SMKR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm capacitation (GO:0048240)9.72988775
2fusion of sperm to egg plasma membrane (GO:0007342)9.40550281
3chromosome condensation (GO:0030261)8.55235923
4spermatid development (GO:0007286)8.48513575
5DNA packaging (GO:0006323)8.45542647
6single strand break repair (GO:0000012)8.12781454
7spermatid nucleus differentiation (GO:0007289)7.97379305
8multicellular organism reproduction (GO:0032504)7.77058353
9microtubule depolymerization (GO:0007019)7.35784342
10axonemal dynein complex assembly (GO:0070286)7.28260706
11sperm-egg recognition (GO:0035036)7.28030220
12plasma membrane fusion (GO:0045026)7.16594261
13reproduction (GO:0000003)7.03477250
14protein polyglutamylation (GO:0018095)6.89740320
15binding of sperm to zona pellucida (GO:0007339)6.74151905
16response to pheromone (GO:0019236)6.72555856
17rRNA methylation (GO:0031167)6.58039008
18microtubule severing (GO:0051013)6.52116925
19negative regulation of inclusion body assembly (GO:0090084)6.51580717
20calcium ion-dependent exocytosis (GO:0017156)6.45286955
21phosphatidylethanolamine biosynthetic process (GO:0006646)6.33997724
22microtubule polymerization or depolymerization (GO:0031109)6.10063631
23sexual reproduction (GO:0019953)6.04880323
24spermatogenesis (GO:0007283)6.03702732
25male gamete generation (GO:0048232)6.01559537
26cell-cell recognition (GO:0009988)5.94169950
27regulation of cilium movement (GO:0003352)5.89437128
28phosphatidylethanolamine metabolic process (GO:0046337)5.86653542
29cilium or flagellum-dependent cell motility (GO:0001539)5.84000062
30centriole replication (GO:0007099)5.83705033
31protein targeting to Golgi (GO:0000042)5.67892389
32rRNA modification (GO:0000154)5.64924990
33gamete generation (GO:0007276)5.56879158
34epithelial cilium movement (GO:0003351)5.39052074
35establishment of protein localization to Golgi (GO:0072600)5.38196004
36motile cilium assembly (GO:0044458)5.35805632
37retrograde transport, vesicle recycling within Golgi (GO:0000301)5.32021812
38single fertilization (GO:0007338)5.15845537
39centriole assembly (GO:0098534)5.14501848
40cellular ketone body metabolic process (GO:0046950)5.06409185
41germ cell development (GO:0007281)5.02957798
42RNA destabilization (GO:0050779)4.98897275
43cilium movement (GO:0003341)4.88053412
44regulation of inclusion body assembly (GO:0090083)4.74849302
45cellular process involved in reproduction in multicellular organism (GO:0022412)4.69035335
46nucleus organization (GO:0006997)4.67530496
47piRNA metabolic process (GO:0034587)4.66209867
48regulation of microtubule-based movement (GO:0060632)4.59725726
49positive regulation of Rab GTPase activity (GO:0032851)4.58069936
50regulation of Rab GTPase activity (GO:0032313)4.58069936
51fertilization (GO:0009566)4.57173828
52multicellular organismal reproductive process (GO:0048609)4.47105490
53ketone body metabolic process (GO:1902224)4.42667574
54response to acidic pH (GO:0010447)4.34448191
55regulation of female gonad development (GO:2000194)4.32567253
56regulation of transcription involved in cell fate commitment (GO:0060850)4.28895819
57DNA methylation involved in gamete generation (GO:0043046)4.21904411
58protein localization to Golgi apparatus (GO:0034067)4.07030376
59male meiosis I (GO:0007141)4.06428902
60polyamine biosynthetic process (GO:0006596)3.95677370
61organic cation transport (GO:0015695)3.83002145
62cerebral cortex neuron differentiation (GO:0021895)3.80475255
63cell wall macromolecule catabolic process (GO:0016998)3.79254072
