SMS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein belonging to the spermidine/spermin synthase family. Pseudogenes of this gene are located on chromosomes 1, 5, 6 and X. Mutations in this gene are associated with X-linked Snyder-Robinson mental retardation syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of integrated proviral latency (GO:0075713)5.45178797
2establishment of viral latency (GO:0019043)4.55178673
3nuclear pore complex assembly (GO:0051292)4.29366410
4mitotic metaphase plate congression (GO:0007080)4.14603043
5negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.76573899
6negative regulation of ligase activity (GO:0051352)3.76573899
7protein complex localization (GO:0031503)3.70363454
8peptidyl-arginine omega-N-methylation (GO:0035247)3.66798601
9IMP metabolic process (GO:0046040)3.66307670
10peptidyl-arginine N-methylation (GO:0035246)3.60491495
11peptidyl-arginine methylation (GO:0018216)3.60491495
12nucleobase-containing small molecule interconversion (GO:0015949)3.56237449
13protein localization to kinetochore (GO:0034501)3.52666392
14protein maturation by protein folding (GO:0022417)3.49416644
15pore complex assembly (GO:0046931)3.49406061
16non-recombinational repair (GO:0000726)3.45353414
17double-strand break repair via nonhomologous end joining (GO:0006303)3.45353414
18DNA replication checkpoint (GO:0000076)3.45140124
19metaphase plate congression (GO:0051310)3.43919773
20histone arginine methylation (GO:0034969)3.42069864
21DNA ligation (GO:0006266)3.41883045
22L-serine metabolic process (GO:0006563)3.38882556
23purine nucleobase biosynthetic process (GO:0009113)3.31302240
24ribosome biogenesis (GO:0042254)3.29525935
25ribosome assembly (GO:0042255)3.29523035
26formation of translation preinitiation complex (GO:0001731)3.28298403
27regulation of mitotic spindle organization (GO:0060236)3.24900763
28nucleobase biosynthetic process (GO:0046112)3.22108005
29maturation of SSU-rRNA (GO:0030490)3.20797043
30mitotic recombination (GO:0006312)3.19827730
31spliceosomal snRNP assembly (GO:0000387)3.18889159
32telomere maintenance via recombination (GO:0000722)3.16622092
33regulation of ubiquitin-protein transferase activity (GO:0051438)3.14865328
34pre-miRNA processing (GO:0031054)3.08614658
35cellular protein complex localization (GO:0034629)3.08377390
36establishment of chromosome localization (GO:0051303)3.08257195
37CENP-A containing nucleosome assembly (GO:0034080)3.04932396
38protein localization to chromosome, centromeric region (GO:0071459)3.04706907
39DNA replication-independent nucleosome organization (GO:0034724)3.04498093
40DNA replication-independent nucleosome assembly (GO:0006336)3.04498093
41regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.04092566
42heterochromatin organization (GO:0070828)3.03791116
43regulation of cellular amino acid metabolic process (GO:0006521)3.03461347
44de novo protein folding (GO:0006458)3.02049842
45DNA replication initiation (GO:0006270)3.01693238
46regulation of ligase activity (GO:0051340)3.01341785
47ventricular cardiac muscle cell development (GO:0055015)2.98079765
48mitotic sister chromatid segregation (GO:0000070)2.97676770
49mitotic nuclear envelope disassembly (GO:0007077)2.97448669
50DNA strand elongation involved in DNA replication (GO:0006271)2.97207416
51positive regulation of ligase activity (GO:0051351)2.97172883
52ribonucleoprotein complex biogenesis (GO:0022613)2.95705527
53maturation of 5.8S rRNA (GO:0000460)2.95559141
54chromatin remodeling at centromere (GO:0031055)2.95052536
55G1/S transition of mitotic cell cycle (GO:0000082)2.94514975
56cell cycle G1/S phase transition (GO:0044843)2.94514975
57establishment of protein localization to mitochondrial membrane (GO:0090151)2.93740831
58spindle checkpoint (GO:0031577)2.92116674
59kinetochore assembly (GO:0051382)2.90930420
60signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.90684703
61signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.90684703
62signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.90684703
63signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.90343061
64intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.90343061
65tRNA aminoacylation for protein translation (GO:0006418)2.90158406
66signal transduction involved in DNA damage checkpoint (GO:0072422)2.88800883
67signal transduction involved in DNA integrity checkpoint (GO:0072401)2.88800883
68membrane disassembly (GO:0030397)2.88637742
69nuclear envelope disassembly (GO:0051081)2.88637742
70chromosome segregation (GO:0007059)2.88003081
71spliceosomal complex assembly (GO:0000245)2.87960343
72kinetochore organization (GO:0051383)2.87702268
73DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.87072610
74folic acid-containing compound biosynthetic process (GO:0009396)2.86884070
75histone exchange (GO:0043486)2.85300199
76DNA double-strand break processing (GO:0000729)2.85168442
77signal transduction involved in cell cycle checkpoint (GO:0072395)2.85084421
78anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.85059111
79negative regulation of chromosome segregation (GO:0051985)2.84492773
80negative regulation of mitotic sister chromatid separation (GO:2000816)2.84065857
81negative regulation of mitotic sister chromatid segregation (GO:0033048)2.84065857
82negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.84065857
83negative regulation of sister chromatid segregation (GO:0033046)2.84065857
84mitotic spindle assembly checkpoint (GO:0007094)2.82743522
