SMPDL3A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1angiotensin maturation (GO:0002003)5.51076725
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.24425495
3epoxygenase P450 pathway (GO:0019373)5.15938924
4fat-soluble vitamin biosynthetic process (GO:0042362)4.52916503
5regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.30859771
6intestinal absorption (GO:0050892)4.22713020
7cellular glucuronidation (GO:0052695)4.11458647
8uronic acid metabolic process (GO:0006063)4.07036465
9glucuronate metabolic process (GO:0019585)4.07036465
10antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.85696006
11antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.85696006
12very-low-density lipoprotein particle assembly (GO:0034379)3.81831050
13urate metabolic process (GO:0046415)3.81450842
14exogenous drug catabolic process (GO:0042738)3.75063488
15phospholipid efflux (GO:0033700)3.74129729
16aminoglycoside antibiotic metabolic process (GO:0030647)3.69315130
17hormone catabolic process (GO:0042447)3.66410405
18regulation of cholesterol esterification (GO:0010872)3.60554438
19valine metabolic process (GO:0006573)3.60227645
20bile acid and bile salt transport (GO:0015721)3.59793747
21regulation of interferon-beta biosynthetic process (GO:0045357)3.57273893
22drug metabolic process (GO:0017144)3.56720728
23fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.49433232
24antigen processing and presentation of endogenous antigen (GO:0019883)3.47382749
25neutrophil activation involved in immune response (GO:0002283)3.45514210
26cholesterol efflux (GO:0033344)3.43890826
27adhesion of symbiont to host cell (GO:0044650)3.36670739
28virion attachment to host cell (GO:0019062)3.36670739
29modulation by symbiont of host immune response (GO:0052553)3.35314524
30positive regulation by symbiont of host defense response (GO:0052509)3.35314524
31modulation by symbiont of host defense response (GO:0052031)3.35314524
32modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.35314524
33modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.35314524
34positive regulation by organism of defense response of other organism involved in symbiotic interact3.35314524
35lipoprotein transport (GO:0042953)3.34658010
36heme transport (GO:0015886)3.33464834
37drug transmembrane transport (GO:0006855)3.32476008
38regulation of fibrinolysis (GO:0051917)3.32025961
39bile acid metabolic process (GO:0008206)3.31244596
40urea metabolic process (GO:0019627)3.30699345
41glycosphingolipid catabolic process (GO:0046479)3.29190104
42plasma lipoprotein particle assembly (GO:0034377)3.29138956
43drug transport (GO:0015893)3.27889758
44peptide hormone processing (GO:0016486)3.26104698
45omega-hydroxylase P450 pathway (GO:0097267)3.23521102
46glycolipid catabolic process (GO:0019377)3.22548621
47NADH metabolic process (GO:0006734)3.20938443
48vitamin biosynthetic process (GO:0009110)3.18821545
49regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.18644340
50regulation of triglyceride catabolic process (GO:0010896)3.18339355
51phenylpropanoid metabolic process (GO:0009698)3.17880387
52high-density lipoprotein particle remodeling (GO:0034375)3.16929594
53urea cycle (GO:0000050)3.13144141
54protein-lipid complex assembly (GO:0065005)3.12628208
55regulation of guanylate cyclase activity (GO:0031282)3.11793582
56production of molecular mediator involved in inflammatory response (GO:0002532)3.07435084
57transcytosis (GO:0045056)3.07394292
58toxin transport (GO:1901998)3.06781716
59cysteine metabolic process (GO:0006534)3.06099710
60protein-lipid complex remodeling (GO:0034368)3.05300914
61macromolecular complex remodeling (GO:0034367)3.05300914
62plasma lipoprotein particle remodeling (GO:0034369)3.05300914
63regulation of bile acid biosynthetic process (GO:0070857)3.04329892
64reverse cholesterol transport (GO:0043691)3.03598188
65regulation of cholesterol homeostasis (GO:2000188)3.02278328
66macroautophagy (GO:0016236)3.01467362
67nitrogen cycle metabolic process (GO:0071941)2.99478216
68flavonoid metabolic process (GO:0009812)2.99033507
69lysine metabolic process (GO:0006553)2.98088209
70lysine catabolic process (GO:0006554)2.98088209
71lipoprotein metabolic process (GO:0042157)2.94173380
72L-phenylalanine metabolic process (GO:0006558)2.92324561
73erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.92324561
74adhesion of symbiont to host (GO:0044406)2.92320495
75erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.89482226
76L-phenylalanine catabolic process (GO:0006559)2.89482226
77respiratory burst (GO:0045730)2.88832751
78positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.87300699
79regulation of protein activation cascade (GO:2000257)2.86789125
80alkaloid metabolic process (GO:0009820)2.85701980
81ceramide catabolic process (GO:0046514)2.85219919
82positive regulation of interferon-alpha production (GO:0032727)2.83942134
83regulation of vitamin metabolic process (GO:0030656)2.82454276
84vitamin D metabolic process (GO:0042359)2.82154120
85glycoside metabolic process (GO:0016137)2.81732290
86peptide catabolic process (GO:0043171)2.79775510
87protein carboxylation (GO:0018214)2.79324226
88peptidyl-glutamic acid carboxylation (GO:0017187)2.79324226
89response to thyroid hormone (GO:0097066)2.79043158
90regulation of complement activation (GO:0030449)2.78979662
91intestinal cholesterol absorption (GO:0030299)2.77000155
92branched-chain amino acid metabolic process (GO:0009081)2.76996546
93positive regulation of lipoprotein lipase activity (GO:0051006)2.76974788
94positive regulation of triglyceride lipase activity (GO:0061365)2.76974788
95regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.76813101
96endocrine process (GO:0050886)2.76813101
