SMYD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: SET domain-containing proteins, such as SMYD2, catalyze lysine methylation (Brown et al., 2006 [PubMed 16805913]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)5.91161750
2muscle filament sliding (GO:0030049)5.59223063
3actin-myosin filament sliding (GO:0033275)5.59223063
4tricarboxylic acid cycle (GO:0006099)5.29867031
5positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.16882558
6mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.14415824
7oxidative phosphorylation (GO:0006119)5.09602001
8ribosomal small subunit assembly (GO:0000028)4.83825049
9cardiac myofibril assembly (GO:0055003)4.82683044
10desmosome organization (GO:0002934)4.76323883
11ATP synthesis coupled proton transport (GO:0015986)4.71199859
12energy coupled proton transport, down electrochemical gradient (GO:0015985)4.71199859
13bundle of His cell to Purkinje myocyte communication (GO:0086069)4.60120322
14regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.55947120
15viral transcription (GO:0019083)4.47861323
16axonemal dynein complex assembly (GO:0070286)4.47732958
17myofibril assembly (GO:0030239)4.37363494
18cardiac muscle contraction (GO:0060048)4.37179624
19translational termination (GO:0006415)4.35919839
20actin-mediated cell contraction (GO:0070252)4.28636657
21plasma membrane repair (GO:0001778)4.23435624
22response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.21514930
23regulation of skeletal muscle contraction (GO:0014819)4.20863676
24translational elongation (GO:0006414)4.20150933
25regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.15514895
26galactose catabolic process (GO:0019388)4.14973779
27IMP metabolic process (GO:0046040)4.14598767
28regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.07254763
29IMP biosynthetic process (GO:0006188)4.02992837
30oxaloacetate metabolic process (GO:0006107)3.97572704
31DNA deamination (GO:0045006)3.96503642
32SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.95225054
33regulation of coenzyme metabolic process (GO:0051196)3.88437346
34regulation of cofactor metabolic process (GO:0051193)3.88437346
35motile cilium assembly (GO:0044458)3.85596565
36NADH metabolic process (GO:0006734)3.85115404
37regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.84179727
38protein targeting to ER (GO:0045047)3.83439960
39negative regulation of potassium ion transmembrane transport (GO:1901380)3.80713054
40cotranslational protein targeting to membrane (GO:0006613)3.79312440
41cardiac muscle hypertrophy (GO:0003300)3.78933786
42regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.78171921
43negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.75809372
44ventricular cardiac muscle cell action potential (GO:0086005)3.74741696
45establishment of protein localization to endoplasmic reticulum (GO:0072599)3.74281952
46maturation of SSU-rRNA (GO:0030490)3.73934636
47cardiac muscle cell development (GO:0055013)3.71876691
48regulation of cardioblast differentiation (GO:0051890)3.69824376
49sarcoplasmic reticulum calcium ion transport (GO:0070296)3.68026578
50cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.66824281
51cell communication involved in cardiac conduction (GO:0086065)3.64527530
52protein localization to endoplasmic reticulum (GO:0070972)3.64096563
53purine nucleotide salvage (GO:0032261)3.60307020
54respiratory electron transport chain (GO:0022904)3.58833448
55striated muscle contraction (GO:0006941)3.57314896
56ribosomal small subunit biogenesis (GO:0042274)3.57227718
57regulation of acyl-CoA biosynthetic process (GO:0050812)3.56833947
58skeletal muscle contraction (GO:0003009)3.56143236
59translational initiation (GO:0006413)3.54586056
60striated muscle hypertrophy (GO:0014897)3.54344690
61regulation of the force of heart contraction (GO:0002026)3.53928246
62actomyosin structure organization (GO:0031032)3.50955503
63regulation of relaxation of muscle (GO:1901077)3.50371917
64electron transport chain (GO:0022900)3.50173653
65regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.49412552
66ubiquinone biosynthetic process (GO:0006744)3.49248220
67quinone biosynthetic process (GO:1901663)3.49248220
68cellular protein complex disassembly (GO:0043624)3.41720483
69inner mitochondrial membrane organization (GO:0007007)3.39718890
70nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.38154052
71tricarboxylic acid metabolic process (GO:0072350)3.37742915
72carnitine shuttle (GO:0006853)3.37470544
73cardiac cell development (GO:0055006)3.36850437
74formation of translation preinitiation complex (GO:0001731)3.35386455
75viral life cycle (GO:0019058)3.34401698
76COPI coating of Golgi vesicle (GO:0048205)3.32670903
77Golgi transport vesicle coating (GO:0048200)3.32670903
78negative regulation of necroptotic process (GO:0060546)3.19467309
79mitochondrial fusion (GO:0008053)3.18840095
80regulation of cell communication by electrical coupling (GO:0010649)3.17959648
81regulation of actin filament-based movement (GO:1903115)3.17757419
82protein maturation by protein folding (GO:0022417)3.17431746
83negative regulation of cell size (GO:0045792)3.15960735
84succinate metabolic process (GO:0006105)3.15048212
85cardiac muscle tissue morphogenesis (GO:0055008)3.13189294
86purine nucleoside monophosphate biosynthetic process (GO:0009127)3.12299680
87purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.12299680
88response to muscle activity (GO:0014850)3.11098245
89cell communication by electrical coupling (GO:0010644)3.10741254
90purine-containing compound salvage (GO:0043101)3.04728976
91regulation of sarcomere organization (GO:0060297)3.03588440
92muscle hypertrophy (GO:0014896)3.03317264
93erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.01611869
94L-phenylalanine metabolic process (GO:0006558)3.01611869
95protein complex disassembly (GO:0043241)3.01139688
96ATP biosynthetic process (GO:0006754)3.01079776
97protein hydroxylation (GO:0018126)3.00735777
98mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.00132279
99positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.00111012
100DNA unwinding involved in DNA replication (GO:0006268)2.99028189
101ubiquinone metabolic process (GO:0006743)2.98367915
102actin filament-based movement (GO:0030048)2.96486062
103regulation of cardiac muscle cell contraction (GO:0086004)2.95947380
104glucan catabolic process (GO:0009251)2.95397689
105heart process (GO:0003015)2.94988289
106heart contraction (GO:0060047)2.94988289
1072-oxoglutarate metabolic process (GO:0006103)2.94534656
108cilium or flagellum-dependent cell motility (GO:0001539)2.94204100
109heart trabecula formation (GO:0060347)2.94201650
110carnitine transmembrane transport (GO:1902603)2.94187264
111protein carboxylation (GO:0018214)2.93886100
112peptidyl-glutamic acid carboxylation (GO:0017187)2.93886100
113regulation of protein activation cascade (GO:2000257)2.91775451
114detection of calcium ion (GO:0005513)2.91667618
115negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.91121673
116regulation of complement activation (GO:0030449)2.90572711
117regulation of ATPase activity (GO:0043462)2.90522435
118regulation of ATP catabolic process (GO:1903289)2.90522435
119ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.90073750
120macromolecular complex disassembly (GO:0032984)2.90011097
121glycogen catabolic process (GO:0005980)2.88394817
122deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.87565447
123retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.87340888
124folic acid-containing compound biosynthetic process (GO:0009396)2.87337551
125creatine metabolic process (GO:0006600)2.86463134
126translation (GO:0006412)2.85956708
127regulation of mitochondrial translation (GO:0070129)2.85236389
128muscle tissue morphogenesis (GO:0060415)2.83822056
129regulation of striated muscle contraction (GO:0006942)2.83367702
130regulation of oxidative phosphorylation (GO:0002082)2.81477850
131muscle contraction (GO:0006936)2.79873909
1324-hydroxyproline metabolic process (GO:0019471)2.79047009
133negative regulation of fibrinolysis (GO:0051918)2.77780004
134cellular polysaccharide catabolic process (GO:0044247)2.77300821
135left/right pattern formation (GO:0060972)2.76385739
136amino-acid betaine transport (GO:0015838)2.75315052
137carnitine transport (GO:0015879)2.75315052
138hypotonic response (GO:0006971)2.73676904
139embryonic heart tube development (GO:0035050)2.73208285
140vitamin transmembrane transport (GO:0035461)2.72017707
141regulation of heart rate (GO:0002027)2.69667586
142negative regulation of catenin import into nucleus (GO:0035414)2.67311830
143regulation of calcium ion transmembrane transporter activity (GO:1901019)2.66910268
144regulation of calcium ion transmembrane transport (GO:1903169)2.66910268
145calcium-mediated signaling using intracellular calcium source (GO:0035584)2.62566314
146negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.61103297
147negative regulation of calcium ion transmembrane transport (GO:1903170)2.61103297
148intestinal cholesterol absorption (GO:0030299)2.61082164
149regulation of fibrinolysis (GO:0051917)2.60127135
150cardiac muscle adaptation (GO:0014887)2.59714188
151cardiac muscle hypertrophy in response to stress (GO:0014898)2.59714188
152muscle hypertrophy in response to stress (GO:0003299)2.59714188
153epithelial cell-cell adhesion (GO:0090136)2.58698110
154nucleoside diphosphate biosynthetic process (GO:0009133)2.58691236
155negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.57033449
156hemidesmosome assembly (GO:0031581)2.54632588
157cell-substrate junction assembly (GO:0007044)2.54529548
158neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.53996198

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse5.34001133
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.51024057
3TRIM28_21343339_ChIP-Seq_HEK293_Human4.35394812
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.06733606
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.85169163
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.68663433
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.51824514
8E2F7_22180533_ChIP-Seq_HELA_Human3.18201173
9ZNF263_19887448_ChIP-Seq_K562_Human2.98188331
10ESR1_20079471_ChIP-ChIP_T-47D_Human2.89739978
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.85404822
12ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.74256749
13CLOCK_20551151_ChIP-Seq_293T_Human2.68603818
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.67447338
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.61262978
16ESR2_21235772_ChIP-Seq_MCF-7_Human2.58891130
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.58764251
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.50734370
19EP300_21415370_ChIP-Seq_HL-1_Mouse2.41463442
20RXR_22158963_ChIP-Seq_LIVER_Mouse2.41290692
21* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.38471938
22* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.29635720
23XRN2_22483619_ChIP-Seq_HELA_Human2.28898132
24TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.28703480
25* ZFX_18555785_ChIP-Seq_MESCs_Mouse2.28078971
26THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.26423702
27* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.25510177
28GABP_17652178_ChIP-ChIP_JURKAT_Human2.18717159
29SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.18693403
30TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.17197662
31CREB1_15753290_ChIP-ChIP_HEK293T_Human2.15944786
32THAP11_20581084_ChIP-Seq_MESCs_Mouse2.12898405
33* RACK7_27058665_Chip-Seq_MCF-7_Human2.12629427
34MYC_22102868_ChIP-Seq_BL_Human2.11385336
35EST1_17652178_ChIP-ChIP_JURKAT_Human2.10947149
36KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human2.05012269
37DCP1A_22483619_ChIP-Seq_HELA_Human2.00369637
38FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.99124286
39E2F1_18555785_ChIP-Seq_MESCs_Mouse1.94055186
40TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.85889600
41PPARA_22158963_ChIP-Seq_LIVER_Mouse1.85648446
42NELFA_20434984_ChIP-Seq_ESCs_Mouse1.82880745
43NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.82724247
44PPAR_26484153_Chip-Seq_NCI-H1993_Human1.82595456
45GABP_19822575_ChIP-Seq_HepG2_Human1.82261448
46KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.81663487
47NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.80284466
48HIF1A_21447827_ChIP-Seq_MCF-7_Human1.77307638
49* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.77031752
50RARG_19884340_ChIP-ChIP_MEFs_Mouse1.74990209
51CIITA_25753668_ChIP-Seq_RAJI_Human1.72080242
52SRF_21415370_ChIP-Seq_HL-1_Mouse1.71915053
53BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.62891943
54TTF2_22483619_ChIP-Seq_HELA_Human1.61993709
55LXR_22158963_ChIP-Seq_LIVER_Mouse1.61056008
56PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60893457
57FOXA2_19822575_ChIP-Seq_HepG2_Human1.58511854
58TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.58117718
59STAT3_1855785_ChIP-Seq_MESCs_Mouse1.57759945
60VDR_23849224_ChIP-Seq_CD4+_Human1.55682785
61RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.55448328
62CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.54647923
63SOX9_24532713_ChIP-Seq_HFSC_Mouse1.52584210
64* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.51860512
65* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.51860512
66SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.51416639
67SOX2_27498859_Chip-Seq_STOMACH_Mouse1.51393620
68VDR_21846776_ChIP-Seq_THP-1_Human1.51097410
69DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.50774438
70ELF1_17652178_ChIP-ChIP_JURKAT_Human1.49500225
71SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.47994050
72MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.46527794
73ESR1_15608294_ChIP-ChIP_MCF-7_Human1.45754562
74CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.44537139
75* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.42081789
76TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.41549295
77FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.40743656
78SALL4_18804426_ChIP-ChIP_XEN_Mouse1.40665177
79FOXP3_21729870_ChIP-Seq_TREG_Human1.39350498
80GATA4_21415370_ChIP-Seq_HL-1_Mouse1.38561391
81LXR_22292898_ChIP-Seq_THP-1_Human1.38155390
82TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.37529189
83DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.37518137
84* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.36813861
85PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.36486259
86* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.36304018
87ELK3_25401928_ChIP-Seq_HUVEC_Human1.35781043
88CDX2_19796622_ChIP-Seq_MESCs_Mouse1.33441492
89ERG_20887958_ChIP-Seq_HPC-7_Mouse1.32435388
90RUNX1_27514584_Chip-Seq_MCF-7_Human1.32172412
91* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.30123192
92KLF4_18555785_ChIP-Seq_MESCs_Mouse1.29414343
93RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.29378270
94TBX5_21415370_ChIP-Seq_HL-1_Mouse1.28721687
95HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.28528468
96YY1_21170310_ChIP-Seq_MESCs_Mouse1.28150117
97SOX2_20726797_ChIP-Seq_SW620_Human1.28105885
98* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.27594827
99ATF3_27146783_Chip-Seq_COLON_Human1.27456482
100MYCN_18555785_ChIP-Seq_MESCs_Mouse1.27069882
101TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.26476727
102CTCF_18555785_ChIP-Seq_MESCs_Mouse1.26156317
103GATA1_22025678_ChIP-Seq_K562_Human1.25675754
104CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.23554659
105YY1_22570637_ChIP-Seq_MALME-3M_Human1.22662010
106FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.21774921
107HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.21451238
108SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.20766525
109* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.20747504
110SRY_22984422_ChIP-ChIP_TESTIS_Rat1.20535835
111GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.20447965
112FOXP1_21924763_ChIP-Seq_HESCs_Human1.19667688
113CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.19660686
114CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.19585455
115ESR1_21235772_ChIP-Seq_MCF-7_Human1.19121313
116GATA2_21666600_ChIP-Seq_HMVEC_Human1.16149193
117FOXO3_23340844_ChIP-Seq_DLD1_Human1.15426173
118ELF1_20517297_ChIP-Seq_JURKAT_Human1.15294191
119POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.15282682
120YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.15015743
121CDX2_20551321_ChIP-Seq_CACO-2_Human1.14535986
122SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.14483272
123PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.14210354
124TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.13520156
125* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.13378716
126UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.12676021
127ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.12634993
128RBPJ_22232070_ChIP-Seq_NCS_Mouse1.12079446
129NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.11655797
130RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11188385
131GATA3_24758297_ChIP-Seq_MCF-7_Human1.10720620
132* CTCF_21964334_Chip-Seq_Bcells_Human1.09991691
133ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.09790781
134GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.09546925
135BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.09397553
136TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.08887560
137SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.08796926
138NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.08485435
139FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.07731874
140GATA6_25053715_ChIP-Seq_YYC3_Human1.06760189
141BCL6_27268052_Chip-Seq_Bcells_Human1.06032896
142P68_20966046_ChIP-Seq_HELA_Human1.05380032
143ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05289035
144* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.04935626
145SMC4_20622854_ChIP-Seq_HELA_Human1.04077533
146CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.03611541
147WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.03389806
148EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.02087238
149PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.01844544
150SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01598950
151* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.01104443
152TFEB_21752829_ChIP-Seq_HELA_Human1.00844301
153CTCF_21964334_ChIP-Seq_BJAB-B_Human1.00332714
154E2F1_21310950_ChIP-Seq_MCF-7_Human1.00143546
155ZNF217_24962896_ChIP-Seq_MCF-7_Human0.99591190
156KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.99499538
157TET1_21451524_ChIP-Seq_MESCs_Mouse0.99127672
158AR_21909140_ChIP-Seq_LNCAP_Human0.98971656
159* KDM2B_26808549_Chip-Seq_K562_Human0.98517162
160NOTCH1_21737748_ChIP-Seq_TLL_Human0.98303105
161PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.97671739
162* TBX20_22328084_ChIP-Seq_HEART_Mouse0.97670574
163* TBX20_22080862_ChIP-Seq_HEART_Mouse0.97670574
164NFIB_24661679_ChIP-Seq_LUNG_Mouse0.97130961
165* UBF1/2_26484160_Chip-Seq_HMECs_Human0.91625789
166ERG_21242973_ChIP-ChIP_JURKAT_Human0.90243153
167CREB1_26743006_Chip-Seq_LNCaP_Human0.89952193
168* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.89165502
169* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.87543931
170TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.87145156
171TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.85861212
172CTNNB1_20460455_ChIP-Seq_HCT116_Human0.85103377
173TCF7_22412390_ChIP-Seq_EML_Mouse0.83568437

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000751_myopathy4.94100468
2MP0002837_dystrophic_cardiac_calcinosis4.91916311
3MP0004084_abnormal_cardiac_muscle4.81989357
4MP0000749_muscle_degeneration4.09704626
5MP0003646_muscle_fatigue3.84788662
6MP0004215_abnormal_myocardial_fiber3.76786639
7MP0004036_abnormal_muscle_relaxation3.69876584
8MP0004145_abnormal_muscle_electrophysio3.68192964
9MP0005330_cardiomyopathy3.30110456
10MP0009780_abnormal_chondrocyte_physiolo3.08838581
11MP0000747_muscle_weakness3.00511060
12MP0000750_abnormal_muscle_regeneration2.92971738
13MP0002269_muscular_atrophy2.90773195
14MP0004087_abnormal_muscle_fiber2.89923977
15MP0002106_abnormal_muscle_physiology2.71323851
16MP0006036_abnormal_mitochondrial_physio2.55420476
17MP0004233_abnormal_muscle_weight2.43964029
18MP0008775_abnormal_heart_ventricle2.40457913
19MP0000759_abnormal_skeletal_muscle2.33651511
20MP0005620_abnormal_muscle_contractility2.30452885
21MP0005451_abnormal_body_composition2.25632390
22MP0002972_abnormal_cardiac_muscle2.21512098
23MP0005369_muscle_phenotype2.19127701
24MP0003137_abnormal_impulse_conducting2.16736388
25MP0010630_abnormal_cardiac_muscle2.12845765
26MP0001661_extended_life_span2.07447123
27MP0003221_abnormal_cardiomyocyte_apopto2.03337520
28MP0004130_abnormal_muscle_cell2.02191313
29MP0003950_abnormal_plasma_membrane1.96396737
30MP0005385_cardiovascular_system_phenoty1.93060465
31MP0001544_abnormal_cardiovascular_syste1.93060465
32MP0004272_abnormal_basement_membrane1.90212523
33MP0002234_abnormal_pharynx_morphology1.86677644
34MP0010234_abnormal_vibrissa_follicle1.83946653
35MP0006035_abnormal_mitochondrial_morpho1.78414446
36MP0008875_abnormal_xenobiotic_pharmacok1.69124251
37MP0003705_abnormal_hypodermis_morpholog1.60742776
38MP0006138_congestive_heart_failure1.58547626
39MP0006054_spinal_hemorrhage1.57007176
40MP0003567_abnormal_fetal_cardiomyocyte1.54074107
41MP0004484_altered_response_of1.53717763
42MP0003123_paternal_imprinting1.53106078
43MP0003806_abnormal_nucleotide_metabolis1.52479572
44MP0005409_darkened_coat_color1.50205587
45MP0002877_abnormal_melanocyte_morpholog1.45850318
46MP0005408_hypopigmentation1.41753937
47MP0004085_abnormal_heartbeat1.36101346
48MP0002139_abnormal_hepatobiliary_system1.33980294
49MP0002909_abnormal_adrenal_gland1.32288288
50MP0003279_aneurysm1.32109967
51MP0001879_abnormal_lymphatic_vessel1.29010800
52MP0003191_abnormal_cellular_cholesterol1.27539806
53MP0002396_abnormal_hematopoietic_system1.27164560
54MP0004510_myositis1.26998517
55MP0005670_abnormal_white_adipose1.25603579
56MP0002132_abnormal_respiratory_system1.25045107
57MP0000013_abnormal_adipose_tissue1.23730894
58MP0010352_gastrointestinal_tract_polyps1.23531570
59MP0001666_abnormal_nutrient_absorption1.23482453
60MP0000358_abnormal_cell_content/1.22040143
61MP0003693_abnormal_embryo_hatching1.18912746
62MP0004808_abnormal_hematopoietic_stem1.18307753
63MP0008438_abnormal_cutaneous_collagen1.15624087
64MP0002089_abnormal_postnatal_growth/wei1.14905601
65MP0009379_abnormal_foot_pigmentation1.10043285
66MP0004957_abnormal_blastocyst_morpholog1.09623378
67MP0004147_increased_porphyrin_level1.08695114
68MP0008260_abnormal_autophagy1.08356436
