SMURF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1substrate-dependent cell migration (GO:0006929)4.54028104
2cellular response to vitamin D (GO:0071305)4.15043776
3wound healing, spreading of epidermal cells (GO:0035313)4.04486647
4cellular response to vitamin (GO:0071295)4.02680026
5hemidesmosome assembly (GO:0031581)3.92025961
6hypotonic response (GO:0006971)3.80097530
7hippo signaling (GO:0035329)3.76757918
8positive regulation of fatty acid oxidation (GO:0046321)3.49108327
9kidney mesenchyme development (GO:0072074)3.48221967
10regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.44658864
11sprouting angiogenesis (GO:0002040)3.34665259
12type B pancreatic cell proliferation (GO:0044342)3.33053757
13growth hormone receptor signaling pathway (GO:0060396)3.26130033
14positive regulation of fatty acid beta-oxidation (GO:0032000)3.25801188
15membrane raft organization (GO:0031579)3.23410214
16dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.22580275
17negative regulation of fibrinolysis (GO:0051918)3.19217660
18cell adhesion mediated by integrin (GO:0033627)3.16172316
19cytoplasmic mRNA processing body assembly (GO:0033962)3.15841344
20response to gravity (GO:0009629)3.15608210
21smooth muscle tissue development (GO:0048745)3.14608395
22muscle cell migration (GO:0014812)3.13227114
23sequestering of extracellular ligand from receptor (GO:0035581)3.09083068
24wound healing, spreading of cells (GO:0044319)3.07951171
25negative regulation of nitric-oxide synthase activity (GO:0051001)3.07724081
26regulation of hippo signaling (GO:0035330)3.07581612
27heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.05009868
28mammary gland epithelial cell proliferation (GO:0033598)3.04541642
29negative regulation of cardiac muscle tissue development (GO:0055026)3.03945183
30cell migration involved in sprouting angiogenesis (GO:0002042)3.02512477
31lymph vessel development (GO:0001945)3.01858802
32midgut development (GO:0007494)3.00639774
33mitotic sister chromatid cohesion (GO:0007064)2.98051153
34negative regulation of stem cell proliferation (GO:2000647)2.96402671
35embryonic retina morphogenesis in camera-type eye (GO:0060059)2.95757835
36vascular endothelial growth factor signaling pathway (GO:0038084)2.94689356
37regulation of glomerular filtration (GO:0003093)2.93851884
38positive regulation of hormone biosynthetic process (GO:0046886)2.93555685
39endothelial cell morphogenesis (GO:0001886)2.93306619
40pericardium development (GO:0060039)2.91892873
41negative regulation of anoikis (GO:2000811)2.91665849
42regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.91339834
43UDP-N-acetylglucosamine metabolic process (GO:0006047)2.90496785
44protein heterotrimerization (GO:0070208)2.89254060
45lung vasculature development (GO:0060426)2.88298706
46regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.87912308
47blood vessel maturation (GO:0001955)2.87294186
48cell-substrate junction assembly (GO:0007044)2.86893729
49coronary vasculature morphogenesis (GO:0060977)2.86115153
50substrate adhesion-dependent cell spreading (GO:0034446)2.86094771
51negative regulation of axon extension involved in axon guidance (GO:0048843)2.84961290
52SMAD protein complex assembly (GO:0007183)2.82135991
53cytoskeleton-dependent cytokinesis (GO:0061640)2.82076001
54pharyngeal system development (GO:0060037)2.82048076
55actin filament depolymerization (GO:0030042)2.79711085
56positive regulation of glycogen biosynthetic process (GO:0045725)2.78984754
57collagen fibril organization (GO:0030199)2.78353484
58retina vasculature morphogenesis in camera-type eye (GO:0061299)2.77242466
59negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.75598064
60basement membrane organization (GO:0071711)2.74928055
61regulation of transforming growth factor beta2 production (GO:0032909)2.74338474
62mitotic cytokinesis (GO:0000281)2.73069175
63endocardial cushion development (GO:0003197)2.72346508
64cellular response to growth hormone stimulus (GO:0071378)2.72196589
65positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-2.71280903
66paraxial mesoderm development (GO:0048339)2.71050165
67insulin-like growth factor receptor signaling pathway (GO:0048009)2.70794974
68positive regulation of blood vessel endothelial cell migration (GO:0043536)2.70744539
69mesodermal cell differentiation (GO:0048333)2.70293972
70collagen metabolic process (GO:0032963)2.69925618
71lung lobe morphogenesis (GO:0060463)2.68916948
72barbed-end actin filament capping (GO:0051016)2.68266142
73epoxygenase P450 pathway (GO:0019373)2.67915122
74alpha-linolenic acid metabolic process (GO:0036109)2.66721962
75regulation of SMAD protein import into nucleus (GO:0060390)2.66721586
76metanephric mesenchyme development (GO:0072075)2.64186967
77nuclear pore complex assembly (GO:0051292)2.63682038
78regulation of fibrinolysis (GO:0051917)2.63322692
79regulation of keratinocyte proliferation (GO:0010837)2.59720092
80artery development (GO:0060840)2.58695688
81negative regulation of chondrocyte differentiation (GO:0032331)2.58307856
82regulation of fatty acid beta-oxidation (GO:0031998)2.58244734
83positive regulation of DNA-dependent DNA replication (GO:2000105)2.57656334
84lung morphogenesis (GO:0060425)2.56421211
85endodermal cell differentiation (GO:0035987)2.56147141
86chondrocyte proliferation (GO:0035988)2.55502893
87respiratory tube development (GO:0030323)2.52913219
88bone trabecula formation (GO:0060346)2.52902812
89collagen catabolic process (GO:0030574)2.51643042
90protein hydroxylation (GO:0018126)2.51187982
91regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.50773690
92keratinocyte proliferation (GO:0043616)2.49300033
93renal system development (GO:0072001)2.48383194
94positive regulation of cartilage development (GO:0061036)2.48134900
95negative regulation of vascular permeability (GO:0043116)2.48006444
96negative regulation of keratinocyte proliferation (GO:0010839)2.47550134
97blood vessel endothelial cell migration (GO:0043534)2.47133116
98positive regulation of cardiac muscle cell differentiation (GO:2000727)2.46950617
99negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.46843056
100positive regulation of osteoblast proliferation (GO:0033690)2.46556298
101negative regulation of axon guidance (GO:1902668)2.46344391
102peptidyl-glutamic acid carboxylation (GO:0017187)2.45656432
103protein carboxylation (GO:0018214)2.45656432
104multicellular organismal macromolecule metabolic process (GO:0044259)2.45516399
105positive regulation of epithelial to mesenchymal transition (GO:0010718)2.45360778
106regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.45030205
107regulation of transforming growth factor beta1 production (GO:0032908)2.44313500
108cranial suture morphogenesis (GO:0060363)2.44037273
109extracellular matrix disassembly (GO:0022617)2.42944849
110multicellular organismal metabolic process (GO:0044236)2.42930315
111positive regulation of endothelial cell apoptotic process (GO:2000353)2.42869662
112positive regulation of endothelial cell migration (GO:0010595)2.42304724
113regulation of plasminogen activation (GO:0010755)2.41198195
114cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.40418518
115positive regulation of glycogen metabolic process (GO:0070875)2.40113181
116positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)2.39661464
117lymphangiogenesis (GO:0001946)2.39011079
118ganglion development (GO:0061548)2.38707066
119membrane assembly (GO:0071709)2.38385259
120glomerular visceral epithelial cell development (GO:0072015)2.38267766
121cardiac epithelial to mesenchymal transition (GO:0060317)2.37969380
122multicellular organismal catabolic process (GO:0044243)2.37337552
123regulation of chondrocyte differentiation (GO:0032330)2.37110862
124regulation of metalloenzyme activity (GO:0048552)2.37008923
125negative regulation of cartilage development (GO:0061037)2.36902427
126response to magnesium ion (GO:0032026)2.36646588
127endothelial cell proliferation (GO:0001935)2.36635602
128regulation of cardioblast proliferation (GO:0003264)2.36548303
129regulation of secondary heart field cardioblast proliferation (GO:0003266)2.36548303
130axis elongation (GO:0003401)2.36164763
131dorsal/ventral axis specification (GO:0009950)2.35730524
132positive regulation of SMAD protein import into nucleus (GO:0060391)2.34796875
133renal filtration (GO:0097205)2.34302975
134genitalia morphogenesis (GO:0035112)2.33395688
135positive regulation of mesenchymal cell proliferation (GO:0002053)2.32110408
136regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.31767586
137regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.29141428
138regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.29072870
139positive regulation of focal adhesion assembly (GO:0051894)2.28122876
140positive regulation of cell junction assembly (GO:1901890)2.28122876
141camera-type eye morphogenesis (GO:0048593)2.27782874
142homocysteine metabolic process (GO:0050667)2.27771016
143regulation of protein activation cascade (GO:2000257)2.27467156
144erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.27290932
145L-phenylalanine catabolic process (GO:0006559)2.27290932
146regulation of cholesterol homeostasis (GO:2000188)2.26963475
147embryonic foregut morphogenesis (GO:0048617)2.26480911
148protein localization to cell surface (GO:0034394)2.26471791
149craniofacial suture morphogenesis (GO:0097094)2.25965153
150regulation of endothelial cell differentiation (GO:0045601)2.25288420
151positive regulation of catenin import into nucleus (GO:0035413)2.25077451
152face morphogenesis (GO:0060325)2.24728628
153positive regulation of adherens junction organization (GO:1903393)2.24674163
154skin morphogenesis (GO:0043589)2.24586092
155heart morphogenesis (GO:0003007)2.23490982
156fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.23442787
157mesenchymal-epithelial cell signaling (GO:0060638)2.23441231
158radial glial cell differentiation (GO:0060019)2.23158702
159gastrulation with mouth forming second (GO:0001702)2.21133308
160urea metabolic process (GO:0019627)2.21028311
161urea cycle (GO:0000050)2.21028311
162regulation of catenin import into nucleus (GO:0035412)2.20952838
163regulation of heart morphogenesis (GO:2000826)2.20406347
164protein localization to endosome (GO:0036010)2.19910994
165glomerular filtration (GO:0003094)2.19687934
166regulation of fatty acid oxidation (GO:0046320)2.19028392
167blood vessel morphogenesis (GO:0048514)2.17889836
168negative regulation of fatty acid transport (GO:2000192)2.17689705
169regulation of complement activation (GO:0030449)2.17585773
170artery morphogenesis (GO:0048844)2.17114882
171regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.17032534
172positive regulation of endothelial cell differentiation (GO:0045603)2.16558506
173hormone catabolic process (GO:0042447)2.16261701
174morphogenesis of an endothelium (GO:0003159)2.15464905

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.45178617
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.27637749
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.03588653
4STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.96319315
5LXR_22158963_ChIP-Seq_LIVER_Mouse2.81276766
6* RXR_22158963_ChIP-Seq_LIVER_Mouse2.72661029
7CLOCK_20551151_ChIP-Seq_293T_Human2.69430017
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.61934167
9CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.51678966
10RBPJ_22232070_ChIP-Seq_NCS_Mouse2.34457464
11PPARA_22158963_ChIP-Seq_LIVER_Mouse2.29038951
12ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.10896356
13JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.10253085
14* ZNF217_24962896_ChIP-Seq_MCF-7_Human2.09653514
15* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.09467468
16* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.09004932
17NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.08608895
18EP300_21415370_ChIP-Seq_HL-1_Mouse2.03876667
19TP63_17297297_ChIP-ChIP_HaCaT_Human2.03667130
20SMAD_19615063_ChIP-ChIP_OVARY_Human2.02255976
21* SALL1_21062744_ChIP-ChIP_HESCs_Human1.99225004
22EGR1_19374776_ChIP-ChIP_THP-1_Human1.97933086
23WT1_19549856_ChIP-ChIP_CCG9911_Human1.90000340
24ESR1_20079471_ChIP-ChIP_T-47D_Human1.89116502
25FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.87698990
26RARG_19884340_ChIP-ChIP_MEFs_Mouse1.84837213
27PPAR_26484153_Chip-Seq_NCI-H1993_Human1.84360544
28CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.82994459
29PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.82226643
30FOXO3_23340844_ChIP-Seq_DLD1_Human1.82150463
31SALL4_18804426_ChIP-ChIP_XEN_Mouse1.80860567
32BRD4_25478319_ChIP-Seq_HGPS_Human1.79215457
33* CJUN_26792858_Chip-Seq_BT549_Human1.75524290
34ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.66179168
35ESR2_21235772_ChIP-Seq_MCF-7_Human1.65470923
36CDX2_19796622_ChIP-Seq_MESCs_Mouse1.61038250
37* FOXA2_19822575_ChIP-Seq_HepG2_Human1.60123890
38EGR1_23403033_ChIP-Seq_LIVER_Mouse1.59242880
39FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.58159361
40TP53_16413492_ChIP-PET_HCT116_Human1.54161930
41MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.51479717
42ESR1_21235772_ChIP-Seq_MCF-7_Human1.50592214
43EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.50187544
44TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.49570486
45AR_21909140_ChIP-Seq_LNCAP_Human1.46798286
46ISL1_27105846_Chip-Seq_CPCs_Mouse1.45910165
47TP53_22127205_ChIP-Seq_IMR90_Human1.45807651
48ZFP57_27257070_Chip-Seq_ESCs_Mouse1.45300323
49TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.44833593
50HIF1A_21447827_ChIP-Seq_MCF-7_Human1.44799554
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.42392695
52TCF4_18268006_ChIP-ChIP_LS174T_Human1.42207328
53NRF2_20460467_ChIP-Seq_MEFs_Mouse1.41747377
54NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.41747377
55NFIB_24661679_ChIP-Seq_LUNG_Mouse1.39778552
56FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.39621282
57AHR_22903824_ChIP-Seq_MCF-7_Human1.38224213
58SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.38116440
59SOX9_24532713_ChIP-Seq_HFSC_Mouse1.38067767
60AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.37187996
61* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.35752350
62GATA2_21666600_ChIP-Seq_HMVEC_Human1.34667417
63* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.34491491
64* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.34350488
65* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.34350488
66* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.32267504
67PIAS1_25552417_ChIP-Seq_VCAP_Human1.30272208
68DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.30028313
69ELK1_19687146_ChIP-ChIP_HELA_Human1.29114779
70FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.29062338
71HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.28626115
72SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27628541
73TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27355034
74UBF1/2_26484160_Chip-Seq_HMECs_Human1.26401367
75TBX20_22080862_ChIP-Seq_HEART_Mouse1.26305504
76TBX20_22328084_ChIP-Seq_HEART_Mouse1.26305504
77BCAT_22108803_ChIP-Seq_LS180_Human1.25647451
78* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23419547
79FOXM1_26456572_ChIP-Seq_MCF-7_Human1.23383626
80PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.23277443
81POU3F2_20337985_ChIP-ChIP_501MEL_Human1.22031327
82FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.21156430
83* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.17502314
84PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.17168959
85FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.16630339
86ARNT_22903824_ChIP-Seq_MCF-7_Human1.16558276
87ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.16270065
88* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.16252568
89NR3C1_21868756_ChIP-Seq_MCF10A_Human1.16140633
90* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.15110663
91* ATF3_27146783_Chip-Seq_COLON_Human1.14683795
92STAT6_21828071_ChIP-Seq_BEAS2B_Human1.14166007
93HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.12962390
94AR_21572438_ChIP-Seq_LNCaP_Human1.11010961
95SMAD4_21799915_ChIP-Seq_A2780_Human1.08718830
96TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.08368206
97FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.07406181
98SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.07356157
99ELK3_25401928_ChIP-Seq_HUVEC_Human1.05365892
100* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.04274819
101TBX3_20139965_ChIP-Seq_ESCs_Mouse1.03811485
102BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.03486042
