SMTNL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is involved in the contraction of both striated and smooth muscle. During pregnancy, the encoded protein interacts with progesterone receptor to attenuate the expression of contractile and metabolic proteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1muscle filament sliding (GO:0030049)8.99969913
2actin-myosin filament sliding (GO:0033275)8.99969913
3motile cilium assembly (GO:0044458)7.98030017
4negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)7.90316215
5negative regulation of T-helper cell differentiation (GO:0045623)7.90316215
6skeletal muscle contraction (GO:0003009)7.51965158
7regulation of skeletal muscle contraction (GO:0014819)7.15172176
8actin-mediated cell contraction (GO:0070252)7.15134792
9platelet dense granule organization (GO:0060155)6.99043636
10plasma membrane repair (GO:0001778)6.98890789
11purine-containing compound salvage (GO:0043101)6.86604255
12negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)6.79024504
13sarcoplasmic reticulum calcium ion transport (GO:0070296)6.73225762
14response to mercury ion (GO:0046689)6.65927548
15CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)6.58401693
16response to inactivity (GO:0014854)6.50248973
17regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)6.33161804
18regulation of antigen processing and presentation of peptide antigen (GO:0002583)6.20064991
19purine nucleotide salvage (GO:0032261)6.18074354
20skeletal muscle adaptation (GO:0043501)6.11376281
21cytidine deamination (GO:0009972)6.06692491
22cytidine metabolic process (GO:0046087)6.06692491
23cytidine catabolic process (GO:0006216)6.06692491
24glycogen catabolic process (GO:0005980)5.77091226
25quinone biosynthetic process (GO:1901663)5.72072219
26ubiquinone biosynthetic process (GO:0006744)5.72072219
27negative regulation of establishment of protein localization to plasma membrane (GO:0090005)5.67991135
28cardiac myofibril assembly (GO:0055003)5.61443825
29IMP metabolic process (GO:0046040)5.60862265
30carnitine shuttle (GO:0006853)5.57663569
31regulation of isotype switching to IgG isotypes (GO:0048302)5.51134771
32glucan catabolic process (GO:0009251)5.46887269
33cardiac muscle contraction (GO:0060048)5.42360165
34cytokine production involved in immune response (GO:0002367)5.37649382
35actomyosin structure organization (GO:0031032)5.36439788
36actin filament-based movement (GO:0030048)5.32617105
37pyrimidine ribonucleoside catabolic process (GO:0046133)5.27632509
38negative regulation of nitric-oxide synthase activity (GO:0051001)5.19037857
39positive regulation of chemokine biosynthetic process (GO:0045080)5.16807901
40regulation of chronic inflammatory response (GO:0002676)5.14987839
41cellular polysaccharide catabolic process (GO:0044247)5.14362766
42glucan biosynthetic process (GO:0009250)5.13312582
43glycogen biosynthetic process (GO:0005978)5.13312582
44negative regulation of alpha-beta T cell differentiation (GO:0046639)5.11539570
45muscle fiber development (GO:0048747)5.10785435
46skeletal muscle tissue development (GO:0007519)5.05653080
47skeletal muscle fiber development (GO:0048741)5.03243448
48regulation of cAMP-dependent protein kinase activity (GO:2000479)5.02300530
49ubiquinone metabolic process (GO:0006743)4.98602592
50regulation of MHC class II biosynthetic process (GO:0045346)4.87393832
51IMP biosynthetic process (GO:0006188)4.84182861
52lung morphogenesis (GO:0060425)4.84154997
53NADH metabolic process (GO:0006734)4.81946484
54regulation of actin filament-based movement (GO:1903115)4.80266524
55response to muscle activity (GO:0014850)4.78830122
56positive regulation of phosphoprotein phosphatase activity (GO:0032516)4.74764771
57rRNA transcription (GO:0009303)4.71632576
58striated muscle adaptation (GO:0014888)4.69620043
59negative regulation of nitric oxide biosynthetic process (GO:0045019)4.69577750
60fatty acid transmembrane transport (GO:1902001)4.65425088
61polysaccharide catabolic process (GO:0000272)4.63273959
62positive regulation of myotube differentiation (GO:0010831)4.61441534
63negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.58174196
64cardiac muscle hypertrophy (GO:0003300)4.55725231
65negative regulation of potassium ion transmembrane transport (GO:1901380)4.54994387
66myotube cell development (GO:0014904)4.48635898
67axonemal dynein complex assembly (GO:0070286)4.47599487
68negative regulation of acute inflammatory response (GO:0002674)4.41314072
69muscle cell cellular homeostasis (GO:0046716)4.40629375
70striated muscle hypertrophy (GO:0014897)4.34807522
71fructose metabolic process (GO:0006000)4.33494940
72regulation of proton transport (GO:0010155)4.30902099
73T cell lineage commitment (GO:0002360)4.28960922
74glycogen metabolic process (GO:0005977)4.13364996
752-oxoglutarate metabolic process (GO:0006103)4.13215752
76regulation of interleukin-13 production (GO:0032656)4.12053748
77muscle organ development (GO:0007517)4.11567944
78muscle structure development (GO:0061061)4.11445799
79positive regulation of mitochondrial calcium ion concentration (GO:0051561)4.11058597
80cortical actin cytoskeleton organization (GO:0030866)4.08714715
81striated muscle contraction (GO:0006941)4.06973757
82glucan metabolic process (GO:0044042)4.06529181
83cellular glucan metabolic process (GO:0006073)4.06529181
84regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.05182296
85muscle cell fate commitment (GO:0042693)4.01941633
