SMPDL3B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1embryonic process involved in female pregnancy (GO:0060136)8.18460715
2transcription from mitochondrial promoter (GO:0006390)8.18253052
3proline metabolic process (GO:0006560)8.12688125
4replication fork processing (GO:0031297)7.52150503
5positive regulation of protein homooligomerization (GO:0032464)7.05449759
6regulation of integrin activation (GO:0033623)6.91056029
7DNA deamination (GO:0045006)6.27336339
8establishment of apical/basal cell polarity (GO:0035089)6.20751840
9maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)6.08628755
10oxidative demethylation (GO:0070989)6.08336468
11regulation of protein homooligomerization (GO:0032462)5.99897653
12DNA strand renaturation (GO:0000733)5.48367028
13mitochondrial DNA metabolic process (GO:0032042)5.43117270
14establishment or maintenance of monopolar cell polarity (GO:0061339)5.32293986
15establishment of monopolar cell polarity (GO:0061162)5.32293986
16somatic hypermutation of immunoglobulin genes (GO:0016446)5.30312365
17somatic diversification of immune receptors via somatic mutation (GO:0002566)5.30312365
18mitotic G1 DNA damage checkpoint (GO:0031571)5.09532598
19establishment of integrated proviral latency (GO:0075713)5.08848450
20poly(A)+ mRNA export from nucleus (GO:0016973)4.97545650
21cellular response to ATP (GO:0071318)4.91249305
22mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.89995956
23negative regulation of JAK-STAT cascade (GO:0046426)4.88499390
24embryonic placenta development (GO:0001892)4.74147601
25L-serine metabolic process (GO:0006563)4.72706849
26viral mRNA export from host cell nucleus (GO:0046784)4.59428275
27G1 DNA damage checkpoint (GO:0044783)4.51952858
28mitotic G1/S transition checkpoint (GO:0044819)4.50058721
29regulation of translational fidelity (GO:0006450)4.46800799
30mRNA cleavage (GO:0006379)4.42273863
31formation of translation preinitiation complex (GO:0001731)4.39970025
32establishment of protein localization to mitochondrial membrane (GO:0090151)4.35064037
33positive regulation of protein oligomerization (GO:0032461)4.30513360
34negative regulation of cell cycle arrest (GO:0071157)4.30260288
35glutamine family amino acid biosynthetic process (GO:0009084)4.25687327
36cellular response to zinc ion (GO:0071294)4.25377745
37negative regulation of fatty acid biosynthetic process (GO:0045717)4.24173500
38DNA integration (GO:0015074)4.23880216
39negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.12993117
40spliceosomal tri-snRNP complex assembly (GO:0000244)4.06086796
41labyrinthine layer development (GO:0060711)4.04366348
42negative regulation of Ras GTPase activity (GO:0034261)4.03140414
43base-excision repair (GO:0006284)4.00707455
44positive regulation of developmental pigmentation (GO:0048087)4.00471242
45IMP biosynthetic process (GO:0006188)3.99852867
46negative regulation of protein oligomerization (GO:0032460)3.97678606
47DNA strand elongation involved in DNA replication (GO:0006271)3.95656935
48pseudouridine synthesis (GO:0001522)3.93973276
49regulation of protein oligomerization (GO:0032459)3.93928965
50ATP synthesis coupled proton transport (GO:0015986)3.90520931
51energy coupled proton transport, down electrochemical gradient (GO:0015985)3.90520931
52positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.90239586
53positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.90239586
54positive regulation of mitotic sister chromatid separation (GO:1901970)3.90239586
55protein complex localization (GO:0031503)3.87457826
56embryonic camera-type eye development (GO:0031076)3.86405679
57regulation of helicase activity (GO:0051095)3.84478543
58L-alpha-amino acid transmembrane transport (GO:1902475)3.82357944
59trophectodermal cell differentiation (GO:0001829)3.80284906
60face development (GO:0060324)3.80018901
61apoptotic process involved in morphogenesis (GO:0060561)3.78792969
62DNA strand elongation (GO:0022616)3.75918779
63establishment of viral latency (GO:0019043)3.75752897
64telomere maintenance via semi-conservative replication (GO:0032201)3.73889808
65glial cell migration (GO:0008347)3.73782785
66non-recombinational repair (GO:0000726)3.73161522
67double-strand break repair via nonhomologous end joining (GO:0006303)3.73161522
68chaperone-mediated protein transport (GO:0072321)3.69865238
69negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.66547995
70dosage compensation (GO:0007549)3.66200380
71DNA double-strand break processing (GO:0000729)3.65812530
72regulation of sister chromatid cohesion (GO:0007063)3.65789091
73purine nucleobase biosynthetic process (GO:0009113)3.65141478
74regulation of podosome assembly (GO:0071801)3.64060522
75regulation of mitochondrial translation (GO:0070129)3.63120118
76positive regulation by host of viral transcription (GO:0043923)3.62865466
77mitochondrial RNA metabolic process (GO:0000959)3.58400821
78regulation of double-strand break repair via homologous recombination (GO:0010569)3.55816887
79nucleobase biosynthetic process (GO:0046112)3.55675856
80meiotic chromosome segregation (GO:0045132)3.55076775
81convergent extension (GO:0060026)3.55066568
82heterochromatin organization (GO:0070828)3.54800794
83regulation of RNA export from nucleus (GO:0046831)3.52818181
84nucleotide-excision repair, DNA gap filling (GO:0006297)3.51678133
85chromatin remodeling at centromere (GO:0031055)3.51548145
86anatomical structure regression (GO:0060033)3.49988932
87IMP metabolic process (GO:0046040)3.49200780
88base-excision repair, AP site formation (GO:0006285)3.48470776
89histone H4-K12 acetylation (GO:0043983)3.47901431
90GDP-mannose metabolic process (GO:0019673)3.44934005
91respiratory chain complex IV assembly (GO:0008535)3.41669694
92histone arginine methylation (GO:0034969)3.41444800
93negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.39263651
94CENP-A containing nucleosome assembly (GO:0034080)3.38770846
95nodal signaling pathway (GO:0038092)3.36851956
96ribosome assembly (GO:0042255)3.35490750
97serine family amino acid biosynthetic process (GO:0009070)3.33867567
98pre-miRNA processing (GO:0031054)3.33467785
99DNA topological change (GO:0006265)3.32992295
100pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.31949796
101activation of Rac GTPase activity (GO:0032863)3.27777294