103TP53_18474530_ChIP-ChIP_U2OS_Human1.03277015
104ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.02777811
105BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.02391568
106SOX2_27498859_Chip-Seq_STOMACH_Mouse1.02272050
107TBX3_20139965_ChIP-Seq_MESCs_Mouse1.02171720
108GATA4_25053715_ChIP-Seq_YYC3_Human1.01754780
109SOX17_20123909_ChIP-Seq_XEN_Mouse1.01155676
110CDX2_22108803_ChIP-Seq_LS180_Human1.00791311
111TP63_23658742_ChIP-Seq_EP156T_Human1.00703112
112CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.00624897
113* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.00587001
114GBX2_23144817_ChIP-Seq_PC3_Human1.00466547
115SOX2_20726797_ChIP-Seq_SW620_Human0.99894312
116TP53_23651856_ChIP-Seq_MEFs_Mouse0.99519393
117FOXM1_23109430_ChIP-Seq_U2OS_Human0.98404121
118ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.98104190
119FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.97972815
120Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.97856454
121FOXA1_25552417_ChIP-Seq_VCAP_Human0.97603048
122NFI_21473784_ChIP-Seq_ESCs_Mouse0.97115204
123CTNNB1_20460455_ChIP-Seq_HCT116_Human0.96584467
124ELK1_22589737_ChIP-Seq_MCF10A_Human0.96011121
125* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.95458831
126NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.94396630
127RXR_22108803_ChIP-Seq_LS180_Human0.94169895
128AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.92513481
129* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.92124571
130POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.91675628
131EWS_26573619_Chip-Seq_HEK293_Human0.90202225
132PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human0.89956951
133FUS_26573619_Chip-Seq_HEK293_Human0.89744631
134NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.89632245
135MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.88820809
136TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.88703378

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.07704968
2MP0003950_abnormal_plasma_membrane3.94973068
3MP0003705_abnormal_hypodermis_morpholog3.72846266
4MP0010368_abnormal_lymphatic_system3.09394977
5MP0005503_abnormal_tendon_morphology2.91363448
6MP0005275_abnormal_skin_tensile2.75672346
7MP0004272_abnormal_basement_membrane2.72528312
8MP0002139_abnormal_hepatobiliary_system2.66154996
9MP0005360_urolithiasis2.58781000
10MP0009384_cardiac_valve_regurgitation2.49706942
11MP0003252_abnormal_bile_duct2.23624474
12MP0005365_abnormal_bile_salt2.13328653
13MP0009053_abnormal_anal_canal2.13256954
14MP0001542_abnormal_bone_strength2.05438794
15MP0010352_gastrointestinal_tract_polyps1.93910588
16MP0003300_gastrointestinal_ulcer1.88132398
17MP0001879_abnormal_lymphatic_vessel1.83765407
18MP0000733_abnormal_muscle_development1.79066466
19MP0005085_abnormal_gallbladder_physiolo1.68264101
20MP0000762_abnormal_tongue_morphology1.65763563
21MP0010234_abnormal_vibrissa_follicle1.60020889
22MP0000537_abnormal_urethra_morphology1.59722437
23MP0003566_abnormal_cell_adhesion1.53978898
24MP0010030_abnormal_orbit_morphology1.50247686
25MP0005023_abnormal_wound_healing1.50040010
26MP0005076_abnormal_cell_differentiation1.48245090
27MP0003279_aneurysm1.48136124
28MP0003937_abnormal_limbs/digits/tail_de1.44765054
29MP0000767_abnormal_smooth_muscle1.43375966
30MP0001958_emphysema1.42788656
31MP0002177_abnormal_outer_ear1.41686360
32MP0005248_abnormal_Harderian_gland1.41024070
33MP0005595_abnormal_vascular_smooth1.38946329
34MP0005187_abnormal_penis_morphology1.38938187
35MP0009697_abnormal_copulation1.37915626
36MP0005623_abnormal_meninges_morphology1.37335345
37MP0002060_abnormal_skin_morphology1.37220550
38MP0003115_abnormal_respiratory_system1.36735108
39MP0000013_abnormal_adipose_tissue1.34693332
40MP0008875_abnormal_xenobiotic_pharmacok1.32939476
41MP0001299_abnormal_eye_distance/1.31330921
42MP0002234_abnormal_pharynx_morphology1.30729101
43MP0005508_abnormal_skeleton_morphology1.30383001
44MP0003385_abnormal_body_wall1.28714660
45MP0009250_abnormal_appendicular_skeleto1.26963093
46MP0003091_abnormal_cell_migration1.26732932
47MP0002295_abnormal_pulmonary_circulatio1.25387796
48MP0002282_abnormal_trachea_morphology1.24514727
49MP0006054_spinal_hemorrhage1.24218520
50MP0001348_abnormal_lacrimal_gland1.22828594
51MP0002896_abnormal_bone_mineralization1.22019613
52MP0000566_synostosis1.21967039
53MP0003935_abnormal_craniofacial_develop1.21291536
54MP0000428_abnormal_craniofacial_morphol1.17081470
55MP0002249_abnormal_larynx_morphology1.16716964
56MP0002009_preneoplasia1.16188226
57MP0005257_abnormal_intraocular_pressure1.15557702
58MP0005197_abnormal_uvea_morphology1.14174450
59MP0002168_other_aberrant_phenotype1.13204873
60MP0002108_abnormal_muscle_morphology1.13166044
61MP0004185_abnormal_adipocyte_glucose1.12863949
62MP0003942_abnormal_urinary_system1.10713125
63MP0000751_myopathy1.09726765
64MP0010678_abnormal_skin_adnexa1.08027874
65MP0002925_abnormal_cardiovascular_devel1.07812356
66MP0000432_abnormal_head_morphology1.06356111
67MP0000534_abnormal_ureter_morphology1.05602603
68MP0003755_abnormal_palate_morphology1.04354466
69MP0002877_abnormal_melanocyte_morpholog1.04078239
70MP0002938_white_spotting1.03035844
71MP0006138_congestive_heart_failure1.02933662
72MP0002128_abnormal_blood_circulation1.01262011
73MP0002932_abnormal_joint_morphology1.01073503
74MP0001849_ear_inflammation1.00687629
75MP0010630_abnormal_cardiac_muscle1.00531686
76MP0010329_abnormal_lipoprotein_level1.00358412
77MP0002233_abnormal_nose_morphology0.99771580
78MP0005164_abnormal_response_to0.96592884
