SMR3B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glomerular filtration (GO:0003094)6.96649109
2renal filtration (GO:0097205)6.26646400
3O-glycan processing (GO:0016266)6.04606128
4digestive system process (GO:0022600)5.99122706
5biomineral tissue development (GO:0031214)5.89377817
6endothelial cell chemotaxis (GO:0035767)5.70048201
7one-carbon compound transport (GO:0019755)5.35982750
8secretion by tissue (GO:0032941)4.79652917
9regulation of bone mineralization (GO:0030500)4.75932716
10positive regulation of respiratory burst (GO:0060267)4.66031111
11tissue homeostasis (GO:0001894)4.62266104
12negative regulation of ossification (GO:0030279)4.54613072
13complement activation, classical pathway (GO:0006958)4.44726178
14regulation of biomineral tissue development (GO:0070167)4.44256286
15polyol transport (GO:0015791)4.42003559
16body fluid secretion (GO:0007589)4.15126137
17cellular response to vascular endothelial growth factor stimulus (GO:0035924)4.04294333
18complement activation (GO:0006956)3.94014158
19peptide cross-linking (GO:0018149)3.93164384
20extracellular matrix assembly (GO:0085029)3.87472770
21protein O-linked glycosylation (GO:0006493)3.85353719
22negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)3.83097016
23keratan sulfate catabolic process (GO:0042340)3.79102668
24detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)3.75526014
25negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.74637977
26extracellular fibril organization (GO:0043206)3.57050182
27regulation of chemokine-mediated signaling pathway (GO:0070099)3.44130952
28positive regulation of chemokine secretion (GO:0090197)3.37331684
29ossification (GO:0001503)3.26660678
30transepithelial transport (GO:0070633)3.25341716
31angiotensin maturation (GO:0002003)3.12517172
32fibril organization (GO:0097435)3.10752728
33protein activation cascade (GO:0072376)3.09672718
34complement activation, alternative pathway (GO:0006957)3.09273448
35toxin metabolic process (GO:0009404)3.07987940
36vascular endothelial growth factor signaling pathway (GO:0038084)3.06109139
37detection of chemical stimulus involved in sensory perception of taste (GO:0050912)3.05890395
38renal absorption (GO:0070293)3.05852371
39negative regulation of cardiac muscle hypertrophy (GO:0010614)3.04803845
40peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.03342292
41neuron projection extension involved in neuron projection guidance (GO:1902284)3.00689987
42axon extension involved in axon guidance (GO:0048846)3.00689987
43metanephric mesenchyme development (GO:0072075)2.97291434
44endothelium development (GO:0003158)2.92159583
45negative regulation of smooth muscle cell proliferation (GO:0048662)2.88949323
46regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)2.87925982
47cell proliferation involved in kidney development (GO:0072111)2.85410719
48cell proliferation involved in metanephros development (GO:0072203)2.84376177
49cell migration involved in sprouting angiogenesis (GO:0002042)2.82842486
50metanephric nephron tubule development (GO:0072234)2.78391272
51metanephric tubule development (GO:0072170)2.78391272
52negative regulation of cardiac muscle tissue growth (GO:0055022)2.77757308
53negative regulation of heart growth (GO:0061117)2.77757308
54regulation of chemokine secretion (GO:0090196)2.76265606
55negative regulation of muscle hypertrophy (GO:0014741)2.72386489
56endocrine hormone secretion (GO:0060986)2.71231767
57negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.70298008
58cell differentiation involved in metanephros development (GO:0072202)2.68828224