85de novo posttranslational protein folding (GO:0051084)2.82536753
86mitotic spindle checkpoint (GO:0071174)2.82310199
87ATP-dependent chromatin remodeling (GO:0043044)2.81336776
88DNA damage response, detection of DNA damage (GO:0042769)2.81213231
89spindle assembly checkpoint (GO:0071173)2.81176884
90ribosomal large subunit biogenesis (GO:0042273)2.80989425
91DNA strand elongation (GO:0022616)2.80644468
92rRNA processing (GO:0006364)2.79404170
93negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.79105440
94DNA replication-dependent nucleosome assembly (GO:0006335)2.76229458
95DNA replication-dependent nucleosome organization (GO:0034723)2.76229458
96regulation of spindle organization (GO:0090224)2.75492576
97rRNA modification (GO:0000154)2.75464281
98DNA unwinding involved in DNA replication (GO:0006268)2.74265807
99regulation of mitotic metaphase/anaphase transition (GO:0030071)2.72980472
100rRNA metabolic process (GO:0016072)2.71949108
101regulation of chromosome segregation (GO:0051983)2.71154448
102regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.71092203
103sister chromatid segregation (GO:0000819)2.71091547
1047-methylguanosine mRNA capping (GO:0006370)2.70321402
105attachment of spindle microtubules to kinetochore (GO:0008608)2.70081721
106regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.69399364
107telomere maintenance via semi-conservative replication (GO:0032201)2.68889352
108negative regulation of microtubule polymerization (GO:0031115)2.68680465
109positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.68388066
110transcription elongation from RNA polymerase III promoter (GO:0006385)2.67635933
111termination of RNA polymerase III transcription (GO:0006386)2.67635933
112regulation of translational termination (GO:0006449)2.67559001
113regulation of mitotic sister chromatid separation (GO:0010965)2.67369447
114regulation of mitotic sister chromatid segregation (GO:0033047)2.67369447
115regulation of sister chromatid segregation (GO:0033045)2.67369447
116regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.67087011
1177-methylguanosine RNA capping (GO:0009452)2.66616839
118RNA capping (GO:0036260)2.66616839
119histone H2A acetylation (GO:0043968)2.66057842
120negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.61642776
121translational initiation (GO:0006413)2.61242885
122microtubule depolymerization (GO:0007019)2.61061053
123viral mRNA export from host cell nucleus (GO:0046784)2.60648127
124nuclear pore organization (GO:0006999)2.60048563
125regulation of short-term neuronal synaptic plasticity (GO:0048172)2.58528089
126transcription elongation from RNA polymerase I promoter (GO:0006362)2.58509272
127cullin deneddylation (GO:0010388)2.58184750
128mitotic chromosome condensation (GO:0007076)2.57516923
129regulation of centrosome cycle (GO:0046605)2.56531647
130maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.56350224
131mitotic sister chromatid cohesion (GO:0007064)2.55337840
132RNA splicing, via transesterification reactions (GO:0000375)2.54499871
133RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.54358788
134mRNA splicing, via spliceosome (GO:0000398)2.54358788
135positive regulation of chromosome segregation (GO:0051984)2.53955054
136regulation of double-strand break repair via homologous recombination (GO:0010569)2.53685710
137protein deneddylation (GO:0000338)2.51741675
138protein localization to chromosome (GO:0034502)2.51561597
139regulation of nuclear cell cycle DNA replication (GO:0033262)2.51180440
140proteasome assembly (GO:0043248)2.50373189
141IMP biosynthetic process (GO:0006188)2.49830118
142positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.49605314

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.25515736
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.16452110
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.97808200
4* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.54024550
5MYC_19079543_ChIP-ChIP_MESCs_Mouse3.19649367
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.16409879
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.97209142
8ETS1_20019798_ChIP-Seq_JURKAT_Human2.93701588
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.87244962
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.71338201
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.68794508
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.68462864
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.65115371
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.63977438
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.58975677
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.57386826
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.54714680
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.50076502
19KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.34462332
20XRN2_22483619_ChIP-Seq_HELA_Human2.32261748
21THAP11_20581084_ChIP-Seq_MESCs_Mouse2.15622864
22VDR_23849224_ChIP-Seq_CD4+_Human2.10675963
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.05983933
24YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.01792423
25NELFA_20434984_ChIP-Seq_ESCs_Mouse2.00552049
26TTF2_22483619_ChIP-Seq_HELA_Human1.98623991
27POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.97241060
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.96729506
29TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.93349935
30EZH2_22144423_ChIP-Seq_EOC_Human1.92456621
31MYCN_18555785_ChIP-Seq_MESCs_Mouse1.92434946
