SMNDC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a paralog of SMN1 gene, which encodes the survival motor neuron protein, mutations in which are cause of autosomal recessive proximal spinal muscular atrophy. The protein encoded by this gene is a nuclear protein that has been identified as a constituent of the spliceosome complex. This gene is differentially expressed, with abundant levels in skeletal muscle, and may share similar cellular function as the SMN1 gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic sister chromatid cohesion (GO:0007064)4.48150514
2mitotic metaphase plate congression (GO:0007080)4.10965554
3DNA replication checkpoint (GO:0000076)3.83163274
4nuclear pore organization (GO:0006999)3.77054724
5meiotic chromosome segregation (GO:0045132)3.72151623
6kinetochore organization (GO:0051383)3.67430542
7telomere maintenance via semi-conservative replication (GO:0032201)3.59260167
8metaphase plate congression (GO:0051310)3.55804072
9formation of translation preinitiation complex (GO:0001731)3.50474592
10DNA strand elongation involved in DNA replication (GO:0006271)3.50068928
11DNA replication initiation (GO:0006270)3.49344344
12IMP biosynthetic process (GO:0006188)3.47816671
13mitotic nuclear envelope disassembly (GO:0007077)3.46091673
14maturation of SSU-rRNA (GO:0030490)3.45024781
15kinetochore assembly (GO:0051382)3.43777282
16DNA deamination (GO:0045006)3.41110533
17telomere maintenance via recombination (GO:0000722)3.37936932
18ribosomal small subunit assembly (GO:0000028)3.36923283
19chromatin remodeling at centromere (GO:0031055)3.35213499
20CENP-A containing nucleosome assembly (GO:0034080)3.33346856
21regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.33016186
22attachment of spindle microtubules to kinetochore (GO:0008608)3.32802879
23DNA strand elongation (GO:0022616)3.32307859
24IMP metabolic process (GO:0046040)3.29231269
25ribosome biogenesis (GO:0042254)3.25492539
26establishment of chromosome localization (GO:0051303)3.22817142
27regulation of DNA endoreduplication (GO:0032875)3.18828363
28nuclear envelope disassembly (GO:0051081)3.18571249
29membrane disassembly (GO:0030397)3.18571249
30negative regulation of mRNA metabolic process (GO:1903312)3.16919307
31mitotic recombination (GO:0006312)3.16653229
32termination of RNA polymerase III transcription (GO:0006386)3.15063335
33transcription elongation from RNA polymerase III promoter (GO:0006385)3.15063335
34pseudouridine synthesis (GO:0001522)3.14816672
35mitotic chromosome condensation (GO:0007076)3.14103218
36nuclear pore complex assembly (GO:0051292)3.14065912
37mitotic G2/M transition checkpoint (GO:0044818)3.13988582
38protein localization to kinetochore (GO:0034501)3.13933983
39protein neddylation (GO:0045116)3.11588450
40regulation of nuclear cell cycle DNA replication (GO:0033262)3.11132699
41exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.10773523
42histone mRNA metabolic process (GO:0008334)3.09101829
43regulation of mitotic spindle checkpoint (GO:1903504)3.06855120
44regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.06855120
45proteasome assembly (GO:0043248)3.06262741
46mitotic spindle checkpoint (GO:0071174)3.05181018
47DNA replication-independent nucleosome organization (GO:0034724)3.04073770
48DNA replication-independent nucleosome assembly (GO:0006336)3.04073770
49sister chromatid cohesion (GO:0007062)3.02424031
50ribosomal large subunit biogenesis (GO:0042273)3.01046468
51ribonucleoprotein complex biogenesis (GO:0022613)2.99641665
52ether lipid metabolic process (GO:0046485)2.99621393
53negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.96749262
54negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.96593431
55negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.96593431
56negative regulation of mitotic sister chromatid segregation (GO:0033048)2.96593431
57negative regulation of mitotic sister chromatid separation (GO:2000816)2.96593431
58negative regulation of sister chromatid segregation (GO:0033046)2.96593431
59ribosome assembly (GO:0042255)2.94530746
60chromatin assembly or disassembly (GO:0006333)2.94161286
61positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.90615960
62positive regulation of mitotic sister chromatid separation (GO:1901970)2.90615960
63positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.90615960
64positive regulation of chromosome segregation (GO:0051984)2.89929328
65RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.89923601
66negative regulation of mRNA processing (GO:0050686)2.89149427
67nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.88964545
68telomere maintenance via telomere lengthening (GO:0010833)2.87957992
69protein K6-linked ubiquitination (GO:0085020)2.85778618
70maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.84834612
71DNA-templated transcription, termination (GO:0006353)2.84406845
72protein localization to chromosome (GO:0034502)2.84020679
73protein localization to chromosome, centromeric region (GO:0071459)2.83103250
74establishment of protein localization to mitochondrial membrane (GO:0090151)2.82193197
75DNA unwinding involved in DNA replication (GO:0006268)2.80348870
