SMIM8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.32161278
2ATP synthesis coupled proton transport (GO:0015986)6.94184673
3energy coupled proton transport, down electrochemical gradient (GO:0015985)6.94184673
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.85783379
5axon ensheathment in central nervous system (GO:0032291)6.40722435
6central nervous system myelination (GO:0022010)6.40722435
7respiratory electron transport chain (GO:0022904)6.12100108
8electron transport chain (GO:0022900)6.02031380
9fatty acid elongation (GO:0030497)5.69986538
10chaperone-mediated protein transport (GO:0072321)5.25879774
11mitochondrial respiratory chain complex I assembly (GO:0032981)4.93324456
12NADH dehydrogenase complex assembly (GO:0010257)4.93324456
13mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.93324456
14protein complex biogenesis (GO:0070271)4.78152900
15protein neddylation (GO:0045116)4.52855194
16mitochondrial respiratory chain complex assembly (GO:0033108)4.27867315
17long-chain fatty acid biosynthetic process (GO:0042759)4.17288154
18GTP biosynthetic process (GO:0006183)4.06019719
19hydrogen ion transmembrane transport (GO:1902600)3.94245916
20purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.93682241
21purine nucleoside triphosphate biosynthetic process (GO:0009145)3.91507196
22ATP biosynthetic process (GO:0006754)3.90157248
23behavioral response to nicotine (GO:0035095)3.89463366
24establishment of protein localization to mitochondrial membrane (GO:0090151)3.82149817
25GPI anchor biosynthetic process (GO:0006506)3.72882721
26respiratory chain complex IV assembly (GO:0008535)3.66440942
27proton transport (GO:0015992)3.64412406
28hydrogen transport (GO:0006818)3.60008604
29DNA double-strand break processing (GO:0000729)3.50579856
30cholesterol biosynthetic process (GO:0006695)3.50229899
31nonmotile primary cilium assembly (GO:0035058)3.49008427
32substantia nigra development (GO:0021762)3.47896346
33protein localization to cilium (GO:0061512)3.44406836
34ribosomal small subunit biogenesis (GO:0042274)3.44330161
35water-soluble vitamin biosynthetic process (GO:0042364)3.42222035
36ribonucleoside triphosphate biosynthetic process (GO:0009201)3.40936317
37inner mitochondrial membrane organization (GO:0007007)3.40052365
38epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.34215597
39UTP biosynthetic process (GO:0006228)3.32582535
40proteasome assembly (GO:0043248)3.30917489
41GPI anchor metabolic process (GO:0006505)3.27717819
42signal peptide processing (GO:0006465)3.25835079
43oxidative phosphorylation (GO:0006119)3.24335999
44response to methylmercury (GO:0051597)3.23631524
45myelination (GO:0042552)3.20579953
46response to pheromone (GO:0019236)3.20251135
47axonemal dynein complex assembly (GO:0070286)3.17360191
48platelet dense granule organization (GO:0060155)3.16017240
49preassembly of GPI anchor in ER membrane (GO:0016254)3.15115741
50ensheathment of neurons (GO:0007272)3.12886196
51axon ensheathment (GO:0008366)3.12886196
52nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.11002535
53sterol biosynthetic process (GO:0016126)3.09506753
54exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.07717199
55neural tube formation (GO:0001841)3.05962942
56cullin deneddylation (GO:0010388)3.05828874
57cotranslational protein targeting to membrane (GO:0006613)3.05205611
58DNA deamination (GO:0045006)3.03125644
59nucleoside triphosphate biosynthetic process (GO:0009142)3.02303577
60mannosylation (GO:0097502)3.02301555
61negative regulation of DNA-dependent DNA replication (GO:2000104)3.02029753
62negative regulation of protein localization to cell surface (GO:2000009)3.01891421
63transcription elongation from RNA polymerase III promoter (GO:0006385)3.00698972
64termination of RNA polymerase III transcription (GO:0006386)3.00698972
65regulation of cilium movement (GO:0003352)2.99950275
66UTP metabolic process (GO:0046051)2.99265780
67cilium morphogenesis (GO:0060271)2.97427942
68establishment of integrated proviral latency (GO:0075713)2.97065571
69aerobic respiration (GO:0009060)2.97061079
70positive regulation of cellular amine metabolic process (GO:0033240)2.95315826
71protein targeting to ER (GO:0045047)2.94142354
72protein-cofactor linkage (GO:0018065)2.93163170
73intraciliary transport (GO:0042073)2.93146565
74regulation of collateral sprouting (GO:0048670)2.92778940
75cilium organization (GO:0044782)2.91547310
76prenylation (GO:0097354)2.90252374
77protein prenylation (GO:0018342)2.90252374
78protein localization to endoplasmic reticulum (GO:0070972)2.89892065
79cytochrome complex assembly (GO:0017004)2.88906966
80axoneme assembly (GO:0035082)2.88745771
81SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.88631813
82nucleoside diphosphate phosphorylation (GO:0006165)2.88118442
83protein polyglutamylation (GO:0018095)2.88047251
84guanosine-containing compound biosynthetic process (GO:1901070)2.87983715
85cilium assembly (GO:0042384)2.86986420
867-methylguanosine mRNA capping (GO:0006370)2.86598398
87dopamine transport (GO:0015872)2.85610971
88viral transcription (GO:0019083)2.85577598
897-methylguanosine RNA capping (GO:0009452)2.84884360
90RNA capping (GO:0036260)2.84884360
91protein targeting to mitochondrion (GO:0006626)2.84551656
