SMTN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a structural protein that is found exclusively in contractile smooth muscle cells. It associates with stress fibers and constitutes part of the cytoskeleton. This gene is localized to chromosome 22q12.3, distal to the TUPLE1 locus and outside the DiGeorge syndrome deletion. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)5.93053994
2plasma membrane repair (GO:0001778)5.49744921
3cardiac myofibril assembly (GO:0055003)5.44920713
4actin-myosin filament sliding (GO:0033275)4.77192873
5muscle filament sliding (GO:0030049)4.77192873
6myofibril assembly (GO:0030239)4.58994685
7negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.42126156
8bundle of His cell to Purkinje myocyte communication (GO:0086069)4.37478044
9heart trabecula formation (GO:0060347)4.36792440
10cardiac muscle cell development (GO:0055013)4.33517860
11regulation of skeletal muscle contraction (GO:0014819)4.25221786
12vascular endothelial growth factor signaling pathway (GO:0038084)4.24914580
13actomyosin structure organization (GO:0031032)4.23589449
14cardiac cell development (GO:0055006)4.17053127
15epithelial cell-cell adhesion (GO:0090136)4.13766710
16actin-mediated cell contraction (GO:0070252)4.12652786
17negative regulation of potassium ion transmembrane transport (GO:1901380)3.99854390
18hemidesmosome assembly (GO:0031581)3.93586351
19cell-substrate junction assembly (GO:0007044)3.89959847
20basement membrane organization (GO:0071711)3.88954427
21protein heterotrimerization (GO:0070208)3.79450314
22cardiac muscle contraction (GO:0060048)3.56696986
23ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.55637664
24trabecula formation (GO:0060343)3.54262346
25collagen fibril organization (GO:0030199)3.51478877
26renal filtration (GO:0097205)3.51241512
27ventricular cardiac muscle cell action potential (GO:0086005)3.50715792
28cardiac muscle tissue morphogenesis (GO:0055008)3.49781082
29endothelial cell chemotaxis (GO:0035767)3.47687381
30extracellular matrix assembly (GO:0085029)3.46580564
31regulation of cardioblast differentiation (GO:0051890)3.46060660
32positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.44957528
33semaphorin-plexin signaling pathway (GO:0071526)3.43724799
34barbed-end actin filament capping (GO:0051016)3.40823521
35skin morphogenesis (GO:0043589)3.40725629
36actin filament-based movement (GO:0030048)3.40688014
37endodermal cell differentiation (GO:0035987)3.40635479
38protein localization to endosome (GO:0036010)3.40312941
39muscle tissue morphogenesis (GO:0060415)3.38969775
40regulation of tight junction assembly (GO:2000810)3.37271283
41retina vasculature morphogenesis in camera-type eye (GO:0061299)3.35669367
42desmosome organization (GO:0002934)3.34775826
43cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.31319586
44regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.31011895
45carnitine shuttle (GO:0006853)3.30712928
46tricarboxylic acid cycle (GO:0006099)3.30500502
47adherens junction assembly (GO:0034333)3.27766087
48glomerular basement membrane development (GO:0032836)3.25234900
49Golgi transport vesicle coating (GO:0048200)3.23557973
50COPI coating of Golgi vesicle (GO:0048205)3.23557973
51atrioventricular valve morphogenesis (GO:0003181)3.21419110
52cardiac muscle cell proliferation (GO:0060038)3.20601150
53cytoskeletal anchoring at plasma membrane (GO:0007016)3.19980618
54cell adhesion mediated by integrin (GO:0033627)3.17826514
55actin filament depolymerization (GO:0030042)3.16885256
56dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.16625039
57glomerular filtration (GO:0003094)3.16505229
58negative regulation of fatty acid transport (GO:2000192)3.13374044
59regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.12728378
60planar cell polarity pathway involved in neural tube closure (GO:0090179)3.12197096
61wound healing, spreading of epidermal cells (GO:0035313)3.12071497
62cell-substrate adherens junction assembly (GO:0007045)3.09120306
63focal adhesion assembly (GO:0048041)3.09120306
64regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.08154732
65chondrocyte proliferation (GO:0035988)3.07401784
66cell migration involved in sprouting angiogenesis (GO:0002042)3.05848344
67negative regulation of chondrocyte differentiation (GO:0032331)3.05602812
68stress fiber assembly (GO:0043149)3.04509289
69negative regulation of cardiac muscle tissue growth (GO:0055022)3.03968370
70negative regulation of heart growth (GO:0061117)3.03968370
71lymph vessel development (GO:0001945)3.02939774
72branching involved in salivary gland morphogenesis (GO:0060445)3.02370595
73endothelial cell morphogenesis (GO:0001886)3.00150285
74fibroblast migration (GO:0010761)2.97307451
75regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.92956908
76regulation of p38MAPK cascade (GO:1900744)2.92765905
