SMPD4P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sphingosine metabolic process (GO:0006670)6.13814935
2protein neddylation (GO:0045116)5.79028355
3diol metabolic process (GO:0034311)5.73794265
4sphingoid metabolic process (GO:0046519)5.42239340
5DNA methylation involved in gamete generation (GO:0043046)5.36141906
6thrombin receptor signaling pathway (GO:0070493)4.95773571
7centriole replication (GO:0007099)4.78544243
8regulation of meiosis I (GO:0060631)4.72361182
9meiotic chromosome segregation (GO:0045132)4.61004182
10regulation of protein glycosylation (GO:0060049)4.32884194
11neutrophil activation involved in immune response (GO:0002283)4.05902445
12microtubule depolymerization (GO:0007019)4.00545855
13piRNA metabolic process (GO:0034587)3.99173569
14purinergic nucleotide receptor signaling pathway (GO:0035590)3.69704675
15DNA deamination (GO:0045006)3.67799071
16protein-chromophore linkage (GO:0018298)3.65798354
17amine catabolic process (GO:0009310)3.64378532
18cellular biogenic amine catabolic process (GO:0042402)3.64378532
19DNA double-strand break processing (GO:0000729)3.63085463
20L-phenylalanine catabolic process (GO:0006559)3.63076217
21erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.63076217
22negative regulation of heart rate (GO:0010459)3.53422453
23sulfate transmembrane transport (GO:1902358)3.52656000
24regulation of platelet activation (GO:0010543)3.52032925
25regulation of platelet aggregation (GO:0090330)3.51875063
26positive regulation of mast cell activation (GO:0033005)3.51597833
27tyrosine metabolic process (GO:0006570)3.50998447
28positive regulation of developmental pigmentation (GO:0048087)3.49002461
29tachykinin receptor signaling pathway (GO:0007217)3.42557937
30indolalkylamine metabolic process (GO:0006586)3.42336067
31regulation of rhodopsin mediated signaling pathway (GO:0022400)3.37849859
32regulation of pigment cell differentiation (GO:0050932)3.30677872
33positive regulation of endothelial cell differentiation (GO:0045603)3.30214332
34centriole assembly (GO:0098534)3.28335963
35sulfate transport (GO:0008272)3.27328106
36aromatic amino acid family catabolic process (GO:0009074)3.23316541
37negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.20789848
38regulation of nuclear cell cycle DNA replication (GO:0033262)3.20340193
39blood coagulation, intrinsic pathway (GO:0007597)3.19517844
40rhodopsin mediated signaling pathway (GO:0016056)3.19192863
41positive regulation of cAMP-mediated signaling (GO:0043950)3.15163316
42lipopolysaccharide biosynthetic process (GO:0009103)3.13656919
43regulation of memory T cell differentiation (GO:0043380)3.10105243
44male meiosis (GO:0007140)3.09136003
45regulation of lipoprotein metabolic process (GO:0050746)3.08530956
46autophagic vacuole fusion (GO:0000046)3.06245117
47negative regulation of thymocyte apoptotic process (GO:0070244)3.05288782
48negative regulation of stress fiber assembly (GO:0051497)3.03552252
49negative regulation of norepinephrine secretion (GO:0010700)3.01657315
50negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.00194850
51positive regulation of T cell cytokine production (GO:0002726)2.97862777
52negative regulation of response to food (GO:0032096)2.91565722
53negative regulation of appetite (GO:0032099)2.91565722
54fatty acid elongation (GO:0030497)2.91098947
55sulfation (GO:0051923)2.88887417
56triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.88403528
57indole-containing compound catabolic process (GO:0042436)2.87974607
58indolalkylamine catabolic process (GO:0046218)2.87974607
59tryptophan catabolic process (GO:0006569)2.87974607
