SMTNL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of relaxation of muscle (GO:1901077)8.09824177
2actin-myosin filament sliding (GO:0033275)7.47046962
3muscle filament sliding (GO:0030049)7.47046962
4creatine metabolic process (GO:0006600)6.87543415
5regulation of skeletal muscle contraction (GO:0014819)6.26765993
6actin-mediated cell contraction (GO:0070252)6.26460717
7skeletal muscle contraction (GO:0003009)5.39851835
8glycogen catabolic process (GO:0005980)5.37033824
9regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)5.13435361
10regulation of actin filament-based movement (GO:1903115)5.10966600
11glucan catabolic process (GO:0009251)5.03975372
12glucan biosynthetic process (GO:0009250)4.84787383
13glycogen biosynthetic process (GO:0005978)4.84787383
14cellular polysaccharide catabolic process (GO:0044247)4.76254542
15myofibril assembly (GO:0030239)4.74305674
16striated muscle hypertrophy (GO:0014897)4.72133330
17NADH metabolic process (GO:0006734)4.72122401
18skeletal muscle tissue development (GO:0007519)4.71944460
19sarcomere organization (GO:0045214)4.69663967
20actin filament-based movement (GO:0030048)4.46507709
21IMP metabolic process (GO:0046040)4.42456173
22sarcoplasmic reticulum calcium ion transport (GO:0070296)4.42349516
23IMP biosynthetic process (GO:0006188)4.41906146
24polysaccharide catabolic process (GO:0000272)4.28493023
25response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.22287607
26muscle hypertrophy (GO:0014896)4.20523357
27skeletal muscle adaptation (GO:0043501)4.15368044
28positive regulation of myotube differentiation (GO:0010831)4.09789933
29regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.06486734
30regulation of striated muscle contraction (GO:0006942)4.06453360
31regulation of gene silencing by RNA (GO:0060966)4.06413169
32regulation of posttranscriptional gene silencing (GO:0060147)4.06413169
33regulation of gene silencing by miRNA (GO:0060964)4.06413169
34muscle organ development (GO:0007517)4.03112490
35muscle structure development (GO:0061061)4.02650391
36fructose metabolic process (GO:0006000)3.95559831
37striated muscle contraction (GO:0006941)3.93057595
38glycogen metabolic process (GO:0005977)3.89379999
39positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.88062884
402-oxoglutarate metabolic process (GO:0006103)3.85252618
41paraxial mesoderm development (GO:0048339)3.82816710
42cardiac myofibril assembly (GO:0055003)3.81920212
43glucan metabolic process (GO:0044042)3.81372386
44cellular glucan metabolic process (GO:0006073)3.81372386
45regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.77172567
46muscle organ morphogenesis (GO:0048644)3.75417362
47gluconeogenesis (GO:0006094)3.72300139
48muscle adaptation (GO:0043500)3.70417396
49cardiac muscle hypertrophy in response to stress (GO:0014898)3.69668573
50muscle hypertrophy in response to stress (GO:0003299)3.69668573
51cardiac muscle adaptation (GO:0014887)3.69668573
52regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.68343657
53regulation of calcium ion transmembrane transporter activity (GO:1901019)3.67043407
54regulation of calcium ion transmembrane transport (GO:1903169)3.67043407
55carnitine shuttle (GO:0006853)3.63399016
56regulation of the force of heart contraction (GO:0002026)3.61877817
57response to activity (GO:0014823)3.60265294
58myoblast fusion (GO:0007520)3.57355347
59tricarboxylic acid cycle (GO:0006099)3.55083857
60regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.52317445
61regulation of myoblast differentiation (GO:0045661)3.48533161
62muscle cell development (GO:0055001)3.47940958
63regulation of skeletal muscle cell differentiation (GO:2001014)3.45409446
64heart contraction (GO:0060047)3.45327558
65heart process (GO:0003015)3.45327558
66negative regulation of calcium ion transmembrane transport (GO:1903170)3.43861795
67negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.43861795
68cardiac muscle cell development (GO:0055013)3.42333224
69myotube differentiation (GO:0014902)3.40207624
70neuronal action potential propagation (GO:0019227)3.37753146
71actomyosin structure organization (GO:0031032)3.36691864
72striated muscle tissue development (GO:0014706)3.35528271
73hexose biosynthetic process (GO:0019319)3.32620507
74positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.29532347
75cardiac muscle tissue morphogenesis (GO:0055008)3.28414553
76negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.28185416
77cardiac cell development (GO:0055006)3.24204113
78regulation of nuclear cell cycle DNA replication (GO:0033262)3.22238827
79relaxation of muscle (GO:0090075)3.20239289
80positive regulation of myoblast differentiation (GO:0045663)3.20148586
81positive regulation of cation channel activity (GO:2001259)3.19107762
82regulation of muscle system process (GO:0090257)3.17738938
83regulation of helicase activity (GO:0051095)3.17179218
84cytidine deamination (GO:0009972)3.16914189
85cytidine metabolic process (GO:0046087)3.16914189
86cytidine catabolic process (GO:0006216)3.16914189
87oxidative phosphorylation (GO:0006119)3.16487621
88syncytium formation by plasma membrane fusion (GO:0000768)3.11381068
89muscle tissue morphogenesis (GO:0060415)3.11270852
90ubiquinone biosynthetic process (GO:0006744)3.09252497
91regulation of membrane repolarization (GO:0060306)3.09159690
92response to inactivity (GO:0014854)3.08448401
93DNA demethylation (GO:0080111)3.04167560
94pyrimidine ribonucleoside catabolic process (GO:0046133)2.98468890
95negative regulation of androgen receptor signaling pathway (GO:0060766)2.97144338
96DNA strand renaturation (GO:0000733)2.96598299
97somatic diversification of immune receptors via somatic mutation (GO:0002566)2.88901000
98somatic hypermutation of immunoglobulin genes (GO:0016446)2.88901000
