SMO

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a G protein-coupled receptor that interacts with the patched protein, a receptor for hedgehog proteins. The encoded protein tranduces signals to other proteins after activation by a hedgehog protein/patched protein complex. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chondrocyte proliferation (GO:0035988)6.16033538
2paraxial mesoderm development (GO:0048339)4.80065476
3epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)4.56106950
4lens fiber cell development (GO:0070307)4.48801048
5cell migration involved in heart development (GO:0060973)4.43750077
6planar cell polarity pathway involved in neural tube closure (GO:0090179)4.36673004
7lung epithelium development (GO:0060428)4.32557809
8negative regulation of chondrocyte differentiation (GO:0032331)4.31527215
9regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.15140238
10endocardial cushion morphogenesis (GO:0003203)4.13428579
11epithelial cell fate commitment (GO:0072148)4.09272781
12mesenchyme morphogenesis (GO:0072132)3.95765236
13L-serine metabolic process (GO:0006563)3.87593832
14collecting duct development (GO:0072044)3.85624622
15G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.82041821
16positive regulation of epithelial to mesenchymal transition (GO:0010718)3.75862430
17outer ear morphogenesis (GO:0042473)3.71591668
18regulation of posttranscriptional gene silencing (GO:0060147)3.69741157
19regulation of gene silencing by miRNA (GO:0060964)3.69741157
20regulation of gene silencing by RNA (GO:0060966)3.69741157
21heart valve formation (GO:0003188)3.67892585
22epithelial cell differentiation involved in prostate gland development (GO:0060742)3.58147928
23regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.57487127
24protein heterotrimerization (GO:0070208)3.51669804
25hippo signaling (GO:0035329)3.51021996
26negative regulation of cartilage development (GO:0061037)3.47390276
27bone trabecula formation (GO:0060346)3.36185762
28Notch signaling involved in heart development (GO:0061314)3.35656254
29regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901213.34581414
30atrioventricular valve morphogenesis (GO:0003181)3.32716774
31notochord development (GO:0030903)3.28853757
32anatomical structure regression (GO:0060033)3.25385560
33pre-miRNA processing (GO:0031054)3.24159504
34collagen fibril organization (GO:0030199)3.23966412
35DNA unwinding involved in DNA replication (GO:0006268)3.22565567
36viral transcription (GO:0019083)3.21634245
37embryonic foregut morphogenesis (GO:0048617)3.19861409
38regulation of hippo signaling (GO:0035330)3.18958862
39cell proliferation involved in metanephros development (GO:0072203)3.18270211
40cell surface receptor signaling pathway involved in heart development (GO:0061311)3.18229008
41regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.16466728
42hindlimb morphogenesis (GO:0035137)3.15479313
43somatic stem cell division (GO:0048103)3.14232752
44protein-DNA complex disassembly (GO:0032986)3.11686604
45nucleosome disassembly (GO:0006337)3.11686604
46lateral sprouting from an epithelium (GO:0060601)3.11043132
47regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)3.09578770
48lung-associated mesenchyme development (GO:0060484)3.08832164
49branching involved in salivary gland morphogenesis (GO:0060445)3.05913298
50bone morphogenesis (GO:0060349)3.04879017
51translational termination (GO:0006415)3.03298348
52Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.02166919
53regulation of non-canonical Wnt signaling pathway (GO:2000050)3.01907562
54coronary vasculature morphogenesis (GO:0060977)3.00333431
55regulation of cell fate specification (GO:0042659)2.98690569
56glucocorticoid receptor signaling pathway (GO:0042921)2.98126638
57regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.97024320
58regulation of establishment of planar polarity (GO:0090175)2.94908109
59polarized epithelial cell differentiation (GO:0030859)2.93964242
60embryonic hindlimb morphogenesis (GO:0035116)2.92866427
61cochlea morphogenesis (GO:0090103)2.90761294
62regulation of cardioblast differentiation (GO:0051890)2.89749631
63venous blood vessel morphogenesis (GO:0048845)2.86093583
64mesenchymal cell proliferation (GO:0010463)2.84609540
65heterochromatin organization (GO:0070828)2.84570120
66embryonic cranial skeleton morphogenesis (GO:0048701)2.83181099
67* mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.83042684
68respiratory tube development (GO:0030323)2.81967479
69negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.80988690
70positive regulation of stem cell differentiation (GO:2000738)2.80016260
71positive regulation of BMP signaling pathway (GO:0030513)2.79735617
72non-canonical Wnt signaling pathway (GO:0035567)2.77804624
73embryonic skeletal joint morphogenesis (GO:0060272)2.77453640
74serine family amino acid biosynthetic process (GO:0009070)2.77223911
75ribosomal small subunit biogenesis (GO:0042274)2.77165844
76regulation of cartilage development (GO:0061035)2.76989210
77histone arginine methylation (GO:0034969)2.76849216
78regulation of chondrocyte differentiation (GO:0032330)2.76743307
79ribosomal small subunit assembly (GO:0000028)2.75688832
80establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.75209949
81camera-type eye morphogenesis (GO:0048593)2.74449422
82negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.73228251
83negative regulation of cell fate specification (GO:0009996)2.73053100
84mesenchyme development (GO:0060485)2.72741633
85metanephric mesenchyme development (GO:0072075)2.71781561