79MP0010386_abnormal_urinary_bladder0.95611704
80MP0003448_altered_tumor_morphology0.94556595
81MP0000749_muscle_degeneration0.94344728
82MP0000613_abnormal_salivary_gland0.93636168
83MP0002138_abnormal_hepatobiliary_system0.93528478
84MP0002092_abnormal_eye_morphology0.92644620
85MP0005193_abnormal_anterior_eye0.92568979
86MP0009780_abnormal_chondrocyte_physiolo0.92531858
87MP0001915_intracranial_hemorrhage0.92496286
88MP0002160_abnormal_reproductive_system0.91156528
89MP0000003_abnormal_adipose_tissue0.90432579
90MP0000569_abnormal_digit_pigmentation0.90121463
91MP0000678_abnormal_parathyroid_gland0.89980292
92MP0002115_abnormal_skeleton_extremities0.89871610
93MP0005408_hypopigmentation0.89860975
94MP0000467_abnormal_esophagus_morphology0.89487840
95MP0002697_abnormal_eye_size0.88699011
96MP0001614_abnormal_blood_vessel0.88670426
97MP0003941_abnormal_skin_development0.88620138
98MP0005666_abnormal_adipose_tissue0.88609334
99MP0000163_abnormal_cartilage_morphology0.87288894
100MP0003567_abnormal_fetal_cardiomyocyte0.86246774
101MP0002088_abnormal_embryonic_growth/wei0.85822747
102MP0002086_abnormal_extraembryonic_tissu0.85608654
103MP0004197_abnormal_fetal_growth/weight/0.85433228
104MP0003283_abnormal_digestive_organ0.84706101
105MP0003984_embryonic_growth_retardation0.84660320
106MP0000383_abnormal_hair_follicle0.84028167
107MP0005220_abnormal_exocrine_pancreas0.83863831
108MP0003868_abnormal_feces_composition0.83728593
109MP0000049_abnormal_middle_ear0.83394634
110MP0000427_abnormal_hair_cycle0.83008936
111MP0005367_renal/urinary_system_phenotyp0.80606102
112MP0000516_abnormal_urinary_system0.80606102
113MP0002109_abnormal_limb_morphology0.80599957
114MP0005375_adipose_tissue_phenotype0.78909179
115MP0002332_abnormal_exercise_endurance0.78310098
116MP0003191_abnormal_cellular_cholesterol0.78261057
117MP0000266_abnormal_heart_morphology0.77233062
118MP0001243_abnormal_dermal_layer0.76680083
119MP0003119_abnormal_digestive_system0.76545372
120MP0003045_fibrosis0.75976572
121MP0005380_embryogenesis_phenotype0.75959084
122MP0001672_abnormal_embryogenesis/_devel0.75959084
123MP0001293_anophthalmia0.75878855
124MP0004134_abnormal_chest_morphology0.75369529
125MP0003828_pulmonary_edema0.75251613
126MP0002084_abnormal_developmental_patter0.74027993
127MP0001340_abnormal_eyelid_morphology0.72302490
128MP0003806_abnormal_nucleotide_metabolis0.72192632
129MP0004233_abnormal_muscle_weight0.72143925
130MP0005165_increased_susceptibility_to0.72005202
131MP0004084_abnormal_cardiac_muscle0.69236833
132MP0002113_abnormal_skeleton_development0.67244274
133MP0005390_skeleton_phenotype0.67115419
134MP0003315_abnormal_perineum_morphology0.66718625
135MP0002085_abnormal_embryonic_tissue0.64741509
136MP0000750_abnormal_muscle_regeneration0.63291165
137MP0000759_abnormal_skeletal_muscle0.62815310
138MP0001286_abnormal_eye_development0.61793403
139MP0000627_abnormal_mammary_gland0.61104799
140MP0005084_abnormal_gallbladder_morpholo0.59536713

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.83941781
2Shallow orbits (HP:0000586)4.23953833
3Deep venous thrombosis (HP:0002625)3.84112056
4Absent frontal sinuses (HP:0002688)3.75105262
5Premature rupture of membranes (HP:0001788)3.71714722
6Broad metatarsal (HP:0001783)3.55949070
7Aortic dissection (HP:0002647)3.42817648
8Aortic aneurysm (HP:0004942)3.32098646
9Ankle contracture (HP:0006466)3.22416986
10Mitral valve prolapse (HP:0001634)3.21341522
11Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.19489967
12Short 4th metacarpal (HP:0010044)3.19489967
13Cerebral aneurysm (HP:0004944)3.15019482
14Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)3.13015456
15Fragile skin (HP:0001030)2.84417827
16Abnormality of the frontal sinuses (HP:0002687)2.81651532
17Abnormality of the 4th metacarpal (HP:0010012)2.74760501
18Intrahepatic cholestasis (HP:0001406)2.63002665
19Hematochezia (HP:0002573)2.60650961
20Camptodactyly of toe (HP:0001836)2.56375845
21Cervical subluxation (HP:0003308)2.52999951
22Cardiovascular calcification (HP:0011915)2.50556079
23Aneurysm (HP:0002617)2.48527328
24Neonatal short-limb short stature (HP:0008921)2.44304323
25Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.43897984
26Peritonitis (HP:0002586)2.40492308
27Reduced subcutaneous adipose tissue (HP:0003758)2.39289759
28Entropion (HP:0000621)2.37560253
29Morphological abnormality of the middle ear (HP:0008609)2.37448034
30Atrophic scars (HP:0001075)2.37434408
31Dilatation of the ascending aorta (HP:0005111)2.37264151
32Esophageal varix (HP:0002040)2.36551253
33Subacute progressive viral hepatitis (HP:0006572)2.35974734
34Stenosis of the external auditory canal (HP:0000402)2.35559477
35Type 1 muscle fiber predominance (HP:0003803)2.31733088
36Thin bony cortex (HP:0002753)2.30929971
37Right ventricular cardiomyopathy (HP:0011663)2.28344300
38Arterial tortuosity (HP:0005116)2.26384650
39Rectal prolapse (HP:0002035)2.23778641
40Aortic regurgitation (HP:0001659)2.22396496
41Vascular tortuosity (HP:0004948)2.21861292
42Genu recurvatum (HP:0002816)2.19437655
43Aortic valve stenosis (HP:0001650)2.16250344
44Hypoalphalipoproteinemia (HP:0003233)2.12626140
45Wrist flexion contracture (HP:0001239)2.11917164
46Urethral obstruction (HP:0000796)2.11712637
47Abnormality of the proximal phalanges of the hand (HP:0009834)2.10040635
48Microglossia (HP:0000171)2.10009909
49Lymphangioma (HP:0100764)2.09528145
50Bell-shaped thorax (HP:0001591)2.08794117
51Myocardial infarction (HP:0001658)2.07853573
52Xanthomatosis (HP:0000991)2.07468012
