ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	7.40970572
2	L-phenylalanine catabolic process (GO:0006559)	7.40970572
3	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	7.08324264
4	L-phenylalanine metabolic process (GO:0006558)	7.08324264
5	aromatic amino acid family catabolic process (GO:0009074)	6.79606292
6	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	6.49368321
7	positive regulation of heterotypic cell-cell adhesion (GO:0034116)	6.39941180
8	tryptophan catabolic process (GO:0006569)	6.28375381
9	indole-containing compound catabolic process (GO:0042436)	6.28375381
10	indolalkylamine catabolic process (GO:0046218)	6.28375381
11	kynurenine metabolic process (GO:0070189)	5.99121099
12	tryptophan metabolic process (GO:0006568)	5.95969191
13	protein-lipid complex subunit organization (GO:0071825)	5.83517512
14	bile acid biosynthetic process (GO:0006699)	5.83382184
15	glyoxylate metabolic process (GO:0046487)	5.74061123
16	high-density lipoprotein particle remodeling (GO:0034375)	5.73039217
17	urea metabolic process (GO:0019627)	5.60631588
18	urea cycle (GO:0000050)	5.60631588
19	negative regulation of fibrinolysis (GO:0051918)	5.49916527
20	alpha-linolenic acid metabolic process (GO:0036109)	5.45147357
21	peptidyl-glutamic acid carboxylation (GO:0017187)	5.32557039
22	protein carboxylation (GO:0018214)	5.32557039
23	regulation of fibrinolysis (GO:0051917)	5.29192236
24	cysteine metabolic process (GO:0006534)	5.21759536
25	sulfur amino acid catabolic process (GO:0000098)	5.16175403
26	nitrogen cycle metabolic process (GO:0071941)	5.14366439
27	regulation of cholesterol esterification (GO:0010872)	5.07891531
28	regulation of protein activation cascade (GO:2000257)	5.06763171
29	reverse cholesterol transport (GO:0043691)	5.05776919
30	serine family amino acid catabolic process (GO:0009071)	5.04491865
31	regulation of triglyceride catabolic process (GO:0010896)	5.04230722
32	complement activation, alternative pathway (GO:0006957)	5.03437516
33	bile acid metabolic process (GO:0008206)	5.00686839
34	regulation of plasminogen activation (GO:0010755)	4.98144482
35	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	4.98025414
36	aromatic amino acid family metabolic process (GO:0009072)	4.96620983
37	plasma lipoprotein particle remodeling (GO:0034369)	4.92290679
38	protein-lipid complex remodeling (GO:0034368)	4.92290679
39	macromolecular complex remodeling (GO:0034367)	4.92290679
40	phospholipid efflux (GO:0033700)	4.89122912
41	homocysteine metabolic process (GO:0050667)	4.81123496
42	tyrosine metabolic process (GO:0006570)	4.75561575
43	negative regulation of protein activation cascade (GO:2000258)	4.70455578
44	regulation of complement activation (GO:0030449)	4.69466653
45	negative regulation of sterol transport (GO:0032372)	4.69324911
46	negative regulation of cholesterol transport (GO:0032375)	4.69324911
47	acylglycerol homeostasis (GO:0055090)	4.68528092
48	triglyceride homeostasis (GO:0070328)	4.68528092
49	amino-acid betaine metabolic process (GO:0006577)	4.64844757
50	lipoprotein metabolic process (GO:0042157)	4.63610157
51	alpha-amino acid catabolic process (GO:1901606)	4.59504512
52	lysine catabolic process (GO:0006554)	4.53642188
53	lysine metabolic process (GO:0006553)	4.53642188
54	indolalkylamine metabolic process (GO:0006586)	4.51393738
55	cellular ketone body metabolic process (GO:0046950)	4.50028076
56	cellular biogenic amine catabolic process (GO:0042402)	4.45185547
57	amine catabolic process (GO:0009310)	4.45185547
58	cellular glucuronidation (GO:0052695)	4.44244707
59	cholesterol efflux (GO:0033344)	4.42951152
60	plasma lipoprotein particle clearance (GO:0034381)	4.36911465
61	cholesterol transport (GO:0030301)	4.36278365
62	sterol transport (GO:0015918)	4.36278365
63	intestinal absorption (GO:0050892)	4.35218710
64	coenzyme catabolic process (GO:0009109)	4.35006353
65	regulation of apoptotic cell clearance (GO:2000425)	4.35003324
66	epoxygenase P450 pathway (GO:0019373)	4.32071836
67	bile acid and bile salt transport (GO:0015721)	4.31278909
68	imidazole-containing compound metabolic process (GO:0052803)	4.30421603
69	glycine metabolic process (GO:0006544)	4.25897763
70	cellular amino acid catabolic process (GO:0009063)	4.21244454
71	negative regulation of hemostasis (GO:1900047)	4.21099960
72	negative regulation of blood coagulation (GO:0030195)	4.21099960
73	regulation of heterotypic cell-cell adhesion (GO:0034114)	4.18515188
74	plasma lipoprotein particle assembly (GO:0034377)	4.18402438
75	diacylglycerol metabolic process (GO:0046339)	4.17117249
76	drug catabolic process (GO:0042737)	4.15306302
77	benzene-containing compound metabolic process (GO:0042537)	4.14086841
78	glutamate metabolic process (GO:0006536)	4.12606025
79	serine family amino acid metabolic process (GO:0009069)	4.09579369
80	aldehyde catabolic process (GO:0046185)	4.03976922
81	positive regulation of lipoprotein lipase activity (GO:0051006)	4.03440513
82	positive regulation of triglyceride lipase activity (GO:0061365)	4.03440513
83	low-density lipoprotein particle remodeling (GO:0034374)	4.03322443
84	arginine metabolic process (GO:0006525)	4.01554597