77insulin-like growth factor receptor signaling pathway (GO:0048009)2.90905972
78regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.90890288
79regulation of actin filament-based movement (GO:1903115)2.90684656
80substrate-dependent cell migration (GO:0006929)2.89520144
81regulation of hippo signaling (GO:0035330)2.89167761
82negative regulation of cell size (GO:0045792)2.87862346
83regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.86910948
84fatty acid transmembrane transport (GO:1902001)2.83182461
85mesodermal cell differentiation (GO:0048333)2.82536811
86hippo signaling (GO:0035329)2.79986767
87apoptotic process involved in morphogenesis (GO:0060561)2.79861449
88ventricular cardiac muscle cell development (GO:0055015)2.79414003
89negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.78740226
90endothelium development (GO:0003158)2.77438966
91lymphangiogenesis (GO:0001946)2.76620040
92vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.76562380
93protein hydroxylation (GO:0018126)2.75492520
94blood vessel endothelial cell migration (GO:0043534)2.75373182
95endocardial cushion development (GO:0003197)2.74425999
96regulation of SMAD protein import into nucleus (GO:0060390)2.74257668
97adult heart development (GO:0007512)2.73782807
98peptidyl-proline hydroxylation (GO:0019511)2.72646522
99protein retention in ER lumen (GO:0006621)2.72527573
100kidney mesenchyme development (GO:0072074)2.72088733
101collagen metabolic process (GO:0032963)2.72056803
102paraxial mesoderm development (GO:0048339)2.71406899
103negative regulation of striated muscle cell apoptotic process (GO:0010664)2.70755316
104cell migration involved in heart development (GO:0060973)2.66800438
105substrate adhesion-dependent cell spreading (GO:0034446)2.66752974
106striated muscle contraction (GO:0006941)2.66542048
107extracellular fibril organization (GO:0043206)2.66246792
108regulation of relaxation of muscle (GO:1901077)2.65381244
109positive regulation of receptor recycling (GO:0001921)2.65116685
110striated muscle cell proliferation (GO:0014855)2.65067563
111positive regulation of blood vessel endothelial cell migration (GO:0043536)2.64933557
112maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.63994808
113regulation of the force of heart contraction (GO:0002026)2.62020777
114hypotonic response (GO:0006971)2.60902860
115cell junction assembly (GO:0034329)2.60531262
116collagen catabolic process (GO:0030574)2.59543644
117cell volume homeostasis (GO:0006884)2.58726174
118multicellular organismal macromolecule metabolic process (GO:0044259)2.57602133
119cardiac muscle hypertrophy (GO:0003300)2.54926829
120venous blood vessel morphogenesis (GO:0048845)2.54340597
121type B pancreatic cell proliferation (GO:0044342)2.53949063
122apoptotic cell clearance (GO:0043277)2.52723650
123heart morphogenesis (GO:0003007)2.52539516
124outflow tract septum morphogenesis (GO:0003148)2.51193958
125extracellular matrix disassembly (GO:0022617)2.50680896
126regulation of sarcomere organization (GO:0060297)2.50573544
127blood vessel maturation (GO:0001955)2.50514321
128sequestering of extracellular ligand from receptor (GO:0035581)2.49917953
129multicellular organismal metabolic process (GO:0044236)2.49879935
130regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.46001299
131multicellular organismal catabolic process (GO:0044243)2.45854402
132endocytic recycling (GO:0032456)2.44939941
133regulation of early endosome to late endosome transport (GO:2000641)2.44885473
134negative regulation of protein localization to cell surface (GO:2000009)2.44342774
135muscle cell migration (GO:0014812)2.42858323
136positive regulation of endothelial cell migration (GO:0010595)2.42846718
137bone trabecula formation (GO:0060346)2.42532012
138cellular response to vitamin (GO:0071295)2.41954565
139wound healing, spreading of cells (GO:0044319)2.41776113
140adhesion of symbiont to host cell (GO:0044650)2.41235284
141virion attachment to host cell (GO:0019062)2.41235284
142cell junction organization (GO:0034330)2.40913584
143regulation of glucose import in response to insulin stimulus (GO:2001273)2.40494068
144negative regulation of anoikis (GO:2000811)2.40086635
145extracellular matrix organization (GO:0030198)2.39080407
146adherens junction organization (GO:0034332)2.39031611
147extracellular structure organization (GO:0043062)2.38141256

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.64145102
2RARG_19884340_ChIP-ChIP_MEFs_Mouse4.31661008
3TRIM28_21343339_ChIP-Seq_HEK293_Human4.10453113
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.01437939
5CLOCK_20551151_ChIP-Seq_293T_Human3.19697943
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.93227441
7ZNF263_19887448_ChIP-Seq_K562_Human2.68959312
8TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.57365128
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.55264933
10* ELK3_25401928_ChIP-Seq_HUVEC_Human2.49844987
