ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	purine nucleobase biosynthetic process (GO:0009113)	5.02203674
2	folic acid metabolic process (GO:0046655)	4.95445700
3	mitotic metaphase plate congression (GO:0007080)	4.80714972
4	folic acid transport (GO:0015884)	4.70732022
5	serine family amino acid catabolic process (GO:0009071)	4.31736372
6	glycine metabolic process (GO:0006544)	4.23802160
7	ribosome assembly (GO:0042255)	4.17469846
8	intestinal epithelial cell development (GO:0060576)	4.12732446
9	ribosome biogenesis (GO:0042254)	4.09476463
10	synaptonemal complex assembly (GO:0007130)	4.05061106
11	nucleobase biosynthetic process (GO:0046112)	4.04272822
12	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	4.02180568
13	fructose metabolic process (GO:0006000)	3.96541486
14	rRNA modification (GO:0000154)	3.88246796
15	7-methylguanosine mRNA capping (GO:0006370)	3.86748510
16	histone-serine phosphorylation (GO:0035404)	3.81957665
17	biotin metabolic process (GO:0006768)	3.79584987
18	lung-associated mesenchyme development (GO:0060484)	3.79410502
19	regulation of spindle organization (GO:0090224)	3.77485719
20	DNA replication checkpoint (GO:0000076)	3.71015015
21	RNA capping (GO:0036260)	3.67854520
22	7-methylguanosine RNA capping (GO:0009452)	3.67854520
23	cysteine metabolic process (GO:0006534)	3.65236099
24	synaptonemal complex organization (GO:0070193)	3.62585066
25	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.61598971
26	serine family amino acid metabolic process (GO:0009069)	3.58408234
27	meiosis I (GO:0007127)	3.56601512
28	positive regulation of chromosome segregation (GO:0051984)	3.55468994
29	metaphase plate congression (GO:0051310)	3.54376626
30	labyrinthine layer development (GO:0060711)	3.51872512
31	histone exchange (GO:0043486)	3.50046883
32	termination of RNA polymerase I transcription (GO:0006363)	3.47888825
33	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	3.45675170
34	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.45029029
35	termination of RNA polymerase III transcription (GO:0006386)	3.45029029
36	G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:0007199	3.40023081
37	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.36945487
38	serine family amino acid biosynthetic process (GO:0009070)	3.36448996
39	transcription elongation from RNA polymerase I promoter (GO:0006362)	3.35884901
40	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	3.35773728
41	male meiosis I (GO:0007141)	3.35173763
42	S-adenosylmethionine metabolic process (GO:0046500)	3.29536063
43	cell wall macromolecule catabolic process (GO:0016998)	3.29297283
44	cell wall macromolecule metabolic process (GO:0044036)	3.29297283
45	L-methionine salvage (GO:0071267)	3.28186937
46	L-methionine biosynthetic process (GO:0071265)	3.28186937
47	amino acid salvage (GO:0043102)	3.28186937
48	pyrimidine-containing compound transmembrane transport (GO:0072531)	3.25198181
49	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	3.23827829
50	transcription from RNA polymerase I promoter (GO:0006360)	3.16427882
51	blastocyst development (GO:0001824)	3.15499662
52	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	3.13747308
53	fusion of sperm to egg plasma membrane (GO:0007342)	3.13033200
54	regulation of mitotic spindle organization (GO:0060236)	3.11458623
55	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.10555538
56	CENP-A containing nucleosome assembly (GO:0034080)	3.06259117
57	vitamin transmembrane transport (GO:0035461)	3.02978622
58	modified amino acid transport (GO:0072337)	3.01376383
59	negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)	3.01296148
60	positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)	3.00990920
61	autophagic vacuole assembly (GO:0000045)	2.99316620
62	positive regulation of ligase activity (GO:0051351)	2.96932668