69MP0002127_abnormal_cardiovascular_syste1.07885100
70MP0000266_abnormal_heart_morphology1.04970835
71MP0003828_pulmonary_edema1.03790423
72MP0010368_abnormal_lymphatic_system1.01172488
73MP0002332_abnormal_exercise_endurance0.97607419
74MP0005360_urolithiasis0.97511043
75MP0005365_abnormal_bile_salt0.97319766
76MP0005058_abnormal_lysosome_morphology0.95697960
77MP0005266_abnormal_metabolism0.95672212
78MP0003868_abnormal_feces_composition0.94681649
79MP0005023_abnormal_wound_healing0.93684915
80MP0004264_abnormal_extraembryonic_tissu0.91133870
81MP0001348_abnormal_lacrimal_gland0.90855374
82MP0000733_abnormal_muscle_development0.89562712
83MP0003879_abnormal_hair_cell0.86708647
84MP0003091_abnormal_cell_migration0.84777392
85MP0005085_abnormal_gallbladder_physiolo0.81727909
86MP0002796_impaired_skin_barrier0.81572304
87MP0003453_abnormal_keratinocyte_physiol0.79993776
88MP0005623_abnormal_meninges_morphology0.79875658
89MP0000762_abnormal_tongue_morphology0.79563318
90MP0003252_abnormal_bile_duct0.78694726
91MP0002108_abnormal_muscle_morphology0.78463125
92MP0003566_abnormal_cell_adhesion0.77890971
93MP0005666_abnormal_adipose_tissue0.77521513
94MP0005275_abnormal_skin_tensile0.76664418
95MP0010329_abnormal_lipoprotein_level0.76581057
96MP0000343_altered_response_to0.76463648
97MP0004185_abnormal_adipocyte_glucose0.76240188
98MP0001915_intracranial_hemorrhage0.75054573
99MP0001849_ear_inflammation0.73920735
100MP0002166_altered_tumor_susceptibility0.72803955
101MP0002896_abnormal_bone_mineralization0.72425014
102MP0005165_increased_susceptibility_to0.72311996
103MP0002060_abnormal_skin_morphology0.71671905
104MP0001730_embryonic_growth_arrest0.69730420
105MP0000858_altered_metastatic_potential0.69347357
106MP0003122_maternal_imprinting0.68884406
107MP0003941_abnormal_skin_development0.68224921
108MP0002078_abnormal_glucose_homeostasis0.68106779
109MP0009384_cardiac_valve_regurgitation0.67866484
110MP0005083_abnormal_biliary_tract0.67067807
111MP0002080_prenatal_lethality0.66065122
112MP0005464_abnormal_platelet_physiology0.62968156
113MP0002128_abnormal_blood_circulation0.62612777
114MP0005375_adipose_tissue_phenotype0.62556365
115MP0005319_abnormal_enzyme/_coenzyme0.62375350
116MP0003984_embryonic_growth_retardation0.61280037
117MP0010094_abnormal_chromosome_stability0.60199046
118MP0002971_abnormal_brown_adipose0.60068164
119MP0001697_abnormal_embryo_size0.59658160
120MP0002088_abnormal_embryonic_growth/wei0.58994656
121MP0003656_abnormal_erythrocyte_physiolo0.58195368
122MP0000003_abnormal_adipose_tissue0.58123346
123MP0005220_abnormal_exocrine_pancreas0.55891428
124MP0001346_abnormal_lacrimal_gland0.54719847
125MP0003283_abnormal_digestive_organ0.54382084
126MP0002970_abnormal_white_adipose0.53823961
127MP0008770_decreased_survivor_rate0.52785467
128MP0000678_abnormal_parathyroid_gland0.51862441
129MP0001545_abnormal_hematopoietic_system0.51080297
130MP0005397_hematopoietic_system_phenotyp0.51080297
131MP0005187_abnormal_penis_morphology0.49818963
132MP0003959_abnormal_lean_body0.48003485
133MP0003077_abnormal_cell_cycle0.47633007
134MP0000230_abnormal_systemic_arterial0.47277296
135MP0003111_abnormal_nucleus_morphology0.47064404
136MP0005503_abnormal_tendon_morphology0.46664720
137MP0004197_abnormal_fetal_growth/weight/0.45750026
138MP0001944_abnormal_pancreas_morphology0.45560065
139MP0000313_abnormal_cell_death0.45389637
140MP0003172_abnormal_lysosome_physiology0.44507207
141MP0004858_abnormal_nervous_system0.44342462
142MP0008007_abnormal_cellular_replicative0.43214119
143MP0000372_irregular_coat_pigmentation0.42610326

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced muscle cramps (HP:0003710)5.32410524
2Exercise-induced myalgia (HP:0003738)4.91294806
3Sudden death (HP:0001699)4.84841309
4Myoglobinuria (HP:0002913)4.80376715
5Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.41250853
6Distal lower limb muscle weakness (HP:0009053)4.29620138
7Calf muscle hypertrophy (HP:0008981)4.14596130
8Rhabdomyolysis (HP:0003201)3.99289118
9Muscle hypertrophy of the lower extremities (HP:0008968)3.97011748
10Asymmetric septal hypertrophy (HP:0001670)3.87520307
11Abnormality of the left ventricular outflow tract (HP:0011103)3.87018751
12Subaortic stenosis (HP:0001682)3.87018751
13Ventricular tachycardia (HP:0004756)3.79576962
14Ragged-red muscle fibers (HP:0003200)3.63266829
15Myotonia (HP:0002486)3.61612562
16Abnormal atrioventricular conduction (HP:0005150)3.60143363
17Type 1 muscle fiber predominance (HP:0003803)3.55729713
18Nasal polyposis (HP:0100582)3.54834098
19Muscle fiber inclusion bodies (HP:0100299)3.54536623
20Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.49786953
21Abnormality of the calf musculature (HP:0001430)3.49236656
22Muscle fiber splitting (HP:0003555)3.47027740
23EMG: myopathic abnormalities (HP:0003458)3.45995878
24Palpitations (HP:0001962)3.42223764
25Rhinitis (HP:0012384)3.40686237
26Lipoatrophy (HP:0100578)3.40049917
27Deep venous thrombosis (HP:0002625)3.34981182
28Hepatic necrosis (HP:0002605)3.29221228
29Distal arthrogryposis (HP:0005684)3.27486844
30Increased connective tissue (HP:0009025)3.26785974
31Progressive muscle weakness (HP:0003323)3.25566379
32Difficulty climbing stairs (HP:0003551)3.22748177
33Abnormal respiratory motile cilium physiology (HP:0012261)3.20994011
34Decreased activity of mitochondrial respiratory chain (HP:0008972)3.19140933
35Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.19140933
36Atrial fibrillation (HP:0005110)3.19096145
37Hepatocellular necrosis (HP:0001404)3.18145510
38Supraventricular tachycardia (HP:0004755)3.16187412
39Increased muscle lipid content (HP:0009058)3.12144793