64peptidyl-threonine dephosphorylation (GO:0035970)3.78534067
65cellular response to pH (GO:0071467)3.76695374
66cell wall macromolecule metabolic process (GO:0044036)3.75769186
67regulation of centriole replication (GO:0046599)3.74207883
68chromatin silencing (GO:0006342)3.71522955
69epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.68170897
70histone H3-K9 demethylation (GO:0033169)3.53649481
71regulation of meiosis I (GO:0060631)3.44388614
72meiotic cell cycle (GO:0051321)3.36349231
73multicellular organismal movement (GO:0050879)3.33237488
74musculoskeletal movement (GO:0050881)3.33237488
75negative regulation of histone methylation (GO:0031061)3.27799400
76male meiosis (GO:0007140)3.24013859
77seminiferous tubule development (GO:0072520)3.19379911
78regulation of interleukin-13 production (GO:0032656)3.18543796
79mitochondrial fission (GO:0000266)3.17158232
80membrane protein intracellular domain proteolysis (GO:0031293)3.15334686
81multicellular organismal development (GO:0007275)3.13464117
82meiosis I (GO:0007127)3.11116358
83protein-DNA complex disassembly (GO:0032986)3.09130475
84nucleosome disassembly (GO:0006337)3.09130475
85coenzyme catabolic process (GO:0009109)3.04098403
86histone exchange (GO:0043486)2.93493624
87chaperone-mediated protein complex assembly (GO:0051131)2.91569404
88homeostasis of number of cells within a tissue (GO:0048873)2.91195262
89vesicle transport along microtubule (GO:0047496)2.87378151
90genitalia morphogenesis (GO:0035112)2.86597420
91oocyte development (GO:0048599)2.86379950
92cranial nerve morphogenesis (GO:0021602)2.84927053
93ventricular system development (GO:0021591)2.84830075
94microtubule nucleation (GO:0007020)2.83021463
95cell recognition (GO:0008037)2.82756665
96Golgi to endosome transport (GO:0006895)2.80879383
97protein depolymerization (GO:0051261)2.74823791
98regulation of histone H3-K9 methylation (GO:0051570)2.71199259
99sperm motility (GO:0030317)11.4863061
100acrosome reaction (GO:0007340)11.2075123

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.19592101
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.12038720
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.15956555
4MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.00040478
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.88058707
6POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.36509553
7TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.36509553
8NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.19993798
9CTBP2_25329375_ChIP-Seq_LNCAP_Human2.11881611
10IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.09767567
11CBP_20019798_ChIP-Seq_JUKART_Human2.09767567
12CTBP1_25329375_ChIP-Seq_LNCAP_Human2.05017828
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.02330722
14DROSHA_22980978_ChIP-Seq_HELA_Human1.98970706
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.90884126
16ELF1_20517297_ChIP-Seq_JURKAT_Human1.86383811
17NANOG_20526341_ChIP-Seq_ESCs_Human1.85976397
18VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.83230602
19ERA_21632823_ChIP-Seq_H3396_Human1.75533725
20RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.71001176
21RAC3_21632823_ChIP-Seq_H3396_Human1.70386741
22WDR5_24793694_ChIP-Seq_LNCAP_Human1.68956459
23CTCF_27219007_Chip-Seq_Bcells_Human1.68721906
24EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.67925260
25DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.65780261
26BCL6_27268052_Chip-Seq_Bcells_Human1.64422905
27ER_23166858_ChIP-Seq_MCF-7_Human1.59438052
28FUS_26573619_Chip-Seq_HEK293_Human1.58978864
29EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.58705860
30TDRD3_21172665_ChIP-Seq_MCF-7_Human1.58463731
31AR_25329375_ChIP-Seq_VCAP_Human1.57566876
32YY1_22570637_ChIP-Seq_MALME-3M_Human1.57501285
33SMC4_20622854_ChIP-Seq_HELA_Human1.56724666
34P68_20966046_ChIP-Seq_HELA_Human1.56526649
35UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.55610792
36BCOR_27268052_Chip-Seq_Bcells_Human1.55428033
37PHF8_20622854_ChIP-Seq_HELA_Human1.52785602
38TAF2_19829295_ChIP-Seq_ESCs_Human1.52242121
39EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.51706496
40CTCF_20526341_ChIP-Seq_ESCs_Human1.50407019
41E2F1_20622854_ChIP-Seq_HELA_Human1.50339248
42EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.45540173
43STAT6_21828071_ChIP-Seq_BEAS2B_Human1.45256912
44AUTS2_25519132_ChIP-Seq_293T-REX_Human1.44829758
45SMAD4_21741376_ChIP-Seq_EPCs_Human1.44543588
46ARNT_22903824_ChIP-Seq_MCF-7_Human1.43039439
47ERG_20517297_ChIP-Seq_VCAP_Human1.42470617
48MYC_19829295_ChIP-Seq_ESCs_Human1.40365016
49OCT4_20526341_ChIP-Seq_ESCs_Human1.39866101
50RUNX1_26923725_Chip-Seq_HPCs_Mouse1.39371901
51TP63_22573176_ChIP-Seq_HFKS_Human1.37351552
52SUZ12_27294783_Chip-Seq_ESCs_Mouse1.36239155
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35564184
54P300_27268052_Chip-Seq_Bcells_Human1.32514477
55SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.31058018
56P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.30242138
57EZH2_27294783_Chip-Seq_ESCs_Mouse1.29124097
58GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27724430
59TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27718263
60RBPJ_21746931_ChIP-Seq_IB4_Human1.27046863
61KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.26302337
62SMAD3_21741376_ChIP-Seq_ESCs_Human1.23380117
63BMI1_23680149_ChIP-Seq_NPCS_Mouse1.23315054
64REST_21632747_ChIP-Seq_MESCs_Mouse1.22228842
65PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.22207657
66CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.21820385
67ETV1_20927104_ChIP-Seq_GIST48_Human1.19280320
68CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.18323110
69SOX2_22085726_ChIP-Seq_NPCs_Mouse1.17485269
70P53_21459846_ChIP-Seq_SAOS-2_Human1.17131178
71ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.16957745
72HNFA_21074721_ChIP-Seq_CACO-2_Human1.16683355
73CBX2_22325352_ChIP-Seq_293T-Rex_Human1.16538833
74SMAD4_21799915_ChIP-Seq_A2780_Human1.15699937
75ETV2_25802403_ChIP-Seq_MESCs_Mouse1.15158899
76SMRT_27268052_Chip-Seq_Bcells_Human1.14345081
77TAF15_26573619_Chip-Seq_HEK293_Human1.14132801
78P300_19829295_ChIP-Seq_ESCs_Human1.13779314
79CEBPB_22108803_ChIP-Seq_LS180_Human1.12078390
80TBL1_22424771_ChIP-Seq_293T_Human1.11995144
81SMAD3_21741376_ChIP-Seq_EPCs_Human1.11780136
82PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.11741301
83LXR_22292898_ChIP-Seq_THP-1_Human1.11098890
84GATA3_21878914_ChIP-Seq_MCF-7_Human1.10658810
85NFYB_21822215_ChIP-Seq_K562_Human1.09871616
86RUNX2_22187159_ChIP-Seq_PCA_Human1.09115915
87TP53_18474530_ChIP-ChIP_U2OS_Human1.06371741
88ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.05918886
89OCT4_19829295_ChIP-Seq_ESCs_Human1.05093757
90STAT3_23295773_ChIP-Seq_U87_Human1.04526016
91SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01737183
92PHF8_20622853_ChIP-Seq_HELA_Human1.00962781
93TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00829841
94OCT1_27270436_Chip-Seq_PROSTATE_Human0.99766058
95TP63_19390658_ChIP-ChIP_HaCaT_Human0.99515516
96CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.99499398
