SMR3A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of T cell tolerance induction (GO:0002664)9.32802056
2negative regulation of T cell apoptotic process (GO:0070233)9.24887026
3retina homeostasis (GO:0001895)8.36113246
4positive regulation of tolerance induction (GO:0002645)7.90302429
5interferon-gamma secretion (GO:0072643)7.01775021
6regulation of tolerance induction (GO:0002643)6.83202304
7kynurenine metabolic process (GO:0070189)6.39588338
8negative regulation of lymphocyte apoptotic process (GO:0070229)6.12645993
9indole-containing compound catabolic process (GO:0042436)5.56382746
10indolalkylamine catabolic process (GO:0046218)5.56382746
11tryptophan catabolic process (GO:0006569)5.56382746
12regulation of chronic inflammatory response (GO:0002676)5.39889442
13regulation of T cell apoptotic process (GO:0070232)5.02448484
14tryptophan metabolic process (GO:0006568)4.99268881
15hydrogen peroxide catabolic process (GO:0042744)4.83305321
16negative regulation of interleukin-10 production (GO:0032693)4.56119313
17positive regulation of type 2 immune response (GO:0002830)4.47651916
18negative regulation of leukocyte apoptotic process (GO:2000107)4.31306939
19negative regulation of inclusion body assembly (GO:0090084)4.19603827
20regulation of chemokine secretion (GO:0090196)4.16476612
21mitochondrion distribution (GO:0048311)4.10359957
22intestinal epithelial cell development (GO:0060576)3.99513159
23detection of chemical stimulus (GO:0009593)3.85823996
24aromatic amino acid family catabolic process (GO:0009074)3.82185841
25chaperone mediated protein folding requiring cofactor (GO:0051085)3.78786708
26lung lobe morphogenesis (GO:0060463)3.75543758
27regulation of sensory perception of pain (GO:0051930)3.70476593
28regulation of sensory perception (GO:0051931)3.70476593
29mitochondrial calcium ion transport (GO:0006851)3.63527087
30indolalkylamine metabolic process (GO:0006586)3.55605176
31negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.47261613
32COPI coating of Golgi vesicle (GO:0048205)3.44481446
33Golgi transport vesicle coating (GO:0048200)3.44481446
34positive regulation of Rho protein signal transduction (GO:0035025)3.29127717
35wound healing, spreading of epidermal cells (GO:0035313)3.25026745
36positive regulation of pseudopodium assembly (GO:0031274)3.22919714
37amine catabolic process (GO:0009310)3.19936468
38cellular biogenic amine catabolic process (GO:0042402)3.19936468
39negative regulation of keratinocyte proliferation (GO:0010839)3.12057903
40glial cell proliferation (GO:0014009)3.10482625
41regulation of lymphocyte apoptotic process (GO:0070228)3.06972994
42mammary gland alveolus development (GO:0060749)3.04087221
43benzene-containing compound metabolic process (GO:0042537)3.03126058
44detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)24.2646049
45muscle organ morphogenesis (GO:0048644)2.88519449
46skin morphogenesis (GO:0043589)2.88241575
47protein targeting to Golgi (GO:0000042)2.85357622
48regulation of clathrin-mediated endocytosis (GO:2000369)2.84532205
49positive regulation of actin filament depolymerization (GO:0030836)2.83831436
50epithelial cell differentiation involved in prostate gland development (GO:0060742)2.81619768
51lung vasculature development (GO:0060426)2.75656149
52regulation of cytokine secretion involved in immune response (GO:0002739)2.74583091
53wound healing, spreading of cells (GO:0044319)2.73248980
54maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.72878237
55negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.71804520
56regulation of pseudopodium assembly (GO:0031272)2.70135636
57glycoprotein catabolic process (GO:0006516)2.68473532