86cardiac muscle cell proliferation (GO:0060038)2.69763442
87apoptotic process involved in morphogenesis (GO:0060561)2.69159215
88regulation of transforming growth factor beta2 production (GO:0032909)2.68536603
89digestive tract morphogenesis (GO:0048546)2.67352547
90glomerular basement membrane development (GO:0032836)2.67189831
91glycine metabolic process (GO:0006544)2.66817690
92regulation of somitogenesis (GO:0014807)2.66201369
93* regulation of heart morphogenesis (GO:2000826)2.65910140
94kidney mesenchyme development (GO:0072074)2.65824193
95negative regulation of smoothened signaling pathway (GO:0045879)2.65305214
96mesenchymal-epithelial cell signaling (GO:0060638)2.64896652
97regulation of catenin import into nucleus (GO:0035412)2.64451026
98endodermal cell differentiation (GO:0035987)2.64447254
99protein complex localization (GO:0031503)2.62719155
100nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.62129559
101regulation of extracellular matrix organization (GO:1903053)2.61855469
102negative regulation of glial cell proliferation (GO:0060253)2.61541997
103pattern specification involved in kidney development (GO:0061004)2.60775566
104lens morphogenesis in camera-type eye (GO:0002089)2.60216926
105cardiac epithelial to mesenchymal transition (GO:0060317)2.59610257
106positive regulation of extracellular matrix organization (GO:1903055)2.59440023
107negative regulation of DNA repair (GO:0045738)2.57339478
108positive regulation of catenin import into nucleus (GO:0035413)2.57027387
109craniofacial suture morphogenesis (GO:0097094)2.56553915
110dorsal/ventral axis specification (GO:0009950)2.56316679
111radial glial cell differentiation (GO:0060019)2.55953008
112positive regulation of SMAD protein import into nucleus (GO:0060391)2.55563596
113neural tube development (GO:0021915)2.55286113
114DNA strand renaturation (GO:0000733)2.55065690
115neuronal stem cell maintenance (GO:0097150)2.53555179
116mitotic chromosome condensation (GO:0007076)2.53420258
117middle ear morphogenesis (GO:0042474)2.52896988
118cartilage morphogenesis (GO:0060536)2.52665636
119* positive regulation of mesenchymal cell proliferation (GO:0002053)2.51704177
120peptidyl-arginine omega-N-methylation (GO:0035247)2.51009813
121tooth mineralization (GO:0034505)2.50898293
122epithelial to mesenchymal transition (GO:0001837)2.50686134
123mesenchymal cell development (GO:0014031)2.50369087
124insulin-like growth factor receptor signaling pathway (GO:0048009)2.49762022
125convergent extension (GO:0060026)2.49413313
126gastrulation with mouth forming second (GO:0001702)2.49197862
127translational elongation (GO:0006414)2.49055815
128chromatin assembly (GO:0031497)2.48867470
129midbrain development (GO:0030901)2.48771333
130DNA strand elongation involved in DNA replication (GO:0006271)2.48574766
131establishment or maintenance of monopolar cell polarity (GO:0061339)2.47860487
132establishment of monopolar cell polarity (GO:0061162)2.47860487
133heart valve morphogenesis (GO:0003179)2.47186208
134regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.46980747
135nephron tubule development (GO:0072080)2.46928233
136establishment of tissue polarity (GO:0007164)2.46601049
137* neuron projection extension involved in neuron projection guidance (GO:1902284)2.46164601
138* axon extension involved in axon guidance (GO:0048846)2.46164601
139tongue development (GO:0043586)2.45775664
140establishment of apical/basal cell polarity (GO:0035089)2.45385043
141post-anal tail morphogenesis (GO:0036342)2.45324151
142serine family amino acid catabolic process (GO:0009071)2.44359590
143establishment of planar polarity (GO:0001736)2.43259347
144SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.39323537
145axis elongation (GO:0003401)2.38490199
146negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.36868443
147establishment or maintenance of bipolar cell polarity (GO:0061245)2.36646365
148establishment or maintenance of apical/basal cell polarity (GO:0035088)2.36646365
149generation of neurons (GO:0048699)2.36406733
150protein complex disassembly (GO:0043241)2.36404326
151prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.36111433
152protein localization to kinetochore (GO:0034501)2.35886396
153DNA strand elongation (GO:0022616)2.35230469
154establishment of integrated proviral latency (GO:0075713)2.34316126
155cotranslational protein targeting to membrane (GO:0006613)2.33950813
156maturation of SSU-rRNA (GO:0030490)2.33201717
157protein targeting to ER (GO:0045047)2.30291242
158cellular protein complex disassembly (GO:0043624)2.26199118
159DNA replication initiation (GO:0006270)2.26189587
160viral life cycle (GO:0019058)2.26037841
161peptidyl-arginine methylation (GO:0018216)2.25650609
162peptidyl-arginine N-methylation (GO:0035246)2.25650609
163regulation of mammary gland epithelial cell proliferation (GO:0033599)2.25155774
164anterior/posterior axis specification, embryo (GO:0008595)2.24264044
165negative regulation of catenin import into nucleus (GO:0035414)2.22183628
166ventricular cardiac muscle cell development (GO:0055015)2.22066051
167neural tube closure (GO:0001843)2.21768617
168tube closure (GO:0060606)2.21168705
169* positive regulation of smoothened signaling pathway (GO:0045880)2.19495447
170establishment of protein localization to endoplasmic reticulum (GO:0072599)2.19409014
171positive regulation of cell cycle G2/M phase transition (GO:1902751)2.18390715
172positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.18390715

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.57578350
