SMURF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a ubiquitin ligase that is specific for receptor-regulated SMAD proteins in the bone morphogenetic protein (BMP) pathway. This protein plays a key roll in the regulation of cell motility, cell signalling, and cell polarity. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)4.00075460
2protein localization to endosome (GO:0036010)3.85618878
3plasma membrane repair (GO:0001778)3.81594337
4cell adhesion mediated by integrin (GO:0033627)3.69144841
5cytoskeletal anchoring at plasma membrane (GO:0007016)3.61444689
6hypotonic response (GO:0006971)3.36142314
7stress fiber assembly (GO:0043149)3.28509700
8semaphorin-plexin signaling pathway (GO:0071526)3.28112787
9protein heterotrimerization (GO:0070208)3.25819262
10embryonic process involved in female pregnancy (GO:0060136)3.20900928
11regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.19300811
12cortical actin cytoskeleton organization (GO:0030866)3.07099057
13regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.01054001
14skin morphogenesis (GO:0043589)2.99865260
15apoptotic cell clearance (GO:0043277)2.96772469
16low-density lipoprotein particle clearance (GO:0034383)2.95801104
17hippo signaling (GO:0035329)2.93941428
18adherens junction assembly (GO:0034333)2.93092744
19surfactant homeostasis (GO:0043129)2.92275224
20histone H3-K36 demethylation (GO:0070544)2.91505710
21regulation of transforming growth factor beta2 production (GO:0032909)2.88400936
22mannose metabolic process (GO:0006013)2.88243710
23endodermal cell differentiation (GO:0035987)2.87264020
24growth hormone receptor signaling pathway (GO:0060396)2.86296469
25regulation of NFAT protein import into nucleus (GO:0051532)2.86246069
26cell-substrate junction assembly (GO:0007044)2.84758577
27hemidesmosome assembly (GO:0031581)2.84301258
28activation of Rac GTPase activity (GO:0032863)2.81791903
29COPI coating of Golgi vesicle (GO:0048205)2.81547375
30Golgi transport vesicle coating (GO:0048200)2.81547375
31negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.80696276
32barbed-end actin filament capping (GO:0051016)2.80243127
33positive regulation of blood vessel endothelial cell migration (GO:0043536)2.79813396
34basement membrane organization (GO:0071711)2.79013335
35regulation of hippo signaling (GO:0035330)2.76681247
36regulation of water loss via skin (GO:0033561)2.69571079
37negative regulation of fatty acid transport (GO:2000192)2.69015794
38positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.68610698
39peripheral nervous system axon ensheathment (GO:0032292)2.67220026
40myelination in peripheral nervous system (GO:0022011)2.67220026
41retina vasculature morphogenesis in camera-type eye (GO:0061299)2.64255314
42epithelial cell-cell adhesion (GO:0090136)2.62637866
43endocardial cushion development (GO:0003197)2.61326374
44negative regulation of catenin import into nucleus (GO:0035414)2.60142764
45nuclear pore complex assembly (GO:0051292)2.60059919
46cortical cytoskeleton organization (GO:0030865)2.59811487
47positive regulation of Cdc42 GTPase activity (GO:0043089)2.54975620
48regulation of p38MAPK cascade (GO:1900744)2.54021272
49layer formation in cerebral cortex (GO:0021819)2.53325147
50endocytic recycling (GO:0032456)2.52624300
51regulation of ARF GTPase activity (GO:0032312)2.52412550
52regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.51626207
53planar cell polarity pathway involved in neural tube closure (GO:0090179)2.50417707
54negative regulation of anoikis (GO:2000811)2.50277602
55adhesion of symbiont to host cell (GO:0044650)2.50257353
56virion attachment to host cell (GO:0019062)2.50257353
57cytoplasmic mRNA processing body assembly (GO:0033962)2.49860386
58membrane raft organization (GO:0031579)2.47029619
59chemical homeostasis within a tissue (GO:0048875)2.44703704
60polarized epithelial cell differentiation (GO:0030859)2.44311281
61focal adhesion assembly (GO:0048041)2.42962879
62cell-substrate adherens junction assembly (GO:0007045)2.42962879
63vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.42700828
64histone lysine demethylation (GO:0070076)2.41730808
65cellular response to growth hormone stimulus (GO:0071378)2.41399902
66collagen fibril organization (GO:0030199)2.41019545
67regulation of glucose import in response to insulin stimulus (GO:2001273)2.40551304
68negative regulation of potassium ion transmembrane transport (GO:1901380)2.39421787
69positive regulation of extracellular matrix organization (GO:1903055)2.38524993
70ruffle organization (GO:0031529)2.38304207
71cardiac myofibril assembly (GO:0055003)2.37601120
72regulation of early endosome to late endosome transport (GO:2000641)2.37571352
73regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.37476161
74negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.36967520
75histone demethylation (GO:0016577)2.36368487
76regulation of tight junction assembly (GO:2000810)2.36340487
77protein targeting to plasma membrane (GO:0072661)2.36251195
78camera-type eye morphogenesis (GO:0048593)2.36191132
79regulation of nucleobase-containing compound transport (GO:0032239)2.34901310