76rRNA processing (GO:0006364)2.79535559
77nucleotide-excision repair, DNA gap filling (GO:0006297)2.78990112
78regulation of sister chromatid segregation (GO:0033045)2.77732902
79regulation of mitotic sister chromatid separation (GO:0010965)2.77732902
80regulation of mitotic sister chromatid segregation (GO:0033047)2.77732902
81mitotic spindle assembly checkpoint (GO:0007094)2.77547264
82regulation of double-strand break repair via homologous recombination (GO:0010569)2.77373368
83regulation of centriole replication (GO:0046599)2.77231274
84spindle assembly checkpoint (GO:0071173)2.76449086
85viral mRNA export from host cell nucleus (GO:0046784)2.76139158
86pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.75667111
87negative regulation of RNA splicing (GO:0033119)2.75610274
88spliceosomal snRNP assembly (GO:0000387)2.75487957
89monoubiquitinated protein deubiquitination (GO:0035520)2.74839758
90cullin deneddylation (GO:0010388)2.74484618
91regulation of spindle organization (GO:0090224)2.72232935
92somatic hypermutation of immunoglobulin genes (GO:0016446)2.71924968
93somatic diversification of immune receptors via somatic mutation (GO:0002566)2.71924968
94viral transcription (GO:0019083)2.71398409
95rRNA metabolic process (GO:0016072)2.71286429
96histone exchange (GO:0043486)2.71010723
97heterochromatin organization (GO:0070828)2.70184648
98sister chromatid segregation (GO:0000819)2.69891858
99pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.69616724
100translational initiation (GO:0006413)2.69102951
101translational termination (GO:0006415)2.68607432
102* RNA splicing, via transesterification reactions (GO:0000375)2.64708682
103regulation of chromosome segregation (GO:0051983)2.64580117
104embryonic process involved in female pregnancy (GO:0060136)2.63690218
105DNA ligation (GO:0006266)2.61162783
106maturation of 5.8S rRNA (GO:0000460)2.60804710
107transcription from mitochondrial promoter (GO:0006390)2.60696139
108RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.60631028
109mRNA splicing, via spliceosome (GO:0000398)2.60631028
110pore complex assembly (GO:0046931)2.59726564
111transcription-coupled nucleotide-excision repair (GO:0006283)2.58315576
112dosage compensation (GO:0007549)2.58096588
113spliceosomal complex assembly (GO:0000245)2.58051955
114termination of RNA polymerase II transcription (GO:0006369)2.57911929
115protein deneddylation (GO:0000338)2.55841770
116folic acid-containing compound biosynthetic process (GO:0009396)2.54443555
117DNA replication-dependent nucleosome organization (GO:0034723)2.53649727
118DNA replication-dependent nucleosome assembly (GO:0006335)2.53649727
119purine nucleobase biosynthetic process (GO:0009113)2.53057003
120replication fork processing (GO:0031297)2.52783253
121regulation of mitotic metaphase/anaphase transition (GO:0030071)2.51846989
122regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.51231391
123histone H4-K12 acetylation (GO:0043983)2.50920075
124nucleobase biosynthetic process (GO:0046112)2.50390798
125DNA topological change (GO:0006265)2.49968427
126nuclear envelope organization (GO:0006998)2.49642192
127mitotic sister chromatid segregation (GO:0000070)2.48359715
128regulation of helicase activity (GO:0051095)2.48092631
129ATP-dependent chromatin remodeling (GO:0043044)2.46168415
130regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.46087712
131nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.45934393
132negative regulation of DNA-dependent DNA replication (GO:2000104)2.43620572
133negative regulation of chromosome segregation (GO:0051985)2.43606191
134ribosomal small subunit biogenesis (GO:0042274)2.42703950
135spindle checkpoint (GO:0031577)2.42493256
136chromosome segregation (GO:0007059)2.42342926
137mismatch repair (GO:0006298)2.40942050
138SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.40654859
139negative regulation by host of viral transcription (GO:0043922)2.40550102
140translational elongation (GO:0006414)2.40456484
141regulation of posttranscriptional gene silencing (GO:0060147)2.39596228
142regulation of gene silencing by miRNA (GO:0060964)2.39596228
143regulation of gene silencing by RNA (GO:0060966)2.39596228

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.13795590
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.92061571
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.70706856
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.52489825
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.35937684
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.13276995
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.74834244
8* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.68709379
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.59523543
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.41924387
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.37525279
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.36593493
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.34873027
14FUS_26573619_Chip-Seq_HEK293_Human2.28863253
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.16671001
16* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.14476863