59cellular response to fluid shear stress (GO:0071498)2.66846086
60positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.64823285
61regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.64823285
62positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.64077768
63defense response to Gram-negative bacterium (GO:0050829)2.62615626
64negative regulation of interleukin-8 production (GO:0032717)2.61690518
65regulation of respiratory burst (GO:0060263)2.60772802
66metanephric nephron epithelium development (GO:0072243)2.60245315
67leukocyte migration involved in inflammatory response (GO:0002523)2.54875349
68fibroblast migration (GO:0010761)2.54807669
69defense response to fungus (GO:0050832)2.53515520
70kidney mesenchyme development (GO:0072074)2.50944815
71regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.49610950
72positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.49610950
73negative regulation of smooth muscle cell migration (GO:0014912)2.48208070
74regulation of cardiac muscle cell differentiation (GO:2000725)2.47865413
75hydrogen peroxide catabolic process (GO:0042744)2.46017240
76glomerular visceral epithelial cell development (GO:0072015)2.44620594
77angiogenesis involved in wound healing (GO:0060055)2.40353656
78positive regulation of T cell mediated cytotoxicity (GO:0001916)2.40195040
79regulation of dendritic cell antigen processing and presentation (GO:0002604)2.37180136
80keratinocyte differentiation (GO:0030216)2.35933087
81metanephric epithelium development (GO:0072207)2.35688847
82anatomical structure homeostasis (GO:0060249)2.33455276
83response to vitamin A (GO:0033189)2.33290192
84negative regulation of leukocyte migration (GO:0002686)2.31942038
85positive regulation of odontogenesis (GO:0042482)2.31236776
86regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.31107266
87negative regulation of adherens junction organization (GO:1903392)2.31080666
88negative regulation of focal adhesion assembly (GO:0051895)2.31080666
89negative regulation of cell junction assembly (GO:1901889)2.31080666
90ethanol oxidation (GO:0006069)2.29264717
91nephron epithelium development (GO:0072009)2.28977512
92regulation of ossification (GO:0030278)2.27814218
93regulation of membrane protein ectodomain proteolysis (GO:0051043)2.27096858
94negative regulation of glycoprotein biosynthetic process (GO:0010561)2.26609946
95response to progesterone (GO:0032570)2.26056569
96negative regulation of complement activation (GO:0045916)2.25109165
97positive regulation of monocyte chemotaxis (GO:0090026)2.24882480
98negative regulation of bone mineralization (GO:0030502)16.0094085
99retina homeostasis (GO:0001895)14.9422376
100negative regulation of biomineral tissue development (GO:0070168)14.3370017

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.18622685
2TP63_17297297_ChIP-ChIP_HaCaT_Human2.97407536
3RARG_19884340_ChIP-ChIP_MEFs_Mouse2.48981053
4NFIB_24661679_ChIP-Seq_LUNG_Mouse2.41751353
5GATA2_21666600_ChIP-Seq_HMVEC_Human2.32671544
6TRIM28_21343339_ChIP-Seq_HEK293_Human2.27499304
7STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.26620890
8ESR1_21235772_ChIP-Seq_MCF-7_Human2.06417267
9SMAD_19615063_ChIP-ChIP_OVARY_Human1.86771904
10CLOCK_20551151_ChIP-Seq_293T_Human1.75968816
11* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.74521502
12THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.72903219
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.70726134
14ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.68404145
15TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.66167566
16TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.65564829
