SMYD3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a histone methyltransferase which functions in RNA polymerase II complexes by an interaction with a specific RNA helicase. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.51806268
2protein neddylation (GO:0045116)4.16827032
3ATP synthesis coupled proton transport (GO:0015986)3.89692759
4energy coupled proton transport, down electrochemical gradient (GO:0015985)3.89692759
5mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.74442367
6rRNA modification (GO:0000154)3.72764235
7chromatin remodeling at centromere (GO:0031055)3.72482011
8DNA replication checkpoint (GO:0000076)3.64138717
9regulation of meiosis I (GO:0060631)3.56010808
10DNA double-strand break processing (GO:0000729)3.55085544
11respiratory electron transport chain (GO:0022904)3.51550173
12tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.50464242
13RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.50464242
14establishment of protein localization to mitochondrial membrane (GO:0090151)3.49690989
15regulation of mitochondrial translation (GO:0070129)3.49546827
16electron transport chain (GO:0022900)3.47510197
17cullin deneddylation (GO:0010388)3.41799728
18rRNA methylation (GO:0031167)3.36927520
19protein deneddylation (GO:0000338)3.34058374
20telomere maintenance via semi-conservative replication (GO:0032201)3.28190853
21polyketide metabolic process (GO:0030638)3.25246533
22doxorubicin metabolic process (GO:0044598)3.25246533
23daunorubicin metabolic process (GO:0044597)3.25246533
24DNA strand elongation involved in DNA replication (GO:0006271)3.22535563
25histone exchange (GO:0043486)3.20828971
26inositol phosphate catabolic process (GO:0071545)3.19901899
27nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.17500528
28negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.17350537
29regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.15144402
30exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.14359773
31centriole replication (GO:0007099)3.14268764
32serotonin receptor signaling pathway (GO:0007210)3.08585324
33DNA catabolic process, exonucleolytic (GO:0000738)3.08453184
34oxidative phosphorylation (GO:0006119)3.07819460
35somatic hypermutation of immunoglobulin genes (GO:0016446)3.07041473
36somatic diversification of immune receptors via somatic mutation (GO:0002566)3.07041473
37chaperone-mediated protein transport (GO:0072321)3.06751086
38presynaptic membrane assembly (GO:0097105)3.06488446
39resolution of meiotic recombination intermediates (GO:0000712)3.05939402
40DNA strand elongation (GO:0022616)3.04397127
41purine nucleobase biosynthetic process (GO:0009113)3.03823832
42regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.03270458
43protein targeting to mitochondrion (GO:0006626)3.02905597
44pseudouridine synthesis (GO:0001522)2.97981588
45positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.97495734
46pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.97450077
47mitotic recombination (GO:0006312)2.96500888
48mismatch repair (GO:0006298)2.95900039
49inner mitochondrial membrane organization (GO:0007007)2.94043900
50tRNA aminoacylation for protein translation (GO:0006418)2.93180293
51inositol phosphate dephosphorylation (GO:0046855)2.92176909
52phosphorylated carbohydrate dephosphorylation (GO:0046838)2.92176909
53anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.90031655
54DNA replication-independent nucleosome assembly (GO:0006336)2.89518846
55DNA replication-independent nucleosome organization (GO:0034724)2.89518846
56telomere maintenance via recombination (GO:0000722)2.88512356
57synaptic vesicle exocytosis (GO:0016079)2.88119766
58regulation of cellular amino acid metabolic process (GO:0006521)2.86938466
59tRNA aminoacylation (GO:0043039)2.86570223
60amino acid activation (GO:0043038)2.86570223
61protein-cofactor linkage (GO:0018065)2.84889564
62negative regulation of ligase activity (GO:0051352)2.84884159
63negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.84884159
64establishment of integrated proviral latency (GO:0075713)2.84625726
65positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.83754904
66establishment of protein localization to mitochondrion (GO:0072655)2.82795644
67protein localization to mitochondrion (GO:0070585)2.81784155
68protein K6-linked ubiquitination (GO:0085020)2.81004563
69negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.80634874
70negative regulation of synaptic transmission, GABAergic (GO:0032229)2.79243459
71protein complex biogenesis (GO:0070271)2.79214527
72synapsis (GO:0007129)2.78845361
73neuron cell-cell adhesion (GO:0007158)2.77410508
74positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.76684104
75postsynaptic membrane organization (GO:0001941)2.76445029
76nucleobase biosynthetic process (GO:0046112)2.75689380
77nucleotide-excision repair, DNA gap filling (GO:0006297)2.74594181
78protein localization to synapse (GO:0035418)2.73988659
79DNA damage response, detection of DNA damage (GO:0042769)2.72613089
80positive regulation of ligase activity (GO:0051351)2.72401586
81pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.71935499
82regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.71195334
83kinetochore assembly (GO:0051382)2.70343283
84synaptic vesicle docking involved in exocytosis (GO:0016081)2.70342726
85microtubule depolymerization (GO:0007019)2.70270523
86synaptic vesicle endocytosis (GO:0048488)2.68159819
87positive regulation of neurotransmitter secretion (GO:0001956)2.67210044
88viral mRNA export from host cell nucleus (GO:0046784)2.66878077
89kinetochore organization (GO:0051383)2.66080371
90mitochondrial respiratory chain complex I assembly (GO:0032981)2.66043201
91NADH dehydrogenase complex assembly (GO:0010257)2.66043201
92mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.66043201
93intra-S DNA damage checkpoint (GO:0031573)2.65107838
94regulation of short-term neuronal synaptic plasticity (GO:0048172)2.64993893
