SMU1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)5.72785293
2mitotic metaphase plate congression (GO:0007080)4.57948728
3nucleobase biosynthetic process (GO:0046112)4.45014586
4purine nucleobase biosynthetic process (GO:0009113)4.41794777
5DNA strand elongation involved in DNA replication (GO:0006271)4.36046091
6negative regulation of DNA-dependent DNA replication (GO:2000104)4.30959279
7DNA strand elongation (GO:0022616)4.18321855
8DNA replication initiation (GO:0006270)4.17810081
9formation of translation preinitiation complex (GO:0001731)4.15376658
10CENP-A containing nucleosome assembly (GO:0034080)4.12618139
11telomere maintenance via semi-conservative replication (GO:0032201)4.11428451
12protein localization to kinetochore (GO:0034501)4.10722067
13cullin deneddylation (GO:0010388)4.06961703
14non-recombinational repair (GO:0000726)4.05304497
15double-strand break repair via nonhomologous end joining (GO:0006303)4.05304497
16chromatin remodeling at centromere (GO:0031055)4.03730612
17metaphase plate congression (GO:0051310)4.01649957
18ribosomal small subunit assembly (GO:0000028)4.01309516
19RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.97808995
20DNA replication checkpoint (GO:0000076)3.97687729
21maturation of SSU-rRNA (GO:0030490)3.91504132
22IMP biosynthetic process (GO:0006188)3.89830932
23mitotic nuclear envelope disassembly (GO:0007077)3.87620737
24attachment of spindle microtubules to kinetochore (GO:0008608)3.83857095
25telomere maintenance via recombination (GO:0000722)3.82192519
26replication fork processing (GO:0031297)3.81221276
27ribosome biogenesis (GO:0042254)3.78765980
28histone H2A acetylation (GO:0043968)3.74049134
29ribosome assembly (GO:0042255)3.70930457
30establishment of chromosome localization (GO:0051303)3.69343059
31anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.67651579
32DNA replication-independent nucleosome assembly (GO:0006336)3.65333340
33DNA replication-independent nucleosome organization (GO:0034724)3.65333340
34regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.64639322
35negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.64076364
36mitotic recombination (GO:0006312)3.63600694
37DNA deamination (GO:0045006)3.62276009
38regulation of spindle organization (GO:0090224)3.60758809
39protein localization to chromosome, centromeric region (GO:0071459)3.58976255
40DNA catabolic process, exonucleolytic (GO:0000738)3.58085535
41somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.57105204
42somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.57105204
43isotype switching (GO:0045190)3.57105204
44DNA unwinding involved in DNA replication (GO:0006268)3.56716208
45positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.55786614
46nuclear envelope disassembly (GO:0051081)3.55765210
47membrane disassembly (GO:0030397)3.55765210
48kinetochore organization (GO:0051383)3.53033715
49proteasome assembly (GO:0043248)3.52037676
50IMP metabolic process (GO:0046040)3.51889864
51maturation of 5.8S rRNA (GO:0000460)3.51200197
52nuclear pore organization (GO:0006999)3.49738244
53recombinational repair (GO:0000725)3.48946400
54folic acid-containing compound biosynthetic process (GO:0009396)3.48843163
55double-strand break repair via homologous recombination (GO:0000724)3.46877657
56respiratory chain complex IV assembly (GO:0008535)3.45284027
57ribosomal large subunit biogenesis (GO:0042273)3.43287436
58positive regulation of mitotic sister chromatid separation (GO:1901970)3.42120502
59positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.42120502
60positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.42120502
61ribonucleoprotein complex biogenesis (GO:0022613)3.40718837
62telomere maintenance via telomere lengthening (GO:0010833)3.39340051
63DNA replication-dependent nucleosome assembly (GO:0006335)3.38140533
64DNA replication-dependent nucleosome organization (GO:0034723)3.38140533
65histone exchange (GO:0043486)3.36769516
66maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.35289642
67protein prenylation (GO:0018342)3.31855461
68prenylation (GO:0097354)3.31855461
69mitotic sister chromatid segregation (GO:0000070)3.31218664
70response to X-ray (GO:0010165)3.30048297
71mitotic chromosome condensation (GO:0007076)3.28991942
72kinetochore assembly (GO:0051382)3.28093402
73regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.28013194
74exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.27301709
75spliceosomal snRNP assembly (GO:0000387)3.26913115
76negative regulation of ligase activity (GO:0051352)3.25599304
77negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.25599304
78negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.24926499
79postreplication repair (GO:0006301)3.23784615
80rRNA modification (GO:0000154)3.22925383
81negative regulation of mitotic sister chromatid separation (GO:2000816)3.22836212
82negative regulation of mitotic sister chromatid segregation (GO:0033048)3.22836212
83negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.22836212
84negative regulation of sister chromatid segregation (GO:0033046)3.22836212
85regulation of nuclear cell cycle DNA replication (GO:0033262)3.20995634
86negative regulation of chromosome segregation (GO:0051985)3.20569897
87nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.20568601
88spindle checkpoint (GO:0031577)3.20076714
89rRNA processing (GO:0006364)3.17721839
90regulation of mitotic spindle checkpoint (GO:1903504)3.17060992
91regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.17060992
92mitotic spindle assembly checkpoint (GO:0007094)3.15835377
93nucleotide-excision repair, DNA gap filling (GO:0006297)3.15049727
94spindle assembly checkpoint (GO:0071173)3.15011918
95positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.14654171
96transcription-coupled nucleotide-excision repair (GO:0006283)3.14188673