17ESR1_20079471_ChIP-ChIP_T-47D_Human1.62417963
18PPAR_26484153_Chip-Seq_NCI-H1993_Human1.53953654
19KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.53704715
20KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.53704715
21KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.53704715
22ESR2_21235772_ChIP-Seq_MCF-7_Human1.51219137
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.51034723
24ZNF217_24962896_ChIP-Seq_MCF-7_Human1.42806086
25CJUN_26792858_Chip-Seq_BT549_Human1.40261529
26Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.38612783
27RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.38480890
28EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.37992415
29JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.37921036
30TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.35766579
31JARID2_20075857_ChIP-Seq_MESCs_Mouse1.28820913
32IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.27541781
33NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.26612213
34MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.23927414
35SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.23816389
36AHR_22903824_ChIP-Seq_MCF-7_Human1.22543418
37EED_16625203_ChIP-ChIP_MESCs_Mouse1.21690862
38SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.19298701
39SOX9_24532713_ChIP-Seq_HFSC_Mouse1.17896921
40RUNX1_27514584_Chip-Seq_MCF-7_Human1.17595282
41CDX2_19796622_ChIP-Seq_MESCs_Mouse1.14807998
42ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.14513101
43FOXO3_23340844_ChIP-Seq_DLD1_Human1.14327633
44TBX20_22328084_ChIP-Seq_HEART_Mouse1.14124460
45TBX20_22080862_ChIP-Seq_HEART_Mouse1.14124460
46ARNT_22903824_ChIP-Seq_MCF-7_Human1.13697266
47SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.12502935
48CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.11728099
49FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.10975999
50FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.09815845
51ERA_21632823_ChIP-Seq_H3396_Human1.09732137
52KDM2B_26808549_Chip-Seq_SUP-B15_Human1.07960749
53DROSHA_22980978_ChIP-Seq_HELA_Human1.05041563
54EZH2_27304074_Chip-Seq_ESCs_Mouse1.04703318
55ZNF263_19887448_ChIP-Seq_K562_Human1.01525250
56MTF2_20144788_ChIP-Seq_MESCs_Mouse1.01457882
57EZH2_18974828_ChIP-Seq_MESCs_Mouse1.01205700
58RNF2_18974828_ChIP-Seq_MESCs_Mouse1.01205700
59SOX2_20726797_ChIP-Seq_SW620_Human1.00977187
60PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.98538926
61LXR_22158963_ChIP-Seq_LIVER_Mouse0.98323094
62CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.98173207
63FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97780913
64RUNX_20019798_ChIP-Seq_JUKART_Human0.97328420
65SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.97110519
66RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.97057166
67PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.96467071
68P63_26484246_Chip-Seq_KERATINOCYTES_Human0.96360486
69PIAS1_25552417_ChIP-Seq_VCAP_Human0.96078958
70SUZ12_27294783_Chip-Seq_ESCs_Mouse0.96064179
71RNF2_27304074_Chip-Seq_ESCs_Mouse0.92650009
72GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.92090116
73SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.91895197
74BCAT_22108803_ChIP-Seq_LS180_Human0.90287272
75WT1_25993318_ChIP-Seq_PODOCYTE_Human0.89815695
76PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.89659288
77DNAJC2_21179169_ChIP-ChIP_NT2_Human0.88950344
78PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.88817097
79FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.88787833
80GATA4_25053715_ChIP-Seq_YYC3_Human0.88217902
81ERG_20517297_ChIP-Seq_VCAP_Human0.87798019
82TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.87610103
83TP53_20018659_ChIP-ChIP_R1E_Mouse0.85646118
84RXR_22158963_ChIP-Seq_LIVER_Mouse0.85266787
85TCF4_18268006_ChIP-ChIP_LS174T_Human0.84541063
86FOXM1_26456572_ChIP-Seq_MCF-7_Human0.84417184
87EP300_21415370_ChIP-Seq_HL-1_Mouse0.84184253
88GBX2_23144817_ChIP-Seq_PC3_Human0.82355066
89PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.82273230
90LXR_22292898_ChIP-Seq_THP-1_Human0.81582751
91IRF8_22096565_ChIP-ChIP_GC-B_Human0.81160852
92SMC4_20622854_ChIP-Seq_HELA_Human0.81114378
93PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.80553435
94EZH2_27294783_Chip-Seq_ESCs_Mouse0.78756834
95WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.78647622
96TBL1_22424771_ChIP-Seq_293T_Human0.77368011
97ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.77015834
98HTT_18923047_ChIP-ChIP_STHdh_Human0.75171816
99SPI1_20517297_ChIP-Seq_HL60_Human0.74652417
100BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.72607349

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005275_abnormal_skin_tensile6.77356319
2MP0010234_abnormal_vibrissa_follicle5.71144286
3MP0003724_increased_susceptibility_to5.07819437
4MP0005503_abnormal_tendon_morphology4.42711647
5MP0005670_abnormal_white_adipose3.59980657
6MP0002009_preneoplasia2.73174648
7MP0008438_abnormal_cutaneous_collagen2.69272335
8MP0002166_altered_tumor_susceptibility2.64082558
9MP0002796_impaired_skin_barrier2.41897959
10MP0003828_pulmonary_edema2.21001171
11MP0004043_abnormal_pH_regulation2.19585961
12MP0002933_joint_inflammation2.17142779
13MP0001851_eye_inflammation2.15042376
14MP0003436_decreased_susceptibility_to1.99352973
15MP0001533_abnormal_skeleton_physiology1.98297098
16MP0010368_abnormal_lymphatic_system1.94077447
17MP0003303_peritoneal_inflammation1.88678253
18MP0002108_abnormal_muscle_morphology1.81848478
19MP0000751_myopathy1.78353973
20MP0005666_abnormal_adipose_tissue1.73256009
21MP0001879_abnormal_lymphatic_vessel1.67129645
22MP0000467_abnormal_esophagus_morphology1.63113117
23MP0002006_tumorigenesis1.61803714
24MP0001958_emphysema1.61350723
25MP0002060_abnormal_skin_morphology1.58178502
26MP0005423_abnormal_somatic_nervous1.57667846
27MP0001542_abnormal_bone_strength1.55583785
28MP0003566_abnormal_cell_adhesion1.50441144
29MP0006138_congestive_heart_failure1.48462906
30MP0005647_abnormal_sex_gland1.36846377
31MP0005023_abnormal_wound_healing1.35262983
32MP0005390_skeleton_phenotype1.34340871
33MP0003279_aneurysm1.33504840
34MP0005167_abnormal_blood-brain_barrier1.31334440
35MP0010352_gastrointestinal_tract_polyps1.26637752
36MP0000465_gastrointestinal_hemorrhage1.26041564
37MP0000762_abnormal_tongue_morphology1.24128233
38MP0002249_abnormal_larynx_morphology1.20527813
39MP0009115_abnormal_fat_cell1.20317522
40MP0005164_abnormal_response_to1.17930981
41MP0004858_abnormal_nervous_system1.14258659
42MP0000678_abnormal_parathyroid_gland1.14199924
43MP0000767_abnormal_smooth_muscle1.11082633
44MP0001853_heart_inflammation1.10693843
45MP0002295_abnormal_pulmonary_circulatio1.10249067
46MP0001661_extended_life_span1.08218305
47MP0002971_abnormal_brown_adipose1.07564216
48MP0003075_altered_response_to1.07249152
49MP0000681_abnormal_thyroid_gland1.05677220
50MP0002127_abnormal_cardiovascular_syste1.04961970
51MP0004883_abnormal_blood_vessel1.04299626
52MP0000249_abnormal_blood_vessel1.04259236
53MP0009780_abnormal_chondrocyte_physiolo1.00804617
54MP0005508_abnormal_skeleton_morphology0.99564711
55MP0004036_abnormal_muscle_relaxation0.97944715
56MP0005375_adipose_tissue_phenotype0.97389216
57MP0003638_abnormal_response/metabolism_0.97192516