97KLF4_19829295_ChIP-Seq_ESCs_Human0.99336645
98TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97546723
99PRDM14_20953172_ChIP-Seq_ESCs_Human0.97295971
100GATA6_21074721_ChIP-Seq_CACO-2_Human0.97054605

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive4.52718033
2MP0001929_abnormal_gametogenesis4.20585158
3MP0005670_abnormal_white_adipose4.06089257
4MP0003878_abnormal_ear_physiology4.05542373
5MP0005377_hearing/vestibular/ear_phenot4.05542373
6MP0003718_maternal_effect3.70741467
7MP0001348_abnormal_lacrimal_gland3.05477204
8MP0002161_abnormal_fertility/fecundity2.79069704
9MP0002210_abnormal_sex_determination2.48937264
10MP0000678_abnormal_parathyroid_gland2.44430901
11MP0008877_abnormal_DNA_methylation2.33393116
12MP0005423_abnormal_somatic_nervous2.18281477
13MP0002234_abnormal_pharynx_morphology2.08227058
14MP0002822_catalepsy2.04049219
15MP0005410_abnormal_fertilization11.3132242
16MP0000653_abnormal_sex_gland1.86375764
17MP0001145_abnormal_male_reproductive1.85259310
18MP0002735_abnormal_chemical_nociception1.83572645
19MP0003879_abnormal_hair_cell1.76602541
20MP0004859_abnormal_synaptic_plasticity1.63769809
21MP0006292_abnormal_olfactory_placode1.60009664
22MP0003646_muscle_fatigue1.56889751
23MP0005395_other_phenotype1.56538558
24MP0001486_abnormal_startle_reflex1.51315621
25MP0002132_abnormal_respiratory_system1.47738893
26MP0002249_abnormal_larynx_morphology1.36812117
27MP0001968_abnormal_touch/_nociception1.36717614
28MP0002138_abnormal_hepatobiliary_system1.21870189
29MP0005451_abnormal_body_composition1.21277027
30MP0005310_abnormal_salivary_gland1.18016580
31MP0003011_delayed_dark_adaptation1.17352779
32MP0001485_abnormal_pinna_reflex1.17084743
33MP0002272_abnormal_nervous_system1.16355329
34MP0003880_abnormal_central_pattern1.13870245
35MP0001765_abnormal_ion_homeostasis1.12114504
36MP0008789_abnormal_olfactory_epithelium1.09662448
37MP0004742_abnormal_vestibular_system1.09244778
38MP0005551_abnormal_eye_electrophysiolog1.08639351
39MP0001984_abnormal_olfaction1.08231250
40MP0001963_abnormal_hearing_physiology1.06450419
41MP0009745_abnormal_behavioral_response1.05711630
42MP0002734_abnormal_mechanical_nocicepti1.05299500
43MP0000534_abnormal_ureter_morphology1.03167807
44MP0005379_endocrine/exocrine_gland_phen1.02649582
45MP0001905_abnormal_dopamine_level1.02317252
46MP0003699_abnormal_female_reproductive1.01644679
47MP0002067_abnormal_sensory_capabilities0.97326534
48MP0002557_abnormal_social/conspecific_i0.93556796
49MP0003077_abnormal_cell_cycle0.92805457
50MP0002572_abnormal_emotion/affect_behav0.92645507
51MP0000955_abnormal_spinal_cord0.92292772
52MP0002282_abnormal_trachea_morphology0.92275141
53MP0002127_abnormal_cardiovascular_syste0.91206609
54MP0005499_abnormal_olfactory_system0.91145472
55MP0005394_taste/olfaction_phenotype0.91145472
56MP0002229_neurodegeneration0.91123857
57MP0008569_lethality_at_weaning0.90978978
58MP0000026_abnormal_inner_ear0.90097174
59MP0003635_abnormal_synaptic_transmissio0.89566793
60MP0002160_abnormal_reproductive_system0.85214304
61MP0000566_synostosis0.83775298
62MP0005647_abnormal_sex_gland0.74723490
63MP0005248_abnormal_Harderian_gland0.74216007
64MP0000049_abnormal_middle_ear0.72693843
65MP0005666_abnormal_adipose_tissue0.71791212
66MP0002733_abnormal_thermal_nociception0.71060075
67MP0001440_abnormal_grooming_behavior0.70639053
68MP0004233_abnormal_muscle_weight0.70502503
69MP0009053_abnormal_anal_canal0.68579143
70MP0009046_muscle_twitch0.66024022
71MP0001970_abnormal_pain_threshold0.63810141