85	very-low-density lipoprotein particle assembly (GO:0034379)	3.98895962
86	regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)	3.98417313
87	serine family amino acid biosynthetic process (GO:0009070)	3.97928765
88	ethanol oxidation (GO:0006069)	3.96331454
89	glucuronate metabolic process (GO:0019585)	3.96136607
90	uronic acid metabolic process (GO:0006063)	3.96136607
91	cellular modified amino acid catabolic process (GO:0042219)	3.96028222
92	lipoprotein transport (GO:0042953)	3.91943357
93	dicarboxylic acid biosynthetic process (GO:0043650)	3.91212322
94	positive regulation of steroid metabolic process (GO:0045940)	3.91107789
95	positive regulation of fatty acid biosynthetic process (GO:0045723)	3.89152799
96	negative regulation of coagulation (GO:0050819)	3.89055078
97	ketone body metabolic process (GO:1902224)	3.88598896
98	regulation of humoral immune response (GO:0002920)	3.87552092
99	fibrinolysis (GO:0042730)	3.86889561
100	regulation of bile acid biosynthetic process (GO:0070857)	3.85822716
101	acute-phase response (GO:0006953)	3.80292259
102	regulation of cholesterol homeostasis (GO:2000188)	3.79947514
103	negative regulation of lipase activity (GO:0060192)	3.79735067
104	cholesterol homeostasis (GO:0042632)	3.76575343
105	plasma lipoprotein particle organization (GO:0071827)	3.76530330
106	positive regulation of lipid catabolic process (GO:0050996)	3.75633723
107	NAD biosynthetic process (GO:0009435)	3.75396791
108	blood coagulation, intrinsic pathway (GO:0007597)	3.74432658
109	cofactor catabolic process (GO:0051187)	3.73412098
110	positive regulation of blood coagulation (GO:0030194)	3.73074651
111	positive regulation of hemostasis (GO:1900048)	3.73074651
112	regulation of cytokine secretion involved in immune response (GO:0002739)	3.71504152
113	carboxylic acid catabolic process (GO:0046395)	3.71362699
114	organic acid catabolic process (GO:0016054)	3.71362699
115	protein-lipid complex assembly (GO:0065005)	3.70178651
116	phospholipid homeostasis (GO:0055091)	3.70131810
117	sterol homeostasis (GO:0055092)	3.70075092
118	negative regulation of wound healing (GO:0061045)	3.69655851
119	response to nitrosative stress (GO:0051409)	3.64131933
120	short-chain fatty acid metabolic process (GO:0046459)	3.64126426
121	flavonoid metabolic process (GO:0009812)	3.62220575
122	pyridine nucleotide biosynthetic process (GO:0019363)	3.62002605
123	nicotinamide nucleotide biosynthetic process (GO:0019359)	3.62002605
124	proline metabolic process (GO:0006560)	3.61813958
125	lipid homeostasis (GO:0055088)	3.59209274
126	protein activation cascade (GO:0072376)	3.58963981
127	complement activation, classical pathway (GO:0006958)	3.57762263
128	intestinal cholesterol absorption (GO:0030299)	3.56436379
129	positive regulation of coagulation (GO:0050820)	3.45053788
130	neutral lipid catabolic process (GO:0046461)	3.38144608
131	acylglycerol catabolic process (GO:0046464)	3.38144608
132	negative regulation of complement activation (GO:0045916)	3.29179061
133	exogenous drug catabolic process (GO:0042738)	3.28142246
134	ethanol metabolic process (GO:0006067)	3.27037097
135	regulation of cholesterol biosynthetic process (GO:0045540)	3.24725945
136	regulation of lipoprotein particle clearance (GO:0010984)	3.21299387
137	L-ascorbic acid metabolic process (GO:0019852)	3.15341215
138	negative regulation of lipid transport (GO:0032369)	3.12438144
139	complement activation (GO:0006956)	3.12262709
140	omega-hydroxylase P450 pathway (GO:0097267)	3.05525770
141	regulation of cholesterol metabolic process (GO:0090181)	3.01166685

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	RXR_22158963_ChIP-Seq_LIVER_Mouse	8.28476030
2	EGR1_23403033_ChIP-Seq_LIVER_Mouse	7.26592329
3	PPARA_22158963_ChIP-Seq_LIVER_Mouse	7.09026679
4	LXR_22158963_ChIP-Seq_LIVER_Mouse	6.39768881
5	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	5.25231779
6	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	5.17718468
7	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	4.45928883
8	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	4.11075875
9	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	4.09084547
10	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	2.30081897
11	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	2.01052390
12	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	2.00654522
13	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	11.6985307
14	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.86517967
15	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.79791193
16	ZNF263_19887448_ChIP-Seq_K562_Human	1.68452580
17	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.65750106
18	HTT_18923047_ChIP-ChIP_STHdh_Human	1.64615629
19	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.58954603
20	GATA1_22025678_ChIP-Seq_K562_Human	1.58912778
21	GATA6_25053715_ChIP-Seq_YYC3_Human	1.54966546
22	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.54857306
23	HNF4A_19822575_ChIP-Seq_HepG2_Human	1.42763448
24	AR_21909140_ChIP-Seq_LNCAP_Human	1.37171249
25	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.34249995