60negative regulation of platelet activation (GO:0010544)2.85847832
61glycerophospholipid catabolic process (GO:0046475)2.83299794
62platelet aggregation (GO:0070527)2.83125408
63lipopolysaccharide metabolic process (GO:0008653)2.82882772
64negative regulation of glycoprotein biosynthetic process (GO:0010561)2.82320869
65tryptophan metabolic process (GO:0006568)2.82095513
66regulation of Golgi to plasma membrane protein transport (GO:0042996)2.79483312
67phosphatidylinositol acyl-chain remodeling (GO:0036149)2.79198094
68mast cell activation involved in immune response (GO:0002279)2.78131253
69mast cell degranulation (GO:0043303)2.78131253
70reciprocal DNA recombination (GO:0035825)2.77256201
71reciprocal meiotic recombination (GO:0007131)2.77256201
72erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.76879796
73L-phenylalanine metabolic process (GO:0006558)2.76879796
74platelet dense granule organization (GO:0060155)2.76082688
75fusion of sperm to egg plasma membrane (GO:0007342)2.74661318
76negative regulation of calcium ion transport into cytosol (GO:0010523)2.74368285
77aromatic amino acid family metabolic process (GO:0009072)2.73767386
78low-density lipoprotein particle remodeling (GO:0034374)2.72152974
79negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.72073588
80double-strand break repair via homologous recombination (GO:0000724)2.71932436
81recombinational repair (GO:0000725)2.71437061
82organelle membrane fusion (GO:0090174)2.71101490
83detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.69064181
84adenosine metabolic process (GO:0046085)2.68955842
85serotonin receptor signaling pathway (GO:0007210)2.68345867
86G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.68135593
87positive regulation of protein homodimerization activity (GO:0090073)2.66721869
88termination of G-protein coupled receptor signaling pathway (GO:0038032)2.64701310
89regulation of integrin-mediated signaling pathway (GO:2001044)2.61502578
90negative regulation of neural precursor cell proliferation (GO:2000178)2.61272712
91negative regulation of protein localization to cell surface (GO:2000009)2.60772904
92positive regulation of uterine smooth muscle contraction (GO:0070474)2.59999322
93leukocyte migration involved in inflammatory response (GO:0002523)2.58942143
94negative regulation of cell cycle G2/M phase transition (GO:1902750)2.58911739
95adaptation of signaling pathway (GO:0023058)2.57474518
96regulation of MHC class II biosynthetic process (GO:0045346)2.57469238
97gamma-aminobutyric acid signaling pathway (GO:0007214)2.56912422
98microtubule polymerization or depolymerization (GO:0031109)2.56829663
99regulation of triglyceride catabolic process (GO:0010896)2.56611479
100methionine biosynthetic process (GO:0009086)2.55814238

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.67257766
2VDR_22108803_ChIP-Seq_LS180_Human3.40151958
3IGF1R_20145208_ChIP-Seq_DFB_Human3.10618309
4GBX2_23144817_ChIP-Seq_PC3_Human2.87393278
5LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.50301569
6POU3F2_20337985_ChIP-ChIP_501MEL_Human2.47738312
7SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.33578112
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.31096302
9ER_23166858_ChIP-Seq_MCF-7_Human2.17041368
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.15935962
11ZNF274_21170338_ChIP-Seq_K562_Hela2.09608369
12SCL_19346495_ChIP-Seq_HPC-7_Human2.04453183
13TAF15_26573619_Chip-Seq_HEK293_Human1.93621563
14EWS_26573619_Chip-Seq_HEK293_Human1.91391737
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.91028406
16P300_19829295_ChIP-Seq_ESCs_Human1.88742566
17CTBP2_25329375_ChIP-Seq_LNCAP_Human1.77145971
18EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.75782277
19EZH2_22144423_ChIP-Seq_EOC_Human1.72097442
20AR_21572438_ChIP-Seq_LNCaP_Human1.71995766
21ZFP57_27257070_Chip-Seq_ESCs_Mouse1.71142481
22AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.70693991
23SOX2_19829295_ChIP-Seq_ESCs_Human1.60097031
24NANOG_19829295_ChIP-Seq_ESCs_Human1.60097031
25GATA3_21878914_ChIP-Seq_MCF-7_Human1.57502507
26STAT3_23295773_ChIP-Seq_U87_Human1.55623113
27TCF4_23295773_ChIP-Seq_U87_Human1.53105654
28UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.53040420
29FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.51469649
30GATA1_19941826_ChIP-Seq_K562_Human1.50963300
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.50321659
32EZH2_27294783_Chip-Seq_NPCs_Mouse1.49842701
33SUZ12_27294783_Chip-Seq_NPCs_Mouse1.49782232
34EGR1_23403033_ChIP-Seq_LIVER_Mouse1.48520043
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.48435072
36GATA2_19941826_ChIP-Seq_K562_Human1.46586720
37NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.43766998
38CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.43418859
39GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.41478778
40FOXA1_25329375_ChIP-Seq_VCAP_Human1.41307761
41FOXA1_27270436_Chip-Seq_PROSTATE_Human1.41307761
42SMAD4_21799915_ChIP-Seq_A2780_Human1.41132143
43FUS_26573619_Chip-Seq_HEK293_Human1.38576139
44SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.37612208
45BCAT_22108803_ChIP-Seq_LS180_Human1.36767714
46NFE2_27457419_Chip-Seq_LIVER_Mouse1.36094755
47HTT_18923047_ChIP-ChIP_STHdh_Human1.34117969
48TP53_22573176_ChIP-Seq_HFKS_Human1.33977644
49AR_25329375_ChIP-Seq_VCAP_Human1.33638825
50HOXB7_26014856_ChIP-Seq_BT474_Human1.33259975
51CTBP1_25329375_ChIP-Seq_LNCAP_Human1.30628287
52LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.28807678
53IRF1_19129219_ChIP-ChIP_H3396_Human1.26300692
54KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.25804783
55FOXA1_21572438_ChIP-Seq_LNCaP_Human1.24752633
56TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23858492
57SALL4_22934838_ChIP-ChIP_CD34+_Human1.23840268
58CRX_20693478_ChIP-Seq_RETINA_Mouse1.22523931
59E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.21076798
60SALL1_21062744_ChIP-ChIP_HESCs_Human1.20769991
61RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.20166542
62GATA2_21666600_ChIP-Seq_HMVEC_Human1.20119867
63P53_22387025_ChIP-Seq_ESCs_Mouse1.18321550
64MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.18021441
65CDX2_22108803_ChIP-Seq_LS180_Human1.17731904
66OCT4_21477851_ChIP-Seq_ESCs_Mouse1.17526438
67CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.15657738
68TCF4_22108803_ChIP-Seq_LS180_Human1.15464501
69FLI1_21867929_ChIP-Seq_TH2_Mouse1.14639785
70PRDM14_20953172_ChIP-Seq_ESCs_Human1.14043968
71GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.13476388
72TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.11891985
73E2F7_22180533_ChIP-Seq_HELA_Human1.11525039
74STAT3_18555785_Chip-Seq_ESCs_Mouse1.11425999
75AR_20517297_ChIP-Seq_VCAP_Human1.11230762
76GATA1_22025678_ChIP-Seq_K562_Human1.10993642
77PHF8_20622853_ChIP-Seq_HELA_Human1.10457075
78E2F1_18555785_Chip-Seq_ESCs_Mouse1.09160260
79SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08293889
80CBP_20019798_ChIP-Seq_JUKART_Human1.07373890
81IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.07373890
82SMAD4_21741376_ChIP-Seq_EPCs_Human1.06701339
83HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.06258785
84STAT1_20625510_ChIP-Seq_HELA_Human1.05662162
85ELK1_19687146_ChIP-ChIP_HELA_Human1.05628483
86TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05534165
87SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.05387221
88TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04959982
89POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04959982
90CEBPB_22108803_ChIP-Seq_LS180_Human1.02449410
91PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.02207094
92ETV1_20927104_ChIP-Seq_GIST48_Human1.02188605
93GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.01366359
94PIAS1_25552417_ChIP-Seq_VCAP_Human1.01195073
95MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.01159505
96NANOG_18555785_Chip-Seq_ESCs_Mouse1.00723086
97EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99595174
98RBPJ_21746931_ChIP-Seq_IB4_Human0.99379785
99NFYA_21822215_ChIP-Seq_K562_Human0.99277907
100NCOR_22424771_ChIP-Seq_293T_Human0.98808660

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology5.29582080
2MP0002837_dystrophic_cardiac_calcinosis4.51715783
3MP0003136_yellow_coat_color4.46490562
4MP0005171_absent_coat_pigmentation3.96082565
5MP0004147_increased_porphyrin_level3.62141898
6MP0002653_abnormal_ependyma_morphology3.36799103
7MP0008004_abnormal_stomach_pH2.49549146
8MP0003045_fibrosis2.38361528
9MP0000569_abnormal_digit_pigmentation2.27291501
10MP0005410_abnormal_fertilization2.20527522
11MP0002736_abnormal_nociception_after2.15255469
12MP0003890_abnormal_embryonic-extraembry2.14162393
13MP0003646_muscle_fatigue2.08456654
14MP0005670_abnormal_white_adipose2.04051194
15MP0008872_abnormal_physiological_respon1.99165834
16MP0005646_abnormal_pituitary_gland1.92251611
17MP0002102_abnormal_ear_morphology1.87180120
18MP0008877_abnormal_DNA_methylation1.81514767
19MP0005085_abnormal_gallbladder_physiolo1.78059643
20MP0005083_abnormal_biliary_tract1.74356818
21MP0003724_increased_susceptibility_to1.72352431
22MP0003195_calcinosis1.67297483
23MP0003879_abnormal_hair_cell1.65979791
24MP0003718_maternal_effect1.65186167
25MP0001968_abnormal_touch/_nociception1.62814349
26MP0005075_abnormal_melanosome_morpholog1.60782538
27MP0000372_irregular_coat_pigmentation1.57065417
28MP0000465_gastrointestinal_hemorrhage1.56154134
29MP0005084_abnormal_gallbladder_morpholo1.51349366
30MP0008057_abnormal_DNA_replication1.48568280
31MP0005551_abnormal_eye_electrophysiolog1.45522629
32MP0008775_abnormal_heart_ventricle1.44597394
33MP0000230_abnormal_systemic_arterial1.43081461
34MP0005365_abnormal_bile_salt1.39727848
35MP0006276_abnormal_autonomic_nervous1.37486124
36MP0002138_abnormal_hepatobiliary_system1.31840929
37MP0003656_abnormal_erythrocyte_physiolo1.31276172
38MP0002938_white_spotting1.29733417
39MP0002095_abnormal_skin_pigmentation1.29214806
40MP0008875_abnormal_xenobiotic_pharmacok1.28471887
41MP0004381_abnormal_hair_follicle1.26242438
42MP0008058_abnormal_DNA_repair1.26197987
43MP0006054_spinal_hemorrhage1.26002695
44MP0004084_abnormal_cardiac_muscle1.25670799
45MP0005174_abnormal_tail_pigmentation1.22269539
46MP0004142_abnormal_muscle_tone1.14343583
47MP0003252_abnormal_bile_duct1.13098362
48MP0005167_abnormal_blood-brain_barrier1.12669991
49MP0009046_muscle_twitch1.11504539
50MP0004043_abnormal_pH_regulation1.09929521
51MP0000015_abnormal_ear_pigmentation1.09744904
52MP0010329_abnormal_lipoprotein_level1.08978083
53MP0002733_abnormal_thermal_nociception1.07322750
54MP0006036_abnormal_mitochondrial_physio1.07288210
55MP0002735_abnormal_chemical_nociception1.05239402
56MP0001501_abnormal_sleep_pattern1.03442093
57MP0002132_abnormal_respiratory_system1.01938115
58MP0001984_abnormal_olfaction1.00686958
59MP0004215_abnormal_myocardial_fiber1.00201811
60MP0005395_other_phenotype0.99854099
61MP0001929_abnormal_gametogenesis0.97954936