97regulation of systemic arterial blood pressure by hormone (GO:0001990)2.76813101
98tricarboxylic acid metabolic process (GO:0072350)2.76149301
99positive regulation of antigen processing and presentation (GO:0002579)2.75853267
100plasma lipoprotein particle organization (GO:0071827)2.75834724
101negative regulation of cholesterol transport (GO:0032375)2.75389749
102negative regulation of sterol transport (GO:0032372)2.75389749
103low-density lipoprotein particle remodeling (GO:0034374)2.74509880
104ethanol metabolic process (GO:0006067)2.73978614
105negative regulation of protein activation cascade (GO:2000258)2.73534391
106fibrinolysis (GO:0042730)2.72851328
107sulfur amino acid catabolic process (GO:0000098)2.72467144
108protein-lipid complex subunit organization (GO:0071825)2.70059421
109glyoxylate metabolic process (GO:0046487)2.69863422
110regulation of interferon-alpha production (GO:0032647)2.69646492
111positive regulation of lipid catabolic process (GO:0050996)2.67939711
112pinocytosis (GO:0006907)2.67766315
113regulation of extracellular matrix disassembly (GO:0010715)2.66760635
114immunoglobulin mediated immune response (GO:0016064)2.66698158
115bile acid biosynthetic process (GO:0006699)2.65175913
116positive regulation of gamma-delta T cell activation (GO:0046645)2.65144173
117amino-acid betaine metabolic process (GO:0006577)2.64250558
118regulation of B cell receptor signaling pathway (GO:0050855)2.63513493
119arginine metabolic process (GO:0006525)2.63316723
120organic cation transport (GO:0015695)2.62700441
121triglyceride homeostasis (GO:0070328)2.62366398
122acylglycerol homeostasis (GO:0055090)2.62366398
123complement activation, alternative pathway (GO:0006957)2.62296023
124negative regulation of hemostasis (GO:1900047)2.61294567
125negative regulation of blood coagulation (GO:0030195)2.61294567
126negative regulation of complement activation (GO:0045916)2.60929611
127carnitine metabolic process (GO:0009437)2.60535020
128L-ascorbic acid metabolic process (GO:0019852)2.59153049
129fatty acid beta-oxidation (GO:0006635)2.58530603
130* sphingolipid catabolic process (GO:0030149)2.57695682
131hydrogen peroxide biosynthetic process (GO:0050665)2.57139794
132* membrane lipid catabolic process (GO:0046466)2.56660145
133negative regulation of fibrinolysis (GO:0051918)2.56287111
134macrophage activation involved in immune response (GO:0002281)2.55862751
135maintenance of gastrointestinal epithelium (GO:0030277)2.55288283
136negative regulation of coagulation (GO:0050819)2.54390413
137lipid oxidation (GO:0034440)2.51541491
138leukotriene metabolic process (GO:0006691)2.51223878
139response to peptidoglycan (GO:0032494)2.50356092
140Arp2/3 complex-mediated actin nucleation (GO:0034314)2.50328193
141cellular extravasation (GO:0045123)2.50293731
142positive regulation of cellular amide metabolic process (GO:0034250)2.49993512
143homocysteine metabolic process (GO:0050667)2.49244976
144fatty acid oxidation (GO:0019395)2.46983358
145branched-chain amino acid catabolic process (GO:0009083)2.46400057
146quaternary ammonium group transport (GO:0015697)2.43427753
147reactive oxygen species biosynthetic process (GO:1903409)2.42222973
148lipoxygenase pathway (GO:0019372)2.42031328
149regulation of cholesterol storage (GO:0010885)2.40813758
150apoptotic cell clearance (GO:0043277)2.39833406
151T cell migration (GO:0072678)2.38051072
152response to host immune response (GO:0052572)2.36376594
153response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.36376594
154antigen processing and presentation via MHC class Ib (GO:0002475)2.36166575
155superoxide anion generation (GO:0042554)2.35568576
156fatty acid catabolic process (GO:0009062)2.35474340
157alpha-linolenic acid metabolic process (GO:0036109)2.35140915
158modified amino acid transport (GO:0072337)2.34720148
159regulation of apoptotic cell clearance (GO:2000425)2.33832959
160cellular modified amino acid catabolic process (GO:0042219)2.33575202
161regulation of antigen processing and presentation (GO:0002577)2.31658622
162response to type I interferon (GO:0034340)2.31285561
163short-chain fatty acid metabolic process (GO:0046459)2.29746428
164leukotriene biosynthetic process (GO:0019370)2.28728289
165neutrophil activation (GO:0042119)2.27667456
166type I interferon signaling pathway (GO:0060337)2.27286144
167cellular response to type I interferon (GO:0071357)2.27286144
168detection of molecule of bacterial origin (GO:0032490)2.26810511
169triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.26258994
170positive regulation of macrophage differentiation (GO:0045651)2.24757321
171response to interferon-beta (GO:0035456)2.24652375
172leukocyte aggregation (GO:0070486)2.24508932
173drug catabolic process (GO:0042737)2.24345220
174renal absorption (GO:0070293)2.23403996
175granulocyte activation (GO:0036230)2.23352569
176fructose metabolic process (GO:0006000)2.20980665
177myeloid cell activation involved in immune response (GO:0002275)2.20499391
178response to interferon-alpha (GO:0035455)2.20031695
179detection of other organism (GO:0098543)2.19501755
180positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.19234799
181mitochondrial calcium ion transport (GO:0006851)2.18640644
1822-oxoglutarate metabolic process (GO:0006103)2.18293275
183mannose metabolic process (GO:0006013)2.17582564
184oligosaccharide catabolic process (GO:0009313)2.17363813
185ethanol oxidation (GO:0006069)2.17344697
186interferon-gamma-mediated signaling pathway (GO:0060333)2.17175055
187response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.16776702
188response to host (GO:0075136)2.16776702
189response to host defenses (GO:0052200)2.16776702