58ovulation from ovarian follicle (GO:0001542)2.65299427
59prostate gland growth (GO:0060736)2.63691802
60establishment of endothelial barrier (GO:0061028)2.61998272
61thrombin receptor signaling pathway (GO:0070493)2.59948112
62UDP-N-acetylglucosamine metabolic process (GO:0006047)2.58026012
63activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.55280641
64localization within membrane (GO:0051668)2.55139426
65positive regulation of regulated secretory pathway (GO:1903307)2.54399198
66galactose metabolic process (GO:0006012)2.52474299
67ER overload response (GO:0006983)2.51263486
68hydrogen peroxide metabolic process (GO:0042743)2.49116756
69parturition (GO:0007567)2.47493659
70retrograde transport, vesicle recycling within Golgi (GO:0000301)2.46410999
71negative regulation of receptor-mediated endocytosis (GO:0048261)2.46384530
72establishment of protein localization to Golgi (GO:0072600)2.46048032
73aromatic amino acid family metabolic process (GO:0009072)2.44827437
74Sertoli cell development (GO:0060009)2.44603399
75protein retention in ER lumen (GO:0006621)2.39325110
76bundle of His cell to Purkinje myocyte communication (GO:0086069)2.38394347
77growth hormone receptor signaling pathway (GO:0060396)2.35409498
78regulation of superoxide anion generation (GO:0032928)2.33801480
79signal peptide processing (GO:0006465)2.32525288
80indole-containing compound metabolic process (GO:0042430)2.32225356
81keratinocyte development (GO:0003334)2.31150636
82regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.30752965
83regulation of type 2 immune response (GO:0002828)2.30026208
84response to unfolded protein (GO:0006986)2.29155005
85mammary gland epithelial cell differentiation (GO:0060644)2.26459702
86negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.23171396
87valine metabolic process (GO:0006573)2.22979684
88activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.22937320
89ethanol oxidation (GO:0006069)2.22830202
90tissue homeostasis (GO:0001894)2.22586533
91cellular copper ion homeostasis (GO:0006878)2.16260047
92negative regulation of smooth muscle cell migration (GO:0014912)2.15843316
93short-chain fatty acid metabolic process (GO:0046459)2.15681242
94branching involved in mammary gland duct morphogenesis (GO:0060444)2.15291121
95regulation of leukocyte apoptotic process (GO:2000106)2.13725138
96regulation of inclusion body assembly (GO:0090083)2.13404936
97positive regulation of nuclease activity (GO:0032075)2.13059573
98detection of chemical stimulus involved in sensory perception of taste (GO:0050912)13.9752007
99detection of chemical stimulus involved in sensory perception (GO:0050907)12.1700270
100production of molecular mediator involved in inflammatory response (GO:0002532)10.4238193

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_20079471_ChIP-ChIP_T-47D_Human5.31073629
2AR_21909140_ChIP-Seq_LNCAP_Human2.97498418
3ZNF217_24962896_ChIP-Seq_MCF-7_Human2.73716045
4FOXO3_23340844_ChIP-Seq_DLD1_Human2.73337629
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.54581433
6TP63_17297297_ChIP-ChIP_HaCaT_Human2.53013922
7ESR1_21235772_ChIP-Seq_MCF-7_Human2.43551878
8ESR2_21235772_ChIP-Seq_MCF-7_Human2.42846572
9STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.33758976
10CDX2_19796622_ChIP-Seq_MESCs_Mouse2.32702139
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.21879528
12PIAS1_25552417_ChIP-Seq_VCAP_Human2.18877488
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.18509468
14SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.15113204
15CLOCK_20551151_ChIP-Seq_293T_Human2.10142436
16FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.09816871
17ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.07864558
18SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.05779260
19TRIM28_21343339_ChIP-Seq_HEK293_Human2.05559320
20HIF1A_21447827_ChIP-Seq_MCF-7_Human2.02912878
21FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.91148192
22RXR_22158963_ChIP-Seq_LIVER_Mouse1.91058599
23STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.79046775
24FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.69513228
25ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.65369950
26LXR_22158963_ChIP-Seq_LIVER_Mouse1.64822188
27TAF15_26573619_Chip-Seq_HEK293_Human1.64235480
28EGR1_19374776_ChIP-ChIP_THP-1_Human1.61870368
29SOX2_27498859_Chip-Seq_STOMACH_Mouse1.59807018
30PPAR_26484153_Chip-Seq_NCI-H1993_Human1.51716791
31FOXM1_26456572_ChIP-Seq_MCF-7_Human1.51379445
32CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.50705220
33AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.50676851
34AHR_22903824_ChIP-Seq_MCF-7_Human1.47061657
35NRF2_20460467_ChIP-Seq_MEFs_Mouse1.40961461
36NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.40961461
37SOX2_20726797_ChIP-Seq_SW620_Human1.40744072
38ARNT_22903824_ChIP-Seq_MCF-7_Human1.40113966
39NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.39572020
40FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.37906626
41PPARA_22158963_ChIP-Seq_LIVER_Mouse1.37881257
42RXR_22108803_ChIP-Seq_LS180_Human1.36406267
43CTNNB1_20460455_ChIP-Seq_HCT116_Human1.34064124
44FOXA2_19822575_ChIP-Seq_HepG2_Human1.33987068
45TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.33984316
46ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.33679457
47RUNX1_27514584_Chip-Seq_MCF-7_Human1.33061099
48GATA3_24758297_ChIP-Seq_MCF-7_Human1.32871542
49SALL4_18804426_ChIP-ChIP_XEN_Mouse1.31651075
50AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.31486832
51GATA1_22025678_ChIP-Seq_K562_Human1.30677112
52TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.30212484
53TCF4_18268006_ChIP-ChIP_LS174T_Human1.29768799
54ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.28646936
55FUS_26573619_Chip-Seq_HEK293_Human1.24179537
56EP300_21415370_ChIP-Seq_HL-1_Mouse1.23293464
57TP53_16413492_ChIP-PET_HCT116_Human1.23136170
58WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.20017048
59FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.19952573
60OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17005611
61GATA6_25053715_ChIP-Seq_YYC3_Human1.16979345
62FOXA1_25552417_ChIP-Seq_VCAP_Human1.16430547
63KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.16396169
64SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16129112
65CJUN_26792858_Chip-Seq_BT549_Human1.12623287
66SOX9_24532713_ChIP-Seq_HFSC_Mouse1.12253052
67WT1_19549856_ChIP-ChIP_CCG9911_Human1.11566079
68AR_21572438_ChIP-Seq_LNCaP_Human1.10985515
69GATA4_25053715_ChIP-Seq_YYC3_Human1.10363823
70KLF5_20875108_ChIP-Seq_MESCs_Mouse1.09444955
71SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.09241591
72SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.09241591
73SALL1_21062744_ChIP-ChIP_HESCs_Human1.09091225
74CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.08968633
75KAP1_22055183_ChIP-Seq_ESCs_Mouse1.05717275
76LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05579038
77ZNF263_19887448_ChIP-Seq_K562_Human1.05576087
78EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.02145280
79KDM2B_26808549_Chip-Seq_REH_Human1.01509029
80RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.99577039
81RARG_19884340_ChIP-ChIP_MEFs_Mouse0.99355574
82TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.98102070