62MP0002876_abnormal_thyroid_physiology0.97538068
63MP0010094_abnormal_chromosome_stability0.96501749
64MP0003698_abnormal_male_reproductive0.95071962
65MP0001835_abnormal_antigen_presentation0.94632850
66MP0001970_abnormal_pain_threshold0.93520877
67MP0009764_decreased_sensitivity_to0.92767766
68MP0003137_abnormal_impulse_conducting0.92426242
69MP0005253_abnormal_eye_physiology0.92214231
70MP0002210_abnormal_sex_determination0.85962600
71MP0006035_abnormal_mitochondrial_morpho0.84787457
72MP0003638_abnormal_response/metabolism_0.82459793
73MP0002148_abnormal_hypersensitivity_rea0.82357735
74MP0002272_abnormal_nervous_system0.80628478
75MP0002398_abnormal_bone_marrow0.79873435
76MP0005397_hematopoietic_system_phenotyp0.79116817
77MP0001545_abnormal_hematopoietic_system0.79116817
78MP0005389_reproductive_system_phenotype0.78242015
79MP0001661_extended_life_span0.78071930
80MP0009697_abnormal_copulation0.78058743
81MP0000383_abnormal_hair_follicle0.77840517
82MP0000427_abnormal_hair_cycle0.77694264
83MP0002160_abnormal_reproductive_system0.76616770
84MP0006292_abnormal_olfactory_placode0.76542636
85MP0000689_abnormal_spleen_morphology0.75742198
86MP0000653_abnormal_sex_gland0.73434166
87MP0002168_other_aberrant_phenotype0.71817938
88MP0004130_abnormal_muscle_cell0.71472049
89MP0009765_abnormal_xenobiotic_induced0.71035764
90MP0009763_increased_sensitivity_to0.70705448
91MP0004036_abnormal_muscle_relaxation0.68534389
92MP0004085_abnormal_heartbeat0.67559398
93MP0008995_early_reproductive_senescence0.66708781
94MP0001145_abnormal_male_reproductive0.65723925
95MP0005535_abnormal_body_temperature0.64795112
96MP0001764_abnormal_homeostasis0.64763798
97MP0005671_abnormal_response_to0.62343092
98MP0001800_abnormal_humoral_immune0.61789328
99MP0003186_abnormal_redox_activity0.60841973
100MP0002118_abnormal_lipid_homeostasis0.60641974

Predicted human phenotypes

RankGene SetZ-score
1Prolonged bleeding time (HP:0003010)6.42661679
2Petechiae (HP:0000967)6.21797144
3Menorrhagia (HP:0000132)5.36790834
4Increased mean platelet volume (HP:0011877)5.20920604
5Acanthocytosis (HP:0001927)5.07448169
6Purpura (HP:0000979)4.83767375
7Abnormal platelet volume (HP:0011876)4.79212652
8Poikilocytosis (HP:0004447)4.42041991
9Epistaxis (HP:0000421)4.28470971
10Amelogenesis imperfecta (HP:0000705)3.53588224
11Spontaneous hematomas (HP:0007420)3.53336874
12Pancreatic cysts (HP:0001737)3.40769358
13Gingival bleeding (HP:0000225)3.33265324
14Hyperlipoproteinemia (HP:0010980)3.13031774
15Focal motor seizures (HP:0011153)3.07890841
16Impaired platelet aggregation (HP:0003540)3.03079420
17Abnormal platelet function (HP:0011869)3.03079420
18Aplasia/Hypoplasia of the uvula (HP:0010293)3.02801424
19Abnormality of the heme biosynthetic pathway (HP:0010472)3.01632547
20Type II lissencephaly (HP:0007260)2.99835018
21Abnormality of the renal cortex (HP:0011035)2.91337971
22Pancreatic fibrosis (HP:0100732)2.78066203
233-Methylglutaconic aciduria (HP:0003535)2.77030156
24Conjunctival telangiectasia (HP:0000524)2.73403370
25Dyschromatopsia (HP:0007641)2.72429241
26Hyperthyroidism (HP:0000836)2.68163553
27Aplastic anemia (HP:0001915)2.67357259
28Decreased central vision (HP:0007663)2.54008658
29Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.53422421
30Abnormality of DNA repair (HP:0003254)2.47575773
31Congenital stationary night blindness (HP:0007642)2.41880989
32Hypoplastic iliac wings (HP:0002866)2.40984818
33Attenuation of retinal blood vessels (HP:0007843)2.39900624
34Chromosomal breakage induced by crosslinking agents (HP:0003221)2.38977177
35Abnormality of the renal medulla (HP:0100957)2.34166877
