424771_ChIP-Seq_293T_Human0.95717124
128TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.95470287
129SMAD4_21799915_ChIP-Seq_A2780_Human0.94953018
130GATA3_21878914_ChIP-Seq_MCF-7_Human0.94942591
131ETV2_25802403_ChIP-Seq_MESCs_Mouse0.94613306
132NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93643901
133HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.93201125
134EGR1_23403033_ChIP-Seq_LIVER_Mouse0.92149798
135TRIM28_21343339_ChIP-Seq_HEK293_Human0.91610952
136IGF1R_20145208_ChIP-Seq_DFB_Human0.91280856
137ERG_20517297_ChIP-Seq_VCAP_Human0.91057184
138ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.90557528
139NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.90504158
140E2F1_18555785_ChIP-Seq_MESCs_Mouse0.89687730
141EWS_26573619_Chip-Seq_HEK293_Human0.87695303
142PRDM14_20953172_ChIP-Seq_ESCs_Human0.87317000
143TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.87019037
144TP53_22573176_ChIP-Seq_HFKS_Human0.86648173

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010386_abnormal_urinary_bladder3.45357098
2MP0001529_abnormal_vocalization2.75161357
3MP0001986_abnormal_taste_sensitivity2.69520004
4MP0002102_abnormal_ear_morphology2.60594312
5MP0003195_calcinosis2.43761316
6MP0002837_dystrophic_cardiac_calcinosis2.42953268
7MP0004270_analgesia2.39662086
8MP0009379_abnormal_foot_pigmentation2.38755856
9MP0005171_absent_coat_pigmentation2.38111503
10MP0004043_abnormal_pH_regulation2.36941401
11MP0002638_abnormal_pupillary_reflex2.34342601
12MP0001984_abnormal_olfaction2.31603251
13MP0003011_delayed_dark_adaptation2.29896725
14MP0008875_abnormal_xenobiotic_pharmacok2.28454903
15MP0008058_abnormal_DNA_repair2.26386635
16MP0002736_abnormal_nociception_after2.22534342
17MP0003880_abnormal_central_pattern2.18152440
18MP0005646_abnormal_pituitary_gland2.03862361
19MP0008877_abnormal_DNA_methylation2.01228937
20MP0002734_abnormal_mechanical_nocicepti2.00779014
21MP0002876_abnormal_thyroid_physiology2.00563729
22MP0000013_abnormal_adipose_tissue2.00526478
23MP0001905_abnormal_dopamine_level1.87502879
24MP0006276_abnormal_autonomic_nervous1.84323424
25MP0009780_abnormal_chondrocyte_physiolo1.83181409
26MP0005645_abnormal_hypothalamus_physiol1.75535367
27MP0000372_irregular_coat_pigmentation1.75345624
28MP0001188_hyperpigmentation1.73534700
29MP0000566_synostosis1.70587735
30MP0001968_abnormal_touch/_nociception1.65860067
31MP0005379_endocrine/exocrine_gland_phen1.65110039
32MP0002277_abnormal_respiratory_mucosa1.62182039
33MP0009046_muscle_twitch1.61457012
34MP0008872_abnormal_physiological_respon1.58416372
35MP0000778_abnormal_nervous_system1.54555025
36MP0005408_hypopigmentation1.54071160
37MP0008004_abnormal_stomach_pH1.53754992
38MP0005084_abnormal_gallbladder_morpholo1.52086341
39MP0000538_abnormal_urinary_bladder1.49039860
40MP0002095_abnormal_skin_pigmentation1.48436243
41MP0002751_abnormal_autonomic_nervous1.46923784
42MP0003646_muscle_fatigue1.45480742
43MP0008260_abnormal_autophagy1.44749523
44MP0004134_abnormal_chest_morphology1.44565128
45MP0005551_abnormal_eye_electrophysiolog1.44191530
46MP0002163_abnormal_gland_morphology1.43921997
47MP0005174_abnormal_tail_pigmentation1.43801106
48MP0003786_premature_aging1.43420118
49MP0002272_abnormal_nervous_system1.42994316
50MP0006035_abnormal_mitochondrial_morpho1.42650850
51MP0002653_abnormal_ependyma_morphology1.40334063
52MP0001664_abnormal_digestion1.35501575
53MP0000427_abnormal_hair_cycle1.34835358
54MP0000569_abnormal_digit_pigmentation1.34335874
55MP0006072_abnormal_retinal_apoptosis1.34290197
56MP0006292_abnormal_olfactory_placode1.30557490
57MP0005332_abnormal_amino_acid1.29567047
