SMOX

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Polyamines are ubiquitous polycationic alkylamines which include spermine, spermidine, putrescine, and agmatine. These molecules participate in a broad range of cellular functions which include cell cycle modulation, scavenging reactive oxygen species, and the control of gene expression. These molecules also play important roles in neurotransmission through their regulation of cell-surface receptor activity, involvement in intracellular signalling pathways, and their putative roles as neurotransmitters. This gene encodes an FAD-containing enzyme that catalyzes the oxidation of spermine to spermadine and secondarily produces hydrogen peroxide. Multiple transcript variants encoding different isoenzymes have been identified for this gene, some of which have failed to demonstrate significant oxidase activity on natural polyamine substrates. The characterized isoenzymes have distinctive biochemical characteristics and substrate specificities, suggesting the existence of additional levels of complexity in polyamine catabolism. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1adenosine receptor signaling pathway (GO:0001973)4.65583585
2regulation of platelet activation (GO:0010543)4.31283850
3thrombin receptor signaling pathway (GO:0070493)4.21625561
4regulation of platelet aggregation (GO:0090330)4.19021760
5amino acid import (GO:0043090)4.18974823
6cyclooxygenase pathway (GO:0019371)3.90588855
7lipoxygenase pathway (GO:0019372)3.89757275
8negative regulation of platelet activation (GO:0010544)3.89751279
9negative regulation of homotypic cell-cell adhesion (GO:0034111)3.88446710
10protoporphyrinogen IX metabolic process (GO:0046501)3.87046020
11platelet aggregation (GO:0070527)3.75589810
12granulocyte activation (GO:0036230)3.72999537
13modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.72312869
14positive regulation by organism of defense response of other organism involved in symbiotic interact3.72312869
15modulation by symbiont of host immune response (GO:0052553)3.72312869
16positive regulation by symbiont of host defense response (GO:0052509)3.72312869
17modulation by symbiont of host defense response (GO:0052031)3.72312869
18modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.72312869
19angiogenesis involved in wound healing (GO:0060055)3.59694338
20negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.55680291
21neutrophil activation (GO:0042119)3.51663429
22layer formation in cerebral cortex (GO:0021819)3.50477123
23positive regulation of macrophage differentiation (GO:0045651)3.47761860
24positive regulation of mast cell activation (GO:0033005)3.47192324
25positive regulation of vasculogenesis (GO:2001214)3.43739621
26cellular response to thyroid hormone stimulus (GO:0097067)3.42904196
27response to methylmercury (GO:0051597)3.41995120
28endothelium development (GO:0003158)3.40577325
29regulation of integrin-mediated signaling pathway (GO:2001044)3.40541353
30protoporphyrinogen IX biosynthetic process (GO:0006782)3.37122035
31negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.33035754
32axon ensheathment in central nervous system (GO:0032291)3.30357306
33central nervous system myelination (GO:0022010)3.30357306
34regulation of integrin activation (GO:0033623)3.29264421
35response to peptidoglycan (GO:0032494)3.28261769
36L-amino acid import (GO:0043092)3.25939808
37positive regulation of dendritic spine morphogenesis (GO:0061003)3.20464970
38regulation of vitamin D biosynthetic process (GO:0060556)3.18428944
39platelet degranulation (GO:0002576)3.17216187
40regulation of mast cell degranulation (GO:0043304)3.14730577
41sodium-independent organic anion transport (GO:0043252)3.13688991
42positive regulation of receptor recycling (GO:0001921)3.12510532
43triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.09161752
44regulation of vasculogenesis (GO:2001212)3.06917072
45regulation of early endosome to late endosome transport (GO:2000641)3.06728709
46lipopolysaccharide-mediated signaling pathway (GO:0031663)3.03432012
47tolerance induction (GO:0002507)3.02578975
48negative regulation of thymocyte apoptotic process (GO:0070244)3.02062725
49regulation of homotypic cell-cell adhesion (GO:0034110)2.97792395
50cellular response to cholesterol (GO:0071397)2.96440147
51positive regulation of p38MAPK cascade (GO:1900745)2.95087011
52low-density lipoprotein particle remodeling (GO:0034374)2.94245312
53regulation of podosome assembly (GO:0071801)2.93838222
54creatine metabolic process (GO:0006600)2.93340695
55erythrocyte maturation (GO:0043249)2.92686379
56serine transport (GO:0032329)2.91467716
57negative regulation of erythrocyte differentiation (GO:0045647)2.90444486
58regulation of leukocyte degranulation (GO:0043300)2.90261176
59regulation of mast cell activation involved in immune response (GO:0033006)2.89925557
60L-serine transport (GO:0015825)2.86653635
61microglial cell activation (GO:0001774)2.86306333
62positive regulation of endothelial cell differentiation (GO:0045603)2.85808065
63positive regulation of astrocyte differentiation (GO:0048711)2.85729798
64negative regulation of lipid storage (GO:0010888)2.84745210
65leukocyte aggregation (GO:0070486)2.84620858
66mesodermal cell differentiation (GO:0048333)2.84098117
67positive regulation of mast cell activation involved in immune response (GO:0033008)2.83441200
68positive regulation of mast cell degranulation (GO:0043306)2.83441200
69regulation of p38MAPK cascade (GO:1900744)2.82834015
70Notch signaling involved in heart development (GO:0061314)2.82578873
71regulation of somitogenesis (GO:0014807)2.81203229
72G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.79939845
73lymph vessel development (GO:0001945)2.79491275
74leukocyte migration involved in inflammatory response (GO:0002523)2.78940619