99cardiac muscle contraction (GO:0060048)2.87748314
100negative regulation of skeletal muscle tissue development (GO:0048642)2.83921815
101skeletal muscle tissue regeneration (GO:0043403)2.83822611
102regulation of telomere maintenance via telomerase (GO:0032210)2.80972482
103notochord development (GO:0030903)2.80418557
104muscle contraction (GO:0006936)2.76793263
105adult heart development (GO:0007512)2.74260703
106skeletal muscle fiber development (GO:0048741)2.70103406
107positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.69898749
108histone arginine methylation (GO:0034969)2.69679238
109plasma membrane repair (GO:0001778)2.68309701
110response to muscle activity (GO:0014850)2.60441726
111striated muscle atrophy (GO:0014891)2.59378825
112regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.58868293
113DNA integration (GO:0015074)2.58461169
114DNA dealkylation (GO:0035510)2.58258275
115kinetochore assembly (GO:0051382)2.55989727
116cullin deneddylation (GO:0010388)2.55694004
117nuclear pore organization (GO:0006999)2.54726863
118DNA damage induced protein phosphorylation (GO:0006975)2.54615607
119ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.54390136
120regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.54266201
121replication fork processing (GO:0031297)2.53243492
122negative regulation of potassium ion transmembrane transport (GO:1901380)2.51726105
123striated muscle adaptation (GO:0014888)2.51389708
124striated muscle cell development (GO:0055002)2.50380179
125DNA replication-dependent nucleosome organization (GO:0034723)2.47274824
126DNA replication-dependent nucleosome assembly (GO:0006335)2.47274824
127regulation of double-strand break repair via homologous recombination (GO:0010569)2.47064476
128negative regulation of muscle hypertrophy (GO:0014741)2.46972785
129DNA ligation (GO:0006266)2.44802658
130regulation of sarcomere organization (GO:0060297)2.43549896
131muscle system process (GO:0003012)2.42985587
132viral mRNA export from host cell nucleus (GO:0046784)2.42374781
133mitochondrial DNA metabolic process (GO:0032042)2.42080548
134kinetochore organization (GO:0051383)2.41861264
135maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.41214467
136mitochondrial DNA replication (GO:0006264)2.40980039
137transcription from mitochondrial promoter (GO:0006390)2.40068418
138DNA replication initiation (GO:0006270)2.39049558
139establishment of apical/basal cell polarity (GO:0035089)2.37848903
140muscle cell fate commitment (GO:0042693)2.37764943
141single strand break repair (GO:0000012)2.37517688
142positive regulation of SMAD protein import into nucleus (GO:0060391)2.36941523
143telomere maintenance via semi-conservative replication (GO:0032201)2.36371152
144myotube cell development (GO:0014904)2.35837781
145mitotic metaphase plate congression (GO:0007080)2.35421499
146muscle atrophy (GO:0014889)2.34061441
147regulation of hippo signaling (GO:0035330)2.33985397
148regulation of gene silencing (GO:0060968)2.33417362
149negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.33049397
150DNA replication checkpoint (GO:0000076)2.32125412
151protein K6-linked ubiquitination (GO:0085020)2.31347442
152muscle fiber development (GO:0048747)2.31100949
153regulation of cell communication by electrical coupling (GO:0010649)2.30441863
154muscle cell cellular homeostasis (GO:0046716)2.30120314
155cardiac muscle hypertrophy (GO:0003300)2.29984481
156positive regulation of microtubule polymerization (GO:0031116)2.28932178
157meiotic chromosome segregation (GO:0045132)2.28730004
158positive regulation of DNA-dependent DNA replication (GO:2000105)2.27194307

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.22269742
2EZH2_22144423_ChIP-Seq_EOC_Human4.76438939
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.03835511
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.03835511
5KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.03835511
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.97028587
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.55241248
8BP1_19119308_ChIP-ChIP_Hs578T_Human3.11590541
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.11448746
10E2F4_17652178_ChIP-ChIP_JURKAT_Human3.02530476
11FOXM1_23109430_ChIP-Seq_U2OS_Human3.00099385
12ESR1_20079471_ChIP-ChIP_T-47D_Human2.96771065
13* TBX20_22080862_ChIP-Seq_HEART_Mouse2.95111545
14* TBX20_22328084_ChIP-Seq_HEART_Mouse2.95111545
15CDX2_19796622_ChIP-Seq_MESCs_Mouse2.91360647
16SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.83581769
17ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.78581694
18EP300_21415370_ChIP-Seq_HL-1_Mouse2.74536148
19KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.67209937
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.65212530
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.61183786
22* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.61030416
23MYC_19079543_ChIP-ChIP_MESCs_Mouse2.54866262
24MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.35452362
25PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse2.34887922
26NANOG_18555785_ChIP-Seq_MESCs_Mouse2.34555583
27NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.33510593
28TP63_19390658_ChIP-ChIP_HaCaT_Human2.32961737
29E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.25820371
30MYC_18358816_ChIP-ChIP_MESCs_Mouse2.23721976
31PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.23410462
32SOX2_18555785_ChIP-Seq_MESCs_Mouse2.22859265
33TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.20605372
34POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.18982638
35SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.18144484
36NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.13364991