26	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.29328550
27	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.27037776
28	RXRA_24833708_ChIP-Seq_LIVER_Mouse	1.23008981
29	CLOCK_20551151_ChIP-Seq_293T_Human	1.19613198
30	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.11995084
31	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.08057138
32	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.07502237
33	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.05936461
34	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.04627155
35	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.03354265
36	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.03256762
37	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.02765618
38	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.02010381
39	HIF1A_21447827_ChIP-Seq_MCF-7_Human	0.99143518
40	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	0.98800007
41	SOX2_20726797_ChIP-Seq_SW620_Human	0.97215116
42	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.97192099
43	TP53_16413492_ChIP-PET_HCT116_Human	0.97176604
44	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	0.89247800
45	SOX2_27498859_Chip-Seq_STOMACH_Mouse	0.87779907
46	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	0.86075661
47	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	0.85724185
48	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.85619767
49	ESR1_15608294_ChIP-ChIP_MCF-7_Human	0.84557999
50	GATA4_25053715_ChIP-Seq_YYC3_Human	0.82465967
51	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.81087118
52	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.79591865
53	RARA_24833708_ChIP-Seq_LIVER_Mouse	0.76307844
54	CTNNB1_20460455_ChIP-Seq_HCT116_Human	0.74308963
55	PPAR_26484153_Chip-Seq_NCI-H1993_Human	0.73670679
56	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.72763184
57	RARG_19884340_ChIP-ChIP_MEFs_Mouse	0.69437497
58	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.68835470
59	POU5F1_16518401_ChIP-PET_MESCs_Mouse	0.68379040
60	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	0.68124460
61	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.68093051
62	EOMES_21245162_ChIP-Seq_HESCs_Human	0.67758877
63	SMAD1_18555785_Chip-Seq_ESCs_Mouse	0.67721366
64	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.67625524
65	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.67625524
66	TRIM28_21343339_ChIP-Seq_HEK293_Human	0.67432228
67	SOX17_20123909_ChIP-Seq_XEN_Mouse	0.67241662
68	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	0.66974738
69	NFIB_24661679_ChIP-Seq_LUNG_Mouse	0.66595410
70	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.66355939
71	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	0.66070331
72	CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	0.65853122
73	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	0.65811741
74	SALL4_18804426_ChIP-ChIP_XEN_Mouse	0.65557256
75	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.65046302
76	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.64703903
77	RARB_24833708_ChIP-Seq_LIVER_Mouse	0.64372183
78	AR_20517297_ChIP-Seq_VCAP_Human	0.63965728
79	CEBPB_22108803_ChIP-Seq_LS180_Human	0.62125077
80	STAT1_17558387_ChIP-Seq_HELA_Human	0.61990472
81	TAF15_26573619_Chip-Seq_HEK293_Human	0.61628744
82	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	0.61452658
83	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.60849048
84	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.60788907
85	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.59317117
86	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	0.59212125
87	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.59055855
88	SOX11_22085726_ChIP-Seq_ESNs_Mouse	0.58529243
89	CSB_26484114_Chip-Seq_FIBROBLAST_Human	0.58253202
90	GATA3_24758297_ChIP-Seq_MCF-7_Human	0.57899150
91	ZFX_18555785_Chip-Seq_ESCs_Mouse	0.57745437
92	CDX2_20551321_ChIP-Seq_CACO-2_Human	0.56358940
93	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.56241020
94	MYC_19915707_ChIP-ChIP_AK7_Human	0.56053753
95	CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	0.54963505
96	SOX2_22085726_ChIP-Seq_NPCs_Mouse	0.54592062
97	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	0.53926261
98	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.53515439
99	JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse	0.53279705
100	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.52446271
101	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	0.52283085
102	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.52218280
103	ESRRB_18555785_Chip-Seq_ESCs_Mouse	0.51896344
104	CBP_21632823_ChIP-Seq_H3396_Human	0.51403588
105	RAC3_21632823_ChIP-Seq_H3396_Human	0.51147681
106	SOX2_21211035_ChIP-Seq_LN229_Human	0.50925223
107	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.50767727
108	PPARG_20887899_ChIP-Seq_3T3-L1_Mouse	0.50723953
109	IRF1_19129219_ChIP-ChIP_H3396_Human	0.49928392
110	ESET_19884257_ChIP-Seq_ESCs_Mouse	0.49813612
111	FOXA1_25552417_ChIP-Seq_VCAP_Human	0.49366815
112	EGR1_19032775_ChIP-ChIP_M12_Human	0.49189547