92presynaptic membrane assembly (GO:0097105)2.83777903
93epithelial cilium movement (GO:0003351)2.82497833
94establishment of protein localization to endoplasmic reticulum (GO:0072599)2.82220429
95neurotransmitter uptake (GO:0001504)2.81115273
96protein deneddylation (GO:0000338)2.80890093
97photoreceptor cell maintenance (GO:0045494)2.80781266
98isoprenoid biosynthetic process (GO:0008299)2.80342847
99establishment of viral latency (GO:0019043)2.80179669
100detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.80170913
101response to redox state (GO:0051775)2.77807475
102peptidyl-histidine modification (GO:0018202)2.77802581
103negative regulation of execution phase of apoptosis (GO:1900118)2.77457985
104nucleotide transmembrane transport (GO:1901679)2.77256565
105cellular ketone body metabolic process (GO:0046950)2.76304300
106oligodendrocyte differentiation (GO:0048709)2.74177346
107neuron cell-cell adhesion (GO:0007158)2.72692131
108replication fork processing (GO:0031297)2.72341198
109negative regulation of neurotransmitter transport (GO:0051589)2.72260830
110long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.72192023
111regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.71915088
112regulation of mitotic spindle checkpoint (GO:1903504)2.71915088
113translational termination (GO:0006415)2.71778810
114CTP biosynthetic process (GO:0006241)2.70935818
115CTP metabolic process (GO:0046036)2.70935818
116regulation of meiosis I (GO:0060631)2.70069311
117presynaptic membrane organization (GO:0097090)2.69488857
118pyrimidine nucleobase catabolic process (GO:0006208)2.67476713
119cilium movement (GO:0003341)2.67191392
120establishment of protein localization to mitochondrion (GO:0072655)2.67147683
121positive regulation of protein homodimerization activity (GO:0090073)2.66618232
122long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.63722843
123regulation of mitochondrial translation (GO:0070129)2.62746125
124regulation of hexokinase activity (GO:1903299)2.62434748
125regulation of glucokinase activity (GO:0033131)2.62434748
126intracellular protein transmembrane import (GO:0044743)2.61327578
127retinal cone cell development (GO:0046549)2.61116247
128fucose catabolic process (GO:0019317)2.60591968
129L-fucose metabolic process (GO:0042354)2.60591968
130L-fucose catabolic process (GO:0042355)2.60591968
131regulation of cellular amino acid metabolic process (GO:0006521)2.59848959
132recombinational repair (GO:0000725)2.58678543
133rRNA modification (GO:0000154)2.57984796
134double-strand break repair via homologous recombination (GO:0000724)2.55472059
135regulation of catecholamine metabolic process (GO:0042069)2.54781685
136regulation of dopamine metabolic process (GO:0042053)2.54781685
137magnesium ion transport (GO:0015693)2.54121491
138creatine metabolic process (GO:0006600)2.54030701
139regulation of action potential (GO:0098900)2.50915962
140organelle disassembly (GO:1903008)2.50111268
141negative regulation of heart rate (GO:0010459)2.49933698
142RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.48595066
143tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.48595066
144ketone body metabolic process (GO:1902224)2.47905740
145negative regulation of transcription regulatory region DNA binding (GO:2000678)2.47727874
146rRNA methylation (GO:0031167)2.46393573
147transmission of nerve impulse (GO:0019226)2.44924015
148behavioral response to ethanol (GO:0048149)2.41793061
149somatic diversification of immune receptors via somatic mutation (GO:0002566)2.41345009
150somatic hypermutation of immunoglobulin genes (GO:0016446)2.41345009
151RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.40503938
152histone H2A acetylation (GO:0043968)2.39736856
153anterograde synaptic vesicle transport (GO:0048490)2.38588173
154nucleobase catabolic process (GO:0046113)2.37869375
155kidney morphogenesis (GO:0060993)2.37771792
156positive regulation of mitochondrial fission (GO:0090141)2.37034748
157ubiquinone metabolic process (GO:0006743)2.36431604
158resolution of meiotic recombination intermediates (GO:0000712)2.33836391
159indolalkylamine metabolic process (GO:0006586)2.33747209
160reciprocal DNA recombination (GO:0035825)2.33611618
161reciprocal meiotic recombination (GO:0007131)2.33611618
162regulation of neurotransmitter uptake (GO:0051580)2.32804902
163histone mRNA metabolic process (GO:0008334)2.32711496
164ubiquinone biosynthetic process (GO:0006744)2.32369210

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.63393488
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.51072877
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.38509101
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.29068132
5ZNF274_21170338_ChIP-Seq_K562_Hela3.18702478
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.17194285
7EZH2_22144423_ChIP-Seq_EOC_Human2.93171490
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.85430130
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.83321643
10VDR_22108803_ChIP-Seq_LS180_Human2.61800721
11TAF15_26573619_Chip-Seq_HEK293_Human2.60615637
12IGF1R_20145208_ChIP-Seq_DFB_Human2.58666035
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.54018050
14PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.50240650
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.48165714
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.47804357
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.43100316
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.40692588
19GBX2_23144817_ChIP-Seq_PC3_Human2.34806967
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.17486354
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.14280480
22ZFP57_27257070_Chip-Seq_ESCs_Mouse2.14110351
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.09017418
24CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.08411729
25SRF_21415370_ChIP-Seq_HL-1_Mouse1.96011050
26SALL1_21062744_ChIP-ChIP_HESCs_Human1.95547673
27FUS_26573619_Chip-Seq_HEK293_Human1.88302373
28CREB1_15753290_ChIP-ChIP_HEK293T_Human1.86918092
29ETS1_20019798_ChIP-Seq_JURKAT_Human1.85480427
30POU3F2_20337985_ChIP-ChIP_501MEL_Human1.78512730
31FLI1_27457419_Chip-Seq_LIVER_Mouse1.66967689
32SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.66608465
33PCGF2_27294783_Chip-Seq_ESCs_Mouse1.66460490
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.62316519
35AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.62188873
36RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.54478082
37PIAS1_25552417_ChIP-Seq_VCAP_Human1.53198530
38SMAD4_21799915_ChIP-Seq_A2780_Human1.52698817
39BP1_19119308_ChIP-ChIP_Hs578T_Human1.50883564
40IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.50462932
41CBP_20019798_ChIP-Seq_JUKART_Human1.50462932
42ER_23166858_ChIP-Seq_MCF-7_Human1.50458081
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.49483800
44MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.48156061
45MYC_18940864_ChIP-ChIP_HL60_Human1.47809457
46SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.44630517
47CTBP2_25329375_ChIP-Seq_LNCAP_Human1.42279047
48BCAT_22108803_ChIP-Seq_LS180_Human1.41958791
49EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.41848294
50P300_19829295_ChIP-Seq_ESCs_Human1.39832555
51AR_25329375_ChIP-Seq_VCAP_Human1.39599386
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39257283
53GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37527439
54PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.37184879
55CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.36075112
56TP53_22573176_ChIP-Seq_HFKS_Human1.35703436
57TAL1_26923725_Chip-Seq_HPCs_Mouse1.34896632
58STAT3_23295773_ChIP-Seq_U87_Human1.34131015
59BMI1_23680149_ChIP-Seq_NPCS_Mouse1.33526683
60RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32875180
61OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31618008
62VDR_23849224_ChIP-Seq_CD4+_Human1.29076386
63TCF4_23295773_ChIP-Seq_U87_Human1.26671560
64HTT_18923047_ChIP-ChIP_STHdh_Human1.25861021
65THAP11_20581084_ChIP-Seq_MESCs_Mouse1.24820696
66TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24179040
67POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.24179040
68ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.22789242
69PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.21666038
70ELK1_19687146_ChIP-ChIP_HELA_Human1.21423514
71KLF5_20875108_ChIP-Seq_MESCs_Mouse1.20903938
72NR3C1_21868756_ChIP-Seq_MCF10A_Human1.20266136
73TCF4_22108803_ChIP-Seq_LS180_Human1.18873253
74NOTCH1_21737748_ChIP-Seq_TLL_Human1.17562626
75POU5F1_16153702_ChIP-ChIP_HESCs_Human1.15595431
76PADI4_21655091_ChIP-ChIP_MCF-7_Human1.15016599
77EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.14856571
78RUNX2_22187159_ChIP-Seq_PCA_Human1.14478528
79FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.12587506
80SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.11448134
81PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11073863
82JARID2_20064375_ChIP-Seq_MESCs_Mouse1.09962319
83FOXA1_25329375_ChIP-Seq_VCAP_Human1.09845321
84FOXA1_27270436_Chip-Seq_PROSTATE_Human1.09845321
85FLI1_21867929_ChIP-Seq_TH2_Mouse1.09463311
86ELF1_17652178_ChIP-ChIP_JURKAT_Human1.08401633
87SUZ12_18555785_Chip-Seq_ESCs_Mouse1.08311487
88EWS_26573619_Chip-Seq_HEK293_Human1.07870656
89RNF2_27304074_Chip-Seq_NSC_Mouse1.07498905
90STAT3_18555785_Chip-Seq_ESCs_Mouse1.07199460
91YY1_21170310_ChIP-Seq_MESCs_Mouse1.06908003
92CMYC_18555785_Chip-Seq_ESCs_Mouse1.06578999
93P300_18555785_Chip-Seq_ESCs_Mouse1.06508750
94EZH2_27304074_Chip-Seq_ESCs_Mouse1.06278740
95CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05854955
96FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.05854430
97EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.05574237
98IRF1_19129219_ChIP-ChIP_H3396_Human1.05352529
99NANOG_18555785_Chip-Seq_ESCs_Mouse1.05315389
100REST_21632747_ChIP-Seq_MESCs_Mouse1.05053766
101RBPJ_22232070_ChIP-Seq_NCS_Mouse1.04549647
102TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03081879
103P53_22387025_ChIP-Seq_ESCs_Mouse1.02904426
104PRDM14_20953172_ChIP-Seq_ESCs_Human1.02727580
105SMAD4_21741376_ChIP-Seq_EPCs_Human1.02682154
106FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02360556
107NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.01223047
108ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.00401381
109SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00277492
110PCGF2_27294783_Chip-Seq_NPCs_Mouse0.99930815