53Asymmetry of the thorax (HP:0001555)2.05463733
54Hypoplastic ischia (HP:0003175)2.04627087
55Wide anterior fontanel (HP:0000260)2.04258980
56Abnormality of the ischium (HP:0003174)2.03038106
57Osteolytic defects of the phalanges of the hand (HP:0009771)1.98489168
58Osteolytic defects of the hand bones (HP:0009699)1.98489168
59Increased connective tissue (HP:0009025)1.98059347
60Adrenal hypoplasia (HP:0000835)1.97326507
61Disproportionate tall stature (HP:0001519)1.96399123
62Narrow palate (HP:0000189)1.94699328
63Volvulus (HP:0002580)1.93829515
64Spondylolisthesis (HP:0003302)1.93717425
65Bladder diverticulum (HP:0000015)1.93311899
66Midline defect of the nose (HP:0004122)1.91344277
67Hypoplastic labia majora (HP:0000059)1.91132105
68Deviation of the hallux (HP:0010051)1.89295004
69Tibial bowing (HP:0002982)1.88499701
70Glucose intolerance (HP:0000833)1.88404787
71Mesomelia (HP:0003027)1.88387480
72Scapular winging (HP:0003691)1.88378573
73Coronal craniosynostosis (HP:0004440)1.87926265
74Soft skin (HP:0000977)1.87689889
75Slender build (HP:0001533)1.87473549
76Natal tooth (HP:0000695)1.86024738
77Abnormality of monocarboxylic acid metabolism (HP:0010996)1.85929774
78Mitral stenosis (HP:0001718)1.85386290
79Pulmonic stenosis (HP:0001642)1.84180993
80Abnormality of dentin (HP:0010299)1.83463222
81Hallux valgus (HP:0001822)1.83147032
82Overgrowth (HP:0001548)1.82917855
83Abnormality of the parietal bone (HP:0002696)1.82812255
84Abnormality of the nasal septum (HP:0000419)1.82412246
85Blue sclerae (HP:0000592)1.81087250
86Abnormality of the common coagulation pathway (HP:0010990)1.80015353
87Mitral regurgitation (HP:0001653)1.79962309
88Abnormality of the distal phalanx of the thumb (HP:0009617)1.79866582
89Protruding ear (HP:0000411)1.79180272
90Abnormality of the umbilical cord (HP:0010881)1.78450942
91Bradycardia (HP:0001662)1.77603007
92Bowel diverticulosis (HP:0005222)1.77345464
93Vascular calcification (HP:0004934)1.76969651
94Short nail (HP:0001799)1.76945886
95Polycythemia (HP:0001901)1.76470440
96Kyphoscoliosis (HP:0002751)1.76095587
97Hyperglycemia (HP:0003074)1.75880135
98Follicular hyperkeratosis (HP:0007502)1.75674086
99Mildly elevated creatine phosphokinase (HP:0008180)1.75312471
100Broad face (HP:0000283)1.74942165
101Exostoses (HP:0100777)1.74688077
102Wormian bones (HP:0002645)1.73439884
103Spinal rigidity (HP:0003306)1.72032251
104Buphthalmos (HP:0000557)1.71733478
105Hepatocellular carcinoma (HP:0001402)1.71668831
106Flexion contracture of toe (HP:0005830)1.70999361
107Joint contractures involving the joints of the feet (HP:0100492)1.70999361
108Fibular aplasia (HP:0002990)1.70825658
109Congenital, generalized hypertrichosis (HP:0004540)1.70504063
110Ulnar bowing (HP:0003031)1.70124921
111Delayed gross motor development (HP:0002194)1.69916890
112Radial bowing (HP:0002986)1.69860719
113Infantile muscular hypotonia (HP:0008947)1.68780767
114Complement deficiency (HP:0004431)1.68273518
115Hypolipoproteinemia (HP:0010981)1.67305084
116Abnormality of the distal phalanges of the toes (HP:0010182)1.67011304
117Increased number of teeth (HP:0011069)1.66644430
118Knee flexion contracture (HP:0006380)1.66475244
119Joint laxity (HP:0001388)1.66344393
120Abnormal umbilical cord blood vessels (HP:0011403)1.66196909
121Single umbilical artery (HP:0001195)1.66196909
122Abnormality of the fetal cardiovascular system (HP:0010948)1.66196909
123Hyperextensible skin (HP:0000974)1.66177099
124Abnormality of the labia majora (HP:0012881)1.65536163
125Epidermoid cyst (HP:0200040)1.65252723
126Vertebral compression fractures (HP:0002953)1.64947379
127Papillary thyroid carcinoma (HP:0002895)1.64935614
128Hydroureter (HP:0000072)1.64857068
129Chorioretinal atrophy (HP:0000533)1.64223271
130Hypoventilation (HP:0002791)1.63318639
131Coxa valga (HP:0002673)1.63305159
132Tarsal synostosis (HP:0008368)1.63083888
133Abnormal delivery (HP:0001787)1.62247909
134Bowed forearm bones (HP:0003956)1.61680684
135Bowing of the arm (HP:0006488)1.61680684
136Increased corneal curvature (HP:0100692)1.61361113
137Keratoconus (HP:0000563)1.61361113
138Abnormality of the peritoneum (HP:0002585)1.61124494
139Abnormality of the intrinsic pathway (HP:0010989)1.61091649
140Achilles tendon contracture (HP:0001771)1.61066421
141Turricephaly (HP:0000262)1.59457428
142Venous abnormality (HP:0002624)1.57470942
143Enlarged penis (HP:0000040)1.55569822
144Spinal cord lesions (HP:0100561)1.55024957
145Syringomyelia (HP:0003396)1.55024957
146Cortical dysplasia (HP:0002539)1.54661879
147Hepatoblastoma (HP:0002884)1.54644054
148Long toe (HP:0010511)1.54626949
149Hypoglycemic coma (HP:0001325)1.54597487
150Persistence of primary teeth (HP:0006335)1.54461760
151Elbow flexion contracture (HP:0002987)1.54126577
152Abnormality of the acetabulum (HP:0003170)1.54050372

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS15.19231674
2MYLK2.77043456
3LIMK12.64363445
4TRIB32.50619464
5STK32.31627415
6STK38L2.29353729
7NEK12.22227902
8SIK12.21047278
9FRK2.17588390
10LATS22.15921509
11TTN2.07589048
12PDGFRA2.04749633
13DDR21.95942062
14PKN21.94371025
15FGFR21.90971671
16DMPK1.90495986
17PTK61.87487003
18TGFBR21.81999438
19EPHA31.81937097
20NUAK11.75136164
21EPHB21.75016011
22SCYL21.70669952
23CAMK1D1.70614539
24CDK121.69081895
25TIE11.64464261
26RIPK11.63077619
27CAMK1G1.59396521
28FGFR41.58138523
29NTRK11.55437582
30BUB11.53145399
31MOS1.50987171
32TESK11.50661344
33FLT31.50489939
34MAP3K121.47269356
35NEK91.44479884
36CDK61.44051938
37IRAK31.41753990
38MST41.39408547
39LMTK21.32099533
40FER1.26945593
41PRKD31.26372158