86sphingomyelin metabolic process (GO:0006684)3.99647070
87positive regulation of filopodium assembly (GO:0051491)3.98421147
88carnitine transmembrane transport (GO:1902603)3.96915922
89mRNA cleavage (GO:0006379)3.96802432
90negative regulation of protein localization to plasma membrane (GO:1903077)3.96306575
91negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.93971849
92muscle hypertrophy (GO:0014896)3.91050188
93striated muscle cell development (GO:0055002)3.89489193
94regulation of striated muscle contraction (GO:0006942)3.89032522
95regulation of chemokine biosynthetic process (GO:0045073)3.88358255
96defense response to protozoan (GO:0042832)3.87028213
97creatine metabolic process (GO:0006600)3.86832622
98gluconeogenesis (GO:0006094)3.84374352
99muscle tissue morphogenesis (GO:0060415)3.81587867
100muscle adaptation (GO:0043500)3.81577819
101myoblast fusion (GO:0007520)3.77013259
102positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.76957786
103muscle contraction (GO:0006936)3.75556391
104sarcomere organization (GO:0045214)3.72793245
105regulation of calcium ion transmembrane transport (GO:1903169)3.72504460
106regulation of calcium ion transmembrane transporter activity (GO:1901019)3.72504460
107adult heart development (GO:0007512)3.66817508
108amino-acid betaine transport (GO:0015838)3.61363131
109carnitine transport (GO:0015879)3.61363131
110cortical cytoskeleton organization (GO:0030865)3.60709144
111cardiac muscle tissue morphogenesis (GO:0055008)3.59228550
112skeletal muscle tissue regeneration (GO:0043403)3.58337499
113regulation of skeletal muscle cell differentiation (GO:2001014)3.58012074
114negative regulation of muscle contraction (GO:0045932)3.57902685
115positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.56916765
116regulation of myoblast differentiation (GO:0045661)3.56702263
117secretory granule organization (GO:0033363)3.53203707
118negative regulation of calcium ion transmembrane transport (GO:1903170)3.53089193
119negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.53089193
120production of molecular mediator of immune response (GO:0002440)3.52997274
121striated muscle atrophy (GO:0014891)3.52702503
122positive regulation of DNA recombination (GO:0045911)3.51927600
123neuronal action potential propagation (GO:0019227)3.50642906
124quinone metabolic process (GO:1901661)3.49179850
125negative regulation of monooxygenase activity (GO:0032769)3.46173751
126positive regulation of myoblast differentiation (GO:0045663)3.45508422
127hexose biosynthetic process (GO:0019319)3.44611164
128regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.42889027
129myotube differentiation (GO:0014902)3.41698777
130tricarboxylic acid cycle (GO:0006099)3.41696900
131nucleotide salvage (GO:0043173)3.40386619
132cardiac muscle adaptation (GO:0014887)3.40241787
133cardiac muscle hypertrophy in response to stress (GO:0014898)3.40241787
134muscle hypertrophy in response to stress (GO:0003299)3.40241787
135cardiac muscle cell development (GO:0055013)3.39359272
136* response to activity (GO:0014823)3.38998798
137striated muscle tissue development (GO:0014706)3.38872511
138myofibril assembly (GO:0030239)3.38736742
139regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.36639014
140muscle cell development (GO:0055001)3.36410888
141syncytium formation by plasma membrane fusion (GO:0000768)3.36110193
142muscle atrophy (GO:0014889)3.33854038
143purine nucleobase metabolic process (GO:0006144)3.33794079
144negative regulation of alpha-beta T cell activation (GO:0046636)3.33784772
145T-helper cell differentiation (GO:0042093)3.33019456
146CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.33019456
147cellular carbohydrate catabolic process (GO:0044275)3.28782885
148regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.28606979
149activation of protein kinase A activity (GO:0034199)3.27928370
150regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.25558426
151muscle system process (GO:0003012)3.25489470
152regulation of myotube differentiation (GO:0010830)3.25109679
153response to protozoan (GO:0001562)3.25082712
154regulation of relaxation of muscle (GO:1901077)3.23903430
155regulation of sequestering of triglyceride (GO:0010889)3.23285521
156regulation of cell communication by electrical coupling (GO:0010649)3.22552607
157regulation of the force of heart contraction (GO:0002026)3.21670390
158innate immune response in mucosa (GO:0002227)3.20338141
159regulation of membrane lipid distribution (GO:0097035)3.18460741
160positive regulation of cation channel activity (GO:2001259)3.17661009
161neuromuscular synaptic transmission (GO:0007274)3.17584502
162positive regulation of activated T cell proliferation (GO:0042104)3.15865796
163positive regulation of glucose import (GO:0046326)3.13933163
164positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.10627151
165Peyers patch development (GO:0048541)3.08517853
166mucosal-associated lymphoid tissue development (GO:0048537)3.08517853
167positive regulation of isotype switching (GO:0045830)2.98352817
168response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.97699381
169phospholipid scrambling (GO:0017121)11.2617276

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.14176028
2NOTCH1_17114293_ChIP-ChIP_T-ALL_Human5.16460846
3EZH2_22144423_ChIP-Seq_EOC_Human4.57526950
4ZNF263_19887448_ChIP-Seq_K562_Human4.48808895