11EP300_21415370_ChIP-Seq_HL-1_Mouse2.44131680
12ESR2_21235772_ChIP-Seq_MCF-7_Human2.39517552
13* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.35094291
14TBX20_22080862_ChIP-Seq_HEART_Mouse2.32111727
15TBX20_22328084_ChIP-Seq_HEART_Mouse2.32111727
16TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.31666295
17PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.27694460
18HIF1A_21447827_ChIP-Seq_MCF-7_Human2.24363318
19ESR1_21235772_ChIP-Seq_MCF-7_Human2.20188607
20EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.12924964
21ESR1_20079471_ChIP-ChIP_T-47D_Human1.99103714
22KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.94010264
23* RACK7_27058665_Chip-Seq_MCF-7_Human1.91523962
24KDM2B_26808549_Chip-Seq_SUP-B15_Human1.90735947
25EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.85139469
26ATF3_27146783_Chip-Seq_COLON_Human1.83047081
27MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.82905042
28SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.70425916
29PPAR_26484153_Chip-Seq_NCI-H1993_Human1.68761943
30LXR_22292898_ChIP-Seq_THP-1_Human1.63529739
31* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.59325001
32UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.55604725
33CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.54915671
34WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.54494099
35STAT6_21828071_ChIP-Seq_BEAS2B_Human1.54449926
36SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.54044326
37SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.54044326
38SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.53448184
39P300_27058665_Chip-Seq_ZR-75-30cells_Human1.53437372
40TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.51138810
41TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50960476
42* KDM2B_26808549_Chip-Seq_DND41_Human1.50766712
43NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.50331407
44FOXM1_23109430_ChIP-Seq_U2OS_Human1.50088959
45ZFP281_18757296_ChIP-ChIP_E14_Mouse1.46420447
46* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.45963738
47* CJUN_26792858_Chip-Seq_BT549_Human1.44122868
48NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.43133274
49ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.42977325
50ERG_21242973_ChIP-ChIP_JURKAT_Human1.42335275
51GATA2_21666600_ChIP-Seq_HMVEC_Human1.41746072
52KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.38373999
53FOXO3_23340844_ChIP-Seq_DLD1_Human1.38017375
54SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.37677474
55STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.36017900
56UBF1/2_26484160_Chip-Seq_HMECs_Human1.35090014
57TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.34004249
58EGR1_19374776_ChIP-ChIP_THP-1_Human1.33655073
59KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.33432438
60RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33126932
61STAT3_1855785_ChIP-Seq_MESCs_Mouse1.32482317
62* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.29783950
63CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.28835624
64* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.27980560
65* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.27908365
66RUNX1_27514584_Chip-Seq_MCF-7_Human1.24964030
67* TP53_22127205_ChIP-Seq_IMR90_Human1.22994824
68JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.21849617
69THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.21711634
70TET1_21490601_ChIP-Seq_MESCs_Mouse1.20657319
71ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.20216747
72BRD4_25478319_ChIP-Seq_HGPS_Human1.19524778
73ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.19499073
74NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.19373402
75ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.19226079
76GATA4_21415370_ChIP-Seq_HL-1_Mouse1.17734678
77ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.17264938
78TET1_21451524_ChIP-Seq_MESCs_Mouse1.16355288
79KDM2B_26808549_Chip-Seq_K562_Human1.14735694
80SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.13299701
81POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.12795817
82NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.12031129
83CTCF_27219007_Chip-Seq_ERYTHROID_Human1.11889906
84AR_21909140_ChIP-Seq_LNCAP_Human1.11699555
85ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.11523109
86FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.11023372
87VDR_21846776_ChIP-Seq_THP-1_Human1.10042515
88CDX2_19796622_ChIP-Seq_MESCs_Mouse1.10013052
89SMC1_22415368_ChIP-Seq_MEFs_Mouse1.09927242
90NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.09910471
91* TCF7_22412390_ChIP-Seq_EML_Mouse1.09060805
92MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.08903915
93CTCF_27219007_Chip-Seq_Bcells_Human1.07948378
94TP63_22573176_ChIP-Seq_HFKS_Human1.05528547
95SMC4_20622854_ChIP-Seq_HELA_Human1.04709581