58MP0002938_white_spotting1.26797264
59MP0002735_abnormal_chemical_nociception1.25502169
60MP0003183_abnormal_peptide_metabolism1.25480968
61MP0001502_abnormal_circadian_rhythm1.24635304
62MP0005075_abnormal_melanosome_morpholog1.22954012
63MP0001542_abnormal_bone_strength1.22588416
64MP0002234_abnormal_pharynx_morphology1.20752990
65MP0000920_abnormal_myelination1.20573873
66MP0005503_abnormal_tendon_morphology1.20158432
67MP0005423_abnormal_somatic_nervous1.19606481
68MP0008789_abnormal_olfactory_epithelium1.18874047
69MP0003121_genomic_imprinting1.17208391
70MP0004133_heterotaxia1.15901833
71MP0009697_abnormal_copulation1.15402527
72MP0008995_early_reproductive_senescence1.14784857
73MP0003136_yellow_coat_color1.13521773
74MP0005253_abnormal_eye_physiology1.12722599
75MP0002064_seizures1.11529674
76MP0000681_abnormal_thyroid_gland1.10660987
77MP0002184_abnormal_innervation1.10503538
78MP0005220_abnormal_exocrine_pancreas1.10328874
79MP0002928_abnormal_bile_duct1.09623655
80MP0000749_muscle_degeneration1.09513511
81MP0001970_abnormal_pain_threshold1.08903137
82MP0000631_abnormal_neuroendocrine_gland1.07923133
83MP0002090_abnormal_vision1.06312077
84MP0003283_abnormal_digestive_organ1.05818305
85MP0003634_abnormal_glial_cell1.01295522
86MP0002067_abnormal_sensory_capabilities1.01278685
87MP0004147_increased_porphyrin_level1.01259622
88MP0005085_abnormal_gallbladder_physiolo1.00568107
89MP0005367_renal/urinary_system_phenotyp1.00044624
90MP0000516_abnormal_urinary_system1.00044624
91MP0001501_abnormal_sleep_pattern0.99920065
92MP0002909_abnormal_adrenal_gland0.99852041
93MP0002733_abnormal_thermal_nociception0.99736714
94MP0009384_cardiac_valve_regurgitation0.99723580
95MP0001944_abnormal_pancreas_morphology0.98867798
96MP0003806_abnormal_nucleotide_metabolis0.98610515
97MP0001485_abnormal_pinna_reflex0.98233103
98MP0009745_abnormal_behavioral_response0.98150629
99MP0003252_abnormal_bile_duct0.97503353
100MP0000026_abnormal_inner_ear0.97356743
101MP0002063_abnormal_learning/memory/cond0.97290723
102MP0009250_abnormal_appendicular_skeleto0.96355004
103MP0004742_abnormal_vestibular_system0.96107226
104MP0004782_abnormal_surfactant_physiolog0.95798967
105MP0005389_reproductive_system_phenotype0.94344991
106MP0004272_abnormal_basement_membrane0.94330448
107MP0005410_abnormal_fertilization0.93843625
108MP0002160_abnormal_reproductive_system0.92657319
109MP0002693_abnormal_pancreas_physiology0.92272982
110MP0001764_abnormal_homeostasis0.91290399
111MP0005365_abnormal_bile_salt0.91076835
112MP0006036_abnormal_mitochondrial_physio0.90027397
113MP0008775_abnormal_heart_ventricle0.89381304
114MP0002572_abnormal_emotion/affect_behav0.88808675
115MP0000647_abnormal_sebaceous_gland0.88386857
116MP0003186_abnormal_redox_activity0.88355749
117MP0003693_abnormal_embryo_hatching0.88030482
118MP0001963_abnormal_hearing_physiology0.87795862
119MP0005636_abnormal_mineral_homeostasis0.87574157
120MP0001486_abnormal_startle_reflex0.86988686
121MP0002229_neurodegeneration0.86896917
122MP0003635_abnormal_synaptic_transmissio0.85882661
123MP0005499_abnormal_olfactory_system0.85417097
124MP0005394_taste/olfaction_phenotype0.85417097
125MP0002752_abnormal_somatic_nervous0.84368837
126MP0000230_abnormal_systemic_arterial0.83430597
127MP0001177_atelectasis0.82839768
128MP0002882_abnormal_neuron_morphology0.82568563
129MP0001299_abnormal_eye_distance/0.82283844
130MP0003718_maternal_effect0.82054052
131MP0002210_abnormal_sex_determination0.81978401
132MP0003787_abnormal_imprinting0.81328963
133MP0001324_abnormal_eye_pigmentation0.81107455
134MP0004019_abnormal_vitamin_homeostasis0.80850990
135MP0005195_abnormal_posterior_eye0.80605368