190leukocyte cell-cell adhesion (GO:0007159)2.16621496

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.69307215
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.20365276
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.91970183
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.51924458
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.44808361
6RXR_22158963_ChIP-Seq_LIVER_Mouse3.20520025
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.13968025
8PPARA_22158963_ChIP-Seq_LIVER_Mouse2.92608873
9IRF8_27001747_Chip-Seq_BMDM_Mouse2.91619356
10* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.88554773
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.72739190
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.67535382
13* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.66857913
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.65144208
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.56269614
16* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.54928980
17STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.52280975
18* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.51193587
19* CDX2_19796622_ChIP-Seq_MESCs_Mouse2.47140963
20LXR_22158963_ChIP-Seq_LIVER_Mouse2.43468596
21FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.29638742
22RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.19188543
23RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.18434105
24TRIM28_21343339_ChIP-Seq_HEK293_Human2.09952701
25SCL_19346495_ChIP-Seq_HPC-7_Human2.08571051
26RARG_19884340_ChIP-ChIP_MEFs_Mouse2.05485416
27EGR1_23403033_ChIP-Seq_LIVER_Mouse2.01043093
28FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.87304566
29STAT4_19710469_ChIP-ChIP_TH1__Mouse1.86884453
30RUNX_20019798_ChIP-Seq_JUKART_Human1.86160084
31* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.86040463
32* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.82143763
33TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.75969660
34STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.72434859
35TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64070736
36EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.62613374
37SPI1_23547873_ChIP-Seq_NB4_Human1.61508159
38TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.61197433
39SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.59520311
40FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.58843173
41LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.56129681
42TP63_17297297_ChIP-ChIP_HaCaT_Human1.54687870
43CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.52315496
44GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.51958931
45MYB_26560356_Chip-Seq_TH2_Human1.50763415
46* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.50596840
47GATA1_22025678_ChIP-Seq_K562_Human1.50382978
48ZNF217_24962896_ChIP-Seq_MCF-7_Human1.49697647
49LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.49216007
50RUNX1_22412390_ChIP-Seq_EML_Mouse1.47854840
51ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.46386139
52CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.46119925
53MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.45877621
54FOXA2_19822575_ChIP-Seq_HepG2_Human1.45706442
55MAF_26560356_Chip-Seq_TH1_Human1.43213768
56GATA2_21666600_ChIP-Seq_HMVEC_Human1.42056558
57VDR_24763502_ChIP-Seq_THP-1_Human1.41322106
58BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.40781076
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.39703662
60CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.39118300
61CJUN_26792858_Chip-Seq_BT549_Human1.38769038
62* CDX2_22108803_ChIP-Seq_LS180_Human1.36480751
63CLOCK_20551151_ChIP-Seq_293T_Human1.36302465
64FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.35973543
65* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.35293272
66ESR1_21235772_ChIP-Seq_MCF-7_Human1.35243092
67ESR2_21235772_ChIP-Seq_MCF-7_Human1.34835183
68CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.33491006
69E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.32820875
70PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.32580316
71PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.32251880
72GATA6_25053715_ChIP-Seq_YYC3_Human1.31421037
73NRF2_20460467_ChIP-Seq_MEFs_Mouse1.31121808
74NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.31121808
75VDR_24787735_ChIP-Seq_THP-1_Human1.30818976
76SALL4_18804426_ChIP-ChIP_XEN_Mouse1.29615737
77SMAD_19615063_ChIP-ChIP_OVARY_Human1.28074833
78* FOXA1_25552417_ChIP-Seq_VCAP_Human1.27744443
79SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.27257465
80FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.27096920
81SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.27031435
82* PU_27001747_Chip-Seq_BMDM_Mouse1.23904307
83* HNF4A_19822575_ChIP-Seq_HepG2_Human1.22189534
84SOX2_20726797_ChIP-Seq_SW620_Human1.21879207
85MYB_26560356_Chip-Seq_TH1_Human1.20901525
86NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.19356692
87PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18565013
88GATA4_25053715_ChIP-Seq_YYC3_Human1.18520108
89SPI1_23127762_ChIP-Seq_K562_Human1.18288187
90CDX2_20551321_ChIP-Seq_CACO-2_Human1.17211950
91AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16415505
92P63_26484246_Chip-Seq_KERATINOCYTES_Human1.15654080
93SOX2_27498859_Chip-Seq_STOMACH_Mouse1.15432982
94HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.15209369
95TP63_23658742_ChIP-Seq_EP156T_Human1.14628694
96CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.14608550
97CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14455705
98TP53_18474530_ChIP-ChIP_U2OS_Human1.14359885
99VDR_21846776_ChIP-Seq_THP-1_Human1.14163259