32RBPJ_22232070_ChIP-Seq_NCS_Mouse1.92365365
33* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.89831003
34E2F1_21310950_ChIP-Seq_MCF-7_Human1.86508679
35SALL1_21062744_ChIP-ChIP_HESCs_Human1.82947613
36MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.80562518
37GABP_19822575_ChIP-Seq_HepG2_Human1.77891499
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.77459723
39CIITA_25753668_ChIP-Seq_RAJI_Human1.77444548
40AR_21909140_ChIP-Seq_LNCAP_Human1.71711352
41FOXP3_21729870_ChIP-Seq_TREG_Human1.71066673
42YY1_21170310_ChIP-Seq_MESCs_Mouse1.65946728
43MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.64742861
44DCP1A_22483619_ChIP-Seq_HELA_Human1.62760400
45SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.60194400
46ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.57983904
47* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.56444800
48* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.53439638
49TP63_19390658_ChIP-ChIP_HaCaT_Human1.50812599
50NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.44954556
51KDM5A_27292631_Chip-Seq_BREAST_Human1.42704750
52ZFX_18555785_ChIP-Seq_MESCs_Mouse1.40363606
53CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.39840864
54ELK1_19687146_ChIP-ChIP_HELA_Human1.38746982
55CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.38337941
56FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.34949242
57SOX17_20123909_ChIP-Seq_XEN_Mouse1.34904122
58ELF1_17652178_ChIP-ChIP_JURKAT_Human1.34828467
59HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.34698623
60EGR1_19374776_ChIP-ChIP_THP-1_Human1.33690453
61CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.31131458
62TFEB_21752829_ChIP-Seq_HELA_Human1.31102482
63SRF_21415370_ChIP-Seq_HL-1_Mouse1.29868234
64PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.28998783
65NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.26365457
66* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.24720512
67CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.22770124
68MYC_22102868_ChIP-Seq_BL_Human1.21293382
69ERG_20887958_ChIP-Seq_HPC-7_Mouse1.19572588
70ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.18047897
71SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.16308055
72NANOG_16153702_ChIP-ChIP_HESCs_Human1.15333172
73STAT3_1855785_ChIP-Seq_MESCs_Mouse1.14100611
74DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.13993284
75* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.13991744
76CLOCK_20551151_ChIP-Seq_293T_Human1.13979127
77SOX2_18555785_ChIP-Seq_MESCs_Mouse1.13904361
78SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.13656688
79SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.13347219
80PADI4_21655091_ChIP-ChIP_MCF-7_Human1.12775365
81MYC_18940864_ChIP-ChIP_HL60_Human1.12707864
82POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.11833474
83* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.09585303
84KLF4_18555785_ChIP-Seq_MESCs_Mouse1.09383761
85SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.07674713
86HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.06549043
87* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.03755702
88DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.03501747
89* NANOG_21062744_ChIP-ChIP_HESCs_Human1.02466292
90EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.02228989
91* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.01651728
92CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.00866179
93CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.99743386
94E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97692631
95* NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.97278703
96* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.96607746
97HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.96150856
98HOXB4_20404135_ChIP-ChIP_EML_Mouse0.95495835
99TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.94248492
100CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.92782859
101REST_21632747_ChIP-Seq_MESCs_Mouse0.92562498
102CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.91422932
103CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.91325166
104ELK1_22589737_ChIP-Seq_MCF10A_Human0.91058761
105SOX2_16153702_ChIP-ChIP_HESCs_Human0.90859834
106TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.90347393
107TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.88064382
108KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.87894951
109KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.87894951
110KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.87894951
111ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.87862823
112NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.87363768
113ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.86283468
114ZNF263_19887448_ChIP-Seq_K562_Human0.85901153
115ZNF274_21170338_ChIP-Seq_K562_Hela0.85644272
116SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.85494426
117REST_18959480_ChIP-ChIP_MESCs_Mouse0.85226454
118FUS_26573619_Chip-Seq_HEK293_Human0.84584221
119SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.84309294
120ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.83544967
121ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.83488450
122EWS_26573619_Chip-Seq_HEK293_Human0.81372613
123POU5F1_16153702_ChIP-ChIP_HESCs_Human0.80533178
124RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.80399578
125BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.77663022
126* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.77631271
127NOTCH1_21737748_ChIP-Seq_TLL_Human0.76525666
128SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.75412939

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.91445339
2MP0004859_abnormal_synaptic_plasticity3.20953398
3MP0003111_abnormal_nucleus_morphology3.16702647
4MP0010094_abnormal_chromosome_stability3.08029251
5MP0003941_abnormal_skin_development3.00139238
6MP0004957_abnormal_blastocyst_morpholog2.97272365
7MP0002877_abnormal_melanocyte_morpholog2.92887051
8MP0003123_paternal_imprinting2.75884307
9MP0003077_abnormal_cell_cycle2.71690843
10MP0003880_abnormal_central_pattern2.42238524
11MP0008057_abnormal_DNA_replication2.34983804
12MP0009697_abnormal_copulation2.32087647
13MP0008058_abnormal_DNA_repair2.18726600
14MP0010352_gastrointestinal_tract_polyps2.13561950
15MP0008877_abnormal_DNA_methylation2.10787292
16MP0005257_abnormal_intraocular_pressure2.07899993
17MP0003635_abnormal_synaptic_transmissio2.06070631
18MP0003186_abnormal_redox_activity1.98405587
19MP0006292_abnormal_olfactory_placode1.95985185
20MP0005423_abnormal_somatic_nervous1.95232279
21MP0003121_genomic_imprinting1.89877882
22MP0008932_abnormal_embryonic_tissue1.86671710
23MP0003806_abnormal_nucleotide_metabolis1.84651067
24MP0001293_anophthalmia1.80137631
25MP0006054_spinal_hemorrhage1.75559372
26MP0002063_abnormal_learning/memory/cond1.75446014
27MP0002102_abnormal_ear_morphology1.74633414
28MP0004270_analgesia1.67815655
29MP0001730_embryonic_growth_arrest1.65788703
30MP0003646_muscle_fatigue1.63402140
31MP0002090_abnormal_vision1.61694392
32MP0008007_abnormal_cellular_replicative1.59712487
33MP0006276_abnormal_autonomic_nervous1.56395474
34MP0000358_abnormal_cell_content/1.56393732
35MP0001529_abnormal_vocalization1.55958237
36MP0000350_abnormal_cell_proliferation1.55881344
37MP0002734_abnormal_mechanical_nocicepti1.54078141
38MP0004272_abnormal_basement_membrane1.51180321
39MP0003787_abnormal_imprinting1.49567563
40MP0003890_abnormal_embryonic-extraembry1.48588511
41MP0005394_taste/olfaction_phenotype1.47653469
42MP0005499_abnormal_olfactory_system1.47653469
43MP0009745_abnormal_behavioral_response1.47037704
44MP0002184_abnormal_innervation1.46572683
45MP0003950_abnormal_plasma_membrane1.45470101
46MP0002697_abnormal_eye_size1.44275320
47MP0009046_muscle_twitch1.44014508
48MP0001968_abnormal_touch/_nociception1.43272252
49MP0003315_abnormal_perineum_morphology1.41711742
50MP0002254_reproductive_system_inflammat1.38685812
51MP0010234_abnormal_vibrissa_follicle1.38217827
52MP0004145_abnormal_muscle_electrophysio1.37705305
53MP0002572_abnormal_emotion/affect_behav1.35948114
54MP0005408_hypopigmentation1.34987999
55MP0003122_maternal_imprinting1.34244687
56MP0002653_abnormal_ependyma_morphology1.32748169
57MP0002938_white_spotting1.31235605
58MP0003718_maternal_effect1.31219423
59MP0001849_ear_inflammation1.31061650
60MP0008789_abnormal_olfactory_epithelium1.30762918
61MP0000778_abnormal_nervous_system1.29009747
62MP0003937_abnormal_limbs/digits/tail_de1.28347465
63MP0002064_seizures1.25770911
64MP0003786_premature_aging1.25236637
65MP0001697_abnormal_embryo_size1.24960468
66MP0004811_abnormal_neuron_physiology1.24499833
67MP0000372_irregular_coat_pigmentation1.24473114
68MP0003566_abnormal_cell_adhesion1.23945974
69MP0001727_abnormal_embryo_implantation1.22742962
70MP0005380_embryogenesis_phenotype1.18709683
71MP0001672_abnormal_embryogenesis/_devel1.18709683
72MP0001440_abnormal_grooming_behavior1.17811191
73MP0002735_abnormal_chemical_nociception1.17404660
74MP0005248_abnormal_Harderian_gland1.17192777
75MP0002638_abnormal_pupillary_reflex1.17119366
76MP0002084_abnormal_developmental_patter1.15911141
77MP0001299_abnormal_eye_distance/1.15700638
78MP0005197_abnormal_uvea_morphology1.15242533
79MP0002085_abnormal_embryonic_tissue1.14866363
80MP0002092_abnormal_eye_morphology1.14774173
81MP0001188_hyperpigmentation1.14237583
82MP0002733_abnormal_thermal_nociception1.13707444
83MP0003861_abnormal_nervous_system1.11547978
84MP0000647_abnormal_sebaceous_gland1.10835068
85MP0005623_abnormal_meninges_morphology1.10366098
86MP0003119_abnormal_digestive_system1.09670430
87MP0000569_abnormal_digit_pigmentation1.09344082
88MP0002067_abnormal_sensory_capabilities1.09173721
89MP0002751_abnormal_autonomic_nervous1.08788023
90MP0003136_yellow_coat_color1.08337171
91MP0003221_abnormal_cardiomyocyte_apopto1.06908760
92MP0001486_abnormal_startle_reflex1.06850199
93MP0002080_prenatal_lethality1.06390401
94MP0001970_abnormal_pain_threshold1.05912943
95MP0010307_abnormal_tumor_latency1.04874377
96MP0005386_behavior/neurological_phenoty1.04827194
97MP0004924_abnormal_behavior1.04827194
98MP0002272_abnormal_nervous_system1.04447449
99MP0005058_abnormal_lysosome_morphology1.03668768
100MP0003705_abnormal_hypodermis_morpholog1.00597550
101MP0001905_abnormal_dopamine_level0.99689591
102MP0003567_abnormal_fetal_cardiomyocyte0.99513814
103MP0002736_abnormal_nociception_after0.98854208
104MP0003984_embryonic_growth_retardation0.98851422
105MP0002233_abnormal_nose_morphology0.97903346
106MP0002088_abnormal_embryonic_growth/wei0.97669934
107MP0008260_abnormal_autophagy0.96383067
108MP0004233_abnormal_muscle_weight0.96217970
109MP0005384_cellular_phenotype0.96156057
110MP0000751_myopathy0.96134845
111MP0003938_abnormal_ear_development0.95703480
112MP0002152_abnormal_brain_morphology0.94360070
113MP0002557_abnormal_social/conspecific_i0.94041698