102oxidative phosphorylation (GO:0006119)3.27096335
103negative regulation of mRNA processing (GO:0050686)3.25728174
104rRNA modification (GO:0000154)3.24660408
105regulation of posttranscriptional gene silencing (GO:0060147)3.24499755
106regulation of gene silencing by miRNA (GO:0060964)3.24499755
107regulation of gene silencing by RNA (GO:0060966)3.24499755
108protein targeting to vacuole (GO:0006623)3.23970875
109protein targeting to lysosome (GO:0006622)3.23970875
110establishment of protein localization to vacuole (GO:0072666)3.23970875
111regulation of double-strand break repair (GO:2000779)3.23946013
112termination of RNA polymerase II transcription (GO:0006369)3.23760662
113positive regulation of DNA repair (GO:0045739)3.23738873
114DNA replication checkpoint (GO:0000076)3.23381976
115mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.21934346
116proteasome assembly (GO:0043248)3.21498375
117protein localization to kinetochore (GO:0034501)3.20330829
118maturation of 5.8S rRNA (GO:0000460)3.18592139
119DNA demethylation (GO:0080111)3.18362588
120hypotonic response (GO:0006971)3.18023643
121DNA unwinding involved in DNA replication (GO:0006268)3.17957958
122spliceosomal snRNP assembly (GO:0000387)3.16667242
123negative regulation of telomerase activity (GO:0051974)3.15367146
124regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.14016239
125regulation of mitotic spindle checkpoint (GO:1903504)3.14016239
126negative regulation of ligase activity (GO:0051352)3.12418728
127negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.12418728
128regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.12118643
129mitotic nuclear envelope reassembly (GO:0007084)3.10360008
130nuclear envelope reassembly (GO:0031468)3.10360008
131lung-associated mesenchyme development (GO:0060484)3.10106591
132respiratory electron transport chain (GO:0022904)3.10088063
133mitotic metaphase plate congression (GO:0007080)3.08709966
134negative regulation of heart rate (GO:0010459)3.08673532
135regulation of cAMP-dependent protein kinase activity (GO:2000479)3.08374173
136negative regulation of tumor necrosis factor production (GO:0032720)3.07756152
137signal complex assembly (GO:0007172)3.07674520
138DNA replication initiation (GO:0006270)3.07430585
139regulation of cell size (GO:0008361)3.05308995
140termination of RNA polymerase III transcription (GO:0006386)3.04203593
141transcription elongation from RNA polymerase III promoter (GO:0006385)3.04203593
142cytochrome complex assembly (GO:0017004)3.03289711
143mitochondrial respiratory chain complex assembly (GO:0033108)3.03243619
144electron transport chain (GO:0022900)3.02290600
145protein complex biogenesis (GO:0070271)3.01494477
146folic acid-containing compound biosynthetic process (GO:0009396)3.01283181
147kinetochore assembly (GO:0051382)3.01011288
148telomere maintenance via recombination (GO:0000722)3.00401827
149positive regulation of receptor recycling (GO:0001921)2.98607625
150alkaloid metabolic process (GO:0009820)2.98551875
151DNA ligation (GO:0006266)2.97781177
152peptidyl-histidine modification (GO:0018202)2.97631392
153histone exchange (GO:0043486)2.97205289
154DNA replication-dependent nucleosome organization (GO:0034723)2.96790874
155DNA replication-dependent nucleosome assembly (GO:0006335)2.96790874
156water-soluble vitamin biosynthetic process (GO:0042364)2.96336791
157bundle of His cell to Purkinje myocyte communication (GO:0086069)2.96273446
158DNA damage response, detection of DNA damage (GO:0042769)2.96070432
159DNA replication-independent nucleosome organization (GO:0034724)2.95415539
160DNA replication-independent nucleosome assembly (GO:0006336)2.95415539
161regulation of cell fate specification (GO:0042659)2.88407429
162negative regulation of sister chromatid segregation (GO:0033046)2.87500299
163negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.87500299
164negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.87500299
165negative regulation of mitotic sister chromatid segregation (GO:0033048)2.87500299
166negative regulation of mitotic sister chromatid separation (GO:2000816)2.87500299
167telomere maintenance via telomerase (GO:0007004)2.86901663
168rRNA transcription (GO:0009303)2.85477780
169negative regulation of chromosome segregation (GO:0051985)2.85378913
170ribosome biogenesis (GO:0042254)2.83955141
171tRNA aminoacylation for protein translation (GO:0006418)2.83645932
172cellular protein complex localization (GO:0034629)2.83216432
173cullin deneddylation (GO:0010388)2.83195011
174anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.81718853
175maturation of SSU-rRNA (GO:0030490)2.80032511
176amino acid activation (GO:0043038)2.79898043
177tRNA aminoacylation (GO:0043039)2.79898043
178rRNA processing (GO:0006364)2.79842052
179telomere maintenance via telomere lengthening (GO:0010833)2.78907090
180negative regulation of cell fate commitment (GO:0010454)2.78892172
181pteridine-containing compound biosynthetic process (GO:0042559)2.78364690
182positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.77062306
183protein targeting to mitochondrion (GO:0006626)2.76231021
184regulation of nuclear cell cycle DNA replication (GO:0033262)2.74755117
185protein deneddylation (GO:0000338)2.73314306
186peptidyl-arginine omega-N-methylation (GO:0035247)2.71885221
187ribonucleoprotein complex biogenesis (GO:0022613)2.70685511
188proline biosynthetic process (GO:0006561)10.7581576

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.43939520
2SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.50114148
3KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.40797349
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.40797349
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.40797349
6ZFP281_18358816_ChIP-ChIP_MESCs_Mouse3.25654317
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.20595310
8HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.16269683
9GABP_17652178_ChIP-ChIP_JURKAT_Human3.06393811
10RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.96784949
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.87947108
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.79275511
13SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.70534669