100GATA3_27048872_Chip-Seq_THYMUS_Human1.13837447
101GATA1_22383799_ChIP-Seq_G1ME_Mouse1.12049899
102TCF4_18268006_ChIP-ChIP_LS174T_Human1.11638496
103ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.10987396
104GATA1_19941827_ChIP-Seq_MEL_Mouse1.10887188
105CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.10427178
106SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10332051
107TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10276963
108GATA2_22383799_ChIP-Seq_G1ME_Mouse1.10251529
109* LXR_22292898_ChIP-Seq_THP-1_Human1.07398238
110PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07091977
111GATA2_19941826_ChIP-Seq_K562_Human1.06691708
112BCAT_22108803_ChIP-Seq_LS180_Human1.05524267
113GATA1_19941826_ChIP-Seq_K562_Human1.03931543
114CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03347485
115PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03305218
116POU3F2_20337985_ChIP-ChIP_501MEL_Human0.99764301
117EGR1_19032775_ChIP-ChIP_M12_Human0.98291715
118* ELK3_25401928_ChIP-Seq_HUVEC_Human0.96545847
119ESR1_20079471_ChIP-ChIP_T-47D_Human0.95227452
120UTX_26944678_Chip-Seq_JUKART_Human0.94742786
121SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93994367
122GATA3_26560356_Chip-Seq_TH2_Human0.93993295
123AHR_22903824_ChIP-Seq_MCF-7_Human0.92613623
124TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.91394875
125TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.90194864
126ZFP57_27257070_Chip-Seq_ESCs_Mouse0.89803045
127CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.89653692
128NR3C1_21868756_ChIP-Seq_MCF10A_Human0.89493210
129* GATA3_24758297_ChIP-Seq_MCF-7_Human0.89044912
130EP300_21415370_ChIP-Seq_HL-1_Mouse0.89004446
131HTT_18923047_ChIP-ChIP_STHdh_Human0.88217692
132PPAR_26484153_Chip-Seq_NCI-H1993_Human0.86952886
133FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.86832191
134NR3C1_23031785_ChIP-Seq_PC12_Mouse0.85928528
135GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.85696814
136FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.84209129
137NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.84082324
138* FOXO3_23340844_ChIP-Seq_DLD1_Human0.83950956
139STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.83710745
140BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.83706730
141RACK7_27058665_Chip-Seq_MCF-7_Human0.82956949
142FOXM1_26456572_ChIP-Seq_MCF-7_Human0.81667217
143CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.81626797
144TCF7_22412390_ChIP-Seq_EML_Mouse0.81524913
145PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.81484516
146CBP_21632823_ChIP-Seq_H3396_Human0.81405960
147* EZH2_27294783_Chip-Seq_NPCs_Mouse0.80952178
148SUZ12_27294783_Chip-Seq_NPCs_Mouse0.80902613
149PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.80743621
150TP53_16413492_ChIP-PET_HCT116_Human0.79461533
151CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.78484330
152EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.78419991
153PCGF2_27294783_Chip-Seq_ESCs_Mouse0.78066282
154SMAD3_21741376_ChIP-Seq_HESCs_Human0.77945840
155* TCF4_22108803_ChIP-Seq_LS180_Human0.77521132
156* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.77024724
157JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.76971366
158OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.76570858
159TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.74716162
160RXR_22108803_ChIP-Seq_LS180_Human0.73884654

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis3.23509971
2MP0005058_abnormal_lysosome_morphology3.16962569
3MP0010234_abnormal_vibrissa_follicle3.14955298
4MP0002138_abnormal_hepatobiliary_system2.88234662
5MP0001835_abnormal_antigen_presentation2.84827259
6MP0003724_increased_susceptibility_to2.75042450
7MP0009840_abnormal_foam_cell2.65236916
8MP0003436_decreased_susceptibility_to2.59085078
9MP0002139_abnormal_hepatobiliary_system2.43369242
10MP0000685_abnormal_immune_system2.34807178
11MP0009785_altered_susceptibility_to2.30532640
12MP0002419_abnormal_innate_immunity2.16839499
13MP0005332_abnormal_amino_acid2.15847940
14MP0003191_abnormal_cellular_cholesterol2.15517253
15MP0005365_abnormal_bile_salt2.13336950
16MP0002876_abnormal_thyroid_physiology2.11186331
17MP0003868_abnormal_feces_composition2.09797098
18MP0002148_abnormal_hypersensitivity_rea2.07184776
19MP0006082_CNS_inflammation2.05243034
20MP0005025_abnormal_response_to2.04847968
21MP0005387_immune_system_phenotype1.98701482
22MP0001790_abnormal_immune_system1.98701482
23MP0004019_abnormal_vitamin_homeostasis1.96985458
24MP0008875_abnormal_xenobiotic_pharmacok1.96198761
25MP0009643_abnormal_urine_homeostasis1.94040090
26MP0005000_abnormal_immune_tolerance1.91834412
27MP0005671_abnormal_response_to1.80698514
28MP0003300_gastrointestinal_ulcer1.79812424
29MP0003186_abnormal_redox_activity1.76706019
30MP0002254_reproductive_system_inflammat1.74990542
31MP0001853_heart_inflammation1.74857802
32MP0009780_abnormal_chondrocyte_physiolo1.71266209
33MP0005464_abnormal_platelet_physiology1.70814238
34MP0002452_abnormal_antigen_presenting1.67621488
35MP0009764_decreased_sensitivity_to1.65095771
36MP0001666_abnormal_nutrient_absorption1.63471069
37MP0005085_abnormal_gallbladder_physiolo1.62753621
38MP0000343_altered_response_to1.60861930
39MP0001845_abnormal_inflammatory_respons1.60483725
40MP0008469_abnormal_protein_level1.59577310
41MP0003075_altered_response_to1.59332623
42MP0002723_abnormal_immune_serum1.56058850
43MP0001533_abnormal_skeleton_physiology1.55737022
44MP0001800_abnormal_humoral_immune1.53455960
45MP0001873_stomach_inflammation1.52331841
46MP0003303_peritoneal_inflammation1.51521995
47MP0002136_abnormal_kidney_physiology1.50557858
48MP0001819_abnormal_immune_cell1.49894172