17* VDR_23849224_ChIP-Seq_CD4+_Human2.10972451
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.10586215
19EWS_26573619_Chip-Seq_HEK293_Human2.08962070
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.05843703
21XRN2_22483619_ChIP-Seq_HELA_Human2.05462699
22KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.04128368
23KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.04128368
24KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.04128368
25* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.93825300
26E2F1_21310950_ChIP-Seq_MCF-7_Human1.93010012
27MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.92500091
28ELF1_17652178_ChIP-ChIP_JURKAT_Human1.91739963
29SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.91205835
30TP63_19390658_ChIP-ChIP_HaCaT_Human1.90286760
31MYC_22102868_ChIP-Seq_BL_Human1.88874054
32NOTCH1_21737748_ChIP-Seq_TLL_Human1.87903883
33DCP1A_22483619_ChIP-Seq_HELA_Human1.85488134
34* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.84122296
35* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.81325507
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.81054607
37ELK1_19687146_ChIP-ChIP_HELA_Human1.80771047
38FOXP3_21729870_ChIP-Seq_TREG_Human1.79947451
39TTF2_22483619_ChIP-Seq_HELA_Human1.77526205
40* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.76975115
41AR_21909140_ChIP-Seq_LNCAP_Human1.73509883
42HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.71142014
43E2F1_18555785_ChIP-Seq_MESCs_Mouse1.71054298
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65822502
45POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.62700147
46GABP_19822575_ChIP-Seq_HepG2_Human1.59683949
47TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.56819466
48RBPJ_22232070_ChIP-Seq_NCS_Mouse1.55313326
49* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.54956874
50* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.52539197
51NANOG_18555785_ChIP-Seq_MESCs_Mouse1.50535524
52POU3F2_20337985_ChIP-ChIP_501MEL_Human1.48611936
53SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.46504092
54SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.46260948
55* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.45512324
56E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.44550024
57SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.38161955
58NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.37110868
59KDM5A_27292631_Chip-Seq_BREAST_Human1.36159705
60CIITA_25753668_ChIP-Seq_RAJI_Human1.35688229
61HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.35444570
62* TFEB_21752829_ChIP-Seq_HELA_Human1.35169647
63* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.34133044
64HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.32283018
65SPI1_23547873_ChIP-Seq_NB4_Human1.31173789
66STAT3_1855785_ChIP-Seq_MESCs_Mouse1.30850465
67IRF1_19129219_ChIP-ChIP_H3396_Human1.29308472
68* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.28679925
69* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.24080315
70SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.23771032
71VDR_21846776_ChIP-Seq_THP-1_Human1.23555466
72* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.21743898
73PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.21391845
74POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.20627794
75TAF15_26573619_Chip-Seq_HEK293_Human1.18800387
76IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.17394749
77ERG_20887958_ChIP-Seq_HPC-7_Mouse1.15584570
78ZNF274_21170338_ChIP-Seq_K562_Hela1.14533036
79FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.13871023
80CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.11556694
81SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.11050483
82SOX2_18555785_ChIP-Seq_MESCs_Mouse1.10330412
83ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.09372016
84GATA1_22025678_ChIP-Seq_K562_Human1.08909297
85MYB_26560356_Chip-Seq_TH2_Human1.07339297
86SALL1_21062744_ChIP-ChIP_HESCs_Human1.06960515
87E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05957680
88MYB_21317192_ChIP-Seq_ERMYB_Mouse1.05229529
89MYB_26560356_Chip-Seq_TH1_Human1.04679590
90POU5F1_16153702_ChIP-ChIP_HESCs_Human1.04017511
91VDR_22108803_ChIP-Seq_LS180_Human1.03958129
92GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.03370240
93YY1_21170310_ChIP-Seq_MESCs_Mouse1.03364111
94PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.02717534
95PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02285600
96* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.02128516
97NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.01049105
98DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.01023429
99SRF_21415370_ChIP-Seq_HL-1_Mouse1.00368281
100FLI1_27457419_Chip-Seq_LIVER_Mouse0.99962603
101KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.99139490
102MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.97923878
103MAF_26560356_Chip-Seq_TH1_Human0.96884686
104NANOG_16153702_ChIP-ChIP_HESCs_Human0.94822191
105IRF8_22096565_ChIP-ChIP_GC-B_Human0.92765056
106TCF3_18692474_ChIP-Seq_MEFs_Mouse0.92764358
107STAT4_19710469_ChIP-ChIP_TH1__Mouse0.91747781
108MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.91325220
109* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.91097927
110CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.90411759
111IRF8_21731497_ChIP-ChIP_J774_Mouse0.90370807
112* ELK1_22589737_ChIP-Seq_MCF10A_Human0.90276769
113HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.89755024
114FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.89054364
115NANOG_21062744_ChIP-ChIP_HESCs_Human0.88907519
116TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.87386438
117POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.87373100
118SOX2_16153702_ChIP-ChIP_HESCs_Human0.86581098
119CHD1_26751641_Chip-Seq_LNCaP_Human0.85985484
120CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.85559469
121SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.85208217
122MYC_18940864_ChIP-ChIP_HL60_Human0.85052220
123SOX17_20123909_ChIP-Seq_XEN_Mouse0.79902846
124* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.79682203
125RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.78232710
126P300_19829295_ChIP-Seq_ESCs_Human0.77030468

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.05558939
2MP0003693_abnormal_embryo_hatching3.92937219
3MP0004957_abnormal_blastocyst_morpholog3.39888488
4MP0010094_abnormal_chromosome_stability3.31905526
5MP0003111_abnormal_nucleus_morphology3.12507710
6MP0003077_abnormal_cell_cycle3.02314247
7MP0008058_abnormal_DNA_repair2.70451601
8MP0008007_abnormal_cellular_replicative2.70028712
9MP0006292_abnormal_olfactory_placode2.13912218
10MP0008932_abnormal_embryonic_tissue2.04439411
11MP0009697_abnormal_copulation1.93732364
12MP0000490_abnormal_crypts_of1.87837461
13MP0010352_gastrointestinal_tract_polyps1.84409058
14MP0003786_premature_aging1.83053576
15MP0000350_abnormal_cell_proliferation1.82403071
16MP0001188_hyperpigmentation1.72621474
17MP0002277_abnormal_respiratory_mucosa1.70266902
18MP0008877_abnormal_DNA_methylation1.69746586
19MP0010307_abnormal_tumor_latency1.68643808
20MP0003763_abnormal_thymus_physiology1.65344523
21MP0009333_abnormal_splenocyte_physiolog1.65185122
22MP0010030_abnormal_orbit_morphology1.65062926
23MP0005084_abnormal_gallbladder_morpholo1.60535634
24MP0009278_abnormal_bone_marrow1.60202228
25MP0001545_abnormal_hematopoietic_system1.59537545
26MP0005397_hematopoietic_system_phenotyp1.59537545
27MP0001730_embryonic_growth_arrest1.57907854
28MP0004808_abnormal_hematopoietic_stem1.57763924
29MP0002396_abnormal_hematopoietic_system1.53317462
30MP0003941_abnormal_skin_development1.50770169
31MP0003123_paternal_imprinting1.47050957
32MP0003937_abnormal_limbs/digits/tail_de1.43031454
33MP0002877_abnormal_melanocyte_morpholog1.41309608
34MP0005076_abnormal_cell_differentiation1.37595917
35MP0002398_abnormal_bone_marrow1.36335829
36MP0001672_abnormal_embryogenesis/_devel1.35238017
37MP0005380_embryogenesis_phenotype1.35238017
38MP0001697_abnormal_embryo_size1.35207365
39MP0003436_decreased_susceptibility_to1.33845394
40MP0003567_abnormal_fetal_cardiomyocyte1.32474537
41MP0000566_synostosis1.29447687
42MP0003136_yellow_coat_color1.27565808
43MP0002019_abnormal_tumor_incidence1.26648639
44MP0004197_abnormal_fetal_growth/weight/1.25446801
45MP0002086_abnormal_extraembryonic_tissu1.25232136
46MP0002233_abnormal_nose_morphology1.24526695
47MP0000313_abnormal_cell_death1.23979108
48MP0002085_abnormal_embryonic_tissue1.23309452
49MP0000703_abnormal_thymus_morphology1.21277613
50MP0002405_respiratory_system_inflammati1.19511247
51MP0003984_embryonic_growth_retardation1.18886622
52MP0005671_abnormal_response_to1.18568875
53MP0003315_abnormal_perineum_morphology1.17872489
54MP0000689_abnormal_spleen_morphology1.17537621
55MP0002084_abnormal_developmental_patter1.17293850
56MP0001293_anophthalmia1.17205985
57MP0002653_abnormal_ependyma_morphology1.15637232
58MP0002088_abnormal_embryonic_growth/wei1.14965603
59MP0006035_abnormal_mitochondrial_morpho1.14901683
60MP0009053_abnormal_anal_canal1.14779041
61MP0005000_abnormal_immune_tolerance1.13958322
62MP0003221_abnormal_cardiomyocyte_apopto1.13845605
63MP0001800_abnormal_humoral_immune1.13815130
64MP0008995_early_reproductive_senescence1.13470338
65MP0002722_abnormal_immune_system1.13463069
66MP0002796_impaired_skin_barrier1.12922887
67MP0000685_abnormal_immune_system1.12764575
68MP0002452_abnormal_antigen_presenting1.11593380
69MP0002080_prenatal_lethality1.10770507
70MP0009785_altered_susceptibility_to1.10590505
71MP0003448_altered_tumor_morphology1.09561941
72MP0006036_abnormal_mitochondrial_physio1.09274188
73MP0000858_altered_metastatic_potential1.08753046
74MP0002009_preneoplasia1.07252119
75MP0002148_abnormal_hypersensitivity_rea1.07144103
76MP0009672_abnormal_birth_weight1.06592728
77MP0002420_abnormal_adaptive_immunity1.06453944
78MP0001819_abnormal_immune_cell1.05968482
79MP0000716_abnormal_immune_system1.05676842
80MP0003755_abnormal_palate_morphology1.03578003
81MP0002723_abnormal_immune_serum1.03059332
82MP0002111_abnormal_tail_morphology1.01911493
83MP0002429_abnormal_blood_cell1.00857224
84MP0000049_abnormal_middle_ear1.00791873
85MP0002210_abnormal_sex_determination0.98991722
86MP0001835_abnormal_antigen_presentation0.96516590
87MP0001346_abnormal_lacrimal_gland0.95961665
88MP0009703_decreased_birth_body0.95622310