114MP0002111_abnormal_tail_morphology0.91557052
115MP0000490_abnormal_crypts_of0.91239616
116MP0000955_abnormal_spinal_cord0.90542397
117MP0002822_catalepsy0.89508172
118MP0002396_abnormal_hematopoietic_system0.89047842
119MP0000537_abnormal_urethra_morphology0.87678224
120MP0006072_abnormal_retinal_apoptosis0.87641642
121MP0001853_heart_inflammation0.85738509
122MP0009703_decreased_birth_body0.85575407
123MP0005451_abnormal_body_composition0.85366108
124MP0000313_abnormal_cell_death0.85169120
125MP0003453_abnormal_keratinocyte_physiol0.85129393
126MP0001286_abnormal_eye_development0.84956714
127MP0002882_abnormal_neuron_morphology0.84748596
128MP0001915_intracranial_hemorrhage0.84428059
129MP0005193_abnormal_anterior_eye0.81803121
130MP0001501_abnormal_sleep_pattern0.79834238
131MP0002210_abnormal_sex_determination0.79731883
132MP0010030_abnormal_orbit_morphology0.79144689
133MP0000750_abnormal_muscle_regeneration0.78843175
134MP0005621_abnormal_cell_physiology0.78765823
135MP0006036_abnormal_mitochondrial_physio0.78413836
136MP0005501_abnormal_skin_physiology0.78177864
137MP0002066_abnormal_motor_capabilities/c0.77870012
138MP0000631_abnormal_neuroendocrine_gland0.76789804
139MP0009672_abnormal_birth_weight0.76252547
140MP0003879_abnormal_hair_cell0.75902954
141MP0006035_abnormal_mitochondrial_morpho0.75762602
142MP0004215_abnormal_myocardial_fiber0.75454285
143MP0005187_abnormal_penis_morphology0.75055026
144MP0001881_abnormal_mammary_gland0.74823129
145MP0002086_abnormal_extraembryonic_tissu0.73255784
146MP0001984_abnormal_olfaction0.73248009
147MP0004197_abnormal_fetal_growth/weight/0.71924835
148MP0003755_abnormal_palate_morphology0.71438495
149MP0001186_pigmentation_phenotype0.69646589
150MP0009053_abnormal_anal_canal0.68279916
151MP0000579_abnormal_nail_morphology0.66911583
152MP0000343_altered_response_to0.63927355
153MP0005171_absent_coat_pigmentation0.63729094
154MP0005391_vision/eye_phenotype0.63476952
155MP0002019_abnormal_tumor_incidence0.62490028
156MP0000432_abnormal_head_morphology0.62043544

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)3.85391365
2Abnormality of the labia minora (HP:0012880)3.74050200
3Abnormality of glycolysis (HP:0004366)3.71669758
4Cortical dysplasia (HP:0002539)3.67961790
5Multiple enchondromatosis (HP:0005701)3.63002314
6Increased serum pyruvate (HP:0003542)3.51979820
7Shoulder girdle muscle weakness (HP:0003547)3.40494539
8Focal motor seizures (HP:0011153)3.10829985
9Spastic diplegia (HP:0001264)3.06980077
10Pelvic girdle muscle weakness (HP:0003749)2.98619007
11Cerebral hypomyelination (HP:0006808)2.93093906
12Patellar aplasia (HP:0006443)2.92412468
13Aplasia/Hypoplasia of the sacrum (HP:0008517)2.82988003
14Aplasia/Hypoplasia of the patella (HP:0006498)2.80294817
15Myokymia (HP:0002411)2.78935535
16Cholecystitis (HP:0001082)2.78793605
17Abnormal gallbladder physiology (HP:0012438)2.78793605
18Abnormal lung lobation (HP:0002101)2.73393116
19Visual hallucinations (HP:0002367)2.68021460
20Nephroblastoma (Wilms tumor) (HP:0002667)2.64693215
21Abnormality of the hip-girdle musculature (HP:0001445)2.62883105
22Abnormality of the musculature of the pelvis (HP:0001469)2.62883105
23Breast hypoplasia (HP:0003187)2.57013916
24Ependymoma (HP:0002888)2.52782019
25Deviation of the thumb (HP:0009603)2.52414671
26Proximal placement of thumb (HP:0009623)2.51382457
27Embryonal renal neoplasm (HP:0011794)2.50369393
28Selective tooth agenesis (HP:0001592)2.49542141
29Atrophy/Degeneration involving motor neurons (HP:0007373)2.48123864
30Medulloblastoma (HP:0002885)2.48086529
31Progressive external ophthalmoplegia (HP:0000590)2.44296907
32Microvesicular hepatic steatosis (HP:0001414)2.40086090
33Colon cancer (HP:0003003)2.39535558
34Amyotrophic lateral sclerosis (HP:0007354)2.38429060
35Facial cleft (HP:0002006)2.35189888
36Impulsivity (HP:0100710)2.35034043
37Carpal bone hypoplasia (HP:0001498)2.31919610
38Abnormality of the anterior horn cell (HP:0006802)2.29239760
39Degeneration of anterior horn cells (HP:0002398)2.29239760
40Chromsome breakage (HP:0040012)2.26899479
41Abnormality of the umbilical cord (HP:0010881)2.24891978
42Facial hemangioma (HP:0000329)2.21902420
43Chromosomal breakage induced by crosslinking agents (HP:0003221)2.20645197
44Rough bone trabeculation (HP:0100670)2.18333226
45Meckel diverticulum (HP:0002245)2.16009023
46Acute encephalopathy (HP:0006846)2.15908434
47Focal seizures (HP:0007359)2.15544136
48Oral leukoplakia (HP:0002745)2.13739508
49Nuclear cataract (HP:0100018)2.13474300
50Acute necrotizing encephalopathy (HP:0006965)2.13286136
51Abnormality of the preputium (HP:0100587)2.13235002
52Mutism (HP:0002300)2.13045408
53Unsteady gait (HP:0002317)2.11115160
54Abnormality of methionine metabolism (HP:0010901)2.08739239
55Increased hepatocellular lipid droplets (HP:0006565)2.08488696
56Progressive cerebellar ataxia (HP:0002073)2.06586934
57Abnormality of the ileum (HP:0001549)2.06045317
58Febrile seizures (HP:0002373)2.03744520
59Fetal akinesia sequence (HP:0001989)2.03493053
60Hypoplastic pelvis (HP:0008839)2.03383209
61Abnormal mitochondria in muscle tissue (HP:0008316)2.01001119
62Progressive muscle weakness (HP:0003323)2.00631803
63Aplasia/Hypoplasia of the uvula (HP:0010293)1.99929429
64Abnormal number of incisors (HP:0011064)1.99860911
65Abnormality of chromosome stability (HP:0003220)1.99845047
66Aplastic anemia (HP:0001915)1.99498236
67Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.99324256
68Abnormality of alanine metabolism (HP:0010916)1.99324256