113	FOXA1_26743006_Chip-Seq_LNCaP-abl_Human	0.48990320
114	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.47970008
115	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.47925382
116	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.47719333
117	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	0.47168295
118	ESR1_20079471_ChIP-ChIP_T-47D_Human	0.47136119
119	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.46529464
120	P53_21459846_ChIP-Seq_SAOS-2_Human	0.45118466
121	ESR2_21235772_ChIP-Seq_MCF-7_Human	0.43960438
122	STAT3_1855785_ChIP-Seq_MESCs_Mouse	0.42508823
123	RUNX1_27457419_Chip-Seq_LIVER_Mouse	0.41635132
124	CDX2_22108803_ChIP-Seq_LS180_Human	0.41475461
125	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	0.41250556
126	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.41129743
127	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.40678984
128	TAF2_19829295_ChIP-Seq_ESCs_Human	0.40460730
129	NCOR_22424771_ChIP-Seq_293T_Human	0.40204576
130	BCAT_22108803_ChIP-Seq_LS180_Human	0.39723872
131	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	0.39285724
132	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	0.38939320
133	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.38866614
134	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.38660826
135	ESR1_21235772_ChIP-Seq_MCF-7_Human	0.38111614
136	LUZP1_20508642_ChIP-Seq_ESCs_Mouse	0.37898643
137	MYC_27129775_Chip-Seq_CORNEA_Mouse	0.37046892
138	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.36817586
139	GATA1_19941827_ChIP-Seq_MEL_Mouse	0.36108787
140	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.36092933

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	8.38946238
2	MP0005360_urolithiasis	7.73932589
3	MP0005085_abnormal_gallbladder_physiolo	6.40861386
4	MP0005365_abnormal_bile_salt	6.22813411
5	MP0008875_abnormal_xenobiotic_pharmacok	5.10716652
6	MP0003806_abnormal_nucleotide_metabolis	4.19925634
7	MP0003252_abnormal_bile_duct	3.90537256
8	MP0010329_abnormal_lipoprotein_level	3.61963966
9	MP0003122_maternal_imprinting	3.26269135
10	MP0009840_abnormal_foam_cell	3.11829344
11	MP0005083_abnormal_biliary_tract	3.09133785
12	MP0003195_calcinosis	2.83596843
13	MP0005332_abnormal_amino_acid	2.82148349
14	MP0001666_abnormal_nutrient_absorption	2.67312712
15	MP0004019_abnormal_vitamin_homeostasis	2.28838667
16	MP0003191_abnormal_cellular_cholesterol	2.25309376
17	MP0000609_abnormal_liver_physiology	2.11614676
18	MP0002118_abnormal_lipid_homeostasis	2.05439051
19	MP0002138_abnormal_hepatobiliary_system	2.01289202
20	MP0009697_abnormal_copulation	1.98972987
21	MP0003123_paternal_imprinting	1.84400042
22	MP0003868_abnormal_feces_composition	1.84076742
23	MP0005319_abnormal_enzyme/_coenzyme	1.80389508
24	MP0001764_abnormal_homeostasis	1.74783415
25	MP0005058_abnormal_lysosome_morphology	1.57710003
26	MP0005451_abnormal_body_composition	1.55743141
27	MP0005584_abnormal_enzyme/coenzyme_acti	1.52830517
28	MP0000566_synostosis	1.51069851
29	MP0002089_abnormal_postnatal_growth/wei	1.50144317
30	MP0001915_intracranial_hemorrhage	1.43058837
31	MP0003011_delayed_dark_adaptation	1.32620542
32	MP0003186_abnormal_redox_activity	1.30977723
33	MP0009643_abnormal_urine_homeostasis	1.29746732
34	MP0009764_decreased_sensitivity_to	1.18664657
35	MP0003172_abnormal_lysosome_physiology	1.15344100
36	MP0005647_abnormal_sex_gland	1.14039951
37	MP0000598_abnormal_liver_morphology	1.13417070
38	MP0002876_abnormal_thyroid_physiology	1.12373623
39	MP0005084_abnormal_gallbladder_morpholo	1.08451618
40	MP0005409_darkened_coat_color	1.07856082
41	MP0006054_spinal_hemorrhage	1.06489969
42	MP0004272_abnormal_basement_membrane	1.03983248
43	MP0003656_abnormal_erythrocyte_physiolo	1.03047223
44	MP0005636_abnormal_mineral_homeostasis	1.01461931
45	MP0009763_increased_sensitivity_to	1.00025688
46	MP0003183_abnormal_peptide_metabolism	0.97676822
47	MP0010368_abnormal_lymphatic_system	0.96958736
48	MP0001986_abnormal_taste_sensitivity	0.96379865
49	MP0005408_hypopigmentation	0.92061431
50	MP0002254_reproductive_system_inflammat	0.90498078
51	MP0008469_abnormal_protein_level	0.90060022
52	MP0000604_amyloidosis	0.89651668
53	MP0009780_abnormal_chondrocyte_physiolo	0.88530290
54	MP0009642_abnormal_blood_homeostasis	0.88274586
55	MP0003121_genomic_imprinting	0.87128970
56	MP0003941_abnormal_skin_development	0.84605623
57	MP0005670_abnormal_white_adipose	0.83966662
58	MP0009765_abnormal_xenobiotic_induced	0.83959606
59	MP0006036_abnormal_mitochondrial_physio	0.82582043
60	MP0003705_abnormal_hypodermis_morpholog	0.79880331
61	MP0003315_abnormal_perineum_morphology	0.78201789
62	MP0005376_homeostasis/metabolism_phenot	0.77648288
63	MP0002078_abnormal_glucose_homeostasis	0.75928371
64	MP0002938_white_spotting	0.74772334
65	MP0001661_extended_life_span	0.71415920
66	MP0005164_abnormal_response_to	0.71216266
67	MP0005220_abnormal_exocrine_pancreas	0.69114697
68	MP0003567_abnormal_fetal_cardiomyocyte	0.69086675
69	MP0005334_abnormal_fat_pad	0.68951397
70	MP0001756_abnormal_urination	0.68930692
71	MP0003879_abnormal_hair_cell	0.68382676
72	MP0005410_abnormal_fertilization	0.65693393