5STAT3_1855785_ChIP-Seq_MESCs_Mouse3.17299592
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.16063219
7ESR1_20079471_ChIP-ChIP_T-47D_Human2.95003288
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.72010396
9TP63_17297297_ChIP-ChIP_HaCaT_Human2.70593883
10ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.63526870
11RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.56637873
12CDX2_19796622_ChIP-Seq_MESCs_Mouse2.47120706
13MYC_18555785_ChIP-Seq_MESCs_Mouse2.46355057
14ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.40327083
15PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse2.39314980
16PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.34361170
17SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.32242087
18THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.31823635
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.30464479
20TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.20100927
21CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.06861748
22EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.00475195
23EP300_21415370_ChIP-Seq_HL-1_Mouse1.97694397
24MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.95665830
25NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.93952705
26ESR1_15608294_ChIP-ChIP_MCF-7_Human1.91043885
27BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.88282267
28SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.82302014
29ZNF274_21170338_ChIP-Seq_K562_Hela1.81782088
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.77507075
31IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.75767510
32NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.71186965
33SCL_19346495_ChIP-Seq_HPC-7_Human1.68289299
34NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.67225589
35ESR1_21235772_ChIP-Seq_MCF-7_Human1.63395627
36NANOG_18555785_ChIP-Seq_MESCs_Mouse1.62610105
37HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.61525758
38EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.52479725
39YY1_22570637_ChIP-Seq_MALME-3M_Human1.44743755
40DROSHA_22980978_ChIP-Seq_HELA_Human1.43302978
41BCOR_27268052_Chip-Seq_Bcells_Human1.43197934
42SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.42763698
43ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.42074541
44HIF1A_21447827_ChIP-Seq_MCF-7_Human1.41345060
45BCL6_27268052_Chip-Seq_Bcells_Human1.40898112
46* CTCF_27219007_Chip-Seq_Bcells_Human1.40135677
47SOX2_18555785_ChIP-Seq_MESCs_Mouse1.40108869
48TBX20_22328084_ChIP-Seq_HEART_Mouse1.40010194
49TBX20_22080862_ChIP-Seq_HEART_Mouse1.40010194
50LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.35200340
51GATA2_21666600_ChIP-Seq_HMVEC_Human1.34050848
52AR_21572438_ChIP-Seq_LNCaP_Human1.33216241
53ESR2_21235772_ChIP-Seq_MCF-7_Human1.31877179
54* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30645157
55SOX2_18692474_ChIP-Seq_MEFs_Mouse1.27499488
56PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.26706574
57EGR1_19032775_ChIP-ChIP_M12_Human1.25935412
58TCF3_18692474_ChIP-Seq_MEFs_Mouse1.25440078
59P300_27268052_Chip-Seq_Bcells_Human1.24908405
60GATA1_19941826_ChIP-Seq_K562_Human1.23158144
61TCF7_22412390_ChIP-Seq_EML_Mouse1.22148891
62KDM2B_26808549_Chip-Seq_DND41_Human1.21110542
63IKZF1_21737484_ChIP-ChIP_HCT116_Human1.19664986
64SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.19506941
65CTCF_21964334_Chip-Seq_Bcells_Human1.18700372
66GATA2_22383799_ChIP-Seq_G1ME_Mouse1.18692191
67VDR_21846776_ChIP-Seq_THP-1_Human1.18641541
68NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.17540208
69SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.17364337
70* SA1_27219007_Chip-Seq_Bcells_Human1.17346149
71NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.17138027
72* GATA1_19941827_ChIP-Seq_MEL_Mouse1.16675033
73P68_20966046_ChIP-Seq_HELA_Human1.14790805
74GATA1_22383799_ChIP-Seq_G1ME_Mouse1.13997465
75RBPJ_22232070_ChIP-Seq_NCS_Mouse1.13781861
76RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.12728610
77RARB_27405468_Chip-Seq_BRAIN_Mouse1.12398191
78* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.11628945
79SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.10670906
80STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.10163592
81RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.09695637
82TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.09687816
83NFIB_24661679_ChIP-Seq_LUNG_Mouse1.09444872
84MYC_27129775_Chip-Seq_CORNEA_Mouse1.08803287
85NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.07950627
86IGF1R_20145208_ChIP-Seq_DFB_Human1.07828521
87PPARA_22158963_ChIP-Seq_LIVER_Mouse1.06606149
88CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.06327295
89STAT1_20625510_ChIP-Seq_HELA_Human1.05908293
90TCF3_18692474_ChIP-Seq_MESCs_Mouse1.05841314
91CTCF_26484167_Chip-Seq_Bcells_Mouse1.05026861
92TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.04739709
93POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.03163672
94OCT4_20526341_ChIP-Seq_ESCs_Human1.02720709
95ETS1_21867929_ChIP-Seq_TH2_Mouse1.02691099
96ZFP281_18757296_ChIP-ChIP_E14_Mouse1.01716668
97PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01711954
98GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.00878117
99POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.00772071
100RXR_22158963_ChIP-Seq_LIVER_Mouse1.00167326
101RACK7_27058665_Chip-Seq_MCF-7_Human1.00148200
102EZH2_27294783_Chip-Seq_ESCs_Mouse0.99728148
103FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.99711474
104SPI1_23127762_ChIP-Seq_K562_Human0.99632985
105GATA2_19941826_ChIP-Seq_K562_Human0.99473653
106CTCF_27219007_Chip-Seq_ERYTHROID_Human0.98687275
107ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.98286771
108SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.98257165
109TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97822516
110GATA4_21415370_ChIP-Seq_HL-1_Mouse0.97772271
111SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.96876501
112SPI1_20517297_ChIP-Seq_HL60_Human0.96815506
113ELF1_20517297_ChIP-Seq_JURKAT_Human0.96248825
114RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.96127350
115ELK3_25401928_ChIP-Seq_HUVEC_Human0.95428652
116ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.94937730
117NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.94879966
118CRX_20693478_ChIP-Seq_RETINA_Mouse0.94761334
119* MYC_18358816_ChIP-ChIP_MESCs_Mouse0.93346860
120SMC3_22415368_ChIP-Seq_MEFs_Mouse0.93218361
121SMC1_22415368_ChIP-Seq_MEFs_Mouse0.91593717
122TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.90719488
123DNAJC2_21179169_ChIP-ChIP_NT2_Human0.90577909
124TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.90503992
125* SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.89741520
126NANOG_16153702_ChIP-ChIP_HESCs_Human0.89184718
127P63_26484246_Chip-Seq_KERATINOCYTES_Human0.89056212
128SUZ12_27294783_Chip-Seq_NPCs_Mouse0.87655748
129CTCF_21964334_ChIP-Seq_BJAB-B_Human0.87567047
130SRY_22984422_ChIP-ChIP_TESTIS_Rat0.87473335
131FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.87265582
132CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.87162561
133NOTCH1_21737748_ChIP-Seq_TLL_Human0.86994802
134P53_22127205_ChIP-Seq_FIBROBLAST_Human0.86601832
135OCT4_21477851_ChIP-Seq_ESCs_Mouse0.86506817
136BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.86418681
137LXR_22292898_ChIP-Seq_THP-1_Human0.85841234
138KDM2B_26808549_Chip-Seq_SUP-B15_Human0.85756651
139RUNX_20019798_ChIP-Seq_JUKART_Human0.85551833
140CSB_26484114_Chip-Seq_FIBROBLAST_Human0.85334158
141MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.84518454
142LXR_22158963_ChIP-Seq_LIVER_Mouse0.83578683
143SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.82819671
144PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.82319066
145DPY_21335234_ChIP-Seq_ESCs_Mouse0.81278113
146EZH2_27294783_Chip-Seq_NPCs_Mouse0.81160508
147GATA1_19941827_ChIP-Seq_MEL86_Mouse0.80077202
148EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.79151550
149ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.78792627
150MAF_26560356_Chip-Seq_TH1_Human0.76188608
151TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.75957377
152CBX2_27304074_Chip-Seq_ESCs_Mouse0.74889109
153STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.74870093
154MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.74656251
155CLOCK_20551151_ChIP-Seq_293T_Human0.74576112
156GATA6_21074721_ChIP-Seq_CACO-2_Human0.73607942
157GATA3_21867929_ChIP-Seq_CD8_Mouse0.71055143
158NANOG_20526341_ChIP-Seq_ESCs_Human0.70634112
159EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.69914265
160RAD21_21589869_ChIP-Seq_MESCs_Mouse0.69322946
161TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.68282375
162SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.67386819

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004145_abnormal_muscle_electrophysio6.55593282
2MP0000749_muscle_degeneration5.60337599
3MP0001348_abnormal_lacrimal_gland5.13711174
4MP0003646_muscle_fatigue4.97913669
5MP0000751_myopathy4.80644201
6MP0000747_muscle_weakness3.97421419
7MP0005451_abnormal_body_composition3.73931519
8MP0002106_abnormal_muscle_physiology3.57499307
9MP0002837_dystrophic_cardiac_calcinosis3.08057165
10* MP0000759_abnormal_skeletal_muscle3.03314484
11MP0004036_abnormal_muscle_relaxation3.02019768
12MP0004510_myositis2.96507166
13MP0005310_abnormal_salivary_gland2.95480886
14MP0004087_abnormal_muscle_fiber2.93074745
15MP0005369_muscle_phenotype2.91806587
16MP0001873_stomach_inflammation2.76302824
17MP0003950_abnormal_plasma_membrane2.73322453
18MP0002269_muscular_atrophy2.72310864
19MP0005330_cardiomyopathy2.57712835
20MP0000750_abnormal_muscle_regeneration2.36295615
21MP0006036_abnormal_mitochondrial_physio2.31029805
22MP0003221_abnormal_cardiomyocyte_apopto2.25199762
23* MP0005620_abnormal_muscle_contractility2.17851825
24MP0001853_heart_inflammation2.13472748
25MP0004130_abnormal_muscle_cell2.12039415
26MP0006082_CNS_inflammation2.05405397
27MP0000733_abnormal_muscle_development2.01077561
28MP0004233_abnormal_muscle_weight1.74696455
29* MP0002332_abnormal_exercise_endurance1.69660888
30MP0004484_altered_response_of1.56641831
31MP0000013_abnormal_adipose_tissue1.48744073
32MP0004084_abnormal_cardiac_muscle1.45222599
33MP0009697_abnormal_copulation1.42953715
34MP0010630_abnormal_cardiac_muscle1.38499729
35MP0003806_abnormal_nucleotide_metabolis1.34837640
36MP0002108_abnormal_muscle_morphology1.31882399
37MP0005166_decreased_susceptibility_to1.24620212
38MP0002254_reproductive_system_inflammat1.21512080
39MP0004270_analgesia1.20459840
40MP0003566_abnormal_cell_adhesion1.18620796
41* MP0005266_abnormal_metabolism1.18374095
42MP0010368_abnormal_lymphatic_system1.17101165
43MP0006292_abnormal_olfactory_placode1.15098243
44MP0005501_abnormal_skin_physiology1.10942397
45MP0002822_catalepsy1.03746540