89MP0005501_abnormal_skin_physiology0.94868579
90MP0000428_abnormal_craniofacial_morphol0.94805836
91MP0003718_maternal_effect0.94088527
92MP0003890_abnormal_embryonic-extraembry0.93506939
93MP0005387_immune_system_phenotype0.92525229
94MP0001790_abnormal_immune_system0.92525229
95MP0002102_abnormal_ear_morphology0.91606416
96MP0003121_genomic_imprinting0.91605697
97MP0002697_abnormal_eye_size0.91372100
98MP0002234_abnormal_pharynx_morphology0.91056123
99MP0003303_peritoneal_inflammation0.90583951
100MP0003935_abnormal_craniofacial_develop0.89928166
101MP0001929_abnormal_gametogenesis0.88899874
102MP0002006_tumorigenesis0.87842490
103MP0001119_abnormal_female_reproductive0.85918045
104MP0002092_abnormal_eye_morphology0.85469693
105MP0002177_abnormal_outer_ear0.85150864
106MP0005025_abnormal_response_to0.83694511
107MP0010155_abnormal_intestine_physiology0.83136874
108MP0003119_abnormal_digestive_system0.82893667
109MP0003385_abnormal_body_wall0.82772001
110MP0008961_abnormal_basal_metabolism0.82654223
111MP0001145_abnormal_male_reproductive0.82011777
112MP0003453_abnormal_keratinocyte_physiol0.79976529
113MP0005023_abnormal_wound_healing0.79678512
114MP0002132_abnormal_respiratory_system0.78441864
115MP0005187_abnormal_penis_morphology0.77325112
116MP0003787_abnormal_imprinting0.76870523
117MP0003186_abnormal_redox_activity0.76775972
118MP0000465_gastrointestinal_hemorrhage0.76414949
119MP0000516_abnormal_urinary_system0.74467382
120MP0005367_renal/urinary_system_phenotyp0.74467382
121MP0001286_abnormal_eye_development0.74261502
122MP0003566_abnormal_cell_adhesion0.72633196
123MP0002419_abnormal_innate_immunity0.71986136
124MP0000432_abnormal_head_morphology0.71972957
125MP0001853_heart_inflammation0.71843208
126MP0000653_abnormal_sex_gland0.71387035
127MP0001299_abnormal_eye_distance/0.70808299
128MP0006072_abnormal_retinal_apoptosis0.70676381
129MP0003943_abnormal_hepatobiliary_system0.70416792
130MP0002163_abnormal_gland_morphology0.70045369
131MP0009250_abnormal_appendicular_skeleto0.68229011
132MP0000477_abnormal_intestine_morphology0.68048451
133MP0008789_abnormal_olfactory_epithelium0.67717381
134MP0006082_CNS_inflammation0.67361091
135MP0004185_abnormal_adipocyte_glucose0.66594960
136MP0003252_abnormal_bile_duct0.66519617
137MP0000358_abnormal_cell_content/0.65635378
138MP0001324_abnormal_eye_pigmentation0.65208717
139MP0005379_endocrine/exocrine_gland_phen0.65196073
140MP0000631_abnormal_neuroendocrine_gland0.60470390
141MP0004133_heterotaxia0.60015720

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.71447565
2Central scotoma (HP:0000603)3.61232826
3Abnormality of the anterior horn cell (HP:0006802)3.42041800
4Degeneration of anterior horn cells (HP:0002398)3.42041800
5Patellar aplasia (HP:0006443)3.35754053
6Chromsome breakage (HP:0040012)3.27928884
7Hypoplasia of the fovea (HP:0007750)3.25940736
8Aplasia/Hypoplasia of the fovea (HP:0008060)3.25940736
9Chromosomal breakage induced by crosslinking agents (HP:0003221)3.23596349
10Aplasia/Hypoplasia of the patella (HP:0006498)3.14840818
11Congenital stationary night blindness (HP:0007642)3.00286717
12Reticulocytopenia (HP:0001896)2.99994173
13Abnormality of the fovea (HP:0000493)2.96048580
1411 pairs of ribs (HP:0000878)2.92884050
15Absent thumb (HP:0009777)2.88588570
16Breast hypoplasia (HP:0003187)2.88088651
17Severe visual impairment (HP:0001141)2.85224369
18Abnormality of macular pigmentation (HP:0008002)2.83404619
19Abnormality of the ileum (HP:0001549)2.67652056
20Abnormality of chromosome stability (HP:0003220)2.67563078
21Volvulus (HP:0002580)2.67332949
22Meckel diverticulum (HP:0002245)2.61801660
23Aplastic anemia (HP:0001915)2.58106704
24Ectopic kidney (HP:0000086)2.57138202
25Facial hemangioma (HP:0000329)2.56171426
26Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.48204608
27Abnormal rod and cone electroretinograms (HP:0008323)2.48120192
28Rib fusion (HP:0000902)2.45698832
29Scotoma (HP:0000575)2.43872704
30Aplasia/Hypoplasia of the uvula (HP:0010293)2.42162800
31Multiple enchondromatosis (HP:0005701)2.41774791
32Myelodysplasia (HP:0002863)2.37156146
33Absent radius (HP:0003974)2.35080871
34Abnormality of the preputium (HP:0100587)2.29840352
35Albinism (HP:0001022)2.29349118
36Premature graying of hair (HP:0002216)2.25999121
37Increased IgM level (HP:0003496)2.25553636
38Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.25102400
39Missing ribs (HP:0000921)2.23236719
40Carpal bone hypoplasia (HP:0001498)2.21169147
41Septo-optic dysplasia (HP:0100842)2.20616362
42Duodenal stenosis (HP:0100867)2.17263744
43Small intestinal stenosis (HP:0012848)2.17263744
44Absent forearm bone (HP:0003953)2.16995872
45Aplasia involving forearm bones (HP:0009822)2.16995872
46Abnormal number of incisors (HP:0011064)2.16684721
47Abnormality of DNA repair (HP:0003254)2.14166699
48Acute lymphatic leukemia (HP:0006721)2.13975118
49Colon cancer (HP:0003003)2.13785459
50Selective tooth agenesis (HP:0001592)2.12093332
51Abnormal lung lobation (HP:0002101)2.11914305
52Abnormal delayed hypersensitivity skin test (HP:0002963)2.11171213
53Agnosia (HP:0010524)2.08699480
54Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.07138195