49MP0002420_abnormal_adaptive_immunity1.49323038
50MP0010155_abnormal_intestine_physiology1.46169553
51MP0004147_increased_porphyrin_level1.44844860
52MP0003172_abnormal_lysosome_physiology1.42129699
53MP0005083_abnormal_biliary_tract1.41733215
54MP0010329_abnormal_lipoprotein_level1.37829642
55MP0005319_abnormal_enzyme/_coenzyme1.36580183
56MP0002166_altered_tumor_susceptibility1.35637699
57MP0003879_abnormal_hair_cell1.35631893
58MP0004947_skin_inflammation1.35453278
59MP0004264_abnormal_extraembryonic_tissu1.35301012
60MP0003195_calcinosis1.35149944
61MP0002405_respiratory_system_inflammati1.32206847
62MP0010352_gastrointestinal_tract_polyps1.32038584
63MP0000604_amyloidosis1.27888084
64MP0004510_myositis1.27760159
65MP0002796_impaired_skin_barrier1.25691228
66MP0005636_abnormal_mineral_homeostasis1.25608302
67MP0005584_abnormal_enzyme/coenzyme_acti1.23902429
68MP0005167_abnormal_blood-brain_barrier1.23305793
69MP0001958_emphysema1.22358542
70MP0001756_abnormal_urination1.20992349
71MP0002909_abnormal_adrenal_gland1.19475044
72MP0003252_abnormal_bile_duct1.19203524
73MP0005166_decreased_susceptibility_to1.18243895
74MP0000465_gastrointestinal_hemorrhage1.17843004
75MP0002998_abnormal_bone_remodeling1.17180202
76MP0004043_abnormal_pH_regulation1.17081614
77MP0001765_abnormal_ion_homeostasis1.15821156
78MP0000609_abnormal_liver_physiology1.14982315
79MP0004782_abnormal_surfactant_physiolog1.13035020
80MP0002971_abnormal_brown_adipose1.12683326
81MP0005275_abnormal_skin_tensile1.11778487
82MP0003329_amyloid_beta_deposits1.11734041
83MP0003690_abnormal_glial_cell1.09986530
84MP0000716_abnormal_immune_system1.07140139
85MP0002118_abnormal_lipid_homeostasis1.05942222
86MP0008438_abnormal_cutaneous_collagen1.02855357
87MP0005377_hearing/vestibular/ear_phenot1.01406216
88MP0003878_abnormal_ear_physiology1.01406216
89MP0001664_abnormal_digestion1.01174491
90MP0010678_abnormal_skin_adnexa1.01160789
91MP0010386_abnormal_urinary_bladder1.00047542
92MP0003763_abnormal_thymus_physiology0.99505237
93MP0000689_abnormal_spleen_morphology0.99013238
94MP0003806_abnormal_nucleotide_metabolis0.98386648
95MP0005310_abnormal_salivary_gland0.97595935
96MP0005165_increased_susceptibility_to0.96667115
97MP0000538_abnormal_urinary_bladder0.96222892
98MP0003183_abnormal_peptide_metabolism0.96215968
99MP0002006_tumorigenesis0.95521892
100MP0005535_abnormal_body_temperature0.94427312
101MP0003638_abnormal_response/metabolism_0.94388550
102MP0009333_abnormal_splenocyte_physiolog0.93900069
103MP0005448_abnormal_energy_balance0.93864833
104MP0004130_abnormal_muscle_cell0.93714310
105MP0003866_abnormal_defecation0.93427123
106MP0001663_abnormal_digestive_system0.93259905
107MP0001764_abnormal_homeostasis0.92330497
108MP0003656_abnormal_erythrocyte_physiolo0.91986915
109MP0005257_abnormal_intraocular_pressure0.90648793
110MP0005409_darkened_coat_color0.90437547
111MP0006054_spinal_hemorrhage0.90348221
112MP0002933_joint_inflammation0.89176252
113MP0002722_abnormal_immune_system0.88993846
114MP0002398_abnormal_bone_marrow0.88521327
115MP0002078_abnormal_glucose_homeostasis0.88361902
116MP0009763_increased_sensitivity_to0.88074995
117MP0002896_abnormal_bone_mineralization0.87339692
118MP0005670_abnormal_white_adipose0.86504018
119MP0002429_abnormal_blood_cell0.85893439
120MP0002132_abnormal_respiratory_system0.85735014
121MP0001501_abnormal_sleep_pattern0.85593797
122MP0003828_pulmonary_edema0.84065612
123MP0005451_abnormal_body_composition0.83855688
124MP0000858_altered_metastatic_potential0.80721755
125MP0005084_abnormal_gallbladder_morpholo0.80496705
126MP0005164_abnormal_response_to0.77744419
127MP0008004_abnormal_stomach_pH0.77523287
128MP0009642_abnormal_blood_homeostasis0.73936769
129MP0000230_abnormal_systemic_arterial0.71180443
130MP0002098_abnormal_vibrissa_morphology0.67745714
131MP0005376_homeostasis/metabolism_phenot0.66708539
132MP0002693_abnormal_pancreas_physiology0.63673294
133MP0003453_abnormal_keratinocyte_physiol0.62718874
134MP0000462_abnormal_digestive_system0.61940225
135MP0005381_digestive/alimentary_phenotyp0.60158963
136MP0001542_abnormal_bone_strength0.59478593
137MP0004270_analgesia0.59138024
138MP0009115_abnormal_fat_cell0.57653631
139MP0003953_abnormal_hormone_level0.57154973
140MP0004272_abnormal_basement_membrane0.56838137
141MP0000013_abnormal_adipose_tissue0.56489312
142MP0000477_abnormal_intestine_morphology0.56465676
143MP0005408_hypopigmentation0.56301104
144MP0002837_dystrophic_cardiac_calcinosis0.56078370
145MP0009379_abnormal_foot_pigmentation0.54887251

Predicted human phenotypes

RankGene SetZ-score
1Vacuolated lymphocytes (HP:0001922)4.91965731
2Hypobetalipoproteinemia (HP:0003563)4.84863012
3Malnutrition (HP:0004395)4.61491178
4Abnormality of monocarboxylic acid metabolism (HP:0010996)4.53704547
5Eczematoid dermatitis (HP:0000976)4.26346748
6Fat malabsorption (HP:0002630)4.09043399
7Recurrent abscess formation (HP:0002722)4.08709552
8Abnormality of macrophages (HP:0004311)3.90588991
9Systemic lupus erythematosus (HP:0002725)3.80589198
10Dysostosis multiplex (HP:0000943)3.76917475
11Recurrent gram-negative bacterial infections (HP:0005420)3.73586602
12Recurrent bacterial skin infections (HP:0005406)3.69679891
13Conjugated hyperbilirubinemia (HP:0002908)3.56033685
14Urinary glycosaminoglycan excretion (HP:0003541)3.41363298
15Mucopolysacchariduria (HP:0008155)3.41363298
16Prolonged partial thromboplastin time (HP:0003645)3.32974511
17Steatorrhea (HP:0002570)3.25587841
18Abnormality of complement system (HP:0005339)3.22095106
19Intrahepatic cholestasis (HP:0001406)3.18351159
20Hyperactive renin-angiotensin system (HP:0000841)3.16155346
21Generalized aminoaciduria (HP:0002909)3.15605667