136MP0004885_abnormal_endolymph0.79873995
137MP0001756_abnormal_urination0.79656246
138MP0004142_abnormal_muscle_tone0.78809331
139MP0000678_abnormal_parathyroid_gland0.78804614
140MP0001929_abnormal_gametogenesis0.78685800
141MP0002557_abnormal_social/conspecific_i0.77357071
142MP0003122_maternal_imprinting0.77321772
143MP0004085_abnormal_heartbeat0.76935982

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.07964307
2Abnormal mitochondria in muscle tissue (HP:0008316)4.79396503
3Mitochondrial inheritance (HP:0001427)4.38245054
4Progressive macrocephaly (HP:0004481)4.29332965
5Acute encephalopathy (HP:0006846)4.24415936
6Hepatocellular necrosis (HP:0001404)4.18630890
7Increased serum pyruvate (HP:0003542)4.11093266
8Abnormality of glycolysis (HP:0004366)4.11093266
9Hepatic necrosis (HP:0002605)4.00104066
10Increased CSF lactate (HP:0002490)3.83355078
11Molar tooth sign on MRI (HP:0002419)3.47443369
12Abnormality of midbrain morphology (HP:0002418)3.47443369
13Pheochromocytoma (HP:0002666)3.32409220
14Neuroendocrine neoplasm (HP:0100634)3.31038192
15Renal Fanconi syndrome (HP:0001994)3.24333936
16Nephronophthisis (HP:0000090)3.16019975
17Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.05936146
18Hypothermia (HP:0002045)3.00794521
19Methylmalonic acidemia (HP:0002912)2.88107452
20Type I transferrin isoform profile (HP:0003642)2.80196928
21Respiratory failure (HP:0002878)2.77440148
22Increased hepatocellular lipid droplets (HP:0006565)2.76513449
23Methylmalonic aciduria (HP:0012120)2.75277606
24Congenital stationary night blindness (HP:0007642)2.71616605
25Congenital, generalized hypertrichosis (HP:0004540)2.64855676
26Abnormality of the renal cortex (HP:0011035)2.60851136
27Abnormality of the renal medulla (HP:0100957)2.60403318
28Renal cortical cysts (HP:0000803)2.58408574
29Cerebral edema (HP:0002181)2.50365124
30Lipid accumulation in hepatocytes (HP:0006561)2.48651006
31Exercise intolerance (HP:0003546)2.47725357
32Parakeratosis (HP:0001036)2.47274622
33Lactic acidosis (HP:0003128)2.47048447
34Retinal dysplasia (HP:0007973)2.46953408
35Neoplasm of the adrenal gland (HP:0100631)2.38408491
363-Methylglutaconic aciduria (HP:0003535)2.36297865
37Increased serum lactate (HP:0002151)2.35838913
38Congenital sensorineural hearing impairment (HP:0008527)2.33372692
39Leukodystrophy (HP:0002415)2.31525356
40Lethargy (HP:0001254)2.30795030
41Hyperglycinemia (HP:0002154)2.29682625
42Abnormality of renal resorption (HP:0011038)2.29385089
43Optic disc pallor (HP:0000543)2.28630978
44True hermaphroditism (HP:0010459)2.27863507
45Aplasia/hypoplasia of the uterus (HP:0008684)2.27821189
46Generalized aminoaciduria (HP:0002909)2.27788045
47Ketoacidosis (HP:0001993)2.27024159
48Congenital ichthyosiform erythroderma (HP:0007431)2.26760893
49Patchy hypopigmentation of hair (HP:0011365)2.25634213
50Abnormality of urine glucose concentration (HP:0011016)2.24296129
51Glycosuria (HP:0003076)2.24296129
52Hyperventilation (HP:0002883)2.20554804
53Decreased activity of mitochondrial respiratory chain (HP:0008972)2.18775114
54Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.18775114
55Abnormal protein glycosylation (HP:0012346)2.16880775
56Abnormal glycosylation (HP:0012345)2.16880775
57Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.16880775
58Abnormal protein N-linked glycosylation (HP:0012347)2.16880775
59Medial flaring of the eyebrow (HP:0010747)2.16775422
60CNS demyelination (HP:0007305)2.14477699
61Symptomatic seizures (HP:0011145)2.14056967
62Abnormal rod and cone electroretinograms (HP:0008323)2.13790442
63Abnormal number of erythroid precursors (HP:0012131)2.10289565