95maturation of 5.8S rRNA (GO:0000460)2.64170532
96regulation of centriole replication (GO:0046599)2.62506923
97regulation of synaptic transmission, GABAergic (GO:0032228)2.62013212
98presynaptic membrane organization (GO:0097090)2.61155961
99dopamine transport (GO:0015872)2.60605069
100tRNA metabolic process (GO:0006399)2.59795148
101ribosomal small subunit assembly (GO:0000028)2.59445269
102negative regulation of neurotransmitter transport (GO:0051589)2.58042680
103peptidyl-histidine modification (GO:0018202)2.57779099
104L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.57548972
105transcription-coupled nucleotide-excision repair (GO:0006283)2.57079772
106synaptic transmission, glutamatergic (GO:0035249)2.56617824
107recombinational repair (GO:0000725)2.55818496
108double-strand break repair via homologous recombination (GO:0000724)2.55592882
109regulation of glutamate receptor signaling pathway (GO:1900449)2.54488337
110telomere maintenance via telomere lengthening (GO:0010833)2.54143751
111vocalization behavior (GO:0071625)2.54034725
112DNA ligation (GO:0006266)2.54034254
113DNA replication initiation (GO:0006270)2.53736632
114neuronal action potential propagation (GO:0019227)2.53716714
115DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.53616896
116mitochondrial respiratory chain complex assembly (GO:0033108)2.53135408
117signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.53071868
118signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.53071868
119signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.53071868
120replication fork processing (GO:0031297)2.52520043
121histone H2A acetylation (GO:0043968)2.52514331
122negative regulation of dendrite morphogenesis (GO:0050774)2.51842083
123neuron-neuron synaptic transmission (GO:0007270)2.50543426
124maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.49746544
125mannosylation (GO:0097502)2.45023555
126positive regulation of mitochondrial fission (GO:0090141)2.44682273
127ionotropic glutamate receptor signaling pathway (GO:0035235)2.42572176
128proteasome assembly (GO:0043248)2.41567455
129deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.41434491
130startle response (GO:0001964)2.41215855
131positive regulation of neurotransmitter transport (GO:0051590)2.39990325
132sympathetic nervous system development (GO:0048485)2.39341985
133protein localization to cilium (GO:0061512)2.36380413
134regulation of nuclear cell cycle DNA replication (GO:0033262)2.35181177
135regulation of neurotransmitter secretion (GO:0046928)2.35080147
136positive regulation of synaptic transmission, GABAergic (GO:0032230)2.35077352
137regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.34921303
138negative regulation of neurotransmitter secretion (GO:0046929)2.33676150
139positive regulation of membrane potential (GO:0045838)2.33177885
140regulation of long-term neuronal synaptic plasticity (GO:0048169)2.32844241
141DNA strand renaturation (GO:0000733)2.29780760
142G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.29322016
143transcription elongation from RNA polymerase III promoter (GO:0006385)2.29169110
144termination of RNA polymerase III transcription (GO:0006386)2.29169110
145positive regulation of uterine smooth muscle contraction (GO:0070474)2.27730822
146gamma-aminobutyric acid signaling pathway (GO:0007214)2.27698272
147glutamate secretion (GO:0014047)2.27377973
148neurotransmitter uptake (GO:0001504)2.27298963
149response to histamine (GO:0034776)2.27017307
150regulation of synaptic vesicle exocytosis (GO:2000300)2.26796017
151glutamate receptor signaling pathway (GO:0007215)2.26388870
152negative regulation of dendrite development (GO:2000171)2.24904354
153regulation of synaptic vesicle transport (GO:1902803)2.23974868
154cytochrome complex assembly (GO:0017004)2.21901224
155long-chain fatty acid biosynthetic process (GO:0042759)2.21471114
156CENP-A containing nucleosome assembly (GO:0034080)2.20354370
157respiratory chain complex IV assembly (GO:0008535)2.18594856
158neurotransmitter-gated ion channel clustering (GO:0072578)2.17650409
159transmission of nerve impulse (GO:0019226)2.16759918
160RNA capping (GO:0036260)2.16435620
1617-methylguanosine RNA capping (GO:0009452)2.16435620
162regulation of glutamate secretion (GO:0014048)2.16319283
163regulation of neurotransmitter transport (GO:0051588)2.14172708
164dendrite development (GO:0016358)2.12688471
165regulation of excitatory postsynaptic membrane potential (GO:0060079)2.11973186
166negative regulation of DNA-dependent DNA replication (GO:2000104)2.10897141
167mechanosensory behavior (GO:0007638)2.08463916
168positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.07466874
169developmental pigmentation (GO:0048066)2.07245261
170auditory receptor cell stereocilium organization (GO:0060088)2.07099527
171catecholamine transport (GO:0051937)2.07074875
172serotonin metabolic process (GO:0042428)2.06705609
173transcription elongation from RNA polymerase I promoter (GO:0006362)2.05379885
174maturation of SSU-rRNA (GO:0030490)2.03896752
175regulation of postsynaptic membrane potential (GO:0060078)2.03640862
176regulation of synaptic transmission, glutamatergic (GO:0051966)2.03511656
1777-methylguanosine mRNA capping (GO:0006370)2.03184330
178establishment of synaptic vesicle localization (GO:0097480)2.03159034
179synaptic vesicle transport (GO:0048489)2.03159034
180deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.02834780
181viral protein processing (GO:0019082)2.01730381
182deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.01601664
183N-acetylglucosamine metabolic process (GO:0006044)2.00956307

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.97980988
2EZH2_22144423_ChIP-Seq_EOC_Human3.94137744
3E2F7_22180533_ChIP-Seq_HELA_Human3.10476154
4CREB1_15753290_ChIP-ChIP_HEK293T_Human2.98000001
5MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.47940782
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.45870115