63	regulation of cellular amino acid metabolic process (GO:0006521)	2.95623516
64	rRNA methylation (GO:0031167)	2.95400056
65	L-serine metabolic process (GO:0006563)	2.95263805
66	sulfur amino acid biosynthetic process (GO:0000097)	2.95056380
67	regulation of chromosome segregation (GO:0051983)	2.93986759
68	protein localization to kinetochore (GO:0034501)	2.91480730
69	transcription from mitochondrial promoter (GO:0006390)	2.89507034
70	ribonucleoprotein complex biogenesis (GO:0022613)	2.88561196
71	transcription initiation from RNA polymerase I promoter (GO:0006361)	2.88132643
72	alditol metabolic process (GO:0019400)	2.87137340
73	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	2.85792495
74	microtubule depolymerization (GO:0007019)	2.84398248
75	cofactor transport (GO:0051181)	2.83849081
76	chromatin remodeling at centromere (GO:0031055)	2.83280629
77	urate metabolic process (GO:0046415)	2.82965752
78	sperm motility (GO:0030317)	2.82927140
79	spindle checkpoint (GO:0031577)	2.82682380
80	single strand break repair (GO:0000012)	2.81732317
81	establishment of chromosome localization (GO:0051303)	2.80964852
82	polyamine biosynthetic process (GO:0006596)	2.80909778
83	pantothenate metabolic process (GO:0015939)	2.80865011
84	piRNA metabolic process (GO:0034587)	2.79320455
85	proteasome assembly (GO:0043248)	2.77589462
86	negative regulation of ligase activity (GO:0051352)	2.76982186
87	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.76982186
88	homocysteine metabolic process (GO:0050667)	2.76175017
89	heme transport (GO:0015886)	2.76111220
90	formation of translation preinitiation complex (GO:0001731)	2.75302130
91	regulation of ubiquitin-protein transferase activity (GO:0051438)	2.74089178
92	CDP-diacylglycerol metabolic process (GO:0046341)	2.73784570
93	sulfur amino acid catabolic process (GO:0000098)	2.73452952
94	positive regulation of viral transcription (GO:0050434)	2.73433185
95	transcription elongation from RNA polymerase II promoter (GO:0006368)	2.73162705
96	regulation of exit from mitosis (GO:0007096)	2.72698257
97	reciprocal meiotic recombination (GO:0007131)	2.71925716
98	reciprocal DNA recombination (GO:0035825)	2.71925716
99	amino sugar catabolic process (GO:0046348)	2.71557614
100	methionine metabolic process (GO:0006555)	2.69898728

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	7.66873556
2	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	4.46255019
3	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	4.20278795
4	CREB1_15753290_ChIP-ChIP_HEK293T_Human	3.43594488
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.27793913
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.11171023
7	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.05938100
8	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.04566276
9	AR_21909140_ChIP-Seq_LNCAP_Human	2.93284390
10	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.92493046
11	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.74684843
12	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	2.74184264
13	EGR1_23403033_ChIP-Seq_LIVER_Mouse	2.61521584
14	KAP1_22055183_ChIP-Seq_ESCs_Mouse	2.53491919
15	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.35244814
16	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.34455642
17	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.30894506
18	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.22774952
19	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.12780556
20	VDR_23849224_ChIP-Seq_CD4+_Human	2.06164711
21	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.04786521
22	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.04732169
23	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.00445515
24	ZNF263_19887448_ChIP-Seq_K562_Human	1.96577572