96* TP53_23651856_ChIP-Seq_MEFs_Mouse1.04164652
97MYC_22102868_ChIP-Seq_BL_Human1.04048707
98ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02780793
99HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.02591490
100DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.02461452
101DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.01015243
102JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00833721
103SALL4_18804426_ChIP-ChIP_XEN_Mouse1.00052010
104RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.99549716
105TCF3_18692474_ChIP-Seq_MEFs_Mouse0.98976707
106TP53_20018659_ChIP-ChIP_R1E_Mouse0.98196260
107KDM2B_26808549_Chip-Seq_JURKAT_Human0.98156166
108SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98141947
109WT1_19549856_ChIP-ChIP_CCG9911_Human0.97644256
110KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.97487145
111* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.97046439
112NCOR1_26117541_ChIP-Seq_K562_Human0.96925227
113ISL1_27105846_Chip-Seq_CPCs_Mouse0.96733927
114* SA1_27219007_Chip-Seq_ERYTHROID_Human0.96543792
115SMAD_19615063_ChIP-ChIP_OVARY_Human0.96052231
116RXR_22158963_ChIP-Seq_LIVER_Mouse0.95644525
117ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.94301010
118NFIB_24661679_ChIP-Seq_LUNG_Mouse0.93186587
119CREB1_26743006_Chip-Seq_LNCaP_Human0.93117003
120* SMC3_22415368_ChIP-Seq_MEFs_Mouse0.92807317

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.27852245
2MP0004084_abnormal_cardiac_muscle3.86313269
3MP0000751_myopathy3.69173143
4MP0002837_dystrophic_cardiac_calcinosis3.46253162
5MP0003705_abnormal_hypodermis_morpholog3.25625274
6MP0005275_abnormal_skin_tensile3.21124490
7MP0004272_abnormal_basement_membrane3.07034305
8MP0004036_abnormal_muscle_relaxation2.68905839
9MP0005330_cardiomyopathy2.66489423
10MP0000750_abnormal_muscle_regeneration2.65212414
11MP0003279_aneurysm2.63514500
12MP0000749_muscle_degeneration2.57192400
13MP0003566_abnormal_cell_adhesion2.52476189
14MP0004215_abnormal_myocardial_fiber2.38050251
15MP0005623_abnormal_meninges_morphology2.36122266
16MP0005503_abnormal_tendon_morphology2.33687695
17MP0010368_abnormal_lymphatic_system2.27095227
18MP0004087_abnormal_muscle_fiber2.24421914
19MP0005257_abnormal_intraocular_pressure2.18284089
20MP0003646_muscle_fatigue2.07414873
21MP0001958_emphysema2.06401769
22MP0008775_abnormal_heart_ventricle2.01326235
23MP0006054_spinal_hemorrhage2.01242419
24MP0010630_abnormal_cardiac_muscle1.99702147
25MP0005409_darkened_coat_color1.88757446
26MP0002972_abnormal_cardiac_muscle1.87235396
27MP0006138_congestive_heart_failure1.81549019
28* MP0005620_abnormal_muscle_contractility1.79279713
29MP0001544_abnormal_cardiovascular_syste1.75747013
30MP0005385_cardiovascular_system_phenoty1.75747013
31MP0001879_abnormal_lymphatic_vessel1.72779949
32MP0002877_abnormal_melanocyte_morpholog1.65633930
33MP0003828_pulmonary_edema1.62685255
34MP0002269_muscular_atrophy1.62409759
35MP0002106_abnormal_muscle_physiology1.61232304
36MP0000747_muscle_weakness1.60084719
37MP0010352_gastrointestinal_tract_polyps1.57919562
38MP0000579_abnormal_nail_morphology1.55492874
39MP0003950_abnormal_plasma_membrane1.51990402
40MP0004484_altered_response_of1.50180911
41MP0000759_abnormal_skeletal_muscle1.45158244
42MP0005369_muscle_phenotype1.44632828
43MP0004130_abnormal_muscle_cell1.41455961
44MP0000733_abnormal_muscle_development1.40373125
45MP0000767_abnormal_smooth_muscle1.40332839
46MP0002108_abnormal_muscle_morphology1.39764414
47MP0000467_abnormal_esophagus_morphology1.39371071
48MP0004858_abnormal_nervous_system1.39314542
49MP0005023_abnormal_wound_healing1.37002614
50MP0004233_abnormal_muscle_weight1.34561431
51MP0005451_abnormal_body_composition1.33110616
52MP0003453_abnormal_keratinocyte_physiol1.32186510
53MP0003137_abnormal_impulse_conducting1.28462937
54MP0005666_abnormal_adipose_tissue1.27822814
55MP0002060_abnormal_skin_morphology1.27346954
56MP0003567_abnormal_fetal_cardiomyocyte1.23830111
57MP0010030_abnormal_orbit_morphology1.23232342
58MP0004145_abnormal_muscle_electrophysio1.22535698
59MP0005670_abnormal_white_adipose1.22199775
60MP0004510_myositis1.20831250
61MP0001299_abnormal_eye_distance/1.20377015
62MP0003091_abnormal_cell_migration1.17331568
63MP0004185_abnormal_adipocyte_glucose1.17161714
64* MP0000003_abnormal_adipose_tissue1.17110505
65* MP0000013_abnormal_adipose_tissue1.13083474
66* MP0000266_abnormal_heart_morphology1.11580117
67MP0002128_abnormal_blood_circulation1.11421813
68MP0000462_abnormal_digestive_system1.11227240
69* MP0005595_abnormal_vascular_smooth1.10111677
70MP0009384_cardiac_valve_regurgitation1.08376350
71MP0003045_fibrosis1.07489545
72MP0002127_abnormal_cardiovascular_syste1.05867891
73MP0005508_abnormal_skeleton_morphology1.01158374
74MP0002925_abnormal_cardiovascular_devel1.00888112
75MP0003385_abnormal_body_wall0.99866411
76MP0004085_abnormal_heartbeat0.99244228