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.45400944
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.34867231
9* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.32783778
10TAF15_26573619_Chip-Seq_HEK293_Human2.27870338
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.26997828
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.23654015
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.21472455
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.20233027
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.18498771
16* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.13106047
17SMAD_19615063_ChIP-ChIP_OVARY_Human2.11866919
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.09093784
19FLI1_27457419_Chip-Seq_LIVER_Mouse2.07412740
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.06871455
21FUS_26573619_Chip-Seq_HEK293_Human2.04593377
22CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.04168517
23DCP1A_22483619_ChIP-Seq_HELA_Human2.03320650
24GABP_19822575_ChIP-Seq_HepG2_Human1.94779511
25EST1_17652178_ChIP-ChIP_JURKAT_Human1.94006114
26CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.92441860
27NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.92235194
28EWS_26573619_Chip-Seq_HEK293_Human1.91203271
29* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.90352594
30PCGF2_27294783_Chip-Seq_ESCs_Mouse1.86168517
31HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.82527953
32PADI4_21655091_ChIP-ChIP_MCF-7_Human1.82457732
33POU3F2_20337985_ChIP-ChIP_501MEL_Human1.80220042
34JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.75650739
35MYC_18940864_ChIP-ChIP_HL60_Human1.73675907
36* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.70595630
37MYC_19079543_ChIP-ChIP_MESCs_Mouse1.69007290
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.68078634
39SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.65457270
40GABP_17652178_ChIP-ChIP_JURKAT_Human1.64907993
41BMI1_23680149_ChIP-Seq_NPCS_Mouse1.64032213
42P300_19829295_ChIP-Seq_ESCs_Human1.63789100
43XRN2_22483619_ChIP-Seq_HELA_Human1.56499161
44IGF1R_20145208_ChIP-Seq_DFB_Human1.55853485
45ZNF274_21170338_ChIP-Seq_K562_Hela1.55208277
46* REST_21632747_ChIP-Seq_MESCs_Mouse1.52869691
47VDR_22108803_ChIP-Seq_LS180_Human1.52279042
48RNF2_27304074_Chip-Seq_NSC_Mouse1.47734956
49THAP11_20581084_ChIP-Seq_MESCs_Mouse1.46952516
50MYCN_18555785_ChIP-Seq_MESCs_Mouse1.46537259
51NOTCH1_21737748_ChIP-Seq_TLL_Human1.46442775
52PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.45293255
53SMAD4_21799915_ChIP-Seq_A2780_Human1.43990205
54* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.41677564
55* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40283453
56ELK1_19687146_ChIP-ChIP_HELA_Human1.39672289
57IRF1_19129219_ChIP-ChIP_H3396_Human1.39609317
58POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.38939126
59CTBP1_25329375_ChIP-Seq_LNCAP_Human1.38486162
60FOXP3_21729870_ChIP-Seq_TREG_Human1.38484734
61YY1_21170310_ChIP-Seq_MESCs_Mouse1.38052152
62* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.37751894
63CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35868480
64SALL1_21062744_ChIP-ChIP_HESCs_Human1.35357689
65JARID2_20064375_ChIP-Seq_MESCs_Mouse1.33519657
66VDR_23849224_ChIP-Seq_CD4+_Human1.33459154
67* NFE2_27457419_Chip-Seq_LIVER_Mouse1.32289335
68E2F1_21310950_ChIP-Seq_MCF-7_Human1.31519642
69GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30810743
70SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.30645232
71* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.29939622
72SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.29923391
73ETS1_20019798_ChIP-Seq_JURKAT_Human1.29449586
74PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.28873169
75E2F4_17652178_ChIP-ChIP_JURKAT_Human1.26955757
76KDM5A_27292631_Chip-Seq_BREAST_Human1.25154423
77EZH2_27304074_Chip-Seq_ESCs_Mouse1.23546203
78* MYC_18555785_ChIP-Seq_MESCs_Mouse1.22781802
79MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.22508105
80* NANOG_18555785_Chip-Seq_ESCs_Mouse1.20760331
81* SRF_21415370_ChIP-Seq_HL-1_Mouse1.19894709
82HOXB4_20404135_ChIP-ChIP_EML_Mouse1.19415887
83* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19225194
84* E2F1_18555785_Chip-Seq_ESCs_Mouse1.18897005
85FOXM1_23109430_ChIP-Seq_U2OS_Human1.17877408
86* STAT3_18555785_Chip-Seq_ESCs_Mouse1.17270723
87REST_18959480_ChIP-ChIP_MESCs_Mouse1.16711762
88* EZH2_27294783_Chip-Seq_NPCs_Mouse1.16641534
89* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.15713848
90* NMYC_18555785_Chip-Seq_ESCs_Mouse1.15702076
91ER_23166858_ChIP-Seq_MCF-7_Human1.14419081
92PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.14346919
93MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.13846825
94NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.13697743
95POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.12808262
96AR_21909140_ChIP-Seq_LNCAP_Human1.12115299
97CBX2_27304074_Chip-Seq_ESCs_Mouse1.12079460
98CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.11728378
99* P53_22387025_ChIP-Seq_ESCs_Mouse1.10453950
100CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.10051667
101* P300_18555785_Chip-Seq_ESCs_Mouse1.09538375
102POU5F1_16153702_ChIP-ChIP_HESCs_Human1.09331354
103* STAT3_23295773_ChIP-Seq_U87_Human1.09294849
104ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.07602899
105OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06167531
106* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.05894012
107ELF1_17652178_ChIP-ChIP_JURKAT_Human1.05343636
108* CMYC_18555785_Chip-Seq_ESCs_Mouse1.05334740
109LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.04757600
110NANOG_16153702_ChIP-ChIP_HESCs_Human1.03945736
111ZFX_18555785_ChIP-Seq_MESCs_Mouse1.03398801
112SOX2_16153702_ChIP-ChIP_HESCs_Human1.03314979
113TP53_22573176_ChIP-Seq_HFKS_Human1.03136556
114* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.02080088
115FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.01589931
116* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.01580777
117* TCF4_23295773_ChIP-Seq_U87_Human1.01381603
118DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.01283900
119ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.00749554
120FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.00351790
121SOX9_26525672_Chip-Seq_HEART_Mouse0.99762700
122E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.99599876
123TTF2_22483619_ChIP-Seq_HELA_Human0.98350596
124* SOX2_18555785_Chip-Seq_ESCs_Mouse0.97681294
125CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.97599547
126IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.97495047
127SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.97008614
128MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.95290509
129TP63_19390658_ChIP-ChIP_HaCaT_Human0.93939875
130TOP2B_26459242_ChIP-Seq_MCF-7_Human0.93563547
131HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.93277883
132* CTCF_18555785_Chip-Seq_ESCs_Mouse0.92337135
133ERG_20887958_ChIP-Seq_HPC-7_Mouse0.91449193
134ELK1_22589737_ChIP-Seq_MCF10A_Human0.91440912
135PCGF2_27294783_Chip-Seq_NPCs_Mouse0.91275634
136* OCT4_18555785_Chip-Seq_ESCs_Mouse0.90659051
137* KLF4_18555785_Chip-Seq_ESCs_Mouse0.90106526
138HTT_18923047_ChIP-ChIP_STHdh_Human0.89428079
139JUN_21703547_ChIP-Seq_K562_Human0.89412258
140TAL1_26923725_Chip-Seq_HPCs_Mouse0.88988344
141EED_16625203_ChIP-ChIP_MESCs_Mouse0.88062896
142IKZF1_21737484_ChIP-ChIP_HCT116_Human0.87551968
143SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.87320850
144CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.86984207
145BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.86291604
146EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.84818366
147TFEB_21752829_ChIP-Seq_HELA_Human0.80654666
148* SOX17_20123909_ChIP-Seq_XEN_Mouse0.80199715
149CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.78127293
150CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.76643968
151FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.76364756
152TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.75738884
153* PHF8_20622853_ChIP-Seq_HELA_Human0.75683468
154SALL4_22934838_ChIP-ChIP_CD34+_Human0.75413030
155RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.74683397
156* RBPJ_21746931_ChIP-Seq_IB4_Human0.72790311
157ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.72430733

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level4.20144372
2MP0003787_abnormal_imprinting3.45206253
3MP0008995_early_reproductive_senescence3.40340767
4MP0005646_abnormal_pituitary_gland3.33117579
5MP0001188_hyperpigmentation3.12449329
6MP0003880_abnormal_central_pattern2.86827627
7MP0005645_abnormal_hypothalamus_physiol2.85676708
8MP0004957_abnormal_blastocyst_morpholog2.78589218
9MP0001986_abnormal_taste_sensitivity2.72944412
10MP0003718_maternal_effect2.59150897
11MP0006292_abnormal_olfactory_placode2.55428893
12MP0004859_abnormal_synaptic_plasticity2.52316087
13MP0001968_abnormal_touch/_nociception2.49419165
14MP0008877_abnormal_DNA_methylation2.40208412
15MP0008932_abnormal_embryonic_tissue2.28733490
16MP0002735_abnormal_chemical_nociception2.28617265
17MP0003635_abnormal_synaptic_transmissio2.20810120
18MP0009046_muscle_twitch2.19225392
19MP0009745_abnormal_behavioral_response2.18606302
20MP0005423_abnormal_somatic_nervous2.16882367
21MP0002064_seizures2.05772565
22MP0002572_abnormal_emotion/affect_behav2.03956996
23MP0003186_abnormal_redox_activity1.99984157
24MP0006036_abnormal_mitochondrial_physio1.97057394
25MP0002272_abnormal_nervous_system1.96641489
26MP0006035_abnormal_mitochondrial_morpho1.94838493
27MP0002736_abnormal_nociception_after1.91046752
28MP0000015_abnormal_ear_pigmentation1.90968207
29MP0005409_darkened_coat_color1.88173455
30MP0002734_abnormal_mechanical_nocicepti1.86434563
31MP0006276_abnormal_autonomic_nervous1.85854711
32MP0002063_abnormal_learning/memory/cond1.85717393
33MP0001529_abnormal_vocalization1.83813478
34MP0004142_abnormal_muscle_tone1.81414566
35MP0003077_abnormal_cell_cycle1.77863454
36MP0004270_analgesia1.74631524
37MP0001486_abnormal_startle_reflex1.72347568
38MP0005084_abnormal_gallbladder_morpholo1.71696289
39MP0003121_genomic_imprinting1.71414745
40MP0008057_abnormal_DNA_replication1.67464362
41MP0002396_abnormal_hematopoietic_system1.65653427
42MP0008058_abnormal_DNA_repair1.62940204
43MP0010094_abnormal_chromosome_stability1.60042163
44MP0000358_abnormal_cell_content/1.56275214
45MP0005410_abnormal_fertilization1.55432865
46MP0001970_abnormal_pain_threshold1.52965317
47MP0001929_abnormal_gametogenesis1.52537131
48MP0001905_abnormal_dopamine_level1.52134304
49MP0002210_abnormal_sex_determination1.51660974
50MP0002938_white_spotting1.50394162
51MP0001984_abnormal_olfaction1.48754542
52MP0001501_abnormal_sleep_pattern1.48587495
53MP0001661_extended_life_span1.47715580
54MP0002067_abnormal_sensory_capabilities1.46306558
55MP0002638_abnormal_pupillary_reflex1.44602669
56MP0005075_abnormal_melanosome_morpholog1.43973479
57MP0003122_maternal_imprinting1.43427517
58MP0005174_abnormal_tail_pigmentation1.42196990
59MP0002733_abnormal_thermal_nociception1.42019252
60MP0004924_abnormal_behavior1.40819567
61MP0005386_behavior/neurological_phenoty1.40819567
62MP0005464_abnormal_platelet_physiology1.36755124
63MP0002557_abnormal_social/conspecific_i1.35196842
64MP0000653_abnormal_sex_gland1.31909253
65MP0000631_abnormal_neuroendocrine_gland1.27287145
66MP0008569_lethality_at_weaning1.26821572
67MP0000372_irregular_coat_pigmentation1.26658491
68MP0001293_anophthalmia1.26151397
69MP0000647_abnormal_sebaceous_gland1.23450917
70MP0009697_abnormal_copulation1.23429250
71MP0001145_abnormal_male_reproductive1.23153339
72MP0002160_abnormal_reproductive_system1.22573418
73MP0003763_abnormal_thymus_physiology1.22303828
74MP0008007_abnormal_cellular_replicative1.21723596
75MP0010386_abnormal_urinary_bladder1.20819309
76MP0003698_abnormal_male_reproductive1.19738023