80bundle of His cell to Purkinje myocyte communication (GO:0086069)2.34395504
81renal filtration (GO:0097205)2.32965189
82membrane protein ectodomain proteolysis (GO:0006509)2.32497115
83insulin-like growth factor receptor signaling pathway (GO:0048009)2.32348858
84positive regulation of glycogen biosynthetic process (GO:0045725)2.31894022
85keratinocyte proliferation (GO:0043616)2.31825736
86endothelial cell chemotaxis (GO:0035767)2.31347073
87epithelial cell differentiation involved in prostate gland development (GO:0060742)2.30798153
88cell migration involved in sprouting angiogenesis (GO:0002042)2.30627887
89platelet-derived growth factor receptor signaling pathway (GO:0048008)2.29945485
90response to nerve growth factor (GO:1990089)2.29610151
91cellular response to nerve growth factor stimulus (GO:1990090)2.29610151
92actin filament bundle organization (GO:0061572)2.29537900
93actin filament bundle assembly (GO:0051017)2.29537900
94regulation of cardioblast differentiation (GO:0051890)2.29448636
95atrioventricular valve morphogenesis (GO:0003181)2.29427519
96positive regulation of receptor recycling (GO:0001921)2.28735843
97negative regulation of smooth muscle cell migration (GO:0014912)2.28719396
98substrate adhesion-dependent cell spreading (GO:0034446)2.28695471
99establishment of skin barrier (GO:0061436)2.28340691
100establishment of nucleus localization (GO:0040023)2.28244543
101response to laminar fluid shear stress (GO:0034616)2.28070174
102positive regulation of p38MAPK cascade (GO:1900745)2.27360291
103response to muramyl dipeptide (GO:0032495)2.27066071
104wound healing, spreading of epidermal cells (GO:0035313)2.26199680
105adherens junction organization (GO:0034332)2.24628815
106mesodermal cell differentiation (GO:0048333)2.24606282
107sarcomere organization (GO:0045214)2.24158474
108regulation of anoikis (GO:2000209)2.23443226
109apoptotic process involved in morphogenesis (GO:0060561)2.23161083
110mammary gland epithelial cell proliferation (GO:0033598)2.22861409
111chondrocyte proliferation (GO:0035988)2.21556271
112negative regulation of cell size (GO:0045792)2.21307140
113branching involved in mammary gland duct morphogenesis (GO:0060444)2.20673899
114regulation of cholesterol homeostasis (GO:2000188)2.20245874
115adhesion of symbiont to host (GO:0044406)2.19767811
116neuron projection extension involved in neuron projection guidance (GO:1902284)2.19385480
117axon extension involved in axon guidance (GO:0048846)2.19385480
118embryonic viscerocranium morphogenesis (GO:0048703)2.19330590
119branching involved in salivary gland morphogenesis (GO:0060445)2.18972779
120regulation of transforming growth factor beta1 production (GO:0032908)2.18493937
121regulation of membrane protein ectodomain proteolysis (GO:0051043)2.18438306
122positive regulation of keratinocyte differentiation (GO:0045618)2.17823020
123negative regulation of erythrocyte differentiation (GO:0045647)2.17766434
124establishment of endothelial barrier (GO:0061028)2.17571150
125regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.17558696
126maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.17240030
127dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.16954924
128positive regulation of Rho protein signal transduction (GO:0035025)2.16774493
129embryonic eye morphogenesis (GO:0048048)2.16424289
130regulation of RNA export from nucleus (GO:0046831)2.16204152
131actin cytoskeleton reorganization (GO:0031532)2.15786108
132histone H3-K9 demethylation (GO:0033169)2.15734478
133positive regulation of myotube differentiation (GO:0010831)2.14716391
134regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.14257522
135positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.13693315
136cell volume homeostasis (GO:0006884)2.13628599
137paraxial mesoderm development (GO:0048339)2.12267696
138negative regulation of chondrocyte differentiation (GO:0032331)2.11648019
139regulation of integrin activation (GO:0033623)2.11605646
140peptidyl-lysine dimethylation (GO:0018027)2.11338557
141positive regulation of endothelial cell apoptotic process (GO:2000353)2.10025388
142substrate-dependent cell migration (GO:0006929)2.09528681
143regulation of endothelial cell chemotaxis (GO:2001026)2.09253837
144positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.08687830
145response to fluid shear stress (GO:0034405)2.08448770
146positive regulation of axon extension (GO:0045773)2.08278543
147dendrite morphogenesis (GO:0048813)2.08134123
148membrane tubulation (GO:0097320)2.07132487
149axon extension (GO:0048675)2.06574183
150negative regulation of focal adhesion assembly (GO:0051895)2.06462548
151negative regulation of cell junction assembly (GO:1901889)2.06462548
152negative regulation of adherens junction organization (GO:1903392)2.06462548
153bone trabecula formation (GO:0060346)2.06177412
154negative regulation of cardiac muscle tissue growth (GO:0055022)2.05740226
155negative regulation of heart growth (GO:0061117)2.05740226
156cell junction assembly (GO:0034329)2.05451245
157extracellular matrix disassembly (GO:0022617)2.05345920
158vascular endothelial growth factor signaling pathway (GO:0038084)2.05197802