75regulation of myeloid leukocyte mediated immunity (GO:0002886)2.78210052
76negative regulation of focal adhesion assembly (GO:0051895)2.77890368
77negative regulation of cell junction assembly (GO:1901889)2.77890368
78negative regulation of adherens junction organization (GO:1903392)2.77890368
79regulation of memory T cell differentiation (GO:0043380)2.77683311
80negative regulation of interleukin-12 production (GO:0032695)2.75819976
81regulation of vitamin metabolic process (GO:0030656)2.75559341
82protein localization to endosome (GO:0036010)2.74887853
83blood coagulation, intrinsic pathway (GO:0007597)2.74793348
84platelet activation (GO:0030168)2.73977980
85response to laminar fluid shear stress (GO:0034616)2.72374057
86response to magnesium ion (GO:0032026)2.70183804
87L-alpha-amino acid transmembrane transport (GO:1902475)2.70070068
88positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.69899451
89homotypic cell-cell adhesion (GO:0034109)2.69800249
90positive regulation of leukocyte degranulation (GO:0043302)2.68903292
91neutral amino acid transport (GO:0015804)2.68465640
92cellular response to sterol (GO:0036315)2.68180193
93regulation of mononuclear cell migration (GO:0071675)2.66673688
94modulation by symbiont of host cellular process (GO:0044068)2.66605048
95regulation of mast cell activation (GO:0033003)2.66573172
96macrophage activation involved in immune response (GO:0002281)2.66009556
97cellular response to arsenic-containing substance (GO:0071243)2.65508714
98positive regulation of interleukin-17 production (GO:0032740)2.65273798
99regulation of T-helper 1 cell differentiation (GO:0045625)2.64975016
100positive regulation of blood coagulation (GO:0030194)2.64880180
101positive regulation of hemostasis (GO:1900048)2.64880180
102positive regulation of cellular amide metabolic process (GO:0034250)2.64808712
103positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.64675380
104positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.64643134
105negative regulation of cytokine production involved in immune response (GO:0002719)2.64017250
106regulation of macrophage derived foam cell differentiation (GO:0010743)2.63973211
107stress fiber assembly (GO:0043149)2.63840808
108positive regulation of cAMP-mediated signaling (GO:0043950)2.63374781
109regulation of chronic inflammatory response (GO:0002676)2.62087608
110endothelial cell differentiation (GO:0045446)2.61598982
111protein neddylation (GO:0045116)2.61354631
112membrane invagination (GO:0010324)2.61143117
113decidualization (GO:0046697)2.60598928
114glycosphingolipid catabolic process (GO:0046479)2.59618110
115positive regulation of coagulation (GO:0050820)2.58690400
116phagocytosis, engulfment (GO:0006911)2.58659837
117signal complex assembly (GO:0007172)2.58179112
118import into cell (GO:0098657)2.58105518
119positive regulation of neurotransmitter secretion (GO:0001956)2.57508810
120peptidyl-tyrosine autophosphorylation (GO:0038083)2.54468124
121negative regulation of interleukin-10 production (GO:0032693)2.54078827
122response to muramyl dipeptide (GO:0032495)2.51430108
123response to cholesterol (GO:0070723)2.51294172
124heme biosynthetic process (GO:0006783)2.50859000
125response to thyroid hormone (GO:0097066)2.49227660
126ensheathment of neurons (GO:0007272)2.48998793
127axon ensheathment (GO:0008366)2.48998793
128purinergic receptor signaling pathway (GO:0035587)2.48811954
129regulation of sensory perception (GO:0051931)2.47883801
130regulation of sensory perception of pain (GO:0051930)2.47883801
131peptide catabolic process (GO:0043171)2.47221599
132myeloid cell activation involved in immune response (GO:0002275)2.47130291
133positive regulation of monocyte chemotaxis (GO:0090026)2.47125529
134germ cell migration (GO:0008354)2.47100809
135hemoglobin metabolic process (GO:0020027)2.46882957
136positive regulation of toll-like receptor signaling pathway (GO:0034123)2.46691586
137regulation of interferon-beta biosynthetic process (GO:0045357)2.46462016
138cortical actin cytoskeleton organization (GO:0030866)2.46219795
139positive regulation of Rho protein signal transduction (GO:0035025)2.44405986
140regulation of MHC class II biosynthetic process (GO:0045346)2.43953876
141positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.43796783
142negative regulation of interleukin-17 production (GO:0032700)2.42704413
143regulation of mitochondrial depolarization (GO:0051900)2.42516417
144adhesion of symbiont to host cell (GO:0044650)2.39977528
145virion attachment to host cell (GO:0019062)2.39977528
146porphyrin-containing compound biosynthetic process (GO:0006779)2.39797614
147regulation of cholesterol efflux (GO:0010874)2.39743330
148regulation of receptor recycling (GO:0001919)2.39206938
149regulation of activation of Janus kinase activity (GO:0010533)2.39015280
150protein kinase B signaling (GO:0043491)2.38894293
151myelination (GO:0042552)2.38878377
152positive regulation of systemic arterial blood pressure (GO:0003084)2.38353761
153regulation of cytokine secretion involved in immune response (GO:0002739)2.37889543
154response to sterol (GO:0036314)2.37523678
155T-helper 1 type immune response (GO:0042088)2.35878388
156negative regulation of norepinephrine secretion (GO:0010700)2.35643222
157regulation of norepinephrine secretion (GO:0014061)2.35391945
158fibrinolysis (GO:0042730)2.35101784
159modulation by virus of host process (GO:0019054)2.34708027
160negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.33899754
161response to host immune response (GO:0052572)2.33898071
162response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.33898071
163cytoskeletal anchoring at plasma membrane (GO:0007016)2.33532719
164cortical cytoskeleton organization (GO:0030865)2.33007408
165regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.32419760
166negative regulation of protein localization to plasma membrane (GO:1903077)2.31611767
167positive regulation of type 2 immune response (GO:0002830)2.31532828
168nucleotide transmembrane transport (GO:1901679)2.30058203
169activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.29845750
170cellular extravasation (GO:0045123)2.28577559
171negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.27163930
172neutrophil activation involved in immune response (GO:0002283)2.27127254
173vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.27036675
174regulation of membrane protein ectodomain proteolysis (GO:0051043)2.26985304
175response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.26876496
176response to host (GO:0075136)2.26876496
177response to host defenses (GO:0052200)2.26876496
178positive regulation of T-helper 1 type immune response (GO:0002827)2.26860477
179hemidesmosome assembly (GO:0031581)2.26201915
180keratan sulfate biosynthetic process (GO:0018146)2.26063582
181myeloid cell development (GO:0061515)2.25772445
182response to lead ion (GO:0010288)2.23956603
183positive regulation of chemokine biosynthetic process (GO:0045080)2.22250513
184response to lipoprotein particle (GO:0055094)2.21773272
185blood vessel maturation (GO:0001955)2.21753880
186protein targeting to plasma membrane (GO:0072661)2.21159213
187trabecula morphogenesis (GO:0061383)2.19380980
188positive regulation of T-helper cell differentiation (GO:0045624)2.18215171
189regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.17591690
190regulation of interleukin-17 production (GO:0032660)2.16347252
191regulation of T-helper 2 cell differentiation (GO:0045628)2.16051027
192cell adhesion mediated by integrin (GO:0033627)2.15857121
193iron ion import (GO:0097286)2.15822366

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human3.26027460
2TRIM28_21343339_ChIP-Seq_HEK293_Human2.99370067
3STAT6_21828071_ChIP-Seq_BEAS2B_Human2.97632071
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.88163838
5RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.87776255
6ZNF263_19887448_ChIP-Seq_K562_Human2.82908030
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.78527694
8LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.70262620
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.63873848
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.50969319
11GATA1_19941826_ChIP-Seq_K562_Human2.47671099
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.25624689
13KDM2B_26808549_Chip-Seq_SUP-B15_Human2.23203563
14* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.15664229
15LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.06867633
16CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.05516878
17ESR2_21235772_ChIP-Seq_MCF-7_Human2.02745865
18* KDM2B_26808549_Chip-Seq_DND41_Human1.98857321
19SRY_22984422_ChIP-ChIP_TESTIS_Rat1.95963532
20RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.93632039
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.92727220
22MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.88391728
23* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.87537683
24KDM2B_26808549_Chip-Seq_K562_Human1.86216226
25SCL_19346495_ChIP-Seq_HPC-7_Human1.85306733
26RUNX_20019798_ChIP-Seq_JUKART_Human1.82230022
27NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.80734927
28GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.79780940
29* ELK3_25401928_ChIP-Seq_HUVEC_Human1.78131506
30RARG_19884340_ChIP-ChIP_MEFs_Mouse1.74209251
31SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.73514270
32GATA1_22383799_ChIP-Seq_G1ME_Mouse1.72885709
33GATA2_19941826_ChIP-Seq_K562_Human1.60832433
34KDM2B_26808549_Chip-Seq_JURKAT_Human1.60780341
35KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.56582866
36* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.55915641
37IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.55399824
38THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.52363835
39TCF7_22412390_ChIP-Seq_EML_Mouse1.52119648
40* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.49215494
41IRF8_27001747_Chip-Seq_BMDM_Mouse1.47929971
42HIF1A_21447827_ChIP-Seq_MCF-7_Human1.47178319
43LXR_22292898_ChIP-Seq_THP-1_Human1.44761786
44* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.44411578
45ESR1_21235772_ChIP-Seq_MCF-7_Human1.43657122
46* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.42513061
47MAF_26560356_Chip-Seq_TH1_Human1.41326360
48IKZF1_21737484_ChIP-ChIP_HCT116_Human1.41256237
49VDR_24763502_ChIP-Seq_THP-1_Human1.40071190
50ESR1_20079471_ChIP-ChIP_T-47D_Human1.39800185
51* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.39259248
52VDR_21846776_ChIP-Seq_THP-1_Human1.39039400
53KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.38300371
54KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.38300371
55KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.38300371
56CDX2_19796622_ChIP-Seq_MESCs_Mouse1.37394417
57GATA1_19941827_ChIP-Seq_MEL_Mouse1.35868755
58STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.35818159
59P300_27058665_Chip-Seq_ZR-75-30cells_Human1.34421471
60* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.33844488
61RACK7_27058665_Chip-Seq_MCF-7_Human1.33711483
62NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.33300932
63PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.32318322
64VDR_24787735_ChIP-Seq_THP-1_Human1.31210746
65CTCF_27219007_Chip-Seq_ERYTHROID_Human1.30552851
66E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.29693993
67TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.29500424
68BRD4_27068464_Chip-Seq_AML-cells_Mouse1.27559667
69P63_26484246_Chip-Seq_KERATINOCYTES_Human1.25372236
70* KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.24644959
71HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.24202166
72IRF8_21731497_ChIP-ChIP_J774_Mouse1.23340174
73NCOR1_26117541_ChIP-Seq_K562_Human1.20786645
74MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.19858793
75TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.19850748
76CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19553045
77ERG_21242973_ChIP-ChIP_JURKAT_Human1.19359617
78FOXO3_23340844_ChIP-Seq_DLD1_Human1.18484153
79GATA2_21666600_ChIP-Seq_HMVEC_Human1.18437510
80KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.18314538
81* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.16787134
82STAT4_19710469_ChIP-ChIP_TH1__Mouse1.16428375
83HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.16133974
84VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.15507488
85RXR_22158963_ChIP-Seq_LIVER_Mouse1.15163605
86PPAR_26484153_Chip-Seq_NCI-H1993_Human1.14974878
87RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14856032
88IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.14710578
89IRF8_22096565_ChIP-ChIP_GC-B_Human1.14050357
90CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13949571
91NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.13809604
92CLOCK_20551151_ChIP-Seq_293T_Human1.13177813
93UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.12535794
94WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.12435366
95GATA2_22383799_ChIP-Seq_G1ME_Mouse1.11548991
96MTF2_20144788_ChIP-Seq_MESCs_Mouse1.10979169
97GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09831279
98CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.09090056
99SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.07875721
100SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.07220576
101PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.07000930
102ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.06641736
103PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06516821
104SPI1_23127762_ChIP-Seq_K562_Human1.06109848
105SOX2_20726797_ChIP-Seq_SW620_Human1.05926539
106CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05835960
107BCOR_27268052_Chip-Seq_Bcells_Human1.05734355
108CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05432463
109TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.05335275
110SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04529955
111SMC1_22415368_ChIP-Seq_MEFs_Mouse1.03977497
112ELF1_20517297_ChIP-Seq_JURKAT_Human1.03611779
113RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.02674777
114KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.02297196
115* SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.02048607
116SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.01890711
117GATA1_19941827_ChIP-Seq_MEL86_Mouse1.01698415
118* WT1_19549856_ChIP-ChIP_CCG9911_Human1.01556101
119CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.00945198
120PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00657504
121* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00432687
122AR_21572438_ChIP-Seq_LNCaP_Human0.99946413
123RUNX1_22412390_ChIP-Seq_EML_Mouse0.99894206
124EZH2_18974828_ChIP-Seq_MESCs_Mouse0.99834409
125RNF2_18974828_ChIP-Seq_MESCs_Mouse0.99834409
126UTX_26944678_Chip-Seq_JUKART_Human0.98864572
127SUZ12_27294783_Chip-Seq_ESCs_Mouse0.98084392
128KLF5_25053715_ChIP-Seq_YYC3_Human0.97311990
129BCL6_27268052_Chip-Seq_Bcells_Human0.96908267
130DNAJC2_21179169_ChIP-ChIP_NT2_Human0.96733562
131EGR1_19374776_ChIP-ChIP_THP-1_Human0.96619532
132SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.95389224
133ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.94347815
134ELK4_26923725_Chip-Seq_MESODERM_Mouse0.94045362
135SPI1_23547873_ChIP-Seq_NB4_Human0.93705277
136EED_16625203_ChIP-ChIP_MESCs_Mouse0.92783803
137PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.92569045
138SMAD_19615063_ChIP-ChIP_OVARY_Human0.92359357
139ZFP281_27345836_Chip-Seq_ESCs_Mouse0.91953232
140UBF1/2_26484160_Chip-Seq_HMECs_Human0.91181926
141PU_27001747_Chip-Seq_BMDM_Mouse0.91090224
142CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89911280
143* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.88250654

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003656_abnormal_erythrocyte_physiolo4.23130942
2MP0008004_abnormal_stomach_pH4.09679442
3MP0003303_peritoneal_inflammation3.18529373
4MP0005167_abnormal_blood-brain_barrier2.90792994
5MP0004147_increased_porphyrin_level2.60888090
6MP0005623_abnormal_meninges_morphology2.59159680
7MP0009278_abnormal_bone_marrow2.43043832
8MP0005171_absent_coat_pigmentation2.34309410
9MP0000685_abnormal_immune_system2.21092169
10MP0003690_abnormal_glial_cell2.11467728
11MP0000920_abnormal_myelination2.09453231
12MP0003724_increased_susceptibility_to2.01129621
13MP0003436_decreased_susceptibility_to1.97421415
14MP0003453_abnormal_keratinocyte_physiol1.95657459
15MP0003300_gastrointestinal_ulcer1.94328690
16MP0003075_altered_response_to1.91070099
17MP0000343_altered_response_to1.87328191
18MP0000465_gastrointestinal_hemorrhage1.81506137
19MP0004272_abnormal_basement_membrane1.75518659
20MP0003191_abnormal_cellular_cholesterol1.73372526
21MP0009785_altered_susceptibility_to1.71060734
22MP0002405_respiratory_system_inflammati1.68307266
23MP0002139_abnormal_hepatobiliary_system1.65341058
24MP0001879_abnormal_lymphatic_vessel1.64942079
25MP0002419_abnormal_innate_immunity1.64255098
26MP0001835_abnormal_antigen_presentation1.64192483
27MP0005000_abnormal_immune_tolerance1.62640414
28MP0005165_increased_susceptibility_to1.61950649
29MP0003828_pulmonary_edema1.60282723
30MP0001533_abnormal_skeleton_physiology1.60213864
31MP0000858_altered_metastatic_potential1.58094759
32MP0005058_abnormal_lysosome_morphology1.57862827
33MP0004858_abnormal_nervous_system1.56186226
