SMOC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the SPARC family (secreted protein acidic and rich in cysteine/osteonectin/BM-40), which are highly expressed during embryogenesis and wound healing. The gene product is a matricellular protein which promotes matrix assembly and can stimulate endothelial cell proliferation and migration, as well as angiogenic activity. Associated with pulmonary function, this secretory gene product contains a Kazal domain, two thymoglobulin type-1 domains, and two EF-hand calcium-binding domains. The encoded protein may serve as a target for controlling angiogenesis in tumor growth and myocardial ischemia. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratan sulfate catabolic process (GO:0042340)7.59802755
2dermatan sulfate biosynthetic process (GO:0030208)7.12868264
3dermatan sulfate metabolic process (GO:0030205)6.55982496
4protein heterotrimerization (GO:0070208)6.54836017
5actin-myosin filament sliding (GO:0033275)6.24002863
6muscle filament sliding (GO:0030049)6.24002863
7positive regulation of respiratory burst (GO:0060267)5.99517206
8barbed-end actin filament capping (GO:0051016)5.90949341
9cellular response to cadmium ion (GO:0071276)5.83558407
10collagen fibril organization (GO:0030199)5.80646988
11negative regulation of complement activation (GO:0045916)5.73739072
12bone trabecula formation (GO:0060346)5.43811253
13actin-mediated cell contraction (GO:0070252)5.28813850
14chondroitin sulfate catabolic process (GO:0030207)5.08593466
15myofibril assembly (GO:0030239)4.97160994
16positive regulation of glycogen biosynthetic process (GO:0045725)4.95937575
17negative regulation of protein activation cascade (GO:2000258)4.70345282
18cardiac myofibril assembly (GO:0055003)4.67027729
19chondroitin sulfate biosynthetic process (GO:0030206)4.56408355
20sarcoplasmic reticulum calcium ion transport (GO:0070296)4.53100957
21endodermal cell differentiation (GO:0035987)4.38322402
22skeletal muscle contraction (GO:0003009)4.35290488
23opsonization (GO:0008228)4.20642958
24positive regulation of glycogen metabolic process (GO:0070875)4.15751366
25actin filament-based movement (GO:0030048)4.15063453
26extracellular fibril organization (GO:0043206)4.13261146
27sequestering of extracellular ligand from receptor (GO:0035581)4.12474919
28thyroid hormone generation (GO:0006590)4.08973927
29sarcomere organization (GO:0045214)4.08280177
30collagen metabolic process (GO:0032963)4.07453824
31glomerular basement membrane development (GO:0032836)4.02093604
32collagen catabolic process (GO:0030574)4.01920770
33sulfur compound catabolic process (GO:0044273)3.99188255
34blood vessel maturation (GO:0001955)3.90101113
35extracellular matrix disassembly (GO:0022617)3.87453084
36multicellular organismal macromolecule metabolic process (GO:0044259)3.86280730
37striated muscle contraction (GO:0006941)3.84434791
38atrioventricular valve morphogenesis (GO:0003181)3.83468003
39myelination in peripheral nervous system (GO:0022011)3.81839025
40peripheral nervous system axon ensheathment (GO:0032292)3.81839025
41multicellular organismal catabolic process (GO:0044243)3.73989851
42retina vasculature morphogenesis in camera-type eye (GO:0061299)3.70234575
43positive regulation of macrophage cytokine production (GO:0060907)3.70027921
44regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.68460754
45multicellular organismal metabolic process (GO:0044236)3.66909310
46peptide cross-linking (GO:0018149)3.66307681
47fibril organization (GO:0097435)3.65508558
48actomyosin structure organization (GO:0031032)3.63202342
49hemidesmosome assembly (GO:0031581)3.61145758
50protein retention in ER lumen (GO:0006621)3.61067025
51regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.60998879
52regulation of macrophage cytokine production (GO:0010935)3.60422072
53regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.60359565
54glycosaminoglycan catabolic process (GO:0006027)3.60013662
55cardiac muscle contraction (GO:0060048)3.56673615
56maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.55509157
57exocrine pancreas development (GO:0031017)3.54830063
58extracellular matrix assembly (GO:0085029)3.52996144
59positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.51605375
60peptidyl-proline hydroxylation (GO:0019511)3.50165381
61regulation of relaxation of muscle (GO:1901077)3.46691096
62regulation of plasminogen activation (GO:0010755)3.46440527
63negative regulation of humoral immune response (GO:0002921)3.45485237
64basement membrane organization (GO:0071711)3.43435126
65* extracellular matrix organization (GO:0030198)3.39551317
66aminoglycan catabolic process (GO:0006026)3.39266442
67* extracellular structure organization (GO:0043062)3.38291729
68NADH metabolic process (GO:0006734)3.35017412
69creatine metabolic process (GO:0006600)3.32850117
70thyroid hormone metabolic process (GO:0042403)3.31813794
71muscle contraction (GO:0006936)3.31049954
72glomerular filtration (GO:0003094)3.30777647
73trabecula formation (GO:0060343)3.27299665
74glycosaminoglycan biosynthetic process (GO:0006024)3.25505058
75nucleoside diphosphate catabolic process (GO:0009134)3.24717497
76metanephric mesenchyme development (GO:0072075)3.23365945
77face morphogenesis (GO:0060325)3.21572533
78aminoglycan biosynthetic process (GO:0006023)3.20987510
79glomerulus development (GO:0032835)3.20258866
80cellular response to epinephrine stimulus (GO:0071872)3.15388876
81endothelial cell proliferation (GO:0001935)3.12960036
82cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.12432056