72MP0009697_abnormal_copulation0.63760000
73MP0009115_abnormal_fat_cell0.63662254
74MP0000681_abnormal_thyroid_gland0.63160000
75MP0001666_abnormal_nutrient_absorption0.58337567
76MP0002063_abnormal_learning/memory/cond0.57881433
77MP0003119_abnormal_digestive_system0.57838182
78MP0002064_seizures0.57270968
79MP0006276_abnormal_autonomic_nervous0.56507021
80MP0003693_abnormal_embryo_hatching0.54679166
81MP0002653_abnormal_ependyma_morphology0.54342383
82MP0005636_abnormal_mineral_homeostasis0.54154844
83MP0008995_early_reproductive_senescence0.52666893
84MP0004270_analgesia0.50854357
85MP0001119_abnormal_female_reproductive0.50275458
86MP0004085_abnormal_heartbeat0.49960613
87MP0005375_adipose_tissue_phenotype0.49023165
88MP0005253_abnormal_eye_physiology0.48415724
89MP0003936_abnormal_reproductive_system0.46499369
90MP0005389_reproductive_system_phenotype0.46440193
91MP0003631_nervous_system_phenotype0.45268525
92MP0002882_abnormal_neuron_morphology0.44618224
93MP0001188_hyperpigmentation0.44230428
94MP0003861_abnormal_nervous_system0.42718571
95MP0001529_abnormal_vocalization0.42076009
96MP0005646_abnormal_pituitary_gland0.41653776
97MP0001501_abnormal_sleep_pattern0.41579135
98MP0003633_abnormal_nervous_system0.38595408
99MP0004811_abnormal_neuron_physiology0.38250347
100MP0002928_abnormal_bile_duct0.36149967

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)7.17535532
2Dynein arm defect of respiratory motile cilia (HP:0012255)6.44357893
3Absent/shortened dynein arms (HP:0200106)6.44357893
4Abnormal ciliary motility (HP:0012262)5.88624836
5Abnormal respiratory motile cilium physiology (HP:0012261)5.72684889
6Abnormal respiratory epithelium morphology (HP:0012253)5.56164815
7Abnormal respiratory motile cilium morphology (HP:0005938)5.56164815
8Male infertility (HP:0003251)5.27189591
9Tubulointerstitial nephritis (HP:0001970)5.22839427
10Infertility (HP:0000789)5.16079137
11Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.97023373
12Bony spicule pigmentary retinopathy (HP:0007737)4.85589874
13Attenuation of retinal blood vessels (HP:0007843)4.46164881
14Chronic hepatic failure (HP:0100626)4.43156159
15Hyperkalemia (HP:0002153)4.30822956
16Rhinitis (HP:0012384)4.20546334
17Nasal polyposis (HP:0100582)4.19136394
18Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.02968116
19Resting tremor (HP:0002322)3.95502139
20Asymmetric septal hypertrophy (HP:0001670)3.84717566
21Myokymia (HP:0002411)3.83821125
22Azoospermia (HP:0000027)3.81335414
23Bell-shaped thorax (HP:0001591)3.78150221
24Abnormality of macular pigmentation (HP:0008002)3.76089769
25Abnormal rod and cone electroretinograms (HP:0008323)3.74419430
26Impulsivity (HP:0100710)3.72314187
27Cone-rod dystrophy (HP:0000548)3.67556111
28Abnormal spermatogenesis (HP:0008669)3.51556391
29Nephronophthisis (HP:0000090)3.29542791
30Potter facies (HP:0002009)3.24659865
31Facial shape deformation (HP:0011334)3.24659865
32Abnormality of the nasal mucosa (HP:0000433)3.24630599
33Aplasia/Hypoplasia of the earlobes (HP:0009906)2.94643790
34Osteomalacia (HP:0002749)2.89027219
35Sensory axonal neuropathy (HP:0003390)2.88926707
36Generalized aminoaciduria (HP:0002909)2.87462280
37Postural instability (HP:0002172)2.85036071
38Progressive sensorineural hearing impairment (HP:0000408)2.75452354
39Bronchiectasis (HP:0002110)2.74532505
40Hypoplasia of the thymus (HP:0000778)2.71260400
41Hypoplastic ischia (HP:0003175)2.70043159
42Truncal obesity (HP:0001956)2.64246953
43Chronic bronchitis (HP:0004469)2.63479032
44Abnormality of the renal medulla (HP:0100957)2.63451311