69Hyperalaninemia (HP:0003348)1.99324256
70Disinhibition (HP:0000734)1.98880350
71Secondary amenorrhea (HP:0000869)1.97561334
72Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.96489344
73Astrocytoma (HP:0009592)1.95866824
74Abnormality of the astrocytes (HP:0100707)1.95866824
75Horseshoe kidney (HP:0000085)1.95249219
76Aplasia/Hypoplasia of the sternum (HP:0006714)1.93578916
77Glossoptosis (HP:0000162)1.92619647
78Atonic seizures (HP:0010819)1.92168418
79Absence seizures (HP:0002121)1.91775779
80Progressive inability to walk (HP:0002505)1.91577319
81Abnormalities of placenta or umbilical cord (HP:0001194)1.90422033
82Premature rupture of membranes (HP:0001788)1.89054090
83Papilledema (HP:0001085)1.88617159
84Cleft eyelid (HP:0000625)1.88491325
85Abnormality of the duodenum (HP:0002246)1.88232768
86Type I transferrin isoform profile (HP:0003642)1.88101556
87Rimmed vacuoles (HP:0003805)1.88011681
88Abnormality of cells of the erythroid lineage (HP:0012130)1.86972580
89Abnormal umbilical cord blood vessels (HP:0011403)1.85947592
90Single umbilical artery (HP:0001195)1.85947592
91Abnormality of the fetal cardiovascular system (HP:0010948)1.85947592
92Upper limb muscle weakness (HP:0003484)1.85212550
93Rhabdomyosarcoma (HP:0002859)1.84971688
94Stenosis of the external auditory canal (HP:0000402)1.84233046
95Glioma (HP:0009733)1.83426859
96Dysphonia (HP:0001618)1.82732846
97Prominent metopic ridge (HP:0005487)1.82237387
98Poor head control (HP:0002421)1.81372329
99Increased CSF lactate (HP:0002490)1.81299516
100Overriding aorta (HP:0002623)1.80319909
101Premature ovarian failure (HP:0008209)1.80256561
102CNS hypomyelination (HP:0003429)1.80210662
103Fasciculations (HP:0002380)1.80015958
104Cerebral edema (HP:0002181)1.79824504
105Absent radius (HP:0003974)1.79440608
106Supernumerary spleens (HP:0009799)1.79038001
107Delusions (HP:0000746)1.78364117
108Sparse eyelashes (HP:0000653)1.76353966
109Volvulus (HP:0002580)1.75934688
110Insidious onset (HP:0003587)1.75466163
111Termporal pattern (HP:0011008)1.75466163
112Prominent nose (HP:0000448)1.74472290
113Neuroblastic tumors (HP:0004376)1.74040996
114Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.74040996
115Neuroblastoma (HP:0003006)1.74040996
116Primitive neuroectodermal tumor (HP:0030065)1.74040996
117Agnosia (HP:0010524)1.73567718
118Aplasia involving forearm bones (HP:0009822)1.73567135
119Absent forearm bone (HP:0003953)1.73567135
120Premature graying of hair (HP:0002216)1.72921795
121Reduced antithrombin III activity (HP:0001976)1.71583041
122Abnormal trabecular bone morphology (HP:0100671)1.71130082
123Absent thumb (HP:0009777)1.70742757
124Abnormality of the carotid arteries (HP:0005344)1.70489921
125Abnormal number of erythroid precursors (HP:0012131)1.69654627
126Limb dystonia (HP:0002451)1.67901280
127Aplasia/hypoplasia of the humerus (HP:0006507)1.67425821
128Neoplasm of the colon (HP:0100273)1.66901347
129Tetraparesis (HP:0002273)1.66679361
130Lipid accumulation in hepatocytes (HP:0006561)1.66607362
131Small intestinal stenosis (HP:0012848)1.66565078
132Duodenal stenosis (HP:0100867)1.66565078
133Myelodysplasia (HP:0002863)1.66563277
134Impaired smooth pursuit (HP:0007772)1.66462916
135Poor eye contact (HP:0000817)1.65909704
136Dialeptic seizures (HP:0011146)1.65484692
137Tracheoesophageal fistula (HP:0002575)1.65291990
138Reticulocytopenia (HP:0001896)1.63750332
139Abnormality of chromosome segregation (HP:0002916)1.63589237
140High anterior hairline (HP:0009890)1.59635783
141Exercise-induced muscle cramps (HP:0003710)1.59167529
142* Broad-based gait (HP:0002136)1.58292604
143Hypoplasia of the capital femoral epiphysis (HP:0003090)1.58290413
144Bifid tongue (HP:0010297)1.58133358
145Cafe-au-lait spot (HP:0000957)1.58039090
146Entropion (HP:0000621)1.57923457
147Increased serum lactate (HP:0002151)1.57678207
148Ventricular fibrillation (HP:0001663)1.57535361
149Pointed chin (HP:0000307)1.56684384
150Papillary thyroid carcinoma (HP:0002895)1.56522620
151Adrenal hypoplasia (HP:0000835)1.55959674
152Postnatal microcephaly (HP:0005484)1.55697856
153Intrahepatic cholestasis (HP:0001406)1.55139506
154Upper motor neuron abnormality (HP:0002127)1.54686235
155Abnormality of serum amino acid levels (HP:0003112)1.54553999
156Cellular immunodeficiency (HP:0005374)1.54483030
157Atresia of the external auditory canal (HP:0000413)1.54316391
158Increased nuchal translucency (HP:0010880)1.53747477
159Basal cell carcinoma (HP:0002671)1.53723729
160Acute lymphatic leukemia (HP:0006721)1.53709527
161Malignant neoplasm of the central nervous system (HP:0100836)1.53484107
162Personality changes (HP:0000751)1.53114187
163Drooling (HP:0002307)1.52543538
164Excessive salivation (HP:0003781)1.52543538

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE13.31793604
2BUB13.28719913
3MARK13.18251402
4PBK3.13682171
5CDC72.91624064
6NEK12.79241679
7PNCK2.54507177
8TRIM282.54155843
9SRPK12.48578280
10TSSK62.48475164
11MST42.35967894
12MAP3K92.33952214
13EIF2AK12.26125554
14VRK22.18463555
15MAP3K42.14927776
16LATS22.08274758
17NTRK32.00189242
18PLK31.87558948
19PAK41.86540763
20MINK11.85726854
21IRAK31.83644956
22PDK21.80223073
23PLK41.79446770
24NEK21.63171376
25MAP2K71.59730275
26PLK11.57644679
27BCR1.56370029
28BRSK11.54810588
29NME11.54054017
30DYRK31.52350855
31MKNK21.50160132
32TESK11.49348575
33KSR11.48237572
34ERBB41.47301183
35CCNB11.37465105
36MKNK11.36784103
37CDK191.36759046
38TTK1.36603441
39MAP3K121.33083447
40ALK1.32679835
41ACVR1B1.26790147
42CHEK21.25260141