111RUNX1_27457419_Chip-Seq_LIVER_Mouse0.99190634
112FOXP3_21729870_ChIP-Seq_TREG_Human0.98798944
113UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98130155
114NANOG_19829295_ChIP-Seq_ESCs_Human0.97677581
115SOX2_19829295_ChIP-Seq_ESCs_Human0.97677581
116MYC_18358816_ChIP-ChIP_MESCs_Mouse0.97160611
117TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95317558
118SMAD3_21741376_ChIP-Seq_EPCs_Human0.95216373
119EZH2_27294783_Chip-Seq_NPCs_Mouse0.95133067
120SOX2_18555785_Chip-Seq_ESCs_Mouse0.94591718
121ETV2_25802403_ChIP-Seq_MESCs_Mouse0.94462576
122HOXB4_20404135_ChIP-ChIP_EML_Mouse0.94188280
123FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.93815325
124NFE2_27457419_Chip-Seq_LIVER_Mouse0.93222562
125GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.93104673
126DCP1A_22483619_ChIP-Seq_HELA_Human0.93029577
127MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.92180171
128KLF4_18555785_Chip-Seq_ESCs_Mouse0.91410991
129SMAD1_18555785_Chip-Seq_ESCs_Mouse0.91055456
130NMYC_18555785_Chip-Seq_ESCs_Mouse0.90324485
131ELK1_22589737_ChIP-Seq_MCF10A_Human0.89279829
132SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.88453916
133E2F1_18555785_Chip-Seq_ESCs_Mouse0.88431951
134PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.88294226
135GATA1_22025678_ChIP-Seq_K562_Human0.87896934
136LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.86634307
137CRX_20693478_ChIP-Seq_RETINA_Mouse0.86183499
138LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86018914
139REST_19997604_ChIP-ChIP_NEURONS_Mouse0.85993878
140ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.85852991
141EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.85175002
142SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.84954753

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.79349479
2MP0001529_abnormal_vocalization3.38362739
3MP0008877_abnormal_DNA_methylation3.28519337
4MP0001984_abnormal_olfaction3.14314728
5MP0009379_abnormal_foot_pigmentation3.00495949
6MP0001905_abnormal_dopamine_level2.98523026
7MP0000920_abnormal_myelination2.85813478
8MP0005410_abnormal_fertilization2.77844657
9MP0004270_analgesia2.66442807
10MP0003136_yellow_coat_color2.64468337
11MP0003011_delayed_dark_adaptation2.45011702
12MP0002102_abnormal_ear_morphology2.41823878
13MP0003806_abnormal_nucleotide_metabolis2.39443765
14MP0005171_absent_coat_pigmentation2.37232222
15MP0003787_abnormal_imprinting2.35345677
16MP0005423_abnormal_somatic_nervous2.28117005
17MP0001986_abnormal_taste_sensitivity2.26644368
18MP0002837_dystrophic_cardiac_calcinosis2.14568523
19MP0004142_abnormal_muscle_tone2.10139792
20MP0006036_abnormal_mitochondrial_physio2.08769983
21MP0008058_abnormal_DNA_repair2.05544572
22MP0002272_abnormal_nervous_system2.03038448
23MP0005409_darkened_coat_color2.03001392
24MP0004043_abnormal_pH_regulation1.96745058
25MP0000372_irregular_coat_pigmentation1.81082375
26MP0006276_abnormal_autonomic_nervous1.80679861
27MP0002736_abnormal_nociception_after1.80443269
28MP0004147_increased_porphyrin_level1.80171061
29MP0005379_endocrine/exocrine_gland_phen1.76255039
30MP0002734_abnormal_mechanical_nocicepti1.71662836
31MP0003195_calcinosis1.70999255
32MP0001485_abnormal_pinna_reflex1.70429122
33MP0000569_abnormal_digit_pigmentation1.69967656
34MP0003950_abnormal_plasma_membrane1.58686775
35MP0001968_abnormal_touch/_nociception1.57788505
36MP0005084_abnormal_gallbladder_morpholo1.57716174
37MP0004381_abnormal_hair_follicle1.53836278
38MP0004133_heterotaxia1.51667603
39MP0002064_seizures1.50510694
40MP0003121_genomic_imprinting1.49136195
41MP0005551_abnormal_eye_electrophysiolog1.47614400
42MP0004742_abnormal_vestibular_system1.46533731
43MP0001486_abnormal_startle_reflex1.46379384
44MP0008872_abnormal_physiological_respon1.44750095
45MP0003122_maternal_imprinting1.42185988
46MP0000749_muscle_degeneration1.42105873
47MP0009745_abnormal_behavioral_response1.40077138
48MP0001970_abnormal_pain_threshold1.37243975
49MP0005451_abnormal_body_composition1.36442789
50MP0002638_abnormal_pupillary_reflex1.33687812
51MP0006035_abnormal_mitochondrial_morpho1.31181473
52MP0008995_early_reproductive_senescence1.29442939
53MP0002229_neurodegeneration1.27577929
54MP0001661_extended_life_span1.26850093
55MP0005174_abnormal_tail_pigmentation1.26138773
56MP0002572_abnormal_emotion/affect_behav1.24910935
57MP0009046_muscle_twitch1.24594290
58MP0002938_white_spotting1.23716024
59MP0004145_abnormal_muscle_electrophysio1.22860707
60MP0005646_abnormal_pituitary_gland1.22504022
61MP0003186_abnormal_redox_activity1.21948329
62MP0006292_abnormal_olfactory_placode1.21245718
63MP0003890_abnormal_embryonic-extraembry1.20595141
64MP0002163_abnormal_gland_morphology1.20398577
65MP0006072_abnormal_retinal_apoptosis1.19061965
66MP0008789_abnormal_olfactory_epithelium1.18993385
67MP0002928_abnormal_bile_duct1.18777785
68MP0002735_abnormal_chemical_nociception1.17976221
69MP0000427_abnormal_hair_cycle1.16416993
70MP0005408_hypopigmentation1.15718239
71MP0003634_abnormal_glial_cell1.14337594
72MP0004036_abnormal_muscle_relaxation1.13955156
73MP0004215_abnormal_myocardial_fiber1.13334152
74MP0001440_abnormal_grooming_behavior1.11969024
75MP0002160_abnormal_reproductive_system1.11428542