25	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.96502381
26	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.95877075
27	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.94958179
28	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.93859672
29	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.87264046
30	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.87003754
31	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.82359719
32	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.79972924
33	E2F7_22180533_ChIP-Seq_HELA_Human	1.72181820
34	NACC1_18358816_ChIP-ChIP_MESCs_Mouse	1.70470690
35	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.69154172
36	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.60787099
37	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.60233515
38	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.59312750
39	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.58329195
40	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.58057627
41	GABP_19822575_ChIP-Seq_HepG2_Human	1.57569790
42	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.46888870
43	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.41262030
44	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	1.40392503
45	XRN2_22483619_ChIP-Seq_HELA_Human	1.39860894
46	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.28839056
47	LXR_22158963_ChIP-Seq_LIVER_Mouse	1.28538233
48	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.28265795
49	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.25238065
50	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.24733658
51	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.23739034
52	FOXP3_21729870_ChIP-Seq_TREG_Human	1.22839139
53	SMAD1_18555785_ChIP-Seq_MESCs_Mouse	1.21652808
54	DCP1A_22483619_ChIP-Seq_HELA_Human	1.21578213
55	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.19931164
56	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.19639110
57	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.17780068
58	NANOG_21062744_ChIP-ChIP_HESCs_Human	1.16378099
59	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.16111057
60	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.11656568
61	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	1.10933000
62	HTT_18923047_ChIP-ChIP_STHdh_Human	1.09682827
63	NANOG_18692474_ChIP-Seq_MEFs_Mouse	1.07271841
64	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.06796090
65	KDM5A_27292631_Chip-Seq_BREAST_Human	1.06770422
66	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.06468286
67	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.06384475
68	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.05671328
69	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.04599176
70	NANOG_18358816_ChIP-ChIP_MESCs_Mouse	1.00592217
71	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.00088956
72	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.98994588
73	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.97296502
74	SOX2_18692474_ChIP-Seq_MEFs_Mouse	0.96070335
75	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	0.95183703
76	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.94881655
77	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	0.94657150
78	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.94536969
79	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	0.91348254
80	SOX17_20123909_ChIP-Seq_XEN_Mouse	0.89801424
81	TTF2_22483619_ChIP-Seq_HELA_Human	0.89552099
82	SALL4_18804426_ChIP-ChIP_XEN_Mouse	0.85482952
83	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.85185166
84	E2F1_21310950_ChIP-Seq_MCF-7_Human	0.85129533
85	TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse	0.84864837
86	POU5F1_18692474_ChIP-Seq_MESCs_Mouse	0.84649306
87	ZFX_18555785_ChIP-Seq_MESCs_Mouse	0.80759994