97regulation of mitotic spindle organization (GO:0060236)3.13726647
98regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.13545518
99cell cycle G1/S phase transition (GO:0044843)3.12906387
100G1/S transition of mitotic cell cycle (GO:0000082)3.12906387
101regulation of mitotic metaphase/anaphase transition (GO:0030071)3.11676670
102nuclear pore complex assembly (GO:0051292)3.11016240
103meiotic chromosome segregation (GO:0045132)3.08746014
104regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.08476470
105cytochrome complex assembly (GO:0017004)3.07722911
106rRNA metabolic process (GO:0016072)3.07564327
107branched-chain amino acid catabolic process (GO:0009083)3.07212361
108adenosine metabolic process (GO:0046085)3.06622980
109synapsis (GO:0007129)3.06529865
110protein deneddylation (GO:0000338)3.05643608
111water-soluble vitamin biosynthetic process (GO:0042364)3.05251225
1127-methylguanosine mRNA capping (GO:0006370)3.05221552
113mitotic spindle checkpoint (GO:0071174)3.04294288
114DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.03469550
115positive regulation of chromosome segregation (GO:0051984)3.01839629
116regulation of chromosome segregation (GO:0051983)3.01645507
117DNA ligation (GO:0006266)3.01534935
118rRNA methylation (GO:0031167)3.01426167
119regulation of centriole replication (GO:0046599)3.00754373
120viral mRNA export from host cell nucleus (GO:0046784)3.00145268
121RNA capping (GO:0036260)2.99902254
1227-methylguanosine RNA capping (GO:0009452)2.99902254
123signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.99682826
124intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.99682826
125somatic diversification of immune receptors via somatic mutation (GO:0002566)2.99451490
126somatic hypermutation of immunoglobulin genes (GO:0016446)2.99451490
127signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.99238477
128signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.99238477
129signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.99238477
130positive regulation of ligase activity (GO:0051351)2.98925528
131L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.98747724
132protein K6-linked ubiquitination (GO:0085020)2.98543589
133kynurenine metabolic process (GO:0070189)2.97463654
134lactate metabolic process (GO:0006089)2.96491928
135signal transduction involved in DNA integrity checkpoint (GO:0072401)2.95545451
136signal transduction involved in DNA damage checkpoint (GO:0072422)2.95545451
137protein K11-linked deubiquitination (GO:0035871)2.95493399
138folic acid metabolic process (GO:0046655)2.95065372
139sister chromatid segregation (GO:0000819)2.94949964
140regulation of mitotic sister chromatid segregation (GO:0033047)2.93881368
141double-strand break repair (GO:0006302)2.93158419
142mitochondrial RNA metabolic process (GO:0000959)2.89995117
143regulation of DNA endoreduplication (GO:0032875)2.89944128
144mitochondrial DNA replication (GO:0006264)2.89182973
145DNA strand renaturation (GO:0000733)2.84152097
146response to pheromone (GO:0019236)2.83749009
147regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.81723769
148keratinocyte development (GO:0003334)2.78851846
149indole-containing compound catabolic process (GO:0042436)2.78535876
150indolalkylamine catabolic process (GO:0046218)2.78535876
151tryptophan catabolic process (GO:0006569)2.78535876
152negative regulation of DNA recombination (GO:0045910)2.78323337
153tryptophan metabolic process (GO:0006568)2.74951399
154DNA-dependent DNA replication (GO:0006261)2.74878229
155somatic diversification of immunoglobulins (GO:0016445)2.72902186
156pseudouridine synthesis (GO:0001522)2.72806155
157UDP-N-acetylglucosamine metabolic process (GO:0006047)2.72328259
158regulation of sulfur metabolic process (GO:0042762)2.72153798
159positive regulation of histone H3-K4 methylation (GO:0051571)2.71409755
160rRNA catabolic process (GO:0016075)2.71004425
161histone mRNA catabolic process (GO:0071044)2.70744032
162somatic recombination of immunoglobulin gene segments (GO:0016447)2.68177966
163platelet dense granule organization (GO:0060155)2.66487102
164regulation of acyl-CoA biosynthetic process (GO:0050812)2.65301858
165DNA recombination (GO:0006310)2.64653999
166peptidyl-histidine modification (GO:0018202)2.61747101
167inositol phosphate catabolic process (GO:0071545)2.60505642
168resolution of meiotic recombination intermediates (GO:0000712)2.57462128
169histone mRNA metabolic process (GO:0008334)2.51704210
170ribonucleoprotein complex disassembly (GO:0032988)2.51568573
171L-fucose catabolic process (GO:0042355)2.51186359
172L-fucose metabolic process (GO:0042354)2.51186359

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.67418071
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.19436738
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.70759812
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.60712505
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.53936664
6* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.52279068
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.25573716
8* GABP_17652178_ChIP-ChIP_JURKAT_Human3.19782075
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.15991492
10* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.08930348
11ZNF274_21170338_ChIP-Seq_K562_Hela2.97752320
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.90349574
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.85790397
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.82105156
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.79903658
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.78784140
17POU3F2_20337985_ChIP-ChIP_501MEL_Human2.50990374
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.50321289
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.45356881
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.44840074
21FUS_26573619_Chip-Seq_HEK293_Human2.43318387