40Increased intramyocellular lipid droplets (HP:0012240)3.11888375
41Supraventricular arrhythmia (HP:0005115)3.11613417
42Protrusio acetabuli (HP:0003179)3.09055316
43Muscle stiffness (HP:0003552)3.07472418
44Hyporeflexia of lower limbs (HP:0002600)3.07470924
45Primary atrial arrhythmia (HP:0001692)3.07084444
46Abnormality of the nasal mucosa (HP:0000433)3.05805402
47Dilated cardiomyopathy (HP:0001644)3.00571628
48Nemaline bodies (HP:0003798)2.93478731
49Abnormal respiratory motile cilium morphology (HP:0005938)2.89537831
50Abnormal respiratory epithelium morphology (HP:0012253)2.89537831
51Abnormal mitochondria in muscle tissue (HP:0008316)2.88625686
52Limb-girdle muscle atrophy (HP:0003797)2.85999571
53Abnormality of cells of the erythroid lineage (HP:0012130)2.79638679
54Abnormal ciliary motility (HP:0012262)2.79260591
55Abnormality of alanine metabolism (HP:0010916)2.73877278
56Hyperalaninemia (HP:0003348)2.73877278
57Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.73877278
58Exercise intolerance (HP:0003546)2.68251561
59Mitochondrial inheritance (HP:0001427)2.66128053
60Ventricular arrhythmia (HP:0004308)2.65725391
61Difficulty running (HP:0009046)2.60762608
62Abnormal number of erythroid precursors (HP:0012131)2.59752213
63Increased CSF lactate (HP:0002490)2.59656428
64Ventricular fibrillation (HP:0001663)2.58884118
65Myopathic facies (HP:0002058)2.58386947
66Dynein arm defect of respiratory motile cilia (HP:0012255)2.56582712
67Absent/shortened dynein arms (HP:0200106)2.56582712
68Acute necrotizing encephalopathy (HP:0006965)2.56305510
69Rimmed vacuoles (HP:0003805)2.54869576
70Ketoacidosis (HP:0001993)2.49975603
71Centrally nucleated skeletal muscle fibers (HP:0003687)2.49253271
72Lactic acidosis (HP:0003128)2.49030871
73Prolonged QT interval (HP:0001657)2.46449869
74Increased variability in muscle fiber diameter (HP:0003557)2.45212405
75Abnormality of skeletal muscle fiber size (HP:0012084)2.43977586
76Bundle branch block (HP:0011710)2.40171745
77Chronic bronchitis (HP:0004469)2.39921641
78Syncope (HP:0001279)2.36544768
79Ulnar deviation of the wrist (HP:0003049)2.33266503
80Round ear (HP:0100830)2.32912298
81Increased serum lactate (HP:0002151)2.29518267
82Abnormality of the Achilles tendon (HP:0005109)2.27472173
83Areflexia of lower limbs (HP:0002522)2.27129318
84Neck muscle weakness (HP:0000467)2.26630711
85Aplastic anemia (HP:0001915)2.26087673
86Right ventricular cardiomyopathy (HP:0011663)2.25880130
87Bronchiectasis (HP:0002110)2.23110902
88Distal lower limb amyotrophy (HP:0008944)2.21790499
89Male infertility (HP:0003251)2.21419784
90Hypoglycemic coma (HP:0001325)2.21028742
91Abnormality of the tricuspid valve (HP:0001702)2.16923875
92Abnormality of aromatic amino acid family metabolism (HP:0004338)2.13810180
93Acute encephalopathy (HP:0006846)2.12780039
94Lipid accumulation in hepatocytes (HP:0006561)2.12443464
95Abnormality of the foot musculature (HP:0001436)2.12148518
96Calcaneovalgus deformity (HP:0001848)2.11653735
97Sudden cardiac death (HP:0001645)2.10935344
98Shoulder girdle muscle weakness (HP:0003547)2.10188981
99Mildly elevated creatine phosphokinase (HP:0008180)2.09583440
100Abnormal EKG (HP:0003115)2.08591286
101Reduced subcutaneous adipose tissue (HP:0003758)2.08249184
102Neoplasm of the adrenal gland (HP:0100631)2.07640296
103Flat acetabular roof (HP:0003180)2.06475250
104Conjunctival hamartoma (HP:0100780)2.04513605
105Pelvic girdle muscle weakness (HP:0003749)2.03292774
106Abnormality of monocarboxylic acid metabolism (HP:0010996)2.01136345
107Achilles tendon contracture (HP:0001771)2.01036148
108Foot dorsiflexor weakness (HP:0009027)2.00932552
109Scapular winging (HP:0003691)1.98722868
110Abnormality of the hip-girdle musculature (HP:0001445)1.98295930
111Abnormality of the musculature of the pelvis (HP:0001469)1.98295930
112Abnormality of glycolysis (HP:0004366)1.98182246
113Increased serum pyruvate (HP:0003542)1.98182246
114Vascular calcification (HP:0004934)1.97825548
115Atrioventricular block (HP:0001678)1.95112025
116Abnormality of the common coagulation pathway (HP:0010990)1.93784982
117Increased hepatocellular lipid droplets (HP:0006565)1.93498516
118Progressive macrocephaly (HP:0004481)1.93405527
119Atelectasis (HP:0100750)1.93026159
120Pheochromocytoma (HP:0002666)1.92503480
121Heart block (HP:0012722)1.92168219
122Thrombocytosis (HP:0001894)1.91788134
123Deformed tarsal bones (HP:0008119)1.91465039
124Esophageal neoplasm (HP:0100751)1.91143506
125Neoplasm of head and neck (HP:0012288)1.91143506
126Late onset (HP:0003584)1.91056212
127Abnormality of carpal bone ossification (HP:0006257)1.90033487
128EMG: neuropathic changes (HP:0003445)1.89706299
129Skin nodule (HP:0200036)1.88750161
130Adenoma sebaceum (HP:0009720)1.87785357
131Angiofibromas (HP:0010615)1.87785357
132Limb-girdle muscle weakness (HP:0003325)1.87652474
133Cardiovascular calcification (HP:0011915)1.86382507
134Prolonged partial thromboplastin time (HP:0003645)1.82897466
135Mitral stenosis (HP:0001718)1.82769703
136Transposition of the great arteries (HP:0001669)1.81246721
137Abnormal connection of the cardiac segments (HP:0011545)1.81246721
138Abnormal ventriculo-arterial connection (HP:0011563)1.81246721
139Joint hemorrhage (HP:0005261)1.76637792
140Menorrhagia (HP:0000132)1.73753547
141Complement deficiency (HP:0004431)1.71849182
142Arterial tortuosity (HP:0005116)1.70869712
143Resting tremor (HP:0002322)1.65838881
144Elbow flexion contracture (HP:0002987)1.62984043
145Upper limb amyotrophy (HP:0009129)1.62845278
146Distal upper limb amyotrophy (HP:0007149)1.62845278
147Palmoplantar keratoderma (HP:0000982)1.62577526

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PKN24.18939322
2TTN3.86756204
3TRIB33.66960125