159cell-cell junction maintenance (GO:0045217)2.04380910
160peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.02677615
161endothelial cell morphogenesis (GO:0001886)2.02501722
162cell migration in hindbrain (GO:0021535)2.00991619

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human3.21957920
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.94062491
3TRIM28_21343339_ChIP-Seq_HEK293_Human2.74564534
4RARG_19884340_ChIP-ChIP_MEFs_Mouse2.54900584
5CLOCK_20551151_ChIP-Seq_293T_Human1.97548669
6KDM2B_26808549_Chip-Seq_SUP-B15_Human1.97466207
7EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.96013153
8WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.89732017
9STAT6_21828071_ChIP-Seq_BEAS2B_Human1.83599692
10ESR2_21235772_ChIP-Seq_MCF-7_Human1.80381741
11EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.78180176
12STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.77480337
13ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.76803095
14* EP300_21415370_ChIP-Seq_HL-1_Mouse1.76562648
15KDM2B_26808549_Chip-Seq_K562_Human1.76059192
16KDM2B_26808549_Chip-Seq_DND41_Human1.75539816
17* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.74478312
18RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.73221302
19* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.72349032
20DROSHA_22980978_ChIP-Seq_HELA_Human1.67625591
21FOXO3_23340844_ChIP-Seq_DLD1_Human1.65245080
22SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.60721617
23VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.59477126
24* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.57890738
25ELK3_25401928_ChIP-Seq_HUVEC_Human1.57179916
26P300_27058665_Chip-Seq_ZR-75-30cells_Human1.56799372
27PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.56378541
28CDX2_19796622_ChIP-Seq_MESCs_Mouse1.56013441
29MYC_22102868_ChIP-Seq_BL_Human1.50998610
30NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.50498806
31EGR1_19374776_ChIP-ChIP_THP-1_Human1.49935641
32ZNF263_19887448_ChIP-Seq_K562_Human1.49218897
33TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.48062401
34* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.48019793
35VDR_21846776_ChIP-Seq_THP-1_Human1.47767931
36ZNF217_24962896_ChIP-Seq_MCF-7_Human1.43902130
37KDM2B_26808549_Chip-Seq_JURKAT_Human1.38506729
38KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.37623455
39* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.36587077
40ZFP281_27345836_Chip-Seq_ESCs_Mouse1.36585386
41KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.34693896
42TBX20_22080862_ChIP-Seq_HEART_Mouse1.32676461
43TBX20_22328084_ChIP-Seq_HEART_Mouse1.32676461
44CJUN_26792858_Chip-Seq_BT549_Human1.31244527
45* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.30404560
46RACK7_27058665_Chip-Seq_MCF-7_Human1.28852419
47* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.28273342
48AHR_22903824_ChIP-Seq_MCF-7_Human1.27949402
49Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.25656193
50* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.25354003
51ESR1_20079471_ChIP-ChIP_T-47D_Human1.25135309
52KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.24414349
53NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.23633137
54HIF1A_21447827_ChIP-Seq_MCF-7_Human1.23416912
55ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.23087839
56* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.22874075
57CTNNB1_20460455_ChIP-Seq_HCT116_Human1.22827698
58TP53_16413492_ChIP-PET_HCT116_Human1.22293156
59WT1_25993318_ChIP-Seq_PODOCYTE_Human1.21681828
60TCF7_22412390_ChIP-Seq_EML_Mouse1.21167838
61ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.19984848
62GATA2_21666600_ChIP-Seq_HMVEC_Human1.19045444
63FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.18874174
64NFIB_24661679_ChIP-Seq_LUNG_Mouse1.17846612
65P63_26484246_Chip-Seq_KERATINOCYTES_Human1.17397505
66SMAD_19615063_ChIP-ChIP_OVARY_Human1.17299586
67TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17116886
68VDR_24763502_ChIP-Seq_THP-1_Human1.16933538
69LXR_22292898_ChIP-Seq_THP-1_Human1.16828377
70* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.16409180
71RUNX1_27514584_Chip-Seq_MCF-7_Human1.16112258
72SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.14311002
73MTF2_20144788_ChIP-Seq_MESCs_Mouse1.13679794
74SOX9_24532713_ChIP-Seq_HFSC_Mouse1.13388135
75NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.13355916
76CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.12865906
77TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11209030
78BRD4_27068464_Chip-Seq_AML-cells_Mouse1.09874588
79RNF2_18974828_ChIP-Seq_MESCs_Mouse1.09556055
80EZH2_18974828_ChIP-Seq_MESCs_Mouse1.09556055
81* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.09130166
82TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08641624
83* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.07335971
84* ISL1_27105846_Chip-Seq_CPCs_Mouse1.06774976
85SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05588157
86FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.05446504
87TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.04629546
88SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.03362961