83TP63_23658742_ChIP-Seq_EP156T_Human0.94093928
84STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.93776840
85WT1_25993318_ChIP-Seq_PODOCYTE_Human0.92771319
86Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.92734103
87VDR_24787735_ChIP-Seq_THP-1_Human0.92639535
88TP53_18474530_ChIP-ChIP_U2OS_Human0.92446917
89CDX2_22108803_ChIP-Seq_LS180_Human0.92200144
90GATA2_21666600_ChIP-Seq_HMVEC_Human0.92136804
91ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.91878446
92KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.91767129
93JARID2_20075857_ChIP-Seq_MESCs_Mouse0.91223567
94ZNF274_21170338_ChIP-Seq_K562_Hela0.90296183
95SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.87361092
96TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84867437
97SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.83619228
98STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.83476714
99ZFP281_27345836_Chip-Seq_ESCs_Mouse0.83024111
100PKCTHETA_26484144_Chip-Seq_BREAST_Human0.82534339

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001346_abnormal_lacrimal_gland7.49810828
2MP0005248_abnormal_Harderian_gland5.29919159
3MP0002254_reproductive_system_inflammat4.60881570
4MP0002896_abnormal_bone_mineralization3.93589278
5MP0010030_abnormal_orbit_morphology3.37931479
6MP0002009_preneoplasia3.08174694
7MP0001533_abnormal_skeleton_physiology2.95236810
8MP0004264_abnormal_extraembryonic_tissu2.92075761
9MP0009780_abnormal_chondrocyte_physiolo2.84254074
10MP0001881_abnormal_mammary_gland2.58057569
11MP0009053_abnormal_anal_canal2.42064724
12MP0003566_abnormal_cell_adhesion2.42021256
13MP0000537_abnormal_urethra_morphology2.36656796
14MP0003300_gastrointestinal_ulcer2.22139142
15MP0005085_abnormal_gallbladder_physiolo2.18816184
16MP0009764_decreased_sensitivity_to2.03440279
17MP0000613_abnormal_salivary_gland1.97905971
18MP0010234_abnormal_vibrissa_follicle1.92930185
19MP0000627_abnormal_mammary_gland1.82155448
20MP0002006_tumorigenesis1.80795212
21MP0005390_skeleton_phenotype1.67050548
22MP0000579_abnormal_nail_morphology1.64207138
23MP0005220_abnormal_exocrine_pancreas1.58448663
24MP0002098_abnormal_vibrissa_morphology1.49714922
25MP0005623_abnormal_meninges_morphology1.47580885
26MP0002115_abnormal_skeleton_extremities1.41649718
27MP0005332_abnormal_amino_acid1.36764981
28MP0004272_abnormal_basement_membrane1.33860863
29MP0001919_abnormal_reproductive_system1.29759409
30MP0010678_abnormal_skin_adnexa1.28741998
31MP0005365_abnormal_bile_salt1.28456537
32MP0001299_abnormal_eye_distance/1.27531799
33MP0002234_abnormal_pharynx_morphology1.26797499
34MP0003315_abnormal_perineum_morphology1.26051758
35MP0001666_abnormal_nutrient_absorption1.25876872
36MP0003795_abnormal_bone_structure1.23077710
37MP0000427_abnormal_hair_cycle1.18243036
38MP0003787_abnormal_imprinting1.17181988
39MP0003690_abnormal_glial_cell1.16814431
40MP0000462_abnormal_digestive_system1.11097664
41MP0005187_abnormal_penis_morphology1.10920072
42MP0004947_skin_inflammation1.10806753
43MP0000762_abnormal_tongue_morphology1.07102589
44MP0003075_altered_response_to1.04715248
45MP0009765_abnormal_xenobiotic_induced1.04459072
46MP0005166_decreased_susceptibility_to1.03325371
47MP0001853_heart_inflammation1.01981999
48MP0000383_abnormal_hair_follicle1.00519290
49MP0009384_cardiac_valve_regurgitation1.00460024
50MP0005379_endocrine/exocrine_gland_phen1.00087815
51MP0005646_abnormal_pituitary_gland0.98376762
52MP0001340_abnormal_eyelid_morphology0.96668252
53MP0002113_abnormal_skeleton_development0.96114456
54MP0000858_altered_metastatic_potential0.95543239
55MP0000003_abnormal_adipose_tissue0.95201183
56MP0000566_synostosis0.94401655