37ZNF263_19887448_ChIP-Seq_K562_Human2.09602327
38JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.09512330
39KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.07953618
40TCF3_18692474_ChIP-Seq_MESCs_Mouse2.05354275
41SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.04485921
42NELFA_20434984_ChIP-Seq_ESCs_Mouse2.00610380
43EST1_17652178_ChIP-ChIP_JURKAT_Human1.99420286
44HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.98563552
45TCF3_18692474_ChIP-Seq_MEFs_Mouse1.96750221
46POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.92582614
47THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.89712373
48ESR2_21235772_ChIP-Seq_MCF-7_Human1.86226691
49CREB1_15753290_ChIP-ChIP_HEK293T_Human1.83530566
50RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.83175843
51ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.79671781
52ETS1_20019798_ChIP-Seq_JURKAT_Human1.77152861
53HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.76808705
54E2F1_18555785_ChIP-Seq_MESCs_Mouse1.75612625
55RARG_19884340_ChIP-ChIP_MEFs_Mouse1.71954064
56NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.71947060
57SALL1_21062744_ChIP-ChIP_HESCs_Human1.71539730
58STAT3_1855785_ChIP-Seq_MESCs_Mouse1.70241930
59NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.67862808
60THAP11_20581084_ChIP-Seq_MESCs_Mouse1.67627302
61NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.67605742
62YY1_21170310_ChIP-Seq_MESCs_Mouse1.67051814
63ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.66842140
64EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.65098264
65GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.65026405
66ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.64788303
67RBPJ_22232070_ChIP-Seq_NCS_Mouse1.64207842
68* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.61244017
69ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.60355501
70TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.58829931
71YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56572421
72* CTCF_27219007_Chip-Seq_Bcells_Human1.55835458
73MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.55210348
74MYCN_18555785_ChIP-Seq_MESCs_Mouse1.54525767
75POU5F1_16518401_ChIP-PET_MESCs_Mouse1.53195717
76KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.52581653
77GABP_17652178_ChIP-ChIP_JURKAT_Human1.50840703
78NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.49626616
79SRF_21415370_ChIP-Seq_HL-1_Mouse1.44499692
80EZH2_27294783_Chip-Seq_ESCs_Mouse1.43586335
81TRIM28_21343339_ChIP-Seq_HEK293_Human1.42753127
82TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42226979
83EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.36547104
84SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.34426156
85ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.33804704
86POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.33254248
87TTF2_22483619_ChIP-Seq_HELA_Human1.33100598
88STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.32999234
89HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.32899856
90SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.32443720
91SOX2_18692474_ChIP-Seq_MEFs_Mouse1.31970511
92NANOG_18692474_ChIP-Seq_MEFs_Mouse1.31570958
93NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.31469640
94POU5F1_16153702_ChIP-ChIP_HESCs_Human1.30682688
95AR_21572438_ChIP-Seq_LNCaP_Human1.29811318
96NANOG_21062744_ChIP-ChIP_HESCs_Human1.29726821
97SOX2_18692474_ChIP-Seq_MESCs_Mouse1.28876641
98NANOG_16153702_ChIP-ChIP_HESCs_Human1.28284841
99XRN2_22483619_ChIP-Seq_HELA_Human1.27742530
100DROSHA_22980978_ChIP-Seq_HELA_Human1.27205929
101* NFIB_24661679_ChIP-Seq_LUNG_Mouse1.27155672
102NANOG_18692474_ChIP-Seq_MESCs_Mouse1.26682657
103SMC3_22415368_ChIP-Seq_MEFs_Mouse1.23364240
104SOX2_16153702_ChIP-ChIP_HESCs_Human1.22277320
105E2F1_21310950_ChIP-Seq_MCF-7_Human1.21514961
106NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.19723064
107KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.19190134
108GATA4_21415370_ChIP-Seq_HL-1_Mouse1.18775624
109DCP1A_22483619_ChIP-Seq_HELA_Human1.18373569
110CBX2_27304074_Chip-Seq_ESCs_Mouse1.17096164
111CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.16929132
112IGF1R_20145208_ChIP-Seq_DFB_Human1.16405383
113VDR_23849224_ChIP-Seq_CD4+_Human1.15877470
114POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.15695045
115CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.15622088
116TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.15050014
117CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.13659395
118ESR1_21235772_ChIP-Seq_MCF-7_Human1.13238200
119RARB_27405468_Chip-Seq_BRAIN_Mouse1.13226372
120* CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.12380897
121FOXP3_21729870_ChIP-Seq_TREG_Human1.11876409
122EZH2_27304074_Chip-Seq_ESCs_Mouse1.10526104
123HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.09605793
124EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.09001008
125ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.08570705
126TP53_20018659_ChIP-ChIP_R1E_Mouse1.08502548
127ELK1_19687146_ChIP-ChIP_HELA_Human1.08491984
128PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07750059
129ZFP281_18757296_ChIP-ChIP_E14_Mouse1.06981540
130CLOCK_20551151_ChIP-Seq_293T_Human1.05796707
131* MYC_27129775_Chip-Seq_CORNEA_Mouse1.05467488
132JARID2_20075857_ChIP-Seq_MESCs_Mouse1.04717995
133ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.04016935
134MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.03867402
135ERG_21242973_ChIP-ChIP_JURKAT_Human1.03567659
136PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.03380500
137RNF2_18974828_ChIP-Seq_MESCs_Mouse1.01513763
138EZH2_18974828_ChIP-Seq_MESCs_Mouse1.01513763