89KLF5_25053715_ChIP-Seq_YYC3_Human1.03059764
90JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02057124
91SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.01950293
92JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00761165
93FOXA2_19822575_ChIP-Seq_HepG2_Human1.00489805
94* BRD4_25478319_ChIP-Seq_HGPS_Human1.00383311
95FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.99687997
96WT1_19549856_ChIP-ChIP_CCG9911_Human0.99445379
97GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99444515
98VDR_24787735_ChIP-Seq_THP-1_Human0.98734637
99SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.98695360
100CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.98579821
101ATF3_27146783_Chip-Seq_COLON_Human0.98577783
102ARNT_22903824_ChIP-Seq_MCF-7_Human0.98335867
103* UBF1/2_26484160_Chip-Seq_HMECs_Human0.98187824
104BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.97810212
105ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97366601
106RNF2_27304074_Chip-Seq_ESCs_Mouse0.97281617
107CREB1_26743006_Chip-Seq_LNCaP_Human0.97050177
108SMC1_22415368_ChIP-Seq_MEFs_Mouse0.97011703
109* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.96650448
110THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.96468785
111TP53_22127205_ChIP-Seq_IMR90_Human0.96462294
112* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.95891859
113* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.95891859
114ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.95542569
115GATA6_25053715_ChIP-Seq_YYC3_Human0.95274212
116ESR1_21235772_ChIP-Seq_MCF-7_Human0.94334423
117ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.94264517
118DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.93708803
119* RARB_27405468_Chip-Seq_BRAIN_Mouse0.93638713
120NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.93551325
121NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.93379316
122* TP53_23651856_ChIP-Seq_MEFs_Mouse0.92831739
123KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.92652686
124* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.92237822
125TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.90987220
126NRF2_20460467_ChIP-Seq_MEFs_Mouse0.89406015

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.94904066
2MP0003705_abnormal_hypodermis_morpholog4.31627376
3MP0005623_abnormal_meninges_morphology3.86755131
4MP0005275_abnormal_skin_tensile3.24454348
5MP0004272_abnormal_basement_membrane2.83215958
6MP0005409_darkened_coat_color2.75233848
7MP0003566_abnormal_cell_adhesion2.41911273
8MP0003091_abnormal_cell_migration2.32182280
9MP0004185_abnormal_adipocyte_glucose2.21083182
10MP0001958_emphysema2.08020733
11MP0000733_abnormal_muscle_development2.06275033
12MP0005451_abnormal_body_composition2.00004475
13MP0004510_myositis1.96986603
14MP0004858_abnormal_nervous_system1.95744706
15MP0010234_abnormal_vibrissa_follicle1.93680539
16MP0009840_abnormal_foam_cell1.93238470
17MP0003045_fibrosis1.93044516
18MP0000579_abnormal_nail_morphology1.92632175
19MP0000751_myopathy1.89900905
20MP0001348_abnormal_lacrimal_gland1.87833113
21MP0004084_abnormal_cardiac_muscle1.83904371
22MP0004264_abnormal_extraembryonic_tissu1.83494691
23MP0005503_abnormal_tendon_morphology1.81957321
24MP0010352_gastrointestinal_tract_polyps1.79835969
25MP0003279_aneurysm1.79560427
26MP0003303_peritoneal_inflammation1.76905551
27MP0005076_abnormal_cell_differentiation1.75497462
28MP0005666_abnormal_adipose_tissue1.65633424
29MP0004087_abnormal_muscle_fiber1.64488788
30MP0003828_pulmonary_edema1.63229088
31MP0001849_ear_inflammation1.62929118
32MP0004947_skin_inflammation1.62015517
33MP0003191_abnormal_cellular_cholesterol1.59429092
34MP0001216_abnormal_epidermal_layer1.57319668
35MP0005375_adipose_tissue_phenotype1.52757052
36MP0005023_abnormal_wound_healing1.48835121
37MP0002295_abnormal_pulmonary_circulatio1.48791902
38MP0000762_abnormal_tongue_morphology1.47923044
39MP0004130_abnormal_muscle_cell1.46364962
40MP0003300_gastrointestinal_ulcer1.43661822
41MP0005058_abnormal_lysosome_morphology1.39617443
42MP0005257_abnormal_intraocular_pressure1.39587125
43MP0006138_congestive_heart_failure1.38951533
44MP0010630_abnormal_cardiac_muscle1.35542978
45MP0008260_abnormal_autophagy1.35222239
46MP0001299_abnormal_eye_distance/1.34165732
47MP0000003_abnormal_adipose_tissue1.33179625
48MP0000750_abnormal_muscle_regeneration1.32680428
49MP0003329_amyloid_beta_deposits1.30844695
50MP0008004_abnormal_stomach_pH1.30640485
51MP0004859_abnormal_synaptic_plasticity1.29812615
52MP0000767_abnormal_smooth_muscle1.28690874
53MP0005501_abnormal_skin_physiology1.28654057
54MP0003941_abnormal_skin_development1.28562353
55MP0000534_abnormal_ureter_morphology1.27476736
56MP0004233_abnormal_muscle_weight1.27068421
57MP0000569_abnormal_digit_pigmentation1.26851282
58MP0003385_abnormal_body_wall1.22703186
59MP0010368_abnormal_lymphatic_system1.22208579
60MP0002254_reproductive_system_inflammat1.22183104
61MP0002168_other_aberrant_phenotype1.20741335
62MP0000537_abnormal_urethra_morphology1.20679417
63MP0009384_cardiac_valve_regurgitation1.20610339
64MP0000467_abnormal_esophagus_morphology1.20479324