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.67414297
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.67316613
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.66254601
17NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.65722726
18SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.55211073
19MYC_18555785_ChIP-Seq_MESCs_Mouse2.52931702
20NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.42081325
21VDR_21846776_ChIP-Seq_THP-1_Human2.37515136
22KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.31044872
23CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.26562836
24POU5F1_16518401_ChIP-PET_MESCs_Mouse2.19689164
25DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.17958395
26PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.16845796
27MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.16618003
28XRN2_22483619_ChIP-Seq_HELA_Human2.14945823
29POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.07685094
30* TCF3_18692474_ChIP-Seq_MESCs_Mouse2.06814419
31E2F7_22180533_ChIP-Seq_HELA_Human2.05704517
32AR_21909140_ChIP-Seq_LNCAP_Human2.02607703
33TCF3_18692474_ChIP-Seq_MEFs_Mouse2.01687335
34* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.01502946
35STAT3_1855785_ChIP-Seq_MESCs_Mouse2.00750718
36EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.00690901
37HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.00159384
38FOXP3_21729870_ChIP-Seq_TREG_Human1.97331339
39NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.96755411
40LXR_22292898_ChIP-Seq_THP-1_Human1.94192212
41SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.90610201
42TTF2_22483619_ChIP-Seq_HELA_Human1.89338940
43ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.86238438
44* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.81410899
45DCP1A_22483619_ChIP-Seq_HELA_Human1.80027671
46ERG_21242973_ChIP-ChIP_JURKAT_Human1.77275393
47PU.1_20513432_ChIP-Seq_Bcells_Mouse1.75851305
48E2F1_21310950_ChIP-Seq_MCF-7_Human1.74578809
49FOXM1_23109430_ChIP-Seq_U2OS_Human1.71979284
50ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.70957037
51YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.70826521
52NANOG_21062744_ChIP-ChIP_HESCs_Human1.69788388
53MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.69457286
54MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.66543052
55* SRF_21415370_ChIP-Seq_HL-1_Mouse1.65678789
56ZFX_18555785_ChIP-Seq_MESCs_Mouse1.64311107
57NANOG_18555785_ChIP-Seq_MESCs_Mouse1.64207325
58NANOG_16153702_ChIP-ChIP_HESCs_Human1.62788899
59TP63_17297297_ChIP-ChIP_HaCaT_Human1.62645938
60NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.62291892
61* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.58062152
62EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.53970857
63ELK1_19687146_ChIP-ChIP_HELA_Human1.52792561
64ZNF263_19887448_ChIP-Seq_K562_Human1.52127196
65VDR_23849224_ChIP-Seq_CD4+_Human1.52020706
66KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.50925107
67NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.50464345
68HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.48940709
69KLF4_18555785_ChIP-Seq_MESCs_Mouse1.48739823
70ESR1_15608294_ChIP-ChIP_MCF-7_Human1.48406529
71* RACK7_27058665_Chip-Seq_MCF-7_Human1.46425103
72CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.44937299
73TET1_21451524_ChIP-Seq_MESCs_Mouse1.44761767
74* CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.44726189
75HOXB4_20404135_ChIP-ChIP_EML_Mouse1.44085228
76SOX2_16153702_ChIP-ChIP_HESCs_Human1.43363618
77MYC_22102868_ChIP-Seq_BL_Human1.43048915
78PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.41290501
79PADI4_21655091_ChIP-ChIP_MCF-7_Human1.39945164
80* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.39255441
81FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.38773365
82POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.38640065
83MYC_18940864_ChIP-ChIP_HL60_Human1.36577760
84KDM5A_27292631_Chip-Seq_BREAST_Human1.35036388
85* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.33698431
86SOX2_18692474_ChIP-Seq_MEFs_Mouse1.31948809
87ZFP281_27345836_Chip-Seq_ESCs_Mouse1.31203104
88NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.28787214
89POU5F1_16153702_ChIP-ChIP_HESCs_Human1.28684100
90NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.28029273
91* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.27890075
92* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.26773547
93* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.25584870
94FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.25091195
95OCT4_18692474_ChIP-Seq_MEFs_Mouse1.24918197
96YY1_21170310_ChIP-Seq_MESCs_Mouse1.24425784
97KDM2B_26808549_Chip-Seq_SUP-B15_Human1.22766837
98RXRA_24833708_ChIP-Seq_LIVER_Mouse1.22309166
99RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.22108914
100KDM2B_26808549_Chip-Seq_DND41_Human1.22053009
101* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.21554576
102BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.20144204
103SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19928790
104ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.18645541
105MYCN_18555785_ChIP-Seq_MESCs_Mouse1.18213213
106PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18130079
107ETS1_21867929_ChIP-Seq_TH2_Mouse1.18010864
108CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.17403379
109KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.15437415
110PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.15373341
111POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.14999704
112THAP11_20581084_ChIP-Seq_MESCs_Mouse1.14933667
113ELK3_25401928_ChIP-Seq_HUVEC_Human1.14883802
114JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.14859954
115KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.14517726
116CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.13544974
117EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.12915440
118NANOG_18692474_ChIP-Seq_MEFs_Mouse1.11653506
119TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10934376
120SRY_22984422_ChIP-ChIP_TESTIS_Rat1.10508479
121CTCF_21964334_ChIP-Seq_BJAB-B_Human1.09196727
122SALL1_21062744_ChIP-ChIP_HESCs_Human1.09192533
123DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.08825465