139CTCF_21964334_ChIP-Seq_BJAB-B_Human1.00040003
140STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.98963766
141OCT4_20526341_ChIP-Seq_ESCs_Human0.98935888
142YY1_22570637_ChIP-Seq_MALME-3M_Human0.97808917
143PPARA_22158963_ChIP-Seq_LIVER_Mouse0.97550795
144MTF2_20144788_ChIP-Seq_MESCs_Mouse0.97438150
145RXR_22158963_ChIP-Seq_LIVER_Mouse0.96300101
146MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.95100323
147OCT4_18692474_ChIP-Seq_MEFs_Mouse0.94685855
148BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.93974150
149ZFX_18555785_ChIP-Seq_MESCs_Mouse0.92369344
150HIF1A_21447827_ChIP-Seq_MCF-7_Human0.92159483
151POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.91084970
152LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.89963469
153TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.89932234
154* SA1_27219007_Chip-Seq_Bcells_Human0.89268881
155FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.89230534
156AR_21909140_ChIP-Seq_LNCAP_Human0.89225828
157* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.89154406
158SMAD3_21741376_ChIP-Seq_HESCs_Human0.88114256
159ELF1_17652178_ChIP-ChIP_JURKAT_Human0.87997331
160CIITA_25753668_ChIP-Seq_RAJI_Human0.87991074
161VDR_22108803_ChIP-Seq_LS180_Human0.87987754
162* ISL1_27105846_Chip-Seq_CPCs_Mouse0.84328510
163MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.83257185
164SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.83138931
165SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.82907238
166FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.82896730
167CTCF_21964334_Chip-Seq_Bcells_Human0.82088975
168LXR_22158963_ChIP-Seq_LIVER_Mouse0.81535625
169RAD21_21589869_ChIP-Seq_MESCs_Mouse0.80397762
170SUZ12_27294783_Chip-Seq_NPCs_Mouse0.80011174
171SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.79978561
172DNAJC2_21179169_ChIP-ChIP_NT2_Human0.79193965
173WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.79127778
174* SPI1_20517297_ChIP-Seq_HL60_Human0.78055951
175KDM2B_26808549_Chip-Seq_DND41_Human0.77805395
176* CRX_20693478_ChIP-Seq_RETINA_Mouse0.76583533
177EGR1_19032775_ChIP-ChIP_M12_Human0.74873703
178RNF2_27304074_Chip-Seq_ESCs_Mouse0.74823634
179SUZ12_27294783_Chip-Seq_ESCs_Mouse0.74788079
180SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.74589809
181SOX2_21211035_ChIP-Seq_LN229_Gbm0.74447080
182GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.74353824
183* GATA1_19941827_ChIP-Seq_MEL_Mouse0.74123546
184STAT1_20625510_ChIP-Seq_HELA_Human0.73964492
185OCT4_21477851_ChIP-Seq_ESCs_Mouse0.72909497
186CTCF_26484167_Chip-Seq_Bcells_Mouse0.72743125
187NRF2_20460467_ChIP-Seq_MEFs_Mouse0.71339723
188NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.71339723

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004145_abnormal_muscle_electrophysio4.75325190
2MP0000749_muscle_degeneration4.42484453
3MP0003646_muscle_fatigue3.86525758
4MP0000751_myopathy3.29520208
5MP0005451_abnormal_body_composition3.13612029
6MP0004036_abnormal_muscle_relaxation2.95534733
7MP0002106_abnormal_muscle_physiology2.88147191
8MP0004084_abnormal_cardiac_muscle2.44645058
9MP0005369_muscle_phenotype2.42958888
10MP0002269_muscular_atrophy2.42025697
11MP0004087_abnormal_muscle_fiber2.36624102
12MP0000759_abnormal_skeletal_muscle2.36326802
13MP0004233_abnormal_muscle_weight2.25163693
14MP0000747_muscle_weakness2.23970060
15MP0008057_abnormal_DNA_replication2.23698709
16MP0000750_abnormal_muscle_regeneration2.18016466
17MP0005620_abnormal_muscle_contractility2.15765825
18MP0010030_abnormal_orbit_morphology2.07117259
19MP0010094_abnormal_chromosome_stability2.06026671
20MP0003941_abnormal_skin_development2.00461668
21MP0005330_cardiomyopathy1.97576049
22MP0004133_heterotaxia1.93142364
23MP0008058_abnormal_DNA_repair1.90488113
24MP0002837_dystrophic_cardiac_calcinosis1.88798366
25MP0003111_abnormal_nucleus_morphology1.78954886
26MP0003567_abnormal_fetal_cardiomyocyte1.75960816
27MP0003950_abnormal_plasma_membrane1.75193253
28MP0004957_abnormal_blastocyst_morpholog1.65210866
29MP0002332_abnormal_exercise_endurance1.62151014
30MP0004510_myositis1.60263881
31MP0000013_abnormal_adipose_tissue1.55215525
32MP0003077_abnormal_cell_cycle1.50781951
33MP0004270_analgesia1.48457524
34MP0010630_abnormal_cardiac_muscle1.47673965
35MP0000762_abnormal_tongue_morphology1.47382072
36MP0003136_yellow_coat_color1.44168948
37MP0003806_abnormal_nucleotide_metabolis1.43633401
38MP0000733_abnormal_muscle_development1.42192031
39MP0002127_abnormal_cardiovascular_syste1.41326126
40MP0003122_maternal_imprinting1.41002218
41MP0003137_abnormal_impulse_conducting1.40977313
42MP0002108_abnormal_muscle_morphology1.38735955
43MP0008932_abnormal_embryonic_tissue1.38479272
44MP0003693_abnormal_embryo_hatching1.37952119
45MP0003121_genomic_imprinting1.37320437
46MP0002972_abnormal_cardiac_muscle1.36107363
47MP0003221_abnormal_cardiomyocyte_apopto1.35887949
48MP0006036_abnormal_mitochondrial_physio1.33768323
49MP0002249_abnormal_larynx_morphology1.30966550
50MP0004215_abnormal_myocardial_fiber1.30766992
51MP0005171_absent_coat_pigmentation1.27556592
52MP0003828_pulmonary_edema1.23915381
53MP0003890_abnormal_embryonic-extraembry1.18238406
54MP0004197_abnormal_fetal_growth/weight/1.17640133
55MP0003123_paternal_imprinting1.14563858
56MP0005380_embryogenesis_phenotype1.14124789
57MP0001672_abnormal_embryogenesis/_devel1.14124789
58MP0003878_abnormal_ear_physiology1.13622759
59MP0005377_hearing/vestibular/ear_phenot1.13622759
60MP0002085_abnormal_embryonic_tissue1.13612763
61MP0001293_anophthalmia1.13382704
62MP0003786_premature_aging1.11080416
63MP0001661_extended_life_span1.10335030
64MP0000566_synostosis1.09988737
65MP0003119_abnormal_digestive_system1.09575570
66MP0001730_embryonic_growth_arrest1.05671466