2E2F7_22180533_ChIP-Seq_HELA_Human6.30881497
3FOXM1_23109430_ChIP-Seq_U2OS_Human5.39440094
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.79155864
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.48278496
6TP63_19390658_ChIP-ChIP_HaCaT_Human3.08185140
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.70549050
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.67138425
9RBPJ_22232070_ChIP-Seq_NCS_Mouse2.65797824
10AR_21909140_ChIP-Seq_LNCAP_Human2.64667047
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.49150427
12RARG_19884340_ChIP-ChIP_MEFs_Mouse2.47828402
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.44649556
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.41277215
15EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.31637616
16CLOCK_20551151_ChIP-Seq_293T_Human2.27557352
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.23045004
18ERG_21242973_ChIP-ChIP_JURKAT_Human2.12530115
19* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.12307109
20RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.10272825
21KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.06104784
22KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.06104784
23KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.06104784
24ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.03381297
25EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.03280477
26MYC_22102868_ChIP-Seq_BL_Human2.00009397
27* TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.87605693
28STAT6_21828071_ChIP-Seq_BEAS2B_Human1.85546708
29ELK3_25401928_ChIP-Seq_HUVEC_Human1.83963497
30MYC_19079543_ChIP-ChIP_MESCs_Mouse1.80783350
31HIF1A_21447827_ChIP-Seq_MCF-7_Human1.78810979
32* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.76625402
33TP53_20018659_ChIP-ChIP_R1E_Mouse1.69471045
34DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.68024314
35KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.66298780
36ZFP281_18757296_ChIP-ChIP_E14_Mouse1.66251605
37POU5F1_16153702_ChIP-ChIP_HESCs_Human1.65871641
38HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.63934791
39* ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.63184162
40EZH2_27304074_Chip-Seq_ESCs_Mouse1.63140841
41MYC_18358816_ChIP-ChIP_MESCs_Mouse1.61811825
42* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.60996716
43E2F1_21310950_ChIP-Seq_MCF-7_Human1.60322862
44NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.60009824
45ESR1_15608294_ChIP-ChIP_MCF-7_Human1.56841607
46BRD4_25478319_ChIP-Seq_HGPS_Human1.56615802
47XRN2_22483619_ChIP-Seq_HELA_Human1.54629795
48TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.53906103
49ZFP281_27345836_Chip-Seq_ESCs_Mouse1.52824370
50PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.52717158
51CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.52008939
52* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.48939310
53* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.48939310
54KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.48222432
55TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47651159
56NANOG_18555785_ChIP-Seq_MESCs_Mouse1.46276467
57KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.45116197
58POU5F1_16518401_ChIP-PET_MESCs_Mouse1.43274229
59TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.43114854
60WT1_19549856_ChIP-ChIP_CCG9911_Human1.42042197
61CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.41349197
62VDR_21846776_ChIP-Seq_THP-1_Human1.39931483
63THAP11_20581084_ChIP-Seq_MESCs_Mouse1.39904284
64NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.37419760
65TCF3_18692474_ChIP-Seq_MEFs_Mouse1.36703317
66P300_27058665_Chip-Seq_ZR-75-30cells_Human1.33888683
67* KDM2B_26808549_Chip-Seq_K562_Human1.33383793
68NELFA_20434984_ChIP-Seq_ESCs_Mouse1.33301022
69TCF3_18692474_ChIP-Seq_MESCs_Mouse1.31731900
70ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.31461236
71SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.30957259
72RING1B_27294783_Chip-Seq_NPCs_Mouse1.29862540
73UBF1/2_26484160_Chip-Seq_HMECs_Human1.28330749
74CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.27732636
75ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.27115488
76LXR_22292898_ChIP-Seq_THP-1_Human1.26635790
77ISL1_27105846_Chip-Seq_CPCs_Mouse1.26242716
78MYC_19030024_ChIP-ChIP_MESCs_Mouse1.25051203
79CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.24831807
80POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.23924992
81NANOG_16153702_ChIP-ChIP_HESCs_Human1.23189251
82OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.22742507
83SOX2_18692474_ChIP-Seq_MEFs_Mouse1.21746954
84KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.20744012
85* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.20148252
86MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.19199394
87CTCF_27219007_Chip-Seq_Bcells_Human1.18368336
88EZH2_22144423_ChIP-Seq_EOC_Human1.17357085
89ATF3_27146783_Chip-Seq_COLON_Human1.16523628
90SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.15754715
91POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.14702801
92POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.14507512
93* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.14360480
94RACK7_27058665_Chip-Seq_MCF-7_Human1.14155625
95* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.13898665
96TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.13350472
97* TET1_21451524_ChIP-Seq_MESCs_Mouse1.12887990
98OCT4_18692474_ChIP-Seq_MEFs_Mouse1.12659866
99TTF2_22483619_ChIP-Seq_HELA_Human1.12553981