58MP0010386_abnormal_urinary_bladder0.95090279
59MP0004272_abnormal_basement_membrane0.90753948
60MP0002133_abnormal_respiratory_system0.89436613
61MP0005388_respiratory_system_phenotype0.89436613
62MP0004084_abnormal_cardiac_muscle0.89218879
63MP0003045_fibrosis0.87584586
64MP0010678_abnormal_skin_adnexa0.84780628
65MP0000685_abnormal_immune_system0.82698801
66MP0005397_hematopoietic_system_phenotyp0.82497952
67MP0001545_abnormal_hematopoietic_system0.82497952
68MP0000470_abnormal_stomach_morphology0.81882752
69MP0005409_darkened_coat_color0.81479884
70MP0005248_abnormal_Harderian_gland0.77752743
71MP0004264_abnormal_extraembryonic_tissu0.77539523
72MP0000049_abnormal_middle_ear0.76880196
73MP0005330_cardiomyopathy0.76414202
74MP0000759_abnormal_skeletal_muscle0.76193694
75MP0005595_abnormal_vascular_smooth0.75851967
76MP0004087_abnormal_muscle_fiber0.75540273
77MP0009278_abnormal_bone_marrow0.75287393
78MP0005369_muscle_phenotype0.74478477
79MP0003690_abnormal_glial_cell0.72196189
80MP0008789_abnormal_olfactory_epithelium0.70799061
81MP0001243_abnormal_dermal_layer0.70150888
82MP0000343_altered_response_to0.69273367
83MP0001756_abnormal_urination0.68719691
84MP0005501_abnormal_skin_physiology0.68607685
85MP0008004_abnormal_stomach_pH0.65732790
86MP0004484_altered_response_of0.64674996
87MP0000613_abnormal_salivary_gland0.64537318
88MP0005387_immune_system_phenotype0.63414717
89MP0001790_abnormal_immune_system0.63414717
90MP0004130_abnormal_muscle_cell0.63340811
91MP0003091_abnormal_cell_migration0.63321844
92MP0002128_abnormal_blood_circulation0.60833184
93MP0004145_abnormal_muscle_electrophysio0.59644077
94MP0000230_abnormal_systemic_arterial0.59038843
95MP0003938_abnormal_ear_development0.58979398
96MP0001348_abnormal_lacrimal_gland0.58327470
97MP0001984_abnormal_olfaction0.57887584
98MP0005166_decreased_susceptibility_to0.57637196
99MP0000750_abnormal_muscle_regeneration0.54966950
100MP0010771_integument_phenotype0.54890430

Predicted human phenotypes

RankGene SetZ-score
1Complement deficiency (HP:0004431)6.52434472
2Ulnar claw (HP:0001178)6.40219454
3Abnormality of complement system (HP:0005339)5.71025386
4Oral leukoplakia (HP:0002745)5.68901904
5Increased IgE level (HP:0003212)5.15223027
6Systemic lupus erythematosus (HP:0002725)4.68100666
7Type 1 muscle fiber predominance (HP:0003803)4.64882867
8Aortic aneurysm (HP:0004942)4.53187814
9Muscle fiber splitting (HP:0003555)4.42516504
10Hyporeflexia of lower limbs (HP:0002600)4.22532413
11Muscle fiber inclusion bodies (HP:0100299)4.18895061
12Glomerulonephritis (HP:0000099)4.00221616
13Acanthosis nigricans (HP:0000956)3.88851342
14Nemaline bodies (HP:0003798)3.85859250
15Distal lower limb muscle weakness (HP:0009053)3.76305098
16Segmental peripheral demyelination/remyelination (HP:0003481)3.72539967
17Increased connective tissue (HP:0009025)3.70951690
18Protrusio acetabuli (HP:0003179)3.60739026
19Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.55398388
20Emphysema (HP:0002097)3.29482687
21Increased variability in muscle fiber diameter (HP:0003557)3.26879681
22Round ear (HP:0100830)3.25116824
23Obstructive sleep apnea (HP:0002870)3.23962212
24Nephritis (HP:0000123)3.12941928
25Pulmonary artery stenosis (HP:0004415)3.01369807
26Vascular tortuosity (HP:0004948)2.94663010
27Abnormality of skeletal muscle fiber size (HP:0012084)2.91405900
28Distal arthrogryposis (HP:0005684)2.81168733
29Insidious onset (HP:0003587)2.80504173
30Termporal pattern (HP:0011008)2.80504173
31Abnormal pupillary function (HP:0007686)2.80473087
32Upper limb muscle weakness (HP:0003484)2.79002301
33Peripheral hypomyelination (HP:0007182)2.78366377