22Hypolipoproteinemia (HP:0010981)3.15379769
23Gout (HP:0001997)3.12754951
24Abnormality of polysaccharide metabolism (HP:0011012)3.12326066
25Abnormality of glycosaminoglycan metabolism (HP:0004371)3.12326066
26Abnormality of mucopolysaccharide metabolism (HP:0011020)3.12326066
27Abnormality of vitamin metabolism (HP:0100508)3.11653203
28Myositis (HP:0100614)3.10883517
29Increased cerebral lipofuscin (HP:0011813)3.09898219
30Hyperglycinuria (HP:0003108)3.06444272
31Hypokalemic alkalosis (HP:0001949)3.02589510
32Abnormality of glutamine family amino acid metabolism (HP:0010902)2.95261091
33Deep venous thrombosis (HP:0002625)2.90086806
34Abnormality of vitamin B metabolism (HP:0004340)2.87127684
35Abnormality of purine metabolism (HP:0004352)2.83404946
36Increased neuronal autofluorescent lipopigment (HP:0002074)2.78414144
37Elevated erythrocyte sedimentation rate (HP:0003565)2.78388507
38Axonal loss (HP:0003447)2.77679012
39Metabolic alkalosis (HP:0200114)2.76511011
40Widely patent fontanelles and sutures (HP:0004492)2.76393411
41Abnormality of fatty-acid metabolism (HP:0004359)2.69662180
42Pustule (HP:0200039)2.68498116
43Proximal tubulopathy (HP:0000114)2.66508110
44Orchitis (HP:0100796)2.64370668
45Abnormality of chloride homeostasis (HP:0011422)2.64170489
46Autoimmune thrombocytopenia (HP:0001973)2.60363596
47Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.51989646
48Skin nodule (HP:0200036)2.51346515
49Xanthomatosis (HP:0000991)2.50898622
50IgM deficiency (HP:0002850)2.49309535
51Interstitial pulmonary disease (HP:0006530)2.49127240
52Congenital sensorineural hearing impairment (HP:0008527)2.48952743
53Abnormality of glycine metabolism (HP:0010895)2.48619676
54Abnormality of serine family amino acid metabolism (HP:0010894)2.48619676
55Epidermoid cyst (HP:0200040)2.47955943
56Hydroxyprolinuria (HP:0003080)2.47246219
57Abnormality of proline metabolism (HP:0010907)2.47246219
58Recurrent skin infections (HP:0001581)2.45080867
59Spontaneous hematomas (HP:0007420)2.43139547
60Abnormality of the vitamin B12 metabolism (HP:0004341)2.43097926
61Abnormality of renal excretion (HP:0011036)2.40525772
62Increased circulating renin level (HP:0000848)2.39099404
63Glomerulonephritis (HP:0000099)2.38378978
64Hyperglycemia (HP:0003074)2.38247468
65Hypoglycemic coma (HP:0001325)2.35134464
66Increased CSF protein (HP:0002922)2.34380085
67Gingivitis (HP:0000230)2.33437768
68Abnormality of the nasal mucosa (HP:0000433)2.33412459
69Abnormal urine output (HP:0012590)2.33317764
70Esophageal varix (HP:0002040)2.31743046
71Polyuria (HP:0000103)2.30935684
72Abnormality of liposaccharide metabolism (HP:0010968)2.29433833
73Abnormality of glycosphingolipid metabolism (HP:0004343)2.29433833
74Abnormality of glycolipid metabolism (HP:0010969)2.29433833
75Loss of speech (HP:0002371)2.26467927
76Ketoacidosis (HP:0001993)2.26262817
77Hyperlipoproteinemia (HP:0010980)2.26093189
78Hyperammonemia (HP:0001987)2.26082939
79Chronic diarrhea (HP:0002028)2.26006527
80Petechiae (HP:0000967)2.25528478
81Hypomagnesemia (HP:0002917)2.24457406
82Decreased circulating renin level (HP:0003351)2.23843666
83Protuberant abdomen (HP:0001538)2.23292002
84Abdominal distention (HP:0003270)2.23006107
85Hyperuricemia (HP:0002149)2.22425843
86Increased purine levels (HP:0004368)2.22425843
87Mitral stenosis (HP:0001718)2.21335347
88Ketosis (HP:0001946)2.21047107
89Hypothermia (HP:0002045)2.20540693
90Recurrent fungal infections (HP:0002841)2.19830142
91Amyloidosis (HP:0011034)2.19131271
92Urticaria (HP:0001025)2.18915945
93Abnormality of nucleobase metabolism (HP:0010932)2.18423042
94Alkalosis (HP:0001948)2.18308563
95Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.17517614
96Joint hemorrhage (HP:0005261)2.16779159
97Symptomatic seizures (HP:0011145)2.15798941
98Vascular calcification (HP:0004934)2.14111771
99Renal tubular acidosis (HP:0001947)2.13199275
100Chronic obstructive pulmonary disease (HP:0006510)2.11781003
101Obstructive lung disease (HP:0006536)2.11781003
102Asymmetric septal hypertrophy (HP:0001670)2.10967770
103Mediastinal lymphadenopathy (HP:0100721)2.10920125
104Hematochezia (HP:0002573)2.10004504
105Nausea (HP:0002018)2.09786356
106Abnormality of magnesium homeostasis (HP:0004921)2.09633853
107Right ventricular cardiomyopathy (HP:0011663)2.08175124
108Optic neuritis (HP:0100653)2.07680985
109Retrobulbar optic neuritis (HP:0100654)2.07680985
110Tetany (HP:0001281)2.06880527
111Rickets (HP:0002748)2.06179641
112Nasal polyposis (HP:0100582)2.03483978
113Abnormality of dicarboxylic acid metabolism (HP:0010995)2.03261026
114Dicarboxylic aciduria (HP:0003215)2.03261026
115Hypophosphatemia (HP:0002148)2.01989798
116Myocardial infarction (HP:0001658)2.01968584
117Complement deficiency (HP:0004431)1.99677503
118Thoracic kyphosis (HP:0002942)1.99236087
119Beaking of vertebral bodies (HP:0004568)1.98056449
120Glycosuria (HP:0003076)1.97826463
121Abnormality of urine glucose concentration (HP:0011016)1.97826463
122Abnormality of aromatic amino acid family metabolism (HP:0004338)1.96840529
123Late onset (HP:0003584)1.95584997
124Abnormality of the lumbar spine (HP:0100712)1.95408938
125Hyperphosphaturia (HP:0003109)1.94116516
126Hyperaldosteronism (HP:0000859)1.93583500
127Irritability (HP:0000737)1.92580020
128Metaphyseal irregularity (HP:0003025)1.91941849
129Nephritis (HP:0000123)1.90506357
130Pancreatitis (HP:0001733)1.89210944
131Abnormality of the common coagulation pathway (HP:0010990)1.88673462
132Abnormality of renin-angiotensin system (HP:0000847)1.88503991
133Anorexia (HP:0002039)1.88165105
134Hypoglycemic seizures (HP:0002173)1.87960717
135Exocrine pancreatic insufficiency (HP:0001738)1.87791230
136Renal salt wasting (HP:0000127)1.87714958