73	MP0005535_abnormal_body_temperature	0.65258913
74	MP0002971_abnormal_brown_adipose	0.62157926
75	MP0006035_abnormal_mitochondrial_morpho	0.61906848
76	MP0003950_abnormal_plasma_membrane	0.61170181
77	MP0005266_abnormal_metabolism	0.60525988
78	MP0009053_abnormal_anal_canal	0.59917762
79	MP0002909_abnormal_adrenal_gland	0.59116087
80	MP0005464_abnormal_platelet_physiology	0.58408296
81	MP0009384_cardiac_valve_regurgitation	0.58174926
82	MP0005448_abnormal_energy_balance	0.57429233
83	MP0001270_distended_abdomen	0.55873572
84	MP0002822_catalepsy	0.55573153
85	MP0005257_abnormal_intraocular_pressure	0.54482207
86	MP0005167_abnormal_blood-brain_barrier	0.53501147
87	MP0003718_maternal_effect	0.53409846
88	MP0002136_abnormal_kidney_physiology	0.53264337
89	MP0003724_increased_susceptibility_to	0.52249089
90	MP0002928_abnormal_bile_duct	0.51471366
91	MP0000639_abnormal_adrenal_gland	0.51470368
92	MP0004782_abnormal_surfactant_physiolog	0.51126842
93	MP0005377_hearing/vestibular/ear_phenot	0.49381312
94	MP0003878_abnormal_ear_physiology	0.49381312
95	MP0005395_other_phenotype	0.49147673
96	MP0000920_abnormal_myelination	0.48942611
97	MP0004381_abnormal_hair_follicle	0.47170317
98	MP0003690_abnormal_glial_cell	0.46134835
99	MP0004130_abnormal_muscle_cell	0.45578911
100	MP0005023_abnormal_wound_healing	0.45541385
101	MP0003632_abnormal_nervous_system	0.45209032
102	MP0003638_abnormal_response/metabolism_	0.44601034
103	MP0002132_abnormal_respiratory_system	0.44166647
104	MP0003436_decreased_susceptibility_to	0.44090193
105	MP0008872_abnormal_physiological_respon	0.42638636
106	MP0003953_abnormal_hormone_level	0.42554197
107	MP0005551_abnormal_eye_electrophysiolog	0.42390510
108	MP0008874_decreased_physiological_sensi	0.40490708
109	MP0008873_increased_physiological_sensi	0.39886115
110	MP0003329_amyloid_beta_deposits	0.39516248
111	MP0003699_abnormal_female_reproductive	0.38961698
112	MP0005248_abnormal_Harderian_gland	0.37299300
113	MP0002090_abnormal_vision	0.36994117
114	MP0003890_abnormal_embryonic-extraembry	0.36985836
115	MP0000371_diluted_coat_color	0.36503439
116	MP0008260_abnormal_autophagy	0.36466389
117	MP0002697_abnormal_eye_size	0.36187848
118	MP0004264_abnormal_extraembryonic_tissu	0.34985021
119	MP0000579_abnormal_nail_morphology	0.34031454
120	MP0000230_abnormal_systemic_arterial	0.32210218
121	MP0001881_abnormal_mammary_gland	0.31415662
122	MP0009115_abnormal_fat_cell	0.31290529
123	MP0000249_abnormal_blood_vessel	0.30955342
124	MP0005166_decreased_susceptibility_to	0.30778094
125	MP0001845_abnormal_inflammatory_respons	0.29665371
126	MP0004883_abnormal_blood_vessel	0.29625724
127	MP0009672_abnormal_birth_weight	0.29377840
128	MP0003075_altered_response_to	0.29225882
129	MP0002168_other_aberrant_phenotype	0.28022432
130	MP0002837_dystrophic_cardiac_calcinosis	0.27607378
131	MP0006082_CNS_inflammation	0.27545700
132	MP0001853_heart_inflammation	0.26518283
133	MP0004043_abnormal_pH_regulation	0.25314950
134	MP0002970_abnormal_white_adipose	0.25250665
135	MP0001324_abnormal_eye_pigmentation	0.23488349
136	MP0002135_abnormal_kidney_morphology	0.23154461
137	MP0001243_abnormal_dermal_layer	0.21374713
138	MP0000538_abnormal_urinary_bladder	0.21159714
139	MP0005666_abnormal_adipose_tissue	0.20458132

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of aromatic amino acid family metabolism (HP:0004338)	7.22358980
2	Intrahepatic cholestasis (HP:0001406)	7.19209601
3	Deep venous thrombosis (HP:0002625)	7.09521998
4	Prolonged partial thromboplastin time (HP:0003645)	6.59533021
5	Abnormality of monocarboxylic acid metabolism (HP:0010996)	6.55323037
6	Hypobetalipoproteinemia (HP:0003563)	6.53277521
7	Xanthomatosis (HP:0000991)	6.13655978
8	Hyperlipoproteinemia (HP:0010980)	5.42225550
9	Joint hemorrhage (HP:0005261)	5.09666961
10	Complement deficiency (HP:0004431)	4.95915937
11	Hypolipoproteinemia (HP:0010981)	4.78958124
12	Hyperammonemia (HP:0001987)	4.55811695
13	Hyperglycinemia (HP:0002154)	4.51663407
14	Epidermoid cyst (HP:0200040)	4.38720803
15	Abnormality of the common coagulation pathway (HP:0010990)	4.38719275
16	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	4.36353498
17	Abnormality of glutamine family amino acid metabolism (HP:0010902)	4.31737635
18	Abnormality of sulfur amino acid metabolism (HP:0004339)	4.31386775
19	Abnormality of methionine metabolism (HP:0010901)	4.29159475
20	Ketosis (HP:0001946)	4.23431283
21	Abnormality of aspartate family amino acid metabolism (HP:0010899)	4.22649262
22	Fat malabsorption (HP:0002630)	4.19765972
23	Conjugated hyperbilirubinemia (HP:0002908)	4.13442769
24	Hyperglycinuria (HP:0003108)	4.09544006
25	Hypoglycemic coma (HP:0001325)	4.07594783
26	Hypoalphalipoproteinemia (HP:0003233)	4.07074522
27	Abnormality of serine family amino acid metabolism (HP:0010894)	3.99564294
28	Abnormality of glycine metabolism (HP:0010895)	3.99564294
29	Abnormality of pyrimidine metabolism (HP:0004353)	3.95011150
30	Abnormality of the intrinsic pathway (HP:0010989)	3.76599274
31	Abnormality of complement system (HP:0005339)	3.60986532
32	Hypercholesterolemia (HP:0003124)	3.55823879