124* RARB_24833708_ChIP-Seq_LIVER_Mouse1.08762636
125CDX2_20551321_ChIP-Seq_CACO-2_Human1.08661327
126SOX2_18555785_ChIP-Seq_MESCs_Mouse1.07622224
127SPI1_26923725_Chip-Seq_HPCs_Mouse1.07435234
128E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05314811
129P300_27058665_Chip-Seq_ZR-75-30cells_Human1.05282806
130CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.05107402
131TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.04760615
132RARA_24833708_ChIP-Seq_LIVER_Mouse1.04741673
133NELFA_20434984_ChIP-Seq_ESCs_Mouse1.04165780
134* NANOG_16518401_ChIP-PET_MESCs_Mouse1.02815405
135PHF8_20622854_ChIP-Seq_HELA_Human1.02474532
136CTCF_27219007_Chip-Seq_ERYTHROID_Human1.02380063
137BCOR_27268052_Chip-Seq_Bcells_Human1.02344159
138KAP1_27257070_Chip-Seq_ESCs_Mouse1.01378685
139SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.01088034
140TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.00785430
141KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.00725755
142CHD1_26751641_Chip-Seq_LNCaP_Human1.00670895
143CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.00627587
144TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98912705
145GABP_19822575_ChIP-Seq_HepG2_Human0.97908869
146* CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.91638140
147ERG_20887958_ChIP-Seq_HPC-7_Mouse0.91497693
148SOX17_20123909_ChIP-Seq_XEN_Mouse0.90059613
149CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.89289202
150ELF1_17652178_ChIP-ChIP_JURKAT_Human0.89030902
151CTCF_18555785_ChIP-Seq_MESCs_Mouse0.80587589
152ELF5_23300383_ChIP-Seq_T47D_Human0.80471770
153SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.80034684
154SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.79607568
155TBX5_21415370_ChIP-Seq_HL-1_Mouse0.78963988

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication6.00400647
2MP0002254_reproductive_system_inflammat4.91316233
3MP0005171_absent_coat_pigmentation4.73495098
4MP0009278_abnormal_bone_marrow4.68725103
5MP0010030_abnormal_orbit_morphology3.91670284
6MP0002009_preneoplasia3.30401146
7MP0004233_abnormal_muscle_weight3.17373585
8MP0001188_hyperpigmentation2.71256977
9MP0009672_abnormal_birth_weight2.44332587
10MP0006035_abnormal_mitochondrial_morpho2.36627130
11MP0008995_early_reproductive_senescence2.34931170
12MP0003283_abnormal_digestive_organ2.33115221
13MP0001545_abnormal_hematopoietic_system2.27288381
14MP0005397_hematopoietic_system_phenotyp2.27288381
15MP0010352_gastrointestinal_tract_polyps2.24649868
16MP0003890_abnormal_embryonic-extraembry2.23069872
17MP0010094_abnormal_chromosome_stability2.13704964
18MP0005076_abnormal_cell_differentiation2.11446186
19MP0003453_abnormal_keratinocyte_physiol2.09326859
20MP0004133_heterotaxia2.05821345
21MP0004957_abnormal_blastocyst_morpholog1.99080415
22MP0005174_abnormal_tail_pigmentation1.98245559
23MP0003119_abnormal_digestive_system1.95284804
24MP0003786_premature_aging1.94567953
25MP0003806_abnormal_nucleotide_metabolis1.90583702
26MP0008007_abnormal_cellular_replicative1.89454254
27MP0002282_abnormal_trachea_morphology1.82831197
28MP0002653_abnormal_ependyma_morphology1.78343912
29MP0000537_abnormal_urethra_morphology1.78042816
30MP0002249_abnormal_larynx_morphology1.75676443
31MP0005058_abnormal_lysosome_morphology1.75561080
32MP0003172_abnormal_lysosome_physiology1.73602945
33MP0002086_abnormal_extraembryonic_tissu1.71489689
34MP0006072_abnormal_retinal_apoptosis1.62117162
35MP0000579_abnormal_nail_morphology1.60043407
36MP0010234_abnormal_vibrissa_follicle1.59621530
37MP0001293_anophthalmia1.58009424
38MP0000490_abnormal_crypts_of1.56600422
39MP0003111_abnormal_nucleus_morphology1.55870650
40MP0004782_abnormal_surfactant_physiolog1.53942623
41MP0002084_abnormal_developmental_patter1.53520996
42MP0000371_diluted_coat_color1.51274434
43MP0003123_paternal_imprinting1.49740001
44MP0008058_abnormal_DNA_repair1.49191881
45MP0001697_abnormal_embryo_size1.48728403
46MP0006292_abnormal_olfactory_placode1.45899330
47MP0004197_abnormal_fetal_growth/weight/1.45448850
48MP0000678_abnormal_parathyroid_gland1.43981556
49MP0009697_abnormal_copulation1.42393084
50MP0008932_abnormal_embryonic_tissue1.40298560
51MP0002796_impaired_skin_barrier1.40068554
52MP0002697_abnormal_eye_size1.37772593
53MP0003567_abnormal_fetal_cardiomyocyte1.36954727
54MP0000470_abnormal_stomach_morphology1.36944871
55MP0002085_abnormal_embryonic_tissue1.36426871
56MP0002277_abnormal_respiratory_mucosa1.32624151
57MP0000015_abnormal_ear_pigmentation1.32075712
58MP0000566_synostosis1.30938923
59MP0003186_abnormal_redox_activity1.26328665
60MP0008877_abnormal_DNA_methylation1.26221103
61MP0003828_pulmonary_edema1.25344493
62MP0000462_abnormal_digestive_system1.24003387
63MP0001672_abnormal_embryogenesis/_devel1.22476539
64MP0005380_embryogenesis_phenotype1.22476539
65MP0003937_abnormal_limbs/digits/tail_de1.21396544
66MP0006082_CNS_inflammation1.21311636
67MP0002269_muscular_atrophy1.19634737
68MP0004147_increased_porphyrin_level1.19212401
69MP0006036_abnormal_mitochondrial_physio1.19181631
70MP0003693_abnormal_embryo_hatching1.16655002
71MP0003077_abnormal_cell_cycle1.16077090
72MP0003045_fibrosis1.13963886
73MP0010307_abnormal_tumor_latency1.12688310
74MP0002111_abnormal_tail_morphology1.11667433
75MP0005075_abnormal_melanosome_morpholog1.11532664
76MP0009379_abnormal_foot_pigmentation1.11282702
77MP0010386_abnormal_urinary_bladder1.10968527
78MP0004264_abnormal_extraembryonic_tissu1.10666312
79MP0004742_abnormal_vestibular_system1.10220228
80MP0001485_abnormal_pinna_reflex1.08913010
81MP0000350_abnormal_cell_proliferation1.08435258
82MP0001340_abnormal_eyelid_morphology1.08071135
83MP0001881_abnormal_mammary_gland1.07175216
84MP0003315_abnormal_perineum_morphology1.07019817
85MP0000049_abnormal_middle_ear1.05983390
86MP0003705_abnormal_hypodermis_morpholog1.04275462
87MP0001730_embryonic_growth_arrest1.03321619
88MP0001666_abnormal_nutrient_absorption1.03137519
89MP0000685_abnormal_immune_system1.00681319
90MP0000639_abnormal_adrenal_gland0.99769787
91MP0000762_abnormal_tongue_morphology0.99664831
92MP0003718_maternal_effect0.98806702
93MP0002019_abnormal_tumor_incidence0.98159508
94MP0000358_abnormal_cell_content/0.97337070
95MP0009703_decreased_birth_body0.96064852
96MP0001849_ear_inflammation0.96010896