77MP0000534_abnormal_ureter_morphology0.98669576
78MP0005165_increased_susceptibility_to0.98351277
79MP0002254_reproductive_system_inflammat0.97569163
80MP0000343_altered_response_to0.97314035
81MP0005501_abnormal_skin_physiology0.97280089
82MP0002234_abnormal_pharynx_morphology0.96156080
83MP0000678_abnormal_parathyroid_gland0.95661367
84MP0009840_abnormal_foam_cell0.95078259
85MP0001614_abnormal_blood_vessel0.94600587
86MP0003941_abnormal_skin_development0.93702590
87* MP0005375_adipose_tissue_phenotype0.91906246
88MP0003221_abnormal_cardiomyocyte_apopto0.89646975
89MP0000537_abnormal_urethra_morphology0.88389371
90MP0002089_abnormal_postnatal_growth/wei0.85995505
91MP0002896_abnormal_bone_mineralization0.84013017
92MP0001216_abnormal_epidermal_layer0.83893643
93MP0001348_abnormal_lacrimal_gland0.82987743
94MP0002295_abnormal_pulmonary_circulatio0.82697172
95MP0009278_abnormal_bone_marrow0.82083973
96MP0002933_joint_inflammation0.81674664
97MP0003191_abnormal_cellular_cholesterol0.81026427
98MP0002249_abnormal_larynx_morphology0.78890301
99MP0005058_abnormal_lysosome_morphology0.78376444
100MP0002796_impaired_skin_barrier0.76808979
101MP0000516_abnormal_urinary_system0.76606853
102MP0005367_renal/urinary_system_phenotyp0.76606853
103MP0009780_abnormal_chondrocyte_physiolo0.75925842
104MP0001661_extended_life_span0.75439280
105MP0003115_abnormal_respiratory_system0.74695372
106MP0001849_ear_inflammation0.74662740
107MP0009053_abnormal_anal_canal0.74365153
108MP0010771_integument_phenotype0.74337073
109MP0003984_embryonic_growth_retardation0.73480960
110MP0003300_gastrointestinal_ulcer0.72213199
111MP0002088_abnormal_embryonic_growth/wei0.72162159
112MP0005360_urolithiasis0.71039241
113MP0005167_abnormal_blood-brain_barrier0.69692021
114MP0001243_abnormal_dermal_layer0.69634560
115MP0003935_abnormal_craniofacial_develop0.69451229
116MP0000163_abnormal_cartilage_morphology0.69065952
117MP0008260_abnormal_autophagy0.68682039
118MP0003942_abnormal_urinary_system0.67725185
119MP0005076_abnormal_cell_differentiation0.67163253
120MP0002332_abnormal_exercise_endurance0.66993272
121MP0001784_abnormal_fluid_regulation0.65415313
122MP0003283_abnormal_digestive_organ0.63712977
123MP0001915_intracranial_hemorrhage0.63006616
124MP0000428_abnormal_craniofacial_morphol0.62699935
125MP0001542_abnormal_bone_strength0.62513572
126MP0000249_abnormal_blood_vessel0.61431069
127MP0010234_abnormal_vibrissa_follicle0.61136209
128MP0002282_abnormal_trachea_morphology0.61118741
129MP0001756_abnormal_urination0.60811480
130MP0009250_abnormal_appendicular_skeleto0.59827765
131MP0000762_abnormal_tongue_morphology0.59793081

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber splitting (HP:0003555)5.12743311
2Increased connective tissue (HP:0009025)4.89979342
3Protrusio acetabuli (HP:0003179)4.77463488
4Sudden death (HP:0001699)4.67972764
5Right ventricular cardiomyopathy (HP:0011663)4.64558356
6Premature rupture of membranes (HP:0001788)4.64045116
7Ventricular tachycardia (HP:0004756)4.52230278
8Aortic dissection (HP:0002647)4.24301506
9Ankle contracture (HP:0006466)4.22872169
10Hyporeflexia of lower limbs (HP:0002600)4.05791591
11Aortic aneurysm (HP:0004942)4.04992818
12Type 1 muscle fiber predominance (HP:0003803)4.03250194
13Cerebral aneurysm (HP:0004944)3.92230500
14Broad metatarsal (HP:0001783)3.65508242
15Lipoatrophy (HP:0100578)3.53715949
16Abnormality of the calf musculature (HP:0001430)3.40741297
17Exercise-induced muscle cramps (HP:0003710)3.37840778
18Atrial fibrillation (HP:0005110)3.36746226
19Difficulty climbing stairs (HP:0003551)3.22097062
20Atrophic scars (HP:0001075)3.16305304
21Primary atrial arrhythmia (HP:0001692)3.14329689
22Increased variability in muscle fiber diameter (HP:0003557)3.13141024
23Supraventricular arrhythmia (HP:0005115)3.10469742
24Calf muscle hypertrophy (HP:0008981)3.05308011
25Spinal rigidity (HP:0003306)3.02917824
26Supraventricular tachycardia (HP:0004755)3.02596566
27Exercise-induced myalgia (HP:0003738)2.90381631
28Abnormality of skeletal muscle fiber size (HP:0012084)2.89102275
29Shallow orbits (HP:0000586)2.88057591
30Difficulty running (HP:0009046)2.85711440
31Wrist flexion contracture (HP:0001239)2.79768943
32EMG: myopathic abnormalities (HP:0003458)2.79042047
33Vascular tortuosity (HP:0004948)2.77133623
34Mildly elevated creatine phosphokinase (HP:0008180)2.76321766
35Subaortic stenosis (HP:0001682)2.72477478
36Abnormality of the left ventricular outflow tract (HP:0011103)2.72477478
37Fragile skin (HP:0001030)2.71224433
38Muscle hypertrophy of the lower extremities (HP:0008968)2.70461506
39Aneurysm (HP:0002617)2.70077806
40Dilated cardiomyopathy (HP:0001644)2.65897705
41Scapular winging (HP:0003691)2.65292883
42Arterial tortuosity (HP:0005116)2.59415415
43Distal lower limb muscle weakness (HP:0009053)2.56624234
44Broad face (HP:0000283)2.54349059
45Round ear (HP:0100830)2.54203474