88	KAP1_27257070_Chip-Seq_ESCs_Mouse	0.80301906
89	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.79177719
90	STAT1_17558387_ChIP-Seq_HELA_Human	0.79012408
91	RARB_24833708_ChIP-Seq_LIVER_Mouse	0.78803451
92	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.78750369
93	CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.77746248
94	TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.77580111
95	OCT4_18692474_ChIP-Seq_MEFs_Mouse	0.77394875
96	NANOG_16518401_ChIP-PET_MESCs_Mouse	0.77138673
97	TCF3_18692474_ChIP-Seq_MEFs_Mouse	0.77076360
98	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.76817056
99	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.76198650
100	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.75779748

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003693_abnormal_embryo_hatching	5.61332229
2	MP0003718_maternal_effect	4.12664885
3	MP0009840_abnormal_foam_cell	3.79748450
4	MP0003111_abnormal_nucleus_morphology	3.62556275
5	MP0005360_urolithiasis	3.61413405
6	MP0005085_abnormal_gallbladder_physiolo	3.38498821
7	MP0002139_abnormal_hepatobiliary_system	3.32842387
8	MP0004957_abnormal_blastocyst_morpholog	3.26577899
9	MP0003806_abnormal_nucleotide_metabolis	3.07658344
10	MP0000383_abnormal_hair_follicle	2.94019383
11	MP0005451_abnormal_body_composition	2.93246547
12	MP0005365_abnormal_bile_salt	2.85227731
13	MP0008260_abnormal_autophagy	2.72075757
14	MP0005410_abnormal_fertilization	2.43365177
15	MP0005332_abnormal_amino_acid	2.31932421
16	MP0010678_abnormal_skin_adnexa	2.31866656
17	MP0004019_abnormal_vitamin_homeostasis	2.19373451
18	MP0003077_abnormal_cell_cycle	2.15283055
19	MP0008875_abnormal_xenobiotic_pharmacok	2.14019174
20	MP0003195_calcinosis	2.00559062
21	MP0001929_abnormal_gametogenesis	1.96755459
22	MP0005670_abnormal_white_adipose	1.94250739
23	MP0005408_hypopigmentation	1.93074364
24	MP0010094_abnormal_chromosome_stability	1.92395241
25	MP0004130_abnormal_muscle_cell	1.91735208
26	MP0008057_abnormal_DNA_replication	1.88870043
27	MP0008877_abnormal_DNA_methylation	1.88524556
28	MP0005395_other_phenotype	1.72145981
29	MP0010329_abnormal_lipoprotein_level	1.65219180
30	MP0003656_abnormal_erythrocyte_physiolo	1.61756945
31	MP0000465_gastrointestinal_hemorrhage	1.56736746
32	MP0008058_abnormal_DNA_repair	1.56442570
33	MP0001730_embryonic_growth_arrest	1.55224239
34	MP0002210_abnormal_sex_determination	1.51544781
35	MP0001764_abnormal_homeostasis	1.51069780
36	MP0003698_abnormal_male_reproductive	1.50248551
37	MP0003950_abnormal_plasma_membrane	1.47485430
38	MP0001661_extended_life_span	1.44760674
39	MP0008932_abnormal_embryonic_tissue	1.43335956
40	MP0004185_abnormal_adipocyte_glucose	1.41256701
41	MP0003646_muscle_fatigue	1.39989480
42	MP0003786_premature_aging	1.36001068
43	MP0001145_abnormal_male_reproductive	1.33837849
44	MP0010307_abnormal_tumor_latency	1.31704795
45	MP0003186_abnormal_redox_activity	1.31660319
46	MP0000653_abnormal_sex_gland	1.28725679
47	MP0003315_abnormal_perineum_morphology	1.28535382
48	MP0006035_abnormal_mitochondrial_morpho	1.24785888
49	MP0000609_abnormal_liver_physiology	1.21215517
50	MP0003828_pulmonary_edema	1.20264123
51	MP0001756_abnormal_urination	1.19224723
52	MP0002118_abnormal_lipid_homeostasis	1.16927918
53	MP0002161_abnormal_fertility/fecundity	1.13198547
54	MP0005319_abnormal_enzyme/_coenzyme	1.09207794
55	MP0008007_abnormal_cellular_replicative	1.06045903
56	MP0000350_abnormal_cell_proliferation	1.05331076
57	MP0001666_abnormal_nutrient_absorption	1.02685849
58	MP0001697_abnormal_embryo_size	1.02056908
59	MP0005666_abnormal_adipose_tissue	1.01733649
60	MP0005380_embryogenesis_phenotype	1.01030372
61	MP0001672_abnormal_embryogenesis/_devel	1.01030372
62	MP0005389_reproductive_system_phenotype	1.00666723
63	MP0003699_abnormal_female_reproductive	0.98038724