97MP0009333_abnormal_splenocyte_physiolog0.92739021
98MP0002060_abnormal_skin_morphology0.92566732
99MP0000627_abnormal_mammary_gland0.92043824
100MP0003984_embryonic_growth_retardation0.91623601
101MP0002080_prenatal_lethality0.91303100
102MP0003566_abnormal_cell_adhesion0.88848118
103MP0002405_respiratory_system_inflammati0.88641646
104MP0002088_abnormal_embryonic_growth/wei0.87274529
105MP0003755_abnormal_palate_morphology0.87198495
106MP0005501_abnormal_skin_physiology0.86777130
107MP0005220_abnormal_exocrine_pancreas0.86424557
108MP0002932_abnormal_joint_morphology0.86187491
109MP0009115_abnormal_fat_cell0.86034504
110MP0005332_abnormal_amino_acid0.85621243
111MP0005266_abnormal_metabolism0.84412595
112MP0002075_abnormal_coat/hair_pigmentati0.84364710
113MP0002332_abnormal_exercise_endurance0.83828902
114MP0001661_extended_life_span0.82989249
115MP0002234_abnormal_pharynx_morphology0.82926314
116MP0000516_abnormal_urinary_system0.82015550
117MP0005367_renal/urinary_system_phenotyp0.82015550
118MP0001286_abnormal_eye_development0.80267802
119MP0008875_abnormal_xenobiotic_pharmacok0.78905294
120MP0001324_abnormal_eye_pigmentation0.78513853
121MP0005023_abnormal_wound_healing0.78453077
122MP0002736_abnormal_nociception_after0.78389646
123MP0003935_abnormal_craniofacial_develop0.77561580
124MP0005395_other_phenotype0.77092450
125MP0000467_abnormal_esophagus_morphology0.76938709
126MP0001145_abnormal_male_reproductive0.76614676
127MP0009053_abnormal_anal_canal0.76424631
128MP0002114_abnormal_axial_skeleton0.76246903
129MP0005085_abnormal_gallbladder_physiolo0.75689072
130MP0000432_abnormal_head_morphology0.74977232
131MP0002090_abnormal_vision0.74037580
132MP0000313_abnormal_cell_death0.73281176
133MP0003878_abnormal_ear_physiology0.72690882
134MP0005377_hearing/vestibular/ear_phenot0.72690882
135MP0002006_tumorigenesis0.72671277
136MP0001764_abnormal_homeostasis0.72390856
137MP0001186_pigmentation_phenotype0.71830109
138MP0003941_abnormal_skin_development0.71787751
139MP0005508_abnormal_skeleton_morphology0.71306986
140MP0002233_abnormal_nose_morphology0.70797376
141MP0004019_abnormal_vitamin_homeostasis0.70765841
142MP0003121_genomic_imprinting0.68992452
143MP0000477_abnormal_intestine_morphology0.68803629
144MP0003938_abnormal_ear_development0.68514538
145MP0010771_integument_phenotype0.68429456
146MP0003137_abnormal_impulse_conducting0.68355875
147MP0002166_altered_tumor_susceptibility0.67066767
148MP0002116_abnormal_craniofacial_bone0.66947049
149MP0003787_abnormal_imprinting0.66438934
150MP0010630_abnormal_cardiac_muscle0.65801846
151MP0001919_abnormal_reproductive_system0.65724915
152MP0002938_white_spotting0.65082092
153MP0002163_abnormal_gland_morphology0.62305660
154MP0002098_abnormal_vibrissa_morphology0.62154918
155MP0002210_abnormal_sex_determination0.60428280
156MP0008872_abnormal_physiological_respon0.59763428

Predicted human phenotypes

RankGene SetZ-score
1Pustule (HP:0200039)5.52893785
2Rib fusion (HP:0000902)5.44901007
3Concave nail (HP:0001598)5.37320834
4Increased IgM level (HP:0003496)5.07555868
5Annular pancreas (HP:0001734)5.01386418
6Rectal fistula (HP:0100590)5.00776438
7Rectovaginal fistula (HP:0000143)5.00776438
8Alopecia of scalp (HP:0002293)4.79226097
9Facial hemangioma (HP:0000329)4.77628570
10Poikiloderma (HP:0001029)4.51500214
11Intestinal fistula (HP:0100819)4.50625680
12Turricephaly (HP:0000262)4.50094355
13Vaginal fistula (HP:0004320)4.43367590
14Ulnar bowing (HP:0003031)4.36320925
15Hypochromic microcytic anemia (HP:0004840)4.34267556
16Aplasia/Hypoplasia involving the carpal bones (HP:0006502)4.12823387
17Short humerus (HP:0005792)4.05213477
18Aplasia/hypoplasia of the humerus (HP:0006507)3.91977298
19Coronal craniosynostosis (HP:0004440)3.87938991
20Tongue fasciculations (HP:0001308)3.87905176
21Acute necrotizing encephalopathy (HP:0006965)3.85630188
22Male infertility (HP:0003251)3.76307845
23Acute encephalopathy (HP:0006846)3.75351813
24Colon cancer (HP:0003003)3.74788970
25Abnormal hemoglobin (HP:0011902)3.69719821
26Abnormal mitochondria in muscle tissue (HP:0008316)3.64134643
27Aplasia/Hypoplasia of the vertebrae (HP:0008515)3.57334711
28Vertebral hypoplasia (HP:0008417)3.57334711
29Muscle fibrillation (HP:0010546)3.56287360
30Orthostatic hypotension (HP:0001278)3.55210238
31Intestinal atresia (HP:0011100)3.38478354
32Abnormality of male internal genitalia (HP:0000022)3.36481079
33Absent radius (HP:0003974)3.36163886
34Increased hepatocellular lipid droplets (HP:0006565)3.33930267
35Mucopolysacchariduria (HP:0008155)3.30487699
36Urinary glycosaminoglycan excretion (HP:0003541)3.30487699
37Mitochondrial inheritance (HP:0001427)3.21016750
38Anteriorly placed anus (HP:0001545)3.19941124
39Absent forearm bone (HP:0003953)3.16773384
40Aplasia involving forearm bones (HP:0009822)3.16773384
41Lipid accumulation in hepatocytes (HP:0006561)3.11786171
42Alacrima (HP:0000522)3.07284216
43Dysostosis multiplex (HP:0000943)3.03298106
44Congenital hip dislocation (HP:0001374)3.01918077
45Short chin (HP:0000331)3.00746121
46Increased CSF lactate (HP:0002490)2.96343765
47Abnormality of mucopolysaccharide metabolism (HP:0011020)2.95518867
48Abnormality of polysaccharide metabolism (HP:0011012)2.95518867
49Abnormality of glycosaminoglycan metabolism (HP:0004371)2.95518867
50Squamous cell carcinoma (HP:0002860)2.93820058
51Progressive macrocephaly (HP:0004481)2.93813672
52Albinism (HP:0001022)2.93773666
53Abnormality of the aortic arch (HP:0012303)2.93080941
54Hypotrichosis (HP:0001006)2.87744961
55Birth length less than 3rd percentile (HP:0003561)2.86404659
56Abnormality of methionine metabolism (HP:0010901)2.85618992
57Multiple enchondromatosis (HP:0005701)2.85487488
58Decreased activity of mitochondrial respiratory chain (HP:0008972)2.84932436
59Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.84932436
60Spastic diplegia (HP:0001264)2.81063761
61Dysautonomia (HP:0002459)2.81043481
62Absent thumb (HP:0009777)2.80992698
63Cerebral edema (HP:0002181)2.80347317
64Premature skin wrinkling (HP:0100678)2.80237636
65Broad alveolar ridges (HP:0000187)2.76029213
66Basal cell carcinoma (HP:0002671)2.75692831
67Diaphragmatic weakness (HP:0009113)2.75399542
68Chronic bronchitis (HP:0004469)2.74888926
69Right ventricular cardiomyopathy (HP:0011663)2.74207167