36Abnormal pupillary function (HP:0007686)2.27413531
37Tinnitus (HP:0000360)2.22665304
38Abnormality of the vasculature of the conjunctiva (HP:0008054)2.20820491
39Pendular nystagmus (HP:0012043)2.19674450
40Chromsome breakage (HP:0040012)2.18928997
41Ileus (HP:0002595)2.17000822
42Nephronophthisis (HP:0000090)2.15869652
43Parakeratosis (HP:0001036)2.14527660
44Ectopic kidney (HP:0000086)2.10681738
45True hermaphroditism (HP:0010459)2.10298941
46Duplicated collecting system (HP:0000081)2.09391136
47Abnormality of lateral ventricle (HP:0030047)2.08923825
48Pancytopenia (HP:0001876)2.00713222
49Renal cortical cysts (HP:0000803)2.00680175
50Autoimmune hemolytic anemia (HP:0001890)2.00578706
51Lissencephaly (HP:0001339)1.97701014
52Albinism (HP:0001022)1.97295189
53Abnormality of the renal collecting system (HP:0004742)1.96897984
54Dialeptic seizures (HP:0011146)1.96445103
55Abnormality of alanine metabolism (HP:0010916)1.96340347
56Hyperalaninemia (HP:0003348)1.96340347
57Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.96340347
58Abnormal auditory evoked potentials (HP:0006958)1.94859253
59Abolished electroretinogram (ERG) (HP:0000550)1.93731341
60Thyroid-stimulating hormone excess (HP:0002925)1.92770777
61Pancreatic islet-cell hyperplasia (HP:0004510)1.91358814
62Bruising susceptibility (HP:0000978)1.89429514
63Birth length less than 3rd percentile (HP:0003561)1.85361598
64Truncus arteriosus (HP:0001660)1.84776995
65Abnormality of chromosome stability (HP:0003220)1.84104820
66Upper limb muscle weakness (HP:0003484)1.82522266
67Gaze-evoked nystagmus (HP:0000640)1.81083108
68Cerebellar dysplasia (HP:0007033)1.79622087
69Colon cancer (HP:0003003)1.77697536
70Abnormality of midbrain morphology (HP:0002418)1.76735538
71Molar tooth sign on MRI (HP:0002419)1.76735538
72Stomatitis (HP:0010280)1.75986273
73Enlarged kidneys (HP:0000105)1.71905718
74Generalized aminoaciduria (HP:0002909)1.69113466
75Meckel diverticulum (HP:0002245)1.68114545
76Paralysis (HP:0003470)1.67748032
77Central scotoma (HP:0000603)1.67475709
78Cystic liver disease (HP:0006706)1.67058269
79Hematochezia (HP:0002573)1.66838236
80Polydipsia (HP:0001959)1.64153798
81Abnormal drinking behavior (HP:0030082)1.64153798
82Abnormality of the ileum (HP:0001549)1.63973454
83Biliary tract neoplasm (HP:0100574)1.62821642
84Hyperventilation (HP:0002883)1.61976718
85Difficulty walking (HP:0002355)1.59509961
86Febrile seizures (HP:0002373)1.59079250
87Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.58775410
88Clubbing of toes (HP:0100760)1.58661866
89Neoplasm of the small intestine (HP:0100833)1.57685832
90Portal hypertension (HP:0001409)1.57378124
91Abnormal ciliary motility (HP:0012262)1.57004026
92Hypomagnesemia (HP:0002917)1.56767324
93Hypoplasia of the pons (HP:0012110)1.56215965
94IgG deficiency (HP:0004315)1.56203453
95Methylmalonic aciduria (HP:0012120)1.55391184
96Aplasia/Hypoplasia of the earlobes (HP:0009906)1.55100342
97Pachygyria (HP:0001302)1.54487592
98Dynein arm defect of respiratory motile cilia (HP:0012255)1.54139882
99Absent/shortened dynein arms (HP:0200106)1.54139882
100Abnormality of homocysteine metabolism (HP:0010919)1.52472748

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.45629315
2FRK4.17952761
3STK38L3.82184970
4MST43.44719999
5BMPR1B2.96283889
6TAOK32.80333055
7RIPK42.50457556
8ZAK2.47321088
9ACVR1B2.46827664
10STK32.42040807
11EIF2AK12.38522960
12PIK3CG2.34455066
13TEC2.28543322
14ADRBK22.23254990
15BMX1.76545902
16TXK1.74148228
17NUAK11.71595341
18TNIK1.66446089
19LATS21.66166149
20NLK1.62844972
21PTK2B1.58213765
22MAP4K21.53714096
23MAPK131.49012849
24BTK1.43517128
25MYLK1.35145300
26TRIM281.33032438