64	MP0009643_abnormal_urine_homeostasis	0.97997629
65	MP0003724_increased_susceptibility_to	0.97464709
66	MP0000647_abnormal_sebaceous_gland	0.96668373
67	MP0006036_abnormal_mitochondrial_physio	0.94739487
68	MP0002080_prenatal_lethality	0.89999080
69	MP0001542_abnormal_bone_strength	0.85968923
70	MP0000358_abnormal_cell_content/	0.84412783
71	MP0003221_abnormal_cardiomyocyte_apopto	0.84306001
72	MP0000598_abnormal_liver_morphology	0.83582725
73	MP0004043_abnormal_pH_regulation	0.81806636
74	MP0003938_abnormal_ear_development	0.81346578
75	MP0002086_abnormal_extraembryonic_tissu	0.81250105
76	MP0003123_paternal_imprinting	0.79013019
77	MP0001545_abnormal_hematopoietic_system	0.76400926
78	MP0005397_hematopoietic_system_phenotyp	0.76400926
79	MP0001119_abnormal_female_reproductive	0.72599883
80	MP0002088_abnormal_embryonic_growth/wei	0.72415540
81	MP0006292_abnormal_olfactory_placode	0.72320587
82	MP0002102_abnormal_ear_morphology	0.72132730
83	MP0005636_abnormal_mineral_homeostasis	0.71534792
84	MP0004084_abnormal_cardiac_muscle	0.69173333
85	MP0003984_embryonic_growth_retardation	0.68976131
86	MP0005084_abnormal_gallbladder_morpholo	0.65655155
87	MP0003937_abnormal_limbs/digits/tail_de	0.65116454
88	MP0009697_abnormal_copulation	0.64824721
89	MP0006138_congestive_heart_failure	0.64430924
90	MP0002160_abnormal_reproductive_system	0.64400504
91	MP0005377_hearing/vestibular/ear_phenot	0.63874841
92	MP0003878_abnormal_ear_physiology	0.63874841
93	MP0005376_homeostasis/metabolism_phenot	0.63831658
94	MP0003941_abnormal_skin_development	0.61867601
95	MP0002653_abnormal_ependyma_morphology	0.61598702
96	MP0002085_abnormal_embryonic_tissue	0.61565213
97	MP0003329_amyloid_beta_deposits	0.58612819
98	MP0003252_abnormal_bile_duct	0.57716695
99	MP0002084_abnormal_developmental_patter	0.57158494
100	MP0000313_abnormal_cell_death	0.54720773

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hyperglycinuria (HP:0003108)	7.11621099
2	Abnormality of serine family amino acid metabolism (HP:0010894)	6.06574309
3	Abnormality of glycine metabolism (HP:0010895)	6.06574309
4	Hyperglycinemia (HP:0002154)	5.75236463
5	Spontaneous abortion (HP:0005268)	4.40447561
6	Hyperlipoproteinemia (HP:0010980)	4.17293319
7	Abnormal spermatogenesis (HP:0008669)	4.12971407
8	Onycholysis (HP:0001806)	4.05246984
9	Birth length less than 3rd percentile (HP:0003561)	4.03883835
10	Breast hypoplasia (HP:0003187)	3.91557630
11	Gout (HP:0001997)	3.89027456
12	Abnormality of serum amino acid levels (HP:0003112)	3.85473861
13	Abnormality of the heme biosynthetic pathway (HP:0010472)	3.35804022
14	Impulsivity (HP:0100710)	3.30086678
15	Abnormality of aromatic amino acid family metabolism (HP:0004338)	3.24833126
16	Cerebral hypomyelination (HP:0006808)	3.24408538
17	Hyperammonemia (HP:0001987)	3.21632734
18	Xanthomatosis (HP:0000991)	3.15254838
19	Nausea (HP:0002018)	3.03642957
20	Carpal bone hypoplasia (HP:0001498)	2.94343340
21	Seborrheic dermatitis (HP:0001051)	2.91193634
22	Azoospermia (HP:0000027)	2.87973367
23	Ureteral duplication (HP:0000073)	2.87470001
24	Prolonged neonatal jaundice (HP:0006579)	2.82593566
25	Glucose intolerance (HP:0000833)	2.80250344
26	Ileus (HP:0002595)	2.76318500
27	Hypobetalipoproteinemia (HP:0003563)	2.74578399
28	Rough bone trabeculation (HP:0100670)	2.69538667
29	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.69346595
30	Hypoalphalipoproteinemia (HP:0003233)	2.63503556
31	Secondary amenorrhea (HP:0000869)	2.63058143
32	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	2.62819422
33	Lethargy (HP:0001254)	2.62731704
34	Abnormality of monocarboxylic acid metabolism (HP:0010996)	2.59764059
35	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.59181113
36	Absent/shortened dynein arms (HP:0200106)	2.59181113
37	Patellar aplasia (HP:0006443)	2.58138826