83cell migration involved in heart development (GO:0060973)3.12314463
84response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.10209854
85chondrocyte proliferation (GO:0035988)3.09954244
86cardiac muscle hypertrophy (GO:0003300)3.07203576
87regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.06290575
88homocysteine metabolic process (GO:0050667)3.02864545
89regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.01808875
90muscle system process (GO:0003012)3.00058091
91response to follicle-stimulating hormone (GO:0032354)2.98191936
92peptidyl-tyrosine autophosphorylation (GO:0038083)2.98025232
93cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.97933679
94keratan sulfate metabolic process (GO:0042339)2.97385707
95muscle hypertrophy (GO:0014896)2.97201691
96regulation of integrin-mediated signaling pathway (GO:2001044)2.97035432
97striated muscle hypertrophy (GO:0014897)2.96896936
98positive regulation of fatty acid oxidation (GO:0046321)2.93840042
99regulation of actin filament-based movement (GO:1903115)2.92331886
100endothelial cell morphogenesis (GO:0001886)2.92246350
101regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.91842764
102vascular endothelial growth factor signaling pathway (GO:0038084)2.90441827
103renal filtration (GO:0097205)2.90325957
104positive regulation of cartilage development (GO:0061036)2.89632539
105response to inactivity (GO:0014854)2.88840950
106response to epinephrine (GO:0071871)2.88622907
107response to folic acid (GO:0051593)2.88526084
108keratan sulfate biosynthetic process (GO:0018146)2.86765331
109endothelial cell chemotaxis (GO:0035767)2.85845643
110cell adhesion mediated by integrin (GO:0033627)2.85819702
111kidney mesenchyme development (GO:0072074)2.85763830
112positive regulation of extracellular matrix organization (GO:1903055)2.85162872
113negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.84343990
114negative regulation of cardiac muscle tissue growth (GO:0055022)2.84239738
115negative regulation of heart growth (GO:0061117)2.84239738
116negative regulation of catenin import into nucleus (GO:0035414)2.83228904
117regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.83061127
118myotube cell development (GO:0014904)2.82774817
119endocardial cushion morphogenesis (GO:0003203)2.81619117
120cGMP-mediated signaling (GO:0019934)2.81252070
121positive regulation of glucose import (GO:0046326)2.79516013
122thyroid gland development (GO:0030878)2.79411577
123chondroitin sulfate metabolic process (GO:0030204)2.79225287
124wound healing, spreading of epidermal cells (GO:0035313)2.78725842
125desmosome organization (GO:0002934)2.77483040
126wound healing (GO:0042060)2.77108232
127protein hydroxylation (GO:0018126)2.75918595
128cell proliferation involved in kidney development (GO:0072111)2.74963590
129muscle tissue morphogenesis (GO:0060415)2.73849480
130negative regulation of chondrocyte differentiation (GO:0032331)2.73626494
131cardiac muscle tissue morphogenesis (GO:0055008)2.72930797
132regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.72396279
133skin morphogenesis (GO:0043589)2.72185767
134regulation of complement activation (GO:0030449)2.71267632
135cardiac muscle cell development (GO:0055013)2.68977905
136metanephric nephron tubule development (GO:0072234)2.67923703
137metanephric tubule development (GO:0072170)2.67923703
138metanephric nephron epithelium development (GO:0072243)2.67329878
139regulation of the force of heart contraction (GO:0002026)2.66923193
140cellular response to nitric oxide (GO:0071732)2.65813084
141regulation of sequestering of triglyceride (GO:0010889)2.65756923
142skeletal muscle adaptation (GO:0043501)2.65457545
143mesenchyme morphogenesis (GO:0072132)2.64976212
144regulation of p38MAPK cascade (GO:1900744)2.64652806
145negative regulation of actin filament depolymerization (GO:0030835)2.63957650
146skeletal muscle fiber development (GO:0048741)2.63863557
147cardiac cell development (GO:0055006)2.62494212
148fibrinolysis (GO:0042730)2.62438917
149response to nitric oxide (GO:0071731)2.62173112
150skeletal muscle tissue development (GO:0007519)2.61987153
151striated muscle adaptation (GO:0014888)2.59392111
152regulation of skeletal muscle contraction (GO:0014819)2.57207700
153notochord development (GO:0030903)2.56863251
154regulation of cell communication by electrical coupling (GO:0010649)2.56148777
155epithelial cell-cell adhesion (GO:0090136)2.54197748
156cardiac muscle adaptation (GO:0014887)2.54074995
157cardiac muscle hypertrophy in response to stress (GO:0014898)2.54074995
158muscle hypertrophy in response to stress (GO:0003299)2.54074995
159chondrocyte development (GO:0002063)2.53953070
160metanephric epithelium development (GO:0072207)2.53630123
161smooth muscle tissue development (GO:0048745)2.53623274
162negative regulation of potassium ion transmembrane transport (GO:1901380)2.51886495
163adhesion of symbiont to host (GO:0044406)2.51019432
164negative regulation of protein localization to cell surface (GO:2000009)2.50187905
165carnitine shuttle (GO:0006853)2.47300305
166response to muscle activity (GO:0014850)2.45985667
167myoblast fusion (GO:0007520)2.44349702
168muscle organ development (GO:0007517)2.44326063
169insulin-like growth factor receptor signaling pathway (GO:0048009)2.42483288
170fibroblast migration (GO:0010761)2.41247420
171muscle fiber development (GO:0048747)2.41243576
172muscle structure development (GO:0061061)2.40983913
173endocrine hormone secretion (GO:0060986)2.37449332
174positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.36630399
175muscle tissue development (GO:0060537)2.34341839