34Right ventricular cardiomyopathy (HP:0011663)2.64145203
35Foot dorsiflexor weakness (HP:0009027)2.62706290
36Lymphangioma (HP:0100764)2.58319211
37Action tremor (HP:0002345)2.54167377
38Increased CSF protein (HP:0002922)2.48204403
39Hypoplasia of the iris (HP:0007676)2.48110750
40Spinal rigidity (HP:0003306)2.47635027
41Exercise-induced myalgia (HP:0003738)2.43894900
42Abnormality of the foot musculature (HP:0001436)2.43734136
43Hematochezia (HP:0002573)2.42800322
44Mesangial abnormality (HP:0001966)2.41204157
45Hyperkalemia (HP:0002153)2.36927249
46Steppage gait (HP:0003376)2.33884867
47Oligomenorrhea (HP:0000876)2.29725732
48Aortic dissection (HP:0002647)2.28839365
49Hyperactive renin-angiotensin system (HP:0000841)2.27497778
50Hip contracture (HP:0003273)2.24975960
51Broad metatarsal (HP:0001783)2.21781563
52EMG: neuropathic changes (HP:0003445)2.21654304
53Sparse scalp hair (HP:0002209)2.19249472
54Areflexia of lower limbs (HP:0002522)2.18447057
55Mildly elevated creatine phosphokinase (HP:0008180)2.18197482
56Shallow orbits (HP:0000586)2.16791361
57Difficulty running (HP:0009046)2.14099628
58Spontaneous hematomas (HP:0007420)2.13146394
59Abnormality of the ischium (HP:0003174)2.12469451
60Amyloidosis (HP:0011034)2.12139335
61Ulnar deviation of the wrist (HP:0003049)2.09661942
62Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.09468644
63Bone cyst (HP:0012062)2.07497448
64Neck muscle weakness (HP:0000467)2.07482311
65Dilatation of the ascending aorta (HP:0005111)2.07181386
66Vertebral compression fractures (HP:0002953)2.06575796
67Aneurysm (HP:0002617)2.05449288
68Keratoconjunctivitis sicca (HP:0001097)2.05247303
69Erythroderma (HP:0001019)2.03124603
70Asymmetry of the thorax (HP:0001555)1.99077394
71Wormian bones (HP:0002645)1.97866376
72Keratoconjunctivitis (HP:0001096)1.93291023
73Cerebral aneurysm (HP:0004944)1.93121315
74Joint hemorrhage (HP:0005261)1.86896182
75Bronchomalacia (HP:0002780)1.86653736
76Villous atrophy (HP:0011473)1.85697535
77Abnormality of small intestinal villus morphology (HP:0011472)1.85697535
78Slender build (HP:0001533)1.85677542
79Lip pit (HP:0100267)1.84035850
80Arterial tortuosity (HP:0005116)1.82349786
81Abnormality of the nasal mucosa (HP:0000433)1.79133109
82Calcaneovalgus deformity (HP:0001848)1.79068229
83Enlarged penis (HP:0000040)1.78633399
84Myopathic facies (HP:0002058)1.77337270
85Visceral angiomatosis (HP:0100761)1.76998072
86Growth hormone excess (HP:0000845)1.75423520
87Hypoplastic ischia (HP:0003175)1.72462131
88Hypercortisolism (HP:0001578)1.71109459
89Alopecia of scalp (HP:0002293)1.70544158
90Gingivitis (HP:0000230)1.69786793
91Tracheomalacia (HP:0002779)1.68266413
92EMG: myopathic abnormalities (HP:0003458)1.67718552
93Limited hip movement (HP:0008800)1.67442752
94Neoplasm of the heart (HP:0100544)1.66752283
95Rectal prolapse (HP:0002035)1.66750425
96Decreased motor nerve conduction velocity (HP:0003431)1.66063426
97Hemangiomatosis (HP:0007461)1.64373178
98Prolonged bleeding time (HP:0003010)1.63003570
99Bulbar palsy (HP:0001283)1.62207437
100Abnormality of the salivary glands (HP:0010286)1.62119591

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPKAPK34.24315145
2OBSCN3.91769115
3ERN13.68917344
4MAP4K23.53988064
5MAPK152.70757598
6PIK3CA2.67452687
7RIPK12.46714257
8FRK2.43195224
9TRPM72.42253551
10DDR22.23052699
11EPHA22.19877673
12DMPK1.89600253
13BLK1.81016078
14TGFBR21.80718126
15TIE11.79356937
16EPHA31.76370529
17EPHB11.60463122
18WNK11.60092982
19MAPK71.59594958
20MST41.51436812
21STK31.51131661
22FER1.47167100
23MYLK1.45422209
24FGFR21.44136829
25TRIB31.42381559
26FGFR31.40287536