77MP0002102_abnormal_ear_morphology1.19060123
78MP0009379_abnormal_foot_pigmentation1.18949560
79MP0005187_abnormal_penis_morphology1.18299806
80MP0003693_abnormal_embryo_hatching1.15056994
81MP0003806_abnormal_nucleotide_metabolis1.12937804
82MP0003656_abnormal_erythrocyte_physiolo1.12869243
83MP0002095_abnormal_skin_pigmentation1.11477863
84MP0008775_abnormal_heart_ventricle1.10366816
85MP0002184_abnormal_innervation1.10078935
86MP0005083_abnormal_biliary_tract1.09802486
87MP0003567_abnormal_fetal_cardiomyocyte1.08458595
88MP0008872_abnormal_physiological_respon1.07975411
89MP0002009_preneoplasia1.07905036
90MP0003879_abnormal_hair_cell1.07431080
91MP0001502_abnormal_circadian_rhythm1.06091745
92MP0002163_abnormal_gland_morphology1.05931859
93MP0001697_abnormal_embryo_size1.05703787
94MP0002822_catalepsy1.05241910
95MP0005671_abnormal_response_to1.05239080
96MP0002132_abnormal_respiratory_system1.04951689
97MP0005551_abnormal_eye_electrophysiolog1.02716406
98MP0005394_taste/olfaction_phenotype1.02090754
99MP0005499_abnormal_olfactory_system1.02090754
100MP0003937_abnormal_limbs/digits/tail_de1.00647873
101MP0002751_abnormal_autonomic_nervous1.00395168
102MP0002234_abnormal_pharynx_morphology0.98144450
103MP0005379_endocrine/exocrine_gland_phen0.95104223
104MP0006054_spinal_hemorrhage0.94635118
105MP0005389_reproductive_system_phenotype0.94390984
106MP0001485_abnormal_pinna_reflex0.94166170
107MP0001440_abnormal_grooming_behavior0.93023334
108MP0005171_absent_coat_pigmentation0.92986093
109MP0001730_embryonic_growth_arrest0.92405410
110MP0001119_abnormal_female_reproductive0.92174105
111MP0002876_abnormal_thyroid_physiology0.90530317
112MP0003136_yellow_coat_color0.90322753
113MP0004811_abnormal_neuron_physiology0.90304095
114MP0001764_abnormal_homeostasis0.88992752
115MP0004742_abnormal_vestibular_system0.88774015
116MP0006072_abnormal_retinal_apoptosis0.84622896
117MP0001919_abnormal_reproductive_system0.83548581
118MP0003786_premature_aging0.83192764
119MP0002084_abnormal_developmental_patter0.83086558
120MP0002090_abnormal_vision0.82576130
121MP0002837_dystrophic_cardiac_calcinosis0.81680246
122MP0002882_abnormal_neuron_morphology0.81464438
123MP0003045_fibrosis0.80509833
124MP0003123_paternal_imprinting0.80365355
125MP0002161_abnormal_fertility/fecundity0.79950330
126MP0000639_abnormal_adrenal_gland0.78918863
127MP0000350_abnormal_cell_proliferation0.78742287
128MP0005220_abnormal_exocrine_pancreas0.78333416
129MP0005408_hypopigmentation0.78256207
130MP0000778_abnormal_nervous_system0.78091471
131MP0008789_abnormal_olfactory_epithelium0.77371694
132MP0002233_abnormal_nose_morphology0.76677231
133MP0003119_abnormal_digestive_system0.76539925
134MP0002066_abnormal_motor_capabilities/c0.75513190
135MP0001963_abnormal_hearing_physiology0.74316063
136MP0005395_other_phenotype0.74215647
137MP0000955_abnormal_spinal_cord0.74196355
138MP0005253_abnormal_eye_physiology0.73758652
139MP0005332_abnormal_amino_acid0.73689928
140MP0003938_abnormal_ear_development0.73675441
141MP0002080_prenatal_lethality0.73305646
142MP0002085_abnormal_embryonic_tissue0.72984771
143MP0003633_abnormal_nervous_system0.72788896
144MP0001672_abnormal_embryogenesis/_devel0.72355572
145MP0005380_embryogenesis_phenotype0.72355572
146MP0009333_abnormal_splenocyte_physiolog0.71523428
147MP0003111_abnormal_nucleus_morphology0.70602479
148MP0000313_abnormal_cell_death0.70580491
149MP0002229_neurodegeneration0.70341697
150MP0000681_abnormal_thyroid_gland0.69821101
151MP0003385_abnormal_body_wall0.69479116
152MP0004133_heterotaxia0.68904619
153MP0005636_abnormal_mineral_homeostasis0.68304540
154MP0001835_abnormal_antigen_presentation0.67263197
155MP0008004_abnormal_stomach_pH0.64816692
156MP0002752_abnormal_somatic_nervous0.64699849

Predicted human phenotypes

RankGene SetZ-score
1Acute encephalopathy (HP:0006846)4.30123514
2Focal motor seizures (HP:0011153)3.94661001
3Increased CSF lactate (HP:0002490)3.74667851
4Febrile seizures (HP:0002373)3.68977154
5Abnormal hair whorl (HP:0010721)3.57993455
6Increased hepatocellular lipid droplets (HP:0006565)3.53427421
7Hypothermia (HP:0002045)3.42207613
8Hepatocellular necrosis (HP:0001404)3.40851581
9Birth length less than 3rd percentile (HP:0003561)3.38599565
10Renal Fanconi syndrome (HP:0001994)3.37626795
11Chromosomal breakage induced by crosslinking agents (HP:0003221)3.36957770
12Lipid accumulation in hepatocytes (HP:0006561)3.36362277
13Hepatic necrosis (HP:0002605)3.27532086
14Type 2 muscle fiber atrophy (HP:0003554)3.26024654
15Chromsome breakage (HP:0040012)3.25260441
16Pancreatic fibrosis (HP:0100732)3.00319410
17Muscle fiber atrophy (HP:0100295)2.94794212
18Cholecystitis (HP:0001082)2.90200972
19Abnormal gallbladder physiology (HP:0012438)2.90200972
20Cerebral edema (HP:0002181)2.86822717
21Increased serum lactate (HP:0002151)2.84969543
22Methylmalonic acidemia (HP:0002912)2.78186519
23Epileptic encephalopathy (HP:0200134)2.77141327
24Atonic seizures (HP:0010819)2.65002425
25Lactic acidosis (HP:0003128)2.63553324
26Aplastic anemia (HP:0001915)2.60607284
27Increased intramyocellular lipid droplets (HP:0012240)2.59116199
28Type I transferrin isoform profile (HP:0003642)2.54003348
29Abnormality of glycolysis (HP:0004366)2.52142197
30Abnormality of midbrain morphology (HP:0002418)2.51528440
31Molar tooth sign on MRI (HP:0002419)2.51528440
32True hermaphroditism (HP:0010459)2.50942593
33Abnormality of the preputium (HP:0100587)2.50581486
34Decreased activity of mitochondrial respiratory chain (HP:0008972)2.49861440
35Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.49861440
36Increased serum pyruvate (HP:0003542)2.46474865
37Pancreatic cysts (HP:0001737)2.41665554
38Protruding tongue (HP:0010808)2.36764702
39Abnormality of methionine metabolism (HP:0010901)2.35492720
40Exertional dyspnea (HP:0002875)2.34108464
41Methylmalonic aciduria (HP:0012120)2.31816200
42Hyperglycinemia (HP:0002154)2.29690005
43Respiratory failure (HP:0002878)2.28333906