64X-linked dominant inheritance (HP:0001423)2.08924632
65Cystic liver disease (HP:0006706)2.08540565
66Increased intramyocellular lipid droplets (HP:0012240)2.08106609
67Hyperphosphaturia (HP:0003109)2.05892442
68Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.05117232
69Hypoplasia of the uterus (HP:0000013)2.04294570
70Abnormal pancreas size (HP:0012094)2.04082739
71Pendular nystagmus (HP:0012043)2.03673465
72Male pseudohermaphroditism (HP:0000037)2.02943278
73Abnormality of aspartate family amino acid metabolism (HP:0010899)2.02817453
74Irregular epiphyses (HP:0010582)2.02597794
75Nephrogenic diabetes insipidus (HP:0009806)2.02307785
76Sclerocornea (HP:0000647)2.01185720
77Attenuation of retinal blood vessels (HP:0007843)2.01100787
78Ketosis (HP:0001946)2.00951060
79Abolished electroretinogram (ERG) (HP:0000550)1.99185181
80Decreased central vision (HP:0007663)1.98926613
81Aplasia/Hypoplasia of the tongue (HP:0010295)1.98682144
82Abnormality of vitamin B metabolism (HP:0004340)1.98235096
83Abnormality of methionine metabolism (HP:0010901)1.95693035
84Type II lissencephaly (HP:0007260)1.95162798
85Gait imbalance (HP:0002141)1.94729217
86Degeneration of the lateral corticospinal tracts (HP:0002314)1.91243899
87Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.91243899
88Furrowed tongue (HP:0000221)1.89747701
89Palpitations (HP:0001962)1.89125089
90Dicarboxylic aciduria (HP:0003215)1.88519450
91Abnormality of dicarboxylic acid metabolism (HP:0010995)1.88519450
92Hypomagnesemia (HP:0002917)1.85761518
93Abnormal biliary tract physiology (HP:0012439)1.85194372
94Bile duct proliferation (HP:0001408)1.85194372
95Large for gestational age (HP:0001520)1.84233321
96Abnormality of macular pigmentation (HP:0008002)1.84225824
97Intestinal atresia (HP:0011100)1.83950089
98Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.83909458
99Colon cancer (HP:0003003)1.82776406
100Abnormality of serum amino acid levels (HP:0003112)1.82109765
101Rimmed vacuoles (HP:0003805)1.82090474
102Abnormality of cells of the erythroid lineage (HP:0012130)1.81670515
103Decreased electroretinogram (ERG) amplitude (HP:0000654)1.80816508
104Abnormal pupillary function (HP:0007686)1.80719868
105Sensory axonal neuropathy (HP:0003390)1.80662974
106Congenital primary aphakia (HP:0007707)1.80543249
107Conjunctival hamartoma (HP:0100780)1.80466281
108Inability to walk (HP:0002540)1.79663121
109Thyroid-stimulating hormone excess (HP:0002925)1.78724270
110Reduced antithrombin III activity (HP:0001976)1.77786640
111Submucous cleft hard palate (HP:0000176)1.77668854
112Pancreatic cysts (HP:0001737)1.76404733
113Renal tubular dysfunction (HP:0000124)1.76379154
114Akinesia (HP:0002304)1.76072599
115Cerebral hypomyelination (HP:0006808)1.73754462
116Abnormal urine phosphate concentration (HP:0012599)1.72162867
117Vaginal atresia (HP:0000148)1.72007672
118Postaxial foot polydactyly (HP:0001830)1.71802253
119Aplasia/Hypoplasia of the tibia (HP:0005772)1.71753429
120Lissencephaly (HP:0001339)1.71659527
121Reticulocytopenia (HP:0001896)1.71439342
122Congenital hepatic fibrosis (HP:0002612)1.71067856
123Abnormality of the vitamin B12 metabolism (HP:0004341)1.69940139
124Genital tract atresia (HP:0001827)1.68641296
125Fibular aplasia (HP:0002990)1.67915429
126Hyperinsulinemic hypoglycemia (HP:0000825)1.67589360
127Delayed epiphyseal ossification (HP:0002663)1.66569433
128Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.65819998
129Abnormality of alanine metabolism (HP:0010916)1.65819998
130Hyperalaninemia (HP:0003348)1.65819998
131Flat capital femoral epiphysis (HP:0003370)1.65636686
132Increased muscle lipid content (HP:0009058)1.65481374