67MP0002653_abnormal_ependyma_morphology1.05078430
68MP0003984_embryonic_growth_retardation1.04133067
69MP0006292_abnormal_olfactory_placode1.03191903
70MP0002971_abnormal_brown_adipose1.03146970
71MP0003937_abnormal_limbs/digits/tail_de1.02241675
72MP0002088_abnormal_embryonic_growth/wei1.01730301
73MP0008877_abnormal_DNA_methylation1.01552883
74MP0002084_abnormal_developmental_patter0.99824910
75MP0008007_abnormal_cellular_replicative0.99062841
76MP0008775_abnormal_heart_ventricle0.97879921
77MP0002822_catalepsy0.96874258
78MP0005266_abnormal_metabolism0.96283598
79MP0006035_abnormal_mitochondrial_morpho0.95702822
80MP0005385_cardiovascular_system_phenoty0.94859123
81MP0001544_abnormal_cardiovascular_syste0.94859123
82MP0000049_abnormal_middle_ear0.92749968
83MP0001697_abnormal_embryo_size0.92647236
84MP0009250_abnormal_appendicular_skeleto0.90827720
85MP0000266_abnormal_heart_morphology0.88929476
86MP0000350_abnormal_cell_proliferation0.88184316
87MP0005670_abnormal_white_adipose0.88103112
88MP0002114_abnormal_axial_skeleton0.86906309
89MP0005375_adipose_tissue_phenotype0.86576868
90MP0005666_abnormal_adipose_tissue0.84605984
91MP0003755_abnormal_palate_morphology0.84155856
92MP0002932_abnormal_joint_morphology0.83488598
93MP0000537_abnormal_urethra_morphology0.83431433
94MP0000003_abnormal_adipose_tissue0.83277584
95MP0003385_abnormal_body_wall0.82795874
96MP0004085_abnormal_heartbeat0.82751540
97MP0004134_abnormal_chest_morphology0.81927278
98MP0002086_abnormal_extraembryonic_tissu0.81581328
99MP0003283_abnormal_digestive_organ0.81506950
100MP0003315_abnormal_perineum_morphology0.80993559
101MP0000516_abnormal_urinary_system0.79771252
102MP0005367_renal/urinary_system_phenotyp0.79771252
103MP0002111_abnormal_tail_morphology0.79661596
104MP0000432_abnormal_head_morphology0.76452956
105MP0006138_congestive_heart_failure0.75342780
106MP0004130_abnormal_muscle_cell0.73966642
107MP0004484_altered_response_of0.73382918
108MP0000678_abnormal_parathyroid_gland0.73348350
109MP0004185_abnormal_adipocyte_glucose0.72920458
110MP0001286_abnormal_eye_development0.68704682
111MP0003935_abnormal_craniofacial_develop0.68601852
112MP0003045_fibrosis0.68592812
113MP0003879_abnormal_hair_cell0.68291291
114MP0002080_prenatal_lethality0.67464350
115MP0009780_abnormal_chondrocyte_physiolo0.62813651
116MP0004147_increased_porphyrin_level0.57697430
117MP0001299_abnormal_eye_distance/0.57379355
118MP0000372_irregular_coat_pigmentation0.56726203
119MP0009672_abnormal_birth_weight0.50831417
120MP0004043_abnormal_pH_regulation0.47143913
121MP0002128_abnormal_blood_circulation0.44230777
122MP0001346_abnormal_lacrimal_gland0.44004738
123MP0002078_abnormal_glucose_homeostasis0.40097478
124MP0003656_abnormal_erythrocyte_physiolo0.35151080
125MP0002638_abnormal_pupillary_reflex0.35038919
126MP0008569_lethality_at_weaning0.34818488
127MP0003705_abnormal_hypodermis_morpholog0.33413438
128MP0002896_abnormal_bone_mineralization0.33263121
129MP0005584_abnormal_enzyme/coenzyme_acti0.32001266
130MP0003948_abnormal_gas_homeostasis0.30913350
131MP0006276_abnormal_autonomic_nervous0.28243700
132MP0004142_abnormal_muscle_tone0.27705470
133MP0005083_abnormal_biliary_tract0.27085257
134MP0005376_homeostasis/metabolism_phenot0.26793104
135MP0002734_abnormal_mechanical_nocicepti0.26631666
136MP0005165_increased_susceptibility_to0.25954310
137MP0004858_abnormal_nervous_system0.25340191
138MP0005452_abnormal_adipose_tissue0.25267566
139MP0005187_abnormal_penis_morphology0.24873969
140MP0000534_abnormal_ureter_morphology0.24285903
141MP0005167_abnormal_blood-brain_barrier0.24028719
142MP0000230_abnormal_systemic_arterial0.23915146
143MP0005535_abnormal_body_temperature0.23777857
144MP0005319_abnormal_enzyme/_coenzyme0.23340022
145MP0005332_abnormal_amino_acid0.22516861
146MP0005166_decreased_susceptibility_to0.21955126
147MP0001943_abnormal_respiration0.21855168
148MP0005334_abnormal_fat_pad0.19463789
149MP0002066_abnormal_motor_capabilities/c0.17654462
150MP0009703_decreased_birth_body0.17037010
151MP0005423_abnormal_somatic_nervous0.14587043

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)6.94367204
2Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)6.68583180
3Exercise-induced muscle cramps (HP:0003710)6.63588908
4Exercise-induced myalgia (HP:0003738)6.60857538
5Nemaline bodies (HP:0003798)6.31967857
6Muscle hypertrophy of the lower extremities (HP:0008968)5.68121750
7Type 1 muscle fiber predominance (HP:0003803)5.23676951
8Calf muscle hypertrophy (HP:0008981)5.19599732
9Distal arthrogryposis (HP:0005684)4.50918401
10Myopathic facies (HP:0002058)4.30459030
11Muscle fiber splitting (HP:0003555)4.26754859
12Round ear (HP:0100830)4.19584154
13Subaortic stenosis (HP:0001682)4.03780147
14Abnormality of the left ventricular outflow tract (HP:0011103)4.03780147
15Myoglobinuria (HP:0002913)3.91237247
16EMG: myopathic abnormalities (HP:0003458)3.73455485
17Ulnar deviation of the wrist (HP:0003049)3.72386613
18Hyporeflexia of lower limbs (HP:0002600)3.70055872
19Calcaneovalgus deformity (HP:0001848)3.69051962
20Abnormality of the calf musculature (HP:0001430)3.66349946
21Rhabdomyolysis (HP:0003201)3.54297329
22Difficulty running (HP:0009046)3.47005962
23Deformed tarsal bones (HP:0008119)3.33242186
24Sudden death (HP:0001699)3.30534856
25Frequent falls (HP:0002359)3.30063369
26Increased connective tissue (HP:0009025)3.23004279
27Muscle stiffness (HP:0003552)3.22542829
28Rimmed vacuoles (HP:0003805)3.11744963
29Distal lower limb muscle weakness (HP:0009053)3.07221473
30Chromosomal breakage induced by crosslinking agents (HP:0003221)3.04412146
31Ventricular tachycardia (HP:0004756)3.03039255
32Neck muscle weakness (HP:0000467)3.00236630
33Bundle branch block (HP:0011710)2.98529358