176regulation of striated muscle contraction (GO:0006942)2.34308746
177ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.33132938
178regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.31453004
179regulation of cardioblast differentiation (GO:0051890)2.30115312
180adhesion of symbiont to host cell (GO:0044650)2.29955807
181virion attachment to host cell (GO:0019062)2.29955807
182peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)10.4330527

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human6.11177779
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.64032212
3GATA1_22025678_ChIP-Seq_K562_Human5.48433358
4RARG_19884340_ChIP-ChIP_MEFs_Mouse4.27844707
5PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.71478442
6CLOCK_20551151_ChIP-Seq_293T_Human2.93726014
7TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.86857960
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.79305972
9ESR1_21235772_ChIP-Seq_MCF-7_Human2.75809961
10EZH2_22144423_ChIP-Seq_EOC_Human2.68820837
11CJUN_26792858_Chip-Seq_BT549_Human2.52309566
12* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.49951358
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.32390028
14CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.23438242
15CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.22611272
16THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.22175951
17ESR2_21235772_ChIP-Seq_MCF-7_Human2.12673564
18* AR_21572438_ChIP-Seq_LNCaP_Human2.09629855
19RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.08132243
20EED_16625203_ChIP-ChIP_MESCs_Mouse1.98267952
21* EP300_21415370_ChIP-Seq_HL-1_Mouse1.92827671
22TP53_16413492_ChIP-PET_HCT116_Human1.85421514
23HIF1A_21447827_ChIP-Seq_MCF-7_Human1.69021822
24SMAD_19615063_ChIP-ChIP_OVARY_Human1.65455831
25* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.63631792
26NRF2_20460467_ChIP-Seq_MEFs_Mouse1.59694750
27NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.59694750
28CDX2_19796622_ChIP-Seq_MESCs_Mouse1.59535910
29* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.58892245
30* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.58892245
31TP53_20018659_ChIP-ChIP_R1E_Mouse1.56527306
32PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.54509025
33* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.53921200
34ZNF217_24962896_ChIP-Seq_MCF-7_Human1.52265882
35BRD4_25478319_ChIP-Seq_HGPS_Human1.51405440
36MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.50129905
37JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.47170565
38* SOX2_20726797_ChIP-Seq_SW620_Human1.46672526
39PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.46442093
40PPAR_26484153_Chip-Seq_NCI-H1993_Human1.44931599
41BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.44771358
42STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.44112028
43FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.43229087
44JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.42854276
45NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.42194498
46ESR1_20079471_ChIP-ChIP_T-47D_Human1.42160301
47* DROSHA_22980978_ChIP-Seq_HELA_Human1.38432095
48* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.37146774
49SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.36756339
50TP53_18474530_ChIP-ChIP_U2OS_Human1.35682989
51WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.35436385
52* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.35417692
53ELK3_25401928_ChIP-Seq_HUVEC_Human1.34311738
54P63_26484246_Chip-Seq_KERATINOCYTES_Human1.33305265
55HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.30031520
56* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.29485697
57SOX9_24532713_ChIP-Seq_HFSC_Mouse1.29336747
58CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.28556997
59NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.28347710
60SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.27682447
61EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.27377062
62HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.26097540
63TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25698667
64SALL4_18804426_ChIP-ChIP_XEN_Mouse1.25238912
65UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.24702443
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.21155277
67RACK7_27058665_Chip-Seq_MCF-7_Human1.20869950
68RBPJ_22232070_ChIP-Seq_NCS_Mouse1.20057532
69TBX20_22328084_ChIP-Seq_HEART_Mouse1.19388494
70TBX20_22080862_ChIP-Seq_HEART_Mouse1.19388494
71RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19212902
72* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.17379097
73SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.17256296
74SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.17256296
75* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.16858152
76BCAT_22108803_ChIP-Seq_LS180_Human1.16185139
77* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.14888705
78MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.14382788
79RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.14129883
80ISL1_27105846_Chip-Seq_CPCs_Mouse1.12570455
81SMC1_22415368_ChIP-Seq_MEFs_Mouse1.11729836
82GBX2_23144817_ChIP-Seq_PC3_Human1.08913010
83ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.08001193
84SMAD3_21741376_ChIP-Seq_HESCs_Human1.05084124
85UBF1/2_26484160_Chip-Seq_HMECs_Human1.04425612
86GATA2_21666600_ChIP-Seq_HMVEC_Human1.01891087
87PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.01534866
88PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.00879723
89ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.99030339
90RXR_22158963_ChIP-Seq_LIVER_Mouse0.98878706
91TCF4_18268006_ChIP-ChIP_LS174T_Human0.97873194
92RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.97665539
93TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.97378113
94NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.97209300
95* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.97060652
96WT1_19549856_ChIP-ChIP_CCG9911_Human0.96492985
97NR3C1_23031785_ChIP-Seq_PC12_Mouse0.95948713
98TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95074138
99PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.94199827
100CTNNB1_20460455_ChIP-Seq_HCT116_Human0.94152567
101EZH2_27304074_Chip-Seq_ESCs_Mouse0.93724511
102* RING1B_27294783_Chip-Seq_NPCs_Mouse0.92770855
103CTCF_27219007_Chip-Seq_Bcells_Human0.92101510
104* KLF5_25053715_ChIP-Seq_YYC3_Human0.91834402
105* RNF2_27304074_Chip-Seq_ESCs_Mouse0.90692889
106ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.90252235
107LXR_22158963_ChIP-Seq_LIVER_Mouse0.89830795
108FOXO3_23340844_ChIP-Seq_DLD1_Human0.89744795
109RING1B_27294783_Chip-Seq_ESCs_Mouse0.89721336
110HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.89427875
111TP53_22127205_ChIP-Seq_IMR90_Human0.89018834
112SA1_22415368_ChIP-Seq_MEFs_Mouse0.88765783
113YAP1_20516196_ChIP-Seq_MESCs_Mouse0.88639629
114* TP53_23651856_ChIP-Seq_MEFs_Mouse0.88602717
115NFIB_24661679_ChIP-Seq_LUNG_Mouse0.88129919
116KDM2B_26808549_Chip-Seq_K562_Human0.87595834
117TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.87139193
118SMAD4_21741376_ChIP-Seq_HESCs_Human0.86608171
119AHR_22903824_ChIP-Seq_MCF-7_Human0.86189330
120ERG_21242973_ChIP-ChIP_JURKAT_Human0.84671311
121SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.84025190
122SMC3_22415368_ChIP-Seq_MEFs_Mouse0.83757829
123CBX2_27304074_Chip-Seq_ESCs_Mouse0.83698236
124EZH2_27294783_Chip-Seq_ESCs_Mouse0.83194595
125KDM2B_26808549_Chip-Seq_SUP-B15_Human0.82693485
126JARID2_20064375_ChIP-Seq_MESCs_Mouse0.81948044
127KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.80829011
128TP63_23658742_ChIP-Seq_EP156T_Human0.79122467
129ZFP281_18757296_ChIP-ChIP_E14_Mouse0.78705975
130ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.78368734
131P300_27058665_Chip-Seq_ZR-75-30cells_Human0.78266562
132EGR1_19374776_ChIP-ChIP_THP-1_Human0.77524931
133SUZ12_27294783_Chip-Seq_ESCs_Mouse0.76975319
134* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.76826011

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen9.07145268
2MP0005503_abnormal_tendon_morphology8.50625526
3MP0005275_abnormal_skin_tensile6.91703365
4MP0004145_abnormal_muscle_electrophysio3.34261349
5MP0004272_abnormal_basement_membrane3.23033020
6MP0001958_emphysema2.89057640
7MP0000751_myopathy2.80343683
8MP0003705_abnormal_hypodermis_morpholog2.75792638
9MP0002108_abnormal_muscle_morphology2.73495920
10MP0005508_abnormal_skeleton_morphology2.69251574
11MP0005670_abnormal_white_adipose2.50634843
12MP0006054_spinal_hemorrhage2.43020080
13MP0002060_abnormal_skin_morphology2.39836674
14MP0003279_aneurysm2.37648685
15MP0004130_abnormal_muscle_cell2.06912001
16MP0002106_abnormal_muscle_physiology2.00258158
17MP0006138_congestive_heart_failure1.94186070
18MP0004215_abnormal_myocardial_fiber1.78349988
19MP0005023_abnormal_wound_healing1.76358094
20MP0002876_abnormal_thyroid_physiology1.72791736
21MP0003566_abnormal_cell_adhesion1.70620079
22MP0002295_abnormal_pulmonary_circulatio1.68729872
23MP0001243_abnormal_dermal_layer1.65533055
24MP0003941_abnormal_skin_development1.61022425
25MP0005666_abnormal_adipose_tissue1.60374500
26MP0002089_abnormal_postnatal_growth/wei1.58618698
27MP0000749_muscle_degeneration1.58072851
28MP0009384_cardiac_valve_regurgitation1.48975642
29MP0005390_skeleton_phenotype1.47919563
30MP0002269_muscular_atrophy1.45532649
31MP0002933_joint_inflammation1.44209036
32MP0010368_abnormal_lymphatic_system1.43235764
33MP0010630_abnormal_cardiac_muscle1.42144681
34MP0000163_abnormal_cartilage_morphology1.41692811
35MP0005375_adipose_tissue_phenotype1.40244054
36MP0003283_abnormal_digestive_organ1.35192574
37MP0005623_abnormal_meninges_morphology1.29694214
38MP0009250_abnormal_appendicular_skeleto1.29063681
39MP0005257_abnormal_intraocular_pressure1.28710615
40MP0000681_abnormal_thyroid_gland1.27147756
41MP0002971_abnormal_brown_adipose1.26992809
42MP0001661_extended_life_span1.26724045
43MP0005084_abnormal_gallbladder_morpholo1.25865890
44MP0000750_abnormal_muscle_regeneration1.21675747
45MP0002127_abnormal_cardiovascular_syste1.20290661
46MP0003011_delayed_dark_adaptation1.19683066
47MP0003950_abnormal_plasma_membrane1.18522491
48MP0002282_abnormal_trachea_morphology1.16984632
49MP0002115_abnormal_skeleton_extremities1.16679248
50MP0004858_abnormal_nervous_system1.10305058
51MP0003115_abnormal_respiratory_system1.07507960
52MP0004233_abnormal_muscle_weight1.05776951
53MP0003385_abnormal_body_wall1.04225569
54MP0000013_abnormal_adipose_tissue1.03443638
55MP0002896_abnormal_bone_mineralization1.03409955
56MP0005369_muscle_phenotype1.03258258
57MP0000462_abnormal_digestive_system1.00705292
58MP0002249_abnormal_larynx_morphology1.00598428
59MP0004134_abnormal_chest_morphology0.98986286
60MP0000678_abnormal_parathyroid_gland0.96902040
61MP0003828_pulmonary_edema0.93059698
62MP0003137_abnormal_impulse_conducting0.92023134
63MP0000534_abnormal_ureter_morphology0.91763191
64MP0001533_abnormal_skeleton_physiology0.91731200
65MP0004185_abnormal_adipocyte_glucose0.91466847
66MP0004084_abnormal_cardiac_muscle0.91282196
67MP0002332_abnormal_exercise_endurance0.90999105