65MP0008775_abnormal_heart_ventricle1.16457488
66MP0002877_abnormal_melanocyte_morpholog1.15561446
67MP0005670_abnormal_white_adipose1.13523912
68MP0003115_abnormal_respiratory_system1.12401204
69MP0005621_abnormal_cell_physiology1.12071995
70MP0004782_abnormal_surfactant_physiolog1.11713170
71MP0005330_cardiomyopathy1.11122322
72MP0000920_abnormal_myelination1.10978211
73MP0003950_abnormal_plasma_membrane1.09686949
74MP0003453_abnormal_keratinocyte_physiol1.07007006
75MP0001915_intracranial_hemorrhage1.06693622
76MP0002098_abnormal_vibrissa_morphology1.06388621
77MP0000858_altered_metastatic_potential1.03914759
78MP0000604_amyloidosis1.02684134
79MP0005248_abnormal_Harderian_gland1.02256181
80MP0002896_abnormal_bone_mineralization1.01132255
81MP0005508_abnormal_skeleton_morphology1.00398665
82MP0002925_abnormal_cardiovascular_devel1.00023961
83MP0004381_abnormal_hair_follicle0.99569330
84MP0000383_abnormal_hair_follicle0.98901580
85MP0004036_abnormal_muscle_relaxation0.98790689
86MP0002108_abnormal_muscle_morphology0.97324221
87MP0002089_abnormal_postnatal_growth/wei0.97198688
88MP0000759_abnormal_skeletal_muscle0.96956306
89MP0003634_abnormal_glial_cell0.96730832
90MP0002972_abnormal_cardiac_muscle0.96623748
91MP0003448_altered_tumor_morphology0.95897670
92MP0005164_abnormal_response_to0.95243178
93MP0001544_abnormal_cardiovascular_syste0.94779524
94MP0005385_cardiovascular_system_phenoty0.94779524
95MP0001614_abnormal_blood_vessel0.92248018
96MP0000377_abnormal_hair_follicle0.92128573
97MP0002128_abnormal_blood_circulation0.91981933
98MP0003690_abnormal_glial_cell0.91708329
99MP0000678_abnormal_parathyroid_gland0.90941910
100MP0010771_integument_phenotype0.90236682
101MP0000428_abnormal_craniofacial_morphol0.90063258
102MP0003172_abnormal_lysosome_physiology0.89733335
103MP0002086_abnormal_extraembryonic_tissu0.88408805
104MP0001243_abnormal_dermal_layer0.87658298
105MP0003436_decreased_susceptibility_to0.87490341
106MP0002060_abnormal_skin_morphology0.85794045
107MP0009931_abnormal_skin_appearance0.84959934
108MP0000747_muscle_weakness0.84903994
109MP0002837_dystrophic_cardiac_calcinosis0.84615803
110MP0002269_muscular_atrophy0.84615793
111MP0005167_abnormal_blood-brain_barrier0.83684559
112MP0005620_abnormal_muscle_contractility0.83605265
113MP0009278_abnormal_bone_marrow0.83282062
114MP0000013_abnormal_adipose_tissue0.83265533
115MP0000627_abnormal_mammary_gland0.83257389
116MP0004808_abnormal_hematopoietic_stem0.81197506
117MP0002332_abnormal_exercise_endurance0.80630871
118MP0010030_abnormal_orbit_morphology0.80080617
119MP0002282_abnormal_trachea_morphology0.79261177
120MP0002106_abnormal_muscle_physiology0.78680812
121MP0009780_abnormal_chondrocyte_physiolo0.77687017
122MP0002090_abnormal_vision0.76796676
123MP0001879_abnormal_lymphatic_vessel0.75995077
124MP0009053_abnormal_anal_canal0.75840589
125MP0001851_eye_inflammation0.75777523
126MP0005410_abnormal_fertilization0.75064413
127MP0003942_abnormal_urinary_system0.73787865
128* MP0002998_abnormal_bone_remodeling0.73071924
129MP0000566_synostosis0.73071164
130MP0004270_analgesia0.72481810
131MP0005369_muscle_phenotype0.71946393
132MP0000266_abnormal_heart_morphology0.71600172
133MP0008961_abnormal_basal_metabolism0.71009344
134MP0002796_impaired_skin_barrier0.70946179
135MP0000749_muscle_degeneration0.70336538
136MP0003221_abnormal_cardiomyocyte_apopto0.70168553
137MP0010678_abnormal_skin_adnexa0.69185359
138MP0002234_abnormal_pharynx_morphology0.67496550
139MP0003075_altered_response_to0.67132994
140MP0003984_embryonic_growth_retardation0.64525665
141MP0001730_embryonic_growth_arrest0.63631367

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.65231648
2Premature rupture of membranes (HP:0001788)4.60831459
3Shallow orbits (HP:0000586)4.32266246
4Cerebral aneurysm (HP:0004944)4.22753491
5Broad metatarsal (HP:0001783)3.35516150
6Ankle contracture (HP:0006466)3.27599387
7Atrophic scars (HP:0001075)3.17713894
8Peritonitis (HP:0002586)3.07411406
9Aortic dissection (HP:0002647)3.05592757
10Increased connective tissue (HP:0009025)3.02892902
11Broad face (HP:0000283)3.01734995
12Distal upper limb amyotrophy (HP:0007149)2.93698806
13Upper limb amyotrophy (HP:0009129)2.93698806
14Mitral valve prolapse (HP:0001634)2.93395211
15Hyporeflexia of lower limbs (HP:0002600)2.90134661
16Difficulty running (HP:0009046)2.89087319
17Aortic aneurysm (HP:0004942)2.86647072
18Thick nail (HP:0001805)2.82961498
19Dilatation of the ascending aorta (HP:0005111)2.76473812
20Bladder diverticulum (HP:0000015)2.67304666
21Scapular winging (HP:0003691)2.64328920
22Flat acetabular roof (HP:0003180)2.57490960
23Aneurysm (HP:0002617)2.52277088
24Genu recurvatum (HP:0002816)2.50361123
25Difficulty climbing stairs (HP:0003551)2.49927018
26Muscle fiber splitting (HP:0003555)2.47544609
27Cerebral inclusion bodies (HP:0100314)2.45326899
28Arterial tortuosity (HP:0005116)2.43291471
29Achilles tendon contracture (HP:0001771)2.43270884
30Vascular tortuosity (HP:0004948)2.42486007
31Increased variability in muscle fiber diameter (HP:0003557)2.41611029
32Fragile skin (HP:0001030)2.35352037
33Buphthalmos (HP:0000557)2.34874553
34Spinal rigidity (HP:0003306)2.34621776