44Abnormality of the renal collecting system (HP:0004742)2.24983478
45Median cleft lip (HP:0000161)2.23221701
46Renal cortical cysts (HP:0000803)2.22765801
47Exercise intolerance (HP:0003546)2.22636270
48Medial flaring of the eyebrow (HP:0010747)2.22270796
49Myokymia (HP:0002411)2.22068342
50Meckel diverticulum (HP:0002245)2.20925493
51Abnormality of the ileum (HP:0001549)2.20531061
52Aplasia/Hypoplasia of the uvula (HP:0010293)2.18913481
53Abnormality of the anterior horn cell (HP:0006802)2.15675683
54Degeneration of anterior horn cells (HP:0002398)2.15675683
55Focal seizures (HP:0007359)2.12780326
56Duplicated collecting system (HP:0000081)2.11795016
57Male pseudohermaphroditism (HP:0000037)2.10476710
58Clubbing of toes (HP:0100760)2.09776792
59Abnormality of the nasal septum (HP:0000419)2.09199170
60Abnormality of the pons (HP:0007361)2.08984177
61Hypoplasia of the pons (HP:0012110)2.08875570
62Reticulocytopenia (HP:0001896)2.07563440
63Gait imbalance (HP:0002141)2.07457681
64Abnormality of the labia minora (HP:0012880)2.06523715
65Abnormality of chromosome stability (HP:0003220)2.05460708
66Increased muscle lipid content (HP:0009058)2.02808576
67Progressive cerebellar ataxia (HP:0002073)2.02571718
683-Methylglutaconic aciduria (HP:0003535)2.02529541
69Nephrogenic diabetes insipidus (HP:0009806)2.01649056
70Fetal akinesia sequence (HP:0001989)2.00893082
71Abnormality of renal resorption (HP:0011038)2.00484386
72Abnormality of DNA repair (HP:0003254)1.99762098
73Rhabdomyosarcoma (HP:0002859)1.98357950
74Congenital primary aphakia (HP:0007707)1.97740331
75Myelodysplasia (HP:0002863)1.97096046
76Acute necrotizing encephalopathy (HP:0006965)1.96223411
77Pheochromocytoma (HP:0002666)1.95512127
78Astrocytoma (HP:0009592)1.93667213
79Abnormality of the astrocytes (HP:0100707)1.93667213
80Lethargy (HP:0001254)1.91965385
81Pancreatic islet-cell hyperplasia (HP:0004510)1.91060784
82Aganglionic megacolon (HP:0002251)1.89915521
8311 pairs of ribs (HP:0000878)1.88653964
84Dyschromatopsia (HP:0007641)1.88166724
85Respiratory difficulties (HP:0002880)1.88079590
86Tubulointerstitial nephritis (HP:0001970)1.88023844
87Absent thumb (HP:0009777)1.87854971
88Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.87767166
89Poor suck (HP:0002033)1.86402103
90Hyperthyroidism (HP:0000836)1.86244806
91Visual hallucinations (HP:0002367)1.86017973
92Truncus arteriosus (HP:0001660)1.85870093
93Abnormality of the heme biosynthetic pathway (HP:0010472)1.85601717
94Abnormality of serum amino acid levels (HP:0003112)1.84385000
95Abnormality of aspartate family amino acid metabolism (HP:0010899)1.83896543
96Sclerocornea (HP:0000647)1.80584168
97Abnormality of the duodenum (HP:0002246)1.80448317
98Preaxial hand polydactyly (HP:0001177)1.79536158
99Prostate neoplasm (HP:0100787)1.79163929
100Gonadotropin excess (HP:0000837)1.79017766
101Aqueductal stenosis (HP:0002410)1.78626305
102Gaze-evoked nystagmus (HP:0000640)1.78563720
103Neuroendocrine neoplasm (HP:0100634)1.78448138
104Bone marrow hypocellularity (HP:0005528)1.78412014
105Stomatitis (HP:0010280)1.77190510
106Abnormality of urine glucose concentration (HP:0011016)1.77190315
107Glycosuria (HP:0003076)1.77190315
108Petechiae (HP:0000967)1.76545930
109Breast hypoplasia (HP:0003187)1.75599890
110Abnormal mitochondria in muscle tissue (HP:0008316)1.75589765
111Fair hair (HP:0002286)1.75459773
112Abnormal protein glycosylation (HP:0012346)1.74762329
113Abnormal glycosylation (HP:0012345)1.74762329
114Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.74762329
115Abnormal protein N-linked glycosylation (HP:0012347)1.74762329
116Progressive macrocephaly (HP:0004481)1.74702660
117Aplasia/Hypoplasia of the tongue (HP:0010295)1.74591705
118Abnormal ciliary motility (HP:0012262)1.74383735
119Generalized hypopigmentation of hair (HP:0011358)1.73649126
120Asplenia (HP:0001746)1.73380257
121Horseshoe kidney (HP:0000085)1.72755086
122Septo-optic dysplasia (HP:0100842)1.71802095
123Optic nerve hypoplasia (HP:0000609)1.71798203
124Sloping forehead (HP:0000340)1.71379274
125Absent/shortened dynein arms (HP:0200106)1.71032506
126Dynein arm defect of respiratory motile cilia (HP:0012255)1.71032506
127CNS demyelination (HP:0007305)1.70528881
128Optic disc pallor (HP:0000543)1.70189986
129Postnatal microcephaly (HP:0005484)1.70117524
130Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.69692786
131Glioma (HP:0009733)1.68901009
132Nephroblastoma (Wilms tumor) (HP:0002667)1.68523739
133Mitochondrial inheritance (HP:0001427)1.68504919
134Leukodystrophy (HP:0002415)1.68472277
135Embryonal renal neoplasm (HP:0011794)1.68073016
136Upper limb muscle weakness (HP:0003484)1.68011049
137Chorioretinal coloboma (HP:0000567)1.67908032
138Chronic hepatic failure (HP:0100626)1.67658082
139Abnormal lung lobation (HP:0002101)1.67123868
140Dialeptic seizures (HP:0011146)1.66573422
141Nephronophthisis (HP:0000090)1.64776213
142Microvesicular hepatic steatosis (HP:0001414)1.64155844
143IgG deficiency (HP:0004315)1.64127051
144Inability to walk (HP:0002540)1.63507859
145Hypoplasia of the fovea (HP:0007750)1.63000674
146Aplasia/Hypoplasia of the fovea (HP:0008060)1.63000674
147Broad-based gait (HP:0002136)1.62590295
148Patchy hypopigmentation of hair (HP:0011365)1.61800699
149Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.61742545
150Abnormality of alanine metabolism (HP:0010916)1.61742545
151Hyperalaninemia (HP:0003348)1.61742545
152Small intestinal stenosis (HP:0012848)1.61716334
153Duodenal stenosis (HP:0100867)1.61716334
154Generalized tonic-clonic seizures (HP:0002069)1.61087536
155Hypoplasia of the capital femoral epiphysis (HP:0003090)1.60207828
156Agnosia (HP:0010524)1.59123566
157Pancytopenia (HP:0001876)1.58704572
158Poor coordination (HP:0002370)1.58431885

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B6.61213401
2CASK3.71922873
3STK163.70492009
4MST43.38457032
5MAP3K123.09860681
6MAP2K73.04517011
7TNIK2.76233577
8PBK2.41048507
9NEK12.28304269