33	Abnormality of fatty-acid metabolism (HP:0004359)	3.43723804
34	Hyperbilirubinemia (HP:0002904)	3.36868038
35	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	3.30047332
36	Abnormality of serum amino acid levels (HP:0003112)	3.19353088
37	Abnormality of nucleobase metabolism (HP:0010932)	3.16489970
38	Steatorrhea (HP:0002570)	3.10899208
39	Delayed CNS myelination (HP:0002188)	3.08019108
40	Ketoacidosis (HP:0001993)	3.07154430
41	Spontaneous abortion (HP:0005268)	3.05518680
42	Metabolic acidosis (HP:0001942)	2.94923567
43	Hepatocellular carcinoma (HP:0001402)	2.90952408
44	Hypochromic microcytic anemia (HP:0004840)	2.84886476
45	Abnormality of carpal bone ossification (HP:0006257)	2.84856876
46	Abnormality of purine metabolism (HP:0004352)	2.77229380
47	Myocardial infarction (HP:0001658)	2.76327945
48	Vascular calcification (HP:0004934)	2.73970784
49	Osteomalacia (HP:0002749)	2.72072206
50	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.69500297
51	Dicarboxylic aciduria (HP:0003215)	2.69500297
52	Hypoglycemic seizures (HP:0002173)	2.67788847
53	Lethargy (HP:0001254)	2.66299357
54	Nephritis (HP:0000123)	2.65664161
55	Abnormal tarsal ossification (HP:0008369)	2.64799830
56	Systemic lupus erythematosus (HP:0002725)	2.62488896
57	Broad alveolar ridges (HP:0000187)	2.60749284
58	Skin nodule (HP:0200036)	2.60323948
59	Purpura (HP:0000979)	2.49336201
60	Pancreatic islet-cell hyperplasia (HP:0004510)	2.47773558
61	Acanthocytosis (HP:0001927)	2.47439555
62	Gout (HP:0001997)	2.44574177
63	Cerebral edema (HP:0002181)	2.41189352
64	Cardiovascular calcification (HP:0011915)	2.40259251
65	Malnutrition (HP:0004395)	2.37196487
66	Abnormal delivery (HP:0001787)	2.36665917
67	Increased serum pyruvate (HP:0003542)	2.34870199
68	Gingival bleeding (HP:0000225)	2.33693083
69	Abnormal gallbladder morphology (HP:0012437)	2.33627900
70	Mitral stenosis (HP:0001718)	2.32271928
71	Generalized aminoaciduria (HP:0002909)	2.32063562
72	Arthropathy (HP:0003040)	2.32038517
73	Joint swelling (HP:0001386)	2.32020245
74	Renal cortical cysts (HP:0000803)	2.30898624
75	Hepatoblastoma (HP:0002884)	2.30795340
76	Recurrent gram-negative bacterial infections (HP:0005420)	2.29502464
77	Spastic diplegia (HP:0001264)	2.28309888
78	Irritability (HP:0000737)	2.28181648
79	Glomerulonephritis (HP:0000099)	2.27591527
80	Cholelithiasis (HP:0001081)	2.27321703
81	Sensorimotor neuropathy (HP:0007141)	2.26971529
82	Cholecystitis (HP:0001082)	2.24965981
83	Abnormal gallbladder physiology (HP:0012438)	2.24965981
84	Neonatal onset (HP:0003623)	2.24117933
85	Amyloidosis (HP:0011034)	2.23290825
86	Pancreatitis (HP:0001733)	2.22067020
87	Enlarged kidneys (HP:0000105)	2.21863890
88	Menorrhagia (HP:0000132)	2.20073864
89	Retinal atrophy (HP:0001105)	2.18638376
90	Pigmentary retinal degeneration (HP:0001146)	2.18349904
91	Abnormality of the nasal septum (HP:0000419)	2.17843055
92	Opisthotonus (HP:0002179)	2.16063420
93	Brushfield spots (HP:0001088)	2.12969261
94	Vomiting (HP:0002013)	2.12857863
95	Hyperinsulinemic hypoglycemia (HP:0000825)	2.11806000
96	Esophageal varix (HP:0002040)	2.11199571
97	Abnormal hand bone ossification (HP:0010660)	2.10094640
98	Thrombophlebitis (HP:0004418)	2.07888423
99	Proximal tubulopathy (HP:0000114)	2.05871150
100	Facial shape deformation (HP:0011334)	2.05630418
101	Potter facies (HP:0002009)	2.05630418
102	Broad palm (HP:0001169)	2.04724300
103	Abnormality of glycolysis (HP:0004366)	2.04190641
104	Late onset (HP:0003584)	2.03467968
105	Abnormal ossification of hand bones (HP:0005921)	2.02712911
106	Abnormality of proline metabolism (HP:0010907)	2.01540492
107	Hydroxyprolinuria (HP:0003080)	2.01540492
108	Alkalosis (HP:0001948)	2.01063669
109	Poikilocytosis (HP:0004447)	2.00805067
110	Flat acetabular roof (HP:0003180)	1.99617182
111	Rickets (HP:0002748)	1.99372790
112	Epistaxis (HP:0000421)	1.97884424
113	Hemorrhage of the eye (HP:0011885)	1.96388493
114	Abnormality of the gallbladder (HP:0005264)	1.93550431
115	Glycosuria (HP:0003076)	1.91782054
116	Abnormality of urine glucose concentration (HP:0011016)	1.91782054
117	Hypophosphatemic rickets (HP:0004912)	1.91550933
118	Elevated hepatic transaminases (HP:0002910)	1.90189673
119	Widely patent fontanelles and sutures (HP:0004492)	1.90042301
120	Abnormality of vitamin metabolism (HP:0100508)	1.89837531
121	Symptomatic seizures (HP:0011145)	1.83143910
122	Small epiphyses (HP:0010585)	1.82895788
123	Abnormality of transition element cation homeostasis (HP:0011030)	1.82636315
124	Abnormality of iron homeostasis (HP:0011031)	1.81533420
125	Abnormality of the lumbar spine (HP:0100712)	1.81509949
126	Alacrima (HP:0000522)	1.80786787
127	Abnormality of the Achilles tendon (HP:0005109)	1.80387449
128	Abnormal enzyme/coenzyme activity (HP:0012379)	1.78226466
129	Flared iliac wings (HP:0002869)	1.78143866
130	Vacuolated lymphocytes (HP:0001922)	1.75215442
131	Hyperphosphaturia (HP:0003109)	1.75006484
132	Vaginal fistula (HP:0004320)	1.74274309
133	Diastasis recti (HP:0001540)	1.71826536
134	Hypothermia (HP:0002045)	1.71638081
135	Prenatal maternal abnormality (HP:0002686)	1.68130444
136	Abnormal foot bone ossification (HP:0010675)	1.61175124