133Hypoglycemic seizures (HP:0002173)1.65272567
134Increased corneal curvature (HP:0100692)1.64990090
135Keratoconus (HP:0000563)1.64990090
136Disproportionate short-trunk short stature (HP:0003521)1.63997558
137Insulin-resistant diabetes mellitus (HP:0000831)1.63209459
138Respiratory difficulties (HP:0002880)1.62995449
139Abnormal hair whorl (HP:0010721)1.62782089
140Pancreatic fibrosis (HP:0100732)1.62448008
141White forelock (HP:0002211)1.62213043
142Hypoglycemic coma (HP:0001325)1.60663707
143Exertional dyspnea (HP:0002875)1.59836214
144Limb dystonia (HP:0002451)1.59641818
145Hypoplastic pelvis (HP:0008839)1.58289327

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.29530447
2VRK23.15855191
3MAP4K23.06626034
4STK162.81223547
5ERBB32.68549915
6BCR2.37226855
7LIMK12.30236620
8BMPR1B2.28533341
9OXSR12.22343487
10AKT32.11103972
11BMPR22.07799340
12INSRR2.04983119
13MUSK2.01859285
14CCNB12.01455293
15NME12.00947582
16ACVR1B1.96306301
17MST41.95021436
18CDK191.93216321
19FRK1.90871310
20DYRK21.88454785
21EIF2AK31.82899897
22NEK11.76327447
23MYLK1.72024784
24GRK11.70736126
25PLK21.68303785
26TAOK31.64843526
27STK391.60283551
28SGK4941.59195255
29SGK2231.59195255
30MARK11.57766788
31TRIM281.53064361
32PRPF4B1.48579548
33VRK11.47949519
34EIF2AK11.45427054
35PINK11.41778476
36MAP2K71.40279628
37SIK31.39253366
38BRAF1.36906020
39NEK61.34619709
40MKNK21.31270627
41MAPK131.27407686
42PBK1.19565840
43ZAK1.11090314
44BUB11.10962073
45MAP3K121.10723801
46SGK21.10033609
47PASK1.08382219
48EPHB21.08163133
49ARAF1.01405220
50PLK40.98917627
51TNIK0.97859800
52MAP3K40.96380579
53WNK40.95292230
54MKNK10.95163264
55WNK30.94701855
56OBSCN0.94358449
57PNCK0.93960556
58PLK30.93272491
59TLK10.91984613
60MAPKAPK50.91583587
61CSNK1G30.91209926
62CAMK2B0.90946781
63YES10.87142896
64TAF10.87086272
65UHMK10.86586520
66PRKCE0.86296768
67MAP3K30.85399852
68BCKDK0.84330204
69ADRBK20.82615511
70PKN10.79743160
71BRSK20.79610906
72PDK20.79212859
73TESK10.78476660
74WEE10.78018099
75MAPK150.77388272
76CAMKK20.76589814
77CAMK2D0.76374594
78TGFBR10.75812768
79TXK0.71332833
80PIK3CA0.71185937
81NME20.70441917
82ILK0.69525869
83LMTK20.68923026
84PLK10.68789062
85EIF2AK20.68482453
86ADRBK10.68026677
87MINK10.66939954
88TIE10.65983621
89PIK3CG0.64969007
90PHKG20.64300165
91PHKG10.64300165
92DYRK1A0.63284283
93CAMK2A0.62703738
94STK30.62319323
95SRPK10.62201051
96PIM20.61689826
97CDK80.61530755
98EPHA40.58826231
99CSNK1G20.58267327
100MAP3K20.56954326
101CSNK1A1L0.56634138
102CAMK2G0.55133198
103PTK2B0.54846602
104ROCK20.53865793
105TAOK20.53673542
106GRK50.52197761
107EPHA30.51782712
108RPS6KA50.51586671
109MET0.51339502
110PRKCG0.50602550
111GRK70.50221738
112STK38L0.46952344
113CSNK1G10.46147341
114CDC70.45511477
115PRKCI0.44810425
116DAPK20.43680615
117MAPKAPK30.42990739
118NUAK10.41881395
119BRSK10.41109708
120TEC0.40122637
121ABL20.40013461
122CSNK1A10.39609357
123PRKCQ0.39265489
124DAPK10.39055709
125CDK50.38918374
126MAP2K60.38452519
127IKBKB0.38049579
128PRKACA0.37644049
129CSNK2A10.36676157
130MAP2K10.36587874
131TSSK60.36321141
132PAK30.36238083
133FGFR20.36066293
134PRKCA0.31501546
135ATR0.31141193

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030605.16363589
2Oxidative phosphorylation_Homo sapiens_hsa001904.30090859
3Parkinsons disease_Homo sapiens_hsa050123.59287601
4Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.47839215
5Proteasome_Homo sapiens_hsa030503.40853761
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.80763079
7Alzheimers disease_Homo sapiens_hsa050102.75035388
8Maturity onset diabetes of the young_Homo sapiens_hsa049502.68602936
9Sulfur metabolism_Homo sapiens_hsa009202.66653348