76MP0009697_abnormal_copulation1.10710225
77MP0005075_abnormal_melanosome_morpholog1.09747224
78MP0001293_anophthalmia1.09740123
79MP0003635_abnormal_synaptic_transmissio1.08349218
80MP0003329_amyloid_beta_deposits1.08051671
81MP0002067_abnormal_sensory_capabilities1.07474928
82MP0002132_abnormal_respiratory_system1.06916194
83MP0000778_abnormal_nervous_system1.06612529
84MP0003137_abnormal_impulse_conducting1.06003563
85MP0003646_muscle_fatigue1.05365898
86MP0002733_abnormal_thermal_nociception1.05068118
87MP0002752_abnormal_somatic_nervous1.04994342
88MP0001963_abnormal_hearing_physiology1.03945887
89MP0001188_hyperpigmentation1.03758068
90MP0002653_abnormal_ependyma_morphology1.03478265
91MP0010386_abnormal_urinary_bladder1.02333526
92MP0002822_catalepsy1.01556832
93MP0002095_abnormal_skin_pigmentation0.99759843
94MP0002184_abnormal_innervation0.99456936
95MP0005645_abnormal_hypothalamus_physiol0.98481362
96MP0005253_abnormal_eye_physiology0.98109578
97MP0010094_abnormal_chromosome_stability0.97973655
98MP0002751_abnormal_autonomic_nervous0.97509613
99MP0002234_abnormal_pharynx_morphology0.96867695
100MP0008875_abnormal_xenobiotic_pharmacok0.96006050
101MP0003656_abnormal_erythrocyte_physiolo0.95053082
102MP0001501_abnormal_sleep_pattern0.92505200
103MP0003698_abnormal_male_reproductive0.91988509
104MP0002876_abnormal_thyroid_physiology0.90056457
105MP0005389_reproductive_system_phenotype0.89403804
106MP0004134_abnormal_chest_morphology0.88462105
107MP0005636_abnormal_mineral_homeostasis0.88343671
108MP0005187_abnormal_penis_morphology0.86944654
109MP0002909_abnormal_adrenal_gland0.86802941
110MP0000015_abnormal_ear_pigmentation0.85872255
111MP0005391_vision/eye_phenotype0.85826299
112MP0002882_abnormal_neuron_morphology0.85203957
113MP0005394_taste/olfaction_phenotype0.84569449
114MP0005499_abnormal_olfactory_system0.84569449
115MP0000026_abnormal_inner_ear0.83710157
116MP0003690_abnormal_glial_cell0.83188091
117MP0005330_cardiomyopathy0.82397157
118MP0005386_behavior/neurological_phenoty0.81498918
119MP0004924_abnormal_behavior0.81498918
120MP0002066_abnormal_motor_capabilities/c0.78750391
121MP0004885_abnormal_endolymph0.75804230
122MP0002063_abnormal_learning/memory/cond0.75676287
123MP0001929_abnormal_gametogenesis0.74298942
124MP0008569_lethality_at_weaning0.71495316
125MP0000631_abnormal_neuroendocrine_gland0.70052507
126MP0002557_abnormal_social/conspecific_i0.69564283
127MP0005195_abnormal_posterior_eye0.67488754
128MP0003718_maternal_effect0.66487276
129MP0001764_abnormal_homeostasis0.63869905
130MP0000747_muscle_weakness0.63809009
131MP0003938_abnormal_ear_development0.63637648

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.10728484
2Abnormal mitochondria in muscle tissue (HP:0008316)5.66796124
3Mitochondrial inheritance (HP:0001427)5.34799989
4Acute encephalopathy (HP:0006846)5.05607671
5Progressive macrocephaly (HP:0004481)5.05226429
6Hepatocellular necrosis (HP:0001404)4.81741120
7Increased CSF lactate (HP:0002490)4.47499846
8Increased hepatocellular lipid droplets (HP:0006565)4.29531978
9Renal Fanconi syndrome (HP:0001994)4.23212499
10Hepatic necrosis (HP:0002605)4.21719602
11Lipid accumulation in hepatocytes (HP:0006561)3.96316259
123-Methylglutaconic aciduria (HP:0003535)3.86622212
13Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.78718255
14Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.58397822
15Increased intramyocellular lipid droplets (HP:0012240)3.55370686
16Leukodystrophy (HP:0002415)3.55107437
17Abnormality of glycolysis (HP:0004366)3.44822222
18Increased serum pyruvate (HP:0003542)3.44822222
19Abnormality of midbrain morphology (HP:0002418)3.44537793
20Molar tooth sign on MRI (HP:0002419)3.44537793
21Decreased activity of mitochondrial respiratory chain (HP:0008972)3.36555875
22Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.36555875
23Cerebral edema (HP:0002181)3.35827579
24Nephronophthisis (HP:0000090)3.33199011
25Parakeratosis (HP:0001036)3.30689032
26Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.29771429
27Exercise intolerance (HP:0003546)3.20420196
28Respiratory failure (HP:0002878)3.19575537
29Optic disc pallor (HP:0000543)3.17448737
30Lactic acidosis (HP:0003128)3.13968635
31Abnormality of the labia minora (HP:0012880)3.11594848
32Increased muscle lipid content (HP:0009058)3.08504416
33Abnormality of renal resorption (HP:0011038)3.05275493
34Dynein arm defect of respiratory motile cilia (HP:0012255)3.02969650
35Absent/shortened dynein arms (HP:0200106)3.02969650
36Abnormal respiratory motile cilium physiology (HP:0012261)2.98836908
37Increased serum lactate (HP:0002151)2.93741320
38Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.86325503
39Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.86183031
40Degeneration of the lateral corticospinal tracts (HP:0002314)2.86183031
41Abnormal respiratory epithelium morphology (HP:0012253)2.80316215
42Abnormal respiratory motile cilium morphology (HP:0005938)2.80316215
43Neuroendocrine neoplasm (HP:0100634)2.79828631
44Abnormal ciliary motility (HP:0012262)2.79297174
45Abnormality of the renal medulla (HP:0100957)2.78071993
46Abnormality of the renal cortex (HP:0011035)2.68519230
47Cystic liver disease (HP:0006706)2.66767960