55Macrocytic anemia (HP:0001972)2.06781667
56Medulloblastoma (HP:0002885)2.04554569
57Abnormality of T cell physiology (HP:0011840)2.04384018
58Impulsivity (HP:0100710)2.04296094
59Rectovaginal fistula (HP:0000143)2.04236617
60Rectal fistula (HP:0100590)2.04236617
61Bone marrow hypocellularity (HP:0005528)2.03801088
62Abnormality of chromosome segregation (HP:0002916)2.02938570
63Capillary hemangiomas (HP:0005306)2.02012347
64Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.01576768
65Abnormality of alanine metabolism (HP:0010916)2.01576768
66Hyperalaninemia (HP:0003348)2.01576768
67Cleft eyelid (HP:0000625)2.00628158
68Lymphoma (HP:0002665)1.99785220
69Curly hair (HP:0002212)1.99275588
70Aplasia/Hypoplasia of the macula (HP:0008059)1.96997725
71Abnormality of cells of the erythroid lineage (HP:0012130)1.96697566
72Intestinal atresia (HP:0011100)1.96520066
73Rough bone trabeculation (HP:0100670)1.94590659
74Neoplasm of the oral cavity (HP:0100649)1.94441629
75Septate vagina (HP:0001153)1.94166892
76Intestinal fistula (HP:0100819)1.93846012
77Duplicated collecting system (HP:0000081)1.93402073
78Pallor (HP:0000980)1.93306025
79Abnormality of the renal collecting system (HP:0004742)1.93288360
80Short 5th finger (HP:0009237)1.93112665
81Increased hepatocellular lipid droplets (HP:0006565)1.92941828
82Supernumerary spleens (HP:0009799)1.92919500
83Abnormal number of erythroid precursors (HP:0012131)1.92025190
84Abnormality of the phalanges of the 5th finger (HP:0004213)1.90269617
85Low anterior hairline (HP:0000294)1.90264909
86Clubbing of toes (HP:0100760)1.90036849
87Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.88664514
88Horseshoe kidney (HP:0000085)1.87848624
89Renal cortical cysts (HP:0000803)1.86776134
90Triphalangeal thumb (HP:0001199)1.86543573
91Slender long bone (HP:0003100)1.86162492
92Abnormality of the duodenum (HP:0002246)1.84174617
93Median cleft lip (HP:0000161)1.83689445
94Lip pit (HP:0100267)1.83443102
95Trismus (HP:0000211)1.83370114
96Abnormality of T cell number (HP:0011839)1.83049523
97Nephroblastoma (Wilms tumor) (HP:0002667)1.82710808
98Atresia of the external auditory canal (HP:0000413)1.82449424
99Stenosis of the external auditory canal (HP:0000402)1.81773904
100Recurrent fungal infections (HP:0002841)1.81289409
101Abnormality of T cells (HP:0002843)1.81217666
102Rhabdomyosarcoma (HP:0002859)1.80166817
103Long clavicles (HP:0000890)1.79662243
104Gastrointestinal atresia (HP:0002589)1.79307093
105Tracheoesophageal fistula (HP:0002575)1.78942648
106T lymphocytopenia (HP:0005403)1.78888126
107Tongue fasciculations (HP:0001308)1.77684190
108Prominent metopic ridge (HP:0005487)1.77041681
109Oral leukoplakia (HP:0002745)1.76437443
110Increased number of teeth (HP:0011069)1.76433957
111Megaloblastic anemia (HP:0001889)1.75973338
112Acute necrotizing encephalopathy (HP:0006965)1.73944906
113Overlapping toe (HP:0001845)1.73753225
114Long nose (HP:0003189)1.73531432
115Aplasia/Hypoplasia affecting the retina (HP:0008061)1.73272943
116Abnormality of methionine metabolism (HP:0010901)1.73269992
117Acute myeloid leukemia (HP:0004808)1.73069322
118Atrophy/Degeneration involving motor neurons (HP:0007373)1.72887065
119Hypoplasia of the radius (HP:0002984)1.72830698
120Amaurosis fugax (HP:0100576)1.72748269
121Increased CSF lactate (HP:0002490)1.72551442
122Short middle phalanx of the 5th finger (HP:0004220)1.72468533
123Recurrent viral infections (HP:0004429)1.72412097
124Facial cleft (HP:0002006)1.71954299
125Glossoptosis (HP:0000162)1.71176639
126Optic nerve coloboma (HP:0000588)1.71099019
127Progressive muscle weakness (HP:0003323)1.70208405
128Subaortic stenosis (HP:0001682)1.69665333
129Abnormality of the left ventricular outflow tract (HP:0011103)1.69665333
130Basal cell carcinoma (HP:0002671)1.69473879
131Abnormal trabecular bone morphology (HP:0100671)1.69428574
132Irregular epiphyses (HP:0010582)1.69353635
133Choanal atresia (HP:0000453)1.68951962
134Abnormality of the metopic suture (HP:0005556)1.68759071
135Embryonal renal neoplasm (HP:0011794)1.68315515
136Cystic hygroma (HP:0000476)1.67012598
137Abnormality of homocysteine metabolism (HP:0010919)1.66586463
138Homocystinuria (HP:0002156)1.66586463
139Abnormality of the pons (HP:0007361)1.66051901
140Cellular immunodeficiency (HP:0005374)1.66013904
141IgG deficiency (HP:0004315)1.65157692
142Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.63826840
143Lipid accumulation in hepatocytes (HP:0006561)1.63559913
144Abnormal hair whorl (HP:0010721)1.63109932
145Premature ovarian failure (HP:0008209)1.62983311
146Hypoplasia of the pons (HP:0012110)1.61680008
147Cheilitis (HP:0100825)1.61547004
148Short thumb (HP:0009778)1.60440780
149Abnormality of the labia minora (HP:0012880)1.60002090
150Aplasia/Hypoplasia of the sacrum (HP:0008517)1.59632537
151Sloping forehead (HP:0000340)1.59482101
152Neoplasm of the pancreas (HP:0002894)1.59228437
153Maternal diabetes (HP:0009800)1.58533955
154Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.57876507
155Muscle fiber atrophy (HP:0100295)1.57044695
156Elevated erythrocyte sedimentation rate (HP:0003565)1.56809905
157Abnormality of the septum pellucidum (HP:0007375)1.56289472