100TP53_22127205_ChIP-Seq_IMR90_Human1.12360634
101UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.12290884
102NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.11284219
103SOX2_18692474_ChIP-Seq_MESCs_Mouse1.11210924
104CBX2_27304074_Chip-Seq_ESCs_Mouse1.11205651
105* TCF7_22412390_ChIP-Seq_EML_Mouse1.10929898
106ZNF263_19887448_ChIP-Seq_K562_Human1.10661377
107SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.10149815
108KDM2B_26808549_Chip-Seq_DND41_Human1.09997547
109* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.09308892
110RING1B_27294783_Chip-Seq_ESCs_Mouse1.08739687
111SOX3_22085726_ChIP-Seq_NPCs_Mouse1.08698806
112* RNF2_27304074_Chip-Seq_ESCs_Mouse1.08527810
113KDM2B_26808549_Chip-Seq_JURKAT_Human1.07727371
114* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.07168962
115NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.06911665
116* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.06446087
117NFIB_24661679_ChIP-Seq_LUNG_Mouse1.05946777
118ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.05751051
119JARID2_20064375_ChIP-Seq_MESCs_Mouse1.04992519
120SALL1_21062744_ChIP-ChIP_HESCs_Human1.04308099
121MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.04065891
122SOX9_24532713_ChIP-Seq_HFSC_Mouse1.04028186
123CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.03937984
124DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.03389234
125NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.03185173
126SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.03140279
127SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.03140279
128NANOG_21062744_ChIP-ChIP_HESCs_Human1.02977230
129* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.02220242
130EED_16625203_ChIP-ChIP_MESCs_Mouse1.02095953
131ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.01425976
132ESR1_21235772_ChIP-Seq_MCF-7_Human1.01281569
133MYCN_18555785_ChIP-Seq_MESCs_Mouse1.01142245
134NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.00764808
135SOX2_16153702_ChIP-ChIP_HESCs_Human1.00530351
136KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.00382684
137SOX2_18555785_ChIP-Seq_MESCs_Mouse1.00366412
138CHD1_26751641_Chip-Seq_LNCaP_Human1.00157233
139ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.96052097
140STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.95927443
141KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.94775446
142SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.94481330
143KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.93878944
144TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.92735325
145EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.91061822
146SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.88185377
147FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.87692719
148PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.87038329

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis4.67709700
2MP0008438_abnormal_cutaneous_collagen3.73148649
3* MP0010030_abnormal_orbit_morphology3.38914691
4MP0003705_abnormal_hypodermis_morpholog3.16584258
5MP0005503_abnormal_tendon_morphology2.84641063
6MP0009053_abnormal_anal_canal2.57127451
7MP0006292_abnormal_olfactory_placode2.56110408
8MP0000537_abnormal_urethra_morphology2.43528780
9MP0005275_abnormal_skin_tensile2.41533153
10MP0001958_emphysema2.31760240
11MP0003941_abnormal_skin_development2.29553267
12MP0005257_abnormal_intraocular_pressure2.27942172
13MP0004272_abnormal_basement_membrane2.25781503
14MP0009780_abnormal_chondrocyte_physiolo2.20307808
15MP0003385_abnormal_body_wall2.13353460
16MP0003136_yellow_coat_color2.09454499
17MP0000428_abnormal_craniofacial_morphol2.07722297
18MP0005623_abnormal_meninges_morphology1.96763120
19MP0003115_abnormal_respiratory_system1.88817012
20MP0006054_spinal_hemorrhage1.88446259
21MP0005508_abnormal_skeleton_morphology1.83090109
22MP0009379_abnormal_foot_pigmentation1.82369112
23* MP0000049_abnormal_middle_ear1.82005136
24MP0003942_abnormal_urinary_system1.80991283
25MP0002282_abnormal_trachea_morphology1.80685690
26MP0002089_abnormal_postnatal_growth/wei1.79022187
27MP0001346_abnormal_lacrimal_gland1.78405619
28* MP0002249_abnormal_larynx_morphology1.76390430
29* MP0009250_abnormal_appendicular_skeleto1.73829376
30MP0004858_abnormal_nervous_system1.73306157
31MP0003123_paternal_imprinting1.72726642
32MP0003283_abnormal_digestive_organ1.71296530
33MP0010352_gastrointestinal_tract_polyps1.68304410
34MP0009672_abnormal_birth_weight1.66702308
35MP0003878_abnormal_ear_physiology1.66295972
36MP0005377_hearing/vestibular/ear_phenot1.66295972
37MP0003279_aneurysm1.66074154
38MP0002932_abnormal_joint_morphology1.65514095
39MP0003755_abnormal_palate_morphology1.64267758
40* MP0003937_abnormal_limbs/digits/tail_de1.55130723
41MP0000733_abnormal_muscle_development1.54926688
42MP0003122_maternal_imprinting1.54617517
43MP0000534_abnormal_ureter_morphology1.52807248
44MP0004134_abnormal_chest_morphology1.52728036
45MP0009384_cardiac_valve_regurgitation1.52434378
46MP0001299_abnormal_eye_distance/1.48688002
47MP0003693_abnormal_embryo_hatching1.47847876
48MP0002254_reproductive_system_inflammat1.46676196
49MP0002938_white_spotting1.45156429
50MP0000778_abnormal_nervous_system1.44148965
51MP0005076_abnormal_cell_differentiation1.41758288
52MP0004133_heterotaxia1.41173674
53MP0002102_abnormal_ear_morphology1.38826433
54* MP0003861_abnormal_nervous_system1.38722512
55* MP0003935_abnormal_craniofacial_develop1.36275286
56MP0002234_abnormal_pharynx_morphology1.32022979
57MP0005248_abnormal_Harderian_gland1.30112895