48Exertional dyspnea (HP:0002875)2.64491974
49Medial flaring of the eyebrow (HP:0010747)2.63545530
50Abnormality of cells of the erythroid lineage (HP:0012130)2.58830184
51Renal cortical cysts (HP:0000803)2.52077432
52Type II lissencephaly (HP:0007260)2.45026551
53Rhinitis (HP:0012384)2.42808967
54Congenital stationary night blindness (HP:0007642)2.41211764
55Respiratory difficulties (HP:0002880)2.39901904
56Pheochromocytoma (HP:0002666)2.39455580
57Hyperglycinemia (HP:0002154)2.39185068
58Microvesicular hepatic steatosis (HP:0001414)2.35437051
59Abnormal number of erythroid precursors (HP:0012131)2.30782904
60Intestinal atresia (HP:0011100)2.30290990
61Retinal dysplasia (HP:0007973)2.30017839
62Hypothermia (HP:0002045)2.25388114
63Chronic hepatic failure (HP:0100626)2.23920111
64Aplasia/Hypoplasia of the tongue (HP:0010295)2.21567302
65X-linked dominant inheritance (HP:0001423)2.21502221
66Febrile seizures (HP:0002373)2.21140917
67Sclerocornea (HP:0000647)2.20983382
68Colon cancer (HP:0003003)2.20327702
69Congenital primary aphakia (HP:0007707)2.15202817
70Gait imbalance (HP:0002141)2.14539121
71Progressive cerebellar ataxia (HP:0002073)2.13609908
72Sensory axonal neuropathy (HP:0003390)2.13374205
73Poor coordination (HP:0002370)2.12513395
74Gaze-evoked nystagmus (HP:0000640)2.10603608
75Attenuation of retinal blood vessels (HP:0007843)2.09554750
76Methylmalonic acidemia (HP:0002912)2.09405251
77Patchy hypopigmentation of hair (HP:0011365)2.07826083
78Cerebral hypomyelination (HP:0006808)2.06477915
79Nephrogenic diabetes insipidus (HP:0009806)2.06304839
80Type I transferrin isoform profile (HP:0003642)2.05779637
81Peripheral hypomyelination (HP:0007182)2.05685743
82Broad-based gait (HP:0002136)2.03409669
83Abnormality of urine glucose concentration (HP:0011016)2.03389595
84Glycosuria (HP:0003076)2.03389595
85Postaxial hand polydactyly (HP:0001162)2.03080494
86Oligodactyly (hands) (HP:0001180)2.02939105
87Optic nerve hypoplasia (HP:0000609)2.02550491
88Cerebral hemorrhage (HP:0001342)2.01709835
89Postaxial foot polydactyly (HP:0001830)2.01300837
90Anencephaly (HP:0002323)1.99991320
91CNS demyelination (HP:0007305)1.97844080
92Hyperphosphaturia (HP:0003109)1.93756188
93Congenital ichthyosiform erythroderma (HP:0007431)1.93660919
94Aplasia/Hypoplasia of the tibia (HP:0005772)1.92660821
95Male pseudohermaphroditism (HP:0000037)1.91930811
96Abnormal drinking behavior (HP:0030082)1.91859487
97Polydipsia (HP:0001959)1.91859487
98Congenital, generalized hypertrichosis (HP:0004540)1.91856472
99Large for gestational age (HP:0001520)1.91788907
100Bile duct proliferation (HP:0001408)1.91361878
101Abnormal biliary tract physiology (HP:0012439)1.91361878
102Vaginal atresia (HP:0000148)1.89802651
103Spastic paraparesis (HP:0002313)1.89202737
104Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.89115801
105Inability to walk (HP:0002540)1.88988245
106Furrowed tongue (HP:0000221)1.88832567
107Hypoplastic pelvis (HP:0008839)1.87337864
108Emotional lability (HP:0000712)1.87184221
109Hyperventilation (HP:0002883)1.86772227
110Occipital encephalocele (HP:0002085)1.85566246
111Aplasia/hypoplasia of the uterus (HP:0008684)1.85287786
112Congenital hepatic fibrosis (HP:0002612)1.85203868
113Hypomagnesemia (HP:0002917)1.85068705
114Abnormal rod and cone electroretinograms (HP:0008323)1.84965178
115Genital tract atresia (HP:0001827)1.84719531
116Pendular nystagmus (HP:0012043)1.84209342
117Abnormality of the heme biosynthetic pathway (HP:0010472)1.82603299
118Chronic bronchitis (HP:0004469)1.81914503
119Renal tubular dysfunction (HP:0000124)1.81839642
120True hermaphroditism (HP:0010459)1.80599897
121Neurofibrillary tangles (HP:0002185)1.79964613
122White forelock (HP:0002211)1.79219335
123Lethargy (HP:0001254)1.79148496
124Limb dystonia (HP:0002451)1.77653352
125Abnormal protein N-linked glycosylation (HP:0012347)1.77553736
126Abnormal protein glycosylation (HP:0012346)1.77553736
127Abnormal glycosylation (HP:0012345)1.77553736
128Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.77553736
129Abnormality of vitamin B metabolism (HP:0004340)1.77113901
130Abolished electroretinogram (ERG) (HP:0000550)1.75176234
131Absent septum pellucidum (HP:0001331)1.73411133
132Hemiparesis (HP:0001269)1.73066655
133Abnormality of the corticospinal tract (HP:0002492)1.72995742
134Methylmalonic aciduria (HP:0012120)1.72610012
135Supernumerary spleens (HP:0009799)1.72557686
136Aplasia/Hypoplasia of the uvula (HP:0010293)1.71527829
137Cerebellar dysplasia (HP:0007033)1.71503659
138Focal motor seizures (HP:0011153)1.71358558
139Abnormal urine phosphate concentration (HP:0012599)1.70396921
140Lissencephaly (HP:0001339)1.70363510
141Abnormality of secondary sexual hair (HP:0009888)1.69565474
142Abnormality of the axillary hair (HP:0100134)1.69565474
143Pancreatic cysts (HP:0001737)1.67948123
144Pancreatic fibrosis (HP:0100732)1.67711118
145Tubular atrophy (HP:0000092)1.67212923
146Fair hair (HP:0002286)1.65223384
147Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.65017224
148Abnormality of alanine metabolism (HP:0010916)1.65017224
149Hyperalaninemia (HP:0003348)1.65017224
150Narrow forehead (HP:0000341)1.64652503
151Abnormality of the septum pellucidum (HP:0007375)1.64102984