46MP0005083_abnormal_biliary_tract1.03522991
47MP0002971_abnormal_brown_adipose0.99974793
48MP0004215_abnormal_myocardial_fiber0.94639929
49MP0005666_abnormal_adipose_tissue0.93866796
50MP0001661_extended_life_span0.92213348
51MP0006035_abnormal_mitochondrial_morpho0.90511441
52MP0005167_abnormal_blood-brain_barrier0.86076656
53MP0002972_abnormal_cardiac_muscle0.85047829
54MP0005165_increased_susceptibility_to0.83826536
55MP0001835_abnormal_antigen_presentation0.83776851
56MP0004185_abnormal_adipocyte_glucose0.83740471
57MP0005319_abnormal_enzyme/_coenzyme0.81801102
58MP0003828_pulmonary_edema0.81328691
59MP0000343_altered_response_to0.80539550
60MP0001544_abnormal_cardiovascular_syste0.78513911
61MP0005385_cardiovascular_system_phenoty0.78513911
62MP0000003_abnormal_adipose_tissue0.78495816
63MP0003045_fibrosis0.77346275
64MP0008872_abnormal_physiological_respon0.76784367
65MP0000685_abnormal_immune_system0.71513179
66MP0008775_abnormal_heart_ventricle0.71182413
67MP0001177_atelectasis0.69397735
68MP0010329_abnormal_lipoprotein_level0.68886652
69MP0003879_abnormal_hair_cell0.68728492
70MP0005584_abnormal_enzyme/coenzyme_acti0.66462042
71MP0004147_increased_porphyrin_level0.65984596
72MP0001851_eye_inflammation0.63472904
73MP0006138_congestive_heart_failure0.62510546
74MP0004134_abnormal_chest_morphology0.62347486
75MP0002970_abnormal_white_adipose0.60553149
76MP0003137_abnormal_impulse_conducting0.60271721
77MP0000372_irregular_coat_pigmentation0.59822567
78MP0004085_abnormal_heartbeat0.58879141
79* MP0005376_homeostasis/metabolism_phenot0.57162667
80MP0005535_abnormal_body_temperature0.56788715
81MP0002127_abnormal_cardiovascular_syste0.56746822
82MP0005275_abnormal_skin_tensile0.55554707
83MP0002234_abnormal_pharynx_morphology0.55311195
84MP0001186_pigmentation_phenotype0.54713390
85MP0001849_ear_inflammation0.54266016
86MP0009780_abnormal_chondrocyte_physiolo0.53432154
87MP0005670_abnormal_white_adipose0.52906279
88MP0005464_abnormal_platelet_physiology0.51246312
89MP0003786_premature_aging0.50819310
90MP0000762_abnormal_tongue_morphology0.49936639
91MP0002075_abnormal_coat/hair_pigmentati0.49331831
92MP0004957_abnormal_blastocyst_morpholog0.49294144
93MP0002078_abnormal_glucose_homeostasis0.49142456
94MP0001879_abnormal_lymphatic_vessel0.49048858
95MP0008438_abnormal_cutaneous_collagen0.48036826
96MP0003252_abnormal_bile_duct0.47955271
97MP0003567_abnormal_fetal_cardiomyocyte0.47664402
98MP0002796_impaired_skin_barrier0.47264827
99MP0003948_abnormal_gas_homeostasis0.46408834
100MP0000371_diluted_coat_color0.46382402
101MP0004947_skin_inflammation0.45484220
102MP0004043_abnormal_pH_regulation0.44915444
103MP0001299_abnormal_eye_distance/0.43746612
104MP0003705_abnormal_hypodermis_morpholog0.41168935
105MP0001346_abnormal_lacrimal_gland0.40719947
106MP0005375_adipose_tissue_phenotype0.40512173
107MP0001663_abnormal_digestive_system0.40419358
108MP0004142_abnormal_muscle_tone0.39627389
109MP0009672_abnormal_birth_weight0.39605772
110MP0003656_abnormal_erythrocyte_physiolo0.39547171
111MP0009765_abnormal_xenobiotic_induced0.39488551
112MP0002095_abnormal_skin_pigmentation0.39434846
113MP0005452_abnormal_adipose_tissue0.39321640
114MP0004808_abnormal_hematopoietic_stem0.38483947
115MP0008569_lethality_at_weaning0.38223926
116MP0010155_abnormal_intestine_physiology0.37364362
117MP0002128_abnormal_blood_circulation0.36266955
118MP0000266_abnormal_heart_morphology0.36013875
119MP0005448_abnormal_energy_balance0.34246507
120MP0002114_abnormal_axial_skeleton0.34190938
121MP0002638_abnormal_pupillary_reflex0.29829169
122MP0005334_abnormal_fat_pad0.29824463
123MP0010030_abnormal_orbit_morphology0.29394345
124MP0002896_abnormal_bone_mineralization0.28497365
125MP0002734_abnormal_mechanical_nocicepti0.27162662
126MP0009250_abnormal_appendicular_skeleto0.24276728
127MP0001943_abnormal_respiration0.24192001
128MP0000230_abnormal_systemic_arterial0.24180326
129MP0004858_abnormal_nervous_system0.22014610
130MP0002249_abnormal_larynx_morphology0.19948011
131MP0005423_abnormal_somatic_nervous0.18925308
132MP0002066_abnormal_motor_capabilities/c0.18615883
133MP0005332_abnormal_amino_acid0.18152440
134MP0008874_decreased_physiological_sensi0.16922497
135MP0003959_abnormal_lean_body0.15288650
136MP0009115_abnormal_fat_cell0.13811048
137MP0006276_abnormal_autonomic_nervous0.13615297
138MP0005187_abnormal_penis_morphology0.13114615
139MP0002067_abnormal_sensory_capabilities0.11560150

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)9.75448630
2Nemaline bodies (HP:0003798)9.51252144
3Type 1 muscle fiber predominance (HP:0003803)7.84546836
4Distal arthrogryposis (HP:0005684)6.60952647
5Exercise-induced myalgia (HP:0003738)6.50475902
6Progressive muscle weakness (HP:0003323)6.25082728
7Myopathic facies (HP:0002058)6.13905361
8Myoglobinuria (HP:0002913)5.85949485
9Exercise-induced muscle cramps (HP:0003710)5.75853940
10Absent/shortened dynein arms (HP:0200106)5.65747777
11Dynein arm defect of respiratory motile cilia (HP:0012255)5.65747777
12Muscle hypertrophy of the lower extremities (HP:0008968)5.11200516
13Round ear (HP:0100830)5.07126866
14Ulnar deviation of the wrist (HP:0003049)5.01225317
15Nasal polyposis (HP:0100582)4.68567333
16Calf muscle hypertrophy (HP:0008981)4.62473447
17Muscle fiber splitting (HP:0003555)4.55264798
18Difficulty running (HP:0009046)4.21289465
19Abnormality of the nasal mucosa (HP:0000433)4.21219694
20Calcaneovalgus deformity (HP:0001848)4.19218577