34Fetal akinesia sequence (HP:0001989)2.87027981
35Absent phalangeal crease (HP:0006109)2.74829782
36Chromsome breakage (HP:0040012)2.74242992
37Areflexia of lower limbs (HP:0002522)2.69489535
38Myotonia (HP:0002486)2.62427325
39Scapular winging (HP:0003691)2.41457633
40Gowers sign (HP:0003391)2.40890542
41Distal lower limb amyotrophy (HP:0008944)2.39550675
42Abnormality of the neuromuscular junction (HP:0003398)2.39122114
43Fatigable weakness (HP:0003473)2.39122114
44Abnormality of the calcaneus (HP:0008364)2.37437110
45Abnormality of skeletal muscle fiber size (HP:0012084)2.33726946
46Limb-girdle muscle atrophy (HP:0003797)2.31071229
47Malignant hyperthermia (HP:0002047)2.28035262
48Abnormal finger flexion creases (HP:0006143)2.24677692
49Duplicated collecting system (HP:0000081)2.22308325
50Generalized muscle weakness (HP:0003324)2.21189174
51Hypoplastic ischia (HP:0003175)2.18171302
52Pelvic girdle muscle weakness (HP:0003749)2.15651029
53Shoulder girdle muscle weakness (HP:0003547)2.09470082
54EMG: neuropathic changes (HP:0003445)2.09369822
55Lipoatrophy (HP:0100578)2.09319397
56Proximal amyotrophy (HP:0007126)2.07995593
57Abnormality of the musculature of the pelvis (HP:0001469)2.06758550
58Abnormality of the hip-girdle musculature (HP:0001445)2.06758550
59Ependymoma (HP:0002888)2.06702692
60Popliteal pterygium (HP:0009756)2.04303318
61Waddling gait (HP:0002515)2.03895461
62Supernumerary spleens (HP:0009799)2.03353932
63Abnormality of the renal collecting system (HP:0004742)2.01577862
64Paralysis (HP:0003470)2.00672041
65Hyperkalemia (HP:0002153)1.98569893
66Increased variability in muscle fiber diameter (HP:0003557)1.98537524
67Abnormality of the foot musculature (HP:0001436)1.98342673
68Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.98319305
69Dilated cardiomyopathy (HP:0001644)1.96781877
70Difficulty climbing stairs (HP:0003551)1.96479099
71Abnormality of the shoulder girdle musculature (HP:0001435)1.94561957
72Heart block (HP:0012722)1.94070905
73Rectal fistula (HP:0100590)1.92634441
74Rectovaginal fistula (HP:0000143)1.92634441
75Progressive muscle weakness (HP:0003323)1.92284293
76Exercise intolerance (HP:0003546)1.91324796
77Metatarsus adductus (HP:0001840)1.90899604
78Abnormality of the ileum (HP:0001549)1.90878380
79Maternal diabetes (HP:0009800)1.89157268
80Long clavicles (HP:0000890)1.87791452
81Mildly elevated creatine phosphokinase (HP:0008180)1.87202051
82Centrally nucleated skeletal muscle fibers (HP:0003687)1.84276664
83Meckel diverticulum (HP:0002245)1.83150093
84Foot dorsiflexor weakness (HP:0009027)1.82681467
85Asymmetric septal hypertrophy (HP:0001670)1.82376018
86Abnormal atrioventricular conduction (HP:0005150)1.81752121
87Muscular dystrophy (HP:0003560)1.81530086
88Abnormality of glycolysis (HP:0004366)1.80799089
89Increased serum pyruvate (HP:0003542)1.80799089
90Embryonal renal neoplasm (HP:0011794)1.80685723
91Rib fusion (HP:0000902)1.80389587
92Lower limb amyotrophy (HP:0007210)1.80014272
93Abnormality of the ischium (HP:0003174)1.79277922
94Hip contracture (HP:0003273)1.79079301
95Nephroblastoma (Wilms tumor) (HP:0002667)1.78550920
96Respiratory insufficiency due to muscle weakness (HP:0002747)1.78407550
97Slender build (HP:0001533)1.77593651
98Atrial fibrillation (HP:0005110)1.75068261
99Absent radius (HP:0003974)1.73216936
100Ventricular arrhythmia (HP:0004308)1.71903592
101Ragged-red muscle fibers (HP:0003200)1.71793800
102Aplasia/Hypoplasia of the uvula (HP:0010293)1.70392303
103Intestinal atresia (HP:0011100)1.70221507
104Nonprogressive disorder (HP:0003680)1.69527266
105Limb-girdle muscle weakness (HP:0003325)1.69263013
106Bulbar palsy (HP:0001283)1.68031930
107Limited hip movement (HP:0008800)1.67700768
108Ulnar deviation of finger (HP:0009465)1.67626121
109Bilateral microphthalmos (HP:0007633)1.65787937
110Breech presentation (HP:0001623)1.65263462
111Weak cry (HP:0001612)1.64161140
112Type 2 muscle fiber atrophy (HP:0003554)1.63572300
113Abnormality of the pubic bones (HP:0003172)1.62871553
114Spinal rigidity (HP:0003306)1.61951998
115Intestinal fistula (HP:0100819)1.61141579
116Periauricular skin pits (HP:0100277)1.60369454
117Preauricular pit (HP:0004467)1.60369454
118Aplasia/hypoplasia of the humerus (HP:0006507)1.59935520
119Primary atrial arrhythmia (HP:0001692)1.59496331
120Aplasia involving forearm bones (HP:0009822)1.57630137
121Absent forearm bone (HP:0003953)1.57630137
122Facial diplegia (HP:0001349)1.56862742
123Supraventricular tachycardia (HP:0004755)1.56767514
124Medulloblastoma (HP:0002885)1.56060745
125Bell-shaped thorax (HP:0001591)1.55527450
126Patellar aplasia (HP:0006443)1.54565649
127Abnormality of the labia minora (HP:0012880)1.54223595
128Muscle fiber atrophy (HP:0100295)1.51625039
129Abnormality of placental membranes (HP:0011409)1.41410434
130Amniotic constriction ring (HP:0009775)1.41410434
131Increased intramyocellular lipid droplets (HP:0012240)1.40069866
132Ulnar deviation of the hand or of fingers of the hand (HP:0001193)1.38335062
133Steppage gait (HP:0003376)1.34919991
134Adducted thumb (HP:0001181)1.32452774
135Oligomenorrhea (HP:0000876)1.29214604
136Increased muscle lipid content (HP:0009058)1.28922547
137Abnormality of potassium homeostasis (HP:0011042)1.27507284

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN7.12987175
2ZAK3.65557771
3PHKG13.57734686
4PHKG23.57734686
5TTN3.17512482
6NME12.50103546
7STK38L2.35707468
8TTK2.27251206
9NEK12.24119161
10CDK121.96522978
11PINK11.85411832
12AKT31.84470546
13PIK3CG1.56782078
14TLK11.53428367
15SRPK11.52329677
16BUB11.52162238
17DMPK1.49368571
18EPHA21.42410505
19PLK41.40162161
20PDK31.35519919
21PDK41.35519919
22EEF2K1.29655306
23STK241.28368445
24WEE11.27986375
25MAP2K41.19179775
26PLK11.15298063
27CDK71.12159655
28MAP2K31.10461046