43NTRK21.20475380
44STK161.18892348
45PAK61.16347143
46TAOK21.16253637
47MAPK131.15278802
48BRAF1.11209555
49DYRK21.10072061
50SCYL21.08512584
51AURKA1.06686389
52BRSK21.05976288
53NME21.05697933
54STK101.05254474
55TAOK11.04921361
56DAPK11.04832155
57MAP2K41.02107894
58ATR1.01237893
59PLK21.00502885
60SIK30.99360743
61VRK10.98613985
62TAF10.96759398
63TNIK0.95966338
64AURKB0.94346182
65ZAK0.93948707
66RAF10.93150668
67ARAF0.92414223
68EPHA20.91811556
69CHEK10.90959855
70EIF2AK20.89591046
71EPHA40.88551394
72KSR20.88003164
73MST1R0.87561230
74TLK10.87081064
75EIF2AK30.80665646
76AKT30.80603485
77CDK180.80469316
78MOS0.77133125
79ABL20.76808831
80CDK150.76571757
81CDK11A0.76034938
82CDK20.75915163
83PIM20.75684321
84CDK140.74614591
85TESK20.74187514
86MAP3K50.73424465
87STK380.73038104
88PHKG10.72627593
89PHKG20.72627593
90PDK30.72312033
91PDK40.72312033
92CSNK1A1L0.70910572
93MET0.69219266
94CSNK1E0.68474722
95ERBB30.66519122
96CSNK1G10.66337869
97PRKCG0.65222223
98MAP3K60.64738242
99PTK20.62018221
100CSNK1G20.60906280
101CDK10.60638114
102STK30.60118857
103PAK10.60056541
104ATM0.60026896
105DYRK1A0.59676180
106MAP3K80.59075055
107FGFR10.57719453
108CDK60.57299589
109CDK40.56693580
110RPS6KA40.56309408
111CDK70.54549012
112KDR0.53058778
113STK38L0.51979141
114UHMK10.50795142
115CSNK2A20.50554212
116CSNK1G30.49862396
117LIMK10.47537381
118GRK50.46155910
119CDK80.45485357
120ILK0.45443744
121PRKCI0.45053183
122CDK50.44407375
123TYRO30.44343763
124MAP3K110.43441446
125CLK10.42768009
126PDGFRA0.42503583
127PINK10.42099953
128STK40.41882230
129WNK30.41097234
130STK240.40652607
131SMG10.40349192
132LATS10.40094529
133AKT20.39550929
134MAPK100.38938718
135CAMKK10.38097254
136CSNK2A10.37795449
137SIK20.37571831
138MAP3K30.35662883
139DMPK0.33788136

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.22857173
2RNA polymerase_Homo sapiens_hsa030203.02398743
3DNA replication_Homo sapiens_hsa030302.97600665
4RNA transport_Homo sapiens_hsa030132.82935679
5Spliceosome_Homo sapiens_hsa030402.71271744
6Proteasome_Homo sapiens_hsa030502.62125261
7Mismatch repair_Homo sapiens_hsa034302.60332425
8Ribosome_Homo sapiens_hsa030102.29028859
9Cell cycle_Homo sapiens_hsa041102.19611661
10Oocyte meiosis_Homo sapiens_hsa041142.04509069
11Protein export_Homo sapiens_hsa030602.03746967
12Nucleotide excision repair_Homo sapiens_hsa034201.97797020
13Nicotine addiction_Homo sapiens_hsa050331.96627757
14Biosynthesis of amino acids_Homo sapiens_hsa012301.90672058
15Base excision repair_Homo sapiens_hsa034101.90484846
16mRNA surveillance pathway_Homo sapiens_hsa030151.88606927
17Homologous recombination_Homo sapiens_hsa034401.75986884
18Steroid biosynthesis_Homo sapiens_hsa001001.75818191
19Pyrimidine metabolism_Homo sapiens_hsa002401.75388448
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.70274219
21RNA degradation_Homo sapiens_hsa030181.67626548
22* Cysteine and methionine metabolism_Homo sapiens_hsa002701.65327333
23Carbon metabolism_Homo sapiens_hsa012001.62992382
24Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.62171453
25Basal transcription factors_Homo sapiens_hsa030221.60797428
26Pyruvate metabolism_Homo sapiens_hsa006201.60364304
27Synaptic vesicle cycle_Homo sapiens_hsa047211.58647897
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.56077036
29Fatty acid elongation_Homo sapiens_hsa000621.53662125
30Fanconi anemia pathway_Homo sapiens_hsa034601.45917179
31Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.45384438
32Long-term potentiation_Homo sapiens_hsa047201.43163470
33Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.41750572
34Pentose phosphate pathway_Homo sapiens_hsa000301.41234817
35Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.31291248
36Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.31140464
37Amphetamine addiction_Homo sapiens_hsa050311.16766820
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.14824047
39Epstein-Barr virus infection_Homo sapiens_hsa051691.13347260
40Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.13103932
41Purine metabolism_Homo sapiens_hsa002301.11887041
42Olfactory transduction_Homo sapiens_hsa047401.11075760
43Dopaminergic synapse_Homo sapiens_hsa047281.11067538
44Folate biosynthesis_Homo sapiens_hsa007901.09715082
45* Glutathione metabolism_Homo sapiens_hsa004801.09532327
46Galactose metabolism_Homo sapiens_hsa000521.06341908
47Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.05899661
48Vitamin B6 metabolism_Homo sapiens_hsa007501.02969195
49Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.01453318
50Huntingtons disease_Homo sapiens_hsa050160.99056365
51p53 signaling pathway_Homo sapiens_hsa041150.98639992
52Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.98283317
53Propanoate metabolism_Homo sapiens_hsa006400.97491087
54Non-homologous end-joining_Homo sapiens_hsa034500.94983091
55Circadian entrainment_Homo sapiens_hsa047130.92771949
56Selenocompound metabolism_Homo sapiens_hsa004500.91410732
57Cardiac muscle contraction_Homo sapiens_hsa042600.91357662
58Colorectal cancer_Homo sapiens_hsa052100.90469548
59mTOR signaling pathway_Homo sapiens_hsa041500.90314156
60Parkinsons disease_Homo sapiens_hsa050120.89634811
61Adherens junction_Homo sapiens_hsa045200.88793427
62Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.86838466
63Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.84704046
64GABAergic synapse_Homo sapiens_hsa047270.83835175
65Glutamatergic synapse_Homo sapiens_hsa047240.83402881