27GRK51.27082953
28BMPR21.18449705
29PLK21.16747873
30WNK31.13006385
31MAP3K21.11047181
32MAP2K21.09154161
33DAPK21.08826609
34BRSK21.07008840
35STK381.04600191
36ADRBK11.02156398
37GRK11.00403717
38MAPKAPK30.99707759
39SYK0.98854257
40MAP3K40.96039878
41TAF10.90940615
42TNK20.86147973
43TGFBR10.85585126
44NTRK30.81769626
45WNK40.80518731
46FER0.76984909
47OXSR10.75259011
48INSRR0.75199268
49IKBKB0.74712062
50ERBB30.68896077
51LMTK20.68782731
52NEK20.66228232
53ITK0.66136433
54GRK60.65861550
55PINK10.62572999
56CSF1R0.62378416
57STK390.62135148
58MAP2K10.60251436
59PLK40.58458728
60PLK30.58067614
61MELK0.57754630
62DYRK20.54716514
63CDK80.53170705
64TTK0.52540614
65HCK0.50770041
66TLK10.49341489
67ZAP700.47555094
68EIF2AK30.47167434
69PRKD10.46362422
70PRKAA20.45293374
71ATR0.44951649
72PNCK0.44607473
73MATK0.43437329
74LYN0.42986472
75CSNK1A1L0.40681449
76CDK30.39971669
77PDPK10.36778283
78PKN10.36365276
79PAK10.36322788
80PRKCE0.35900459
81PDK20.35732308
82CSNK1D0.35266271
83TRPM70.34562521
84PLK10.33700311
85CAMKK20.32580288
86PIM10.31249194
87VRK10.31051434
88PRKACG0.30807513
89MAP2K60.30200048
90CCNB10.29778503
91PAK30.29759618
92IRAK10.29299144
93PRKG10.28239827
94ABL10.27791245
95FES0.27402095
96PRKACA0.26358684
97ATM0.25771531
98MAPKAPK50.25411834
99CAMK2A0.24204084
100IGF1R0.24090611

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047443.59275198
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.29519158
3Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006013.09970848
4Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.05476139
5Platelet activation_Homo sapiens_hsa046112.88299355
6Nitrogen metabolism_Homo sapiens_hsa009102.71715204
7Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.42400223
8Fanconi anemia pathway_Homo sapiens_hsa034602.37157565
9Olfactory transduction_Homo sapiens_hsa047402.35021702
10One carbon pool by folate_Homo sapiens_hsa006702.24724617
11Linoleic acid metabolism_Homo sapiens_hsa005912.21876657
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.21435829
13Homologous recombination_Homo sapiens_hsa034402.20371410
14Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.89357385
15Basal transcription factors_Homo sapiens_hsa030221.85962041
16Tryptophan metabolism_Homo sapiens_hsa003801.81153655
17Butanoate metabolism_Homo sapiens_hsa006501.79753796
18Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.72029737
19Arachidonic acid metabolism_Homo sapiens_hsa005901.69843771
20Morphine addiction_Homo sapiens_hsa050321.65812845
21Collecting duct acid secretion_Homo sapiens_hsa049661.64286739
22SNARE interactions in vesicular transport_Homo sapiens_hsa041301.63961413
23ABC transporters_Homo sapiens_hsa020101.61683235
24Sphingolipid metabolism_Homo sapiens_hsa006001.60671222
25Mismatch repair_Homo sapiens_hsa034301.58558474
26Nicotine addiction_Homo sapiens_hsa050331.57853034
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.57696961
28Hematopoietic cell lineage_Homo sapiens_hsa046401.53672287
29Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.45895388
30Glycerolipid metabolism_Homo sapiens_hsa005611.43804968
31Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.42421566
32Serotonergic synapse_Homo sapiens_hsa047261.36378856
33Taste transduction_Homo sapiens_hsa047421.32831841
34Steroid biosynthesis_Homo sapiens_hsa001001.24273211
35Steroid hormone biosynthesis_Homo sapiens_hsa001401.17512312
36GABAergic synapse_Homo sapiens_hsa047271.16778829
37Ether lipid metabolism_Homo sapiens_hsa005651.15882212
38Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.14737045
39Fatty acid elongation_Homo sapiens_hsa000621.14273047