152Short tibia (HP:0005736)1.63489023
153Abnormality of chromosome stability (HP:0003220)1.63248708
154Abnormal pupillary function (HP:0007686)1.63170089
155Hyperglycinuria (HP:0003108)1.63035636
156Hypoplasia of the uterus (HP:0000013)1.62173726
157Progressive inability to walk (HP:0002505)1.62042286
158Tubulointerstitial nephritis (HP:0001970)1.61338344

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.49005329
2STK394.12878218
3MUSK3.24882303
4STK163.06941429
5MST42.98929648
6TNIK2.78410108
7OXSR12.54262164
8PBK2.50332353
9NME12.40660417
10ZAK2.35417316
11CASK2.33715453
12MAP4K22.15569117
13WNK42.14419802
14MAP3K42.14011349
15NUAK12.13552972
16MAPKAPK52.05774055
17NME21.86666652
18VRK11.69955857
19TRIM281.63086597
20PNCK1.61524215
21BMPR1B1.61454070
22MYLK1.58368023
23ACVR1B1.56296411
24BMPR21.56253667
25MKNK21.56130114
26ADRBK21.55296831
27GRK71.54323976
28TAOK31.49341439
29BCR1.47008487
30CDK191.42304130
31BUB11.39662847
32CSNK1G31.39534767
33GRK51.38325061
34MAPK131.37393843
35ARAF1.35540311
36PHKG21.32119337
37PHKG11.32119337
38PDK31.31726814
39PDK41.31726814
40DYRK21.30824555
41BRSK21.30684230
42OBSCN1.30109574
43PKN11.29683047
44INSRR1.29461544
45MAP3K121.25131795
46PAK31.23444334
47PLK41.21519905
48TESK21.17279984
49IRAK11.14961108
50IRAK21.14449099
51CAMK2B1.12709473
52PLK31.11340863
53ERBB31.09973593
54CAMK2D1.09137089
55VRK21.05004462
56EIF2AK31.04916329
57MAPK151.04850437
58LIMK11.03033098
59TLK11.01039272
60MET1.00779568
61STK38L0.93809549
62UHMK10.93487521
63FGR0.93346226
64CSNK1A1L0.92430538
65PRKCG0.91458991
66CSNK1G10.90884062
67MAP2K70.90397985
68NTRK30.90281908
69PRKCQ0.88992643
70EPHB10.87713587
71CAMK2A0.87222155
72DAPK20.84519862
73PDK20.81663199
74CAMK2G0.81454583
75NEK60.80689122
76CSNK1G20.79971426
77EIF2AK10.79252472
78PIM20.78938189
79FGFR20.78688209
80TGFBR10.78606274
81GRK10.78552327
82MKNK10.78379655
83ROCK20.75313294
84WNK30.71803259
85TEC0.70775197
86PASK0.68802679
87PLK20.66080461
88EPHA40.63937166
89DYRK30.63453783
90IRAK40.62333737
91SYK0.60388137
92CLK10.59690655
93PLK10.59580755
94GRK60.58756079
95PRKACA0.58098461
96ADRBK10.58080363
97CDC70.58044091
98MINK10.57150246
99CCNB10.56961464
100RPS6KA50.56842058
101STK240.56094712
102PRKCE0.56090877
103BTK0.55712543
104CAMKK20.54588114
105AKT30.53894812
106TXK0.51687956
107NTRK20.51540978
108PIK3CA0.51492270
109WNK10.51138226
110CDK30.46537563
111FLT30.46195417
112ILK0.46093473
113BCKDK0.44819240
114BRAF0.44560285
115ATR0.44300131
116FES0.43919578
117CSNK1A10.43913557
118TESK10.43535574
119PRKG10.43423353
120SGK20.42625953
121TSSK60.42511598
122ATM0.41876301
123PTK2B0.41518983
124TAF10.41336308
125SRPK10.41324176
126LYN0.41298211
127MAPK120.41232906
128CDK140.40746659
129CSNK1D0.40136932
130NLK0.39370424
131STK30.39325109
132PINK10.39058076
133MAP2K40.38063684
134WEE10.37595336
135DYRK1A0.37433476
136PRKACB0.37202641
137RPS6KA40.36981789
138CAMK10.36610286
139PRPF4B0.36524758
140CSNK2A20.34667965
141ERBB40.34423899
142TIE10.34291929
143LCK0.34107184
144CSNK1E0.33999568
145MARK10.33081745
146AURKA0.32570997
147ABL20.32281030

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.49658244
2Parkinsons disease_Homo sapiens_hsa050124.68733387
3Alzheimers disease_Homo sapiens_hsa050103.58446919
4Protein export_Homo sapiens_hsa030603.52511546
5Huntingtons disease_Homo sapiens_hsa050163.29289782
6Fatty acid elongation_Homo sapiens_hsa000623.29097637
7Ribosome_Homo sapiens_hsa030103.17886998
8Proteasome_Homo sapiens_hsa030503.00030357
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.91537495
10Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.80136235
11Steroid biosynthesis_Homo sapiens_hsa001002.40835054
12Cardiac muscle contraction_Homo sapiens_hsa042602.39553997
13RNA polymerase_Homo sapiens_hsa030202.35272487
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.28510683
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.96368997
16Maturity onset diabetes of the young_Homo sapiens_hsa049501.80299621
17Fanconi anemia pathway_Homo sapiens_hsa034601.77852686
18Nitrogen metabolism_Homo sapiens_hsa009101.75533803
19Ether lipid metabolism_Homo sapiens_hsa005651.69168912
20Collecting duct acid secretion_Homo sapiens_hsa049661.50347341
21Sulfur metabolism_Homo sapiens_hsa009201.48027320
22Selenocompound metabolism_Homo sapiens_hsa004501.46379074
23SNARE interactions in vesicular transport_Homo sapiens_hsa041301.46263816
24Basal transcription factors_Homo sapiens_hsa030221.46144505
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.44174669
26Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.42505316
27Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.31422970
28Propanoate metabolism_Homo sapiens_hsa006401.25556294
29Sphingolipid metabolism_Homo sapiens_hsa006001.21780258
30Histidine metabolism_Homo sapiens_hsa003401.20012433
31Pyruvate metabolism_Homo sapiens_hsa006201.14660447
32Linoleic acid metabolism_Homo sapiens_hsa005911.12873852
33Glutathione metabolism_Homo sapiens_hsa004801.08670955
34Arachidonic acid metabolism_Homo sapiens_hsa005901.07426846
35Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.05541634
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.03770291
37Tryptophan metabolism_Homo sapiens_hsa003801.03170966
38Pyrimidine metabolism_Homo sapiens_hsa002401.03104808