22VDR_23849224_ChIP-Seq_CD4+_Human2.43114509
23EWS_26573619_Chip-Seq_HEK293_Human2.42799493
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.39039441
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.35769178
26FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.25004776
27CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.23898953
28MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.23638592
29XRN2_22483619_ChIP-Seq_HELA_Human2.23444411
30E2F1_18555785_ChIP-Seq_MESCs_Mouse2.20280826
31FLI1_27457419_Chip-Seq_LIVER_Mouse2.19766922
32ZFP57_27257070_Chip-Seq_ESCs_Mouse2.19063063
33AR_21909140_ChIP-Seq_LNCAP_Human2.14911175
34ELF1_17652178_ChIP-ChIP_JURKAT_Human2.09479524
35DCP1A_22483619_ChIP-Seq_HELA_Human2.06441926
36IGF1R_20145208_ChIP-Seq_DFB_Human2.04892876
37FOXP3_21729870_ChIP-Seq_TREG_Human2.04273873
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.01396188
39VDR_22108803_ChIP-Seq_LS180_Human2.01278141
40E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.00288742
41GABP_19822575_ChIP-Seq_HepG2_Human1.97902728
42MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.96364902
43HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.96057006
44TAF15_26573619_Chip-Seq_HEK293_Human1.93231190
45E2F1_21310950_ChIP-Seq_MCF-7_Human1.88219094
46* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.88154454
47GBX2_23144817_ChIP-Seq_PC3_Human1.87882899
48MYCN_18555785_ChIP-Seq_MESCs_Mouse1.86679248
49ELK1_19687146_ChIP-ChIP_HELA_Human1.85319958
50P300_19829295_ChIP-Seq_ESCs_Human1.83844077
51POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.82790252
52FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.80333014
53THAP11_20581084_ChIP-Seq_MESCs_Mouse1.79396566
54EGR1_19374776_ChIP-ChIP_THP-1_Human1.78331940
55HOXB4_20404135_ChIP-ChIP_EML_Mouse1.75356004
56TTF2_22483619_ChIP-Seq_HELA_Human1.74748648
57* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.74625494
58NANOG_18555785_ChIP-Seq_MESCs_Mouse1.73214797
59SRF_21415370_ChIP-Seq_HL-1_Mouse1.69546965
60PCGF2_27294783_Chip-Seq_ESCs_Mouse1.64651121
61YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.63389830
62YY1_21170310_ChIP-Seq_MESCs_Mouse1.59079654
63AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.58536080
64* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.58364135
65TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.53940346
66GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48472728
67FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.46395046
68CIITA_25753668_ChIP-Seq_RAJI_Human1.46248859
69ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.44233031
70KDM5A_27292631_Chip-Seq_BREAST_Human1.43288695
71PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.40603577
72POU5F1_16153702_ChIP-ChIP_HESCs_Human1.38474836
73SUZ12_27294783_Chip-Seq_NPCs_Mouse1.37522172
74MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.37331236
75SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.36934847
76ERG_20887958_ChIP-Seq_HPC-7_Mouse1.35513754
77EZH2_27294783_Chip-Seq_NPCs_Mouse1.35184383
78ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.34573359
79CBP_20019798_ChIP-Seq_JUKART_Human1.34468544
80IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.34468544
81EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.34305512
82CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.33878482
83ER_23166858_ChIP-Seq_MCF-7_Human1.33476452
84RBPJ_22232070_ChIP-Seq_NCS_Mouse1.32999774
85PADI4_21655091_ChIP-ChIP_MCF-7_Human1.29646548
86SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.28484584
87CTBP2_25329375_ChIP-Seq_LNCAP_Human1.27800897
88NFE2_27457419_Chip-Seq_LIVER_Mouse1.26131451
89SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25941103
90CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.25925164
91CTBP1_25329375_ChIP-Seq_LNCAP_Human1.25572062
92POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.25383324
93BCAT_22108803_ChIP-Seq_LS180_Human1.23795411
94OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22768836
95RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.22312741
96POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.21246020
97STAT3_1855785_ChIP-Seq_MESCs_Mouse1.20036625
98MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19752481
99TFEB_21752829_ChIP-Seq_HELA_Human1.18526582
100SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.18426305
101PCGF2_27294783_Chip-Seq_NPCs_Mouse1.16770818
102HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.15259064
103NANOG_19829295_ChIP-Seq_ESCs_Human1.14719528
104SOX2_19829295_ChIP-Seq_ESCs_Human1.14719528
105SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.14355917
106E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.12810216
107KLF4_18555785_ChIP-Seq_MESCs_Mouse1.12536028
108MYC_22102868_ChIP-Seq_BL_Human1.12413466
109TP53_22573176_ChIP-Seq_HFKS_Human1.12364605
110MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.11976673
111PIAS1_25552417_ChIP-Seq_VCAP_Human1.11958916
112UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10091752
113SMAD4_21799915_ChIP-Seq_A2780_Human1.10079655
114SOX2_18555785_ChIP-Seq_MESCs_Mouse1.10079289
115NANOG_18555785_Chip-Seq_ESCs_Mouse1.09893750
116TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09582640
117CRX_20693478_ChIP-Seq_RETINA_Mouse1.09474404
118* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.08527721
119SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07271142
120CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06666361
121NOTCH1_21737748_ChIP-Seq_TLL_Human1.05702954
122GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05379881
123MYC_18940864_ChIP-ChIP_HL60_Human1.05251963
124EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03932026
125SMAD3_21741376_ChIP-Seq_EPCs_Human1.03371860
126* CDX2_22108803_ChIP-Seq_LS180_Human1.02923469
127STAT3_23295773_ChIP-Seq_U87_Human1.02454208
128TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00945942