4OBSCN3.18695677
5NEK13.05563829
6BCKDK2.91768610
7PHKG12.67726572
8PHKG22.67726572
9EPHA22.47997963
10NME22.33380198
11MST1R2.28137278
12SCYL22.14327046
13NME12.09044404
14TGFBR12.07871165
15LMTK22.04585287
16PDK41.89722513
17PDK31.89722513
18WEE11.88159094
19ILK1.83167108
20MAP2K31.79213283
21MYLK1.78959551
22CAMKK21.78606938
23MUSK1.72552148
24EEF2K1.68083785
25FLT31.62557623
26PASK1.59773048
27ICK1.54617742
28MAP3K111.50062351
29TRPM71.44506659
30MST41.43676661
31TIE11.43143120
32PTK21.42540113
33MAPKAPK31.41760453
34MAPK151.40356858
35MOS1.36109372
36KDR1.35279410
37ERN11.34521105
38PRPF4B1.33284974
39MAP3K21.26058017
40RPS6KB21.23523008
41CAMKK11.23343690
42FGFR41.22083314
43LIMK11.19678749
44LRRK21.18762258
45ZAP701.18543936
46EIF2AK11.15654290
47PIM21.14536904
48MAP2K61.14238661
49MET1.10108338
50STK241.04675836
51TESK11.03166924
52DMPK1.02028799
53PIK3CA1.00083825
54BRSK20.97007721
55PRKG20.96040404
56MAP3K60.93977165
57EIF2AK30.93196185
58IRAK30.89403359
59STK100.86634151
60DAPK30.82199995
61FGFR30.82101492
62CAMK10.80978218
63GRK70.80898522
64PINK10.80726480
65NTRK10.78552040
66MAP3K70.78543840
67MINK10.75042670
68PRKAA20.74671868
69RAF10.74158908
70PIK3CG0.73003912
71PDPK10.71785172
72LATS20.71630432
73KSR20.71471823
74RPS6KA40.69658802
75STK40.69362372
76MARK20.66838072
77MAP3K120.65391865
78DYRK30.64785983
79PAK40.64238928
80MAP2K40.64163125
81BRSK10.63413599
82STK160.63223945
83ROCK20.63176595
84TAOK10.61311597
85MAPK120.61099972
86STK380.60135335
87MAP3K100.58679195
88CAMK2G0.58642005
89BUB10.57511475
90EPHB10.57271831
91TESK20.56873322
92ROCK10.56243869
93PAK20.55653278
94PDK10.53523554
95AKT20.52840884
96PRKAA10.52595690
97PDGFRA0.52341202
98MAP3K90.50021135
99TGFBR20.49102799
100ERBB30.48196316
101PTK60.48044453
102BRAF0.46060756
103MAP3K50.46052994
104MTOR0.45888775
105ARAF0.45667885
106RET0.45198121
107NEK90.45171990
108ERBB40.44968795
109ACVR1B0.44866433
110LATS10.44707328
111MAP3K10.43009359
112PAK30.41689139
113CAMK2D0.41673400
114CDC70.41661639
115RIPK10.41536720
116CDC42BPA0.41152885
117CDK80.40864164
118TAOK20.40764363
119MAP2K10.39934944
120CCNB10.39740481
121MAP3K30.38936406
122CDK190.38849170
123DAPK10.38412844
124MAP3K80.37789830
125PAK10.37274940
126TAOK30.37212895
127VRK10.37149605
128PDK20.36789981
129ZAK0.34634275
130PRKD30.34586806
131CAMK40.34320035
132PTK2B0.33640570
133PAK60.33512773
134DDR20.31290012
135PRKD10.31148039
136GRK50.31017859
137FER0.30659111
138MAPK110.29844070
139AURKA0.29508484
140CDK70.29502535
141KSR10.27956094
142KIT0.27469226
143CDK40.27242358
144NEK60.26660616

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.44925502
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.64489884
3Ribosome_Homo sapiens_hsa030103.45610551
4Cardiac muscle contraction_Homo sapiens_hsa042603.26929413
5Phenylalanine metabolism_Homo sapiens_hsa003603.16369630
6Parkinsons disease_Homo sapiens_hsa050123.12677847
7Oxidative phosphorylation_Homo sapiens_hsa001902.67806621
8Carbon metabolism_Homo sapiens_hsa012002.46500961
9DNA replication_Homo sapiens_hsa030302.41105404
10Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.19931068
11Dilated cardiomyopathy_Homo sapiens_hsa054142.16974935
12Alzheimers disease_Homo sapiens_hsa050102.10323203
13Biosynthesis of amino acids_Homo sapiens_hsa012301.99633288
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.98835794
15Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.95718491
16Huntingtons disease_Homo sapiens_hsa050161.94914502
17Tyrosine metabolism_Homo sapiens_hsa003501.91421478
18Galactose metabolism_Homo sapiens_hsa000521.90654640
19Arginine biosynthesis_Homo sapiens_hsa002201.87282613
20Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.81767293
21Proteasome_Homo sapiens_hsa030501.76153433
22Complement and coagulation cascades_Homo sapiens_hsa046101.73431667
23Mismatch repair_Homo sapiens_hsa034301.71856614
24Pyruvate metabolism_Homo sapiens_hsa006201.66216000
25Propanoate metabolism_Homo sapiens_hsa006401.57293787
26Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.45153522
27Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.40612742
28PPAR signaling pathway_Homo sapiens_hsa033201.35022641
29Sulfur relay system_Homo sapiens_hsa041221.33960073
30Fatty acid degradation_Homo sapiens_hsa000711.33382762
31Pentose phosphate pathway_Homo sapiens_hsa000301.31535766
32ECM-receptor interaction_Homo sapiens_hsa045121.31207214
33Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.28237053
34Fructose and mannose metabolism_Homo sapiens_hsa000511.27808569
35Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.27166355
36Central carbon metabolism in cancer_Homo sapiens_hsa052301.23681544
37Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.23374940
38One carbon pool by folate_Homo sapiens_hsa006701.19514388
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.16656477
40Histidine metabolism_Homo sapiens_hsa003401.15080726
41Glucagon signaling pathway_Homo sapiens_hsa049221.15020743
42Pyrimidine metabolism_Homo sapiens_hsa002401.14129791
43Adherens junction_Homo sapiens_hsa045201.11151457
44Starch and sucrose metabolism_Homo sapiens_hsa005001.09456607
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.08576310
46Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.06177810
47Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.05821204
48RNA transport_Homo sapiens_hsa030131.03471043
49Base excision repair_Homo sapiens_hsa034101.03097234
50Cysteine and methionine metabolism_Homo sapiens_hsa002701.01737295
51Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.01490472
52N-Glycan biosynthesis_Homo sapiens_hsa005100.99146518
53Chemical carcinogenesis_Homo sapiens_hsa052040.98316470