158Absent septum pellucidum (HP:0001331)1.55981030

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK13.56079083
2CDC73.24206033
3WEE13.20901697
4BUB13.17963313
5BRSK22.54355944
6ACVR1B2.51574399
7TRIM282.49962132
8SRPK12.42545015
9MKNK12.41514211
10WNK32.39491400
11MKNK22.20134748
12RPS6KA42.13394596
13NME22.07822826
14TAF11.99957352
15CDK121.99597746
16PLK41.92763545
17NEK21.92015946
18MAP3K141.81008827
19STK101.74212690
20TNIK1.72777352
21PIM21.70353316
22CDK71.68959852
23PNCK1.56821058
24PLK11.55123259
25EIF2AK31.51189812
26BMPR1B1.49569812
27PDK21.47099486
28DYRK31.46023014
29PIM11.45440830
30BCR1.44490469
31TESK21.43844383
32TTK1.43385025
33RPS6KB21.43199292
34ATR1.39342588
35CLK11.39287522
36TLK11.36874694
37MST41.31890750
38VRK21.31101612
39IRAK41.31022476
40AURKB1.25215434
41TSSK61.24279260
42CCNB11.23659545
43PASK1.19646197
44PLK31.18551594
45FLT31.17001165
46VRK11.16101611
47TXK1.15354516
48JAK31.14271208
49ERBB31.14071211
50FRK1.13022952
51NEK11.11109303
52AKT31.10599670
53CDK41.09360981
54IKBKB1.08813544
55NEK91.04556447
56NLK1.04064611
57BRSK11.03957155
58MAP3K31.03162274
59CHUK1.02029386
60MAP4K11.01567693
61MAP3K50.99064281
62MAP3K80.95702392
63CHEK20.95521156
64EIF2AK20.94195100
65AURKA0.93778556
66CDK190.93082626
67CDK60.92793794
68STK30.92311573
69TEC0.89938595
70CDK80.89376678
71CHEK10.89353555
72ALK0.87203624
73TAOK20.86243052
74TGFBR10.84695680
75EPHA20.79573839
76MAP3K110.79424890
77CSK0.78795922
78ATM0.78561334
79MELK0.78057354
80BTK0.77935955
81STK240.76931052
82ZAK0.75810676
83SIK30.75777487
84MAP3K100.73789747
85MAPK150.73160420
86CDK20.73124834
87PINK10.73023045
88STK40.72376521
89STK160.69786444
90CDK30.69224371
91IKBKE0.67563109
92CSNK2A10.66014818
93YES10.65690074
94CSNK1G10.65439325
95DMPK0.65430603
96PAK40.64974840
97TRPM70.64324786
98NUAK10.61477040
99FGFR10.60912968
100PBK0.60740006
101RPS6KA50.60429706
102MOS0.59172244
103CSNK2A20.57501363
104TBK10.57438033
105BRAF0.56248126
106SCYL20.54785267
107TGFBR20.53192190
108BRD40.52349171
109DYRK1B0.51979020
110ZAP700.51674283
111MARK30.51116412
112PLK20.50580069
113PIK3CG0.48815226
114RPS6KA60.48279841
115MAPK70.48104659
116LATS10.47428916
117MAPKAPK20.46273747
118STK38L0.45746710
119RPS6KL10.44865880
120RPS6KC10.44865880
121CSNK1E0.44599245
122TESK10.44524370
123CDK10.44368760
124FGR0.43977847
125PAK10.40041860
126DYRK20.38279672
127CDK90.34985496
128CSNK1A1L0.31884456
129KSR10.29461519
130LATS20.27690624
131IRAK10.25952556
132CSNK1G30.25017813

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.73052756
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.31973821
3Mismatch repair_Homo sapiens_hsa034303.25388798
4* Spliceosome_Homo sapiens_hsa030402.92259462
5Base excision repair_Homo sapiens_hsa034102.80656045
6RNA transport_Homo sapiens_hsa030132.67331661
7RNA polymerase_Homo sapiens_hsa030202.63826106
8Ribosome_Homo sapiens_hsa030102.51558040
9Homologous recombination_Homo sapiens_hsa034402.46724298
10Nucleotide excision repair_Homo sapiens_hsa034202.36047097
11Cell cycle_Homo sapiens_hsa041102.36012936
12Basal transcription factors_Homo sapiens_hsa030222.09132434
13Proteasome_Homo sapiens_hsa030502.06298587
14Fanconi anemia pathway_Homo sapiens_hsa034601.94757917
15mRNA surveillance pathway_Homo sapiens_hsa030151.83914507
16One carbon pool by folate_Homo sapiens_hsa006701.83221554
17Pyrimidine metabolism_Homo sapiens_hsa002401.81172999
18RNA degradation_Homo sapiens_hsa030181.80950889
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.77510095
20p53 signaling pathway_Homo sapiens_hsa041151.72068060
21Herpes simplex infection_Homo sapiens_hsa051681.60634085
22Non-homologous end-joining_Homo sapiens_hsa034501.53362537
23NF-kappa B signaling pathway_Homo sapiens_hsa040641.36799934
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.33780624
25Epstein-Barr virus infection_Homo sapiens_hsa051691.29430778
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.27185627
27Legionellosis_Homo sapiens_hsa051341.27014436
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.26358252
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.23448371
30Antigen processing and presentation_Homo sapiens_hsa046121.20615172
31Measles_Homo sapiens_hsa051621.19987163
32Protein export_Homo sapiens_hsa030601.15231701
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.11321610
34Graft-versus-host disease_Homo sapiens_hsa053321.10819445
35Parkinsons disease_Homo sapiens_hsa050121.10212630
36Primary immunodeficiency_Homo sapiens_hsa053401.09902647
37NOD-like receptor signaling pathway_Homo sapiens_hsa046211.08729921
38Allograft rejection_Homo sapiens_hsa053301.01006031
39Thyroid cancer_Homo sapiens_hsa052160.98351070
40HTLV-I infection_Homo sapiens_hsa051660.97865295
41Transcriptional misregulation in cancer_Homo sapiens_hsa052020.97085251
42Oxidative phosphorylation_Homo sapiens_hsa001900.95571111
43Leishmaniasis_Homo sapiens_hsa051400.95367677
44Regulation of autophagy_Homo sapiens_hsa041400.92408532
45Shigellosis_Homo sapiens_hsa051310.91741397
46Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.91067457
47Apoptosis_Homo sapiens_hsa042100.90756260
48Viral carcinogenesis_Homo sapiens_hsa052030.89579136
49Acute myeloid leukemia_Homo sapiens_hsa052210.89394637
50Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.88904353
51MicroRNAs in cancer_Homo sapiens_hsa052060.87525836
52SNARE interactions in vesicular transport_Homo sapiens_hsa041300.87466092
53Purine metabolism_Homo sapiens_hsa002300.86671809
54RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.86514816
55Intestinal immune network for IgA production_Homo sapiens_hsa046720.85880721
56Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.82991485
57Hepatitis B_Homo sapiens_hsa051610.82629394
58Influenza A_Homo sapiens_hsa051640.81421857
59Small cell lung cancer_Homo sapiens_hsa052220.81087188
60Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.80559487
61B cell receptor signaling pathway_Homo sapiens_hsa046620.79239499
62TGF-beta signaling pathway_Homo sapiens_hsa043500.78787318
63Huntingtons disease_Homo sapiens_hsa050160.78331854
64Chronic myeloid leukemia_Homo sapiens_hsa052200.72258054
65Notch signaling pathway_Homo sapiens_hsa043300.71376067
66Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.69031915
67Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.67711915
68Jak-STAT signaling pathway_Homo sapiens_hsa046300.66841723
69T cell receptor signaling pathway_Homo sapiens_hsa046600.65725244
70TNF signaling pathway_Homo sapiens_hsa046680.65325551
71Prostate cancer_Homo sapiens_hsa052150.64911921
72Hippo signaling pathway_Homo sapiens_hsa043900.64479199
73Hematopoietic cell lineage_Homo sapiens_hsa046400.64254395
74Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.63643527
75Toll-like receptor signaling pathway_Homo sapiens_hsa046200.61938044
76Osteoclast differentiation_Homo sapiens_hsa043800.59303644
77Malaria_Homo sapiens_hsa051440.59112665
78Oocyte meiosis_Homo sapiens_hsa041140.58054893
79Colorectal cancer_Homo sapiens_hsa052100.57853330
80Type I diabetes mellitus_Homo sapiens_hsa049400.57001113
81Viral myocarditis_Homo sapiens_hsa054160.56737569
82Hedgehog signaling pathway_Homo sapiens_hsa043400.56489207
83Adherens junction_Homo sapiens_hsa045200.56283530
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55314716
85Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54435626
86Autoimmune thyroid disease_Homo sapiens_hsa053200.51994866
87Alzheimers disease_Homo sapiens_hsa050100.51447209
88Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.50991949
89Melanoma_Homo sapiens_hsa052180.50377628
90Pancreatic cancer_Homo sapiens_hsa052120.50102420
91AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.49174181
92Asthma_Homo sapiens_hsa053100.48982850
93Steroid biosynthesis_Homo sapiens_hsa001000.48651082
94Arachidonic acid metabolism_Homo sapiens_hsa005900.47594311
95Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47302134
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47095745
97Folate biosynthesis_Homo sapiens_hsa007900.47088413
98Toxoplasmosis_Homo sapiens_hsa051450.46708061
99Basal cell carcinoma_Homo sapiens_hsa052170.45998612
100Leukocyte transendothelial migration_Homo sapiens_hsa046700.45902899
101Sulfur relay system_Homo sapiens_hsa041220.45845689
102FoxO signaling pathway_Homo sapiens_hsa040680.44963855
103Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.43924476
104Pathways in cancer_Homo sapiens_hsa052000.43344977
105Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42448546
106Selenocompound metabolism_Homo sapiens_hsa004500.41399980
107Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.40994455
108Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.39430367
109Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.38862763
110Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.38081210
111Pertussis_Homo sapiens_hsa051330.37056221
112Circadian rhythm_Homo sapiens_hsa047100.36437797
113Prolactin signaling pathway_Homo sapiens_hsa049170.36279995
114Bladder cancer_Homo sapiens_hsa052190.35308820
115Wnt signaling pathway_Homo sapiens_hsa043100.34861821
116Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.34013338
117Tuberculosis_Homo sapiens_hsa051520.33303684
118Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.32693613
119Hepatitis C_Homo sapiens_hsa051600.32656491
120Salmonella infection_Homo sapiens_hsa051320.32349766
121Propanoate metabolism_Homo sapiens_hsa006400.26613044
122African trypanosomiasis_Homo sapiens_hsa051430.20044718
123Renal cell carcinoma_Homo sapiens_hsa052110.16925668
124MAPK signaling pathway_Homo sapiens_hsa040100.16291159
125Dorso-ventral axis formation_Homo sapiens_hsa043200.15855952
126Metabolic pathways_Homo sapiens_hsa011000.14003300
127Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.12146515
128Phototransduction_Homo sapiens_hsa047440.11726838
129Long-term depression_Homo sapiens_hsa047300.11414099
130Peroxisome_Homo sapiens_hsa041460.09001834
131Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.08832014
132Non-small cell lung cancer_Homo sapiens_hsa052230.08311284
133Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.07190433
134Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.06868910
135Fatty acid elongation_Homo sapiens_hsa000620.05401039
136alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.04848438

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