58MP0002111_abnormal_tail_morphology1.30093643
59MP0000579_abnormal_nail_morphology1.29985222
60MP0004197_abnormal_fetal_growth/weight/1.29573165
61MP0005394_taste/olfaction_phenotype1.28780911
62MP0005499_abnormal_olfactory_system1.28780911
63MP0003890_abnormal_embryonic-extraembry1.28030370
64* MP0000163_abnormal_cartilage_morphology1.27238622
65* MP0000762_abnormal_tongue_morphology1.25657134
66MP0000462_abnormal_digestive_system1.23778406
67* MP0001293_anophthalmia1.22980898
68* MP0003938_abnormal_ear_development1.22110783
69MP0002060_abnormal_skin_morphology1.22020120
70MP0003111_abnormal_nucleus_morphology1.21416224
71* MP0000432_abnormal_head_morphology1.21305747
72MP0003121_genomic_imprinting1.21132415
73* MP0002116_abnormal_craniofacial_bone1.20001432
74MP0008007_abnormal_cellular_replicative1.18998145
75MP0005023_abnormal_wound_healing1.18580874
76* MP0002092_abnormal_eye_morphology1.17243216
77MP0003566_abnormal_cell_adhesion1.13784384
78MP0003567_abnormal_fetal_cardiomyocyte1.13050103
79MP0008789_abnormal_olfactory_epithelium1.12902349
80* MP0002109_abnormal_limb_morphology1.11690389
81MP0000678_abnormal_parathyroid_gland1.11626928
82MP0002697_abnormal_eye_size1.11268266
83* MP0002084_abnormal_developmental_patter1.11097949
84* MP0002115_abnormal_skeleton_extremities1.09803855
85* MP0002233_abnormal_nose_morphology1.09648888
86MP0000383_abnormal_hair_follicle1.08200291
87MP0009278_abnormal_bone_marrow1.08009792
88* MP0002085_abnormal_embryonic_tissue1.07604605
89MP0010368_abnormal_lymphatic_system1.06059433
90* MP0002113_abnormal_skeleton_development1.03437756
91MP0001849_ear_inflammation1.03206338
92MP0003119_abnormal_digestive_system1.02273975
93MP0004233_abnormal_muscle_weight1.01010737
94MP0002114_abnormal_axial_skeleton0.99371809
95MP0003077_abnormal_cell_cycle0.98114626
96MP0002896_abnormal_bone_mineralization0.95028982
97MP0004808_abnormal_hematopoietic_stem0.94883224
98MP0000350_abnormal_cell_proliferation0.94840244
99MP0002108_abnormal_muscle_morphology0.94359229
100MP0005197_abnormal_uvea_morphology0.94266637
101MP0009703_decreased_birth_body0.94175125
102MP0000467_abnormal_esophagus_morphology0.93058471
103MP0010094_abnormal_chromosome_stability0.92615249
104* MP0001286_abnormal_eye_development0.89150195
105* MP0002925_abnormal_cardiovascular_devel0.88316223
106MP0002653_abnormal_ependyma_morphology0.88108321
107MP0001730_embryonic_growth_arrest0.88068167
108* MP0008932_abnormal_embryonic_tissue0.88015116
109* MP0002081_perinatal_lethality0.86752189
110MP0010678_abnormal_skin_adnexa0.86237746
111* MP0003984_embryonic_growth_retardation0.85968451
112* MP0002088_abnormal_embryonic_growth/wei0.85934548
113* MP0001672_abnormal_embryogenesis/_devel0.85589934
114* MP0005380_embryogenesis_phenotype0.85589934
115MP0003091_abnormal_cell_migration0.84626277
116* MP0001697_abnormal_embryo_size0.83550282
117* MP0002086_abnormal_extraembryonic_tissu0.82975341
118MP0000647_abnormal_sebaceous_gland0.82679691
119MP0004957_abnormal_blastocyst_morpholog0.82329191
120MP0000377_abnormal_hair_follicle0.81535863
121MP0000767_abnormal_smooth_muscle0.81230000
122MP0001270_distended_abdomen0.81065743
123MP0000026_abnormal_inner_ear0.79917518
124MP0001340_abnormal_eyelid_morphology0.78003219
125MP0000631_abnormal_neuroendocrine_gland0.77970277
126MP0003315_abnormal_perineum_morphology0.75098755
127MP0002396_abnormal_hematopoietic_system0.74969322
128* MP0002152_abnormal_brain_morphology0.74794342
129MP0002177_abnormal_outer_ear0.73883632
130MP0010630_abnormal_cardiac_muscle0.73560164

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.32185342
2Neonatal short-limb short stature (HP:0008921)5.23560000
3Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.72797850
4Short 4th metacarpal (HP:0010044)3.72797850
5Premature rupture of membranes (HP:0001788)3.71876312
6Coronal craniosynostosis (HP:0004440)3.68914698
7Shallow orbits (HP:0000586)3.63518175
8Turricephaly (HP:0000262)3.52793793
9Ankle contracture (HP:0006466)3.36964002
10Partial duplication of the phalanx of hand (HP:0009999)3.12070954
11Vitreoretinal degeneration (HP:0000655)3.02959828
12Abnormality of the 4th metacarpal (HP:0010012)3.02592250
13Aortic dissection (HP:0002647)2.90162845
14Aplasia involving bones of the extremities (HP:0009825)2.89893968
15Aplasia involving bones of the upper limbs (HP:0009823)2.89893968
16Aplasia of the phalanges of the hand (HP:0009802)2.89893968
17Septo-optic dysplasia (HP:0100842)2.89778606
18Deviation of the hallux (HP:0010051)2.84857477
19High anterior hairline (HP:0009890)2.78023589
20Hallux valgus (HP:0001822)2.76440360
21Aortic aneurysm (HP:0004942)2.76247535
22Partial duplication of thumb phalanx (HP:0009944)2.75854515
23Bladder diverticulum (HP:0000015)2.63728853
24Atrophic scars (HP:0001075)2.60663127
25Abnormality of the aortic arch (HP:0012303)2.60374791
26Renal duplication (HP:0000075)2.58716441
27Choanal stenosis (HP:0000452)2.58353270
28Hepatoblastoma (HP:0002884)2.57735089
29Broad metatarsal (HP:0001783)2.56756714
30Abnormality of the middle phalanges of the toes (HP:0010183)2.53438930
31Broad toe (HP:0001837)2.53423446
32Maternal diabetes (HP:0009800)2.52314040
33Mitral valve prolapse (HP:0001634)2.47033741
34Increased nuchal translucency (HP:0010880)2.46255569
35Broad hallux (HP:0010055)2.42902971
36Soft skin (HP:0000977)2.42223174
37Broad phalanges of the hand (HP:0009768)2.41515814
38Camptodactyly of toe (HP:0001836)2.40943052
39Bronchomalacia (HP:0002780)2.40323956
40Selective tooth agenesis (HP:0001592)2.37011761
41Colon cancer (HP:0003003)2.36966299