137	Pulmonary embolism (HP:0002204)	1.58708564
138	Abnormal urine phosphate concentration (HP:0012599)	1.56847918

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BCKDK	6.77419159
2	PDK2	4.65971009
3	FGFR4	4.55388678
4	INSRR	4.13232576
5	SIK1	3.98981786
6	ERN1	3.76846464
7	ICK	3.07795822
8	TAOK3	2.93059536
9	WNK4	2.89732762
10	CDK12	2.80064424
11	ERBB4	2.73058088
12	PIK3CG	2.47266703
13	MST1R	2.33259677
14	MAP2K4	2.30908651
15	PIK3CA	2.25454110
16	FLT3	2.19408614
17	TYRO3	2.16703513
18	FGFR1	2.09245361
19	PDGFRA	1.90204308
20	STK38L	1.83991099
21	PDPK1	1.72819940
22	FRK	1.69819980
23	ACVR1B	1.69184143
24	MAPK11	1.60878161
25	TESK2	1.59132859
26	EPHA3	1.57723699
27	LATS1	1.55716958
28	TAOK2	1.50507137
29	MAP3K14	1.44473543
30	PINK1	1.43806155
31	MAP3K2	1.42031664
32	TYK2	1.41021415
33	NEK9	1.40989895
34	RET	1.37423388
35	ABL2	1.37368853
36	DAPK2	1.36527426
37	MAP2K3	1.34614497
38	PDK1	1.33151362
39	EIF2AK1	1.33107583
40	WNK1	1.26471333
41	PKN2	1.23521676
42	KDR	1.13665137
43	PRKAA2	1.13330988
44	MAP3K3	1.09167399
45	PTK6	1.09146114
46	JAK2	1.09009535
47	TIE1	1.08627739
48	JAK1	1.07209366
49	LMTK2	1.05777292
50	MAP2K6	1.05124246
51	AKT3	1.04901569
52	ERBB2	1.04788426
53	DDR2	1.04091534
54	IRAK3	1.03197987
55	MAP3K7	0.97737192
56	MAP3K11	0.96955837
57	GRK6	0.96539686
58	TBK1	0.90540962
59	EPHB1	0.86213394
60	FGR	0.85813952
61	PRKCZ	0.85452291
62	FGFR2	0.85124056
63	MAPK4	0.83491052
64	SGK2	0.83006759
65	MAP3K10	0.82282154
66	RIPK1	0.82025992
67	GRK1	0.79292530
68	SGK3	0.79017129
69	CDK7	0.78867625
70	NEK1	0.76268238
71	EEF2K	0.75461945
72	RPS6KB1	0.75173374
73	MAPK15	0.74892587
74	MAP3K12	0.74066463
75	CSNK1E	0.73853576
76	MAPKAPK3	0.73676710
77	NTRK3	0.73221238
78	PRKAA1	0.73121069
79	MET	0.70646485
80	BRSK2	0.70540689
81	EPHA2	0.69729256
82	PBK	0.69578938
83	PRKACG	0.68776963
84	CAMK1D	0.68702855
85	MATK	0.68501226
86	IRAK1	0.68247940
87	MUSK	0.65850603
88	MAP3K5	0.64925491
89	CSK	0.63970175
90	NUAK1	0.63487623
91	CAMK2G	0.60763774
92	STK39	0.60719939
93	IKBKE	0.60110470
94	MAPK7	0.59527737
95	DYRK1B	0.57806101
96	SGK494	0.57557390
97	SGK223	0.57557390
98	BRD4	0.57313093
99	SGK1	0.56933106
100	LATS2	0.56529233
101	MAPK12	0.56230602
102	EIF2AK3	0.55888552
103	SIK2	0.55045914
104	PRKCQ	0.54638570
105	CSNK1D	0.52251705
106	FGFR3	0.51709637
107	MAP2K7	0.51000529
108	IRAK2	0.49419593
109	PRKACB	0.48821358
110	GSK3A	0.47323902
111	PRKG1	0.46724168
112	BRSK1	0.46598234
113	CSNK2A2	0.46576231
114	CDK6	0.46419231
115	BCR	0.46363381
116	CASK	0.45752639
117	CDC42BPA	0.45120512
118	STK16	0.42537276
119	KSR2	0.42516501
120	MAP3K13	0.41751119
121	CDK9	0.41692290
122	KIT	0.41471716
123	IGF1R	0.40871530
124	SRC	0.40523783
125	CSNK2A1	0.39388067
126	CSF1R	0.39194723
127	CAMK4	0.38347965
128	MAP3K1	0.36854984
129	PRKCG	0.35999110
130	NLK	0.35648395
131	MELK	0.34916408
132	TGFBR2	0.34563507
133	MAP2K1	0.33297223
134	PRKCB	0.33015508
135	PDGFRB	0.32409869
136	MTOR	0.32133425
137	SIK3	0.31895458
138	STK3	0.31805493
139	CDK8	0.30723425
140	SCYL2	0.30399835
141	PRKCA	0.30191404
142	PKN1	0.29481560
143	TXK	0.29059974
144	RPS6KA3	0.28460732
145	PRKG2	0.27833277
146	CDK4	0.27399100
147	PTK2	0.26545308
148	NEK6	0.25655761
149	EPHA4	0.24854802
150	CHUK	0.22930330
151	TRIB3	0.21953179
152	PAK3	0.21899364
153	IKBKB	0.21738418
154	MAPK3	0.21395203
155	MAP3K6	0.20360966
156	JAK3	0.20301893

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary bile acid biosynthesis_Homo sapiens_hsa00120	4.42755734
2	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	3.39145333
3	Nitrogen metabolism_Homo sapiens_hsa00910	3.16722563
4	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	3.13951836
5	Arginine biosynthesis_Homo sapiens_hsa00220	2.96192030
6	Tryptophan metabolism_Homo sapiens_hsa00380	2.71966103
7	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	2.69722860
8	Complement and coagulation cascades_Homo sapiens_hsa04610	2.68194805
9	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.60374409
10	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.49459984
11	Fatty acid degradation_Homo sapiens_hsa00071	2.47810031
12	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.41252328
13	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.37787984
14	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.24939896
15	Butanoate metabolism_Homo sapiens_hsa00650	2.16546738
16	Peroxisome_Homo sapiens_hsa04146	2.15666823
17	Chemical carcinogenesis_Homo sapiens_hsa05204	2.02057992
18	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	2.02024010
19	Histidine metabolism_Homo sapiens_hsa00340	2.01631249
20	Steroid hormone biosynthesis_Homo sapiens_hsa00140	2.00196188
21	Propanoate metabolism_Homo sapiens_hsa00640	1.91930371
22	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.87595700
23	PPAR signaling pathway_Homo sapiens_hsa03320	1.84982004
24	Retinol metabolism_Homo sapiens_hsa00830	1.80940504
25	beta-Alanine metabolism_Homo sapiens_hsa00410	1.80381255
26	Fatty acid metabolism_Homo sapiens_hsa01212	1.77933169
27	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.71677463
28	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.69401021
29	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.66665267