129ELK1_22589737_ChIP-Seq_MCF10A_Human1.00492528
130SPI1_23547873_ChIP-Seq_NB4_Human0.99611480
131P300_18555785_Chip-Seq_ESCs_Mouse0.99571629
132SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.99333002
133KLF5_20875108_ChIP-Seq_MESCs_Mouse0.98959198
134BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.98669534
135P53_22387025_ChIP-Seq_ESCs_Mouse0.98411171
136TCF4_22108803_ChIP-Seq_LS180_Human0.97965502
137SUZ12_18555785_Chip-Seq_ESCs_Mouse0.96950283
138IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.96876881
139AR_25329375_ChIP-Seq_VCAP_Human0.96150933
140NANOG_16153702_ChIP-ChIP_HESCs_Human0.95895939
141CMYC_18555785_Chip-Seq_ESCs_Mouse0.92852204
142SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.92684712
143GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.92525965
144CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.92257918
145CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.92220214
146TCF4_23295773_ChIP-Seq_U87_Human0.91899156
147TP63_19390658_ChIP-ChIP_HaCaT_Human0.90638956
148CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.89940817
149DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.89213502
150* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.88762625
151* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.88481671
152* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.84707080
153HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.81745732
154NANOG_21062744_ChIP-ChIP_HESCs_Human0.80854321
155* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.78420018
156KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.76809143
157NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.76801032
158SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.76400488
159SALL1_21062744_ChIP-ChIP_HESCs_Human0.75161746
160TCF3_18692474_ChIP-Seq_MEFs_Mouse0.74687867
161TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.74491595
162CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.74191831

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.71483646
2MP0010094_abnormal_chromosome_stability4.60014990
3MP0004957_abnormal_blastocyst_morpholog4.39567564
4MP0003111_abnormal_nucleus_morphology4.38453097
5MP0003077_abnormal_cell_cycle4.01175740
6MP0008058_abnormal_DNA_repair3.45398867
7MP0008007_abnormal_cellular_replicative3.24324147
8MP0008057_abnormal_DNA_replication3.21059102
9MP0003123_paternal_imprinting2.74810157
10MP0002102_abnormal_ear_morphology2.61150750
11MP0000569_abnormal_digit_pigmentation2.58898903
12MP0008932_abnormal_embryonic_tissue2.56418891
13MP0003718_maternal_effect2.37624253
14MP0006072_abnormal_retinal_apoptosis2.36113539
15MP0003195_calcinosis2.27626816
16MP0003806_abnormal_nucleotide_metabolis2.21962029
17MP0000516_abnormal_urinary_system2.21486629
18MP0005367_renal/urinary_system_phenotyp2.21486629
19MP0001730_embryonic_growth_arrest2.19950626
20MP0002396_abnormal_hematopoietic_system2.19426029
21MP0000350_abnormal_cell_proliferation2.10066749
22MP0003786_premature_aging2.08142773
23MP0000427_abnormal_hair_cycle2.04549950
24MP0008877_abnormal_DNA_methylation1.95309805
25MP0005253_abnormal_eye_physiology1.88547644
26MP0010307_abnormal_tumor_latency1.86765916
27MP0010352_gastrointestinal_tract_polyps1.83029009
28MP0000490_abnormal_crypts_of1.81095538
29MP0002837_dystrophic_cardiac_calcinosis1.75598629
30MP0002009_preneoplasia1.74292867
31MP0002938_white_spotting1.68005501
32MP0001697_abnormal_embryo_size1.60094578
33MP0010234_abnormal_vibrissa_follicle1.58430235
34MP0003787_abnormal_imprinting1.56058326
35MP0003186_abnormal_redox_activity1.55106601
36MP0008875_abnormal_xenobiotic_pharmacok1.53955855
37MP0005380_embryogenesis_phenotype1.52459515
38MP0001672_abnormal_embryogenesis/_devel1.52459515
39MP0009333_abnormal_splenocyte_physiolog1.51499449
40MP0004808_abnormal_hematopoietic_stem1.50702010
41MP0001661_extended_life_span1.50361717
42MP0000372_irregular_coat_pigmentation1.48810665
43MP0003880_abnormal_central_pattern1.46684391
44MP0003763_abnormal_thymus_physiology1.46073778
45MP0002019_abnormal_tumor_incidence1.45906387
46MP0002080_prenatal_lethality1.45492964
47MP0000313_abnormal_cell_death1.45485234
48MP0002638_abnormal_pupillary_reflex1.42458231
49MP0000647_abnormal_sebaceous_gland1.39182413
50MP0003984_embryonic_growth_retardation1.36554181
51MP0001545_abnormal_hematopoietic_system1.33910848
52MP0005397_hematopoietic_system_phenotyp1.33910848
53MP0002090_abnormal_vision1.33572701
54MP0002088_abnormal_embryonic_growth/wei1.33363651
55MP0003937_abnormal_limbs/digits/tail_de1.30860506
56MP0005084_abnormal_gallbladder_morpholo1.29446859
57MP0010678_abnormal_skin_adnexa1.29181231
58MP0002254_reproductive_system_inflammat1.28825534
59MP0003315_abnormal_perineum_morphology1.27786872
60MP0003567_abnormal_fetal_cardiomyocyte1.26846582
61MP0005551_abnormal_eye_electrophysiolog1.26561051
62MP0001529_abnormal_vocalization1.25450235
63MP0002006_tumorigenesis1.24798438
64MP0008872_abnormal_physiological_respon1.24339500
65MP0003121_genomic_imprinting1.22465859
66MP0002085_abnormal_embryonic_tissue1.22124051
67MP0002086_abnormal_extraembryonic_tissu1.20781200
68MP0004215_abnormal_myocardial_fiber1.20329680
69MP0002210_abnormal_sex_determination1.20306771
70MP0001119_abnormal_female_reproductive1.19347170
71MP0002132_abnormal_respiratory_system1.18641430
72MP0005174_abnormal_tail_pigmentation1.18440764
73MP0001835_abnormal_antigen_presentation1.17387486
74MP0002398_abnormal_bone_marrow1.16698524
75MP0009697_abnormal_copulation1.15293754
76MP0002166_altered_tumor_susceptibility1.10988390
77MP0000015_abnormal_ear_pigmentation1.09515959
78MP0003011_delayed_dark_adaptation1.09372370
79MP0000689_abnormal_spleen_morphology1.08200818
80MP0002722_abnormal_immune_system1.08063210
81MP0000383_abnormal_hair_follicle1.07869364
82MP0002084_abnormal_developmental_patter1.06194846
83MP0001145_abnormal_male_reproductive1.01187809