54Nucleotide excision repair_Homo sapiens_hsa034200.97805824
55Insulin signaling pathway_Homo sapiens_hsa049100.97201722
56beta-Alanine metabolism_Homo sapiens_hsa004100.94188573
57Protein export_Homo sapiens_hsa030600.91252393
58Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.90537000
59Pancreatic cancer_Homo sapiens_hsa052120.89650823
60Spliceosome_Homo sapiens_hsa030400.88917605
61HIF-1 signaling pathway_Homo sapiens_hsa040660.87807529
62Bile secretion_Homo sapiens_hsa049760.84366958
63Viral myocarditis_Homo sapiens_hsa054160.83947332
64Glycosaminoglycan degradation_Homo sapiens_hsa005310.81240368
65Prion diseases_Homo sapiens_hsa050200.80858752
66Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.80410559
67Glutathione metabolism_Homo sapiens_hsa004800.76508681
68Tight junction_Homo sapiens_hsa045300.75793610
69Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.73783467
70RNA polymerase_Homo sapiens_hsa030200.73702765
71RNA degradation_Homo sapiens_hsa030180.73286728
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.70482551
73Insulin resistance_Homo sapiens_hsa049310.70111335
74Non-small cell lung cancer_Homo sapiens_hsa052230.70084826
75Purine metabolism_Homo sapiens_hsa002300.70078614
76Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.68579773
77Fatty acid metabolism_Homo sapiens_hsa012120.68457507
78Selenocompound metabolism_Homo sapiens_hsa004500.67453624
79Renal cell carcinoma_Homo sapiens_hsa052110.66784084
80Proteoglycans in cancer_Homo sapiens_hsa052050.65896417
81Oxytocin signaling pathway_Homo sapiens_hsa049210.65633055
82Insulin secretion_Homo sapiens_hsa049110.64584786
83AMPK signaling pathway_Homo sapiens_hsa041520.64284450
84Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.63830632
85Other glycan degradation_Homo sapiens_hsa005110.63594422
86Leukocyte transendothelial migration_Homo sapiens_hsa046700.61564155
87Amoebiasis_Homo sapiens_hsa051460.59882372
88Drug metabolism - other enzymes_Homo sapiens_hsa009830.59837649
89Vibrio cholerae infection_Homo sapiens_hsa051100.59085972
90Adipocytokine signaling pathway_Homo sapiens_hsa049200.56733365
91cGMP-PKG signaling pathway_Homo sapiens_hsa040220.55457876
92Chronic myeloid leukemia_Homo sapiens_hsa052200.53597127
93Homologous recombination_Homo sapiens_hsa034400.53011951
94Glioma_Homo sapiens_hsa052140.52826047
95Endometrial cancer_Homo sapiens_hsa052130.52612224
96Endocytosis_Homo sapiens_hsa041440.51193525
97Small cell lung cancer_Homo sapiens_hsa052220.51127237
98Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.49781372
99Thyroid cancer_Homo sapiens_hsa052160.49218583
100Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48324289
101Aldosterone synthesis and secretion_Homo sapiens_hsa049250.46491305
102Cell cycle_Homo sapiens_hsa041100.46224080
103Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.45839822
104Primary bile acid biosynthesis_Homo sapiens_hsa001200.45540911
105Pancreatic secretion_Homo sapiens_hsa049720.45291883
106Arginine and proline metabolism_Homo sapiens_hsa003300.44976245
107Calcium signaling pathway_Homo sapiens_hsa040200.43882077
108Long-term potentiation_Homo sapiens_hsa047200.43788251
109Phosphatidylinositol signaling system_Homo sapiens_hsa040700.40570740
110Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40385689
111Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39534917
112Gastric acid secretion_Homo sapiens_hsa049710.39527552
113Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.39221757
114Pentose and glucuronate interconversions_Homo sapiens_hsa000400.38844526
115Thyroid hormone synthesis_Homo sapiens_hsa049180.38493252
116Gap junction_Homo sapiens_hsa045400.38029674
117Metabolic pathways_Homo sapiens_hsa011000.37955506
118ABC transporters_Homo sapiens_hsa020100.37337039
119Renin secretion_Homo sapiens_hsa049240.37119627
120Butanoate metabolism_Homo sapiens_hsa006500.36895935
121mTOR signaling pathway_Homo sapiens_hsa041500.36869943
122Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.36587357
123Platelet activation_Homo sapiens_hsa046110.36403955
124Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.36233124
125VEGF signaling pathway_Homo sapiens_hsa043700.36044791
126Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35723310
127Bladder cancer_Homo sapiens_hsa052190.35425599
128Focal adhesion_Homo sapiens_hsa045100.35283591
129Longevity regulating pathway - mammal_Homo sapiens_hsa042110.34781821
130Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.34459561
131Oocyte meiosis_Homo sapiens_hsa041140.33968050
132Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.33751356
133Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.33098753
134Folate biosynthesis_Homo sapiens_hsa007900.32938301
135Choline metabolism in cancer_Homo sapiens_hsa052310.32928105
136Peroxisome_Homo sapiens_hsa041460.32507517
137Vascular smooth muscle contraction_Homo sapiens_hsa042700.30338422
138Sphingolipid metabolism_Homo sapiens_hsa006000.30292768
139Maturity onset diabetes of the young_Homo sapiens_hsa049500.30093701
140Circadian rhythm_Homo sapiens_hsa047100.27165314
141Carbohydrate digestion and absorption_Homo sapiens_hsa049730.24738657
142Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.24468978
143GnRH signaling pathway_Homo sapiens_hsa049120.23890314
144Neurotrophin signaling pathway_Homo sapiens_hsa047220.20367907
145Circadian entrainment_Homo sapiens_hsa047130.19937776
146Thyroid hormone signaling pathway_Homo sapiens_hsa049190.19423126
147Acute myeloid leukemia_Homo sapiens_hsa052210.17787818
148Cyanoamino acid metabolism_Homo sapiens_hsa004600.17006872
149Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.13978233

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