27RPS6KB21.31954123
28KIT1.28314505
29PIK3CG1.25679911
30ERBB31.23360901
31PDGFRA1.13270346
32MAP3K61.09782409
33LRRK21.09780288
34HIPK21.07489316
35NLK1.07030705
36EPHB21.06310440
37TTN1.02833233
38CSK1.00887806
39MAP2K20.98849075
40MAPKAPK20.96424359
41CDC42BPA0.96323202
42STK390.93386476
43MAPK120.91363299
44FES0.89267981
45TYK20.88937723
46MAPK40.85127127
47PAK20.84895338
48NTRK30.84221205
49MAP3K30.84045467
50EEF2K0.80814704
51DYRK1B0.80754607
52ADRBK10.79270032
53PRKD10.77309754
54SIK10.74552758
55JAK10.73275579
56MARK20.72586008
57RPS6KA20.72471034
58PRKG10.70933009
59MAP3K70.70098716
60MAP3K20.70004143
61PRKAA20.69882493
62TESK10.69078557
63PDGFRB0.67866074
64FGFR40.65913187
65TBK10.65074393
66SGK20.62588955
67PTK2B0.61490988
68CSNK2A20.61047866
69STK380.61047452
70ROCK10.60902171
71MAPK30.59063568
72PHKG10.55553614
73PHKG20.55553614
74ZAP700.55355624
75MAPK10.53850601
76MAP4K10.52446005
77MAP3K10.52367269
78SGK2230.52265456
79SGK4940.52265456
80RET0.51084854
81RPS6KA10.49656914
82SGK30.49516753
83RPS6KL10.47592662
84RPS6KC10.47592662
85JAK20.47388665
86STK40.47056340
87ROCK20.45958174
88CDK120.42911053
89ICK0.42049406
90MTOR0.41671881
91JAK30.40914764
92PKN20.40026481
93RPS6KA60.39044188
94OXSR10.38800548
95HCK0.38657603
96LCK0.37775974
97PDK20.33873312
98LYN0.32579169
99PTK20.32285954
100CAMK10.32150099

Predicted pathways (KEGG)

RankGene SetZ-score
1Salivary secretion_Homo sapiens_hsa049707.03533322
2Staphylococcus aureus infection_Homo sapiens_hsa051502.79562009
3Malaria_Homo sapiens_hsa051442.52669404
4Complement and coagulation cascades_Homo sapiens_hsa046102.23071938
5Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.16993419
6Renin-angiotensin system_Homo sapiens_hsa046141.94497696
7Renin secretion_Homo sapiens_hsa049241.62594788
8Phenylalanine metabolism_Homo sapiens_hsa003601.50488893
9ECM-receptor interaction_Homo sapiens_hsa045121.49782539
10Amoebiasis_Homo sapiens_hsa051461.42010193
11Pertussis_Homo sapiens_hsa051331.38019814
12Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.33495246
13Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.33190360
14Intestinal immune network for IgA production_Homo sapiens_hsa046721.31666597
15Vascular smooth muscle contraction_Homo sapiens_hsa042701.26408979
16Tyrosine metabolism_Homo sapiens_hsa003501.23975362
17TNF signaling pathway_Homo sapiens_hsa046681.22952479
18Osteoclast differentiation_Homo sapiens_hsa043801.18645438
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.17716833
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.16437893
21African trypanosomiasis_Homo sapiens_hsa051431.12677415
22Focal adhesion_Homo sapiens_hsa045101.12194666
23Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.11884445
24AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.07679396
25Leishmaniasis_Homo sapiens_hsa051401.06547145
26PPAR signaling pathway_Homo sapiens_hsa033201.04563965
27cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02961770
28Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.01761366
29Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.00942193
30Pancreatic secretion_Homo sapiens_hsa049720.99716412
31Prion diseases_Homo sapiens_hsa050200.99477346
32Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.97484042
33Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.97263521
34Chemokine signaling pathway_Homo sapiens_hsa040620.97240168
35Estrogen signaling pathway_Homo sapiens_hsa049150.96087598
36Allograft rejection_Homo sapiens_hsa053300.95778176
37Autoimmune thyroid disease_Homo sapiens_hsa053200.92246369
38Graft-versus-host disease_Homo sapiens_hsa053320.91950833