10Fatty acid elongation_Homo sapiens_hsa000622.61319611
11Huntingtons disease_Homo sapiens_hsa050162.49416648
12Vibrio cholerae infection_Homo sapiens_hsa051102.34913737
13Steroid biosynthesis_Homo sapiens_hsa001002.31662024
14SNARE interactions in vesicular transport_Homo sapiens_hsa041302.21629228
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.10241117
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.10240351
17RNA polymerase_Homo sapiens_hsa030201.98062666
18Homologous recombination_Homo sapiens_hsa034401.95799937
19Collecting duct acid secretion_Homo sapiens_hsa049661.91546856
20Ribosome_Homo sapiens_hsa030101.84199021
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.77866342
22Phototransduction_Homo sapiens_hsa047441.77248652
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.63608469
24Mismatch repair_Homo sapiens_hsa034301.55655525
25Primary bile acid biosynthesis_Homo sapiens_hsa001201.52690958
26Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.50749222
27Fanconi anemia pathway_Homo sapiens_hsa034601.42882443
28Tryptophan metabolism_Homo sapiens_hsa003801.38321472
29One carbon pool by folate_Homo sapiens_hsa006701.37614774
30Nucleotide excision repair_Homo sapiens_hsa034201.28451934
31Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.24669835
32Caffeine metabolism_Homo sapiens_hsa002321.24092537
33Synaptic vesicle cycle_Homo sapiens_hsa047211.22608428
34Butanoate metabolism_Homo sapiens_hsa006501.20697893
35Chemical carcinogenesis_Homo sapiens_hsa052041.19237206
36N-Glycan biosynthesis_Homo sapiens_hsa005101.17046944
37Nitrogen metabolism_Homo sapiens_hsa009101.16111549
38Cardiac muscle contraction_Homo sapiens_hsa042601.14623758
39Regulation of autophagy_Homo sapiens_hsa041401.11157801
40Sulfur relay system_Homo sapiens_hsa041221.09755662
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.08615842
42Ether lipid metabolism_Homo sapiens_hsa005651.06906451
43Sphingolipid metabolism_Homo sapiens_hsa006001.06464644
44Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.06418790
45Rheumatoid arthritis_Homo sapiens_hsa053231.00717402
46Non-homologous end-joining_Homo sapiens_hsa034501.00531609
47Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.00273521
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.98910961
49Serotonergic synapse_Homo sapiens_hsa047260.97115435
50Arachidonic acid metabolism_Homo sapiens_hsa005900.95594870
51Pentose and glucuronate interconversions_Homo sapiens_hsa000400.94757113
52DNA replication_Homo sapiens_hsa030300.93455106
53Phagosome_Homo sapiens_hsa041450.91634562
54beta-Alanine metabolism_Homo sapiens_hsa004100.88288848
55Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.87709947
56Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.86920645
57Purine metabolism_Homo sapiens_hsa002300.83812555
58Cysteine and methionine metabolism_Homo sapiens_hsa002700.82995987
59Insulin secretion_Homo sapiens_hsa049110.77826404
60Base excision repair_Homo sapiens_hsa034100.76754228
61Metabolic pathways_Homo sapiens_hsa011000.76522219
62Taste transduction_Homo sapiens_hsa047420.75837519
63Phenylalanine metabolism_Homo sapiens_hsa003600.75019151
64Glutathione metabolism_Homo sapiens_hsa004800.72348461
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71113356
66Propanoate metabolism_Homo sapiens_hsa006400.69338713
67Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.68883518
68Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.66849321
69Peroxisome_Homo sapiens_hsa041460.66196472
70Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.65110756
71Pyrimidine metabolism_Homo sapiens_hsa002400.64568155
72Tyrosine metabolism_Homo sapiens_hsa003500.64187330