10VRK22.27111380
11TRIM282.21174366
12MAP3K42.20360775
13MAP4K22.18712733
14TTK2.17767273
15SIK32.17268939
16NUAK12.16902636
17NTRK32.14730581
18VRK12.11826734
19LATS12.04503855
20MAPK131.94291093
21CDK191.80214541
22INSRR1.73263872
23ADRBK21.71950586
24BCKDK1.71293219
25TXK1.57926377
26SRPK11.48058842
27DAPK11.47968028
28WNK31.47505566
29TSSK61.41500888
30CCNB11.39480326
31FRK1.37933883
32NME21.36412998
33BMPR21.31342405
34CDK31.23278292
35CDK81.18729562
36ZAK1.13366141
37PDK21.10833001
38YES11.10667949
39GRK51.10241699
40BMPR1B1.08093436
41MAP3K61.07395821
42EPHA41.07162188
43WEE10.99783238
44ERBB30.96401074
45GRK10.94785707
46MINK10.94578193
47PLK20.92897692
48AKT30.92638796
49MAPKAPK50.92357539
50FES0.91619767
51RAF10.91384323
52CSNK1G30.89389120
53CHEK20.88281164
54CSNK1G20.87855709
55MKNK20.85773142
56TLK10.84248085
57FLT30.83458392
58GRK70.81719327
59NEK20.81559072
60TEC0.81183046
61MARK10.78985934
62IRAK40.78857828
63ATM0.77959663
64BUB10.77777646
65CAMKK20.76286796
66CSNK1G10.76088671
67TNK20.75270421
68DYRK20.74666850
69CDC70.74023776
70MUSK0.73079656
71AURKB0.72296933
72NTRK20.70785089
73MYLK0.69929815
74PLK30.69392551
75MAP2K40.68890799
76RIPK40.68710969
77STK30.68458983
78ILK0.68263581
79OXSR10.66256574
80MKNK10.65714087
81CSNK1A1L0.64818431
82PRKCG0.64660317
83SGK20.63672756
84CLK10.63642061
85DAPK20.63594049
86ACVR1B0.63211594
87TAOK30.62102389
88EIF2AK30.61401580
89PIK3CG0.61151527
90PAK30.61112581
91BMX0.61019559
92PAK10.58419688
93STK40.56957947
94NEK60.56348907
95CHEK10.55918408
96SCYL20.54617876
97EIF2AK20.52834353
98SIK20.52759610
99ADRBK10.52169126
100UHMK10.51614363
101TAF10.51227219
102DYRK1A0.48731432
103ATR0.48411211
104CAMK2A0.46591408
105PLK40.45922460
106PRKCE0.45770979
107SYK0.45107523
108CDK50.43513433
109MATK0.43118326
110CSNK1E0.42411362
111BCR0.42157806
112RPS6KA40.42107218
113BRSK10.41730568
114RPS6KA50.41097057
115WNK40.40850179
116NME10.40047424
117EIF2AK10.39860056
118KIT0.39346654
119PINK10.38676000
120PLK10.38190349
121BRAF0.37706011
122CDK180.37086673
123BRSK20.36602766
124CDK10.35557598
125CAMK10.35313835
126PNCK0.34667152
127TESK20.34375646
128MAP3K140.33923738
129CDK11A0.30180824
130ARAF0.29752520
131CSNK2A20.29667579
132LCK0.29507218
133RPS6KB10.29472903
134PTK2B0.29169361
135SGK2230.29047055
136SGK4940.29047055
137CDK150.28361349
138IRAK30.28352504
139IKBKB0.28042048
140CSNK2A10.27776142
141CDK20.27592981
142AURKA0.27041168
143LYN0.26805048
144PKN10.26595638
145PRKACB0.26057336
146CDK70.24613429

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.61520015
2One carbon pool by folate_Homo sapiens_hsa006702.32529322
3Mismatch repair_Homo sapiens_hsa034302.18745340
4Synaptic vesicle cycle_Homo sapiens_hsa047212.17499399
5DNA replication_Homo sapiens_hsa030302.15997834
6Homologous recombination_Homo sapiens_hsa034402.00344386
7RNA polymerase_Homo sapiens_hsa030201.90189423
8Morphine addiction_Homo sapiens_hsa050321.85903060
9Fatty acid elongation_Homo sapiens_hsa000621.85538062
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.83180416
11Taste transduction_Homo sapiens_hsa047421.79252268
12Fanconi anemia pathway_Homo sapiens_hsa034601.78383697
13Base excision repair_Homo sapiens_hsa034101.76376768
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.73115766
15Olfactory transduction_Homo sapiens_hsa047401.71175663
16Serotonergic synapse_Homo sapiens_hsa047261.71041667
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.70509430
18Propanoate metabolism_Homo sapiens_hsa006401.69649019
19Nucleotide excision repair_Homo sapiens_hsa034201.66447417
20Ribosome_Homo sapiens_hsa030101.63848360
21Basal transcription factors_Homo sapiens_hsa030221.61254456
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.61220905
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.61060945
24Collecting duct acid secretion_Homo sapiens_hsa049661.57320446
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.55926364
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.55722551
27Proteasome_Homo sapiens_hsa030501.55106097
28GABAergic synapse_Homo sapiens_hsa047271.54102289
29Protein export_Homo sapiens_hsa030601.53495344
30Circadian entrainment_Homo sapiens_hsa047131.51552179
31Steroid biosynthesis_Homo sapiens_hsa001001.46317365
32SNARE interactions in vesicular transport_Homo sapiens_hsa041301.45935997
33Non-homologous end-joining_Homo sapiens_hsa034501.42192917
34Glutamatergic synapse_Homo sapiens_hsa047241.37900177
35Amphetamine addiction_Homo sapiens_hsa050311.33377812
36Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.30329844
37Glutathione metabolism_Homo sapiens_hsa004801.30218066
38Phototransduction_Homo sapiens_hsa047441.29534667
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.27957948
40Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.27881654
41Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.26227273
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.24247765
43Long-term potentiation_Homo sapiens_hsa047201.22933243
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.22497148
45Insulin secretion_Homo sapiens_hsa049111.21566344
46Pyruvate metabolism_Homo sapiens_hsa006201.21417929
47Dopaminergic synapse_Homo sapiens_hsa047281.18621743
48RNA degradation_Homo sapiens_hsa030181.17922496
49Primary immunodeficiency_Homo sapiens_hsa053401.17507519
50Spliceosome_Homo sapiens_hsa030401.15811244
51Oxidative phosphorylation_Homo sapiens_hsa001901.12944029
52Butanoate metabolism_Homo sapiens_hsa006501.12498858
53Cholinergic synapse_Homo sapiens_hsa047251.12296451
54Pyrimidine metabolism_Homo sapiens_hsa002401.12095253
55Purine metabolism_Homo sapiens_hsa002301.09137117
56Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.08039671
57Calcium signaling pathway_Homo sapiens_hsa040201.06668495
58Sulfur metabolism_Homo sapiens_hsa009201.03930905
59Cardiac muscle contraction_Homo sapiens_hsa042601.03863777
60Selenocompound metabolism_Homo sapiens_hsa004501.02453443
612-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.99828599