39Rheumatoid arthritis_Homo sapiens_hsa053230.90386926
40ABC transporters_Homo sapiens_hsa020100.90109645
41Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.89428171
42Asthma_Homo sapiens_hsa053100.88146282
43Histidine metabolism_Homo sapiens_hsa003400.88034493
44Dilated cardiomyopathy_Homo sapiens_hsa054140.85937400
45Fatty acid biosynthesis_Homo sapiens_hsa000610.81334320
46Toxoplasmosis_Homo sapiens_hsa051450.80706598
47Type I diabetes mellitus_Homo sapiens_hsa049400.79191281
48Bile secretion_Homo sapiens_hsa049760.78114474
49Dorso-ventral axis formation_Homo sapiens_hsa043200.76120148
50Jak-STAT signaling pathway_Homo sapiens_hsa046300.75373791
51Notch signaling pathway_Homo sapiens_hsa043300.74002433
52Cocaine addiction_Homo sapiens_hsa050300.73151774
53Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.69925022
54Leukocyte transendothelial migration_Homo sapiens_hsa046700.67487108
55Cyanoamino acid metabolism_Homo sapiens_hsa004600.66593843
56Insulin resistance_Homo sapiens_hsa049310.64817252
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.63812463
58GnRH signaling pathway_Homo sapiens_hsa049120.63707529
59Influenza A_Homo sapiens_hsa051640.63437920
60Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.62922585
61Ovarian steroidogenesis_Homo sapiens_hsa049130.61866660
62Phagosome_Homo sapiens_hsa041450.61685192
63Other glycan degradation_Homo sapiens_hsa005110.61099041
64Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60810939
65Viral myocarditis_Homo sapiens_hsa054160.60484482
66Amphetamine addiction_Homo sapiens_hsa050310.59714146
67Adipocytokine signaling pathway_Homo sapiens_hsa049200.59411609
68Insulin secretion_Homo sapiens_hsa049110.58577186
69Gastric acid secretion_Homo sapiens_hsa049710.57392010
70Acute myeloid leukemia_Homo sapiens_hsa052210.57270873
71Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.55316980
72Platelet activation_Homo sapiens_hsa046110.54863882
73Prostate cancer_Homo sapiens_hsa052150.54761877
74Phospholipase D signaling pathway_Homo sapiens_hsa040720.54353034
75Hematopoietic cell lineage_Homo sapiens_hsa046400.53708496
76PI3K-Akt signaling pathway_Homo sapiens_hsa041510.53276999
77Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.51951520
78Nitrogen metabolism_Homo sapiens_hsa009100.51169574
79cAMP signaling pathway_Homo sapiens_hsa040240.49157078
80Tuberculosis_Homo sapiens_hsa051520.49121806
81Arachidonic acid metabolism_Homo sapiens_hsa005900.48388072
82Adherens junction_Homo sapiens_hsa045200.48094806
83Thyroid hormone synthesis_Homo sapiens_hsa049180.47871631
84Rap1 signaling pathway_Homo sapiens_hsa040150.46182925
85Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.45593318
86Melanoma_Homo sapiens_hsa052180.45384726
87Chemical carcinogenesis_Homo sapiens_hsa052040.45151501
88Endocytosis_Homo sapiens_hsa041440.44189419
89Antigen processing and presentation_Homo sapiens_hsa046120.43993874
90Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43785893
91MAPK signaling pathway_Homo sapiens_hsa040100.43335229
92Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.42120148
93Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.41816736
94Protein digestion and absorption_Homo sapiens_hsa049740.41321436
95Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41131893
96Circadian entrainment_Homo sapiens_hsa047130.40370923
97AMPK signaling pathway_Homo sapiens_hsa041520.40216070
98NF-kappa B signaling pathway_Homo sapiens_hsa040640.40166681
99Tight junction_Homo sapiens_hsa045300.39395599
100Proteoglycans in cancer_Homo sapiens_hsa052050.39361373

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