30	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.64903196
31	Caffeine metabolism_Homo sapiens_hsa00232	1.61279783
32	Phenylalanine metabolism_Homo sapiens_hsa00360	1.55139782
33	Selenocompound metabolism_Homo sapiens_hsa00450	1.52921588
34	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.50202737
35	Bile secretion_Homo sapiens_hsa04976	1.46145883
36	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.45918439
37	Tyrosine metabolism_Homo sapiens_hsa00350	1.45830504
38	Sulfur metabolism_Homo sapiens_hsa00920	1.41907158
39	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.41307665
40	Pyruvate metabolism_Homo sapiens_hsa00620	1.38632484
41	Fatty acid elongation_Homo sapiens_hsa00062	1.37531147
42	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.31512900
43	Folate biosynthesis_Homo sapiens_hsa00790	1.27192843
44	Fat digestion and absorption_Homo sapiens_hsa04975	1.25598028
45	ABC transporters_Homo sapiens_hsa02010	1.23777595
46	Steroid biosynthesis_Homo sapiens_hsa00100	1.18395749
47	Other glycan degradation_Homo sapiens_hsa00511	1.16815771
48	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.14254672
49	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.11743739
50	Carbon metabolism_Homo sapiens_hsa01200	1.11644340
51	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.09199574
52	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.06398990
53	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.05900826
54	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.05060791
55	Arginine and proline metabolism_Homo sapiens_hsa00330	1.04215169
56	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.98328441
57	Sulfur relay system_Homo sapiens_hsa04122	0.97503909
58	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.96900152
59	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.80956202
60	Lysine degradation_Homo sapiens_hsa00310	0.80880601
61	One carbon pool by folate_Homo sapiens_hsa00670	0.78487819
62	Glutathione metabolism_Homo sapiens_hsa00480	0.74731166
63	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.70531437
64	Glycerolipid metabolism_Homo sapiens_hsa00561	0.67798209
65	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.60627972
66	Pentose phosphate pathway_Homo sapiens_hsa00030	0.58105135
67	Metabolic pathways_Homo sapiens_hsa01100	0.49144784
68	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.48202881
69	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.46168301
70	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.45252769
71	Sphingolipid metabolism_Homo sapiens_hsa00600	0.45077574
72	Galactose metabolism_Homo sapiens_hsa00052	0.37153524
73	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.35435557
74	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.27827521
75	Pertussis_Homo sapiens_hsa05133	0.26899772
76	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.25377507
77	Prion diseases_Homo sapiens_hsa05020	0.25034442
78	Linoleic acid metabolism_Homo sapiens_hsa00591	0.23336080
79	Insulin resistance_Homo sapiens_hsa04931	0.16039927
80	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.14522990
81	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.13106846
82	Protein digestion and absorption_Homo sapiens_hsa04974	0.11832187
83	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.09307318
84	Glucagon signaling pathway_Homo sapiens_hsa04922	0.03812749
85	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.02789291
86	Pyrimidine metabolism_Homo sapiens_hsa00240	-0.2490115
87	Intestinal immune network for IgA production_Homo sapiens_hsa04672	-0.2434007
88	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	-0.2362201
89	Ether lipid metabolism_Homo sapiens_hsa00565	-0.2304711
90	Thyroid hormone synthesis_Homo sapiens_hsa04918	-0.2150079
91	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	-0.1923888
92	Systemic lupus erythematosus_Homo sapiens_hsa05322	-0.1900024
93	Central carbon metabolism in cancer_Homo sapiens_hsa05230	-0.1894134
94	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	-0.1810303
95	Hepatitis C_Homo sapiens_hsa05160	-0.1571306
96	Mineral absorption_Homo sapiens_hsa04978	-0.1487714
97	Insulin signaling pathway_Homo sapiens_hsa04910	-0.1456705
98	African trypanosomiasis_Homo sapiens_hsa05143	-0.1354673
99	Glycosaminoglycan degradation_Homo sapiens_hsa00531	-0.1015359
100	Regulation of autophagy_Homo sapiens_hsa04140	-0.0938435
101	Renin-angiotensin system_Homo sapiens_hsa04614	-0.0872799
102	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	-0.0733881
103	Arachidonic acid metabolism_Homo sapiens_hsa00590	-0.0658292
104	AMPK signaling pathway_Homo sapiens_hsa04152	-0.0624523
105	Ovarian steroidogenesis_Homo sapiens_hsa04913	-0.0536713
106	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	-0.0532232
107	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	-0.0475942
108	ECM-receptor interaction_Homo sapiens_hsa04512	-0.0456032
109	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	-0.0267731

SMLR1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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