35Ankyloglossia (HP:0010296)2.32123634
36Hand muscle atrophy (HP:0009130)2.30753648
37Type 1 muscle fiber predominance (HP:0003803)2.28970754
38Right ventricular cardiomyopathy (HP:0011663)2.28193484
39Interstitial pulmonary disease (HP:0006530)2.27469189
40Neurofibrillary tangles (HP:0002185)2.26486246
41Obstructive sleep apnea (HP:0002870)2.23727748
42Lower limb amyotrophy (HP:0007210)2.22110297
43Abnormality of the distal phalanx of the thumb (HP:0009617)2.20737140
44Distal lower limb muscle weakness (HP:0009053)2.20032282
45Abnormality of the Achilles tendon (HP:0005109)2.18122158
46Natal tooth (HP:0000695)2.17541025
47Syringomyelia (HP:0003396)2.17347556
48Spinal cord lesions (HP:0100561)2.17347556
49Cervical subluxation (HP:0003308)2.16541001
50Ulnar bowing (HP:0003031)2.13243724
51Lymphangioma (HP:0100764)2.09686935
52Wrist flexion contracture (HP:0001239)2.09332780
53Hyperextensible skin (HP:0000974)2.08692099
54Abnormality of nail color (HP:0100643)2.07341884
55Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.07209794
56Osteolytic defects of the hand bones (HP:0009699)2.06893646
57Osteolytic defects of the phalanges of the hand (HP:0009771)2.06893646
58Advanced eruption of teeth (HP:0006288)2.05908025
59Vertebral arch anomaly (HP:0008438)2.05394543
60Abnormality of dentin (HP:0010299)2.05085226
61Bronchomalacia (HP:0002780)2.04304664
62Distal lower limb amyotrophy (HP:0008944)2.03932931
63Abnormality of skeletal muscle fiber size (HP:0012084)2.03828181
64Abnormality of oral frenula (HP:0000190)2.03685135
65Absent frontal sinuses (HP:0002688)2.03630906
66Spondylolisthesis (HP:0003302)2.01910992
67Mildly elevated creatine phosphokinase (HP:0008180)2.01866306
68Lip pit (HP:0100267)2.01595333
69Asymmetry of the thorax (HP:0001555)2.00717368
70Sudden death (HP:0001699)1.99812863
71Deviation of the hallux (HP:0010051)1.99795834
72Blue sclerae (HP:0000592)1.96559870
73Arnold-Chiari malformation (HP:0002308)1.96276309
74Hallux valgus (HP:0001822)1.94564877
75Macroorchidism (HP:0000053)1.94377773
76Thin bony cortex (HP:0002753)1.94340860
77Turricephaly (HP:0000262)1.93576546
78Camptodactyly of toe (HP:0001836)1.92923546
79Disproportionate tall stature (HP:0001519)1.92097431
80Wormian bones (HP:0002645)1.90930813
81Alopecia of scalp (HP:0002293)1.90910272
82Abnormal ossification of hand bones (HP:0005921)1.89135145
83Subacute progressive viral hepatitis (HP:0006572)1.88834598
84Coronal craniosynostosis (HP:0004440)1.88704970
85Frequent falls (HP:0002359)1.88574973
86Abnormality of the lower motor neuron (HP:0002366)1.88071772
87Hypoplasia of dental enamel (HP:0006297)1.87627368
88Long palpebral fissure (HP:0000637)1.86358487
89Plantar hyperkeratosis (HP:0007556)1.85830582
90Supranuclear gaze palsy (HP:0000605)1.85343902
91Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.85011510
92Hyperacusis (HP:0010780)1.84874834
93Soft skin (HP:0000977)1.82345650
94Nail dystrophy (HP:0008404)1.82230147
95Mitral regurgitation (HP:0001653)1.79829809
96Myocardial infarction (HP:0001658)1.79329352
97Mitral stenosis (HP:0001718)1.78914814
98Termporal pattern (HP:0011008)1.75993055
99Insidious onset (HP:0003587)1.75993055
100Wide anterior fontanel (HP:0000260)1.75686695
101Heterotopia (HP:0002282)1.74861263
102Abnormality of the distal phalanges of the toes (HP:0010182)1.72584533
103Short nail (HP:0001799)1.72473197
104Milia (HP:0001056)1.72162834
105Round ear (HP:0100830)1.72112884
106Elbow flexion contracture (HP:0002987)1.72092262
107Bowing of the arm (HP:0006488)1.71536428
108Bowed forearm bones (HP:0003956)1.71536428
109Micronodular cirrhosis (HP:0001413)1.70912798
110Vertebral compression fractures (HP:0002953)1.70876549
111Bowel diverticulosis (HP:0005222)1.70393420
112Aplasia cutis congenita (HP:0001057)1.69984708
113Exercise-induced muscle cramps (HP:0003710)1.69249498
114Striae distensae (HP:0001065)1.68894006
115Abnormality of the peritoneum (HP:0002585)1.68528077
116Centrally nucleated skeletal muscle fibers (HP:0003687)1.68461633
117Hammertoe (HP:0001765)1.68009065
118Overgrowth (HP:0001548)1.68005423
119Abnormality of carpal bone ossification (HP:0006257)1.67595716
120Abnormality of the fingertips (HP:0001211)1.66948244
121Bundle branch block (HP:0011710)1.66920308
122Selective tooth agenesis (HP:0001592)1.66860956
123Dislocated radial head (HP:0003083)1.66277689
124Abnormality of the thoracic spine (HP:0100711)1.66014865
125Joint laxity (HP:0001388)1.65240776
126Long eyelashes (HP:0000527)1.64959286
127Onycholysis (HP:0001806)1.64745213
128Radial bowing (HP:0002986)1.64044773
129Insomnia (HP:0100785)1.61508059
130Abnormality of the calf musculature (HP:0001430)1.60032028
131Fragile nails (HP:0001808)1.59805481
132Fibroma (HP:0010614)1.59353769
133Onion bulb formation (HP:0003383)1.59153267
134EMG: myopathic abnormalities (HP:0003458)1.58418384
135Esophageal varix (HP:0002040)1.58232703
136Ventricular tachycardia (HP:0004756)1.58118304
137Germ cell neoplasia (HP:0100728)1.57994274
138Increased density of long bones (HP:0006392)1.57595362
139Follicular hyperkeratosis (HP:0007502)1.57214731
140Abnormality of the salivary glands (HP:0010286)1.56997235
141Coarse hair (HP:0002208)1.56901766
142Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.56634910
143Cardiovascular calcification (HP:0011915)1.56540077
144Bell-shaped thorax (HP:0001591)1.55677906
145Rapidly progressive (HP:0003678)1.55149975
146Enlarged penis (HP:0000040)1.54438999
147Renovascular hypertension (HP:0100817)1.54403996
148Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.54383105
149Short 4th metacarpal (HP:0010044)1.54383105
150Venous abnormality (HP:0002624)1.54161059
151Infantile muscular hypotonia (HP:0008947)1.53812889
152Hemorrhage of the eye (HP:0011885)1.53287684
153Cubitus valgus (HP:0002967)1.53193052

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.86931864
2TTN3.08023010
3PKN22.81750948
4IRAK32.76013824
5PRPF4B2.65639421
6ICK2.39415521
7EPHB12.27130415
8DDR22.26718480
9TYRO32.16401430
10DMPK2.15519139
11PDGFRA2.09965156
12RIPK12.03178615
13BMX2.01592735
14LATS11.94802815
15SMG11.94106239
16MAP3K91.92273670
17LATS21.87391506
18PRKD31.84437818
19PAK61.83540767
20EEF2K1.75522043
21MAP3K101.62800692
22EPHA21.60837369
23PTK61.56752433
24KSR21.53529192
25MAP3K31.49082330
26PTK21.39533499
27MET1.37687267
28TAOK11.36306359
29BRD41.35155276
30PDK31.32976819
31PDK41.32976819
32EPHB21.31310428
33PAK31.31108307
34RET1.30880096
35PDGFRB1.30539637
36MAP3K61.22537019
37PAK21.22478119
38NTRK11.20865596
39SIK11.17593577
40PTK2B1.17120371
41CAMK1G1.15554793
42MELK1.12189753
43MTOR1.05769632
44CDK121.04800053
45CAMK1D1.04601650
46ALK1.01954164
47TGFBR21.01869430
48MARK10.99825341
49FER0.98230078
50SIK30.97846206
51STK390.96084397
52PAK40.93597891
53TESK10.91747477
54PDK20.90960773
55MAP3K140.90112505
56AKT30.89572698
57LRRK20.88789642
58FGFR40.87795869
59IRAK20.87111950
60FGFR20.87044851
61WNK10.85941738
62MAP2K30.84504005
63ROCK20.82825255
64ROCK10.81844506
65MOS0.80980690
66SGK30.80208133
67MARK20.79305480
68STK380.78913590
69NEK60.78582514
70STK240.77934935
71PRKCH0.77859178
72ERN10.77443300
73MARK30.77004619
74FGR0.75281450
75ARAF0.71348541
76MST1R0.70924876
77STK30.70373102
78RPS6KA20.69971658
79PRKD10.69298446
80FGFR10.69224243
81ILK0.68875997
82TRPM70.65197578
83JAK10.64769100
84PHKG10.64486503
85PHKG20.64486503
86ZAP700.64092785
87CSK0.61971962
88LMTK20.61375538
89MAP2K10.60519958
90MAP3K70.60224873
91LIMK10.60182519
92PDPK10.59924605
93MAP3K130.59787222
94CAMKK10.59030351
95ERBB40.58782065
96RPS6KB20.58573209
97STK110.58218642
98EPHA30.57984419
99MAP3K20.57806866
100PKN10.56969656
101CDK90.56546376
102TBK10.54618233
103MYLK0.53273680
104TAOK20.50595463
105MAP3K80.50027693
106INSR0.49812178
107EPHA40.49758587
108KSR10.49525575
109FYN0.46887422
110EGFR0.46884219
111MAPK110.46687699
112CLK10.46644859
113PRKD20.46523199
114IRAK40.44843862
115SIK20.44767212
116CDC42BPA0.43079510
117SCYL20.42278397
118GSK3A0.41927480
119SRC0.41838786
120STK100.41290802
121MAP3K10.41252535
122BRAF0.41104744
123CHUK0.40376524
124PDK10.40095496
125CDK140.40006775
126NME20.39995093
127CDK50.39525469
128DYRK1B0.39274732
129CDK60.38937071
130PRKG20.38460820
131MAPKAPK30.37720125
132CDK150.37372075
133HIPK20.36422429
134FGFR30.36202324
135MAPK100.31537535
136SGK2230.28835011
137SGK4940.28835011
138JAK30.28187025

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045121.89631408
2Focal adhesion_Homo sapiens_hsa045101.88293469
3Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.82810919
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.79967690
5Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.77357753
6Dilated cardiomyopathy_Homo sapiens_hsa054141.72094712
7Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.71039406
8Proteoglycans in cancer_Homo sapiens_hsa052051.64668495
9Adherens junction_Homo sapiens_hsa045201.63231223
10Other glycan degradation_Homo sapiens_hsa005111.59134302
11Amoebiasis_Homo sapiens_hsa051461.51877512
12Renal cell carcinoma_Homo sapiens_hsa052111.51102610
13Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.50026878
14Thyroid cancer_Homo sapiens_hsa052161.48633256
15Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.44810148
16Chronic myeloid leukemia_Homo sapiens_hsa052201.43873263
17Axon guidance_Homo sapiens_hsa043601.42741481
18AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.42635613
19Dorso-ventral axis formation_Homo sapiens_hsa043201.41751198
20Viral myocarditis_Homo sapiens_hsa054161.41616116
21Small cell lung cancer_Homo sapiens_hsa052221.35824817
22Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.24399471
23Hippo signaling pathway_Homo sapiens_hsa043901.24184624
24Regulation of actin cytoskeleton_Homo sapiens_hsa048101.22670155
25VEGF signaling pathway_Homo sapiens_hsa043701.21643283
26Tight junction_Homo sapiens_hsa045301.19960098
27Glioma_Homo sapiens_hsa052141.19206730
28Toxoplasmosis_Homo sapiens_hsa051451.16532702
29Phosphatidylinositol signaling system_Homo sapiens_hsa040701.12922880
30Endometrial cancer_Homo sapiens_hsa052131.11538039
31Inositol phosphate metabolism_Homo sapiens_hsa005621.11395905
32Leukocyte transendothelial migration_Homo sapiens_hsa046701.10458152
33Hepatitis C_Homo sapiens_hsa051601.10011806
34Nitrogen metabolism_Homo sapiens_hsa009101.07115898
35Pancreatic cancer_Homo sapiens_hsa052121.06725614