84MP0004197_abnormal_fetal_growth/weight/1.01118912
85MP0002736_abnormal_nociception_after1.00528589
86MP0000703_abnormal_thymus_morphology1.00338159
87MP0002751_abnormal_autonomic_nervous1.00095548
88MP0002160_abnormal_reproductive_system0.99938097
89MP0005171_absent_coat_pigmentation0.99017604
90MP0005671_abnormal_response_to0.98190175
91MP0000653_abnormal_sex_gland0.96910418
92MP0006054_spinal_hemorrhage0.95331198
93MP0002429_abnormal_blood_cell0.94937552
94MP0005389_reproductive_system_phenotype0.94710194
95MP0000358_abnormal_cell_content/0.93811805
96MP0001929_abnormal_gametogenesis0.93355704
97MP0005248_abnormal_Harderian_gland0.93119046
98MP0001984_abnormal_olfaction0.88791751
99MP0001986_abnormal_taste_sensitivity0.88320193
100MP0005187_abnormal_penis_morphology0.88196089
101MP0004133_heterotaxia0.87426132
102MP0005391_vision/eye_phenotype0.87420886
103MP0002095_abnormal_skin_pigmentation0.87012570
104MP0001853_heart_inflammation0.86350344
105MP0008260_abnormal_autophagy0.86278084
106MP0001919_abnormal_reproductive_system0.85066850
107MP0009785_altered_susceptibility_to0.84908506
108MP0004264_abnormal_extraembryonic_tissu0.84806716
109MP0005384_cellular_phenotype0.84056564
110MP0000858_altered_metastatic_potential0.83973678
111MP0001293_anophthalmia0.83306855
112MP0000716_abnormal_immune_system0.83104831
113MP0005023_abnormal_wound_healing0.82456047
114MP0006292_abnormal_olfactory_placode0.82025971
115MP0010030_abnormal_orbit_morphology0.80163613
116MP0005075_abnormal_melanosome_morpholog0.79495265
117MP0009046_muscle_twitch0.78640979
118MP0002876_abnormal_thyroid_physiology0.78355482
119MP0005645_abnormal_hypothalamus_physiol0.77934142
120MP0003941_abnormal_skin_development0.77344576
121MP0005621_abnormal_cell_physiology0.77061246
122MP0005646_abnormal_pituitary_gland0.76839893
123MP0002234_abnormal_pharynx_morphology0.76549614
124MP0001915_intracranial_hemorrhage0.75810667
125MP0000613_abnormal_salivary_gland0.75765321
126MP0004147_increased_porphyrin_level0.75570868
127MP0002653_abnormal_ependyma_morphology0.74869498
128MP0002452_abnormal_antigen_presenting0.73512879
129MP0000631_abnormal_neuroendocrine_gland0.72937291
130MP0001800_abnormal_humoral_immune0.72663221
131MP0003221_abnormal_cardiomyocyte_apopto0.72060744
132MP0002420_abnormal_adaptive_immunity0.71748585
133MP0003890_abnormal_embryonic-extraembry0.71662047
134MP0001819_abnormal_immune_cell0.71386874
135MP0001324_abnormal_eye_pigmentation0.70682958
136MP0000685_abnormal_immune_system0.69979482
137MP0001968_abnormal_touch/_nociception0.69975238
138MP0003943_abnormal_hepatobiliary_system0.69493527
139MP0009780_abnormal_chondrocyte_physiolo0.68454212
140MP0006036_abnormal_mitochondrial_physio0.68000699
141MP0005395_other_phenotype0.67435404
142MP0005167_abnormal_blood-brain_barrier0.67420375
143MP0003699_abnormal_female_reproductive0.65561919
144MP0002282_abnormal_trachea_morphology0.64982085
145MP0000477_abnormal_intestine_morphology0.64676067
146MP0008775_abnormal_heart_ventricle0.64422679
147MP0005332_abnormal_amino_acid0.63972081
148MP0001873_stomach_inflammation0.62268143
149MP0003566_abnormal_cell_adhesion0.62167906
150MP0005076_abnormal_cell_differentiation0.61665247
151MP0010155_abnormal_intestine_physiology0.61192542
152MP0003436_decreased_susceptibility_to0.60387834
153MP0002405_respiratory_system_inflammati0.60217016
154MP0002723_abnormal_immune_serum0.59888697
155MP0000465_gastrointestinal_hemorrhage0.59165748
156MP0001764_abnormal_homeostasis0.58489759
157MP0006035_abnormal_mitochondrial_morpho0.57776722
158MP0005266_abnormal_metabolism0.57440878
159MP0009053_abnormal_anal_canal0.57249502

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.89635468
2Breast hypoplasia (HP:0003187)4.57251074
3Thyroiditis (HP:0100646)4.02156075
4Abnormality of the anterior horn cell (HP:0006802)3.72298860
5Degeneration of anterior horn cells (HP:0002398)3.72298860
6Carpal bone hypoplasia (HP:0001498)3.68443188
7B lymphocytopenia (HP:0010976)3.64230272
8Oral leukoplakia (HP:0002745)3.46760931
9Chromsome breakage (HP:0040012)3.41889775
10Patellar aplasia (HP:0006443)3.34759873
11Abnormality of B cell number (HP:0010975)3.29783415
12Pancreatic cysts (HP:0001737)3.29657028
13Reticulocytopenia (HP:0001896)3.27952690
14Aplastic anemia (HP:0001915)3.24491234
15Colon cancer (HP:0003003)3.19707373
16Abnormality of cells of the erythroid lineage (HP:0012130)3.16524447
17Abnormal number of erythroid precursors (HP:0012131)3.14427198
18Aplasia/Hypoplasia of the patella (HP:0006498)3.14236442
19Chromosomal breakage induced by crosslinking agents (HP:0003221)3.12977538
20Severe combined immunodeficiency (HP:0004430)3.00709033
21Rough bone trabeculation (HP:0100670)2.96766599
22Cerebral hypomyelination (HP:0006808)2.90139012
23Agnosia (HP:0010524)2.89768343
24Neoplasm of the adrenal cortex (HP:0100641)2.87994071
25Meckel diverticulum (HP:0002245)2.87721736
26Abnormality of chromosome stability (HP:0003220)2.83024993
27Abnormality of the preputium (HP:0100587)2.79125022
28Pancreatic fibrosis (HP:0100732)2.76436546
29Hypoproteinemia (HP:0003075)2.74891953
30Myelodysplasia (HP:0002863)2.74257899
31Medulloblastoma (HP:0002885)2.71788030
32Abnormality of the ileum (HP:0001549)2.71220702
33Selective tooth agenesis (HP:0001592)2.69999931
34Intestinal atresia (HP:0011100)2.66137940
3511 pairs of ribs (HP:0000878)2.61320271
36Absent thumb (HP:0009777)2.59156024
37Combined immunodeficiency (HP:0005387)2.58666889
38Hypothermia (HP:0002045)2.57273250
39Volvulus (HP:0002580)2.54399060
40Microretrognathia (HP:0000308)2.52897357
41Small intestinal stenosis (HP:0012848)2.50296355
42Duodenal stenosis (HP:0100867)2.50296355
43Pancreatic islet-cell hyperplasia (HP:0004510)2.49896080
44Secondary amenorrhea (HP:0000869)2.48945484
45Thrombocytosis (HP:0001894)2.48541992
46Abnormal lung lobation (HP:0002101)2.48119789
47Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.47064021
48True hermaphroditism (HP:0010459)2.46723288
49Bone marrow hypocellularity (HP:0005528)2.39218217
50Aplasia/Hypoplasia of the uvula (HP:0010293)2.38485803
51Absent radius (HP:0003974)2.38419002
52Rhabdomyosarcoma (HP:0002859)2.38052337
53Medial flaring of the eyebrow (HP:0010747)2.37794779
54Neoplasm of the adrenal gland (HP:0100631)2.37082206
55Premature ovarian failure (HP:0008209)2.36900499
56Methylmalonic acidemia (HP:0002912)2.36674495
57Abnormality of the labia minora (HP:0012880)2.34972958
58Clubbing of toes (HP:0100760)2.31637883
59Sloping forehead (HP:0000340)2.30460187
60Type I transferrin isoform profile (HP:0003642)2.30235496
61Cutaneous melanoma (HP:0012056)2.28263904
62Neoplasm of the pancreas (HP:0002894)2.26345583
63Hypoplasia of the capital femoral epiphysis (HP:0003090)2.25490381
64Abnormality of midbrain morphology (HP:0002418)2.25016272
65Molar tooth sign on MRI (HP:0002419)2.25016272
66Irregular epiphyses (HP:0010582)2.24494716
67Abnormality of glycolysis (HP:0004366)2.22898115
68Increased serum pyruvate (HP:0003542)2.22898115
69Horseshoe kidney (HP:0000085)2.21935029
70Absent forearm bone (HP:0003953)2.19027420
71Aplasia involving forearm bones (HP:0009822)2.19027420
72Abnormal trabecular bone morphology (HP:0100671)2.16612613
73Premature graying of hair (HP:0002216)2.14533986
74Abnormality of aspartate family amino acid metabolism (HP:0010899)2.14254626
75Multiple enchondromatosis (HP:0005701)2.12949936
76Abnormality of methionine metabolism (HP:0010901)2.12752338
77Cellular immunodeficiency (HP:0005374)2.12235057
78Macrocytic anemia (HP:0001972)2.11196714
79Aplasia/Hypoplasia of the sacrum (HP:0008517)2.11072244
80Supernumerary spleens (HP:0009799)2.10737001
81Hyperinsulinemic hypoglycemia (HP:0000825)2.10708206
82Hypoplasia of the thymus (HP:0000778)2.09905010
83Impulsivity (HP:0100710)2.09901142
84Cleft eyelid (HP:0000625)2.09113814
85Amaurosis fugax (HP:0100576)2.07855802
86Neoplasm of the colon (HP:0100273)2.07374535
87Congenital stationary night blindness (HP:0007642)2.06880253
88Abnormality of the duodenum (HP:0002246)2.05507419
89Poor head control (HP:0002421)2.04349915
90Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.04211273
91Abnormality of alanine metabolism (HP:0010916)2.04211273
92Hyperalaninemia (HP:0003348)2.04211273
93Optic nerve coloboma (HP:0000588)2.03242695
94Glioma (HP:0009733)2.02686595
95Ependymoma (HP:0002888)2.02684939
96Stenosis of the external auditory canal (HP:0000402)2.01475738
97Trismus (HP:0000211)2.01467297
98Progressive inability to walk (HP:0002505)2.00949366
99Abnormality of the renal cortex (HP:0011035)2.00913966
100Aplasia/Hypoplasia of the sternum (HP:0006714)2.00017514
101Slender long bone (HP:0003100)1.99124352
102Entropion (HP:0000621)1.97873660
103Breast carcinoma (HP:0003002)1.94560364
104Atrophy/Degeneration involving motor neurons (HP:0007373)1.94471085
105Pallor (HP:0000980)1.93600306
106Muscle fiber atrophy (HP:0100295)1.93574576
107Type 2 muscle fiber atrophy (HP:0003554)1.93507347
108Lymphoma (HP:0002665)1.93381885
109Aplasia/Hypoplasia of the tongue (HP:0010295)1.92290603
110Prostate neoplasm (HP:0100787)1.92011570
111Nephronophthisis (HP:0000090)1.89982290
112Glossoptosis (HP:0000162)1.89461945
113Abnormal spermatogenesis (HP:0008669)1.88895167
114Pulmonary fibrosis (HP:0002206)1.88646358
115Increased serum lactate (HP:0002151)1.88499989
116Ketoacidosis (HP:0001993)1.88325194
117Erythroderma (HP:0001019)1.87867834
118Oligodactyly (hands) (HP:0001180)1.87612742
119Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.87230830
120Decreased activity of mitochondrial respiratory chain (HP:0008972)1.87230830
121Hypoglycemic coma (HP:0001325)1.87092032
122Fair hair (HP:0002286)1.86853944
123Abnormality of the astrocytes (HP:0100707)1.86836004
124Astrocytoma (HP:0009592)1.86836004
125Attenuation of retinal blood vessels (HP:0007843)1.85864323
126Hypoglycemic seizures (HP:0002173)1.85576668
127Preaxial hand polydactyly (HP:0001177)1.85440315
128Atresia of the external auditory canal (HP:0000413)1.84609980
129Triphalangeal thumb (HP:0001199)1.82751079
130Ectopic kidney (HP:0000086)1.82591851
131CNS hypomyelination (HP:0003429)1.82322146
132Absent epiphyses (HP:0010577)1.81647951
133Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.81647951
134Tongue fasciculations (HP:0001308)1.81197756
135Abnormality of the carotid arteries (HP:0005344)1.80981964
136Methylmalonic aciduria (HP:0012120)1.79562635
137Pendular nystagmus (HP:0012043)1.79194095
138Basal cell carcinoma (HP:0002671)1.79005024
139Squamous cell carcinoma (HP:0002860)1.78815749
140Nephroblastoma (Wilms tumor) (HP:0002667)1.78671330
141Increased CSF lactate (HP:0002490)1.78624013
142Abnormality of the pancreatic islet cells (HP:0006476)1.77893153
143Abnormality of endocrine pancreas physiology (HP:0012093)1.77893153
144Aqueductal stenosis (HP:0002410)1.77280847
145Sparse eyelashes (HP:0000653)1.76912834
146Pancytopenia (HP:0001876)1.76643008
147Disproportionate short-trunk short stature (HP:0003521)1.76592326
148Ovarian neoplasm (HP:0100615)1.75682392
149Bile duct proliferation (HP:0001408)1.75607731
150Abnormal biliary tract physiology (HP:0012439)1.75607731
151Tracheoesophageal fistula (HP:0002575)1.75331039
152Spinal muscular atrophy (HP:0007269)1.74936411
153Abnormality of cochlea (HP:0000375)1.74325089
154Congenital primary aphakia (HP:0007707)1.74243427
155Renal cortical cysts (HP:0000803)1.73827735
156Facial cleft (HP:0002006)1.73751617
157Abnormal umbilical cord blood vessels (HP:0011403)1.72896730
158Single umbilical artery (HP:0001195)1.72896730
159Abnormality of the fetal cardiovascular system (HP:0010948)1.72896730
160Anencephaly (HP:0002323)1.71678597
161Congenital, generalized hypertrichosis (HP:0004540)1.70885027
162Abnormality of serum amino acid levels (HP:0003112)1.70756604
163Lissencephaly (HP:0001339)1.69974904