40Maturity onset diabetes of the young_Homo sapiens_hsa049501.11395141
41Chemical carcinogenesis_Homo sapiens_hsa052040.93318260
42Dorso-ventral axis formation_Homo sapiens_hsa043200.92922960
43ECM-receptor interaction_Homo sapiens_hsa045120.90018346
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.89520481
45Glutathione metabolism_Homo sapiens_hsa004800.89264502
46Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.88060644
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.87921949
48Vascular smooth muscle contraction_Homo sapiens_hsa042700.86541297
49beta-Alanine metabolism_Homo sapiens_hsa004100.85205618
50Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.84578379
51Cysteine and methionine metabolism_Homo sapiens_hsa002700.84242883
52Retinol metabolism_Homo sapiens_hsa008300.83780297
53Propanoate metabolism_Homo sapiens_hsa006400.82926415
54Calcium signaling pathway_Homo sapiens_hsa040200.82063943
55Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.80494027
56RNA polymerase_Homo sapiens_hsa030200.80107181
57Circadian entrainment_Homo sapiens_hsa047130.80065662
58Caffeine metabolism_Homo sapiens_hsa002320.79378474
59Nucleotide excision repair_Homo sapiens_hsa034200.78632252
60Purine metabolism_Homo sapiens_hsa002300.78604200
61Oxidative phosphorylation_Homo sapiens_hsa001900.77280612
62Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.74764748
63Fat digestion and absorption_Homo sapiens_hsa049750.66722248
64Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.65912563
65Primary bile acid biosynthesis_Homo sapiens_hsa001200.65807716
66Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.62550149
67Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.61304446
68N-Glycan biosynthesis_Homo sapiens_hsa005100.60667977
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58694982
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58527896
71Glycerophospholipid metabolism_Homo sapiens_hsa005640.58157772
72Asthma_Homo sapiens_hsa053100.56163709
73Non-homologous end-joining_Homo sapiens_hsa034500.52535003
74Glutamatergic synapse_Homo sapiens_hsa047240.52452570
75Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51448640
76Selenocompound metabolism_Homo sapiens_hsa004500.51413097
77Parkinsons disease_Homo sapiens_hsa050120.50186083
78Intestinal immune network for IgA production_Homo sapiens_hsa046720.48115835
79Metabolic pathways_Homo sapiens_hsa011000.47685043
80Peroxisome_Homo sapiens_hsa041460.46968112
81Pyrimidine metabolism_Homo sapiens_hsa002400.44959013
82Pancreatic secretion_Homo sapiens_hsa049720.44303087
83Ovarian steroidogenesis_Homo sapiens_hsa049130.42914962
84Chemokine signaling pathway_Homo sapiens_hsa040620.39497602
85Gap junction_Homo sapiens_hsa045400.38245659
86Tyrosine metabolism_Homo sapiens_hsa003500.38115696
87Long-term depression_Homo sapiens_hsa047300.35684638
88Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.34986362
89Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.33510258
90Primary immunodeficiency_Homo sapiens_hsa053400.32939190
91Rheumatoid arthritis_Homo sapiens_hsa053230.30006838
92Salivary secretion_Homo sapiens_hsa049700.29994680
93Starch and sucrose metabolism_Homo sapiens_hsa005000.28550487
94Cell cycle_Homo sapiens_hsa041100.27642146
95Arginine and proline metabolism_Homo sapiens_hsa003300.27040541
96Alcoholism_Homo sapiens_hsa050340.25446736
97Regulation of autophagy_Homo sapiens_hsa041400.23615232
98Graft-versus-host disease_Homo sapiens_hsa053320.23106343
99RNA degradation_Homo sapiens_hsa030180.23022666
100Oocyte meiosis_Homo sapiens_hsa041140.22960362

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