73RNA transport_Homo sapiens_hsa030130.63248759
74Spliceosome_Homo sapiens_hsa030400.60784294
75Other glycan degradation_Homo sapiens_hsa005110.60324455
76Pyruvate metabolism_Homo sapiens_hsa006200.59647024
77Linoleic acid metabolism_Homo sapiens_hsa005910.59599042
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.59250924
79Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58489911
80Basal transcription factors_Homo sapiens_hsa030220.57823629
81Folate biosynthesis_Homo sapiens_hsa007900.57712850
82Drug metabolism - other enzymes_Homo sapiens_hsa009830.56133534
83Circadian rhythm_Homo sapiens_hsa047100.56095975
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.55807411
85Cocaine addiction_Homo sapiens_hsa050300.54953972
86Histidine metabolism_Homo sapiens_hsa003400.54926745
87Mineral absorption_Homo sapiens_hsa049780.54314139
88GABAergic synapse_Homo sapiens_hsa047270.53961816
89Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.53553872
90Dopaminergic synapse_Homo sapiens_hsa047280.53345467
91Axon guidance_Homo sapiens_hsa043600.53089371
92Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52804655
93Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.52441903
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51774911
95Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.51070968
96Olfactory transduction_Homo sapiens_hsa047400.49873265
97Circadian entrainment_Homo sapiens_hsa047130.49122311
98Glycerolipid metabolism_Homo sapiens_hsa005610.48748495
99Arginine and proline metabolism_Homo sapiens_hsa003300.47334341
100Vitamin digestion and absorption_Homo sapiens_hsa049770.45754792
101Type I diabetes mellitus_Homo sapiens_hsa049400.43239311
102Cholinergic synapse_Homo sapiens_hsa047250.43041093
103Morphine addiction_Homo sapiens_hsa050320.40757416
104Lysosome_Homo sapiens_hsa041420.39557082
105Nicotine addiction_Homo sapiens_hsa050330.38333228
106Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.37616520
107Fat digestion and absorption_Homo sapiens_hsa049750.35060616
108alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.34131785
109Amphetamine addiction_Homo sapiens_hsa050310.33911474
110Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.33513018
111Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.33327560
112Asthma_Homo sapiens_hsa053100.33315064
113Fatty acid metabolism_Homo sapiens_hsa012120.33192946
114Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.28718071
115Pancreatic secretion_Homo sapiens_hsa049720.27449207
116Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.24557341
117Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.23262010
118Glutamatergic synapse_Homo sapiens_hsa047240.22926128
119ABC transporters_Homo sapiens_hsa020100.22403962
120Ovarian steroidogenesis_Homo sapiens_hsa049130.22284299
121Steroid hormone biosynthesis_Homo sapiens_hsa001400.21582230
122Autoimmune thyroid disease_Homo sapiens_hsa053200.19686493
123Long-term depression_Homo sapiens_hsa047300.17433370
124Fatty acid degradation_Homo sapiens_hsa000710.17302104
125Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.17083301
126Tight junction_Homo sapiens_hsa045300.13456164
127Alcoholism_Homo sapiens_hsa050340.11733011
128Galactose metabolism_Homo sapiens_hsa000520.10903664
129Selenocompound metabolism_Homo sapiens_hsa004500.10403015
130RNA degradation_Homo sapiens_hsa030180.10116243
131Retinol metabolism_Homo sapiens_hsa008300.09823162
132Renin secretion_Homo sapiens_hsa049240.08502006
133Vitamin B6 metabolism_Homo sapiens_hsa007500.08489122
134Carbon metabolism_Homo sapiens_hsa012000.08232493

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