38	Abnormality of the umbilical cord (HP:0010881)	2.56773041
39	Hypolipoproteinemia (HP:0010981)	2.56485869
40	Dicarboxylic aciduria (HP:0003215)	2.55334036
41	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.55334036
42	Hyperglycemia (HP:0003074)	2.52895172
43	Aplasia/Hypoplasia of the patella (HP:0006498)	2.52813748
44	Pelvic girdle muscle weakness (HP:0003749)	2.49408861
45	CNS hypomyelination (HP:0003429)	2.47183528
46	Chronic bronchitis (HP:0004469)	2.44673336
47	Premature ovarian failure (HP:0008209)	2.42029230
48	Death in infancy (HP:0001522)	2.37470499
49	Prolonged partial thromboplastin time (HP:0003645)	2.36291675
50	Capillary hemangiomas (HP:0005306)	2.33601918
51	Shoulder girdle muscle weakness (HP:0003547)	2.31154517
52	Increased purine levels (HP:0004368)	2.30761132
53	Hyperuricemia (HP:0002149)	2.30761132
54	Multiple enchondromatosis (HP:0005701)	2.30745255
55	Abnormality of alanine metabolism (HP:0010916)	2.27780335
56	Hyperalaninemia (HP:0003348)	2.27780335
57	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.27780335
58	Abnormal delivery (HP:0001787)	2.27655487
59	Spastic paraparesis (HP:0002313)	2.27522119
60	Deep venous thrombosis (HP:0002625)	2.27413524
61	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	2.26773899
62	Entropion (HP:0000621)	2.25872051
63	Atrioventricular block (HP:0001678)	2.25519897
64	Megaloblastic anemia (HP:0001889)	2.21337025
65	Tetraplegia (HP:0002445)	2.15958988
66	Male infertility (HP:0003251)	2.14610744
67	Ketosis (HP:0001946)	2.10952198
68	Intrahepatic cholestasis (HP:0001406)	2.10581110
69	Oral leukoplakia (HP:0002745)	2.08875849
70	Ketoacidosis (HP:0001993)	2.07340687
71	Abnormality of the hip-girdle musculature (HP:0001445)	2.05322371
72	Abnormality of the musculature of the pelvis (HP:0001469)	2.05322371
73	Proximal tubulopathy (HP:0000114)	2.05181596
74	Pancreatic fibrosis (HP:0100732)	2.01435447
75	Conjunctival telangiectasia (HP:0000524)	2.00868029
76	Abnormal glucose tolerance (HP:0001952)	2.00281886
77	Anorexia (HP:0002039)	1.99445559
78	Oligodactyly (hands) (HP:0001180)	1.98922716
79	Polycythemia (HP:0001901)	1.98677156
80	Irritability (HP:0000737)	1.98020019
81	Abnormality of fatty-acid metabolism (HP:0004359)	1.96056188
82	Epidermoid cyst (HP:0200040)	1.95205072
83	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.93841659
84	Abnormality of the labia minora (HP:0012880)	1.92344358
85	Bundle branch block (HP:0011710)	1.92216782
86	Abnormal trabecular bone morphology (HP:0100671)	1.91687080
87	Abnormality of purine metabolism (HP:0004352)	1.90580506
88	Difficulty climbing stairs (HP:0003551)	1.89544026
89	Delusions (HP:0000746)	1.89137219
90	Progressive muscle weakness (HP:0003323)	1.86873574
91	Absent radius (HP:0003974)	1.86347873
92	Brittle hair (HP:0002299)	1.85555146
93	Insulin-resistant diabetes mellitus (HP:0000831)	1.84928130
94	Complement deficiency (HP:0004431)	1.84576907
95	CNS demyelination (HP:0007305)	1.83596496
96	Aplasia/Hypoplasia involving the musculature (HP:0001460)	1.82815849
97	Abnormality of sulfur amino acid metabolism (HP:0004339)	1.81171918
98	Gonadotropin excess (HP:0000837)	1.80221607
99	Abnormality of nucleobase metabolism (HP:0010932)	1.80167878
100	Microvesicular hepatic steatosis (HP:0001414)	1.79443021

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PDK4	4.78029124
2	PDK3	4.78029124
3	WEE1	4.66311992
4	BUB1	4.13341626
5	EPHA2	3.33425620
6	PDK2	3.30112724
7	EIF2AK1	3.15654739
8	NEK1	2.92996123
9	NME2	2.45196997
10	PLK4	2.36519704
11	PNCK	2.21184628
12	NEK2	2.16663081
13	TTK	2.12462924
14	ARAF	2.12186242
15	BRSK2	1.99536407
16	SRPK1	1.84800415
17	TSSK6	1.71250860
18	PLK1	1.70071242
19	STK16	1.69517450
20	ZAK	1.64226000
21	LATS2	1.63793079
22	PLK3	1.63198613
23	AKT3	1.59895183
24	DYRK3	1.57302744
25	BRAF	1.47038228
26	PINK1	1.37987114
27	CHEK2	1.36370560
28	CCNB1	1.32750011