68MP0002113_abnormal_skeleton_development0.88336591
69MP0009780_abnormal_chondrocyte_physiolo0.87006057
70MP0000767_abnormal_smooth_muscle0.85657839
71MP0004085_abnormal_heartbeat0.85097770
72MP0003646_muscle_fatigue0.84973819
73MP0000613_abnormal_salivary_gland0.83959269
74MP0001542_abnormal_bone_strength0.83608920
75MP0000733_abnormal_muscle_development0.83159713
76MP0005409_darkened_coat_color0.82125059
77MP0000762_abnormal_tongue_morphology0.81888940
78MP0002998_abnormal_bone_remodeling0.81731716
79MP0005165_increased_susceptibility_to0.81328687
80MP0005595_abnormal_vascular_smooth0.80810237
81MP0000049_abnormal_middle_ear0.80359415
82MP0010771_integument_phenotype0.79883858
83MP0004484_altered_response_of0.79629589
84MP0000759_abnormal_skeletal_muscle0.79204810
85MP0003879_abnormal_hair_cell0.79087456
86MP0002837_dystrophic_cardiac_calcinosis0.78845785
87MP0000747_muscle_weakness0.76812312
88MP0005330_cardiomyopathy0.75819360
89MP0004036_abnormal_muscle_relaxation0.74513319
90MP0001879_abnormal_lymphatic_vessel0.73928692
91MP0010030_abnormal_orbit_morphology0.73486994
92MP0000003_abnormal_adipose_tissue0.71591609
93MP0000383_abnormal_hair_follicle0.71254492
94MP0005620_abnormal_muscle_contractility0.69888760
95MP0010352_gastrointestinal_tract_polyps0.69653117
96MP0004087_abnormal_muscle_fiber0.69636212
97MP0003091_abnormal_cell_migration0.69212139
98MP0003075_altered_response_to0.68723709
99MP0000266_abnormal_heart_morphology0.67915340
100MP0003795_abnormal_bone_structure0.67743558
101MP0002109_abnormal_limb_morphology0.67662661
102MP0000230_abnormal_systemic_arterial0.66638780
103MP0008775_abnormal_heart_ventricle0.64988380
104MP0000428_abnormal_craniofacial_morphol0.64603982
105MP0008004_abnormal_stomach_pH0.64552297
106MP0001175_abnormal_lung_morphology0.63928535
107MP0005451_abnormal_body_composition0.63680125
108MP0003045_fibrosis0.63662008
109MP0002233_abnormal_nose_morphology0.63658960
110MP0002932_abnormal_joint_morphology0.63631503
111MP0009115_abnormal_fat_cell0.62737272
112MP0002116_abnormal_craniofacial_bone0.60936707
113MP0003755_abnormal_palate_morphology0.60609671
114MP0003942_abnormal_urinary_system0.59526543
115MP0004885_abnormal_endolymph0.58978217
116MP0001614_abnormal_blood_vessel0.58633365
117MP0001501_abnormal_sleep_pattern0.58196965
118MP0003252_abnormal_bile_duct0.57464932
119MP0001299_abnormal_eye_distance/0.55798536
120MP0004510_myositis0.55372660
121MP0000537_abnormal_urethra_morphology0.55304375
122MP0002796_impaired_skin_barrier0.53798364
123MP0002972_abnormal_cardiac_muscle0.53508639
124MP0005385_cardiovascular_system_phenoty0.53318622
125MP0001544_abnormal_cardiovascular_syste0.53318622
126MP0009379_abnormal_foot_pigmentation0.52544504
127MP0000432_abnormal_head_morphology0.52516983
128MP0000343_altered_response_to0.52306745
129MP0004043_abnormal_pH_regulation0.52268631
130MP0005388_respiratory_system_phenotype0.51970494
131MP0002133_abnormal_respiratory_system0.51970494
132MP0001756_abnormal_urination0.51437626
133MP0010678_abnormal_skin_adnexa0.50784392
134MP0005167_abnormal_blood-brain_barrier0.50557277
135MP0000249_abnormal_blood_vessel0.50460675
136MP0002128_abnormal_blood_circulation0.49544245
137MP0003935_abnormal_craniofacial_develop0.49478875

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)7.96437485
2Nemaline bodies (HP:0003798)6.27906266
3Muscle fiber inclusion bodies (HP:0100299)6.23660724
4Cervical subluxation (HP:0003308)6.23366809
5Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)6.12573964
6Premature rupture of membranes (HP:0001788)5.99655315
7Wrist flexion contracture (HP:0001239)5.99366365
8Broad metatarsal (HP:0001783)5.75264127
9Ankle contracture (HP:0006466)5.74653619
10Neonatal short-limb short stature (HP:0008921)5.45497242
11Exercise-induced myalgia (HP:0003738)5.18065870
12Distal arthrogryposis (HP:0005684)4.56949948
13Round ear (HP:0100830)4.19998267
14Hyporeflexia of lower limbs (HP:0002600)4.09682121
15Aortic dissection (HP:0002647)4.06251580
16Exercise-induced muscle cramps (HP:0003710)3.86097720
17Type 1 muscle fiber predominance (HP:0003803)3.83175805
18Vertebral compression fractures (HP:0002953)3.82203235
19Calcaneovalgus deformity (HP:0001848)3.81101882
20Aortic aneurysm (HP:0004942)3.63652096
21Muscle hypertrophy of the lower extremities (HP:0008968)3.60624338
22Ileus (HP:0002595)3.58062682
23Soft skin (HP:0000977)3.54708644
24Spinal rigidity (HP:0003306)3.52676273
25Neck muscle weakness (HP:0000467)3.40406179
26Calf muscle hypertrophy (HP:0008981)3.40179322
27Shallow orbits (HP:0000586)3.39411727
28EMG: myopathic abnormalities (HP:0003458)3.36721437
29Follicular hyperkeratosis (HP:0007502)3.35686772
30Myopathic facies (HP:0002058)3.34588044
31Deformed tarsal bones (HP:0008119)3.33595205
32Mitral stenosis (HP:0001718)3.33090536
33Sudden death (HP:0001699)3.27235278
34Atrophic scars (HP:0001075)3.24976839
35Centrally nucleated skeletal muscle fibers (HP:0003687)3.22297732
36Asymmetric septal hypertrophy (HP:0001670)3.18925835
37Increased connective tissue (HP:0009025)3.18296008
38Right ventricular cardiomyopathy (HP:0011663)3.12481365
39Bladder diverticulum (HP:0000015)3.07853044
40Hip contracture (HP:0003273)3.01841994
41Difficulty running (HP:0009046)3.00149891
42Mild short stature (HP:0003502)2.98280473
43J-shaped sella turcica (HP:0002680)2.92193129
44Joint stiffness (HP:0001387)2.88936097
45Subaortic stenosis (HP:0001682)2.87912684
46Abnormality of the left ventricular outflow tract (HP:0011103)2.87912684
47Ventricular tachycardia (HP:0004756)2.85350527
48Dilatation of the ascending aorta (HP:0005111)2.83153154