57MP0002166_altered_tumor_susceptibility0.93952587
58MP0010352_gastrointestinal_tract_polyps0.92908801
59MP0003936_abnormal_reproductive_system0.91774149
60MP0005165_increased_susceptibility_to0.91432479
61MP0001851_eye_inflammation0.90477336
62MP0002282_abnormal_trachea_morphology0.88883062
63MP0004883_abnormal_blood_vessel0.88266346
64MP0002933_joint_inflammation0.87591805
65MP0002060_abnormal_skin_morphology0.87498312
66MP0003941_abnormal_skin_development0.87239710
67MP0002109_abnormal_limb_morphology0.80854118
68MP0003091_abnormal_cell_migration0.80725923
69MP0002796_impaired_skin_barrier0.79560114
70MP0005275_abnormal_skin_tensile0.78957840
71MP0001944_abnormal_pancreas_morphology0.78267081
72MP0000377_abnormal_hair_follicle0.76722749
73MP0004185_abnormal_adipocyte_glucose0.75767289
74MP0004270_analgesia0.74441312
75MP0004233_abnormal_muscle_weight0.72606021
76MP0001177_atelectasis0.72556603
77MP0003828_pulmonary_edema0.70952061
78MP0000747_muscle_weakness0.70841166
79MP0004019_abnormal_vitamin_homeostasis0.69964122
80MP0004130_abnormal_muscle_cell0.68062638
81MP0001765_abnormal_ion_homeostasis0.67491316
82MP0000163_abnormal_cartilage_morphology0.65606227
83MP0005360_urolithiasis0.65538879
84MP0000920_abnormal_myelination0.64998259
85MP0008438_abnormal_cutaneous_collagen0.61743577
86MP0005319_abnormal_enzyme/_coenzyme0.61502980
87MP0001216_abnormal_epidermal_layer0.58378139
88MP0003632_abnormal_nervous_system0.58037642
89MP0003045_fibrosis0.57573441
90MP0005197_abnormal_uvea_morphology0.57501961
91MP0010771_integument_phenotype0.55796300
92MP0005503_abnormal_tendon_morphology0.55697280
93MP0003123_paternal_imprinting0.55172800
94MP0003705_abnormal_hypodermis_morpholog0.54698689
95MP0005508_abnormal_skeleton_morphology0.54542495
96MP0000750_abnormal_muscle_regeneration0.53528702
97MP0005375_adipose_tissue_phenotype0.53443263
98MP0003633_abnormal_nervous_system0.53339826
99MP0010329_abnormal_lipoprotein_level0.52487181
100MP0005501_abnormal_skin_physiology0.51398245

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the phalanges of the 2nd finger (HP:0009541)4.43543932
2Fibular aplasia (HP:0002990)4.08438148
3Humeroradial synostosis (HP:0003041)3.86349069
4Synostosis involving the elbow (HP:0003938)3.86349069
5Right ventricular cardiomyopathy (HP:0011663)3.79055269
6Sensorimotor neuropathy (HP:0007141)3.68863801
7Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)3.56298234
8Short 1st metacarpal (HP:0010034)3.56298234
9Abnormality of the proximal phalanges of the hand (HP:0009834)3.52467033
10Mesomelia (HP:0003027)3.33819455
11Stomach cancer (HP:0012126)3.18432372
12Rectal prolapse (HP:0002035)3.17575327
13Abnormality of the 2nd finger (HP:0004100)3.16113447
14Hypoplastic labia majora (HP:0000059)3.15845352
15Spastic diplegia (HP:0001264)3.08202160
16Cortical dysplasia (HP:0002539)3.07529411
17Abnormality of the 1st metacarpal (HP:0010009)3.06704157
18Volvulus (HP:0002580)3.02257880
19Oligomenorrhea (HP:0000876)2.94124390
20Abnormality of the middle phalanges of the toes (HP:0010183)2.86907310
212-3 toe syndactyly (HP:0004691)2.84441917
22Short humerus (HP:0005792)2.81592334
23Hypoplastic ischia (HP:0003175)2.81398599
24Symphalangism affecting the phalanges of the hand (HP:0009773)2.80873956
25Vascular calcification (HP:0004934)2.79316394
26Cardiovascular calcification (HP:0011915)2.79073236
27Prostate neoplasm (HP:0100787)2.78784503
28Abnormality of the labia majora (HP:0012881)2.76693436
29Fibular hypoplasia (HP:0003038)2.72821664
30Premature skin wrinkling (HP:0100678)2.67800061
31Short hallux (HP:0010109)2.67493627
32Abnormality of the ischium (HP:0003174)2.65796105
33Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.61463191
34Shallow orbits (HP:0000586)2.61340388
35Increased CSF protein (HP:0002922)2.56227099
36Enlarged epiphyses (HP:0010580)2.52123477
37Short metatarsal (HP:0010743)2.50638414
38Bronchomalacia (HP:0002780)2.50594734
39Broad metatarsal (HP:0001783)2.50189614
40Abnormality of the common coagulation pathway (HP:0010990)2.49360187
41Aplasia/hypoplasia of the humerus (HP:0006507)2.48903849
42Biliary tract neoplasm (HP:0100574)2.47579744
43Aplasia/Hypoplasia of the hallux (HP:0008362)2.45921018
44Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.45875972
45Lip pit (HP:0100267)2.44231030
46Atrophic scars (HP:0001075)2.40327750
47Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.39633565
48Menorrhagia (HP:0000132)2.38560697
49Bowing of the arm (HP:0006488)2.36831384
50Bowed forearm bones (HP:0003956)2.36831384
51Submucous cleft hard palate (HP:0000176)2.36619447
52Short tibia (HP:0005736)2.34312973
53Deep venous thrombosis (HP:0002625)2.28889958
54Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.26577027
55Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.25803276
56Turricephaly (HP:0000262)2.24666934
57Aplasia/Hypoplasia of the fibula (HP:0006492)2.22679885
58Aplasia/Hypoplasia of metatarsal bones (HP:0001964)2.21282232
59Ankyloglossia (HP:0010296)2.20228983
60Gonadotropin excess (HP:0000837)2.19787278
61Abnormal pupillary function (HP:0007686)2.18297063
62Subacute progressive viral hepatitis (HP:0006572)2.17077980
63Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.16961256
64Abnormality of the phalanges of the 5th finger (HP:0004213)2.15582172
65Camptodactyly of toe (HP:0001836)2.14443613
66Aortic aneurysm (HP:0004942)2.13700127
67Absent phalangeal crease (HP:0006109)2.11402916
68Radial bowing (HP:0002986)2.09894165
69Hypoplasia of dental enamel (HP:0006297)2.05073572
70Bell-shaped thorax (HP:0001591)2.03776936
71Labial hypoplasia (HP:0000066)2.02265803
72Thoracolumbar scoliosis (HP:0002944)1.99716156
73Buphthalmos (HP:0000557)1.99537376
74Infantile muscular hypotonia (HP:0008947)1.97934848
75Abnormality of the labia minora (HP:0012880)1.96710984
76Back pain (HP:0003418)1.96234934
77Short phalanx of the thumb (HP:0009660)1.94202222
78Deformed tarsal bones (HP:0008119)1.93964400
79Milia (HP:0001056)1.93372665
80Aplasia/Hypoplasia of the tibia (HP:0005772)1.91802552
81Generalized hypopigmentation of hair (HP:0011358)1.91604518
82Alacrima (HP:0000522)1.90146037
83Narrow nasal bridge (HP:0000446)1.88349186
84Abnormality of the nasal septum (HP:0000419)1.85877658
85Abnormality of the middle phalanges of the hand (HP:0009833)1.82198445
86Coronal craniosynostosis (HP:0004440)1.79735521
87Urethral obstruction (HP:0000796)1.79236419
88Axonal loss (HP:0003447)1.78856500
89Abnormality of the intrinsic pathway (HP:0010989)1.78699052
90Macroorchidism (HP:0000053)1.78495038
91Limb-girdle muscle atrophy (HP:0003797)1.77687604
92Rhizomelia (HP:0008905)1.77600729
93Femoral bowing (HP:0002980)1.72596037
94Broad hallux (HP:0010055)1.69771731
95Micronodular cirrhosis (HP:0001413)1.69394644
96Congenital glaucoma (HP:0001087)1.67707230
97Fragile skin (HP:0001030)1.67451605
98Hypoplastic nipples (HP:0002557)1.66450091
99Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.64252419
100Ketosis (HP:0001946)1.64111921

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.96271806
2LATS14.32541541
3MAPKAPK53.69817770
4BCKDK3.32560427
5TSSK62.79381968
6EPHA32.52490809
7NEK92.38984358
8FGFR22.36817814
9FER2.35174965
10OXSR12.35113290
11EPHB12.32930865
12MAP3K22.22220013
13WNK42.22205153
14EPHA22.18399515
15PIK3CA2.16576830
16MST41.88647798
17MAP3K31.86557422
18DMPK1.78478978