62Vitamin B6 metabolism_Homo sapiens_hsa007500.99005036
63Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.98979925
64Carbon metabolism_Homo sapiens_hsa012000.98664779
65Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.97836332
66Vibrio cholerae infection_Homo sapiens_hsa051100.95347749
67Parkinsons disease_Homo sapiens_hsa050120.95138550
68Biosynthesis of amino acids_Homo sapiens_hsa012300.94871199
69Salivary secretion_Homo sapiens_hsa049700.94545219
70Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.91861124
71Long-term depression_Homo sapiens_hsa047300.89760101
72Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.89231100
73Metabolic pathways_Homo sapiens_hsa011000.88573601
74Cell cycle_Homo sapiens_hsa041100.88402998
75Phosphatidylinositol signaling system_Homo sapiens_hsa040700.87430589
76Huntingtons disease_Homo sapiens_hsa050160.86659428
77Rheumatoid arthritis_Homo sapiens_hsa053230.86480602
78Type I diabetes mellitus_Homo sapiens_hsa049400.86346354
79Allograft rejection_Homo sapiens_hsa053300.85420928
80Nitrogen metabolism_Homo sapiens_hsa009100.81894170
81Folate biosynthesis_Homo sapiens_hsa007900.81669788
82Graft-versus-host disease_Homo sapiens_hsa053320.81399713
83Regulation of autophagy_Homo sapiens_hsa041400.80830893
84Autoimmune thyroid disease_Homo sapiens_hsa053200.80407976
85RNA transport_Homo sapiens_hsa030130.79747529
86Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.78195369
87Peroxisome_Homo sapiens_hsa041460.78024706
88Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.77725991
89Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.76157098
90Cocaine addiction_Homo sapiens_hsa050300.76088596
91Fatty acid metabolism_Homo sapiens_hsa012120.75374653
92T cell receptor signaling pathway_Homo sapiens_hsa046600.74919130
93Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.74672297
94Maturity onset diabetes of the young_Homo sapiens_hsa049500.72699501
95Alcoholism_Homo sapiens_hsa050340.71989890
96Oxytocin signaling pathway_Homo sapiens_hsa049210.69987950
97Oocyte meiosis_Homo sapiens_hsa041140.68542424
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.66970973
99GnRH signaling pathway_Homo sapiens_hsa049120.66215827
100Aldosterone synthesis and secretion_Homo sapiens_hsa049250.66141063
101Alzheimers disease_Homo sapiens_hsa050100.64921339
102Gap junction_Homo sapiens_hsa045400.63388340
103Primary bile acid biosynthesis_Homo sapiens_hsa001200.61604369
104Epstein-Barr virus infection_Homo sapiens_hsa051690.61345476
105Circadian rhythm_Homo sapiens_hsa047100.60845177
106Intestinal immune network for IgA production_Homo sapiens_hsa046720.59526759
107Renin secretion_Homo sapiens_hsa049240.59497227
108Measles_Homo sapiens_hsa051620.58324594
109Hematopoietic cell lineage_Homo sapiens_hsa046400.57128469
110Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55415145
111Asthma_Homo sapiens_hsa053100.55344584
112mRNA surveillance pathway_Homo sapiens_hsa030150.54138261
113Sphingolipid metabolism_Homo sapiens_hsa006000.53256098
114Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.53165892
115Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.52919168
116Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.52614180
117Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51550224
118ErbB signaling pathway_Homo sapiens_hsa040120.49792783
119cAMP signaling pathway_Homo sapiens_hsa040240.49036480
120Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.48303858
121Other glycan degradation_Homo sapiens_hsa005110.48262917
122Sulfur relay system_Homo sapiens_hsa041220.47741797
123Arginine and proline metabolism_Homo sapiens_hsa003300.46784037
124Gastric acid secretion_Homo sapiens_hsa049710.46729455
125Ras signaling pathway_Homo sapiens_hsa040140.46275856
126Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46263486
127Wnt signaling pathway_Homo sapiens_hsa043100.45869858
128MAPK signaling pathway_Homo sapiens_hsa040100.45414385
129Inositol phosphate metabolism_Homo sapiens_hsa005620.45396356
130p53 signaling pathway_Homo sapiens_hsa041150.44702483
131Ovarian steroidogenesis_Homo sapiens_hsa049130.43619837
132Choline metabolism in cancer_Homo sapiens_hsa052310.41071103
133Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.40599799
134Herpes simplex infection_Homo sapiens_hsa051680.40357681
135Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.40023970
136Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.39908977
137Vascular smooth muscle contraction_Homo sapiens_hsa042700.39139747
138RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.38831491
139Chemokine signaling pathway_Homo sapiens_hsa040620.38664507
140African trypanosomiasis_Homo sapiens_hsa051430.38123787
141N-Glycan biosynthesis_Homo sapiens_hsa005100.37434710
142Fructose and mannose metabolism_Homo sapiens_hsa000510.37037645
143Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.36938308
144Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.36551564
145Pentose phosphate pathway_Homo sapiens_hsa000300.35463316
146Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.33270019
147Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.32938580
148Pentose and glucuronate interconversions_Homo sapiens_hsa000400.32911603
149Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.27729902
150Steroid hormone biosynthesis_Homo sapiens_hsa001400.27400225
151Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.27140659
152Chemical carcinogenesis_Homo sapiens_hsa052040.25469089
153Tyrosine metabolism_Homo sapiens_hsa003500.22671311
154Tryptophan metabolism_Homo sapiens_hsa003800.20023180
155Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.19814872
156TGF-beta signaling pathway_Homo sapiens_hsa043500.19726540
157Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.19527678
158Drug metabolism - other enzymes_Homo sapiens_hsa009830.17835751
159Caffeine metabolism_Homo sapiens_hsa002320.15608832

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