164Embryonal renal neoplasm (HP:0011794)1.68696871
165Lipid accumulation in hepatocytes (HP:0006561)1.68679090
166Dandy-Walker malformation (HP:0001305)1.66375419
167Abnormality of the renal medulla (HP:0100957)1.65058559
168Small hand (HP:0200055)1.64446627
169Delayed gross motor development (HP:0002194)1.64395510
170Bifid tongue (HP:0010297)1.62739383
171Aplasia/hypoplasia of the uterus (HP:0008684)1.62235626
172Gaze-evoked nystagmus (HP:0000640)1.62183348
173Thin upper lip vermilion (HP:0000219)1.61982185
174Increased hepatocellular lipid droplets (HP:0006565)1.61151939
175Gait imbalance (HP:0002141)1.60725638
176Sclerocornea (HP:0000647)1.60536735

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.05241207
2FRK4.04651040
3EIF2AK13.99045812
4WEE13.89305856
5CDC73.34518199
6TRIM283.18319657
7SRPK12.87838527
8PLK42.86494526
9TSSK62.79687873
10ACVR1B2.48676701
11EIF2AK32.30597334
12NEK12.28073399
13TTK2.26916657
14NEK22.26876501
15STK162.21030466
16BRSK22.14859269
17WNK32.04539619
18NME21.97417087
19PLK11.95204517
20MAP4K21.90866261
21PLK31.78680272
22TNIK1.76665981
23VRK11.69282488
24MKNK11.68387642
25TAF11.65478082
26CCNB11.64931030
27AURKB1.62157980
28PASK1.60007904
29TGFBR11.58692186
30TESK21.52194684
31ATR1.46324267
32INSRR1.46049659
33RPS6KB21.45121749
34PLK21.44424057
35ZAK1.44059022
36STK391.43644052
37PNCK1.42179678
38VRK21.41830467
39STK101.34676592
40BCR1.31429736
41CDK71.26783659
42FLT31.23845975
43MAP3K81.23572375
44TLK11.22323863
45BRSK11.21868701
46CHEK21.20055521
47BRAF1.19899164
48OXSR11.19226218
49MKNK21.19157496
50AURKA1.19081724
51RPS6KA41.18101215
52MAP3K121.16980211
53MAP3K41.15976932
54EPHA21.14839867
55CSNK1G11.11954038
56CDK81.11322178
57GRK11.11133528
58DYRK31.10198181
59PBK1.08597159
60PAK31.04802293
61AKT31.04477157
62CSNK1G30.98671446
63PIM20.96345150
64EIF2AK20.96238432
65MAPK130.96149975
66FGFR20.95950770
67PINK10.95668396
68STK40.93502016
69CAMKK20.92332154
70CDK40.91100014
71CSNK1A1L0.91071138
72SCYL20.90278396
73CHEK10.88755971
74KDR0.86542635
75PIM10.86492080
76PAK40.85272620
77STK38L0.84168655
78CASK0.82617619
79CSNK1G20.82274000
80ADRBK20.81568271
81TESK10.79427292
82NEK90.79358325
83SIK30.72288061
84MELK0.72146314
85FER0.70019769
86ATM0.67957409
87BMPR20.66505050
88MAP4K10.65012138
89CSNK2A10.64669375
90NLK0.64289879
91EEF2K0.61237272
92ZAP700.60846389
93WNK40.59852626
94CAMK1G0.59662817
95CDK20.58721771
96TAOK20.58014950
97ERBB40.57683462
98CAMK1D0.57499256
99PAK10.56578358
100ERBB30.56239064
101CSNK2A20.55511315
102BCKDK0.54415382
103TXK0.52682943
104JAK30.52572215
105NME10.52508290
106PRKCE0.52206309
107MST40.52076979
108KIT0.51650153
109PRKCI0.48590007
110TEC0.48460481
111MAP2K30.47018210
112LRRK20.46770765
113MAPKAPK50.46184668
114MAPKAPK30.45927961
115MOS0.45862891
116STK30.45554780
117MUSK0.43184272
118CDK10.43155177
119NUAK10.41507045
120MAP2K70.40588175
121BTK0.38975943
122PDK40.38748527
123PDK30.38748527
124CLK10.37749111
125MINK10.37394483
126LATS10.36743175
127STK240.36549464
128MAP3K50.36404467
129PHKG10.35094973
130PHKG20.35094973
131CDK90.33683689
132YES10.33072024
133DYRK20.32980475
134PKN10.32213513
135BRD40.31367174
136CDK60.31193136
137MAP3K60.31186697
138RAF10.30576545
139PKN20.29743675
140IKBKB0.27158854
141MARK30.26397301
142GRK50.25532077
143BMPR1B0.25279486
144CSNK1D0.24389357
145RPS6KA50.24225149
146PDK20.23713304
147LYN0.23238229
148DAPK10.22605310
149ABL10.22080382
150CHUK0.21789940

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.63179547
2Mismatch repair_Homo sapiens_hsa034303.99683451
3Proteasome_Homo sapiens_hsa030503.94163105
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.71159759
5RNA polymerase_Homo sapiens_hsa030203.46348134
6RNA transport_Homo sapiens_hsa030133.04707965
7Spliceosome_Homo sapiens_hsa030403.04441545
8Homologous recombination_Homo sapiens_hsa034403.03456879
9Base excision repair_Homo sapiens_hsa034102.94070702
10Ribosome_Homo sapiens_hsa030102.92260033
11Nucleotide excision repair_Homo sapiens_hsa034202.86686901
12Cell cycle_Homo sapiens_hsa041102.69596781
13Pyrimidine metabolism_Homo sapiens_hsa002402.48440024
14One carbon pool by folate_Homo sapiens_hsa006702.48085455
15Propanoate metabolism_Homo sapiens_hsa006402.44588110
16Caffeine metabolism_Homo sapiens_hsa002322.40713114
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.37907513
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.23053569
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.18453353
20Basal transcription factors_Homo sapiens_hsa030222.16353075
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.15502987
22Non-homologous end-joining_Homo sapiens_hsa034502.10444979
23Fanconi anemia pathway_Homo sapiens_hsa034602.09994881
24Sulfur metabolism_Homo sapiens_hsa009202.05147339
25RNA degradation_Homo sapiens_hsa030181.89926597
26Fatty acid elongation_Homo sapiens_hsa000621.80335248
27p53 signaling pathway_Homo sapiens_hsa041151.53433548
28Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.51062208
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.46938069
30Nitrogen metabolism_Homo sapiens_hsa009101.44589745
31Purine metabolism_Homo sapiens_hsa002301.41754805
32Butanoate metabolism_Homo sapiens_hsa006501.39573564
33mRNA surveillance pathway_Homo sapiens_hsa030151.39424018
34Phototransduction_Homo sapiens_hsa047441.35936080
35Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.33880065
36Epstein-Barr virus infection_Homo sapiens_hsa051691.24036776
37Steroid biosynthesis_Homo sapiens_hsa001001.23898861
38Folate biosynthesis_Homo sapiens_hsa007901.12921593
39Fatty acid metabolism_Homo sapiens_hsa012121.10688122
40Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.09663114
41Protein export_Homo sapiens_hsa030601.09325840
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.06330067
43Vitamin B6 metabolism_Homo sapiens_hsa007501.06015673
44Maturity onset diabetes of the young_Homo sapiens_hsa049501.03285826