46Myoglobinuria (HP:0002913)2.49760901
47Soft skin (HP:0000977)2.48224596
48Asymmetric septal hypertrophy (HP:0001670)2.45494675
49Bladder diverticulum (HP:0000015)2.44905001
50Facial diplegia (HP:0001349)2.42265299
51Dilatation of the ascending aorta (HP:0005111)2.40847623
52Myotonia (HP:0002486)2.39044770
53Short nail (HP:0001799)2.37464458
54Aortic regurgitation (HP:0001659)2.37331844
55Hip contracture (HP:0003273)2.35952782
56Lymphangioma (HP:0100764)2.34939258
57Syncope (HP:0001279)2.34892354
58Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.34177406
59Mitral valve prolapse (HP:0001634)2.33847483
60Ventricular arrhythmia (HP:0004308)2.32702336
61Ulnar deviation of the wrist (HP:0003049)2.32434997
62Achilles tendon contracture (HP:0001771)2.32323388
63Limb-girdle muscle atrophy (HP:0003797)2.31763482
64Natal tooth (HP:0000695)2.29159939
65Increased density of long bones (HP:0006392)2.28989737
66Palpitations (HP:0001962)2.28734566
67Cervical subluxation (HP:0003308)2.28512347
68Ulnar bowing (HP:0003031)2.27153873
69Prolonged QT interval (HP:0001657)2.27141524
70Muscle fiber inclusion bodies (HP:0100299)2.24844531
71Atrioventricular block (HP:0001678)2.24172792
72Bundle branch block (HP:0011710)2.22966122
73Vertebral compression fractures (HP:0002953)2.22470279
74Hypoplastic ischia (HP:0003175)2.21699724
75Lower limb amyotrophy (HP:0007210)2.21158603
76Obstructive sleep apnea (HP:0002870)2.18841327
77Abnormal atrioventricular conduction (HP:0005150)2.15346966
78Generalized amyotrophy (HP:0003700)2.15001749
79Hyperacusis (HP:0010780)2.13357183
80Centrally nucleated skeletal muscle fibers (HP:0003687)2.11264862
81Distal lower limb amyotrophy (HP:0008944)2.10564370
82Thin bony cortex (HP:0002753)2.10132345
83Mitral regurgitation (HP:0001653)2.08031685
84Milia (HP:0001056)2.05380096
85Abnormality of the calcaneus (HP:0008364)2.04994736
86Abnormality of the Achilles tendon (HP:0005109)2.04841661
87Genu recurvatum (HP:0002816)2.04242067
88Heart block (HP:0012722)2.01996890
89Abnormality of dentin (HP:0010299)2.01985170
90Joint laxity (HP:0001388)2.01706102
91Stridor (HP:0010307)1.99877339
92Rhabdomyolysis (HP:0003201)1.98672273
93Rectal prolapse (HP:0002035)1.98464846
94Blue sclerae (HP:0000592)1.98340336
95Abnormality of the 4th metacarpal (HP:0010012)1.96665355
96Mesangial abnormality (HP:0001966)1.95580945
97Peritonitis (HP:0002586)1.93812382
98Trismus (HP:0000211)1.93068503
99Foot dorsiflexor weakness (HP:0009027)1.92371631
100Abnormality of the foot musculature (HP:0001436)1.90947392
101Advanced eruption of teeth (HP:0006288)1.90478452
102Wormian bones (HP:0002645)1.90412077
103Short 4th metacarpal (HP:0010044)1.90265085
104Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.90265085
105Short hallux (HP:0010109)1.89129413
106Follicular hyperkeratosis (HP:0007502)1.88528790
107Abnormality of the ischium (HP:0003174)1.88153851
108Joint stiffness (HP:0001387)1.87958046
109Knee flexion contracture (HP:0006380)1.86436759
110Neonatal short-limb short stature (HP:0008921)1.86409131
111Distal arthrogryposis (HP:0005684)1.86022392
112Long toe (HP:0010511)1.85986987
113Elbow flexion contracture (HP:0002987)1.85543929
114Neck muscle weakness (HP:0000467)1.85256767
115Myopathic facies (HP:0002058)1.85035763
116Radial bowing (HP:0002986)1.84569312
117Flat acetabular roof (HP:0003180)1.83429963
118Disproportionate tall stature (HP:0001519)1.83367589
119Biconcave vertebral bodies (HP:0004586)1.82478344
120Bicuspid aortic valve (HP:0001647)1.81004662
121Ventricular fibrillation (HP:0001663)1.80776329
122Abnormality of the acetabulum (HP:0003170)1.80073350
123Osteolytic defects of the phalanges of the hand (HP:0009771)1.79943879
124Osteolytic defects of the hand bones (HP:0009699)1.79943879
125Slender build (HP:0001533)1.79525650
126Nemaline bodies (HP:0003798)1.78433838
127Alopecia of scalp (HP:0002293)1.78419848
128Aplasia/Hypoplasia of the hallux (HP:0008362)1.78265361
129Vertebral arch anomaly (HP:0008438)1.78116194
130Limb-girdle muscle weakness (HP:0003325)1.78031573
131Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.77603557
132Pulmonary artery stenosis (HP:0004415)1.77080603
133Limited hip movement (HP:0008800)1.76744075
134Hypoventilation (HP:0002791)1.75401005
135Upper limb amyotrophy (HP:0009129)1.74557077
136Distal upper limb amyotrophy (HP:0007149)1.74557077
137Overgrowth (HP:0001548)1.73875387
138Abnormality of nail color (HP:0100643)1.70180523
139Coxa vara (HP:0002812)1.68474684
140Abnormality of the distal phalanges of the toes (HP:0010182)1.66987414
141Hyperextensible skin (HP:0000974)1.65525614
142Bowed forearm bones (HP:0003956)1.65370221

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN6.31595964
2MYLK4.05655407
3TRIB33.77670129
4PKN22.96934255
5DMPK2.89146224
6TIE12.68279040
7MST1R2.25749752
8PDGFRA2.14479147
9LMTK22.01769842
10ERN12.01387394
11KDR2.01378843