70Type I transferrin isoform profile (HP:0003642)2.73708669
71Megaloblastic anemia (HP:0001889)2.70416408
72Hyperglycinuria (HP:0003108)2.69366963
73Pili torti (HP:0003777)2.68622595
74Renal Fanconi syndrome (HP:0001994)2.68401254
75Hypochromic anemia (HP:0001931)2.67959390
76Large for gestational age (HP:0001520)2.64974707
77Hypoglycemic seizures (HP:0002173)2.64688376
78Aplasia of the musculature (HP:0100854)2.63344070
79Hepatocellular necrosis (HP:0001404)2.63011075
80Abnormality of aspartate family amino acid metabolism (HP:0010899)2.62916701
81Sensory axonal neuropathy (HP:0003390)2.59154584
82Joint stiffness (HP:0001387)2.58308174
83Hypokinesia (HP:0002375)2.58293045
84Hyperinsulinemic hypoglycemia (HP:0000825)2.57702059
85Hyperglycinemia (HP:0002154)2.56575988
86Selective tooth agenesis (HP:0001592)2.55499652
87Clumsiness (HP:0002312)2.54250969
88Hamartoma (HP:0010566)2.53505365
89Abnormality of glycine metabolism (HP:0010895)2.52978718
90Abnormality of serine family amino acid metabolism (HP:0010894)2.52978718
91Cerebral aneurysm (HP:0004944)2.52653144
92Abnormality of homocysteine metabolism (HP:0010919)2.50829656
93Homocystinuria (HP:0002156)2.50829656
94Bifid uvula (HP:0000193)2.50340828
95Patellar aplasia (HP:0006443)2.50147445
96Choanal stenosis (HP:0000452)2.48984197
97Abnormality of serum amino acid levels (HP:0003112)2.48740151
98Premature graying of hair (HP:0002216)2.47217715
99Bowing of the arm (HP:0006488)2.43868255
100Bowed forearm bones (HP:0003956)2.43868255
101Abnormal lung lobation (HP:0002101)2.43558910
102Pancreatic islet-cell hyperplasia (HP:0004510)2.43142031
103Septo-optic dysplasia (HP:0100842)2.41488686
104Increased intramyocellular lipid droplets (HP:0012240)2.40677727
105Vertebral fusion (HP:0002948)2.38817759
106Capillary hemangiomas (HP:0005306)2.38688624
107Microvesicular hepatic steatosis (HP:0001414)2.38423039
108Nephroblastoma (Wilms tumor) (HP:0002667)2.38254161
109Macrocytic anemia (HP:0001972)2.38117906
110Polycythemia (HP:0001901)2.37488342
111Volvulus (HP:0002580)2.37427629
112Hypotelorism (HP:0000601)2.37058403
113IgA deficiency (HP:0002720)2.36463552
114Abnormality of sulfur amino acid metabolism (HP:0004339)2.36111283
115Growth hormone excess (HP:0000845)2.34351336
116Reduced antithrombin III activity (HP:0001976)2.33810804
117Chromosomal breakage induced by crosslinking agents (HP:0003221)2.32511991
118Lactic acidosis (HP:0003128)2.30898974
119Decreased lacrimation (HP:0000633)2.30803062
120Aplasia/Hypoplasia of the patella (HP:0006498)2.30072678
121Chromsome breakage (HP:0040012)2.28168989
122Symptomatic seizures (HP:0011145)2.27736903
123Sparse eyelashes (HP:0000653)2.27360858
124Increased number of teeth (HP:0011069)2.27154684
125Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.24998009
126Hepatic necrosis (HP:0002605)2.24972857
127Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.23013336
128Abnormal protein N-linked glycosylation (HP:0012347)2.23013336
129Abnormal protein glycosylation (HP:0012346)2.23013336
130Abnormal glycosylation (HP:0012345)2.23013336
131Abnormality of the labia minora (HP:0012880)2.22104665
132Cheilitis (HP:0100825)2.21793392
133Degeneration of anterior horn cells (HP:0002398)2.20941849
134Abnormality of the anterior horn cell (HP:0006802)2.20941849
135Reticulocytopenia (HP:0001896)2.18334772
136Amelogenesis imperfecta (HP:0000705)2.17972866
137Hypoglycemic coma (HP:0001325)2.17797581
138Split hand (HP:0001171)2.17770974
139Gout (HP:0001997)2.17694827
140Lower limb hyperreflexia (HP:0002395)2.17096746
141Increased serum lactate (HP:0002151)2.16446151
142Embryonal renal neoplasm (HP:0011794)2.13550186
143Gastrointestinal atresia (HP:0002589)2.11917568
144Exercise intolerance (HP:0003546)2.10445316
145Respiratory failure (HP:0002878)2.09839549
146Progressive muscle weakness (HP:0003323)2.09690374
147Maternal diabetes (HP:0009800)2.08683565
148Abnormality of the pancreatic islet cells (HP:0006476)2.08369041
149Abnormality of endocrine pancreas physiology (HP:0012093)2.08369041
150Popliteal pterygium (HP:0009756)2.08191159
151Acute lymphatic leukemia (HP:0006721)2.06128793
152Absent eyebrow (HP:0002223)2.05957238
153Bulbar palsy (HP:0001283)2.05553681
154Abnormality of the astrocytes (HP:0100707)2.05089755
155Astrocytoma (HP:0009592)2.05089755
156Facial cleft (HP:0002006)2.04206166
157Increased muscle lipid content (HP:0009058)2.03464907
158Meckel diverticulum (HP:0002245)2.01513813
159Spinal muscular atrophy (HP:0007269)2.00743312
160Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.00665918
161Hypoplasia of the radius (HP:0002984)1.98544966
162Narrow nasal bridge (HP:0000446)1.97824695
163Bilateral sensorineural hearing impairment (HP:0008619)1.97748499
164Methylmalonic acidemia (HP:0002912)1.97647679
165Redundant skin (HP:0001582)1.97420878
166Hypoplasia of the ulna (HP:0003022)1.97326053
167Bilateral microphthalmos (HP:0007633)1.96671447
168Neoplasm of the adrenal gland (HP:0100631)1.96414821
169Lethargy (HP:0001254)1.96327669
170Cleft eyelid (HP:0000625)1.96269465
171Abnormality of the preputium (HP:0100587)1.95786609
172Absent eyelashes (HP:0000561)1.95342865
173Abnormality of glycolysis (HP:0004366)1.95290862
174Leukodystrophy (HP:0002415)1.94775786
175Neoplasm of the adrenal cortex (HP:0100641)1.94729739
176Asymmetric septal hypertrophy (HP:0001670)1.94564086
177Myokymia (HP:0002411)1.93202388
178Methylmalonic aciduria (HP:0012120)1.92272269
179Ependymoma (HP:0002888)1.91044553
180Increased serum pyruvate (HP:0003542)1.89527659
181Aplasia/Hypoplasia involving the musculature (HP:0001460)1.87905592
182Generalized amyotrophy (HP:0003700)1.87702947
183Double outlet right ventricle (HP:0001719)1.86892066
184Congenital malformation of the right heart (HP:0011723)1.86892066
185Palmoplantar hyperkeratosis (HP:0000972)1.86771559
186Testicular atrophy (HP:0000029)1.86729669
187Abnormality of the ileum (HP:0001549)1.86586825
188Diminished movement (HP:0002374)1.86392399
189Neoplasm of the colon (HP:0100273)1.82447980
190Short 5th finger (HP:0009237)1.81648024
191Abnormality of renal resorption (HP:0011038)1.81356311
192Abnormality of the lacrimal duct (HP:0011481)1.81312974
193Carpal bone hypoplasia (HP:0001498)1.80398294
194Ragged-red muscle fibers (HP:0003200)1.79991538
195Abnormality of chromosome stability (HP:0003220)1.79454924