19ERN11.36977810
20MET1.36970317
21PTK61.36687550
22RIPK11.34909049
23MAP2K41.28702826
24MST1R1.26232412
25TAOK31.22444749
26MAP3K41.21709541
27PDK41.16142674
28PDK31.16142674
29NUAK11.12965107
30MAP3K91.12437029
31FRK1.09583162
32HIPK21.07074002
33STK31.01990481
34LATS21.00233991
35RPS6KB21.00167506
36ERBB30.98086248
37FGFR40.94666483
38WNK10.91158200
39FGFR30.90180976
40RPS6KA40.88130514
41PDGFRB0.85685712
42JAK20.85439262
43CDK60.84727865
44RET0.84573507
45TNK20.84473413
46SIK10.82922961
47ALK0.79252264
48PDK20.78914962
49INSRR0.78432893
50PDGFRA0.78322843
51NTRK10.71606494
52FGFR10.71262505
53LMTK20.70887987
54BMX0.67427105
55BCR0.66959958
56MAP3K70.64287102
57JAK10.63704926
58TRIB30.62433512
59NTRK30.60008923
60PTK20.58442415
61IRAK10.57664269
62LRRK20.57453259
63EEF2K0.53645422
64IRAK30.52162312
65GSK3A0.51796424
66CSNK1E0.51328458
67UHMK10.50037599
68PAK30.49517860
69MINK10.46859442
70PAK20.46462202
71PLK20.45614457
72DDR20.44134187
73STK380.44060393
74ERBB20.42362839
75MTOR0.42170500
76CDK120.40335316
77MAP3K10.39135706
78MAPKAPK20.38104739
79STK38L0.36728448
80INSR0.34358237
81FYN0.33935309
82MAP2K70.32653665
83ITK0.32495401
84PRKD10.32404954
85CSK0.31610858
86SGK30.30826473
87EGFR0.29756352
88IGF1R0.28314015
89CDK50.27894104
90PRKCE0.27159913
91MAPK40.25751208
92MAPK150.22608141
93STK100.21782123
94PNCK0.21475546
95SRC0.20318335
96CAMK40.19769985
97CAMK10.19373137
98FGR0.19367097
99PDK10.18935412
100EPHA40.18927769

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009105.29334598
2African trypanosomiasis_Homo sapiens_hsa051433.81316660
3Salivary secretion_Homo sapiens_hsa049703.33365311
4Tryptophan metabolism_Homo sapiens_hsa003802.54314649
5Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.51164458
6Protein export_Homo sapiens_hsa030602.44933080
7Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.22493647
8Maturity onset diabetes of the young_Homo sapiens_hsa049501.98130150
9Primary bile acid biosynthesis_Homo sapiens_hsa001201.88744574
10Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.76821574
11Arginine biosynthesis_Homo sapiens_hsa002201.73103623
12Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.70052377
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.52350446
14Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.50316953
15Propanoate metabolism_Homo sapiens_hsa006401.44514459
16Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.34693964
17Sulfur metabolism_Homo sapiens_hsa009201.16526324
18Histidine metabolism_Homo sapiens_hsa003401.12930109
19Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.10436846
20Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.09738596
21Fatty acid degradation_Homo sapiens_hsa000711.05222184
22Estrogen signaling pathway_Homo sapiens_hsa049151.05012428
23Folate biosynthesis_Homo sapiens_hsa007901.01121766
24Thyroid hormone synthesis_Homo sapiens_hsa049181.00612293
25beta-Alanine metabolism_Homo sapiens_hsa004100.97985734
26ErbB signaling pathway_Homo sapiens_hsa040120.90690282
27Adherens junction_Homo sapiens_hsa045200.88483843
28Hippo signaling pathway_Homo sapiens_hsa043900.87203476
29Renin-angiotensin system_Homo sapiens_hsa046140.85902458
30Long-term potentiation_Homo sapiens_hsa047200.84923896
31Insulin resistance_Homo sapiens_hsa049310.82816793
32Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.82436062
33Proteoglycans in cancer_Homo sapiens_hsa052050.80667227
34Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.80141105
35Cocaine addiction_Homo sapiens_hsa050300.80020391
36Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.79051230
37Bile secretion_Homo sapiens_hsa049760.77857446