42FGFR31.25939476
43MAP3K101.23911701
44MTOR1.21080463
45EPHB11.20048710
46PDGFRB1.19177201
47PTK21.18523896
48ABL21.18475086
49PIK3CA1.17622456
50ERBB41.17400149
51TGFBR11.16394564
52MELK1.14773570
53STK101.14171516
54AKT31.13025851
55BRSK21.12262780
56CDK91.10454387
57RPS6KA41.09792306
58PLK21.03160709
59PAK21.03010221
60EPHA21.02565176
61PAK31.01368776
62FGFR11.00822739
63GRK71.00813979
64EEF2K1.00124266
65ROCK20.98304446
66LRRK20.95854378
67KDR0.93630490
68PBK0.92012878
69ADRBK10.91888770
70PDK40.90779130
71PDK30.90779130
72CDK80.89301131
73CSNK1A1L0.88021747
74CSNK1G10.87465780
75MET0.86050119
76NLK0.85065389
77MAP3K20.82183585
78ERBB20.81651314
79PRKAA20.81127356
80STK380.79707170
81TYRO30.79575243
82BCR0.78434158
83MAP3K60.77480357
84ROCK10.77286076
85RET0.75983239
86PLK30.72369181
87TRIM280.71737540
88MAP3K30.71256160
89DYRK1B0.71225753
90TAOK30.70637192
91PRKG20.70604537
92ERN10.68397105
93INSRR0.67904540
94MAP3K70.67477454
95TRPM70.67300779
96PDK20.66742556
97ICK0.65533003
98PRKD20.62478869
99PRKD10.61837689
100JAK10.61618574
101NEK20.61147665
102EIF2AK30.60854994
103PRKCE0.58641061
104ERBB30.58374383
105PNCK0.57427547
106NME20.56806757
107GSK3A0.56748705
108BMX0.55993056
109PRKCI0.54654839
110PIM20.53124690
111MAP3K80.51065822
112WNK40.50120893
113CLK10.49978022
114MST1R0.49528648
115WNK10.49097601
116PLK10.48764090
117PTK2B0.48124762
118EIF2AK20.47971036
119GRK10.47762105
120PRKAA10.47619388
121KSR10.47049666
122ARAF0.46919860
123PRKCH0.45602637
124ILK0.43739237
125ABL10.43284027
126IGF1R0.43220651
127CHUK0.43172829
128PAK40.42025162
129STK390.41988102
130CSNK1G20.40780647
131PAK60.40449176
132TSSK60.40277770
133CSNK1D0.39340206
134SGK30.39007163
135CSK0.38994385
136AURKB0.38041806
137TYK20.37892748
138CHEK20.37394825
139EIF2AK10.37000798
140SRPK10.36938409
141TTK0.36274670
142INSR0.35803298
143MARK20.35561148
144TAF10.35454948
145TAOK10.35384432
146MAPK10.35091415
147EGFR0.34968910
148MKNK20.34838579
149MAP3K140.28662628
150WEE10.28050055
151MAP2K70.26189789

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.30344996
2Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.96341929
3Primary bile acid biosynthesis_Homo sapiens_hsa001202.53386424
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.26081411
5Adherens junction_Homo sapiens_hsa045202.11300799
6ECM-receptor interaction_Homo sapiens_hsa045122.11277453
7Complement and coagulation cascades_Homo sapiens_hsa046101.95352793
8Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.82294208
9Lysine degradation_Homo sapiens_hsa003101.80202119
10Focal adhesion_Homo sapiens_hsa045101.79021449
11p53 signaling pathway_Homo sapiens_hsa041151.76960077
12Fatty acid degradation_Homo sapiens_hsa000711.74963418
13* TGF-beta signaling pathway_Homo sapiens_hsa043501.70745016
14Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.67677834
15Arginine biosynthesis_Homo sapiens_hsa002201.66918717
16Small cell lung cancer_Homo sapiens_hsa052221.56553813
17PPAR signaling pathway_Homo sapiens_hsa033201.55108596
18Tryptophan metabolism_Homo sapiens_hsa003801.53513514
19Proteoglycans in cancer_Homo sapiens_hsa052051.50434379
20Axon guidance_Homo sapiens_hsa043601.47014541
21MicroRNAs in cancer_Homo sapiens_hsa052061.46299826
22Hippo signaling pathway_Homo sapiens_hsa043901.38977874
23Shigellosis_Homo sapiens_hsa051311.36226530
24Caffeine metabolism_Homo sapiens_hsa002321.34788105
25Selenocompound metabolism_Homo sapiens_hsa004501.32685402
26Basal cell carcinoma_Homo sapiens_hsa052171.29463760
27Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.26832732
28Prostate cancer_Homo sapiens_hsa052151.25825539
29Insulin resistance_Homo sapiens_hsa049311.24703479
30Fatty acid metabolism_Homo sapiens_hsa012121.24599478
31Pentose and glucuronate interconversions_Homo sapiens_hsa000401.22420137
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.21507161
33Basal transcription factors_Homo sapiens_hsa030221.17441772
34Gap junction_Homo sapiens_hsa045401.14568883
35Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.14261451
36AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.11993680
37Chronic myeloid leukemia_Homo sapiens_hsa052201.11897743
38Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.11804737
39Amoebiasis_Homo sapiens_hsa051461.11179509
40Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.10974948
41Bile secretion_Homo sapiens_hsa049761.07740264
42Dorso-ventral axis formation_Homo sapiens_hsa043201.07668171
43Butanoate metabolism_Homo sapiens_hsa006501.07200670
44Steroid hormone biosynthesis_Homo sapiens_hsa001401.07053563
45Chemical carcinogenesis_Homo sapiens_hsa052041.05951381
46Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.05291206
47Propanoate metabolism_Homo sapiens_hsa006401.05208637
48Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.01284173
49Glycosaminoglycan degradation_Homo sapiens_hsa005311.00748152
50Protein digestion and absorption_Homo sapiens_hsa049740.99273365
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.96945695
52Ras signaling pathway_Homo sapiens_hsa040140.96875139
53Pancreatic cancer_Homo sapiens_hsa052120.95757228
54Melanogenesis_Homo sapiens_hsa049160.93909820
55Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.92457142
56Leukocyte transendothelial migration_Homo sapiens_hsa046700.91826848
57Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.91758745
58Renal cell carcinoma_Homo sapiens_hsa052110.91371571
59Bladder cancer_Homo sapiens_hsa052190.91041842
60Tight junction_Homo sapiens_hsa045300.88915319
61Retinol metabolism_Homo sapiens_hsa008300.88846226
62Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.86827777
63* Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.86596674
64Cell cycle_Homo sapiens_hsa041100.85912176
65Hedgehog signaling pathway_Homo sapiens_hsa043400.85039735
66Nucleotide excision repair_Homo sapiens_hsa034200.83459387
67AMPK signaling pathway_Homo sapiens_hsa041520.82454916
68Fatty acid biosynthesis_Homo sapiens_hsa000610.82249006
69Salmonella infection_Homo sapiens_hsa051320.81185246
70mTOR signaling pathway_Homo sapiens_hsa041500.80901617
71Starch and sucrose metabolism_Homo sapiens_hsa005000.80418871
72* Endocytosis_Homo sapiens_hsa041440.80113436
73PI3K-Akt signaling pathway_Homo sapiens_hsa041510.79057496
74Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.78801777
75Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.78568396
76Pathways in cancer_Homo sapiens_hsa052000.77861195
77Dilated cardiomyopathy_Homo sapiens_hsa054140.77755059
78Sulfur metabolism_Homo sapiens_hsa009200.77053477
79Viral myocarditis_Homo sapiens_hsa054160.76949201
80Sphingolipid metabolism_Homo sapiens_hsa006000.76757608
81ErbB signaling pathway_Homo sapiens_hsa040120.76531802
82Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.76463621
83Notch signaling pathway_Homo sapiens_hsa043300.76061016
84Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.75862969
85Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75790996
86TNF signaling pathway_Homo sapiens_hsa046680.73271327
87Longevity regulating pathway - mammal_Homo sapiens_hsa042110.73259043
88Endometrial cancer_Homo sapiens_hsa052130.73036954
89Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.73026190
90Adipocytokine signaling pathway_Homo sapiens_hsa049200.72607370
91Staphylococcus aureus infection_Homo sapiens_hsa051500.71407852
92Ovarian steroidogenesis_Homo sapiens_hsa049130.70974914
93Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.69262781
94Pancreatic secretion_Homo sapiens_hsa049720.68965958
95N-Glycan biosynthesis_Homo sapiens_hsa005100.68675757
96Toxoplasmosis_Homo sapiens_hsa051450.68637928
97Peroxisome_Homo sapiens_hsa041460.68441148
98Regulation of actin cytoskeleton_Homo sapiens_hsa048100.68099738
99Thyroid hormone signaling pathway_Homo sapiens_hsa049190.67276916
100Neurotrophin signaling pathway_Homo sapiens_hsa047220.67161647
101FoxO signaling pathway_Homo sapiens_hsa040680.66097606
102Fat digestion and absorption_Homo sapiens_hsa049750.65680542
103Rap1 signaling pathway_Homo sapiens_hsa040150.63625497
104Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63205133
105Circadian rhythm_Homo sapiens_hsa047100.62236351
106ABC transporters_Homo sapiens_hsa020100.61661824
107Colorectal cancer_Homo sapiens_hsa052100.60309440
108Melanoma_Homo sapiens_hsa052180.59953581
109Glucagon signaling pathway_Homo sapiens_hsa049220.59820304
110Non-homologous end-joining_Homo sapiens_hsa034500.59608982
111Wnt signaling pathway_Homo sapiens_hsa043100.59095494
112MAPK signaling pathway_Homo sapiens_hsa040100.58325185
113Drug metabolism - other enzymes_Homo sapiens_hsa009830.57088303
114Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.57007450
115Apoptosis_Homo sapiens_hsa042100.56893395
116Platelet activation_Homo sapiens_hsa046110.56528484
117Phospholipase D signaling pathway_Homo sapiens_hsa040720.55515250
118Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.55409008
119Estrogen signaling pathway_Homo sapiens_hsa049150.55258382
120beta-Alanine metabolism_Homo sapiens_hsa004100.54323000
121Sphingolipid signaling pathway_Homo sapiens_hsa040710.54315270
122Maturity onset diabetes of the young_Homo sapiens_hsa049500.53960351
123Tyrosine metabolism_Homo sapiens_hsa003500.53757874
124Thyroid hormone synthesis_Homo sapiens_hsa049180.52581778
125Histidine metabolism_Homo sapiens_hsa003400.51641304
126Hepatitis B_Homo sapiens_hsa051610.51337161
127Protein export_Homo sapiens_hsa030600.50239093
128Vascular smooth muscle contraction_Homo sapiens_hsa042700.49934431
129Viral carcinogenesis_Homo sapiens_hsa052030.49804844
130HTLV-I infection_Homo sapiens_hsa051660.47809058
131Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.47676255
132Insulin signaling pathway_Homo sapiens_hsa049100.47517866
133Malaria_Homo sapiens_hsa051440.46592829
134Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.45706874
135Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45384546
136Glioma_Homo sapiens_hsa052140.44771969
137Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44525288
138Thyroid cancer_Homo sapiens_hsa052160.44489299
139Phenylalanine metabolism_Homo sapiens_hsa003600.44425141
140Central carbon metabolism in cancer_Homo sapiens_hsa052300.44396316
141Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.43717668
142Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.43703989
143Vibrio cholerae infection_Homo sapiens_hsa051100.43470587
144Cocaine addiction_Homo sapiens_hsa050300.40655695
145cGMP-PKG signaling pathway_Homo sapiens_hsa040220.38869877
146Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.38342749
147VEGF signaling pathway_Homo sapiens_hsa043700.37473230
148Hepatitis C_Homo sapiens_hsa051600.36130414
149Glutathione metabolism_Homo sapiens_hsa004800.35334259
150Pyrimidine metabolism_Homo sapiens_hsa002400.33747941
151Inositol phosphate metabolism_Homo sapiens_hsa005620.31961473
152Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.31205209
153Long-term depression_Homo sapiens_hsa047300.31064895
154RNA transport_Homo sapiens_hsa030130.30977597

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