34MP0008260_abnormal_autophagy1.53601006
35MP0004510_myositis1.52717053
36MP0006082_CNS_inflammation1.51695827
37MP0002332_abnormal_exercise_endurance1.46625311
38MP0006054_spinal_hemorrhage1.45169226
39MP0005025_abnormal_response_to1.42000682
40MP0001849_ear_inflammation1.39435172
41MP0005387_immune_system_phenotype1.38686850
42MP0001790_abnormal_immune_system1.38686850
43MP0005083_abnormal_biliary_tract1.37050421
44MP0000733_abnormal_muscle_development1.36486916
45MP0003091_abnormal_cell_migration1.35738020
46MP0002148_abnormal_hypersensitivity_rea1.34023792
47MP0004947_skin_inflammation1.33582358
48MP0004145_abnormal_muscle_electrophysio1.32805619
49MP0002933_joint_inflammation1.31663314
50MP0003634_abnormal_glial_cell1.31522832
51MP0002998_abnormal_bone_remodeling1.28004535
52MP0008874_decreased_physiological_sensi1.25521789
53MP0003879_abnormal_hair_cell1.23171089
54MP0000749_muscle_degeneration1.22093426
55MP0010678_abnormal_skin_adnexa1.22068836
56MP0003172_abnormal_lysosome_physiology1.21525797
57MP0000747_muscle_weakness1.20473914
58MP0002736_abnormal_nociception_after1.20207010
59MP0001851_eye_inflammation1.20086244
60MP0005671_abnormal_response_to1.19305461
61MP0000604_amyloidosis1.18455068
62MP0003566_abnormal_cell_adhesion1.18057355
63MP0002452_abnormal_antigen_presenting1.17379858
64MP0003329_amyloid_beta_deposits1.17175169
65MP0001545_abnormal_hematopoietic_system1.16452901
66MP0005397_hematopoietic_system_phenotyp1.16452901
67MP0005164_abnormal_response_to1.16106682
68MP0002723_abnormal_immune_serum1.12533042
69MP0010155_abnormal_intestine_physiology1.11302776
70MP0001819_abnormal_immune_cell1.09752485
71MP0003279_aneurysm1.08723787
72MP0002420_abnormal_adaptive_immunity1.08622039
73MP0009763_increased_sensitivity_to1.07023784
74MP0009764_decreased_sensitivity_to1.06433231
75MP0000383_abnormal_hair_follicle1.04161967
76MP0005390_skeleton_phenotype1.03652129
77MP0009840_abnormal_foam_cell1.00326943
78MP0009765_abnormal_xenobiotic_induced0.99925200
79MP0005451_abnormal_body_composition0.99301130
80MP0005464_abnormal_platelet_physiology0.98889873
81MP0001663_abnormal_digestive_system0.98515871
82MP0003448_altered_tumor_morphology0.97636207
83MP0002282_abnormal_trachea_morphology0.96472848
84MP0009333_abnormal_splenocyte_physiolog0.94564035
85MP0004484_altered_response_of0.94534834
86MP0001542_abnormal_bone_strength0.92709759
87MP0002877_abnormal_melanocyte_morpholog0.92656656
88MP0001853_heart_inflammation0.92647596
89MP0000230_abnormal_systemic_arterial0.92448943
90MP0008469_abnormal_protein_level0.92244567
91MP0002254_reproductive_system_inflammat0.91720593
92MP0000750_abnormal_muscle_regeneration0.90601013
93MP0002295_abnormal_pulmonary_circulatio0.90473823
94MP0005076_abnormal_cell_differentiation0.89358051
95MP0003136_yellow_coat_color0.86843587
96MP0001958_emphysema0.86247846
97MP0001800_abnormal_humoral_immune0.86124540
98MP0000249_abnormal_blood_vessel0.85250078
99MP0003045_fibrosis0.84308870
100MP0002106_abnormal_muscle_physiology0.83997633
101MP0003638_abnormal_response/metabolism_0.82940627
102MP0003705_abnormal_hypodermis_morpholog0.82783700
103MP0005166_decreased_susceptibility_to0.82401510
104MP0001346_abnormal_lacrimal_gland0.82224936
105MP0005365_abnormal_bile_salt0.82158459
106MP0004130_abnormal_muscle_cell0.81958837
107MP0004185_abnormal_adipocyte_glucose0.81843814
108MP0005410_abnormal_fertilization0.81213560
109MP0008438_abnormal_cutaneous_collagen0.80369114
110MP0010234_abnormal_vibrissa_follicle0.80281567
111MP0003186_abnormal_redox_activity0.80204438
112MP0002398_abnormal_bone_marrow0.80190909
113MP0005595_abnormal_vascular_smooth0.79460120
114MP0003633_abnormal_nervous_system0.79297034
115MP0000759_abnormal_skeletal_muscle0.79052959
116MP0000767_abnormal_smooth_muscle0.78914660
117MP0004885_abnormal_endolymph0.78754881
118MP0003795_abnormal_bone_structure0.78514564
119MP0005023_abnormal_wound_healing0.78472072
120MP0008569_lethality_at_weaning0.78197231
121MP0001299_abnormal_eye_distance/0.78186933
122MP0002733_abnormal_thermal_nociception0.77785005
123MP0001845_abnormal_inflammatory_respons0.77744813
124MP0005620_abnormal_muscle_contractility0.76330419
125MP0003646_muscle_fatigue0.76212942
126MP0002429_abnormal_blood_cell0.73826554
127MP0005310_abnormal_salivary_gland0.73183122
128MP0001968_abnormal_touch/_nociception0.71877709
129MP0000716_abnormal_immune_system0.71160784
130MP0001970_abnormal_pain_threshold0.69475472
131MP0005666_abnormal_adipose_tissue0.65686472
132MP0002089_abnormal_postnatal_growth/wei0.61904218
133MP0005381_digestive/alimentary_phenotyp0.60574598
134MP0004883_abnormal_blood_vessel0.59426142
135MP0005501_abnormal_skin_physiology0.59180350
136MP0002653_abnormal_ependyma_morphology0.58332372
137MP0001915_intracranial_hemorrhage0.58166122
138MP0002722_abnormal_immune_system0.56722342

Predicted human phenotypes

RankGene SetZ-score
1Petechiae (HP:0000967)7.51186604
2Prolonged bleeding time (HP:0003010)7.42774332
3Purpura (HP:0000979)7.17714248
4Menorrhagia (HP:0000132)6.94472039
5Increased mean platelet volume (HP:0011877)6.77583532
6Abnormal platelet volume (HP:0011876)6.44133834
7Exercise-induced muscle cramps (HP:0003710)6.00466992
8Epistaxis (HP:0000421)5.42271723
9Gingival bleeding (HP:0000225)4.73492436
10Abnormal platelet function (HP:0011869)4.27397052
11Impaired platelet aggregation (HP:0003540)4.27397052
12Abnormality of liposaccharide metabolism (HP:0010968)4.11289971
13Abnormality of glycosphingolipid metabolism (HP:0004343)4.11289971
14Abnormality of glycolipid metabolism (HP:0010969)4.11289971
15Paralysis (HP:0003470)3.77332978
16Round ear (HP:0100830)3.57477200
17Abnormality of binocular vision (HP:0011514)3.48312432
18Diplopia (HP:0000651)3.48312432
19Onycholysis (HP:0001806)3.36400651
20Vacuolated lymphocytes (HP:0001922)3.29804839