196Pancytopenia (HP:0001876)1.73482797

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK6.01736846
2DDR25.38683777
3VRK25.27094730
4MAPK154.62080414
5MAP3K64.56545021
6MAP3K113.70287139
7TAF13.66186877
8MST43.35537114
9FGR3.32795046
10MATK3.19938401
11TYRO33.14823891
12PINK13.12141574
13CDC72.95088792
14SMG12.72663639
15TSSK62.70086678
16BMX2.51009219
17DAPK12.42305779
18CSK2.41594113
19NME12.31522514
20PIM22.30132977
21NME22.26718708
22PBK2.25110985
23NUAK12.24158511
24YES12.15283080
25PDGFRA2.12728648
26PRKD22.09851009
27ZAK2.08415276
28UHMK12.07836927
29SRPK12.00807103
30PLK31.99051914
31DYRK1B1.88663337
32VRK11.86329951
33STK161.79843857
34CDK71.78138136
35TRPM71.70249725
36MKNK11.64014591
37AKT31.62636170
38MKNK21.59094720
39MAP3K121.58223128
40EIF2AK31.53479838
41EIF2AK11.43520838
42CDK61.43306353
43TNIK1.41920506
44PIM11.41028345
45PAK41.37496995
46LATS21.36131537
47RPS6KC11.26557489
48RPS6KL11.26557489
49MST1R1.24778142
50CDC42BPA1.17429974
51CSNK1G31.16139139
52GSK3A1.14064714
53RPS6KA61.09700701
54PLK41.06483521
55PASK1.05085779
56MAPK111.04691061
57PHKG21.02711190
58PHKG11.02711190
59CDK191.01890474
60BRSK20.99643678
61CSNK1A1L0.98103674
62CHEK20.95479379
63STK38L0.93643723
64PRPF4B0.92107645
65EIF2AK20.91452323
66CSNK1G20.90122024
67STK40.86425462
68TAOK20.86332033
69MAP3K100.85798678
70TRIM280.85303070
71PLK10.83469250
72BCKDK0.82288417
73GRK50.81978960
74EPHA20.80696617
75CAMK1D0.79363733
76GRK10.76196465
77DYRK30.74677011
78CDK120.73964856
79PRKCI0.73210076
80PRKG20.70108744
81RPS6KA10.68358606
82MTOR0.66611655
83BRSK10.66004217
84BMPR1B0.65512161
85CSNK1E0.62618894
86PRKAA10.61153830
87HIPK20.57268236
88OXSR10.56994917
89EGFR0.53578969
90CAMK1G0.53523761
91ERBB30.49877343
92TRIB30.49336935
93RAF10.49205979
94ATR0.48737836
95WNK30.48444966
96RPS6KB20.46891881
97PRKDC0.46777439
98TESK10.46251035
99STK30.45359084
100ACVR1B0.45331125
101CDK20.45280470
102RIPK10.44920455
103CSNK1A10.44733834
104LYN0.44316266
105PDGFRB0.43662554
106MAP3K80.42454906
107CSNK2A10.41902339
108MAP3K90.41273865
109MET0.41224519
110NLK0.40887719
111BRAF0.40259445
112AKT20.37654255
113CAMK2G0.35891548
114ALK0.35826282
115DAPK30.35297362
116RPS6KB10.35140673
117NEK20.35086464
118MAPK30.35004824
119MAPKAPK50.34705917
120MAPK10.34558209
121CAMK2B0.34276357
122AURKA0.33366558
123TNK20.32323857
124FER0.32181199
125CDK30.30649455
126RPS6KA40.29990361
127MAPK40.29555317
128INSR0.28993779
129MAP4K20.28764848
130LATS10.28525380
131STK100.28070644
132MAPK100.27860050
133WEE10.27665868
134PRKAA20.27544198
135MAPKAPK20.27060144
136CDK40.26909423
137MAPK140.26820442
138INSRR0.26749098
139PTK60.25686858
140FGFR20.25647061
141CSNK2A20.25606183
142ATM0.25483531
143AURKB0.25426381
144MYLK0.24606140
145PTK20.24567037
146KDR0.24487470
147DMPK0.24086671
148CHEK10.24026530
149IKBKB0.22461505
150CSNK1G10.22325723
151TAOK10.22275868
152NEK10.21491971
153PRKCD0.21368932
154BUB10.20415639
155CDK10.20190090
156CAMK2D0.19827711
157DYRK20.19189299
158PRKCZ0.19122943
159PAK10.18297011
160CHUK0.18118593
161FGFR10.17204239
162MAP4K10.16887607
163LCK0.16150367
164TTK0.16024777
165SGK10.15783081
166ABL10.15098807
167PAK20.14172324

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000615.85614412
2Mismatch repair_Homo sapiens_hsa034304.90158804
3Base excision repair_Homo sapiens_hsa034104.54497640
4DNA replication_Homo sapiens_hsa030303.57149552
5Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.54545023
6Oxidative phosphorylation_Homo sapiens_hsa001902.45104516
7RNA polymerase_Homo sapiens_hsa030202.29013304
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.24060040
9Non-homologous end-joining_Homo sapiens_hsa034502.19349108
10Parkinsons disease_Homo sapiens_hsa050122.18317125
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.17094994
12Cysteine and methionine metabolism_Homo sapiens_hsa002702.13658758
13Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.11834731
14Vitamin B6 metabolism_Homo sapiens_hsa007502.10894354
15Nucleotide excision repair_Homo sapiens_hsa034202.08051618
16mTOR signaling pathway_Homo sapiens_hsa041502.07610433
17Notch signaling pathway_Homo sapiens_hsa043302.01603974
18Arginine and proline metabolism_Homo sapiens_hsa003302.00106525
19Hippo signaling pathway_Homo sapiens_hsa043901.93878199
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.90577817
21RNA transport_Homo sapiens_hsa030131.89321073
22Hedgehog signaling pathway_Homo sapiens_hsa043401.88721286
23Adherens junction_Homo sapiens_hsa045201.86907115
24Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.79838758
25Circadian rhythm_Homo sapiens_hsa047101.79337164
26Spliceosome_Homo sapiens_hsa030401.77854465
27mRNA surveillance pathway_Homo sapiens_hsa030151.77077232
28p53 signaling pathway_Homo sapiens_hsa041151.70096149
29Huntingtons disease_Homo sapiens_hsa050161.69338043
30Selenocompound metabolism_Homo sapiens_hsa004501.69013678
31Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.68516506
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.67521687
33Homologous recombination_Homo sapiens_hsa034401.66210687
34Pyruvate metabolism_Homo sapiens_hsa006201.66154829
35Alzheimers disease_Homo sapiens_hsa050101.55976593
36Fatty acid elongation_Homo sapiens_hsa000621.54320305
37Protein export_Homo sapiens_hsa030601.53269768
38Pyrimidine metabolism_Homo sapiens_hsa002401.52851582
39Fanconi anemia pathway_Homo sapiens_hsa034601.52058634
402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.49965167
41Folate biosynthesis_Homo sapiens_hsa007901.48357584
42Biosynthesis of amino acids_Homo sapiens_hsa012301.46666710
43TGF-beta signaling pathway_Homo sapiens_hsa043501.46179445
44Shigellosis_Homo sapiens_hsa051311.44297972
45Carbon metabolism_Homo sapiens_hsa012001.38912492
46Bladder cancer_Homo sapiens_hsa052191.32114887
47Nitrogen metabolism_Homo sapiens_hsa009101.31596009
48Longevity regulating pathway - mammal_Homo sapiens_hsa042111.29798678
49Transcriptional misregulation in cancer_Homo sapiens_hsa052021.29416460
50Propanoate metabolism_Homo sapiens_hsa006401.28675478
51Vitamin digestion and absorption_Homo sapiens_hsa049771.27537428
52Fructose and mannose metabolism_Homo sapiens_hsa000511.27349288
53Sulfur relay system_Homo sapiens_hsa041221.27238792
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.26586982