21Hyporeflexia of lower limbs (HP:0002600)3.98643159
22Abnormality of skeletal muscle fiber size (HP:0012084)3.79972493
23Rimmed vacuoles (HP:0003805)3.78499304
24Scanning speech (HP:0002168)3.77629988
25EMG: myopathic abnormalities (HP:0003458)3.74668104
26Deformed tarsal bones (HP:0008119)3.74244295
27Muscle stiffness (HP:0003552)3.73543781
28Increased connective tissue (HP:0009025)3.72133404
29Absent phalangeal crease (HP:0006109)3.63438557
30Asymmetric septal hypertrophy (HP:0001670)3.50445876
31Neck muscle weakness (HP:0000467)3.46531173
32Ragged-red muscle fibers (HP:0003200)3.34816796
33Increased variability in muscle fiber diameter (HP:0003557)3.28657014
34Myotonia (HP:0002486)3.25119827
35Abnormality of the calf musculature (HP:0001430)3.21875637
36Frequent falls (HP:0002359)3.15255447
37Areflexia of lower limbs (HP:0002522)3.14730398
38Rhabdomyolysis (HP:0003201)3.13963133
39Abnormal respiratory epithelium morphology (HP:0012253)3.03731373
40Abnormal respiratory motile cilium morphology (HP:0005938)3.03731373
41Abnormal finger flexion creases (HP:0006143)3.01619840
42Abnormal ciliary motility (HP:0012262)2.90837697
43Atrioventricular block (HP:0001678)2.88502970
44Nonprogressive disorder (HP:0003680)2.80493295
45Fetal akinesia sequence (HP:0001989)2.79862396
46Fatigable weakness (HP:0003473)2.65273348
47Abnormality of the neuromuscular junction (HP:0003398)2.65273348
48Postural instability (HP:0002172)2.60865043
49Difficulty climbing stairs (HP:0003551)2.59088779
50EMG: neuropathic changes (HP:0003445)2.54218245
51Abnormality of the calcaneus (HP:0008364)2.44543202
52Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.42400524
53Malignant hyperthermia (HP:0002047)2.42205699
54Limb-girdle muscle atrophy (HP:0003797)2.41138770
55Heart block (HP:0012722)2.40973926
56Facial diplegia (HP:0001349)2.39674602
57Weak cry (HP:0001612)2.38088060
58Dilated cardiomyopathy (HP:0001644)2.33163351
59Abnormal atrioventricular conduction (HP:0005150)2.29140379
60Abnormality of the left ventricular outflow tract (HP:0011103)2.23052366
61Subaortic stenosis (HP:0001682)2.23052366
62Distal lower limb muscle weakness (HP:0009053)2.21993776
63Slender build (HP:0001533)2.18731443
64Spinal rigidity (HP:0003306)2.16053174
65Type 2 muscle fiber atrophy (HP:0003554)2.15229810
66Bulbar palsy (HP:0001283)2.14968947
67Abnormality of the musculature of the pelvis (HP:0001469)2.13859811
68Abnormality of the hip-girdle musculature (HP:0001445)2.13859811
69Pelvic girdle muscle weakness (HP:0003749)2.12180066
70Hyperkalemia (HP:0002153)2.11235929
71Shoulder girdle muscle weakness (HP:0003547)2.09339157
72Centrally nucleated skeletal muscle fibers (HP:0003687)2.07087286
73Mildly elevated creatine phosphokinase (HP:0008180)2.06459879
74Hip contracture (HP:0003273)2.05686536
75Lipoatrophy (HP:0100578)2.00254611
76Muscle fiber inclusion bodies (HP:0100299)10.6968075
77Muscle fiber atrophy (HP:0100295)1.98900115
78Abnormality of the foot musculature (HP:0001436)1.98829594
79Bundle branch block (HP:0011710)1.98385504
80Abnormal respiratory motile cilium physiology (HP:0012261)1.95850141
81Gowers sign (HP:0003391)1.95248779
82Lower limb amyotrophy (HP:0007210)1.94577917
83Scapular winging (HP:0003691)1.91133614
84Metatarsus adductus (HP:0001840)1.87632337
85Proximal amyotrophy (HP:0007126)1.83978932
86Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.83938763
87Generalized muscle weakness (HP:0003324)1.83473549
88Foot dorsiflexor weakness (HP:0009027)1.82488187
89Long clavicles (HP:0000890)1.81364948
90Popliteal pterygium (HP:0009756)1.81179522
91Waddling gait (HP:0002515)1.79627446
92Abnormality of the shoulder girdle musculature (HP:0001435)1.72933076
93Sudden death (HP:0001699)1.72319384
94Distal lower limb amyotrophy (HP:0008944)1.70155743
95Hypoplastic ischia (HP:0003175)1.69751292
96Muscular dystrophy (HP:0003560)1.68119812
97Paralysis (HP:0003470)1.66521815
98Exercise intolerance (HP:0003546)1.65662977
99Respiratory insufficiency due to muscle weakness (HP:0002747)1.62862623
100Respiratory distress (HP:0002098)1.62432866
101Ulnar deviation of finger (HP:0009465)1.60347596
102Congenital hip dislocation (HP:0001374)1.58304490
103Easy fatigability (HP:0003388)1.56953018
104Limited hip movement (HP:0008800)1.56925485
105Spastic paraparesis (HP:0002313)1.55214858
106Progressive external ophthalmoplegia (HP:0000590)1.50401028
107Ventricular arrhythmia (HP:0004308)1.50373725
108Increased IgE level (HP:0003212)1.48968005
109Abnormal EKG (HP:0003115)1.47308014
110Limb-girdle muscle weakness (HP:0003325)1.44553167
111Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.43156894
112Ventricular tachycardia (HP:0004756)1.42360461
113Achilles tendon contracture (HP:0001771)1.41467318
114Ulnar deviation of the hand or of fingers of the hand (HP:0001193)1.40055677
115Increased intramyocellular lipid droplets (HP:0012240)1.38871395
116Breech presentation (HP:0001623)1.33859503
117Amniotic constriction ring (HP:0009775)1.33047216
118Abnormality of placental membranes (HP:0011409)1.33047216
119Oligomenorrhea (HP:0000876)1.30722162
120Increased muscle lipid content (HP:0009058)1.29882424
121Adducted thumb (HP:0001181)1.28774783
122Steppage gait (HP:0003376)1.28341832

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN5.17231328
2PINK14.05282771
3MUSK3.96921604
4PIK3CG3.71707414
5PHKG22.99320134
6PHKG12.99320134
7NME12.82437467
8MAP3K122.39684992
9MAP2K32.29146761