45Enlarged epiphyses (HP:0010580)2.61480717
46Hypophosphatemic rickets (HP:0004912)2.57634773
47Tubulointerstitial abnormality (HP:0001969)2.51348110
48Hypoalphalipoproteinemia (HP:0003233)2.49553109
49Insulin-resistant diabetes mellitus (HP:0000831)2.47493720
50Menstrual irregularities (HP:0000858)2.47317132
51Renovascular hypertension (HP:0100817)2.46220021
52Progressive cerebellar ataxia (HP:0002073)2.44612334
53Abnormal urine output (HP:0012590)2.35804883
54Abnormality of the ischium (HP:0003174)2.32583140
55Abnormality of potassium homeostasis (HP:0011042)2.32450984
56Renal dysplasia (HP:0000110)2.32365167
57Abnormality of the aortic arch (HP:0012303)2.24996531
58Unilateral renal agenesis (HP:0000122)2.24077263
59Stage 5 chronic kidney disease (HP:0003774)2.22675021
60Abnormality of abdominal situs (HP:0011620)2.22192736
61Abdominal situs inversus (HP:0003363)2.22192736
62Renal Fanconi syndrome (HP:0001994)2.21724776
63Amelogenesis imperfecta (HP:0000705)2.16644751
64Congenital malformation of the right heart (HP:0011723)2.15193643
65Double outlet right ventricle (HP:0001719)2.15193643
66Abnormal drinking behavior (HP:0030082)2.14197581
67Polydipsia (HP:0001959)2.14197581
68Abnormality of renal excretion (HP:0011036)2.08701376
69Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.02682936
70Occipital encephalocele (HP:0002085)1.94633138
71Portal hypertension (HP:0001409)1.92589815
72Abnormality of the costochondral junction (HP:0000919)1.91173491
73Spastic paraparesis (HP:0002313)1.90803398
74Polyuria (HP:0000103)1.88352363
75Abnormality of dental color (HP:0011073)1.86751297
76Hyponatremia (HP:0002902)1.82382824
77Horizontal nystagmus (HP:0000666)1.81499611
78Short ribs (HP:0000773)1.80309998
79Atelectasis (HP:0100750)1.79996216
80Progressive hearing impairment (HP:0001730)1.79358329
81Aplasia/Hypoplasia of the sacrum (HP:0008517)1.77120780
82Hyperuricemia (HP:0002149)1.75673167
83Increased purine levels (HP:0004368)1.75673167
84Optic nerve hypoplasia (HP:0000609)1.75562862
85Abnormality of the hepatic vasculature (HP:0006707)1.74374288
86Anterior segment dysgenesis (HP:0007700)1.73989698
87Peripheral hypomyelination (HP:0007182)1.73767287
88Decreased central vision (HP:0007663)1.72905465
89Recurrent pneumonia (HP:0006532)1.65638592
90Median cleft lip (HP:0000161)1.64635015
91Photophobia (HP:0000613)1.64432019
92Glycosuria (HP:0003076)1.62136575
93Abnormality of urine glucose concentration (HP:0011016)1.62136575
94Intellectual disability, moderate (HP:0002342)1.62031992
95Upper limb muscle weakness (HP:0003484)1.60233089
96Transposition of the great arteries (HP:0001669)1.59415169
97Abnormal connection of the cardiac segments (HP:0011545)1.59415169
98Abnormal ventriculo-arterial connection (HP:0011563)1.59415169
99Abnormality of renal resorption (HP:0011038)1.58872065
100Chronic sinusitis (HP:0011109)1.58300564

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK46.82014995
2TESK16.15002153
3STK384.15996558
4PNCK3.97977562
5DDR23.84554602
6PRKD32.91784061
7MAP3K92.91063517
8CAMK1G2.68796883
9MAPK152.62322481
10STK38L2.45125126
11PLK22.44881526
12ARAF2.29481784
13INSRR2.24876278
14MAP4K22.10970120
15NEK62.09633118
16MST1R2.05550603
17BRD41.94487810
18MAP3K131.70766959
19KSR21.70641978
20PDPK11.61151170
21BRAF1.57232562
22CDK71.54694962
23PDK11.49061412
24PTK2B1.33723317
25MET1.29364289
26SIK21.27292696
27CDK121.26758613
28WNK11.24977678
29DYRK1B1.09271502
30AKT31.05940575
31MAP3K41.01951747
32LATS20.94427606
33WNK40.92245245
34CAMK1D0.87805878