29	STK38L	1.29383751
30	MAP3K9	1.24287666
31	CDK8	1.24013530
32	CDC7	1.16183099
33	EIF2AK3	1.15915327
34	AURKB	1.15649761
35	BRSK1	1.11967322
36	IRAK3	1.05218039
37	MKNK2	1.01859300
38	MET	0.98934406
39	AURKA	0.98403146
40	NME1	0.95155696
41	RPS6KB2	0.92753461
42	MAPK11	0.88600141
43	MARK3	0.82977975
44	STK3	0.77628131
45	DYRK2	0.75510003
46	RAF1	0.72529364
47	TIE1	0.71216664
48	TEC	0.70709927
49	ACVR1B	0.70294610
50	CDK4	0.67043437
51	MKNK1	0.65200886
52	CDK7	0.62742076
53	BCKDK	0.62492119
54	MST4	0.59921912
55	ABL2	0.54869098
56	CSNK1E	0.54119013
57	PDK1	0.53395712
58	FGFR4	0.50526319
59	PAK1	0.49904648
60	CDK3	0.49803690
61	MAP3K8	0.49157456
62	CHEK1	0.49033709
63	MAPKAPK3	0.49030594
64	CSNK2A1	0.48027583
65	LATS1	0.43875701
66	CSNK1G3	0.43333721
67	PDPK1	0.42975190
68	CDK2	0.42531998
69	CSNK1G2	0.42502978
70	ERBB2	0.42269059
71	STK38	0.41077816
72	CSF1R	0.39258213
73	MELK	0.38083200
74	CSNK1G1	0.37573972
75	MAP3K13	0.36473975
76	ALK	0.36452292
77	PRKCI	0.34602981
78	CSNK2A2	0.34491257
79	IRAK1	0.33907766
80	KSR2	0.31897624
81	CDK1	0.31773415
82	PRKCG	0.31460685
83	VRK1	0.30884730
84	CAMK2G	0.30847474
85	MOS	0.28942960
86	PRKAA1	0.28566485
87	EIF2AK2	0.28551222
88	CAMKK2	0.28474337
89	KDR	0.27497872
90	IRAK2	0.26458708
91	ATR	0.25273534
92	RPS6KA5	0.25060850
93	PIM2	0.23950671
94	PRKCZ	0.22318258
95	DAPK1	0.19755076
96	ATM	0.19281631
97	NUAK1	0.17258318
98	FES	0.16677714
99	TESK2	0.16472187
100	MAP2K2	0.15847281

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Vitamin B6 metabolism_Homo sapiens_hsa00750	5.67355489
2	RNA polymerase_Homo sapiens_hsa03020	3.35230151
3	Proteasome_Homo sapiens_hsa03050	3.16107154
4	Regulation of autophagy_Homo sapiens_hsa04140	2.86466814
5	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.79411880
6	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.72159014
7	Folate biosynthesis_Homo sapiens_hsa00790	2.33570025
8	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.31818469
9	RNA transport_Homo sapiens_hsa03013	2.20111421
10	Pyrimidine metabolism_Homo sapiens_hsa00240	1.99193214
11	Pentose phosphate pathway_Homo sapiens_hsa00030	1.95537396
12	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.84891460
13	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.84478253
14	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.80877648
15	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.79705959
16	Basal transcription factors_Homo sapiens_hsa03022	1.74761191
17	Cell cycle_Homo sapiens_hsa04110	1.69190702
18	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.57848718
19	Nitrogen metabolism_Homo sapiens_hsa00910	1.57431107
20	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.55854479
21	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.55472828
22	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.51331519
23	Ribosome_Homo sapiens_hsa03010	1.45969728
24	Arginine biosynthesis_Homo sapiens_hsa00220	1.44969216
25	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.40972740
26	Caffeine metabolism_Homo sapiens_hsa00232	1.40527652
27	PPAR signaling pathway_Homo sapiens_hsa03320	1.39504144
28	Selenocompound metabolism_Homo sapiens_hsa00450	1.39258701
29	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.36907085
30	Nucleotide excision repair_Homo sapiens_hsa03420	1.34664341
31	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.30936703
32	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.30532742
33	Carbon metabolism_Homo sapiens_hsa01200	1.26812229
34	Spliceosome_Homo sapiens_hsa03040	1.25573289
35	beta-Alanine metabolism_Homo sapiens_hsa00410	1.24877684
36	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.24324479
37	Propanoate metabolism_Homo sapiens_hsa00640	1.23897662
38	Glutathione metabolism_Homo sapiens_hsa00480	1.22967115
39	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.21877159