45Oxidative phosphorylation_Homo sapiens_hsa001901.02870622
46Ether lipid metabolism_Homo sapiens_hsa005651.02061014
47Herpes simplex infection_Homo sapiens_hsa051681.00738665
48Antigen processing and presentation_Homo sapiens_hsa046121.00114506
49Systemic lupus erythematosus_Homo sapiens_hsa053220.98727977
50Tryptophan metabolism_Homo sapiens_hsa003800.97883623
51Legionellosis_Homo sapiens_hsa051340.94935216
52Pentose phosphate pathway_Homo sapiens_hsa000300.93270635
53Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.92834329
54Peroxisome_Homo sapiens_hsa041460.91480086
55alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.90905261
56Biosynthesis of amino acids_Homo sapiens_hsa012300.90681905
57Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.90270867
58Primary bile acid biosynthesis_Homo sapiens_hsa001200.88832166
59Oocyte meiosis_Homo sapiens_hsa041140.86685526
60Drug metabolism - other enzymes_Homo sapiens_hsa009830.83765146
61Viral carcinogenesis_Homo sapiens_hsa052030.83732467
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.79245167
63Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.78629800
64Selenocompound metabolism_Homo sapiens_hsa004500.76940131
65Circadian rhythm_Homo sapiens_hsa047100.75314040
66Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.75152945
67Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.74452343
68Linoleic acid metabolism_Homo sapiens_hsa005910.74191104
69Cyanoamino acid metabolism_Homo sapiens_hsa004600.72943076
70Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.72162021
71Thyroid cancer_Homo sapiens_hsa052160.69817870
72beta-Alanine metabolism_Homo sapiens_hsa004100.67699195
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.67205724
74Collecting duct acid secretion_Homo sapiens_hsa049660.63512852
75HTLV-I infection_Homo sapiens_hsa051660.61115041
76Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.60972006
77Carbon metabolism_Homo sapiens_hsa012000.56958873
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56159739
79Sulfur relay system_Homo sapiens_hsa041220.54999235
80Glutathione metabolism_Homo sapiens_hsa004800.53713690
81Primary immunodeficiency_Homo sapiens_hsa053400.53697804
82Fructose and mannose metabolism_Homo sapiens_hsa000510.51099237
83Shigellosis_Homo sapiens_hsa051310.49459747
842-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.49080104
85Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.48800768
86Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48354042
87Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.47818943
88N-Glycan biosynthesis_Homo sapiens_hsa005100.44809212
89Measles_Homo sapiens_hsa051620.44681948
90Apoptosis_Homo sapiens_hsa042100.44170167
91NF-kappa B signaling pathway_Homo sapiens_hsa040640.42331959
92NOD-like receptor signaling pathway_Homo sapiens_hsa046210.42170558
93RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.41651767
94Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.40941156
95Huntingtons disease_Homo sapiens_hsa050160.40845149
96Fatty acid degradation_Homo sapiens_hsa000710.40524933
97Lysine degradation_Homo sapiens_hsa003100.40490681
98Regulation of autophagy_Homo sapiens_hsa041400.39497572
99Galactose metabolism_Homo sapiens_hsa000520.39496643
100Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.39087352
101Influenza A_Homo sapiens_hsa051640.39001113
102Pentose and glucuronate interconversions_Homo sapiens_hsa000400.38485868
103Intestinal immune network for IgA production_Homo sapiens_hsa046720.37818994
104Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.37799669
105Retinol metabolism_Homo sapiens_hsa008300.37523730
106Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37082664
107Small cell lung cancer_Homo sapiens_hsa052220.34599160
108Allograft rejection_Homo sapiens_hsa053300.34431089
109Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.34106427
110Transcriptional misregulation in cancer_Homo sapiens_hsa052020.32635855
111TGF-beta signaling pathway_Homo sapiens_hsa043500.32505065
112Steroid hormone biosynthesis_Homo sapiens_hsa001400.32440988
113Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.30460131
114Hematopoietic cell lineage_Homo sapiens_hsa046400.29877270
115Chemical carcinogenesis_Homo sapiens_hsa052040.29518175
116Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.29473165
117Metabolic pathways_Homo sapiens_hsa011000.28213161
118Hepatitis B_Homo sapiens_hsa051610.27676843
119MicroRNAs in cancer_Homo sapiens_hsa052060.27567180
120Hedgehog signaling pathway_Homo sapiens_hsa043400.24489826
121Alzheimers disease_Homo sapiens_hsa050100.23444391
122SNARE interactions in vesicular transport_Homo sapiens_hsa041300.21768421
123Alcoholism_Homo sapiens_hsa050340.20957298
124Parkinsons disease_Homo sapiens_hsa050120.20875056
125Graft-versus-host disease_Homo sapiens_hsa053320.20476437
126Olfactory transduction_Homo sapiens_hsa047400.19598617
127Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.19386508
128Other glycan degradation_Homo sapiens_hsa005110.18448393
129Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.17459835
130Colorectal cancer_Homo sapiens_hsa052100.17204835
131Type I diabetes mellitus_Homo sapiens_hsa049400.17110134
132Renin-angiotensin system_Homo sapiens_hsa046140.17054520
133Asthma_Homo sapiens_hsa053100.16578554
134HIF-1 signaling pathway_Homo sapiens_hsa040660.15725398
135Arachidonic acid metabolism_Homo sapiens_hsa005900.13798766
136Leishmaniasis_Homo sapiens_hsa051400.12969570
137Pyruvate metabolism_Homo sapiens_hsa006200.11668699
138Hippo signaling pathway_Homo sapiens_hsa043900.10886887
139Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.10769027
140Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.10515805
141Autoimmune thyroid disease_Homo sapiens_hsa053200.09526754
142Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.08654337

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