29PIK3CA1.09895646
30MKNK11.09432150
31BCKDK1.09229851
32PDK21.08344323
33EIF2AK11.05088363
34CHEK21.03345800
35STK41.02717255
36CDC71.02097573
37RPS6KB21.01130121
38VRK10.99747653
39MARK10.99641694
40DYRK30.95784922
41ATR0.91265556
42TAOK20.90652654
43MKNK20.90541927
44ERBB30.89993202
45MOS0.87355301
46TIE10.84985758
47MAP3K70.84824972
48YES10.82317842
49TRIB30.80220788
50CCNB10.80218692
51AKT20.78931386
52PLK30.78800271
53DYRK20.78070035
54BCR0.77484047
55DYRK1B0.76184723
56PKN10.75052214
57EIF2AK20.74883096
58CLK10.73931115
59MYLK0.73630656
60AURKB0.73519051
61TRPM70.71499093
62MAPK150.69778082
63RIPK10.68828288
64CHEK10.68794532
65ICK0.65775361
66CAMK40.65524042
67MAPK120.63877101
68PASK0.63654502
69AURKA0.62847233
70PRPF4B0.61235705
71DDR20.60564290
72PRKAA10.58946920
73NEK90.58265576
74ATM0.57941540
75CDK40.57313585
76MAPK70.56740403
77LIMK10.56065961
78MAPKAPK30.55842241
79STK390.54574326
80MAP3K100.51624444
81UHMK10.50896866
82CDC42BPA0.50799366
83CAMK2D0.50767007
84MAP2K60.50423755
85MAP3K30.50313153
86PRKG10.48899480
87MAP2K10.48686889
88NEK20.47882758
89RPS6KA50.46942187
90CDK20.45995512
91MAPK40.45507620
92MAPK110.45045928
93MAP3K130.44197919
94SGK30.44172892
95PRKAA20.43310983
96CAMK10.43092413
97GRK10.42888930
98PRKCI0.42396785
99FLT30.42131233
100CAMK2A0.41526147
101CSNK2A10.41130499
102MUSK0.40061457
103CAMK2B0.39907547
104MAP3K110.39641134
105LATS20.39064697
106KSR20.38482113
107ROCK10.38454752
108CDK10.38212542
109IRAK30.37776648
110PBK0.37743786
111LATS10.37365739
112BRD40.37349553
113MAP3K80.36101038
114CSNK1D0.35698668
115STK30.35517527
116NEK60.34684036
117PRKDC0.34171721
118WNK10.33329494
119SGK20.32285050
120WNK40.31648337
121PRKACA0.31083510
122MTOR0.29967735
123PAK40.29427314
124CAMK2G0.28986357
125RPS6KB10.28287652
126NLK0.27503347
127RPS6KA30.24977938
128MAP3K10.24852149
129SIK10.22581746
130PDPK10.22549129
131SGK10.22472674
132CDK190.21442783
133PRKACB0.21327847
134MARK20.21314868
135MAPK100.21155244
136PKN20.20626756
137RPS6KA10.19959981
138OXSR10.19651323
139SGK2230.18377748
140SGK4940.18377748
141RPS6KC10.17576705
142RPS6KL10.17576705
143PRKD10.17135554
144TBK10.16352728
145EPHB10.15918579
146DAPK20.15703503
147MAP2K20.15584455
148RPS6KA60.12978510
149MAPK130.11788055
150PDK10.11479219
151PRKACG0.10645744
152MAP3K60.10356523
153ARAF0.09920588
154EPHA30.09808709
155RPS6KA20.08358217
156STK110.08281460
157STK380.03835341
158GSK3B0.02245945
159MAPK80.01993782
160MARK30.00988100
161MAPK90.00854185

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.98953051
2Mismatch repair_Homo sapiens_hsa034303.43475810
3DNA replication_Homo sapiens_hsa030302.89477383
4Homologous recombination_Homo sapiens_hsa034402.82087930
5Cardiac muscle contraction_Homo sapiens_hsa042602.70695582
6Fanconi anemia pathway_Homo sapiens_hsa034602.66094404
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.60529133
8Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.56728315
9Base excision repair_Homo sapiens_hsa034102.51144407
10RNA polymerase_Homo sapiens_hsa030202.45064124
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.22620453
12Spliceosome_Homo sapiens_hsa030402.18651550
13RNA transport_Homo sapiens_hsa030132.17194994
14Parkinsons disease_Homo sapiens_hsa050122.14980937
15Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.14336524
16Nucleotide excision repair_Homo sapiens_hsa034202.03944165
17Oxidative phosphorylation_Homo sapiens_hsa001901.97301909
18Proteasome_Homo sapiens_hsa030501.97290021
19Dilated cardiomyopathy_Homo sapiens_hsa054141.96921531
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.94180544
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.89941678
22RNA degradation_Homo sapiens_hsa030181.89584249
23mRNA surveillance pathway_Homo sapiens_hsa030151.75013378
24Cell cycle_Homo sapiens_hsa041101.74795969
25Non-homologous end-joining_Homo sapiens_hsa034501.74681086
26One carbon pool by folate_Homo sapiens_hsa006701.74022936
27Calcium signaling pathway_Homo sapiens_hsa040201.73939568
28Arginine biosynthesis_Homo sapiens_hsa002201.70956210
29Huntingtons disease_Homo sapiens_hsa050161.68907175
30Ribosome_Homo sapiens_hsa030101.65908304
31Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.63451596
32Basal transcription factors_Homo sapiens_hsa030221.60150232
33Insulin resistance_Homo sapiens_hsa049311.55706667
34Tight junction_Homo sapiens_hsa045301.51234650
35Basal cell carcinoma_Homo sapiens_hsa052171.44786846
36Pyrimidine metabolism_Homo sapiens_hsa002401.39034835
37Alzheimers disease_Homo sapiens_hsa050101.27919299
38Carbon metabolism_Homo sapiens_hsa012001.22576605
39Hippo signaling pathway_Homo sapiens_hsa043901.22351356
40Arginine and proline metabolism_Homo sapiens_hsa003301.18080704
41Fatty acid degradation_Homo sapiens_hsa000711.17902421
42Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.17562684
43Purine metabolism_Homo sapiens_hsa002301.17242929
44Biosynthesis of amino acids_Homo sapiens_hsa012301.12732165
45Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.12092336
46Adipocytokine signaling pathway_Homo sapiens_hsa049201.10991176
47Fructose and mannose metabolism_Homo sapiens_hsa000511.07933199
48Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.06912457
49p53 signaling pathway_Homo sapiens_hsa041151.04966761
50Galactose metabolism_Homo sapiens_hsa000521.03794472
51Hedgehog signaling pathway_Homo sapiens_hsa043401.02682178
52Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.02560337
53Vascular smooth muscle contraction_Homo sapiens_hsa042701.01734217
54Viral myocarditis_Homo sapiens_hsa054161.00946546
55Adherens junction_Homo sapiens_hsa045201.00595524
56Circadian rhythm_Homo sapiens_hsa047100.99162114
57Gastric acid secretion_Homo sapiens_hsa049710.98900901