40	Peroxisome_Homo sapiens_hsa04146	1.21816178
41	Purine metabolism_Homo sapiens_hsa00230	1.20911737
42	Butanoate metabolism_Homo sapiens_hsa00650	1.16009174
43	Oocyte meiosis_Homo sapiens_hsa04114	1.14085359
44	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.11083570
45	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.08979436
46	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.07784026
47	p53 signaling pathway_Homo sapiens_hsa04115	1.00540732
48	Retinol metabolism_Homo sapiens_hsa00830	0.99405840
49	Chemical carcinogenesis_Homo sapiens_hsa05204	0.99302748
50	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.97437098
51	Fatty acid degradation_Homo sapiens_hsa00071	0.97168110
52	Homologous recombination_Homo sapiens_hsa03440	0.96226146
53	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.95665052
54	DNA replication_Homo sapiens_hsa03030	0.95460442
55	Arginine and proline metabolism_Homo sapiens_hsa00330	0.93679671
56	Base excision repair_Homo sapiens_hsa03410	0.92379786
57	Sulfur relay system_Homo sapiens_hsa04122	0.89282573
58	Histidine metabolism_Homo sapiens_hsa00340	0.88490101
59	Tryptophan metabolism_Homo sapiens_hsa00380	0.87159514
60	Glycerolipid metabolism_Homo sapiens_hsa00561	0.84003199
61	Complement and coagulation cascades_Homo sapiens_hsa04610	0.83696560
62	mRNA surveillance pathway_Homo sapiens_hsa03015	0.82145358
63	Linoleic acid metabolism_Homo sapiens_hsa00591	0.81484588
64	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.80276048
65	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.77952950
66	Metabolic pathways_Homo sapiens_hsa01100	0.75882224
67	Fatty acid elongation_Homo sapiens_hsa00062	0.75488963
68	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.74929232
69	Fat digestion and absorption_Homo sapiens_hsa04975	0.73685980
70	Fatty acid metabolism_Homo sapiens_hsa01212	0.72571619
71	Phenylalanine metabolism_Homo sapiens_hsa00360	0.72487059
72	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.71714250
73	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.66175691
74	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.64785978
75	Pyruvate metabolism_Homo sapiens_hsa00620	0.64120706
76	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.60908218
77	Mismatch repair_Homo sapiens_hsa03430	0.59590162
78	Fanconi anemia pathway_Homo sapiens_hsa03460	0.59307692
79	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.57105586
80	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.56386079
81	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.56015481
82	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.55530167
83	Huntingtons disease_Homo sapiens_hsa05016	0.53610617
84	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.52254019
85	Bile secretion_Homo sapiens_hsa04976	0.50173524
86	Sulfur metabolism_Homo sapiens_hsa00920	0.49216665
87	RNA degradation_Homo sapiens_hsa03018	0.48763822
88	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.47928256
89	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.46661808
90	Tyrosine metabolism_Homo sapiens_hsa00350	0.39794226
91	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.37337813
92	Circadian rhythm_Homo sapiens_hsa04710	0.36549960
93	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.31155233
94	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.28324806
95	Ether lipid metabolism_Homo sapiens_hsa00565	0.27915201
96	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.27439718
97	One carbon pool by folate_Homo sapiens_hsa00670	0.26949886
98	Mineral absorption_Homo sapiens_hsa04978	0.26308590
99	Prion diseases_Homo sapiens_hsa05020	0.24743320
100	ABC transporters_Homo sapiens_hsa02010	0.19550410

SMIM9

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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