137Arterial thrombosis (HP:0004420)1.86367679
138Cardiovascular calcification (HP:0011915)1.85689626
139Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.85255318
140Tetraparesis (HP:0002273)1.85040805
141Hypoalphalipoproteinemia (HP:0003233)1.84003596
142Acanthocytosis (HP:0001927)1.83806750
143Progressive neurologic deterioration (HP:0002344)1.83435250
144Epistaxis (HP:0000421)1.82831009
145Hypokalemia (HP:0002900)1.81071511
146Hypotension (HP:0002615)1.79866745
147Thin bony cortex (HP:0002753)1.79023899
148Hyperparathyroidism (HP:0000843)1.75661625
149Hypercholesterolemia (HP:0003124)1.74688692
150Prolonged neonatal jaundice (HP:0006579)1.74032437
151Nephrolithiasis (HP:0000787)1.73974495
152Metabolic acidosis (HP:0001942)1.73157096
153Osteomalacia (HP:0002749)1.72607064
154Abnormal urine phosphate concentration (HP:0012599)1.72383374

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B4.92654796
2ERN13.23627833
3FRK3.10590205
4BCKDK3.10036624
5MAP4K12.82968200
6TGFBR22.46644321
7TBK12.41014389
8STK392.38974089
9IRAK32.31782709
10TYK22.26967770
11MAP3K142.24871059
12MAP3K32.23998864
13MST1R2.23031793
14BLK2.22700519
15IRAK42.18174137
16ZAP702.08916374
17KIT2.06592853
18DDR22.06476918
19TXK2.03365853
20MAP2K32.02236402
21IKBKE1.96024320
22KDR1.93615378
23TRIB31.92311019
24NME21.92060091
25MST41.72302095
26AKT31.65975817
27TIE11.65938918
28JAK31.65910663
29PHKG11.64470671
30PHKG21.64470671
31EPHB11.63994382
32WNK41.63298276
33BTK1.62058973
34EPHA21.59275128
35FGFR41.55811426
36GRK11.55566101
37LRRK21.54491248
38ADRBK21.51075378
39FER1.49499976
40STK101.48068090
41ERBB31.45147650
42TEC1.44700900
43PIM21.44404526
44RIPK41.40502211
45IKBKB1.35940022
46JAK11.34758145
47RIPK11.30773193
48GRK61.29934936
49TAOK31.25075319
50WNK31.19495201
51OBSCN1.13919755
52STK38L1.12402193
53MAP4K21.10361419
54CSK1.08400282
55CSF1R1.05237965
56STK241.04819400
57TESK11.01649308
58SYK1.01206072
59NLK0.99376465
60DAPK20.97774347
61OXSR10.97383532
62TRPM70.94828012
63NEK90.94447400
64JAK20.93996568
65TAOK10.93631900
66ABL20.92995123
67MYLK0.92931866
68LMTK20.92232260
69SIK10.91809272
70MAP3K130.91108561
71HCK0.90729222
72MATK0.89091551
73ITK0.88239098
74FGFR20.87219941
75LCK0.84975263
76LYN0.84959961
77CAMK2D0.84869356
78MAP3K110.83551236
79PKN20.78348871
80PRKG20.78243810
81CDC42BPA0.77624983
82PDPK10.75729998
83PDK20.74986334
84PIK3CG0.73301786
85PRKCE0.72532620
86PTK60.70912065
87FGFR30.69786966
88TNIK0.69654437
89MAP3K120.69379740
90LIMK10.69200897
91EPHA30.68960138
92BMPR20.68924605
93IRAK10.68398927
94MAP2K20.67523666
95MARK30.66438082
96DYRK1B0.66273402
97TRIM280.65598508
98PIM10.63737456
99RPS6KA40.63566723
100EPHB20.61747228
101STK30.61697802
102FES0.61287331
103MUSK0.60926694
104MAPKAPK30.59603049
105TGFBR10.59079631
106PINK10.57337988
107EIF2AK30.56307848
108PRKACG0.56051658
109CAMK1D0.55508480
110TTN0.55126881
111CHUK0.54973283
112MAPK70.54761177
113MAP2K60.53850726
114MAPK110.53423693
115YES10.53140131
116ARAF0.52547886
117NTRK30.52360895
118CAMKK20.52155464
119PAK30.51755441
120MAPK120.51334495
121CAMK2G0.51165563
122PRKCD0.50039023
123MAP3K50.49877788
124MAP3K60.49338755
125PDGFRA0.48949212
126GSK3A0.47161899
127MET0.47056216
128CASK0.45880964
129MAPK40.45801006
130MAP3K10.45262378
131PDK30.45239722
132PDK40.45239722
133ABL10.45112689
134IGF1R0.45103361
135GRK70.44995329
136MAP3K20.44613298
137PDK10.44509861
138PRKCA0.43373590
139MAP3K70.43333965
140PAK40.43300231
141PRKAA20.42443862
142PRKCZ0.41879067
143PTK20.40855013
144PRKAA10.39080325
145BMPR1B0.37640963
146SGK30.37113406
147ADRBK10.36910460
148PIK3CA0.36240822
149PRKCQ0.35195435
150EGFR0.35070948
151STK380.34356644
152FGR0.33768743
153PRKG10.32674029
154MAP2K40.31006982
155MAP3K40.30402619

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005112.85108815
2Pentose and glucuronate interconversions_Homo sapiens_hsa000402.82188880
3Staphylococcus aureus infection_Homo sapiens_hsa051502.69284437
4Caffeine metabolism_Homo sapiens_hsa002322.56260370
5Glycosaminoglycan degradation_Homo sapiens_hsa005312.43379753
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.42456216
7Maturity onset diabetes of the young_Homo sapiens_hsa049502.34173953
8Fatty acid degradation_Homo sapiens_hsa000712.28195513
9Lysosome_Homo sapiens_hsa041422.16268234
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.02744482
11Steroid hormone biosynthesis_Homo sapiens_hsa001401.89900537
12Peroxisome_Homo sapiens_hsa041461.89682470
13Leishmaniasis_Homo sapiens_hsa051401.83503196
14Propanoate metabolism_Homo sapiens_hsa006401.73687201
15Linoleic acid metabolism_Homo sapiens_hsa005911.58786363
16Starch and sucrose metabolism_Homo sapiens_hsa005001.56190244
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.54168451
18Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.53469649
19Fatty acid metabolism_Homo sapiens_hsa012121.51094393
20Complement and coagulation cascades_Homo sapiens_hsa046101.49667929
21Vitamin digestion and absorption_Homo sapiens_hsa049771.49264519
22PPAR signaling pathway_Homo sapiens_hsa033201.47260044
23Primary bile acid biosynthesis_Homo sapiens_hsa001201.45087577
24Folate biosynthesis_Homo sapiens_hsa007901.38214603
25beta-Alanine metabolism_Homo sapiens_hsa004101.37522162
26Pentose phosphate pathway_Homo sapiens_hsa000301.35655656
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.34054523
28Histidine metabolism_Homo sapiens_hsa003401.33247417
29Nitrogen metabolism_Homo sapiens_hsa009101.32683644
30Tryptophan metabolism_Homo sapiens_hsa003801.31577127
31alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.27486981
32Sulfur metabolism_Homo sapiens_hsa009201.27411851
33Intestinal immune network for IgA production_Homo sapiens_hsa046721.24480674
34Pertussis_Homo sapiens_hsa051331.20871334