12DDR21.80061445
13RIPK11.78232186
14MAP3K61.76397267
15LATS11.71355385
16MAPK151.71314451
17TGFBR21.70894563
18EPHB21.70763036
19MAPKAPK31.64553176
20NEK11.59126761
21MAP3K101.56684018
22EPHA21.56111624
23OBSCN1.52919546
24PAK21.52504139
25EEF2K1.49033321
26NTRK11.48739459
27PDK41.48570104
28PDK31.48570104
29PTK61.43724595
30PHKG21.40828175
31PHKG11.40828175
32LATS21.35108585
33PIK3CA1.34093089
34ILK1.33842870
35SIK11.31415161
36PAK41.30048774
37EPHB11.29477660
38IRAK31.29346379
39SMG11.25334072
40LRRK21.25099399
41TRPM71.21252985
42MAP3K31.14530417
43PTK21.14354153
44PDK21.11035928
45PAK31.10512856
46FER1.08359111
47STK38L1.06894336
48PTK2B1.06066089
49MOS1.05934370
50ROCK11.04282445
51MAP2K31.04185533
52AKT31.03636481
53BCKDK1.00144857
54PIK3CG1.00004250
55BMX0.99432787
56ICK0.94775752
57PRKD10.92924735
58RPS6KB20.92762393
59TGFBR10.90341376
60CDC42BPA0.88067578
61WNK40.88059358
62MTOR0.87755780
63STK100.81977981
64TESK10.81527062
65NME20.81119030
66MET0.79843894
67ERBB40.72657246
68MAP3K70.72484802
69ARAF0.72296964
70MARK20.65933094
71FLT30.65365676
72LIMK10.65328314
73STK30.64844345
74DAPK30.63693938
75ROCK20.62160638
76RPS6KL10.61885034
77RPS6KC10.61885034
78PRPF4B0.59932243
79MAP3K130.59900374
80STK240.59423481
81CAMK1D0.58996586
82PAK10.58682073
83PDGFRB0.57368039
84FGFR10.57016962
85ABL20.55318086
86PRKG20.54091403
87EPHA30.53668674
88RPS6KA60.52953096
89MAPK120.52679241
90PRKD30.52675656
91MAP3K110.50454158
92MAP3K80.50227589
93PIM20.49894927
94RPS6KA20.49750093
95CAMK2G0.49441527
96STK40.48814247
97KSR20.48421366
98CDK120.48282675
99MAPK70.47166867
100MAPKAPK20.46543920
101FGFR40.45544518
102AKT20.44742422
103TAOK20.44072182
104MUSK0.40912321
105TAOK10.40575993
106CAMK2D0.39764281
107ZAK0.39585663
108PRKAA20.39130974
109PDPK10.38413958
110MAP2K10.38033133
111RPS6KA40.37768342
112MAP3K10.37685270
113NEK90.37379827
114PRKD20.37334824
115STK380.37226541
116PRKAA10.35846222
117RET0.34750046
118MAPK40.34420289
119ZAP700.32577607
120NEK20.31318086
121MAPK110.28414161
122CAMK1G0.27772454
123GSK3A0.26428216
124BRAF0.26406511
125PAK60.25555836
126CDK60.25123262
127RPS6KA10.25066064
128DYRK1B0.24266862
129SRC0.23286893

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.91224396
2Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.80448899
3Dilated cardiomyopathy_Homo sapiens_hsa054143.70425277
4ECM-receptor interaction_Homo sapiens_hsa045123.46269496
5Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054123.27849803
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.23581199
7Focal adhesion_Homo sapiens_hsa045102.92631195
8Viral myocarditis_Homo sapiens_hsa054162.08736215
9Adherens junction_Homo sapiens_hsa045202.00379189
10Cardiac muscle contraction_Homo sapiens_hsa042601.97168020
11Proteoglycans in cancer_Homo sapiens_hsa052051.91989288
12Small cell lung cancer_Homo sapiens_hsa052221.88571459
13Amoebiasis_Homo sapiens_hsa051461.80755094
14Fatty acid degradation_Homo sapiens_hsa000711.74696139
15Protein digestion and absorption_Homo sapiens_hsa049741.68128551
16Carbon metabolism_Homo sapiens_hsa012001.66038732
17Tight junction_Homo sapiens_hsa045301.62717911
18Propanoate metabolism_Homo sapiens_hsa006401.61684055
19Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.60688872
20Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.60471974
21Glycosaminoglycan degradation_Homo sapiens_hsa005311.59961201
22Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.53592775
23AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.50502475
24Leukocyte transendothelial migration_Homo sapiens_hsa046701.50298343
25Bladder cancer_Homo sapiens_hsa052191.41636835
26Other glycan degradation_Homo sapiens_hsa005111.37623628
27Hippo signaling pathway_Homo sapiens_hsa043901.35609694
28Fatty acid metabolism_Homo sapiens_hsa012121.34400793
29Regulation of actin cytoskeleton_Homo sapiens_hsa048101.32339807
30Prion diseases_Homo sapiens_hsa050201.27593814
31Insulin resistance_Homo sapiens_hsa049311.19867584
32MicroRNAs in cancer_Homo sapiens_hsa052061.17443679
33Basal cell carcinoma_Homo sapiens_hsa052171.15868060
34PI3K-Akt signaling pathway_Homo sapiens_hsa041511.15425527
35Lysine degradation_Homo sapiens_hsa003101.12249063
36GnRH signaling pathway_Homo sapiens_hsa049121.11440814
37HIF-1 signaling pathway_Homo sapiens_hsa040661.10947163
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.10851298
39Vascular smooth muscle contraction_Homo sapiens_hsa042701.09300424
40Chronic myeloid leukemia_Homo sapiens_hsa052201.04783993
41Axon guidance_Homo sapiens_hsa043601.01540408
42TGF-beta signaling pathway_Homo sapiens_hsa043501.01120159
43Central carbon metabolism in cancer_Homo sapiens_hsa052301.00564704
44PPAR signaling pathway_Homo sapiens_hsa033200.99899586
45Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.98077780
46Notch signaling pathway_Homo sapiens_hsa043300.97976500
47AMPK signaling pathway_Homo sapiens_hsa041520.96439749