35CASK0.86416577
36STK390.85009813
37BMPR1B0.83906779
38TYRO30.75968796
39PRKG10.67829242
40CAMK10.65841058
41PRKCZ0.65514857
42MAP3K80.64167715
43AURKA0.63382044
44MUSK0.62115578
45CDK20.60603319
46MAP3K20.60004969
47PIK3CG0.57097032
48PRKCG0.57071231
49UHMK10.56355330
50RPS6KA20.55946521
51NTRK30.55525217
52RPS6KA10.52885403
53BRSK10.51639310
54GSK3B0.51579333
55MARK10.51348818
56RIPK40.50341255
57MAP2K20.50054191
58MOS0.49941782
59MAP3K110.49863239
60CDK10.49244734
61MAP3K10.47463588
62PRKG20.45672470
63MTOR0.45076125
64TESK20.44455398
65NTRK20.40903084
66SGK10.39155611
67CHEK10.37805585
68SGK2230.37115846
69SGK4940.37115846
70ACVR1B0.36335383
71MAPK10.34472997
72CAMK40.33813502
73MAPK80.33804057
74CAMKK10.32394277
75MINK10.31898809
76GRK70.29501339
77CAMK2A0.29123821
78PRKAA20.28803782
79ROCK10.27999734
80CDK30.26294496
81MAPK100.25101699
82MAPK140.25068150
83CDK90.21510055
84MARK20.21172548
85PRKCI0.20870135
86MAP2K10.20773947
87PLK10.20555748
88CAMKK20.20288889
89OXSR10.18467145
90NEK20.18284228
91TNIK0.18096452
92PRKCB0.17884002
93CDK190.16406397
94LATS10.15817691
95CDK40.15318813
96TNK20.15211897
97MAP2K70.14600890
98PRKACA0.14567543
99PRKACB0.14337338
100PRKCQ0.14069867

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000726.87705669
2Fatty acid biosynthesis_Homo sapiens_hsa000616.74299948
3Olfactory transduction_Homo sapiens_hsa047403.46944199
4Dorso-ventral axis formation_Homo sapiens_hsa043202.38828605
5Butanoate metabolism_Homo sapiens_hsa006502.18601428
6Glycerophospholipid metabolism_Homo sapiens_hsa005642.01749197
7Basal transcription factors_Homo sapiens_hsa030221.93132659
8RNA transport_Homo sapiens_hsa030131.87664200
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.81975413
10Nicotine addiction_Homo sapiens_hsa050331.75843098
11Taste transduction_Homo sapiens_hsa047421.71531490
12Oocyte meiosis_Homo sapiens_hsa041141.69160654
13Synaptic vesicle cycle_Homo sapiens_hsa047211.62815549
14Fatty acid degradation_Homo sapiens_hsa000711.45749193
15Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.44742929
16Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.42884286
17Fatty acid metabolism_Homo sapiens_hsa012121.41692840
18Phototransduction_Homo sapiens_hsa047441.39879730
19Phenylalanine metabolism_Homo sapiens_hsa003601.38963422
20Type II diabetes mellitus_Homo sapiens_hsa049301.36012981
21Arginine and proline metabolism_Homo sapiens_hsa003301.29226211
22Cardiac muscle contraction_Homo sapiens_hsa042601.28743911
23Morphine addiction_Homo sapiens_hsa050321.27752318
24Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.27137257
25Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.21887635
26ABC transporters_Homo sapiens_hsa020101.21763681
27Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.18262626
28Circadian entrainment_Homo sapiens_hsa047131.10953649
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.06840976
30Glutamatergic synapse_Homo sapiens_hsa047241.05556737
31Adipocytokine signaling pathway_Homo sapiens_hsa049201.05006721
32Huntingtons disease_Homo sapiens_hsa050161.04862817
33Inositol phosphate metabolism_Homo sapiens_hsa005621.04636007
34Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.02884743
35Calcium signaling pathway_Homo sapiens_hsa040201.02789610
36Arginine biosynthesis_Homo sapiens_hsa002200.90034838
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.89185524
38Salivary secretion_Homo sapiens_hsa049700.88149701
39cAMP signaling pathway_Homo sapiens_hsa040240.87225514
40Aldosterone synthesis and secretion_Homo sapiens_hsa049250.86754428