58Nitrogen metabolism_Homo sapiens_hsa009100.98558923
59Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.96940877
60Phenylalanine metabolism_Homo sapiens_hsa003600.93084242
61Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.91987416
62Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.90783485
63Arachidonic acid metabolism_Homo sapiens_hsa005900.89817468
64Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.87555447
65Notch signaling pathway_Homo sapiens_hsa043300.86671832
66Propanoate metabolism_Homo sapiens_hsa006400.84806236
67Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.81115620
68Renin secretion_Homo sapiens_hsa049240.79133490
69Systemic lupus erythematosus_Homo sapiens_hsa053220.77027085
70Starch and sucrose metabolism_Homo sapiens_hsa005000.76890651
71TGF-beta signaling pathway_Homo sapiens_hsa043500.74111863
72GnRH signaling pathway_Homo sapiens_hsa049120.74043681
73Fatty acid metabolism_Homo sapiens_hsa012120.71386587
74Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.69829327
75Long-term potentiation_Homo sapiens_hsa047200.67279859
76Linoleic acid metabolism_Homo sapiens_hsa005910.66392043
77Wnt signaling pathway_Homo sapiens_hsa043100.66021679
78Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65301418
79Fatty acid elongation_Homo sapiens_hsa000620.64968278
80Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63310687
81Epstein-Barr virus infection_Homo sapiens_hsa051690.61398790
82Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.61265651
83Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.56925884
84Glucagon signaling pathway_Homo sapiens_hsa049220.56261221
85Pyruvate metabolism_Homo sapiens_hsa006200.54308019
86Insulin secretion_Homo sapiens_hsa049110.51092449
87Insulin signaling pathway_Homo sapiens_hsa049100.51047952
88MicroRNAs in cancer_Homo sapiens_hsa052060.49952686
89Transcriptional misregulation in cancer_Homo sapiens_hsa052020.49806878
90alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.47394946
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47118416
92AMPK signaling pathway_Homo sapiens_hsa041520.46784589
93beta-Alanine metabolism_Homo sapiens_hsa004100.46695239
94Circadian entrainment_Homo sapiens_hsa047130.46518668
95Vitamin B6 metabolism_Homo sapiens_hsa007500.46407507
96Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.46284023
97HTLV-I infection_Homo sapiens_hsa051660.46248565
98HIF-1 signaling pathway_Homo sapiens_hsa040660.45378026
99Aldosterone synthesis and secretion_Homo sapiens_hsa049250.44235413
100Viral carcinogenesis_Homo sapiens_hsa052030.43981174
101Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.43856247
102Oocyte meiosis_Homo sapiens_hsa041140.43804718
103Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.42745090
104Metabolic pathways_Homo sapiens_hsa011000.42005972
105Regulation of actin cytoskeleton_Homo sapiens_hsa048100.41268523
106Pathways in cancer_Homo sapiens_hsa052000.41144688
107Focal adhesion_Homo sapiens_hsa045100.40450734
108Herpes simplex infection_Homo sapiens_hsa051680.40205174
109Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.39299759
110Salivary secretion_Homo sapiens_hsa049700.39054891
111PPAR signaling pathway_Homo sapiens_hsa033200.38600957
112Butanoate metabolism_Homo sapiens_hsa006500.38579076
113Ether lipid metabolism_Homo sapiens_hsa005650.38466539
114MAPK signaling pathway_Homo sapiens_hsa040100.38113742
115Glutathione metabolism_Homo sapiens_hsa004800.35483422
116Lysine degradation_Homo sapiens_hsa003100.35220923
117Pentose phosphate pathway_Homo sapiens_hsa000300.34620420
118Protein export_Homo sapiens_hsa030600.34461396
119Melanogenesis_Homo sapiens_hsa049160.32884772
120Long-term depression_Homo sapiens_hsa047300.32135701
121cAMP signaling pathway_Homo sapiens_hsa040240.31706965
122Amoebiasis_Homo sapiens_hsa051460.30194507
123Peroxisome_Homo sapiens_hsa041460.30092555
124Tryptophan metabolism_Homo sapiens_hsa003800.29669131
125Central carbon metabolism in cancer_Homo sapiens_hsa052300.28855458
126VEGF signaling pathway_Homo sapiens_hsa043700.28569752
127Histidine metabolism_Homo sapiens_hsa003400.28197833
128Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.27791708
129Cysteine and methionine metabolism_Homo sapiens_hsa002700.27706143
130Steroid biosynthesis_Homo sapiens_hsa001000.27596889
131Cholinergic synapse_Homo sapiens_hsa047250.26813106
132mTOR signaling pathway_Homo sapiens_hsa041500.25178008
133Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.25046350
134cGMP-PKG signaling pathway_Homo sapiens_hsa040220.24878931
135FoxO signaling pathway_Homo sapiens_hsa040680.24813093
136Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.24568314
137ECM-receptor interaction_Homo sapiens_hsa045120.24493890
138Sulfur relay system_Homo sapiens_hsa041220.23672556
139Glioma_Homo sapiens_hsa052140.22663071
140Oxytocin signaling pathway_Homo sapiens_hsa049210.22457764
141Thyroid cancer_Homo sapiens_hsa052160.22445560
142PI3K-Akt signaling pathway_Homo sapiens_hsa041510.22024408
143Autoimmune thyroid disease_Homo sapiens_hsa053200.21430456
144Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.21159186
145Regulation of autophagy_Homo sapiens_hsa041400.18858356
146Amphetamine addiction_Homo sapiens_hsa050310.17865552
147Tyrosine metabolism_Homo sapiens_hsa003500.16575072
148Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.16090904
149Ovarian steroidogenesis_Homo sapiens_hsa049130.13364851
150Platelet activation_Homo sapiens_hsa046110.13355417
151Pancreatic secretion_Homo sapiens_hsa049720.12576129
152Bile secretion_Homo sapiens_hsa049760.11884100
153Endometrial cancer_Homo sapiens_hsa052130.11397798
154Leukocyte transendothelial migration_Homo sapiens_hsa046700.11327694

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