21Muscle stiffness (HP:0003552)3.22549305
22Abnormality of the vasculature of the conjunctiva (HP:0008054)3.20499848
23Spontaneous hematomas (HP:0007420)3.17252403
24Exercise-induced myalgia (HP:0003738)3.06312470
25Conjunctival telangiectasia (HP:0000524)2.95405911
26Reticulocytosis (HP:0001923)2.92366920
27Hyperlipoproteinemia (HP:0010980)2.91312987
28Hepatosplenomegaly (HP:0001433)2.87422511
29Increased serum ferritin (HP:0003281)2.86396836
30Neurofibrillary tangles (HP:0002185)2.83819237
31Pustule (HP:0200039)2.83647283
32Eczematoid dermatitis (HP:0000976)2.82383495
33Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.78998515
34Diaphragmatic weakness (HP:0009113)2.77117271
35Systemic lupus erythematosus (HP:0002725)2.73664790
36Abnormality of the common coagulation pathway (HP:0010990)2.72012527
37Thick nail (HP:0001805)2.71427493
38Difficulty running (HP:0009046)2.71374614
39Milia (HP:0001056)2.70017694
40Loss of speech (HP:0002371)2.66507430
41Recurrent abscess formation (HP:0002722)2.63927870
42Bruising susceptibility (HP:0000978)2.62429237
43Poikilocytosis (HP:0004447)2.60358608
44Polycythemia (HP:0001901)2.59703914
45Myocardial infarction (HP:0001658)2.59412663
46Increased cerebral lipofuscin (HP:0011813)2.58996110
47Amyloidosis (HP:0011034)2.55600166
48Nuclear cataract (HP:0100018)2.54263536
49Muscle fiber inclusion bodies (HP:0100299)2.54133438
50Orchitis (HP:0100796)2.52564823
51Myositis (HP:0100614)2.52007195
52Abnormality of iron homeostasis (HP:0011031)2.49990920
53Abnormality of the heme biosynthetic pathway (HP:0010472)2.48851707
54Stomatitis (HP:0010280)2.45516137
55Abnormality of lateral ventricle (HP:0030047)2.44159761
56Dysostosis multiplex (HP:0000943)2.44089219
57Optic neuritis (HP:0100653)2.42356271
58Retrobulbar optic neuritis (HP:0100654)2.42356271
59Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.42023776
60Increased neuronal autofluorescent lipopigment (HP:0002074)2.39539502
61Mutism (HP:0002300)2.38656118
62Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.35705658
63Premature rupture of membranes (HP:0001788)2.35340859
64Epiphyseal dysplasia (HP:0002656)2.35248127
65Arterial tortuosity (HP:0005116)2.29039892
66Choroideremia (HP:0001139)2.28600334
67Pancreatic islet-cell hyperplasia (HP:0004510)2.27065247
68Atrophic scars (HP:0001075)2.26944945
69Hypoplasia of the iris (HP:0007676)2.25551946
70Episodic fever (HP:0001954)2.25237154
71Cerebral inclusion bodies (HP:0100314)2.22715957
72Disinhibition (HP:0000734)2.21651717
73Muscle hypertrophy of the lower extremities (HP:0008968)2.20668517
74Hypoplastic ischia (HP:0003175)2.19701775
75Abnormality of proline metabolism (HP:0010907)2.18464317
76Hydroxyprolinuria (HP:0003080)2.18464317
77Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.17686222
78Myopathic facies (HP:0002058)2.17293085
79Upper limb muscle weakness (HP:0003484)2.15729546
80Prolonged neonatal jaundice (HP:0006579)2.15407237
81Abnormality of the Achilles tendon (HP:0005109)2.15056888
82Hemiparesis (HP:0001269)2.14877384
83Calcaneovalgus deformity (HP:0001848)2.14274493
84Nemaline bodies (HP:0003798)2.13934375
85Aplasia involving bones of the upper limbs (HP:0009823)2.13533386
86Aplasia of the phalanges of the hand (HP:0009802)2.13533386
87Aplasia involving bones of the extremities (HP:0009825)2.13533386
88Acanthocytosis (HP:0001927)2.12818400
89Distal lower limb amyotrophy (HP:0008944)2.12431072
90Xanthomatosis (HP:0000991)2.11590039
91Peripheral hypomyelination (HP:0007182)2.10397128
92Distal arthrogryposis (HP:0005684)2.08764867
93Chronic obstructive pulmonary disease (HP:0006510)2.08245140
94Obstructive lung disease (HP:0006536)2.08245140
95Increased IgM level (HP:0003496)2.07634657
96Abnormality of transition element cation homeostasis (HP:0011030)2.07077000
97Premature skin wrinkling (HP:0100678)2.03608036
98Vascular tortuosity (HP:0004948)2.03323881
99Abnormality of the ischium (HP:0003174)2.03142936
100Type 1 muscle fiber predominance (HP:0003803)2.01972951
101Apathy (HP:0000741)2.00790855
102Muscle fiber splitting (HP:0003555)2.00174899
103Neuronal loss in central nervous system (HP:0002529)1.99304120
104Elevated erythrocyte sedimentation rate (HP:0003565)1.98981202
105Hyporeflexia of lower limbs (HP:0002600)1.98890257
106Axonal loss (HP:0003447)1.98412402
107Scapular winging (HP:0003691)1.97770965
108Fragile nails (HP:0001808)1.96352982
109Deformed tarsal bones (HP:0008119)1.94307153
110Adactyly (HP:0009776)1.93682985
111Cholecystitis (HP:0001082)1.93319240
112Abnormal gallbladder physiology (HP:0012438)1.93319240
113Supranuclear gaze palsy (HP:0000605)1.93101074
114Diminished motivation (HP:0000745)1.92419466
115Nausea (HP:0002018)1.92107433
116Abnormal pupillary function (HP:0007686)1.90055508
117Abnormality of macrophages (HP:0004311)1.88917056
118Mucopolysacchariduria (HP:0008155)1.88152100
119Urinary glycosaminoglycan excretion (HP:0003541)1.88152100
120Autoimmune thrombocytopenia (HP:0001973)1.87865533
121Cholelithiasis (HP:0001081)1.87617948
122Ulnar deviation of the wrist (HP:0003049)1.87391399
123Hemorrhage of the eye (HP:0011885)1.86851016
124Joint swelling (HP:0001386)1.86794018
125Increased CSF protein (HP:0002922)1.84293162
126Tetraparesis (HP:0002273)1.83789513
127Vertigo (HP:0002321)1.82232169
128Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.81409276
129Hypochromic microcytic anemia (HP:0004840)1.79096861
130Clumsiness (HP:0002312)1.78935456
131Hematochezia (HP:0002573)1.78533550
132Dysautonomia (HP:0002459)1.76596942
133Calf muscle hypertrophy (HP:0008981)1.75217486
134Bone pain (HP:0002653)1.74739321
135Glomerulonephritis (HP:0000099)1.74183719
136Basal ganglia calcification (HP:0002135)1.73564907
137Urticaria (HP:0001025)1.73485319
138Absent hand (HP:0004050)1.72648503
139Joint hemorrhage (HP:0005261)1.70341792