41Endocytosis_Homo sapiens_hsa041440.84876894
42GABAergic synapse_Homo sapiens_hsa047270.83946679
43Serotonergic synapse_Homo sapiens_hsa047260.83159546
44Selenocompound metabolism_Homo sapiens_hsa004500.82825503
45Estrogen signaling pathway_Homo sapiens_hsa049150.78735315
46Thyroid hormone signaling pathway_Homo sapiens_hsa049190.78136351
47Long-term potentiation_Homo sapiens_hsa047200.76300070
48Amphetamine addiction_Homo sapiens_hsa050310.75641919
49Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.71996140
50Phosphatidylinositol signaling system_Homo sapiens_hsa040700.71347683
51Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.71062888
52Insulin secretion_Homo sapiens_hsa049110.70522780
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.70087813
54PPAR signaling pathway_Homo sapiens_hsa033200.70079376
55Type I diabetes mellitus_Homo sapiens_hsa049400.69832843
56Purine metabolism_Homo sapiens_hsa002300.69039380
57Gastric acid secretion_Homo sapiens_hsa049710.68150382
58Cell cycle_Homo sapiens_hsa041100.65211093
59Protein digestion and absorption_Homo sapiens_hsa049740.62406608
60Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.62329244
61Bile secretion_Homo sapiens_hsa049760.61417500
62Base excision repair_Homo sapiens_hsa034100.60355471
63Hedgehog signaling pathway_Homo sapiens_hsa043400.60008527
64Cholinergic synapse_Homo sapiens_hsa047250.57728603
65Glycerolipid metabolism_Homo sapiens_hsa005610.57343486
66Cocaine addiction_Homo sapiens_hsa050300.56907722
67Maturity onset diabetes of the young_Homo sapiens_hsa049500.55826196
68mRNA surveillance pathway_Homo sapiens_hsa030150.55743071
69Tyrosine metabolism_Homo sapiens_hsa003500.55288193
70VEGF signaling pathway_Homo sapiens_hsa043700.53999821
71Tight junction_Homo sapiens_hsa045300.53145421
72Oxytocin signaling pathway_Homo sapiens_hsa049210.53016192
73MAPK signaling pathway_Homo sapiens_hsa040100.52722581
74Circadian rhythm_Homo sapiens_hsa047100.51818979
75Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.50509217
76Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.48004035
77Fanconi anemia pathway_Homo sapiens_hsa034600.43466833
78mTOR signaling pathway_Homo sapiens_hsa041500.40509408
79cGMP-PKG signaling pathway_Homo sapiens_hsa040220.36264889
80Autoimmune thyroid disease_Homo sapiens_hsa053200.35193976
81Renin-angiotensin system_Homo sapiens_hsa046140.35085009
82Renin secretion_Homo sapiens_hsa049240.34924514
83Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.31420485
84Metabolic pathways_Homo sapiens_hsa011000.30786740
85Long-term depression_Homo sapiens_hsa047300.30675207
86Ovarian steroidogenesis_Homo sapiens_hsa049130.30052828
87Allograft rejection_Homo sapiens_hsa053300.29847210
88Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.27998257
89Antigen processing and presentation_Homo sapiens_hsa046120.27871788
90Nucleotide excision repair_Homo sapiens_hsa034200.25715269
91Acute myeloid leukemia_Homo sapiens_hsa052210.25316717
92Pancreatic secretion_Homo sapiens_hsa049720.24307463
93Regulation of autophagy_Homo sapiens_hsa041400.23638951
94Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.22736239
95Vascular smooth muscle contraction_Homo sapiens_hsa042700.22391228
96Dopaminergic synapse_Homo sapiens_hsa047280.22173852
97Folate biosynthesis_Homo sapiens_hsa007900.21528355
98Retinol metabolism_Homo sapiens_hsa008300.21255888
99RNA polymerase_Homo sapiens_hsa030200.21156670
100Gap junction_Homo sapiens_hsa045400.21142462

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