39Non-homologous end-joining_Homo sapiens_hsa034501.02538070
40Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.98149955
41Metabolic pathways_Homo sapiens_hsa011000.94562895
42Serotonergic synapse_Homo sapiens_hsa047260.94476971
43Caffeine metabolism_Homo sapiens_hsa002320.94390730
44Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.90835176
45Purine metabolism_Homo sapiens_hsa002300.90080577
46Vibrio cholerae infection_Homo sapiens_hsa051100.89858029
47alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.89820142
48Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.89387633
49Peroxisome_Homo sapiens_hsa041460.87848260
50One carbon pool by folate_Homo sapiens_hsa006700.87248190
51Insulin secretion_Homo sapiens_hsa049110.85709648
52Fatty acid metabolism_Homo sapiens_hsa012120.85456275
53Primary bile acid biosynthesis_Homo sapiens_hsa001200.84724582
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.83673998
55Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.82623160
56RNA transport_Homo sapiens_hsa030130.78812329
57Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.78802415
58Butanoate metabolism_Homo sapiens_hsa006500.75264200
59Vitamin B6 metabolism_Homo sapiens_hsa007500.73331232
60Phototransduction_Homo sapiens_hsa047440.72164868
61Olfactory transduction_Homo sapiens_hsa047400.68982132
62Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.63125827
63Circadian rhythm_Homo sapiens_hsa047100.62616127
64Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.61869062
65Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.58385378
66Tyrosine metabolism_Homo sapiens_hsa003500.57640635
67Rheumatoid arthritis_Homo sapiens_hsa053230.57466280
68Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.56769967
69Spliceosome_Homo sapiens_hsa030400.56769578
70Chemical carcinogenesis_Homo sapiens_hsa052040.56729104
71Nucleotide excision repair_Homo sapiens_hsa034200.55317730
72Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54052530
73Arginine and proline metabolism_Homo sapiens_hsa003300.52655583
74Amphetamine addiction_Homo sapiens_hsa050310.52649164
75GABAergic synapse_Homo sapiens_hsa047270.52596174
76DNA replication_Homo sapiens_hsa030300.51489995
77Regulation of autophagy_Homo sapiens_hsa041400.50441981
78Glutamatergic synapse_Homo sapiens_hsa047240.49428331
79Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49321003
80Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48946867
81Taste transduction_Homo sapiens_hsa047420.48168403
82Homologous recombination_Homo sapiens_hsa034400.48101992
83Salivary secretion_Homo sapiens_hsa049700.47804780
84Cocaine addiction_Homo sapiens_hsa050300.46561334
85Hedgehog signaling pathway_Homo sapiens_hsa043400.46424370
86Nicotine addiction_Homo sapiens_hsa050330.46196999
87Oocyte meiosis_Homo sapiens_hsa041140.45780971
88Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.45393004
89RNA degradation_Homo sapiens_hsa030180.44395716
90ABC transporters_Homo sapiens_hsa020100.43674827
91Fatty acid degradation_Homo sapiens_hsa000710.43350840
92Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.42123257
93Base excision repair_Homo sapiens_hsa034100.40660221
94Morphine addiction_Homo sapiens_hsa050320.40127977
95Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.39876260
96Folate biosynthesis_Homo sapiens_hsa007900.38412694
97Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.37678062
98Retinol metabolism_Homo sapiens_hsa008300.37597856
99Primary immunodeficiency_Homo sapiens_hsa053400.37404863
100Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.37000442
101Autoimmune thyroid disease_Homo sapiens_hsa053200.34933235
102Mismatch repair_Homo sapiens_hsa034300.34317437
103Mineral absorption_Homo sapiens_hsa049780.33465090
104Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.31185263
105Phenylalanine metabolism_Homo sapiens_hsa003600.26868755
106Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.26393766
107Carbon metabolism_Homo sapiens_hsa012000.24616187
108Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.24405785
109Calcium signaling pathway_Homo sapiens_hsa040200.23057481
110Fatty acid biosynthesis_Homo sapiens_hsa000610.22741724
111Allograft rejection_Homo sapiens_hsa053300.21731048
112Phagosome_Homo sapiens_hsa041450.21417028
113Sulfur relay system_Homo sapiens_hsa041220.21264236
114Long-term depression_Homo sapiens_hsa047300.20748979
115Cysteine and methionine metabolism_Homo sapiens_hsa002700.20702903
116Circadian entrainment_Homo sapiens_hsa047130.20332348
117Renin secretion_Homo sapiens_hsa049240.18805026
118Dopaminergic synapse_Homo sapiens_hsa047280.18269609
119Synaptic vesicle cycle_Homo sapiens_hsa047210.17703619
120beta-Alanine metabolism_Homo sapiens_hsa004100.17460786
121Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.16321446
122Steroid hormone biosynthesis_Homo sapiens_hsa001400.16264857
123Vascular smooth muscle contraction_Homo sapiens_hsa042700.15097093
124Axon guidance_Homo sapiens_hsa043600.15060823
125Gastric acid secretion_Homo sapiens_hsa049710.13874278
126Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.12733797
127Asthma_Homo sapiens_hsa053100.12591096

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