10OBSCN10.1133768
11TGFBR21.74177919
12CDK91.64279539
13MAP3K71.63005673
14NEK11.61074266
15BCKDK1.57603914
16MAP2K61.50639887
17DMPK1.44509624
18PDK31.43163418
19PDK41.43163418
20CDK191.35922924
21EEF2K1.20513874
22TRPM71.17716663
23EIF2AK11.14369240
24ROCK11.08453598
25MAPK121.04922802
26ERN11.00515147
27TIE10.99768626
28MKNK20.98536817
29RPS6KA50.97949938
30CCNB10.95779046
31MYLK0.93309777
32MAP2K40.91594345
33MARK10.91198460
34MAP3K110.88371982
35STK160.87883629
36CHUK0.87155893
37DYRK30.85165332
38PDK20.82835222
39MAP3K130.82628285
40LIMK10.80935761
41PRKD20.80837499
42MKNK10.76137092
43TRIB30.71934159
44AKT20.64212883
45RIPK10.63933026
46TGFBR10.63912459
47PRKAA20.60394382
48PIK3CA0.60096411
49PAK40.58893640
50MAPKAPK30.58887786
51EIF2AK30.58792624
52ILK0.57232880
53KSR20.56042148
54RPS6KB20.51924021
55HIPK20.51687640
56MAP3K30.47267403
57NME20.47096210
58DYRK1B0.46964421
59PKN10.46787597
60MATK0.46783420
61PRPF4B0.46168286
62BMX0.45444734
63CAMK2G0.44129873
64MAP2K10.43312511
65CAMK10.42528160
66MAP4K10.41960919
67PKN20.40769579
68CAMK2D0.40188952
69RPS6KA10.38748804
70NEK90.38401532
71MAPK110.36896864
72TAOK20.36872926
73CAMK2B0.35742922
74MAP3K60.35421510
75PRKCH0.34654910
76MARK20.32828959
77SIK10.30092420
78SGK30.28847760
79ZAP700.27786719
80MAPK130.27596102
81RPS6KB10.27367852
82TEC0.26749812
83MAP3K100.26080507
84PIM10.24942442
85PDPK10.24906169
86CAMK40.24612801
87MAPK100.24249252
88CDK60.23988404
89EPHB10.23538593
90LATS20.23239597
91MAPK80.22861894
92RPS6KA30.22752267
93NEK60.22426087
94TNK20.21436196
95DAPK10.21342129
96MAPK40.20828607
97MAPK90.19899632
98DAPK30.19876493
99PDK10.19634057
100LRRK20.19446076
101* PRKACA0.18902276
102ARAF0.18862118
103TXK0.18672815
104TAOK10.18390481
105MARK30.18065937
106PRKACG0.17681493
107SGK20.17650189
108PRKD10.16824763
109CDK50.16083757
110ERBB30.15719812
111AURKB0.15514195
112ICK0.15461708
113RPS6KC10.15397987
114RPS6KL10.15397987
115TYK20.15062017
116PRKAA10.14910804
117DDR20.14831829
118IRAK10.14444722
119DAPK20.14175629
120STK110.13784774
121MOS0.13582667
122SGK2230.13142227
123SGK4940.13142227
124MTOR0.12863134
125ABL10.12599130
126FGFR30.12486741
127RAF10.11736174
128CSF1R0.11707757
129EPHA30.11705133
130MAPK70.11546383
131MAP3K80.11342524
132TBK10.11040072
133RPS6KA60.10675794
134MAP3K10.10494951
135PRKACB0.10257061
136KSR10.09724648
137PRKG10.09116240
138CDC42BPA0.08114612
139CAMK2A0.07672773
140SGK10.07578916
141NLK0.07269130
142IKBKB0.07154562
143PTK2B0.07041468
144JAK20.05923956

Predicted pathways (KEGG)

RankGene SetZ-score
1Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001305.63092994
2Asthma_Homo sapiens_hsa053104.48865321
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.40979156
4Allograft rejection_Homo sapiens_hsa053303.40028625
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.37054735
6Insulin signaling pathway_Homo sapiens_hsa049102.86460987
7Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.65078256
8Cardiac muscle contraction_Homo sapiens_hsa042602.60793135
9Autoimmune thyroid disease_Homo sapiens_hsa053202.31115989
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.29356525
11Parkinsons disease_Homo sapiens_hsa050122.26395407
12Ribosome_Homo sapiens_hsa030102.10722544
13Dilated cardiomyopathy_Homo sapiens_hsa054141.93962534
14Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.83907001
15Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.78338678
16Intestinal immune network for IgA production_Homo sapiens_hsa046721.74687253
17Carbon metabolism_Homo sapiens_hsa012001.74665505
18ABC transporters_Homo sapiens_hsa020101.71023940
19Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.70462808
20RNA polymerase_Homo sapiens_hsa030201.67852512
21Starch and sucrose metabolism_Homo sapiens_hsa005001.63725134
22Biosynthesis of amino acids_Homo sapiens_hsa012301.60600654
23Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.59986104
24Glucagon signaling pathway_Homo sapiens_hsa049221.55115684
25Oxidative phosphorylation_Homo sapiens_hsa001901.47825175
26Alzheimers disease_Homo sapiens_hsa050101.42074838
27Circadian rhythm_Homo sapiens_hsa047101.38455760
28Fatty acid degradation_Homo sapiens_hsa000711.35634199
29Fructose and mannose metabolism_Homo sapiens_hsa000511.34130407
30Caffeine metabolism_Homo sapiens_hsa002321.29851260
31Oxytocin signaling pathway_Homo sapiens_hsa049211.29376118
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.29306857
33Propanoate metabolism_Homo sapiens_hsa006401.28983483
34Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.28069572
35Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.26631351
36Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.22383538
37Galactose metabolism_Homo sapiens_hsa000521.20856532
38Pyruvate metabolism_Homo sapiens_hsa006201.17322869
39Insulin resistance_Homo sapiens_hsa049311.14707853
40Gastric acid secretion_Homo sapiens_hsa049711.07770991
41Purine metabolism_Homo sapiens_hsa002301.05246289
42Sphingolipid metabolism_Homo sapiens_hsa006001.00642822
43Huntingtons disease_Homo sapiens_hsa050160.99542275
44Leishmaniasis_Homo sapiens_hsa051400.99020683
45Adipocytokine signaling pathway_Homo sapiens_hsa049200.98709472
46Long-term potentiation_Homo sapiens_hsa047200.90894718
47Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.81365134
48Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.77667053
49Phenylalanine metabolism_Homo sapiens_hsa003600.76882223