42Cutaneous syndactyly (HP:0012725)2.35900796
43Anophthalmia (HP:0000528)2.35077254
44Broad finger (HP:0001500)2.34979163
45Reticulocytopenia (HP:0001896)2.31043492
46Ulnar bowing (HP:0003031)2.28593684
47Infantile muscular hypotonia (HP:0008947)2.28416250
48Cutaneous finger syndactyly (HP:0010554)2.25062955
49Broad phalanx (HP:0006009)2.22010540
50Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.21844656
51Abnormal ventriculo-arterial connection (HP:0011563)2.21126788
52Transposition of the great arteries (HP:0001669)2.21126788
53Abnormal connection of the cardiac segments (HP:0011545)2.21126788
54Cerebral aneurysm (HP:0004944)2.17879602
55Germ cell neoplasia (HP:0100728)2.16935908
56Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.16351021
57Abnormality of the calcaneus (HP:0008364)2.14137231
58Abnormality of dentin (HP:0010299)2.13765434
59Alacrima (HP:0000522)2.12999043
60Overriding aorta (HP:0002623)2.11025343
61Synostosis of carpal bones (HP:0005048)2.10248997
62Dilatation of the ascending aorta (HP:0005111)2.08691165
63Thin ribs (HP:0000883)2.08654994
64Follicular hyperkeratosis (HP:0007502)2.08078923
65Broad distal phalanx of finger (HP:0009836)2.06651144
66Mesomelia (HP:0003027)2.06628766
67Bilateral microphthalmos (HP:0007633)2.06144320
68Double outlet right ventricle (HP:0001719)2.03165938
69Congenital malformation of the right heart (HP:0011723)2.03165938
70Fragile skin (HP:0001030)2.01402102
71Genu recurvatum (HP:0002816)2.01178880
72Abnormality of the distal phalanx of the thumb (HP:0009617)2.00196473
73Skull defect (HP:0001362)2.00014131
74Preaxial foot polydactyly (HP:0001841)1.99841190
75Bowel diverticulosis (HP:0005222)1.98862963
76Trigonocephaly (HP:0000243)1.98181829
77Esophageal atresia (HP:0002032)1.96527652
78Atresia of the external auditory canal (HP:0000413)1.96303013
79Midline defect of the nose (HP:0004122)1.95648900
80Abnormality of cochlea (HP:0000375)1.94842969
81Asymmetry of the thorax (HP:0001555)1.93476824
82Limited elbow extension (HP:0001377)1.93282885
83Tarsal synostosis (HP:0008368)1.92659151
84Vascular tortuosity (HP:0004948)1.92304789
85Aplasia cutis congenita (HP:0001057)1.91849026
86Exostoses (HP:0100777)1.91739169
87Syringomyelia (HP:0003396)1.91676942
88Spinal cord lesions (HP:0100561)1.91676942
89Arterial tortuosity (HP:0005116)1.90602782
90Abnormality of the antihelix (HP:0009738)1.89463552
91Bicuspid aortic valve (HP:0001647)1.89250540
92Rectal prolapse (HP:0002035)1.88896429
93Flexion contracture of toe (HP:0005830)1.88812283
94Joint contractures involving the joints of the feet (HP:0100492)1.88812283
95Duplication of thumb phalanx (HP:0009942)1.85444016
96Broad palm (HP:0001169)1.85088557
97Arnold-Chiari malformation (HP:0002308)1.84181800
98Vaginal fistula (HP:0004320)1.83903139
99Spastic diplegia (HP:0001264)1.83556089
100Abnormality of the nasolacrimal system (HP:0000614)1.83267586
101Periauricular skin pits (HP:0100277)1.83263272
102Preauricular pit (HP:0004467)1.83263272
103Recurrent corneal erosions (HP:0000495)1.83203201
104Short middle phalanx of finger (HP:0005819)1.82321947
105Absent epiphyses (HP:0010577)1.80827088
106Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.80827088
107Broad thumb (HP:0011304)1.79787479
108Morphological abnormality of the inner ear (HP:0011390)1.79479856
109Osteoarthritis (HP:0002758)1.78586551
110Wide anterior fontanel (HP:0000260)1.78286938
111Abnormality of the lacrimal duct (HP:0011481)1.78179077
112Megalencephaly (HP:0001355)1.77994583
113Wrist flexion contracture (HP:0001239)1.77688097
114Abnormality of the phalanges of the hallux (HP:0010057)1.77609014
115Nasolacrimal duct obstruction (HP:0000579)1.77347798
116Cervical subluxation (HP:0003308)1.76851605
117Rhizomelia (HP:0008905)1.76391450
118Abnormality of the diencephalon (HP:0010662)1.76139403
119Blue sclerae (HP:0000592)1.76119497
120Abnormal number of incisors (HP:0011064)1.75783689
121Synostosis involving bones of the lower limbs (HP:0009138)1.75707216
122Synostosis involving bones of the feet (HP:0009140)1.75707216
123Hyperextensible skin (HP:0000974)1.75478638
124Deviation of the thumb (HP:0009603)1.75186445
125Abnormality of the right ventricle (HP:0001707)1.75152549
126Type 1 muscle fiber predominance (HP:0003803)1.75129922
127Spinal rigidity (HP:0003306)1.74681662
128Calcaneovalgus deformity (HP:0001848)1.74452688
129Broad long bones (HP:0005622)1.74046382
130Disproportionate tall stature (HP:0001519)1.73473987
131Renovascular hypertension (HP:0100817)1.73240815
132Aplasia/Hypoplasia of the breasts (HP:0010311)1.73160447
133Abnormality of the parietal bone (HP:0002696)1.73015682
134Metaphyseal cupping (HP:0003021)1.72694983
135Peritonitis (HP:0002586)1.72649830
136Carpal synostosis (HP:0009702)1.72567324
137Aneurysm (HP:0002617)1.72354831
138Hyperacusis (HP:0010780)1.72339529
139Intestinal fistula (HP:0100819)1.71929202
140Lymphangioma (HP:0100764)1.71492788
141Heterotopia (HP:0002282)1.71100903
142Biconcave vertebral bodies (HP:0004586)1.70887200
143Increased number of teeth (HP:0011069)1.70658566
144Rectovaginal fistula (HP:0000143)1.70610233
145Rectal fistula (HP:0100590)1.70610233
146Morphological abnormality of the middle ear (HP:0008609)1.70100172
147Limited hip movement (HP:0008800)1.69991452
148Missing ribs (HP:0000921)1.69974741
149Pterygium (HP:0001059)1.69602208
150Mitral regurgitation (HP:0001653)1.69583511
151Proximal placement of thumb (HP:0009623)1.68358682
152Rib fusion (HP:0000902)1.68345934
153Renal dysplasia (HP:0000110)1.68006832
154Neonatal death (HP:0003811)1.67838177
155Ectopic kidney (HP:0000086)1.66270374