49Enlarged penis (HP:0000040)2.82754769
50Amyloidosis (HP:0011034)2.76834664
51Cerebral aneurysm (HP:0004944)2.73391537
52Abnormality of the acetabulum (HP:0003170)2.72307276
53Rhabdomyolysis (HP:0003201)2.70651555
54Myoglobinuria (HP:0002913)2.70507492
55Vascular tortuosity (HP:0004948)2.69852852
56Bundle branch block (HP:0011710)2.68572622
57Advanced eruption of teeth (HP:0006288)2.68120753
58Absent phalangeal crease (HP:0006109)2.64296829
59Myotonia (HP:0002486)2.64159387
60Lipoatrophy (HP:0100578)2.62352186
61Blue sclerae (HP:0000592)2.59948508
62Beaking of vertebral bodies (HP:0004568)2.59175973
63Fragile skin (HP:0001030)2.58892387
64Limited hip movement (HP:0008800)2.57562031
65Abnormality of the ischium (HP:0003174)2.54813500
66Ulnar deviation of the wrist (HP:0003049)2.51198932
67Goiter (HP:0000853)2.48232620
68Wormian bones (HP:0002645)2.46973907
69Breech presentation (HP:0001623)2.46840635
70Slender build (HP:0001533)2.46521255
71Abnormality of the calcaneus (HP:0008364)2.43744871
72Rimmed vacuoles (HP:0003805)2.42542675
73Increased variability in muscle fiber diameter (HP:0003557)2.40969142
74Arterial tortuosity (HP:0005116)2.39119418
75Muscle fiber splitting (HP:0003555)2.38145650
76Natal tooth (HP:0000695)2.37863752
77Mildly elevated creatine phosphokinase (HP:0008180)2.37696790
78Mitral valve prolapse (HP:0001634)2.35338700
79Biconcave vertebral bodies (HP:0004586)2.35221412
80Corneal dystrophy (HP:0001131)2.31732844
81Absent epiphyses (HP:0010577)2.31160932
82Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.31160932
83Dilated cardiomyopathy (HP:0001644)2.27411133
84Epiphyseal dysplasia (HP:0002656)2.21586113
85Thick nail (HP:0001805)2.19543807
86Tarsal synostosis (HP:0008368)2.18076258
87Bulbar palsy (HP:0001283)2.17111615
88Coxa vara (HP:0002812)2.16921604
89Aortic valve stenosis (HP:0001650)2.16138612
90Scapular winging (HP:0003691)2.15333000
91EMG: neuropathic changes (HP:0003445)2.15024268
92Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)2.12928794
93Thin bony cortex (HP:0002753)2.12557874
94Abnormality of dentin (HP:0010299)2.12440962
95Abnormal finger flexion creases (HP:0006143)2.11667692
96Reduced subcutaneous adipose tissue (HP:0003758)2.10905810
97Abnormality of skeletal muscle fiber size (HP:0012084)2.10779044
98Complement deficiency (HP:0004431)2.10543650
99Peritonitis (HP:0002586)2.08280104
100Joint laxity (HP:0001388)2.08096633
101Cupped ribs (HP:0000887)2.07973418
102Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.07268266
103Bell-shaped thorax (HP:0001591)2.06460229
104Hypoplasia of the capital femoral epiphysis (HP:0003090)2.06374601
105Congenital, generalized hypertrichosis (HP:0004540)2.06182382
106Overgrowth (HP:0001548)2.05486097
107Platyspondyly (HP:0000926)2.05469609
108Malignant hyperthermia (HP:0002047)2.05321182
109Areflexia of lower limbs (HP:0002522)2.04744153
110Hypoplasia of the iris (HP:0007676)2.04321173
111Atrial fibrillation (HP:0005110)2.02720468
112Hyperextensible skin (HP:0000974)2.01970183
113Distal lower limb amyotrophy (HP:0008944)2.01556608
114Abnormality of the foot musculature (HP:0001436)1.99882790
115Systemic lupus erythematosus (HP:0002725)1.99242864
116Muscle stiffness (HP:0003552)1.98800361
117Frequent falls (HP:0002359)1.98656605
118Hypoplastic ischia (HP:0003175)1.97425237
119Generalized amyotrophy (HP:0003700)1.97311691
120Osteoarthritis (HP:0002758)1.92946970
121Synostosis involving bones of the feet (HP:0009140)1.92927954
122Synostosis involving bones of the lower limbs (HP:0009138)1.92927954
123Thyroid-stimulating hormone excess (HP:0002925)1.92638164
124Infantile muscular hypotonia (HP:0008947)1.92436063
125Ovoid vertebral bodies (HP:0003300)1.92171326
126Acanthosis nigricans (HP:0000956)1.91220597
127Bronchomalacia (HP:0002780)1.91108285
128Foot dorsiflexor weakness (HP:0009027)1.90746951
129Osteolytic defects of the phalanges of the hand (HP:0009771)1.90423265
130Osteolytic defects of the hand bones (HP:0009699)1.90423265
131Genu recurvatum (HP:0002816)1.89882947
132Elbow flexion contracture (HP:0002987)1.89235216
133Abnormal atrioventricular conduction (HP:0005150)1.89031697
134Lymphangioma (HP:0100764)1.88231273
135Pulmonary artery stenosis (HP:0004415)1.87683743
136Abnormal delivery (HP:0001787)1.86817528
137Abnormal tarsal ossification (HP:0008369)1.86491474
138Small epiphyses (HP:0010585)1.86264315
139Heart block (HP:0012722)1.85703477
140Abnormality of complement system (HP:0005339)1.85483839
141Distal lower limb muscle weakness (HP:0009053)1.85375248
142Wide anterior fontanel (HP:0000260)1.84573399
143Ectopia lentis (HP:0001083)1.83975780
144Ventricular arrhythmia (HP:0004308)1.82846359
145Camptodactyly of toe (HP:0001836)1.81638659
146Diaphragmatic weakness (HP:0009113)1.81287884
147Gowers sign (HP:0003391)1.81049134
148Mesomelia (HP:0003027)1.80852636
149Syncope (HP:0001279)1.80259469
150Coxa valga (HP:0002673)1.80107838
151Disproportionate short-trunk short stature (HP:0003521)1.79905294
152Primary atrial arrhythmia (HP:0001692)1.79630303
153Pancreatic islet-cell hyperplasia (HP:0004510)1.78961088
154Abnormality of the calf musculature (HP:0001430)1.78675217
155Delayed closure of the anterior fontanelle (HP:0001476)1.76710756
156Osteopenia (HP:0000938)1.76112966
157Hyperkalemia (HP:0002153)1.75281592
158Oligomenorrhea (HP:0000876)1.75035005
159Disproportionate tall stature (HP:0001519)1.74557468
160Muscular dystrophy (HP:0003560)1.74371536
161Aneurysm (HP:0002617)1.74207830
162Deformed sella turcica (HP:0002681)1.72116065
163Vitreoretinal degeneration (HP:0000655)1.72044524