50AMPK signaling pathway_Homo sapiens_hsa041520.76461058
51Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.74509886
52Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.71725752
53Arginine biosynthesis_Homo sapiens_hsa002200.67638714
54Spliceosome_Homo sapiens_hsa030400.66515262
55Jak-STAT signaling pathway_Homo sapiens_hsa046300.64885726
56Calcium signaling pathway_Homo sapiens_hsa040200.62761568
57Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61016488
58Platelet activation_Homo sapiens_hsa046110.60653551
59Central carbon metabolism in cancer_Homo sapiens_hsa052300.59743987
60Fatty acid metabolism_Homo sapiens_hsa012120.58754792
61alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.56930107
62Fatty acid biosynthesis_Homo sapiens_hsa000610.54770123
63Viral myocarditis_Homo sapiens_hsa054160.53948856
64Pentose phosphate pathway_Homo sapiens_hsa000300.53685651
65Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.52562983
66Tight junction_Homo sapiens_hsa045300.51336584
67Aldosterone synthesis and secretion_Homo sapiens_hsa049250.49447135
68Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.48763157
69Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48013548
70Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47656928
71Arginine and proline metabolism_Homo sapiens_hsa003300.46266988
72DNA replication_Homo sapiens_hsa030300.45577009
73Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.45097505
74Insulin secretion_Homo sapiens_hsa049110.45027557
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.44449890
76MAPK signaling pathway_Homo sapiens_hsa040100.43997221
77Fat digestion and absorption_Homo sapiens_hsa049750.43967307
78Long-term depression_Homo sapiens_hsa047300.43879303
79Systemic lupus erythematosus_Homo sapiens_hsa053220.43781624
80Vascular smooth muscle contraction_Homo sapiens_hsa042700.43385727
81Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.39838096
82Linoleic acid metabolism_Homo sapiens_hsa005910.38767787
83Salivary secretion_Homo sapiens_hsa049700.37937143
84beta-Alanine metabolism_Homo sapiens_hsa004100.37367561
85Butanoate metabolism_Homo sapiens_hsa006500.35950693
86Transcriptional misregulation in cancer_Homo sapiens_hsa052020.34444405
87mTOR signaling pathway_Homo sapiens_hsa041500.34293811
88Cholinergic synapse_Homo sapiens_hsa047250.33658119
89VEGF signaling pathway_Homo sapiens_hsa043700.32927601
90HIF-1 signaling pathway_Homo sapiens_hsa040660.32895064
91Glioma_Homo sapiens_hsa052140.32869135
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.32291294
93Neurotrophin signaling pathway_Homo sapiens_hsa047220.30293122
94Renin secretion_Homo sapiens_hsa049240.29849318
95Type II diabetes mellitus_Homo sapiens_hsa049300.29676852
96Nitrogen metabolism_Homo sapiens_hsa009100.28237538
97Focal adhesion_Homo sapiens_hsa045100.27994590
98Amoebiasis_Homo sapiens_hsa051460.27735334
99cGMP-PKG signaling pathway_Homo sapiens_hsa040220.27718230
100Regulation of autophagy_Homo sapiens_hsa041400.26392499
101cAMP signaling pathway_Homo sapiens_hsa040240.26174334
102Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.25146987
103Primary immunodeficiency_Homo sapiens_hsa053400.25134676
104Lysine degradation_Homo sapiens_hsa003100.25097245
105Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.24666162
106Measles_Homo sapiens_hsa051620.24625687
107Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.23957930
108Prolactin signaling pathway_Homo sapiens_hsa049170.23252691
109Regulation of actin cytoskeleton_Homo sapiens_hsa048100.22722160
110FoxO signaling pathway_Homo sapiens_hsa040680.22603853
111Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.22499141
112Peroxisome_Homo sapiens_hsa041460.22244508
113Metabolic pathways_Homo sapiens_hsa011000.21905233
114Fatty acid elongation_Homo sapiens_hsa000620.21558777
115Arachidonic acid metabolism_Homo sapiens_hsa005900.21391780
116PPAR signaling pathway_Homo sapiens_hsa033200.20888894
117Legionellosis_Homo sapiens_hsa051340.20542893
118Carbohydrate digestion and absorption_Homo sapiens_hsa049730.19739855
119Thyroid cancer_Homo sapiens_hsa052160.19736127
120GnRH signaling pathway_Homo sapiens_hsa049120.19449897
121Base excision repair_Homo sapiens_hsa034100.18829815
122Hematopoietic cell lineage_Homo sapiens_hsa046400.18408314
123Tryptophan metabolism_Homo sapiens_hsa003800.17965537
124Amphetamine addiction_Homo sapiens_hsa050310.17916202
125Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.17503058
126Leukocyte transendothelial migration_Homo sapiens_hsa046700.17462735
127Non-small cell lung cancer_Homo sapiens_hsa052230.16828800
128Melanogenesis_Homo sapiens_hsa049160.15902202
129Renal cell carcinoma_Homo sapiens_hsa052110.15801061
130SNARE interactions in vesicular transport_Homo sapiens_hsa041300.15254368
131Circadian entrainment_Homo sapiens_hsa047130.14023253
132Sphingolipid signaling pathway_Homo sapiens_hsa040710.13401899
133Chemical carcinogenesis_Homo sapiens_hsa052040.12606272
134Adherens junction_Homo sapiens_hsa045200.12424472
135Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.12114274
136Histidine metabolism_Homo sapiens_hsa003400.11347946
137AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.10920560
138Phosphatidylinositol signaling system_Homo sapiens_hsa040700.09945977
139Pancreatic secretion_Homo sapiens_hsa049720.08912530
140Acute myeloid leukemia_Homo sapiens_hsa052210.08881393

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