156Irregular epiphyses (HP:0010582)1.66053911
157Myelomeningocele (HP:0002475)1.65541329
158Elfin facies (HP:0004428)1.65415929
159Midface retrusion (HP:0011800)1.63623450
160Anal stenosis (HP:0002025)1.63456028
161Omphalocele (HP:0001539)1.60990315
162Bifid tongue (HP:0010297)1.60559000

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.74549894
2SMG14.05942393
3VRK23.60230213
4TRIB33.46551300
5EEF2K3.25486587
6TAF13.10038898
7PKN22.89190941
8LATS12.84990295
9MAP3K102.77570459
10DDR22.71008271
11EPHB22.51599272
12FGFR12.47651091
13FGFR32.42309304
14PDGFRA2.31634150
15TTN2.30930244
16TYRO32.16401001
17SIK12.12975889
18CDK82.11836689
19CDC72.03069922
20PAK42.03049870
21NEK22.01441600
22CDK121.82240792
23LATS21.81040588
24FGFR41.78831654
25PTK61.78528166
26DYRK21.65143615
27TGFBR11.60745969
28NTRK11.56817065
29MKNK11.54478752
30RPS6KB21.46939664
31RPS6KA41.46517690
32RIPK11.43335191
33PAK21.43087627
34LRRK21.40558481
35MTOR1.28693599
36BMX1.28619476
37PNCK1.28419415
38CDK41.26848958
39STK31.26260121
40TNIK1.19783599
41ILK1.19715754
42PLK41.15592659
43CDK61.13581166
44CDK71.13260107
45EPHA41.12198060
46MELK1.09721224
47PASK1.07429630
48EPHA31.04700254
49CDK91.03146832
50TTK0.99900303
51VRK10.99472943
52WEE10.98928679
53CSNK1G10.96414863
54CAMK1D0.95882634
55SRPK10.95494480
56ERN10.93152406
57STK38L0.93078672
58MKNK20.90369882
59DMPK0.89212306
60FGFR20.89196435
61ERBB20.88604102
62MAP3K70.87467674
63ATR0.85797688
64FLT30.85333117
65PTK20.84350967
66AURKB0.83883470
67CSNK1G30.81604808
68MAP3K80.79400993
69NTRK20.79247630
70BCKDK0.78679172
71ROCK10.77739365
72PLK10.76732502
73FER0.75933673
74ROCK20.74608603
75DYRK30.74500466
76AKT20.73527950
77BRD40.73101237
78PDGFRB0.73080906
79MET0.72867843
80ICK0.71215685
81CSNK1A1L0.71071804
82CDK190.71016896
83TGFBR20.70017456
84CSNK1G20.67791263
85STK100.67776717
86NME20.65062216
87STK160.62755869
88MAPKAPK50.61919682
89SCYL20.61244647
90CHEK10.60504601
91NME10.60101323
92NEK90.59779824
93CDK11A0.59387375
94CDK150.58816123
95DAPK30.56436070
96STK240.55753488
97TSSK60.55477734
98NEK10.55285200
99EPHA20.54990191
100ERBB30.54921739
101RPS6KL10.54564840
102RPS6KC10.54564840
103CAMK1G0.53983499
104TLK10.53204121
105ZAK0.51837724
106CDK180.51298009
107RPS6KA60.47456885
108PRKD30.47236074
109CDK20.46582330
110MAPK150.46239075
111STK40.46148360
112BRSK20.45293977
113CSNK1E0.43785222
114RPS6KA20.43103070
115ALK0.42339751
116DYRK1A0.42067305
117EIF2AK20.41612819
118MAPK90.40670018
119PLK30.40324024
120CHEK20.39306757
121ATM0.38451182
122LMTK20.38444179
123TRPM70.37679045
124PAK10.35801294
125CDK10.35231484
126MAPK10.34177372
127AKT10.32529910
128PTK2B0.31776630
129DYRK1B0.31558239
130MAP2K30.30895257
131BRSK10.30024011
132NUAK10.27607190
133KSR10.26859238
134RPS6KA10.26047036
135IGF1R0.26011106
136AURKA0.25351865
137PRKDC0.25209279

Predicted pathways (KEGG)

RankGene SetZ-score
1* Basal cell carcinoma_Homo sapiens_hsa052173.42205992
2ECM-receptor interaction_Homo sapiens_hsa045122.70862433
3Sulfur relay system_Homo sapiens_hsa041222.57541646
4Notch signaling pathway_Homo sapiens_hsa043302.56098108
5* Hedgehog signaling pathway_Homo sapiens_hsa043402.53789744
6Hippo signaling pathway_Homo sapiens_hsa043902.51216778
7Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.49458113
8DNA replication_Homo sapiens_hsa030302.40627027
9Bladder cancer_Homo sapiens_hsa052192.30745479
10Cell cycle_Homo sapiens_hsa041102.27206129
11MicroRNAs in cancer_Homo sapiens_hsa052062.23167707
12Adherens junction_Homo sapiens_hsa045202.10112758
13Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.07621924
14Focal adhesion_Homo sapiens_hsa045102.04407759
15Small cell lung cancer_Homo sapiens_hsa052222.02484876
16Spliceosome_Homo sapiens_hsa030402.01518058
17* Proteoglycans in cancer_Homo sapiens_hsa052051.99102325
18TGF-beta signaling pathway_Homo sapiens_hsa043501.93332033
19Chronic myeloid leukemia_Homo sapiens_hsa052201.79479264
20Protein digestion and absorption_Homo sapiens_hsa049741.76338158
21RNA transport_Homo sapiens_hsa030131.68274651
22Cysteine and methionine metabolism_Homo sapiens_hsa002701.63041306
23Cyanoamino acid metabolism_Homo sapiens_hsa004601.62549370
24Wnt signaling pathway_Homo sapiens_hsa043101.60917189
25Base excision repair_Homo sapiens_hsa034101.60196600
26Central carbon metabolism in cancer_Homo sapiens_hsa052301.59301557
27HTLV-I infection_Homo sapiens_hsa051661.58812563
28Mismatch repair_Homo sapiens_hsa034301.58043807
29AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.52868914
30mRNA surveillance pathway_Homo sapiens_hsa030151.48622685
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.46941335
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.45288890
33Ribosome_Homo sapiens_hsa030101.44754854
34Colorectal cancer_Homo sapiens_hsa052101.42745707
35* Pathways in cancer_Homo sapiens_hsa052001.38369936
36Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.38362206
37Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.36357084
38p53 signaling pathway_Homo sapiens_hsa041151.36284357
39Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.32275027
40Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.30285102
41Thyroid cancer_Homo sapiens_hsa052161.27113527
42One carbon pool by folate_Homo sapiens_hsa006701.25900117
43Arginine and proline metabolism_Homo sapiens_hsa003301.22583661
44PI3K-Akt signaling pathway_Homo sapiens_hsa041511.22515404
45Melanoma_Homo sapiens_hsa052181.21875228
46Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.21503994
47Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.19154815
48Prostate cancer_Homo sapiens_hsa052151.18278998
49Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.17192920
50Melanogenesis_Homo sapiens_hsa049161.16201408
51Amoebiasis_Homo sapiens_hsa051461.13392717
52Pancreatic cancer_Homo sapiens_hsa052121.12128537
53Lysine degradation_Homo sapiens_hsa003101.11914044
54Viral carcinogenesis_Homo sapiens_hsa052031.10097044
55Arginine biosynthesis_Homo sapiens_hsa002201.08379020
56Dorso-ventral axis formation_Homo sapiens_hsa043201.08334295
57Endometrial cancer_Homo sapiens_hsa052131.07781518
58Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.07548257
59Thyroid hormone signaling pathway_Homo sapiens_hsa049191.06561939
60Viral myocarditis_Homo sapiens_hsa054161.05880254
61Vitamin B6 metabolism_Homo sapiens_hsa007501.05764154
62Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.05393931
63Tight junction_Homo sapiens_hsa045301.05012105
64Transcriptional misregulation in cancer_Homo sapiens_hsa052021.00661008
65Nucleotide excision repair_Homo sapiens_hsa034201.00007621
66Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.97759669
67Carbon metabolism_Homo sapiens_hsa012000.96599474
68Systemic lupus erythematosus_Homo sapiens_hsa053220.94553810
69Axon guidance_Homo sapiens_hsa043600.93828925
70Pentose and glucuronate interconversions_Homo sapiens_hsa000400.92566715
71Steroid biosynthesis_Homo sapiens_hsa001000.92175742
72Pyruvate metabolism_Homo sapiens_hsa006200.89803920
73Rap1 signaling pathway_Homo sapiens_hsa040150.88380412
74Regulation of actin cytoskeleton_Homo sapiens_hsa048100.87402222
75Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.87247882
76Glioma_Homo sapiens_hsa052140.86728617
77Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.83727862
78Leukocyte transendothelial migration_Homo sapiens_hsa046700.83654559
79Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.83131231
80Dilated cardiomyopathy_Homo sapiens_hsa054140.82340654
81Non-small cell lung cancer_Homo sapiens_hsa052230.81620266
82mTOR signaling pathway_Homo sapiens_hsa041500.79559960
83Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.77168049
84Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.76963927
85Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.76776411
86Galactose metabolism_Homo sapiens_hsa000520.76215375
87Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.75249234
88Pyrimidine metabolism_Homo sapiens_hsa002400.73185709
89N-Glycan biosynthesis_Homo sapiens_hsa005100.70467374
90Hepatitis B_Homo sapiens_hsa051610.69881951
91RNA degradation_Homo sapiens_hsa030180.69713634
92RNA polymerase_Homo sapiens_hsa030200.68804744
93Fanconi anemia pathway_Homo sapiens_hsa034600.67203969
94Pentose phosphate pathway_Homo sapiens_hsa000300.65620318
95Tyrosine metabolism_Homo sapiens_hsa003500.65371469
96Complement and coagulation cascades_Homo sapiens_hsa046100.64807614
97Vitamin digestion and absorption_Homo sapiens_hsa049770.63485164
98Bile secretion_Homo sapiens_hsa049760.63375255
99Acute myeloid leukemia_Homo sapiens_hsa052210.62939253
100Fatty acid degradation_Homo sapiens_hsa000710.62203308
101Platelet activation_Homo sapiens_hsa046110.61525494
102Folate biosynthesis_Homo sapiens_hsa007900.61408126
103Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59820612
104Non-homologous end-joining_Homo sapiens_hsa034500.59778160
105Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.59397928
106Oocyte meiosis_Homo sapiens_hsa041140.59255505
107Fat digestion and absorption_Homo sapiens_hsa049750.57986086
108AMPK signaling pathway_Homo sapiens_hsa041520.56406816
109Retinol metabolism_Homo sapiens_hsa008300.56208013
110HIF-1 signaling pathway_Homo sapiens_hsa040660.56157808
111Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.55507672
112Fatty acid metabolism_Homo sapiens_hsa012120.55123175
113Toxoplasmosis_Homo sapiens_hsa051450.54131531
114Neurotrophin signaling pathway_Homo sapiens_hsa047220.53818331
115Phenylalanine metabolism_Homo sapiens_hsa003600.53181940
116Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.53165685
117Apoptosis_Homo sapiens_hsa042100.52965238
118Homologous recombination_Homo sapiens_hsa034400.52928337
119Renal cell carcinoma_Homo sapiens_hsa052110.51227579
120Selenocompound metabolism_Homo sapiens_hsa004500.50727620
121Primary bile acid biosynthesis_Homo sapiens_hsa001200.50491840
122FoxO signaling pathway_Homo sapiens_hsa040680.48136971
123Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45920489
124Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45001644
125Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.44468281
126Herpes simplex infection_Homo sapiens_hsa051680.44083809
127Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.43902126
128Shigellosis_Homo sapiens_hsa051310.43830045
129Gap junction_Homo sapiens_hsa045400.43302804
130Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.42800656
131Insulin resistance_Homo sapiens_hsa049310.41233458
132Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.40759636
133Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.38900372
134Insulin signaling pathway_Homo sapiens_hsa049100.36974809
135Metabolic pathways_Homo sapiens_hsa011000.36417774
136Alcoholism_Homo sapiens_hsa050340.35964069
137Malaria_Homo sapiens_hsa051440.33807424
138Estrogen signaling pathway_Homo sapiens_hsa049150.33418881
139Prion diseases_Homo sapiens_hsa050200.32748995
140Biosynthesis of amino acids_Homo sapiens_hsa012300.31081554
141Renin-angiotensin system_Homo sapiens_hsa046140.30349873
142TNF signaling pathway_Homo sapiens_hsa046680.30103447

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