38Tight junction_Homo sapiens_hsa045300.77428142
39Amphetamine addiction_Homo sapiens_hsa050310.77395263
40Dorso-ventral axis formation_Homo sapiens_hsa043200.76924826
41Leukocyte transendothelial migration_Homo sapiens_hsa046700.76564818
42Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.73658490
43Peroxisome_Homo sapiens_hsa041460.73243813
44Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.69995615
45Gastric acid secretion_Homo sapiens_hsa049710.67997615
46Complement and coagulation cascades_Homo sapiens_hsa046100.66558918
47Renin secretion_Homo sapiens_hsa049240.66156658
48Focal adhesion_Homo sapiens_hsa045100.65317819
49Vibrio cholerae infection_Homo sapiens_hsa051100.63798219
50Pyruvate metabolism_Homo sapiens_hsa006200.63451499
51Platelet activation_Homo sapiens_hsa046110.63255615
52Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61534532
53Pancreatic secretion_Homo sapiens_hsa049720.61468253
54Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59560772
55Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.59253785
56Amoebiasis_Homo sapiens_hsa051460.58905558
57Phenylalanine metabolism_Homo sapiens_hsa003600.58599245
58Lysine degradation_Homo sapiens_hsa003100.58504733
59Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.57927425
60Butanoate metabolism_Homo sapiens_hsa006500.57502883
61Insulin secretion_Homo sapiens_hsa049110.56391632
62Bladder cancer_Homo sapiens_hsa052190.56319182
63Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.55980842
64Prolactin signaling pathway_Homo sapiens_hsa049170.54950341
65Aldosterone synthesis and secretion_Homo sapiens_hsa049250.54940437
66Type II diabetes mellitus_Homo sapiens_hsa049300.53841197
67Prion diseases_Homo sapiens_hsa050200.53035389
68Gap junction_Homo sapiens_hsa045400.52358625
69Neurotrophin signaling pathway_Homo sapiens_hsa047220.51919983
70Dilated cardiomyopathy_Homo sapiens_hsa054140.51407603
71Glucagon signaling pathway_Homo sapiens_hsa049220.50740688
72Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.50376830
73Cholinergic synapse_Homo sapiens_hsa047250.50052851
74Pancreatic cancer_Homo sapiens_hsa052120.49838410
75GnRH signaling pathway_Homo sapiens_hsa049120.49546047
762-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.48095226
77Rap1 signaling pathway_Homo sapiens_hsa040150.47964588
78Dopaminergic synapse_Homo sapiens_hsa047280.47325683
79AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.46587129
80GABAergic synapse_Homo sapiens_hsa047270.46543223
81Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46218301
82Renal cell carcinoma_Homo sapiens_hsa052110.46005336
83cAMP signaling pathway_Homo sapiens_hsa040240.45450464
84Selenocompound metabolism_Homo sapiens_hsa004500.44979171
85Prostate cancer_Homo sapiens_hsa052150.44714961
86Toxoplasmosis_Homo sapiens_hsa051450.44661930
87Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.44316611
88ECM-receptor interaction_Homo sapiens_hsa045120.44166344
89Glutamatergic synapse_Homo sapiens_hsa047240.43601071
90TGF-beta signaling pathway_Homo sapiens_hsa043500.41827465
91Glioma_Homo sapiens_hsa052140.41101859
92Circadian entrainment_Homo sapiens_hsa047130.38473899
93Hepatitis C_Homo sapiens_hsa051600.37601882
94cGMP-PKG signaling pathway_Homo sapiens_hsa040220.36843015
95Endometrial cancer_Homo sapiens_hsa052130.36506209
96Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.34674147
97Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.32367352
98Melanogenesis_Homo sapiens_hsa049160.32164521
99Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31914017
100Chemical carcinogenesis_Homo sapiens_hsa052040.31725706

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