140Osteolytic defects of the hand bones (HP:0009699)1.70114501
141Osteolytic defects of the phalanges of the hand (HP:0009771)1.70114501
142EMG: myopathic abnormalities (HP:0003458)1.69697297
143Dementia (HP:0000726)1.69308321
144Cerebral aneurysm (HP:0004944)1.68590490
145Abnormal gallbladder morphology (HP:0012437)1.68419891
146Aortic dissection (HP:0002647)1.67389367
147Mediastinal lymphadenopathy (HP:0100721)1.66827756
148Lower limb amyotrophy (HP:0007210)1.66683766
149Achilles tendon contracture (HP:0001771)1.66664178
150J-shaped sella turcica (HP:0002680)1.66596573
151Dyschromatopsia (HP:0007641)1.66277850
152Arterial thrombosis (HP:0004420)1.65998822
153Increased variability in muscle fiber diameter (HP:0003557)1.65231009
154Recurrent bacterial skin infections (HP:0005406)1.63735536
155Abnormality of skeletal muscle fiber size (HP:0012084)1.61025622
156Megalencephaly (HP:0001355)1.60984761
157Fragile skin (HP:0001030)1.60563612
158Parakeratosis (HP:0001036)1.59731836
159Increased density of long bones (HP:0006392)1.58462282
160Abnormality of mucopolysaccharide metabolism (HP:0011020)1.58169878
161Abnormality of polysaccharide metabolism (HP:0011012)1.58169878
162Abnormality of glycosaminoglycan metabolism (HP:0004371)1.58169878
163Vertebral compression fractures (HP:0002953)1.57515816
164Onion bulb formation (HP:0003383)1.56955489
165Segmental peripheral demyelination/remyelination (HP:0003481)1.55906715

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB13.46627813
2KDR3.44605452
3FGR2.77158365
4TAOK22.67684274
5TBK12.66291708
6ARAF2.50969920
7TRIB32.22818142
8LMTK22.15720800
9NME22.08985772
10EEF2K2.08559641
11EIF2AK12.07585370
12BMX2.04302689
13MAPKAPK52.02550542
14DDR21.97821878
15PHKG21.86916321
16PHKG11.86916321
17TRPM71.73113087
18MST41.64392809
19MAP3K111.59850402
20PRPF4B1.58706317
21TGFBR21.57794215
22RIPK11.53822687
23CSF1R1.53563940
24MAP2K21.53308890
25IKBKE1.51157921
26TTN1.48442823
27MAPK151.46405443
28CSK1.45823523
29PIM21.44253430
30ICK1.41816827
31TYRO31.39285110
32ABL21.38833865
33CAMK1G1.37543126
34FES1.33471051
35BMPR21.33322426
36GRK51.33319090
37MAP3K141.30725001
38IRAK41.30454938
39STK101.29743287
40GRK71.27423969
41EPHA21.25971384
42SYK1.23333013
43MATK1.22871905
44DMPK1.19025075
45NTRK21.15138464
46MYLK1.13778620
47TAOK11.12660458
48BTK1.12617990
49ERN11.12058140
50ADRBK21.11235486
51DYRK1B1.10751525
52TEC1.08327159
53IRAK11.05388216
54IKBKB1.02340390
55GRK61.02179947
56MUSK1.00920996
57SIK11.00394902
58KSR20.98585237
59MAPK120.97855093
60IRAK30.97456979
61TYK20.95866567
62LRRK20.95382143
63CDC42BPA0.94589830
64BLK0.94309690
65ILK0.92519493
66LATS20.91663178
67EPHA30.91659230
68MAP3K100.90781142
69MAPKAPK30.90490915
70TESK10.88780695
71TESK20.88190503
72MAP3K30.87610360
73PDGFRA0.86307390
74PTK2B0.84838199
75IRAK20.83127689
76JAK10.81428670
77MAP3K90.81333694
78PAK10.80835827
79PRKAA20.80772431
80PIM10.80460541
81MAP3K50.79756657
82PAK40.79555142
83NTRK10.78422068
84DAPK20.77343880
85PDPK10.77130403
86STK390.76751162
87PNCK0.75702839
88DAPK30.75155717
89MAP2K30.74585003
90MAP3K10.74331322
91MET0.72394632
92MAP4K10.72271956
93MOS0.71301777
94WNK10.71277168
95TAOK30.69598148
96PTK60.68813839
97PRKG20.68691898
98GSK3A0.68371549
99PKN10.68246527
100TNK20.68012850
101BRAF0.67966030
102PDGFRB0.66514713
103MAP2K10.66346902
104UHMK10.64229387
105PDK10.62388290
106ALK0.62087444
107JAK30.61251592
108JAK20.59358550
109ZAP700.58787258
110MAPKAPK20.58492845
111RIPK40.58120172
112HCK0.58022218
113OBSCN0.57895034
114CAMK2G0.57724312
115SIK30.57167874
116LCK0.56671421
117LYN0.55590282
118CLK10.55490038
119EGFR0.53388003
120PTK20.52655301
121MST1R0.51117262
122ROCK20.49717830
123PRKD10.48402324
124FYN0.46438402
125MARK30.44793899
126CDK140.44198564
127HIPK20.43960350
128ITK0.43383137
129MAPK110.42904229
130EPHB20.42879366
131PBK0.42806804
132MAP3K20.42155408
133CHUK0.42037645
134CAMKK20.41404704
135RPS6KA50.41166316
136NME10.40944211
137PLK20.40613339
138PINK10.38938020
139TXK0.38268400
140RPS6KA10.38120185
141MARK20.36165944
142RET0.35829458
143PKN20.34287416
144FLT30.31236062

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.85496113
2Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.14869329
3Malaria_Homo sapiens_hsa051442.05542903
4Other glycan degradation_Homo sapiens_hsa005112.00597465
5Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.86138628
6SNARE interactions in vesicular transport_Homo sapiens_hsa041301.74117177
7Osteoclast differentiation_Homo sapiens_hsa043801.73105097
8Leishmaniasis_Homo sapiens_hsa051401.69237440
9Dorso-ventral axis formation_Homo sapiens_hsa043201.63940928
10Collecting duct acid secretion_Homo sapiens_hsa049661.60464379
11Renal cell carcinoma_Homo sapiens_hsa052111.48882705
12Viral myocarditis_Homo sapiens_hsa054161.46911393
13Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.42888877
14Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.41813117
15VEGF signaling pathway_Homo sapiens_hsa043701.39305834
16TNF signaling pathway_Homo sapiens_hsa046681.34971871
17AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.33367073
18Toxoplasmosis_Homo sapiens_hsa051451.33183303
19Steroid biosynthesis_Homo sapiens_hsa001001.31506233
20Toll-like receptor signaling pathway_Homo sapiens_hsa046201.30718905
21Pertussis_Homo sapiens_hsa051331.30689009
22Legionellosis_Homo sapiens_hsa051341.30546041
23Leukocyte transendothelial migration_Homo sapiens_hsa046701.28968195
24Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.25066594
25Jak-STAT signaling pathway_Homo sapiens_hsa046301.23183268
26Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.20387627
27Chronic myeloid leukemia_Homo sapiens_hsa052201.19274072
28B cell receptor signaling pathway_Homo sapiens_hsa046621.18412465
29Focal adhesion_Homo sapiens_hsa045101.18204346