36Adipocytokine signaling pathway_Homo sapiens_hsa049201.06535706
37Osteoclast differentiation_Homo sapiens_hsa043801.05738891
38ErbB signaling pathway_Homo sapiens_hsa040121.05157216
39Estrogen signaling pathway_Homo sapiens_hsa049151.04861933
40mTOR signaling pathway_Homo sapiens_hsa041501.02175952
41Phospholipase D signaling pathway_Homo sapiens_hsa040721.01898400
42Fatty acid biosynthesis_Homo sapiens_hsa000611.01569318
43* Endocytosis_Homo sapiens_hsa041441.01355852
44MicroRNAs in cancer_Homo sapiens_hsa052061.00730836
45Hepatitis B_Homo sapiens_hsa051611.00618202
46Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.99255780
47Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.98016444
48Neurotrophin signaling pathway_Homo sapiens_hsa047220.95446276
49FoxO signaling pathway_Homo sapiens_hsa040680.95435305
50Rap1 signaling pathway_Homo sapiens_hsa040150.94999119
51TNF signaling pathway_Homo sapiens_hsa046680.94368595
52Glycosaminoglycan degradation_Homo sapiens_hsa005310.93579130
53Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.93460502
54GnRH signaling pathway_Homo sapiens_hsa049120.91940946
55Bladder cancer_Homo sapiens_hsa052190.91399627
56Platelet activation_Homo sapiens_hsa046110.91197306
57Central carbon metabolism in cancer_Homo sapiens_hsa052300.90469110
58Insulin resistance_Homo sapiens_hsa049310.90357277
59Type II diabetes mellitus_Homo sapiens_hsa049300.89242573
60Shigellosis_Homo sapiens_hsa051310.89105436
61Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.87814552
62Thyroid hormone signaling pathway_Homo sapiens_hsa049190.87366001
63Salmonella infection_Homo sapiens_hsa051320.84981863
64Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.84921884
65Influenza A_Homo sapiens_hsa051640.84246282
66Colorectal cancer_Homo sapiens_hsa052100.83937624
67MAPK signaling pathway_Homo sapiens_hsa040100.83250208
68Oxytocin signaling pathway_Homo sapiens_hsa049210.82736835
69Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.82509440
70Acute myeloid leukemia_Homo sapiens_hsa052210.80770922
71Gap junction_Homo sapiens_hsa045400.80302751
72Non-small cell lung cancer_Homo sapiens_hsa052230.79891905
73Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.79386959
74Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.79147510
75Sphingolipid metabolism_Homo sapiens_hsa006000.78910560
76AMPK signaling pathway_Homo sapiens_hsa041520.78020704
77Longevity regulating pathway - mammal_Homo sapiens_hsa042110.77606212
78Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.76981287
79Ras signaling pathway_Homo sapiens_hsa040140.75429432
80* TGF-beta signaling pathway_Homo sapiens_hsa043500.74036105
81Renin secretion_Homo sapiens_hsa049240.73298247
82Prion diseases_Homo sapiens_hsa050200.73110575
83Circadian rhythm_Homo sapiens_hsa047100.72657390
84HIF-1 signaling pathway_Homo sapiens_hsa040660.72069104
85Prolactin signaling pathway_Homo sapiens_hsa049170.71819683
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.71534044
87PI3K-Akt signaling pathway_Homo sapiens_hsa041510.71303989
88Basal cell carcinoma_Homo sapiens_hsa052170.71043155
89Pathways in cancer_Homo sapiens_hsa052000.70275552
90Prostate cancer_Homo sapiens_hsa052150.70139882
91Malaria_Homo sapiens_hsa051440.70047905
92cGMP-PKG signaling pathway_Homo sapiens_hsa040220.69340760
93PPAR signaling pathway_Homo sapiens_hsa033200.68914184
94Insulin signaling pathway_Homo sapiens_hsa049100.68453941
95Viral carcinogenesis_Homo sapiens_hsa052030.68377949
96Cholinergic synapse_Homo sapiens_hsa047250.68289856
97Notch signaling pathway_Homo sapiens_hsa043300.67759904
98B cell receptor signaling pathway_Homo sapiens_hsa046620.67605266
99Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.67121773
100Gastric acid secretion_Homo sapiens_hsa049710.64648276
101Vascular smooth muscle contraction_Homo sapiens_hsa042700.63893699
102T cell receptor signaling pathway_Homo sapiens_hsa046600.63024703
103Hedgehog signaling pathway_Homo sapiens_hsa043400.63001508
104Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.62020380
105Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.61861036
106Long-term potentiation_Homo sapiens_hsa047200.61739551
107Chemokine signaling pathway_Homo sapiens_hsa040620.61250222
108Apoptosis_Homo sapiens_hsa042100.60324277
109Leishmaniasis_Homo sapiens_hsa051400.60266929
110Melanogenesis_Homo sapiens_hsa049160.59872766
111Choline metabolism in cancer_Homo sapiens_hsa052310.59857739
112NF-kappa B signaling pathway_Homo sapiens_hsa040640.59124918
113Measles_Homo sapiens_hsa051620.58876464
114Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57019890
115RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.56797428
116Salivary secretion_Homo sapiens_hsa049700.56316193
117Toll-like receptor signaling pathway_Homo sapiens_hsa046200.56030573
118Protein digestion and absorption_Homo sapiens_hsa049740.55649893
119Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55178766
120Melanoma_Homo sapiens_hsa052180.55086843
121Jak-STAT signaling pathway_Homo sapiens_hsa046300.54837391
122Lysine degradation_Homo sapiens_hsa003100.52856607
123Pertussis_Homo sapiens_hsa051330.51898147

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