55Fatty acid metabolism_Homo sapiens_hsa012121.21696459
56Cell cycle_Homo sapiens_hsa041101.21630570
57Legionellosis_Homo sapiens_hsa051341.16749836
58Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.14723708
59RNA degradation_Homo sapiens_hsa030181.12474178
60Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.09498549
61Pentose phosphate pathway_Homo sapiens_hsa000301.08833057
62Pentose and glucuronate interconversions_Homo sapiens_hsa000401.08747003
63VEGF signaling pathway_Homo sapiens_hsa043701.07765345
64Basal cell carcinoma_Homo sapiens_hsa052171.07682899
65Purine metabolism_Homo sapiens_hsa002301.05525251
66Wnt signaling pathway_Homo sapiens_hsa043101.05070382
67Basal transcription factors_Homo sapiens_hsa030221.04899770
68Sulfur metabolism_Homo sapiens_hsa009201.00943509
69Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.00852319
70Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.95974932
71Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.93950889
72Lysine degradation_Homo sapiens_hsa003100.92383244
73Glycosaminoglycan degradation_Homo sapiens_hsa005310.91599729
74Cyanoamino acid metabolism_Homo sapiens_hsa004600.91105631
75Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.87486834
76Metabolic pathways_Homo sapiens_hsa011000.86349385
77Galactose metabolism_Homo sapiens_hsa000520.84644279
78Colorectal cancer_Homo sapiens_hsa052100.81891948
79Mineral absorption_Homo sapiens_hsa049780.80988325
80Regulation of actin cytoskeleton_Homo sapiens_hsa048100.80832918
81Oocyte meiosis_Homo sapiens_hsa041140.80412982
82Arginine biosynthesis_Homo sapiens_hsa002200.80347124
83Viral myocarditis_Homo sapiens_hsa054160.79314438
84N-Glycan biosynthesis_Homo sapiens_hsa005100.78727233
85MicroRNAs in cancer_Homo sapiens_hsa052060.77814140
86Primary immunodeficiency_Homo sapiens_hsa053400.77664585
87Tight junction_Homo sapiens_hsa045300.75612707
88Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.71402023
89Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.68863181
90Drug metabolism - other enzymes_Homo sapiens_hsa009830.68664562
91Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.65635206
92Maturity onset diabetes of the young_Homo sapiens_hsa049500.64663272
93Cardiac muscle contraction_Homo sapiens_hsa042600.63674156
94Ribosome_Homo sapiens_hsa030100.62364610
95Fatty acid degradation_Homo sapiens_hsa000710.61423210
96Retinol metabolism_Homo sapiens_hsa008300.60888484
97Small cell lung cancer_Homo sapiens_hsa052220.60852280
98Dorso-ventral axis formation_Homo sapiens_hsa043200.60291699
99Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60166379
100Viral carcinogenesis_Homo sapiens_hsa052030.60122921
101Glutathione metabolism_Homo sapiens_hsa004800.59127640
102Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58160511
103Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.57906664
104Chronic myeloid leukemia_Homo sapiens_hsa052200.57258424
105beta-Alanine metabolism_Homo sapiens_hsa004100.54999382
106Peroxisome_Homo sapiens_hsa041460.53995643
107Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53782189
108Herpes simplex infection_Homo sapiens_hsa051680.53522960
109One carbon pool by folate_Homo sapiens_hsa006700.52812718
110Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.52077656
111Acute myeloid leukemia_Homo sapiens_hsa052210.51050780
112Caffeine metabolism_Homo sapiens_hsa002320.51005162
113Choline metabolism in cancer_Homo sapiens_hsa052310.50735804
114Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.50395416
115Tryptophan metabolism_Homo sapiens_hsa003800.49319561
116Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.49052358
117Starch and sucrose metabolism_Homo sapiens_hsa005000.48988050
118Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48906572
119ErbB signaling pathway_Homo sapiens_hsa040120.46602567
120Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.45984394
121Fat digestion and absorption_Homo sapiens_hsa049750.45532498
122Sphingolipid metabolism_Homo sapiens_hsa006000.45253570
123Thyroid cancer_Homo sapiens_hsa052160.44231180
124Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.44220660
125AMPK signaling pathway_Homo sapiens_hsa041520.43023199
126Proteoglycans in cancer_Homo sapiens_hsa052050.42634181
127Proteasome_Homo sapiens_hsa030500.42481890
128Steroid biosynthesis_Homo sapiens_hsa001000.41650903
129Epstein-Barr virus infection_Homo sapiens_hsa051690.39036819
130Gap junction_Homo sapiens_hsa045400.38723910
131Insulin signaling pathway_Homo sapiens_hsa049100.38268044
132Pancreatic secretion_Homo sapiens_hsa049720.36351113
133Chemical carcinogenesis_Homo sapiens_hsa052040.34786652
134Hepatitis B_Homo sapiens_hsa051610.34544197
135Salmonella infection_Homo sapiens_hsa051320.33772310
136Lysosome_Homo sapiens_hsa041420.33630093
137Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.33101206
138Central carbon metabolism in cancer_Homo sapiens_hsa052300.32167993
139Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.30640234
140Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.28811432
141Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.28205687
142Taste transduction_Homo sapiens_hsa047420.28065135
143Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.27588916
144Long-term depression_Homo sapiens_hsa047300.27056013
145Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.26067382
146HTLV-I infection_Homo sapiens_hsa051660.25829679
147Renin-angiotensin system_Homo sapiens_hsa046140.25323476
148Focal adhesion_Homo sapiens_hsa045100.25190529
149HIF-1 signaling pathway_Homo sapiens_hsa040660.23715810
150Measles_Homo sapiens_hsa051620.23656815
151MAPK signaling pathway_Homo sapiens_hsa040100.22645041
152PI3K-Akt signaling pathway_Homo sapiens_hsa041510.22424615
153Endometrial cancer_Homo sapiens_hsa052130.21383004
154Apoptosis_Homo sapiens_hsa042100.19328829
155Endocytosis_Homo sapiens_hsa041440.18808800
156Prostate cancer_Homo sapiens_hsa052150.17456096
157Pathways in cancer_Homo sapiens_hsa052000.16747162
158Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.16431538
159B cell receptor signaling pathway_Homo sapiens_hsa046620.16253970
160Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.14698961

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