35Phenylalanine metabolism_Homo sapiens_hsa003601.20658331
36Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.18949451
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.15764415
38Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.13936999
39Osteoclast differentiation_Homo sapiens_hsa043801.13845678
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.13555128
41Tuberculosis_Homo sapiens_hsa051521.13524197
42Legionellosis_Homo sapiens_hsa051341.10966357
43Arginine biosynthesis_Homo sapiens_hsa002201.10246732
44Toll-like receptor signaling pathway_Homo sapiens_hsa046201.10095552
45Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.09486216
46Malaria_Homo sapiens_hsa051441.09453207
47Butanoate metabolism_Homo sapiens_hsa006501.09400114
48Galactose metabolism_Homo sapiens_hsa000521.05655287
49Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.05331377
50Mineral absorption_Homo sapiens_hsa049781.05324029
51Glycerolipid metabolism_Homo sapiens_hsa005611.05016697
52Sulfur relay system_Homo sapiens_hsa041221.04870964
53NF-kappa B signaling pathway_Homo sapiens_hsa040640.98865833
54Chemical carcinogenesis_Homo sapiens_hsa052040.98373598
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.98268058
56Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.98171335
57Glutathione metabolism_Homo sapiens_hsa004800.98118065
58Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.96430575
59Ether lipid metabolism_Homo sapiens_hsa005650.95767287
60Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.94947306
61Rheumatoid arthritis_Homo sapiens_hsa053230.94172216
62Vitamin B6 metabolism_Homo sapiens_hsa007500.93806038
63Bile secretion_Homo sapiens_hsa049760.93004993
64Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.92633452
65Tyrosine metabolism_Homo sapiens_hsa003500.91514695
66Drug metabolism - other enzymes_Homo sapiens_hsa009830.90432829
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.89948374
68Carbon metabolism_Homo sapiens_hsa012000.89103712
69Pyruvate metabolism_Homo sapiens_hsa006200.87571201
70RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.87182600
71Renin-angiotensin system_Homo sapiens_hsa046140.84191026
72Measles_Homo sapiens_hsa051620.83932901
73Leukocyte transendothelial migration_Homo sapiens_hsa046700.82618305
74Antigen processing and presentation_Homo sapiens_hsa046120.81597933
75Primary immunodeficiency_Homo sapiens_hsa053400.79345475
76Carbohydrate digestion and absorption_Homo sapiens_hsa049730.78909409
77Phagosome_Homo sapiens_hsa041450.78088264
78Arginine and proline metabolism_Homo sapiens_hsa003300.77113347
79ABC transporters_Homo sapiens_hsa020100.76655257
80Toxoplasmosis_Homo sapiens_hsa051450.74450507
81Fat digestion and absorption_Homo sapiens_hsa049750.74217587
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.74154779
83Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.74095226
84Hematopoietic cell lineage_Homo sapiens_hsa046400.73979870
85Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.72894175
86Sphingolipid metabolism_Homo sapiens_hsa006000.72800586
87Fructose and mannose metabolism_Homo sapiens_hsa000510.72443991
88Cyanoamino acid metabolism_Homo sapiens_hsa004600.70640699
89Arachidonic acid metabolism_Homo sapiens_hsa005900.67621731
90Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.66717965
91Retinol metabolism_Homo sapiens_hsa008300.65693263
92Salmonella infection_Homo sapiens_hsa051320.64518458
93Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.63263865
94NOD-like receptor signaling pathway_Homo sapiens_hsa046210.62978443
95Shigellosis_Homo sapiens_hsa051310.62273984
96Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.62263466
97Influenza A_Homo sapiens_hsa051640.61792187
98B cell receptor signaling pathway_Homo sapiens_hsa046620.58904817
99Fatty acid elongation_Homo sapiens_hsa000620.57568161
100Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.57541135
101Vibrio cholerae infection_Homo sapiens_hsa051100.57279418
102Jak-STAT signaling pathway_Homo sapiens_hsa046300.57179583
103Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.57009309
104Protein digestion and absorption_Homo sapiens_hsa049740.56493769
105Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54995025
106Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.54942429
107Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.53951652
108Collecting duct acid secretion_Homo sapiens_hsa049660.53729462
109Hepatitis C_Homo sapiens_hsa051600.53285445
110Pancreatic secretion_Homo sapiens_hsa049720.51841311
111Selenocompound metabolism_Homo sapiens_hsa004500.50906665
112Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48757359
113Fatty acid biosynthesis_Homo sapiens_hsa000610.48250718
114Insulin resistance_Homo sapiens_hsa049310.44743749
115Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.38629007
116Glycerophospholipid metabolism_Homo sapiens_hsa005640.37822860
117Metabolic pathways_Homo sapiens_hsa011000.36979920
118Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.35407491
119Insulin secretion_Homo sapiens_hsa049110.32775598
120Circadian rhythm_Homo sapiens_hsa047100.32114746
121Glucagon signaling pathway_Homo sapiens_hsa049220.29875407
122Renin secretion_Homo sapiens_hsa049240.29158556
123Prion diseases_Homo sapiens_hsa050200.25862518
124Type I diabetes mellitus_Homo sapiens_hsa049400.24318007
125Amoebiasis_Homo sapiens_hsa051460.23205039
126Ovarian steroidogenesis_Homo sapiens_hsa049130.22105510
127African trypanosomiasis_Homo sapiens_hsa051430.21607472
128Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.19513759
129Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.19483108

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