164Conical tooth (HP:0000698)1.70212882

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR8.26335459
2TRPM73.88341591
3PDGFRA3.54576907
4DDR23.21891334
5TTN2.99911266
6STK38L2.36793833
7TGFBR22.31396386
8LATS22.23208944
9ERBB32.20968528
10TRIB32.17974621
11FER2.08416455
12LATS12.07621084
13EPHB22.04515971
14ERN11.92964334
15EPHA31.81309758
16EEF2K1.73352911
17MET1.73188192
18LMTK21.71254951
19PINK11.64139704
20TIE11.57443975
21MAP3K31.56931440
22MAPK121.55915936
23MYLK1.55713403
24FLT31.49227776
25MAP2K71.44979493
26CSK1.42461011
27MAP3K51.36445688
28NTRK11.29217242
29MAP2K21.28149366
30MAP3K61.24972613
31MUSK1.23092492
32AKT31.18880025
33SIK11.13878616
34MAPK71.08979716
35NME11.08125703
36PRKAA21.05925075
37PAK21.05344211
38EPHB11.01149964
39TESK11.00450771
40PTK61.00095940
41MST1R0.96464021
42STK240.95937616
43NLK0.95925985
44PIK3CA0.95597789
45PRKD30.95524551
46TNIK0.94910817
47RIPK10.94145900
48MARK10.93897437
49MOS0.92214894
50ROCK10.91219807
51PRKD20.91046267
52PDGFRB0.85329654
53MAPK40.83906927
54PIK3CG0.82818484
55DAPK20.82303134
56PTK20.81514930
57MTOR0.81318115
58PKN20.80777001
59TNK20.79698426
60TGFBR10.79525039
61ZAK0.78806109
62CAMK2G0.78526241
63FRK0.77636984
64STK30.76303975
65SGK20.74929499
66MAP2K10.74801102
67MAPK150.73498416
68PDK20.71848545
69BCKDK0.70529220
70PRKAA10.69990144
71SGK4940.69925314
72SGK2230.69925314
73MARK20.69908935
74RPS6KA20.68935181
75RPS6KL10.68689969
76RPS6KC10.68689969
77DMPK0.68598380
78CAMK10.67440461
79FGFR40.66064157
80PHKG10.65837956
81PHKG20.65837956
82BMPR20.64284225
83KIT0.63101721
84ICK0.62962104
85PAK30.62915325
86RET0.59238218
87SGK30.58895398
88CAMK2D0.58894089
89ILK0.57845535
90OBSCN0.56765195
91RPS6KA60.55114433
92ROCK20.54544465
93JAK30.54337788
94NEK60.54146774
95CAMK40.54071592
96PTK2B0.52966381
97CAMK1D0.52216652
98EPHA20.50532814
99PLK20.50348376
100PRKG10.50064570
101PRKCH0.49870348
102SCYL20.49204369
103PRKD10.49001786
104MAP3K40.48370795
105JAK10.48084234
106FGFR30.45041302
107PDK30.43597230
108PDK40.43597230
109CAMK2B0.43521534
110PIM20.43198828
111PRKG20.42840680
112TAOK20.42731025
113FGFR10.42729604
114AKT20.42379801
115NME20.41973217
116STK380.41877975
117WNK10.41575357
118MAP2K30.41528700
119MAP3K10.40342469
120PDPK10.39804963
121CAMK2A0.39269323
122CDC42BPA0.39178994
123LIMK10.38185234
124ABL20.34860300
125PRKCE0.34806658
126MAPK100.34540504
127DYRK1B0.33422842
128PRKACG0.33167983
129MAP3K70.31548710
130RPS6KA30.31349107
131BMX0.31033437
132ERBB20.30890884
133CAMK1G0.30603332
134MAPK30.30354390
135NEK90.29875478
136MAPKAPK30.28214556
137RPS6KA40.27699902
138DAPK30.27431556
139PRPF4B0.25385824
140GSK3A0.25368119
141SRC0.24485110
142DYRK20.24080801

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.72316298
2Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005343.55518630
3Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.54408085
4Focal adhesion_Homo sapiens_hsa045102.98813523
5Protein digestion and absorption_Homo sapiens_hsa049742.93644951
6Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.33089201
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.22715990
8Dilated cardiomyopathy_Homo sapiens_hsa054142.18876475
9TGF-beta signaling pathway_Homo sapiens_hsa043502.13155413
10AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.07175103
11Proteoglycans in cancer_Homo sapiens_hsa052051.98097545
12Amoebiasis_Homo sapiens_hsa051461.95432310
13Thyroid hormone synthesis_Homo sapiens_hsa049181.91932696
14Bladder cancer_Homo sapiens_hsa052191.79142324
15Glycosaminoglycan degradation_Homo sapiens_hsa005311.69994760
16Adherens junction_Homo sapiens_hsa045201.67962403
17Circadian rhythm_Homo sapiens_hsa047101.62768954
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.62764644
192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.60809678
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.57801640
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.53099250
22Renin secretion_Homo sapiens_hsa049241.51045244
23Small cell lung cancer_Homo sapiens_hsa052221.49991085
24Phenylalanine metabolism_Homo sapiens_hsa003601.46688837
25Histidine metabolism_Homo sapiens_hsa003401.44849325
26Malaria_Homo sapiens_hsa051441.43267884
27Ovarian steroidogenesis_Homo sapiens_hsa049131.41045438
28Viral myocarditis_Homo sapiens_hsa054161.39161219
29PI3K-Akt signaling pathway_Homo sapiens_hsa041511.38955973
30Arachidonic acid metabolism_Homo sapiens_hsa005901.37131479
31Other glycan degradation_Homo sapiens_hsa005111.36381756
32Aldosterone synthesis and secretion_Homo sapiens_hsa049251.33704796
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.33490583
34Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.32774766
35Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.18425780
36Hippo signaling pathway_Homo sapiens_hsa043901.18235639
37Glutathione metabolism_Homo sapiens_hsa004801.15729995
38Glucagon signaling pathway_Homo sapiens_hsa049221.14513401
39Complement and coagulation cascades_Homo sapiens_hsa046101.13225586
40Arginine biosynthesis_Homo sapiens_hsa002201.12267077
41Basal cell carcinoma_Homo sapiens_hsa052171.09021640
42Lysine degradation_Homo sapiens_hsa003101.08430176
43Sulfur metabolism_Homo sapiens_hsa009201.08109850
44Toxoplasmosis_Homo sapiens_hsa051451.05433078
45Oxytocin signaling pathway_Homo sapiens_hsa049211.04516977
46Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.04346920
47Mineral absorption_Homo sapiens_hsa049781.03783850
48Autoimmune thyroid disease_Homo sapiens_hsa053200.96749202
49Calcium signaling pathway_Homo sapiens_hsa040200.96012859
50GnRH signaling pathway_Homo sapiens_hsa049120.95579829
51Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.92417599
52Pathways in cancer_Homo sapiens_hsa052000.91164587
53Vascular smooth muscle contraction_Homo sapiens_hsa042700.88668177
54Hedgehog signaling pathway_Homo sapiens_hsa043400.85828141
55Arginine and proline metabolism_Homo sapiens_hsa003300.83694419
56Fructose and mannose metabolism_Homo sapiens_hsa000510.82244618
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.82144708
58Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.80733081
59Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.80512798
60Regulation of actin cytoskeleton_Homo sapiens_hsa048100.78177949
61Insulin resistance_Homo sapiens_hsa049310.76505374
62Cyanoamino acid metabolism_Homo sapiens_hsa004600.74726661
63Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.74143373
64Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.73373795
65Bile secretion_Homo sapiens_hsa049760.73352080
66Chemical carcinogenesis_Homo sapiens_hsa052040.73061007
67MicroRNAs in cancer_Homo sapiens_hsa052060.71788779
68Fatty acid degradation_Homo sapiens_hsa000710.71252170
69Circadian entrainment_Homo sapiens_hsa047130.70418030
70cAMP signaling pathway_Homo sapiens_hsa040240.68661975
71Prostate cancer_Homo sapiens_hsa052150.68306283
72Leukocyte transendothelial migration_Homo sapiens_hsa046700.67784464
73Starch and sucrose metabolism_Homo sapiens_hsa005000.66363713
74Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.65303537
75Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.64959429
76Rap1 signaling pathway_Homo sapiens_hsa040150.64749673
77Pyruvate metabolism_Homo sapiens_hsa006200.63780222
78TNF signaling pathway_Homo sapiens_hsa046680.63177734
79Pancreatic secretion_Homo sapiens_hsa049720.62850935
80Notch signaling pathway_Homo sapiens_hsa043300.62304173
81Estrogen signaling pathway_Homo sapiens_hsa049150.61108710
82cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60775961
83HIF-1 signaling pathway_Homo sapiens_hsa040660.60654173
84Apoptosis_Homo sapiens_hsa042100.60501215
85Tight junction_Homo sapiens_hsa045300.60411162
86Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60095701
87Sphingolipid metabolism_Homo sapiens_hsa006000.58770549
88Ras signaling pathway_Homo sapiens_hsa040140.58504341
89Galactose metabolism_Homo sapiens_hsa000520.57721842
90Pentose and glucuronate interconversions_Homo sapiens_hsa000400.57514943
91Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.56103392
92Pertussis_Homo sapiens_hsa051330.55492560
93Glioma_Homo sapiens_hsa052140.55409042
94Carbon metabolism_Homo sapiens_hsa012000.54057372
95Salivary secretion_Homo sapiens_hsa049700.53675845
96Long-term potentiation_Homo sapiens_hsa047200.52825539
97Chronic myeloid leukemia_Homo sapiens_hsa052200.52614832
98Vitamin digestion and absorption_Homo sapiens_hsa049770.51386080
99Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.51017305
100Fatty acid metabolism_Homo sapiens_hsa012120.50541549
101Axon guidance_Homo sapiens_hsa043600.50455125
102Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.50037687
103Thyroid cancer_Homo sapiens_hsa052160.49782302
104Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49681089
105Melanoma_Homo sapiens_hsa052180.48536735
106Insulin secretion_Homo sapiens_hsa049110.48410660
107Pancreatic cancer_Homo sapiens_hsa052120.48382667
108Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.48353112
109PPAR signaling pathway_Homo sapiens_hsa033200.48317079
110Glycerolipid metabolism_Homo sapiens_hsa005610.47617223
111Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.46161306
112Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46147129
113Wnt signaling pathway_Homo sapiens_hsa043100.46050073
114Renal cell carcinoma_Homo sapiens_hsa052110.45710593
115beta-Alanine metabolism_Homo sapiens_hsa004100.45644488
116Cholinergic synapse_Homo sapiens_hsa047250.45542828
117Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45209514
118Prion diseases_Homo sapiens_hsa050200.45050652
119Amphetamine addiction_Homo sapiens_hsa050310.45038480
120Long-term depression_Homo sapiens_hsa047300.44871707
121Dorso-ventral axis formation_Homo sapiens_hsa043200.44160003
122Tryptophan metabolism_Homo sapiens_hsa003800.43436385
123Phospholipase D signaling pathway_Homo sapiens_hsa040720.42571309
124Propanoate metabolism_Homo sapiens_hsa006400.42566722
125Fatty acid biosynthesis_Homo sapiens_hsa000610.42463428
126FoxO signaling pathway_Homo sapiens_hsa040680.40775766
127mTOR signaling pathway_Homo sapiens_hsa041500.40620811
128AMPK signaling pathway_Homo sapiens_hsa041520.40307322
129Gap junction_Homo sapiens_hsa045400.39713981
130Gastric acid secretion_Homo sapiens_hsa049710.39374786
131Insulin signaling pathway_Homo sapiens_hsa049100.38257682
132Type II diabetes mellitus_Homo sapiens_hsa049300.38141429
133Renin-angiotensin system_Homo sapiens_hsa046140.37346106
134Tyrosine metabolism_Homo sapiens_hsa003500.36990068
135Shigellosis_Homo sapiens_hsa051310.35473834
136Cardiac muscle contraction_Homo sapiens_hsa042600.34619826
137Thyroid hormone signaling pathway_Homo sapiens_hsa049190.34382525
138Central carbon metabolism in cancer_Homo sapiens_hsa052300.33940460
139Platelet activation_Homo sapiens_hsa046110.33850570
140Adipocytokine signaling pathway_Homo sapiens_hsa049200.33795884
141HTLV-I infection_Homo sapiens_hsa051660.33456216
142Melanogenesis_Homo sapiens_hsa049160.33118062
143Fat digestion and absorption_Homo sapiens_hsa049750.32598876
144Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.30966818

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