48Platelet activation_Homo sapiens_hsa046110.94384918
49Hedgehog signaling pathway_Homo sapiens_hsa043400.93626435
50Pyruvate metabolism_Homo sapiens_hsa006200.93262733
51cGMP-PKG signaling pathway_Homo sapiens_hsa040220.91692316
52Adipocytokine signaling pathway_Homo sapiens_hsa049200.90286841
53Phospholipase D signaling pathway_Homo sapiens_hsa040720.89417677
54Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.89155391
55Biosynthesis of amino acids_Homo sapiens_hsa012300.88982112
56Insulin signaling pathway_Homo sapiens_hsa049100.88179478
57Toxoplasmosis_Homo sapiens_hsa051450.85954137
58Pathways in cancer_Homo sapiens_hsa052000.84278580
59Thyroid hormone signaling pathway_Homo sapiens_hsa049190.83388367
60ErbB signaling pathway_Homo sapiens_hsa040120.82341674
61Neurotrophin signaling pathway_Homo sapiens_hsa047220.81213271
62Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76276652
63Renal cell carcinoma_Homo sapiens_hsa052110.75685501
64Rap1 signaling pathway_Homo sapiens_hsa040150.75431560
65VEGF signaling pathway_Homo sapiens_hsa043700.74069935
66Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.73834615
67Aldosterone synthesis and secretion_Homo sapiens_hsa049250.73684295
68Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.73418741
69Renin secretion_Homo sapiens_hsa049240.73096338
70Sulfur relay system_Homo sapiens_hsa041220.72519821
71Pentose phosphate pathway_Homo sapiens_hsa000300.71492446
72Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.70790709
73Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.70537919
74Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.67497957
75Glucagon signaling pathway_Homo sapiens_hsa049220.67360475
76Arginine biosynthesis_Homo sapiens_hsa002200.65965719
77HTLV-I infection_Homo sapiens_hsa051660.65156971
78Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64977234
79Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.64808388
80Endocytosis_Homo sapiens_hsa041440.64076124
81Melanoma_Homo sapiens_hsa052180.62326696
82Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.62032240
83Phenylalanine metabolism_Homo sapiens_hsa003600.61576831
84TNF signaling pathway_Homo sapiens_hsa046680.60933363
85Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60898242
86mTOR signaling pathway_Homo sapiens_hsa041500.59110467
87Pancreatic cancer_Homo sapiens_hsa052120.55002595
88Arginine and proline metabolism_Homo sapiens_hsa003300.54799191
89Non-small cell lung cancer_Homo sapiens_hsa052230.53340083
90MAPK signaling pathway_Homo sapiens_hsa040100.53276634
91Galactose metabolism_Homo sapiens_hsa000520.51589573
92Choline metabolism in cancer_Homo sapiens_hsa052310.51584118
93Shigellosis_Homo sapiens_hsa051310.50635007
94Starch and sucrose metabolism_Homo sapiens_hsa005000.50441505
95Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50046618
96Complement and coagulation cascades_Homo sapiens_hsa046100.49631619
97Inositol phosphate metabolism_Homo sapiens_hsa005620.47351546
98Circadian rhythm_Homo sapiens_hsa047100.47300067
99Endometrial cancer_Homo sapiens_hsa052130.47242295
100Calcium signaling pathway_Homo sapiens_hsa040200.46864303
101Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.45522313
102Malaria_Homo sapiens_hsa051440.45079837
103p53 signaling pathway_Homo sapiens_hsa041150.45077773
104Glioma_Homo sapiens_hsa052140.44918084
105Salmonella infection_Homo sapiens_hsa051320.44108733
106FoxO signaling pathway_Homo sapiens_hsa040680.44068710
107Prostate cancer_Homo sapiens_hsa052150.44033203
108Ras signaling pathway_Homo sapiens_hsa040140.43578474
109Oxytocin signaling pathway_Homo sapiens_hsa049210.43505344
110Gap junction_Homo sapiens_hsa045400.41344663
111Acute myeloid leukemia_Homo sapiens_hsa052210.40839675
112Estrogen signaling pathway_Homo sapiens_hsa049150.38751444
113Thyroid cancer_Homo sapiens_hsa052160.36652670
114Dorso-ventral axis formation_Homo sapiens_hsa043200.35798582
115Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.34358408
116Parkinsons disease_Homo sapiens_hsa050120.31926782
117Wnt signaling pathway_Homo sapiens_hsa043100.31124234
118Fatty acid biosynthesis_Homo sapiens_hsa000610.31077958
119Viral carcinogenesis_Homo sapiens_hsa052030.29574273
120Apoptosis_Homo sapiens_hsa042100.29458462
121Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.29186138
122Bile secretion_Homo sapiens_hsa049760.29136447
123Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.29023371
124Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28066054
125Melanogenesis_Homo sapiens_hsa049160.28036245
126Gastric acid secretion_Homo sapiens_hsa049710.27435816
127Cyanoamino acid metabolism_Homo sapiens_hsa004600.27269479
128Fructose and mannose metabolism_Homo sapiens_hsa000510.26067744
129Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.25434858

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