30Galactose metabolism_Homo sapiens_hsa000521.17641998
31Hematopoietic cell lineage_Homo sapiens_hsa046401.15648122
32Shigellosis_Homo sapiens_hsa051311.15487477
33ECM-receptor interaction_Homo sapiens_hsa045121.14206845
34Pancreatic cancer_Homo sapiens_hsa052121.12495828
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.11219169
36NF-kappa B signaling pathway_Homo sapiens_hsa040641.09419898
37Lysosome_Homo sapiens_hsa041421.08945239
38Prion diseases_Homo sapiens_hsa050201.08554629
39Ether lipid metabolism_Homo sapiens_hsa005651.08143656
40African trypanosomiasis_Homo sapiens_hsa051431.07685762
41Glycosaminoglycan degradation_Homo sapiens_hsa005311.07519433
42Chemokine signaling pathway_Homo sapiens_hsa040621.06942415
43Proteoglycans in cancer_Homo sapiens_hsa052051.06907312
44Notch signaling pathway_Homo sapiens_hsa043301.06298182
45Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.05760729
46Measles_Homo sapiens_hsa051621.04342270
47Vibrio cholerae infection_Homo sapiens_hsa051101.04168244
48Salmonella infection_Homo sapiens_hsa051321.03754917
49Endocytosis_Homo sapiens_hsa041441.03633363
50Tuberculosis_Homo sapiens_hsa051521.01964564
51HIF-1 signaling pathway_Homo sapiens_hsa040661.01478789
52Apoptosis_Homo sapiens_hsa042101.01091194
53Fatty acid biosynthesis_Homo sapiens_hsa000611.00968055
54Synaptic vesicle cycle_Homo sapiens_hsa047210.99874733
55Adipocytokine signaling pathway_Homo sapiens_hsa049200.99856636
56Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.99417774
57Amoebiasis_Homo sapiens_hsa051460.98522597
58Small cell lung cancer_Homo sapiens_hsa052220.97769018
59Mineral absorption_Homo sapiens_hsa049780.96928261
60Rheumatoid arthritis_Homo sapiens_hsa053230.96855146
61Regulation of actin cytoskeleton_Homo sapiens_hsa048100.95561268
62Sphingolipid signaling pathway_Homo sapiens_hsa040710.94795326
63Nitrogen metabolism_Homo sapiens_hsa009100.94541609
64Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.92774984
65Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.92396114
66Complement and coagulation cascades_Homo sapiens_hsa046100.92095069
67Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.91742952
68Phospholipase D signaling pathway_Homo sapiens_hsa040720.91204759
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.90776568
70Platelet activation_Homo sapiens_hsa046110.89914236
71Graft-versus-host disease_Homo sapiens_hsa053320.89740046
72T cell receptor signaling pathway_Homo sapiens_hsa046600.89559381
73Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.88993923
74Arachidonic acid metabolism_Homo sapiens_hsa005900.88725810
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86653423
76MicroRNAs in cancer_Homo sapiens_hsa052060.86299010
77NOD-like receptor signaling pathway_Homo sapiens_hsa046210.84822823
78Gap junction_Homo sapiens_hsa045400.84417953
79Bladder cancer_Homo sapiens_hsa052190.84099584
80Pancreatic secretion_Homo sapiens_hsa049720.82876743
81Rap1 signaling pathway_Homo sapiens_hsa040150.82825431
82Protein digestion and absorption_Homo sapiens_hsa049740.82525694
83Adherens junction_Homo sapiens_hsa045200.82133462
84Choline metabolism in cancer_Homo sapiens_hsa052310.81622401
85Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.80620502
86Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.79490459
87Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.79190570
88Sphingolipid metabolism_Homo sapiens_hsa006000.78754570
89Acute myeloid leukemia_Homo sapiens_hsa052210.78256069
90Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.77388984
91Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.76565540
92Hepatitis B_Homo sapiens_hsa051610.75308479
93Long-term depression_Homo sapiens_hsa047300.74762602
94Glioma_Homo sapiens_hsa052140.74625615
95MAPK signaling pathway_Homo sapiens_hsa040100.73085374
96Dilated cardiomyopathy_Homo sapiens_hsa054140.73018867
97Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71302962
98Tight junction_Homo sapiens_hsa045300.71210168
99Allograft rejection_Homo sapiens_hsa053300.71163643
100Asthma_Homo sapiens_hsa053100.71099455
101Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.70634256
102Ras signaling pathway_Homo sapiens_hsa040140.70218217
103Hepatitis C_Homo sapiens_hsa051600.68148343
104Pentose phosphate pathway_Homo sapiens_hsa000300.67602254
105Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.67595692
106Sulfur metabolism_Homo sapiens_hsa009200.67275069
107Circadian rhythm_Homo sapiens_hsa047100.66395576
108Neurotrophin signaling pathway_Homo sapiens_hsa047220.66029454
109Staphylococcus aureus infection_Homo sapiens_hsa051500.65544146
110Influenza A_Homo sapiens_hsa051640.64597046
111Axon guidance_Homo sapiens_hsa043600.64381149
112Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.63352537
113PI3K-Akt signaling pathway_Homo sapiens_hsa041510.63193375
114RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.62150869
115GnRH signaling pathway_Homo sapiens_hsa049120.61894918
116Transcriptional misregulation in cancer_Homo sapiens_hsa052020.61674284
117PPAR signaling pathway_Homo sapiens_hsa033200.59557052
118Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.59444750
119Phagosome_Homo sapiens_hsa041450.59071078
120Gastric acid secretion_Homo sapiens_hsa049710.58841339
121Glutathione metabolism_Homo sapiens_hsa004800.58689282
122Oxytocin signaling pathway_Homo sapiens_hsa049210.58629898
123Insulin resistance_Homo sapiens_hsa049310.58606793
124Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57213528
125Fructose and mannose metabolism_Homo sapiens_hsa000510.46948533
126Vascular smooth muscle contraction_Homo sapiens_hsa042700.44848644
127Non-small cell lung cancer_Homo sapiens_hsa052230.44722411
128Glycerolipid metabolism_Homo sapiens_hsa005610.43842582

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