66Vibrio cholerae infection_Homo sapiens_hsa051100.82675806
67Sulfur metabolism_Homo sapiens_hsa009200.81376980
68Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.79942763
69Long-term depression_Homo sapiens_hsa047300.79103973
70Shigellosis_Homo sapiens_hsa051310.78709119
71Oxytocin signaling pathway_Homo sapiens_hsa049210.78453912
72Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.78118210
73GnRH signaling pathway_Homo sapiens_hsa049120.77784232
74Alcoholism_Homo sapiens_hsa050340.75618750
75Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.75415970
76Morphine addiction_Homo sapiens_hsa050320.74915467
77One carbon pool by folate_Homo sapiens_hsa006700.73779289
78Circadian rhythm_Homo sapiens_hsa047100.72628115
79Cholinergic synapse_Homo sapiens_hsa047250.72476229
80Gap junction_Homo sapiens_hsa045400.71676163
81Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.71481160
82Fructose and mannose metabolism_Homo sapiens_hsa000510.71407790
83Glioma_Homo sapiens_hsa052140.68885735
84Oxidative phosphorylation_Homo sapiens_hsa001900.68273787
85Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.67111239
86Bladder cancer_Homo sapiens_hsa052190.66786602
87Legionellosis_Homo sapiens_hsa051340.66115918
88Regulation of autophagy_Homo sapiens_hsa041400.65996325
89N-Glycan biosynthesis_Homo sapiens_hsa005100.65670960
90Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.65431875
91Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.64189547
92Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.63789950
93Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.62607388
94Endometrial cancer_Homo sapiens_hsa052130.61637119
95Phototransduction_Homo sapiens_hsa047440.61382337
96Serotonergic synapse_Homo sapiens_hsa047260.61106117
97Taste transduction_Homo sapiens_hsa047420.60511081
98Salmonella infection_Homo sapiens_hsa051320.60498055
99Neurotrophin signaling pathway_Homo sapiens_hsa047220.58593766
100Sulfur relay system_Homo sapiens_hsa041220.58579433
101Thyroid cancer_Homo sapiens_hsa052160.58311327
102Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.57149011
103Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56186964
104ErbB signaling pathway_Homo sapiens_hsa040120.55504414
105Estrogen signaling pathway_Homo sapiens_hsa049150.55281059
106Collecting duct acid secretion_Homo sapiens_hsa049660.54549349
107Wnt signaling pathway_Homo sapiens_hsa043100.53424632
108Non-small cell lung cancer_Homo sapiens_hsa052230.53136388
109Cocaine addiction_Homo sapiens_hsa050300.52421056
110HTLV-I infection_Homo sapiens_hsa051660.51321235
111Viral carcinogenesis_Homo sapiens_hsa052030.51271782
112Calcium signaling pathway_Homo sapiens_hsa040200.51075989
113TGF-beta signaling pathway_Homo sapiens_hsa043500.49969353
114Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.49957601
115Tight junction_Homo sapiens_hsa045300.49235082
116Alzheimers disease_Homo sapiens_hsa050100.47902100
117* Metabolic pathways_Homo sapiens_hsa011000.47845831
118Gastric acid secretion_Homo sapiens_hsa049710.47684918
119MAPK signaling pathway_Homo sapiens_hsa040100.47640070
120VEGF signaling pathway_Homo sapiens_hsa043700.46904295
121Hippo signaling pathway_Homo sapiens_hsa043900.46317395
122Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.46232837
123MicroRNAs in cancer_Homo sapiens_hsa052060.44668674
124HIF-1 signaling pathway_Homo sapiens_hsa040660.44051712
125Aldosterone synthesis and secretion_Homo sapiens_hsa049250.43002449
126Insulin secretion_Homo sapiens_hsa049110.42981827
127Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41257232
128Lysosome_Homo sapiens_hsa041420.41254974
129Salivary secretion_Homo sapiens_hsa049700.39981331
130Renal cell carcinoma_Homo sapiens_hsa052110.39252220
131Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38929298
132Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.38740512
133Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38669852
134Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.38530627
135FoxO signaling pathway_Homo sapiens_hsa040680.38311415
136Melanogenesis_Homo sapiens_hsa049160.38145196
137Insulin signaling pathway_Homo sapiens_hsa049100.37849003
138Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.37611233
139Phosphatidylinositol signaling system_Homo sapiens_hsa040700.37540966
140Herpes simplex infection_Homo sapiens_hsa051680.36008876
141Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.35734528
142Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.35176264
143Central carbon metabolism in cancer_Homo sapiens_hsa052300.34480016
144Hedgehog signaling pathway_Homo sapiens_hsa043400.33296880
145Fatty acid metabolism_Homo sapiens_hsa012120.32656528
146Basal cell carcinoma_Homo sapiens_hsa052170.30156531
147Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.29419171
148Proteoglycans in cancer_Homo sapiens_hsa052050.28279367
149Sphingolipid metabolism_Homo sapiens_hsa006000.27896799
150Small cell lung cancer_Homo sapiens_hsa052220.27330051
151Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.24205445
152* Arginine and proline metabolism_Homo sapiens_hsa003300.24187638
153Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.19265955
154Apoptosis_Homo sapiens_hsa042100.18711718
155Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.18381083
156Prion diseases_Homo sapiens_hsa050200.14889873
157Pentose and glucuronate interconversions_Homo sapiens_hsa000400.14552104
158Prostate cancer_Homo sapiens_hsa052150.13951024

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